Program: 7. Cancer Associated Fibroblast: Intermediate [Myo:Inf] (IGF1+).

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QQ-plot of gene loadings, averaged over both independent splits of the data
This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program. Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret. The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program (currently only calculated for the cells in the first 50/50 split of the data). Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

	Gene	Loading	Gene.Name	GTEx	DepMap	Descartes	Mean.Counts	Mean.Tpm
1	CCDC80	0.0069867	coiled-coil domain containing 80	GTEx	DepMap	Descartes	33.69	633.28
2	MFAP4	0.0064586	microfibril associated protein 4	GTEx	DepMap	Descartes	12.90	1457.21
3	ELN	0.0058802	elastin	GTEx	DepMap	Descartes	7.57	418.48
4	COL14A1	0.0057922	collagen type XIV alpha 1 chain	GTEx	DepMap	Descartes	17.57	538.62
5	FBLN1	0.0057041	fibulin 1	GTEx	DepMap	Descartes	15.83	1496.02
6	MEDAG	0.0054877	mesenteric estrogen dependent adipogenesis	GTEx	DepMap	Descartes	8.77	NA
7	DPT	0.0054854	dermatopontin	GTEx	DepMap	Descartes	4.56	540.73
8	SFRP2	0.0054421	secreted frizzled related protein 2	GTEx	DepMap	Descartes	15.81	1250.54
9	C7	0.0049521	complement C7	GTEx	DepMap	Descartes	33.04	1506.66
10	IER3	0.0048569	immediate early response 3	GTEx	DepMap	Descartes	40.01	6324.02
11	COL3A1	0.0047243	collagen type III alpha 1 chain	GTEx	DepMap	Descartes	126.13	4329.75
12	IL1R1	0.0045265	interleukin 1 receptor type 1	GTEx	DepMap	Descartes	6.96	344.84
13	MGP	0.0044677	matrix Gla protein	GTEx	DepMap	Descartes	85.27	13772.01
14	CXCL2	0.0044151	C-X-C motif chemokine ligand 2	GTEx	DepMap	Descartes	42.48	8440.64
15	AEBP1	0.0044091	AE binding protein 1	GTEx	DepMap	Descartes	16.00	903.07
16	SPARC	0.0043564	secreted protein acidic and cysteine rich	GTEx	DepMap	Descartes	97.15	5083.02
17	MMP2	0.0042331	matrix metallopeptidase 2	GTEx	DepMap	Descartes	9.61	638.66
18	IGF1	0.0041845	insulin like growth factor 1	GTEx	DepMap	Descartes	6.83	194.87
19	HTRA1	0.0041513	HtrA serine peptidase 1	GTEx	DepMap	Descartes	5.77	556.98
20	SERPINE1	0.0041502	serpin family E member 1	GTEx	DepMap	Descartes	39.35	2874.66
21	GPRC5A	0.0040932	G protein-coupled receptor class C group 5 member A	GTEx	DepMap	Descartes	5.66	215.98
22	ITGBL1	0.0038962	integrin subunit beta like 1	GTEx	DepMap	Descartes	2.70	116.73
23	C1QTNF3	0.0037791	C1q and TNF related 3	GTEx	DepMap	Descartes	0.92	53.26
24	GEM	0.0037334	GTP binding protein overexpressed in skeletal muscle	GTEx	DepMap	Descartes	23.11	2469.73
25	FOSL1	0.0036147	FOS like 1, AP-1 transcription factor subunit	GTEx	DepMap	Descartes	4.72	613.63
26	PTX3	0.0035189	pentraxin 3	GTEx	DepMap	Descartes	8.97	1283.17
27	GFPT2	0.0035085	glutamine-fructose-6-phosphate transaminase 2	GTEx	DepMap	Descartes	6.74	582.97
28	IGF2	0.0034368	insulin like growth factor 2	GTEx	DepMap	Descartes	16.34	672.03
29	INHBA	0.0034119	inhibin subunit beta A	GTEx	DepMap	Descartes	21.30	824.31
30	PLXDC2	0.0033209	plexin domain containing 2	GTEx	DepMap	Descartes	4.28	75.65
31	MXRA8	0.0032390	matrix remodeling associated 8	GTEx	DepMap	Descartes	5.95	482.37
32	BGN	0.0030837	biglycan	GTEx	DepMap	Descartes	26.43	2394.09
33	ANTXR1	0.0030827	ANTXR cell adhesion molecule 1	GTEx	DepMap	Descartes	4.00	134.04
34	FBLN2	0.0030609	fibulin 2	GTEx	DepMap	Descartes	4.66	258.03
35	ERRFI1	0.0030548	ERBB receptor feedback inhibitor 1	GTEx	DepMap	Descartes	8.35	627.77
36	LIF	0.0029922	LIF interleukin 6 family cytokine	GTEx	DepMap	Descartes	9.18	518.19
37	VASN	0.0029598	vasorin	GTEx	DepMap	Descartes	3.45	306.79
38	SLC39A14	0.0029184	solute carrier family 39 member 14	GTEx	DepMap	Descartes	4.06	223.46
39	PODN	0.0029106	podocan	GTEx	DepMap	Descartes	2.98	222.72
40	CDKN1A	0.0029028	cyclin dependent kinase inhibitor 1A	GTEx	DepMap	Descartes	20.30	2082.46
41	CHRDL1	0.0028977	chordin like 1	GTEx	DepMap	Descartes	1.54	105.48
42	COL1A2	0.0028888	collagen type I alpha 2 chain	GTEx	DepMap	Descartes	100.15	3194.77
43	VEGFA	0.0028868	vascular endothelial growth factor A	GTEx	DepMap	Descartes	7.40	152.45
44	CTSK	0.0028755	cathepsin K	GTEx	DepMap	Descartes	5.09	672.21
45	C3	0.0028723	complement C3	GTEx	DepMap	Descartes	13.87	728.68
46	LOX	0.0028262	lysyl oxidase	GTEx	DepMap	Descartes	2.26	99.28
47	SPSB1	0.0028231	splA/ryanodine receptor domain and SOCS box containing 1	GTEx	DepMap	Descartes	5.57	402.25
48	TNFAIP6	0.0028042	TNF alpha induced protein 6	GTEx	DepMap	Descartes	3.54	542.25
49	PRELP	0.0027685	proline and arginine rich end leucine rich repeat protein	GTEx	DepMap	Descartes	9.84	408.64
50	TUBA1C	0.0027628	tubulin alpha 1c	GTEx	DepMap	Descartes	5.08	406.42

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UMAP plots showing activity of gene expression program identified in community:7. Cancer Associated Fibroblast: Intermediate [Myo:Inf] (IGF1+)

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 7. Cancer Associated Fibroblast: Intermediate [Myo:Inf] (IGF1+):

Interactive Boxplot

CNV Data procured from inferCNV.
Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
The top cells expressing this GEP (purple)
Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes

mSigDB Cell Types Gene Set:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
CUI_DEVELOPING_HEART_SMOOTH_MUSCLE_CELL	2.31e-19	109.27	48.03	1.72e-17	1.55e-16	12CCDC80, ELN, COL14A1, FBLN1, SFRP2, COL3A1, SPARC, C1QTNF3, BGN, COL1A2, CTSK, LOX	48
GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR	2.94e-24	78.35	39.27	6.58e-22	1.97e-21	17CCDC80, COL14A1, FBLN1, DPT, SFRP2, C7, COL3A1, MGP, SPARC, MMP2, HTRA1, C1QTNF3, VASN, COL1A2, C3, LOX, TNFAIP6	99
DESCARTES_FETAL_EYE_STROMAL_CELLS	2.29e-19	63.83	30.49	1.72e-17	1.54e-16	14COL14A1, MEDAG, DPT, SFRP2, COL3A1, MGP, SPARC, ITGBL1, INHBA, VASN, PODN, COL1A2, LOX, TNFAIP6	90
TRAVAGLINI_LUNG_ADVENTITIAL_FIBROBLAST_CELL	6.57e-30	50.17	27.28	4.41e-27	4.41e-27	26CCDC80, FBLN1, MEDAG, DPT, SFRP2, C7, COL3A1, IL1R1, MGP, MMP2, IGF1, GPRC5A, C1QTNF3, FOSL1, PTX3, GFPT2, FBLN2, ERRFI1, PODN, CHRDL1, COL1A2, VEGFA, CTSK, C3, LOX, SPSB1	296
AIZARANI_LIVER_C21_STELLATE_CELLS_1	5.24e-24	47.90	25.23	8.79e-22	3.51e-21	20CCDC80, MFAP4, COL14A1, FBLN1, DPT, C7, IER3, COL3A1, MGP, AEBP1, SPARC, MMP2, SERPINE1, GEM, BGN, ANTXR1, FBLN2, CDKN1A, COL1A2, PRELP	194
DESCARTES_FETAL_THYMUS_STROMAL_CELLS	5.03e-20	48.53	24.36	5.63e-18	3.38e-17	16CCDC80, MFAP4, ELN, COL14A1, FBLN1, SFRP2, COL3A1, MGP, SPARC, MMP2, IGF2, BGN, FBLN2, COL1A2, C3, LOX	137
DESCARTES_FETAL_KIDNEY_STROMAL_CELLS	1.43e-19	45.19	22.71	1.37e-17	9.57e-17	16COL14A1, MEDAG, DPT, SFRP2, COL3A1, MGP, SPARC, IGF1, PTX3, FBLN2, PODN, CHRDL1, COL1A2, LOX, TNFAIP6, PRELP	146
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS	1.31e-14	49.59	21.99	5.50e-13	8.81e-12	11MFAP4, FBLN1, SFRP2, COL3A1, MGP, AEBP1, SPARC, ITGBL1, MXRA8, BGN, COL1A2	82
CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL	4.80e-16	42.17	19.96	2.68e-14	3.22e-13	13MFAP4, ELN, COL14A1, FBLN1, DPT, C7, MGP, SPARC, MMP2, MXRA8, FBLN2, COL1A2, LOX	117
TRAVAGLINI_LUNG_LIPOFIBROBLAST_CELL	2.47e-16	36.80	17.90	1.51e-14	1.66e-13	14CCDC80, MEDAG, C7, COL3A1, IL1R1, CXCL2, GPRC5A, FOSL1, GFPT2, ERRFI1, CDKN1A, VEGFA, C3, TUBA1C	146
DESCARTES_FETAL_STOMACH_STROMAL_CELLS	8.79e-10	47.20	16.97	2.95e-08	5.90e-07	7MFAP4, FBLN1, DPT, SFRP2, C7, COL3A1, INHBA	50
CUI_DEVELOPING_HEART_COMPACT_VENTRICULAR_CARDIOMYOCYTE	1.44e-10	41.68	16.18	5.38e-09	9.68e-08	8ELN, DPT, C7, COL3A1, MGP, SPARC, MMP2, COL1A2	65
RUBENSTEIN_SKELETAL_MUSCLE_FAP_CELLS	4.28e-15	29.44	14.39	1.91e-13	2.87e-12	14CCDC80, MFAP4, FBLN1, DPT, COL3A1, MGP, MMP2, IGF1, MXRA8, FBLN2, PODN, CHRDL1, COL1A2, C3	179
HAY_BONE_MARROW_STROMAL	5.49e-25	25.54	13.96	1.84e-22	3.69e-22	30CCDC80, COL14A1, FBLN1, MEDAG, DPT, C7, COL3A1, IL1R1, MGP, CXCL2, MMP2, HTRA1, GPRC5A, ITGBL1, GEM, PTX3, IGF2, MXRA8, BGN, ANTXR1, ERRFI1, VASN, SLC39A14, PODN, CHRDL1, COL1A2, CTSK, LOX, TNFAIP6, PRELP	765
CUI_DEVELOPING_HEART_C5_VALVAR_CELL	1.26e-15	27.75	13.84	6.02e-14	8.42e-13	15CCDC80, MFAP4, ELN, IER3, MGP, CXCL2, AEBP1, IGF1, GEM, BGN, ERRFI1, CDKN1A, CTSK, TNFAIP6, PRELP	208
RUBENSTEIN_SKELETAL_MUSCLE_FBN1_FAP_CELLS	1.23e-17	25.96	13.54	8.24e-16	8.24e-15	18CCDC80, MFAP4, ELN, COL14A1, FBLN1, MEDAG, COL3A1, MGP, MMP2, HTRA1, C1QTNF3, GFPT2, MXRA8, FBLN2, CHRDL1, COL1A2, CTSK, C3	289
MURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL	3.36e-22	22.50	12.35	4.51e-20	2.25e-19	27CCDC80, MFAP4, MEDAG, SFRP2, IER3, COL3A1, IL1R1, MGP, AEBP1, SPARC, MMP2, HTRA1, SERPINE1, GEM, GFPT2, INHBA, MXRA8, BGN, ANTXR1, LIF, VASN, COL1A2, CTSK, LOX, SPSB1, TNFAIP6, TUBA1C	680
FAN_OVARY_CL6_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_2	5.70e-16	22.74	11.74	2.94e-14	3.83e-13	17CCDC80, MFAP4, FBLN1, C7, IER3, COL3A1, MGP, AEBP1, SPARC, MMP2, IGF1, HTRA1, MXRA8, BGN, COL1A2, CTSK, PRELP	300
DESCARTES_FETAL_LUNG_MESOTHELIAL_CELLS	6.90e-09	24.52	9.69	1.93e-07	4.63e-06	8ELN, MGP, GEM, GFPT2, LIF, PODN, C3, PRELP	105
DESCARTES_FETAL_ADRENAL_STROMAL_CELLS	3.25e-10	21.83	9.55	1.15e-08	2.18e-07	10CCDC80, SFRP2, C7, COL3A1, MGP, ITGBL1, PODN, CHRDL1, LOX, PRELP	153

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mSigDB Hallmark Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	2.27e-17	31.95	16.17	1.13e-15	1.13e-15	16ELN, FBLN1, COL3A1, MGP, SPARC, MMP2, HTRA1, SERPINE1, GEM, PTX3, INHBA, BGN, FBLN2, COL1A2, VEGFA, LOX	200
HALLMARK_TNFA_SIGNALING_VIA_NFKB	5.03e-13	23.47	11.26	1.26e-11	2.51e-11	13IER3, CXCL2, SERPINE1, GEM, FOSL1, PTX3, GFPT2, INHBA, LIF, CDKN1A, VEGFA, SPSB1, TNFAIP6	200
HALLMARK_COAGULATION	1.59e-05	12.91	4.42	1.99e-04	7.96e-04	6SPARC, MMP2, HTRA1, SERPINE1, CTSK, C3	138
HALLMARK_HYPOXIA	1.19e-05	10.54	3.95	1.98e-04	5.94e-04	7IER3, SERPINE1, BGN, ERRFI1, CDKN1A, VEGFA, LOX	200
HALLMARK_INFLAMMATORY_RESPONSE	1.24e-04	8.78	3.02	1.24e-03	6.18e-03	6IL1R1, SERPINE1, INHBA, LIF, CDKN1A, TNFAIP6	200
HALLMARK_MYOGENESIS	1.08e-03	7.12	2.18	7.71e-03	5.40e-02	5COL3A1, AEBP1, SPARC, IGF1, CDKN1A	200
HALLMARK_KRAS_SIGNALING_UP	1.08e-03	7.12	2.18	7.71e-03	5.40e-02	5ITGBL1, GFPT2, IGF2, INHBA, LIF	200
HALLMARK_APOPTOSIS	3.63e-03	6.92	1.79	2.27e-02	1.82e-01	4IER3, MMP2, BGN, CDKN1A	161
HALLMARK_ANGIOGENESIS	8.94e-03	15.30	1.73	4.47e-02	4.47e-01	2COL3A1, VEGFA	36
HALLMARK_XENOBIOTIC_METABOLISM	7.71e-03	5.55	1.44	4.28e-02	3.85e-01	4FBLN1, IL1R1, IGF1, SERPINE1	200
HALLMARK_UV_RESPONSE_DN	1.90e-02	5.66	1.11	8.64e-02	9.50e-01	3COL3A1, SERPINE1, COL1A2	144
HALLMARK_P53_PATHWAY	4.35e-02	4.05	0.80	1.81e-01	1.00e+00	3IER3, LIF, CDKN1A	200
HALLMARK_INTERFERON_GAMMA_RESPONSE	1.85e-01	2.63	0.31	5.38e-01	1.00e+00	2CDKN1A, TNFAIP6	200
HALLMARK_COMPLEMENT	1.85e-01	2.63	0.31	5.38e-01	1.00e+00	2SERPINE1, C3	200
HALLMARK_GLYCOLYSIS	1.85e-01	2.63	0.31	5.38e-01	1.00e+00	2IER3, VEGFA	200
HALLMARK_ALLOGRAFT_REJECTION	1.85e-01	2.63	0.31	5.38e-01	1.00e+00	2INHBA, LIF	200
HALLMARK_HEDGEHOG_SIGNALING	1.34e-01	7.29	0.18	5.14e-01	1.00e+00	1VEGFA	36
HALLMARK_TGF_BETA_SIGNALING	1.94e-01	4.81	0.12	5.38e-01	1.00e+00	1SERPINE1	54
HALLMARK_CHOLESTEROL_HOMEOSTASIS	2.55e-01	3.49	0.09	6.71e-01	1.00e+00	1ERRFI1	74
HALLMARK_IL6_JAK_STAT3_SIGNALING	2.93e-01	2.97	0.07	7.31e-01	1.00e+00	1IL1R1	87

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KEGG Pathways:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
KEGG_BLADDER_CANCER	6.07e-04	20.43	3.90	1.13e-01	1.13e-01	3MMP2, CDKN1A, VEGFA	42
KEGG_P53_SIGNALING_PATHWAY	2.45e-03	12.27	2.38	1.58e-01	4.55e-01	3IGF1, SERPINE1, CDKN1A	68
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	2.55e-03	12.08	2.35	1.58e-01	4.75e-01	3C7, SERPINE1, C3	69
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	3.61e-03	5.34	1.64	1.68e-01	6.72e-01	5IL1R1, CXCL2, INHBA, LIF, VEGFA	265
KEGG_FOCAL_ADHESION	7.58e-03	5.57	1.44	2.82e-01	1.00e+00	4COL3A1, IGF1, COL1A2, VEGFA	199
KEGG_MTOR_SIGNALING_PATHWAY	1.80e-02	10.41	1.19	5.59e-01	1.00e+00	2IGF1, VEGFA	52
KEGG_GLIOMA	2.73e-02	8.26	0.95	7.26e-01	1.00e+00	2IGF1, CDKN1A	65
KEGG_PATHWAYS_IN_CANCER	3.70e-02	3.39	0.88	7.65e-01	1.00e+00	4MMP2, IGF1, CDKN1A, VEGFA	325
KEGG_MELANOMA	3.21e-02	7.55	0.87	7.47e-01	1.00e+00	2IGF1, CDKN1A	71
KEGG_ECM_RECEPTOR_INTERACTION	4.36e-02	6.35	0.74	8.10e-01	1.00e+00	2COL3A1, COL1A2	84
KEGG_PROSTATE_CANCER	4.83e-02	5.98	0.69	8.17e-01	1.00e+00	2IGF1, CDKN1A	89
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS	1.04e-01	3.80	0.44	1.00e+00	1.00e+00	2C7, C3	139
KEGG_WNT_SIGNALING_PATHWAY	1.19e-01	3.50	0.41	1.00e+00	1.00e+00	2SFRP2, FOSL1	151
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM	1.20e-01	8.23	0.20	1.00e+00	1.00e+00	1GFPT2	32
KEGG_PRION_DISEASES	1.30e-01	7.50	0.18	1.00e+00	1.00e+00	1C7	35
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	1.54e-01	6.22	0.15	1.00e+00	1.00e+00	1IGF1	42
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM	1.61e-01	5.93	0.14	1.00e+00	1.00e+00	1GFPT2	44
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	2.00e-01	4.64	0.11	1.00e+00	1.00e+00	1TUBA1C	56
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	2.19e-01	4.18	0.10	1.00e+00	1.00e+00	1CXCL2	62
KEGG_LONG_TERM_DEPRESSION	2.43e-01	3.70	0.09	1.00e+00	1.00e+00	1IGF1	70

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CHR Positional Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
chr5p13	9.06e-02	4.13	0.48	1.00e+00	1.00e+00	2C7, C1QTNF3	128
chr6p21	4.27e-01	1.72	0.34	1.00e+00	1.00e+00	3IER3, CDKN1A, VEGFA	467
chr1p36	7.38e-01	1.22	0.24	1.00e+00	1.00e+00	3MXRA8, ERRFI1, SPSB1	656
chr7p13	1.81e-01	5.21	0.13	1.00e+00	1.00e+00	1AEBP1	50
chr2q23	1.84e-01	5.10	0.12	1.00e+00	1.00e+00	1TNFAIP6	51
chr13q33	1.97e-01	4.72	0.12	1.00e+00	1.00e+00	1ITGBL1	55
chrXq23	2.98e-01	2.90	0.07	1.00e+00	1.00e+00	1CHRDL1	89
chr16q12	3.17e-01	2.68	0.07	1.00e+00	1.00e+00	1MMP2	96
chr12p12	3.46e-01	2.41	0.06	1.00e+00	1.00e+00	1MGP	107
chr2q32	3.49e-01	2.38	0.06	1.00e+00	1.00e+00	1COL3A1	108
chr5q33	3.52e-01	2.36	0.06	1.00e+00	1.00e+00	1SPARC	109
chr5q23	3.57e-01	2.32	0.06	1.00e+00	1.00e+00	1LOX	111
chr1q24	3.87e-01	2.09	0.05	1.00e+00	1.00e+00	1DPT	123
chr8p21	3.99e-01	2.01	0.05	1.00e+00	1.00e+00	1SLC39A14	128
chr10p12	4.15e-01	1.90	0.05	1.00e+00	1.00e+00	1PLXDC2	135
chr2p13	4.20e-01	1.88	0.05	1.00e+00	1.00e+00	1ANTXR1	137
chr12q23	4.38e-01	1.77	0.04	1.00e+00	1.00e+00	1IGF1	145
chr3p25	4.38e-01	1.77	0.04	1.00e+00	1.00e+00	1FBLN2	145
chr2q11	4.40e-01	1.76	0.04	1.00e+00	1.00e+00	1IL1R1	146
chr1p32	4.53e-01	1.69	0.04	1.00e+00	1.00e+00	1PODN	152

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Transcription Factor Targets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
FREAC4_01	3.25e-04	9.38	2.87	1.84e-01	3.68e-01	5IGF1, INHBA, VASN, CDKN1A, LOX	153
SRF_Q6	2.73e-03	5.72	1.76	3.54e-01	1.00e+00	5IGF1, FOSL1, PODN, COL1A2, PRELP	248
TGGAAA_NFAT_Q4_01	1.59e-04	3.36	1.75	1.80e-01	1.80e-01	17CCDC80, IER3, MGP, IGF1, C1QTNF3, INHBA, MXRA8, ANTXR1, ERRFI1, LIF, PODN, CDKN1A, COL1A2, VEGFA, CTSK, LOX, PRELP	1934
AACTTT_UNKNOWN	5.19e-04	3.08	1.58	1.96e-01	5.88e-01	16CCDC80, COL3A1, SPARC, MMP2, IGF1, ITGBL1, GEM, FOSL1, GFPT2, INHBA, PLXDC2, CHRDL1, COL1A2, VEGFA, LOX, TUBA1C	1928
CCCNNNNNNAAGWT_UNKNOWN	7.99e-03	7.90	1.55	4.32e-01	1.00e+00	3IER3, IGF1, INHBA	104
GTGGGTGK_UNKNOWN	5.78e-03	4.76	1.46	4.32e-01	1.00e+00	5SPARC, IGF1, SERPINE1, CHRDL1, VEGFA	297
FREAC7_01	7.71e-03	5.55	1.44	4.32e-01	1.00e+00	4IER3, CXCL2, MXRA8, ERRFI1	200
PSMB5_TARGET_GENES	6.61e-03	4.60	1.41	4.32e-01	1.00e+00	5IER3, SERPINE1, VASN, VEGFA, TUBA1C	307
HFH8_01	8.81e-03	5.33	1.38	4.32e-01	1.00e+00	4CXCL2, C1QTNF3, INHBA, MXRA8	208
HNF3ALPHA_Q6	9.24e-03	5.25	1.36	4.32e-01	1.00e+00	4ERRFI1, VASN, CDKN1A, CHRDL1	211
RP58_01	9.39e-03	5.22	1.35	4.32e-01	1.00e+00	4COL3A1, IGF1, GFPT2, PODN	212
FOX_Q2	9.54e-03	5.20	1.35	4.32e-01	1.00e+00	4ITGBL1, ERRFI1, VASN, CDKN1A	213
GGGTGGRR_PAX4_03	6.10e-03	2.72	1.25	4.32e-01	1.00e+00	11ELN, SPARC, IGF1, SERPINE1, IGF2, LIF, SLC39A14, PODN, CDKN1A, CHRDL1, PRELP	1310
VDR_Q3	1.27e-02	4.77	1.24	4.49e-01	1.00e+00	4PLXDC2, ERRFI1, LIF, VEGFA	232
FOXO1_01	1.58e-02	4.45	1.16	5.19e-01	1.00e+00	4C1QTNF3, INHBA, PLXDC2, MXRA8	248
HFH1_01	1.64e-02	4.40	1.14	5.19e-01	1.00e+00	4C1QTNF3, INHBA, MXRA8, ERRFI1	251
ATF3_Q6	1.69e-02	4.37	1.13	5.19e-01	1.00e+00	4IGF1, GEM, MXRA8, CDKN1A	253
AP4_01	1.96e-02	4.16	1.08	5.19e-01	1.00e+00	4IGF1, SERPINE1, VEGFA, TUBA1C	265
POU3F2_02	1.96e-02	4.16	1.08	5.19e-01	1.00e+00	4CCDC80, SFRP2, ERRFI1, LOX	265
WGTTNNNNNAAA_UNKNOWN	1.82e-02	3.11	1.08	5.19e-01	1.00e+00	6IER3, MGP, MMP2, PLXDC2, CDKN1A, VEGFA	554

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GO Biological Processes:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GOBP_COLLAGEN_FIBRIL_ORGANIZATION	1.54e-09	43.22	15.60	5.75e-06	1.15e-05	7COL14A1, DPT, SFRP2, COL3A1, AEBP1, COL1A2, LOX	54
GOBP_LUNG_VASCULATURE_DEVELOPMENT	1.54e-04	172.68	14.09	6.58e-02	1.00e+00	2ERRFI1, LIF	5
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION	6.51e-18	22.18	11.82	4.87e-14	4.87e-14	20CCDC80, MFAP4, ELN, COL14A1, FBLN1, DPT, SFRP2, COL3A1, AEBP1, SPARC, MMP2, HTRA1, SERPINE1, PTX3, BGN, ANTXR1, FBLN2, COL1A2, CTSK, LOX	396
GOBP_DENTINOGENESIS	2.31e-04	129.66	11.45	8.22e-02	1.00e+00	2HTRA1, SERPINE1	6
GOBP_CELLULAR_RESPONSE_TO_UV_B	4.28e-04	86.37	8.33	1.23e-01	1.00e+00	2MFAP4, CDKN1A	8
GOBP_EXTRACELLULAR_MATRIX_ASSEMBLY	2.91e-05	26.48	6.62	2.17e-02	2.17e-01	4MFAP4, ANTXR1, COL1A2, LOX	45
GOBP_RESPONSE_TO_GRAVITY	6.85e-04	64.86	6.55	1.66e-01	1.00e+00	2SPARC, FOSL1	10
GOBP_ELASTIC_FIBER_ASSEMBLY	6.85e-04	64.86	6.55	1.66e-01	1.00e+00	2MFAP4, LOX	10
GOBP_SKIN_MORPHOGENESIS	8.35e-04	57.69	5.91	1.86e-01	1.00e+00	2ERRFI1, COL1A2	11
GOBP_NEGATIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY	1.37e-03	43.30	4.59	2.06e-01	1.00e+00	2GPRC5A, ERRFI1	14
GOBP_CELL_ADHESION_MEDIATED_BY_INTEGRIN	1.84e-04	15.97	4.06	6.88e-02	1.00e+00	4SFRP2, SERPINE1, ITGBL1, LIF	72
GOBP_COLLAGEN_METABOLIC_PROCESS	6.72e-05	13.34	4.05	3.59e-02	5.03e-01	5MFAP4, MMP2, ERRFI1, COL1A2, CTSK	109
GOBP_RESPONSE_TO_UV_B	1.80e-03	37.11	3.99	2.32e-01	1.00e+00	2MFAP4, CDKN1A	16
GOBP_OVULATION	1.80e-03	37.11	3.99	2.32e-01	1.00e+00	2INHBA, TNFAIP6	16
GOBP_REPLICATIVE_SENESCENCE	2.03e-03	34.68	3.75	2.45e-01	1.00e+00	2SERPINE1, CDKN1A	17
GOBP_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY	2.28e-03	32.49	3.53	2.66e-01	1.00e+00	2C7, C3	18
GOBP_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS	2.28e-03	32.49	3.53	2.66e-01	1.00e+00	2IGF1, IGF2	18
GOBP_MACROPHAGE_DIFFERENTIATION	8.44e-04	18.11	3.48	1.86e-01	1.00e+00	3INHBA, LIF, VEGFA	47
GOBP_PLATELET_DEGRANULATION	1.43e-04	11.29	3.44	6.58e-02	1.00e+00	5SPARC, IGF1, SERPINE1, IGF2, VEGFA	128
GOBP_SKELETAL_SYSTEM_DEVELOPMENT	1.70e-06	7.44	3.42	2.54e-03	1.27e-02	11SFRP2, COL3A1, MGP, MMP2, IGF1, IGF2, BGN, SLC39A14, COL1A2, LOX, PRELP	485

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Immunological Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GSE9988_LOW_LPS_VS_VEHICLE_TREATED_MONOCYTE_UP	5.82e-08	14.67	6.18	2.84e-04	2.84e-04	9IER3, CXCL2, GPRC5A, GEM, FOSL1, PTX3, INHBA, ERRFI1, TNFAIP6	196
GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_UP	7.76e-07	12.80	5.12	1.89e-03	3.78e-03	8IER3, CXCL2, GPRC5A, GEM, FOSL1, INHBA, ERRFI1, CDKN1A	194
GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_UP	9.76e-06	10.88	4.08	3.62e-03	4.76e-02	7IL1R1, CXCL2, GPRC5A, GEM, FOSL1, INHBA, CDKN1A	194
GSE9988_LPS_VS_CTRL_TREATED_MONOCYTE_UP	1.04e-05	10.76	4.03	3.62e-03	5.08e-02	7IER3, CXCL2, FOSL1, PTX3, INHBA, CDKN1A, TNFAIP6	196
GSE9988_LPS_VS_VEHICLE_TREATED_MONOCYTE_UP	1.04e-05	10.76	4.03	3.62e-03	5.08e-02	7IER3, CXCL2, GEM, FOSL1, PTX3, INHBA, TNFAIP6	196
GSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_UP	1.04e-05	10.76	4.03	3.62e-03	5.08e-02	7IER3, CXCL2, FOSL1, PTX3, INHBA, ERRFI1, TNFAIP6	196
GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_UP	1.11e-05	10.65	3.99	3.62e-03	5.42e-02	7IL1R1, CXCL2, GPRC5A, GEM, FOSL1, INHBA, CDKN1A	198
GSE45365_NK_CELL_VS_CD11B_DC_DN	1.15e-05	10.60	3.97	3.62e-03	5.60e-02	7IER3, CXCL2, SERPINE1, GPRC5A, FOSL1, PTX3, LIF	199
GSE8835_HEALTHY_VS_CLL_CD8_TCELL_DN	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7COL3A1, MMP2, SERPINE1, ANTXR1, ERRFI1, COL1A2, VEGFA	200
GSE9316_IL6_KO_VS_IFNG_KO_INVIVO_EXPANDED_CD4_TCELL_DN	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7IER3, CXCL2, SERPINE1, LIF, CDKN1A, LOX, SPSB1	200
GSE19198_CTRL_VS_IL21_TREATED_TCELL_24H_UP	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7CXCL2, SERPINE1, ERRFI1, SLC39A14, CDKN1A, LOX, SPSB1	200
GSE22140_HEALTHY_VS_ARTHRITIC_GERMFREE_MOUSE_CD4_TCELL_DN	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7IER3, IGF1, SERPINE1, GEM, PTX3, CDKN1A, CTSK	200
GSE28737_BCL6_HET_VS_BCL6_KO_FOLLICULAR_BCELL_DN	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7SPARC, GFPT2, BGN, FBLN2, COL1A2, CTSK, LOX	200
GSE42021_TREG_PLN_VS_CD24HI_TREG_THYMUS_UP	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7IER3, CXCL2, SERPINE1, IGF2, FBLN2, ERRFI1, CDKN1A	200
GSE42021_CD24HI_TREG_VS_CD24HI_TCONV_THYMUS_DN	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7IER3, CXCL2, SERPINE1, BGN, FBLN2, ERRFI1, CDKN1A	200
GSE27434_WT_VS_DNMT1_KO_TREG_DN	1.19e-05	10.54	3.95	3.62e-03	5.79e-02	7CXCL2, SERPINE1, INHBA, FBLN2, ERRFI1, CDKN1A, COL1A2	200
GSE9988_ANTI_TREM1_AND_LPS_VS_VEHICLE_TREATED_MONOCYTES_UP	1.08e-04	9.02	3.10	2.74e-02	5.25e-01	6IER3, CXCL2, GPRC5A, GEM, FOSL1, INHBA	195
GSE8515_CTRL_VS_IL1_4H_STIM_MAC_DN	1.14e-04	8.92	3.07	2.74e-02	5.55e-01	6IER3, MGP, CXCL2, PTX3, LIF, TNFAIP6	197
GSE20715_0H_VS_24H_OZONE_TLR4_KO_LUNG_DN	1.24e-04	8.78	3.02	2.74e-02	6.03e-01	6ELN, CXCL2, SLC39A14, CDKN1A, LOX, SPSB1	200
GSE22886_DAY0_VS_DAY1_MONOCYTE_IN_CULTURE_DN	1.24e-04	8.78	3.02	2.74e-02	6.03e-01	6IER3, CXCL2, INHBA, CDKN1A, C3, TNFAIP6	200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol	TF Rank	DNA Binding Domain	Motif Status	IUPAC PWM	GTEx	DepMap	Decartes
AEBP1	15	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).
FOSL1	25	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
CDKN1A	40	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
VEGFA	43	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Extracellular signaling molecule. Included only because it regulates CREB.
GREM1	59	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
FBN1	61	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
NFIX	67	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
THAP2	69	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	None
VDR	84	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
RYBP	86	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains RanBP ZFs, so likely an RNA-binding protein
PRRX1	89	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
CEBPB	92	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
CREB3L1	98	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
GLIS2	99	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
GLIS3	106	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
FHL2	118	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	LIM ZF proteins are unlikely to bind DNA. Experimental evidence does not support a role for FHL2 as a sequence-specific DNA-binding protein (PMID:10654935)
RUNX1	121	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None
XBP1	128	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
FOXC1	129	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
NFKBIA	130	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	This is I kappa B alpha, which interacts with NFkappaB. No DBD, and evidence indicates that it is not a TF.

QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID	Singler label	Singler Delta	Activity Score	Top Singler Raw Scores
WK032-N7	Fibroblasts:breast	0.29	1196.58	Raw ScoresFibroblasts:breast: 0.61, iPS_cells:adipose_stem_cells: 0.6, Smooth_muscle_cells:vascular:IL-17: 0.58, Smooth_muscle_cells:vascular: 0.58, Osteoblasts: 0.58, iPS_cells:CRL2097_foreskin: 0.58, Osteoblasts:BMP2: 0.57, Smooth_muscle_cells:bronchial: 0.57, Chondrocytes:MSC-derived: 0.57, Smooth_muscle_cells:bronchial:vit_D: 0.56
WK012-H21	Fibroblasts:breast	0.28	1167.94	Raw ScoresFibroblasts:breast: 0.58, iPS_cells:adipose_stem_cells: 0.57, Chondrocytes:MSC-derived: 0.56, Smooth_muscle_cells:vascular:IL-17: 0.56, Smooth_muscle_cells:vascular: 0.56, Smooth_muscle_cells:bronchial: 0.56, Tissue_stem_cells:BM_MSC:TGFb3: 0.55, iPS_cells:CRL2097_foreskin: 0.55, Osteoblasts: 0.55, Smooth_muscle_cells:bronchial:vit_D: 0.55
WK014-N15	Fibroblasts:breast	0.28	1138.27	Raw ScoresFibroblasts:breast: 0.58, iPS_cells:adipose_stem_cells: 0.58, Smooth_muscle_cells:vascular:IL-17: 0.57, Smooth_muscle_cells:vascular: 0.56, iPS_cells:CRL2097_foreskin: 0.56, Osteoblasts: 0.56, Chondrocytes:MSC-derived: 0.56, Tissue_stem_cells:BM_MSC:TGFb3: 0.56, Smooth_muscle_cells:bronchial: 0.56, Osteoblasts:BMP2: 0.55
WK014-I5	iPS_cells:adipose_stem_cells	0.28	964.77	Raw ScoresFibroblasts:breast: 0.58, iPS_cells:adipose_stem_cells: 0.58, Chondrocytes:MSC-derived: 0.56, Osteoblasts: 0.56, Smooth_muscle_cells:vascular: 0.56, iPS_cells:CRL2097_foreskin: 0.56, Smooth_muscle_cells:vascular:IL-17: 0.56, Osteoblasts:BMP2: 0.55, Tissue_stem_cells:BM_MSC:TGFb3: 0.55, Smooth_muscle_cells:bronchial: 0.55
WK012-E21	Fibroblasts:breast	0.25	932.67	Raw ScoresFibroblasts:breast: 0.5, iPS_cells:adipose_stem_cells: 0.48, Smooth_muscle_cells:vascular:IL-17: 0.48, Osteoblasts: 0.48, Smooth_muscle_cells:vascular: 0.48, Chondrocytes:MSC-derived: 0.48, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Smooth_muscle_cells:bronchial: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Smooth_muscle_cells:bronchial:vit_D: 0.47
WK012-N11	Tissue_stem_cells:BM_MSC:TGFb3	0.21	931.33	Raw ScoresFibroblasts:breast: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.48, iPS_cells:adipose_stem_cells: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.47, Osteoblasts: 0.47, Smooth_muscle_cells:bronchial: 0.47, Smooth_muscle_cells:vascular: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.47, Smooth_muscle_cells:bronchial:vit_D: 0.47, Tissue_stem_cells:iliac_MSC: 0.46
WK014-I7	Fibroblasts:breast	0.25	920.90	Raw ScoresFibroblasts:breast: 0.49, iPS_cells:adipose_stem_cells: 0.48, Smooth_muscle_cells:vascular:IL-17: 0.47, Smooth_muscle_cells:vascular: 0.47, Chondrocytes:MSC-derived: 0.46, Osteoblasts: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.46, iPS_cells:CRL2097_foreskin: 0.46, Smooth_muscle_cells:bronchial: 0.46, Smooth_muscle_cells:bronchial:vit_D: 0.45
WK012-M5	Fibroblasts:breast	0.24	871.23	Raw ScoresFibroblasts:breast: 0.5, iPS_cells:adipose_stem_cells: 0.48, Smooth_muscle_cells:vascular: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Chondrocytes:MSC-derived: 0.47, Osteoblasts: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Smooth_muscle_cells:bronchial: 0.47, Smooth_muscle_cells:bronchial:vit_D: 0.46
WK014-O16	Fibroblasts:breast	0.23	840.00	Raw ScoresFibroblasts:breast: 0.47, iPS_cells:adipose_stem_cells: 0.46, Smooth_muscle_cells:vascular:IL-17: 0.45, Chondrocytes:MSC-derived: 0.45, Tissue_stem_cells:BM_MSC:TGFb3: 0.45, Smooth_muscle_cells:vascular: 0.45, Osteoblasts: 0.45, Smooth_muscle_cells:bronchial: 0.45, iPS_cells:CRL2097_foreskin: 0.44, Smooth_muscle_cells:bronchial:vit_D: 0.44
WK012-E6	Fibroblasts:breast	0.26	838.99	Raw ScoresFibroblasts:breast: 0.52, iPS_cells:adipose_stem_cells: 0.51, Smooth_muscle_cells:vascular:IL-17: 0.5, Smooth_muscle_cells:vascular: 0.5, iPS_cells:CRL2097_foreskin: 0.49, Osteoblasts:BMP2: 0.49, Osteoblasts: 0.49, Chondrocytes:MSC-derived: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.48, Tissue_stem_cells:BM_MSC: 0.48
TM37-O7	Chondrocytes:MSC-derived	0.23	754.62	Raw ScoresFibroblasts:breast: 0.52, Chondrocytes:MSC-derived: 0.52, Osteoblasts: 0.51, iPS_cells:adipose_stem_cells: 0.51, Tissue_stem_cells:BM_MSC:TGFb3: 0.51, Tissue_stem_cells:BM_MSC:BMP2: 0.51, Smooth_muscle_cells:vascular:IL-17: 0.51, Smooth_muscle_cells:vascular: 0.5, iPS_cells:CRL2097_foreskin: 0.5, Osteoblasts:BMP2: 0.5
WK012-N7	Tissue_stem_cells:BM_MSC:TGFb3	0.23	744.98	Raw ScoresFibroblasts:breast: 0.48, iPS_cells:adipose_stem_cells: 0.48, Smooth_muscle_cells:bronchial: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Smooth_muscle_cells:bronchial:vit_D: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.46, iPS_cells:CRL2097_foreskin: 0.46, Chondrocytes:MSC-derived: 0.46, Osteoblasts: 0.46, Smooth_muscle_cells:vascular: 0.46
WK012-K22	Smooth_muscle_cells:vascular:IL-17	0.21	672.70	Raw ScoresFibroblasts:breast: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.48, iPS_cells:adipose_stem_cells: 0.48, Smooth_muscle_cells:vascular: 0.48, Osteoblasts: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Chondrocytes:MSC-derived: 0.47, Smooth_muscle_cells:bronchial: 0.47, Osteoblasts:BMP2: 0.46, Smooth_muscle_cells:bronchial:vit_D: 0.46
WK012-M17	Fibroblasts:breast	0.24	671.07	Raw ScoresFibroblasts:breast: 0.52, iPS_cells:adipose_stem_cells: 0.52, Chondrocytes:MSC-derived: 0.51, Osteoblasts: 0.51, Smooth_muscle_cells:vascular:IL-17: 0.51, Smooth_muscle_cells:vascular: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, iPS_cells:CRL2097_foreskin: 0.5, Osteoblasts:BMP2: 0.5, Tissue_stem_cells:BM_MSC:BMP2: 0.5
WK032-L21	Fibroblasts:breast	0.28	670.30	Raw ScoresFibroblasts:breast: 0.54, iPS_cells:adipose_stem_cells: 0.54, Osteoblasts: 0.53, Chondrocytes:MSC-derived: 0.52, Smooth_muscle_cells:vascular: 0.52, Smooth_muscle_cells:vascular:IL-17: 0.52, iPS_cells:CRL2097_foreskin: 0.52, Osteoblasts:BMP2: 0.52, Smooth_muscle_cells:bronchial: 0.52, Tissue_stem_cells:BM_MSC:TGFb3: 0.51
WK012-J11	iPS_cells:adipose_stem_cells	0.23	636.57	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.51, Osteoblasts: 0.5, Smooth_muscle_cells:vascular: 0.5, Chondrocytes:MSC-derived: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, iPS_cells:CRL2097_foreskin: 0.5, Tissue_stem_cells:BM_MSC:BMP2: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Osteoblasts:BMP2: 0.49
WK012-O16	iPS_cells:adipose_stem_cells	0.23	631.12	Raw ScoresFibroblasts:breast: 0.48, iPS_cells:adipose_stem_cells: 0.47, Osteoblasts: 0.47, Chondrocytes:MSC-derived: 0.46, Smooth_muscle_cells:vascular:IL-17: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.46, Smooth_muscle_cells:vascular: 0.46, Osteoblasts:BMP2: 0.46, Tissue_stem_cells:BM_MSC:BMP2: 0.46, iPS_cells:CRL2097_foreskin: 0.45
WK014-L9	Tissue_stem_cells:BM_MSC:TGFb3	0.21	623.11	Raw ScoresFibroblasts:breast: 0.43, Tissue_stem_cells:BM_MSC:TGFb3: 0.42, Smooth_muscle_cells:vascular:IL-17: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.41, Osteoblasts: 0.41, Smooth_muscle_cells:vascular: 0.41, Tissue_stem_cells:BM_MSC:BMP2: 0.41, Smooth_muscle_cells:bronchial: 0.4, Osteoblasts:BMP2: 0.4
WK014-O23	Fibroblasts:breast	0.25	616.01	Raw ScoresFibroblasts:breast: 0.53, iPS_cells:adipose_stem_cells: 0.52, Osteoblasts: 0.5, Smooth_muscle_cells:vascular: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, Osteoblasts:BMP2: 0.5, Smooth_muscle_cells:bronchial: 0.49
WK014-P12	Smooth_muscle_cells:vascular:IL-17	0.22	610.92	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.48, Fibroblasts:breast: 0.47, Smooth_muscle_cells:vascular: 0.47, iPS_cells:adipose_stem_cells: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.46, Tissue_stem_cells:BM_MSC:BMP2: 0.46, Smooth_muscle_cells:bronchial: 0.45, Smooth_muscle_cells:bronchial:vit_D: 0.45, Osteoblasts: 0.45, Osteoblasts:BMP2: 0.45
WK014-N5	Fibroblasts:breast	0.24	591.02	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.51, Smooth_muscle_cells:vascular:IL-17: 0.5, Osteoblasts: 0.5, Smooth_muscle_cells:vascular: 0.5, Chondrocytes:MSC-derived: 0.5, Tissue_stem_cells:BM_MSC:BMP2: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Osteoblasts:BMP2: 0.49, Smooth_muscle_cells:bronchial: 0.49
WK012-K3	iPS_cells:adipose_stem_cells	0.22	590.77	Raw ScoresFibroblasts:breast: 0.52, iPS_cells:adipose_stem_cells: 0.51, Smooth_muscle_cells:vascular:IL-17: 0.5, Smooth_muscle_cells:vascular: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, Tissue_stem_cells:BM_MSC:BMP2: 0.5, Tissue_stem_cells:BM_MSC: 0.49, Chondrocytes:MSC-derived: 0.49, Osteoblasts: 0.49, Osteoblasts:BMP2: 0.49
WK014-P19	Fibroblasts:breast	0.24	590.15	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.51, Chondrocytes:MSC-derived: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.49, Smooth_muscle_cells:vascular: 0.49, Smooth_muscle_cells:bronchial: 0.49, Osteoblasts: 0.49, Osteoblasts:BMP2: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Smooth_muscle_cells:bronchial:vit_D: 0.49
WK014-H2	Smooth_muscle_cells:vascular:IL-17	0.22	584.87	Raw ScoresFibroblasts:breast: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.47, iPS_cells:adipose_stem_cells: 0.46, Smooth_muscle_cells:vascular: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.46, Chondrocytes:MSC-derived: 0.45, iPS_cells:CRL2097_foreskin: 0.45, Osteoblasts: 0.45, Smooth_muscle_cells:bronchial: 0.45, Osteoblasts:BMP2: 0.45
WK014-I9	Fibroblasts:breast	0.24	558.82	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.51, Smooth_muscle_cells:vascular: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Osteoblasts: 0.49, Chondrocytes:MSC-derived: 0.49, Osteoblasts:BMP2: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.49, iPS_cells:CRL2097_foreskin: 0.48
WK014-H16	Fibroblasts:breast	0.24	549.00	Raw ScoresFibroblasts:breast: 0.49, iPS_cells:adipose_stem_cells: 0.48, Smooth_muscle_cells:vascular:IL-17: 0.48, Chondrocytes:MSC-derived: 0.47, Osteoblasts: 0.47, Smooth_muscle_cells:vascular: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Smooth_muscle_cells:bronchial: 0.46, iPS_cells:CRL2097_foreskin: 0.46, Osteoblasts:BMP2: 0.46
WK014-G5	Chondrocytes:MSC-derived	0.25	534.76	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.5, Chondrocytes:MSC-derived: 0.49, Osteoblasts: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49, Smooth_muscle_cells:vascular: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.48, iPS_cells:CRL2097_foreskin: 0.48, Tissue_stem_cells:BM_MSC: 0.48, Tissue_stem_cells:BM_MSC:BMP2: 0.48
WK012-J17	iPS_cells:adipose_stem_cells	0.24	528.86	Raw ScoresFibroblasts:breast: 0.52, iPS_cells:adipose_stem_cells: 0.51, Chondrocytes:MSC-derived: 0.5, Osteoblasts: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, iPS_cells:CRL2097_foreskin: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49, Smooth_muscle_cells:bronchial: 0.49, Smooth_muscle_cells:vascular: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.49
WK014-M1	Chondrocytes:MSC-derived	0.22	527.37	Raw ScoresFibroblasts:breast: 0.49, Chondrocytes:MSC-derived: 0.49, iPS_cells:adipose_stem_cells: 0.49, Osteoblasts: 0.48, Tissue_stem_cells:BM_MSC:TGFb3: 0.48, Smooth_muscle_cells:bronchial: 0.48, Smooth_muscle_cells:bronchial:vit_D: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Osteoblasts:BMP2: 0.47
WK012-E18	Chondrocytes:MSC-derived	0.23	527.37	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.5, Chondrocytes:MSC-derived: 0.49, Osteoblasts: 0.49, iPS_cells:CRL2097_foreskin: 0.48, Smooth_muscle_cells:vascular:IL-17: 0.48, Tissue_stem_cells:BM_MSC:TGFb3: 0.48, Smooth_muscle_cells:vascular: 0.48, Osteoblasts:BMP2: 0.48, Smooth_muscle_cells:bronchial: 0.48
WK066-H2	Smooth_muscle_cells:vascular:IL-17	0.20	518.93	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, Smooth_muscle_cells:vascular: 0.5, Tissue_stem_cells:BM_MSC:BMP2: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Osteoblasts:BMP2: 0.49, Osteoblasts: 0.49, iPS_cells:CRL2097_foreskin: 0.49, Smooth_muscle_cells:bronchial: 0.49
TM37-F20	Smooth_muscle_cells:vascular:IL-17	0.18	514.88	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.45, Fibroblasts:breast: 0.45, Tissue_stem_cells:BM_MSC:TGFb3: 0.45, Smooth_muscle_cells:vascular: 0.44, iPS_cells:adipose_stem_cells: 0.44, Tissue_stem_cells:BM_MSC:BMP2: 0.44, Chondrocytes:MSC-derived: 0.43, Osteoblasts: 0.43, Osteoblasts:BMP2: 0.43, Smooth_muscle_cells:bronchial: 0.43
WK014-F19	Fibroblasts:breast	0.24	480.26	Raw ScoresFibroblasts:breast: 0.52, iPS_cells:adipose_stem_cells: 0.52, Osteoblasts: 0.51, Chondrocytes:MSC-derived: 0.51, Smooth_muscle_cells:vascular: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, Smooth_muscle_cells:bronchial: 0.5, iPS_cells:CRL2097_foreskin: 0.5, Smooth_muscle_cells:bronchial:vit_D: 0.49
WK032-C7	Fibroblasts:breast	0.23	476.65	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, Smooth_muscle_cells:vascular: 0.49, Chondrocytes:MSC-derived: 0.49, Osteoblasts: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.48, iPS_cells:CRL2097_foreskin: 0.48, Smooth_muscle_cells:bronchial: 0.48
TM96-C21	Chondrocytes:MSC-derived	0.23	476.34	Raw ScoresChondrocytes:MSC-derived: 0.57, Osteoblasts: 0.55, iPS_cells:adipose_stem_cells: 0.55, Tissue_stem_cells:BM_MSC:TGFb3: 0.55, Fibroblasts:breast: 0.54, Osteoblasts:BMP2: 0.54, Tissue_stem_cells:BM_MSC:BMP2: 0.54, iPS_cells:CRL2097_foreskin: 0.54, Smooth_muscle_cells:bronchial: 0.54, Smooth_muscle_cells:bronchial:vit_D: 0.53
WK012-G11	Fibroblasts:breast	0.24	473.76	Raw ScoresFibroblasts:breast: 0.48, iPS_cells:adipose_stem_cells: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.46, Smooth_muscle_cells:vascular: 0.46, Osteoblasts: 0.45, Tissue_stem_cells:BM_MSC:TGFb3: 0.45, Smooth_muscle_cells:bronchial: 0.45, Smooth_muscle_cells:bronchial:vit_D: 0.45, Chondrocytes:MSC-derived: 0.45, iPS_cells:CRL2097_foreskin: 0.45
WK012-P10	Chondrocytes:MSC-derived	0.23	466.74	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.5, Osteoblasts: 0.49, Chondrocytes:MSC-derived: 0.49, Smooth_muscle_cells:vascular: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Smooth_muscle_cells:bronchial: 0.48, Smooth_muscle_cells:bronchial:vit_D: 0.48, iPS_cells:CRL2097_foreskin: 0.48
WK014-K12	Fibroblasts:breast	0.23	454.50	Raw ScoresFibroblasts:breast: 0.46, iPS_cells:adipose_stem_cells: 0.45, Osteoblasts: 0.45, Smooth_muscle_cells:vascular:IL-17: 0.45, Tissue_stem_cells:BM_MSC:TGFb3: 0.45, Chondrocytes:MSC-derived: 0.45, Smooth_muscle_cells:vascular: 0.44, iPS_cells:CRL2097_foreskin: 0.44, Tissue_stem_cells:BM_MSC:BMP2: 0.44, Smooth_muscle_cells:bronchial: 0.43
WK012-I10	Fibroblasts:breast	0.24	454.19	Raw ScoresiPS_cells:adipose_stem_cells: 0.49, Fibroblasts:breast: 0.49, Chondrocytes:MSC-derived: 0.49, Osteoblasts: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.48, Smooth_muscle_cells:vascular: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Smooth_muscle_cells:bronchial: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.47
WK036-M19	Fibroblasts:breast	0.24	424.25	Raw ScoresFibroblasts:breast: 0.5, Smooth_muscle_cells:bronchial: 0.49, iPS_cells:adipose_stem_cells: 0.49, Smooth_muscle_cells:bronchial:vit_D: 0.48, Osteoblasts: 0.48, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Chondrocytes:MSC-derived: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Tissue_stem_cells:iliac_MSC: 0.47
WK014-A9	Tissue_stem_cells:BM_MSC	0.20	422.53	Raw ScoresFibroblasts:breast: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.46, iPS_cells:adipose_stem_cells: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.46, Smooth_muscle_cells:vascular: 0.45, Osteoblasts: 0.45, Tissue_stem_cells:BM_MSC:BMP2: 0.45, iPS_cells:CRL2097_foreskin: 0.45, Osteoblasts:BMP2: 0.44, Tissue_stem_cells:BM_MSC: 0.44
WK014-F13	iPS_cells:adipose_stem_cells	0.22	420.42	Raw ScoresFibroblasts:breast: 0.49, iPS_cells:adipose_stem_cells: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.48, Smooth_muscle_cells:vascular: 0.48, Osteoblasts: 0.48, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Osteoblasts:BMP2: 0.47, Chondrocytes:MSC-derived: 0.47, Smooth_muscle_cells:bronchial: 0.47
WK014-P13	Smooth_muscle_cells:vascular	0.20	419.83	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.46, Fibroblasts:breast: 0.46, Smooth_muscle_cells:vascular: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.45, iPS_cells:adipose_stem_cells: 0.45, Tissue_stem_cells:BM_MSC:BMP2: 0.45, Osteoblasts: 0.45, iPS_cells:CRL2097_foreskin: 0.44, Chondrocytes:MSC-derived: 0.44, Osteoblasts:BMP2: 0.44
TM38-H6	Smooth_muscle_cells:vascular:IL-17	0.19	413.06	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.43, Smooth_muscle_cells:vascular: 0.42, Fibroblasts:breast: 0.42, iPS_cells:adipose_stem_cells: 0.41, Tissue_stem_cells:BM_MSC:TGFb3: 0.41, Tissue_stem_cells:BM_MSC:BMP2: 0.41, Osteoblasts:BMP2: 0.4, Osteoblasts: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Chondrocytes:MSC-derived: 0.4
WK014-O8	Smooth_muscle_cells:vascular:IL-17	0.21	411.11	Raw ScoresFibroblasts:breast: 0.48, iPS_cells:adipose_stem_cells: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.47, Smooth_muscle_cells:vascular: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Osteoblasts: 0.46, Tissue_stem_cells:BM_MSC:BMP2: 0.46, Smooth_muscle_cells:bronchial: 0.46, Chondrocytes:MSC-derived: 0.46
TM112-O19	Chondrocytes:MSC-derived	0.20	400.07	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.47, iPS_cells:adipose_stem_cells: 0.47, Fibroblasts:breast: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Chondrocytes:MSC-derived: 0.47, Osteoblasts: 0.47, Osteoblasts:BMP2: 0.46, Smooth_muscle_cells:vascular: 0.46, Tissue_stem_cells:BM_MSC: 0.45
TM112-A3	Fibroblasts:breast	0.22	398.59	Raw ScoresFibroblasts:breast: 0.45, iPS_cells:adipose_stem_cells: 0.44, Osteoblasts: 0.44, Chondrocytes:MSC-derived: 0.44, iPS_cells:CRL2097_foreskin: 0.43, Tissue_stem_cells:BM_MSC:TGFb3: 0.43, Smooth_muscle_cells:vascular: 0.43, Smooth_muscle_cells:bronchial: 0.43, Smooth_muscle_cells:vascular:IL-17: 0.43, Smooth_muscle_cells:bronchial:vit_D: 0.43
TM96-B19	Chondrocytes:MSC-derived	0.22	392.11	Raw ScoresChondrocytes:MSC-derived: 0.52, Osteoblasts: 0.5, iPS_cells:adipose_stem_cells: 0.5, Fibroblasts:breast: 0.5, Smooth_muscle_cells:bronchial: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, Smooth_muscle_cells:bronchial:vit_D: 0.5, iPS_cells:CRL2097_foreskin: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.49, Osteoblasts:BMP2: 0.49
WK036-F12	Fibroblasts:breast	0.24	390.21	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:adipose_stem_cells: 0.51, Osteoblasts: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49, Chondrocytes:MSC-derived: 0.49, Smooth_muscle_cells:vascular: 0.49, iPS_cells:CRL2097_foreskin: 0.49, Osteoblasts:BMP2: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.48
WK014-O10	iPS_cells:adipose_stem_cells	0.23	385.75	Raw ScoresFibroblasts:breast: 0.5, iPS_cells:adipose_stem_cells: 0.5, Osteoblasts: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49, Smooth_muscle_cells:vascular: 0.49, iPS_cells:CRL2097_foreskin: 0.48, Tissue_stem_cells:BM_MSC:TGFb3: 0.48, Tissue_stem_cells:BM_MSC:BMP2: 0.48, Smooth_muscle_cells:bronchial: 0.48, Osteoblasts:BMP2: 0.48

Below shows the significant enrichments of this GEP for literature curated gene lists
This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.94e-13
Mean rank of genes in gene set: 1130.88
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
C7	0.0049521	9	GTEx	DepMap	Descartes	33.04	1506.66
IL1R1	0.0045265	12	GTEx	DepMap	Descartes	6.96	344.84
CXCL2	0.0044151	14	GTEx	DepMap	Descartes	42.48	8440.64
IGF1	0.0041845	18	GTEx	DepMap	Descartes	6.83	194.87
LIF	0.0029922	36	GTEx	DepMap	Descartes	9.18	518.19
C3	0.0028723	45	GTEx	DepMap	Descartes	13.87	728.68
CFD	0.0026305	58	GTEx	DepMap	Descartes	3.93	818.04
SCARA5	0.0019878	112	GTEx	DepMap	Descartes	1.42	78.71
SOD2	0.0017108	149	GTEx	DepMap	Descartes	20.01	339.51
PDGFD	0.0016847	153	GTEx	DepMap	Descartes	1.07	66.73
SERPING1	0.0016327	167	GTEx	DepMap	Descartes	8.82	1003.27
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.90
IL33	0.0012605	261	GTEx	DepMap	Descartes	1.02	87.17
PDGFRB	0.0011201	308	GTEx	DepMap	Descartes	3.91	161.32
PDPN	0.0008714	433	GTEx	DepMap	Descartes	0.74	52.42
GPX3	0.0008585	441	GTEx	DepMap	Descartes	1.75	237.64
IGFBP6	0.0006109	663	GTEx	DepMap	Descartes	1.18	230.90
CXCL12	0.0003411	1142	GTEx	DepMap	Descartes	5.28	327.94
CCL2	0.0002813	1300	GTEx	DepMap	Descartes	30.34	8049.66
SCARA3	0.0002510	1393	GTEx	DepMap	Descartes	0.71	41.24
CXCL14	0.0002362	1455	GTEx	DepMap	Descartes	5.67	647.90
RGMA	0.0000284	2748	GTEx	DepMap	Descartes	0.13	3.63
CFB	0.0000216	2838	GTEx	DepMap	Descartes	0.05	5.47
HGF	-0.0000177	3433	GTEx	DepMap	Descartes	0.55	22.25
IL10	-0.0003464	10908	GTEx	DepMap	Descartes	0.03	5.45

Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.68e-09
Mean rank of genes in gene set: 414.77
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
MGP	0.0044677	13	GTEx	DepMap	Descartes	85.27	13772.01
SPARC	0.0043564	16	GTEx	DepMap	Descartes	97.15	5083.02
BGN	0.0030837	32	GTEx	DepMap	Descartes	26.43	2394.09
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
DCN	0.0025162	65	GTEx	DepMap	Descartes	52.47	1684.07
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
COL6A2	0.0021021	101	GTEx	DepMap	Descartes	14.61	1027.76
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.90
LUM	0.0009055	405	GTEx	DepMap	Descartes	27.51	1956.82
CALD1	0.0001163	2022	GTEx	DepMap	Descartes	8.64	364.79
LEPR	0.0000713	2352	GTEx	DepMap	Descartes	0.35	10.51

Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-06
Mean rank of genes in gene set: 4068.08
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL14A1	0.0057922	4	GTEx	DepMap	Descartes	17.57	538.62
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
MMP2	0.0042331	17	GTEx	DepMap	Descartes	9.61	638.66
BGN	0.0030837	32	GTEx	DepMap	Descartes	26.43	2394.09
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
VEGFA	0.0028868	43	GTEx	DepMap	Descartes	7.40	152.45
COL5A1	0.0026552	57	GTEx	DepMap	Descartes	9.15	230.59
IGFBP3	0.0025256	64	GTEx	DepMap	Descartes	3.06	282.00
DCN	0.0025162	65	GTEx	DepMap	Descartes	52.47	1684.07
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80
VCAN	0.0022721	85	GTEx	DepMap	Descartes	12.89	251.23
THBS2	0.0021658	96	GTEx	DepMap	Descartes	11.02	387.49
TMEM119	0.0019363	119	GTEx	DepMap	Descartes	2.34	184.89
COL8A1	0.0018357	135	GTEx	DepMap	Descartes	4.94	165.65
COL5A2	0.0018081	141	GTEx	DepMap	Descartes	6.16	168.95
THY1	0.0014822	202	GTEx	DepMap	Descartes	4.12	196.38
TAGLN	0.0012942	253	GTEx	DepMap	Descartes	14.32	924.82
THBS1	0.0011814	280	GTEx	DepMap	Descartes	23.10	877.16
COL12A1	0.0011701	284	GTEx	DepMap	Descartes	4.92	91.28
TPM1	0.0009752	364	GTEx	DepMap	Descartes	4.51	239.21
LUM	0.0009055	405	GTEx	DepMap	Descartes	27.51	1956.82
TGFBR1	0.0008729	432	GTEx	DepMap	Descartes	1.27	43.29
MYLK	0.0008226	474	GTEx	DepMap	Descartes	3.28	68.00
COL11A1	0.0005547	733	GTEx	DepMap	Descartes	0.95	15.49
WNT5A	0.0005450	751	GTEx	DepMap	Descartes	0.12	3.27
TGFB2	0.0004749	875	GTEx	DepMap	Descartes	0.61	21.83
CNN3	0.0003266	1180	GTEx	DepMap	Descartes	2.85	313.83
COL10A1	0.0003049	1245	GTEx	DepMap	Descartes	0.86	39.68
TPM2	0.0000395	2621	GTEx	DepMap	Descartes	2.77	407.33
MYL9	0.0000332	2693	GTEx	DepMap	Descartes	4.93	384.01
MMP11	0.0000085	3003	GTEx	DepMap	Descartes	0.39	21.96
ACTA2	-0.0001419	6521	GTEx	DepMap	Descartes	8.17	1438.87
HOPX	-0.0001594	7019	GTEx	DepMap	Descartes	0.28	21.54
COL15A1	-0.0001692	7295	GTEx	DepMap	Descartes	1.88	78.80
CNN2	-0.0001823	7640	GTEx	DepMap	Descartes	1.74	159.51
COL13A1	-0.0001847	7698	GTEx	DepMap	Descartes	0.02	0.80
TNC	-0.0002018	8141	GTEx	DepMap	Descartes	2.68	77.08
POSTN	-0.0002268	8756	GTEx	DepMap	Descartes	5.53	312.48
ACTG2	-0.0002663	9623	GTEx	DepMap	Descartes	0.50	70.73
IGFBP7	-0.0002918	10131	GTEx	DepMap	Descartes	58.65	8991.02
ITGA7	-0.0004070	11517	GTEx	DepMap	Descartes	0.37	20.85
MEF2C	-0.0005077	12062	GTEx	DepMap	Descartes	0.34	8.70
TGFB1	-0.0005097	12068	GTEx	DepMap	Descartes	0.46	38.45
MYH11	-0.0005141	12087	GTEx	DepMap	Descartes	1.22	39.48
COL4A1	-0.0005974	12312	GTEx	DepMap	Descartes	6.44	233.65
TGFBR2	-0.0006112	12329	GTEx	DepMap	Descartes	1.70	56.42
FN1	-0.0006169	12340	GTEx	DepMap	Descartes	16.84	370.18
PGF	-0.0007877	12485	GTEx	DepMap	Descartes	0.16	7.49
RGS5	-0.0011002	12538	GTEx	DepMap	Descartes	4.51	143.66

Bridge region mesencchymal (Olsen)
Marker genes shown in Fig. 3A of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - Cells were ordered by pseudotime in the bridge region, this first group of cells were from the mesenchymal part of the trajectory.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.92e-05
Mean rank of genes in gene set: 2239
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BGN	0.0030837	32	GTEx	DepMap	Descartes	26.43	2394.09
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
MYC	0.0017208	147	GTEx	DepMap	Descartes	3.86	247.29
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.90
KLF4	0.0012087	272	GTEx	DepMap	Descartes	6.22	508.90
LUM	0.0009055	405	GTEx	DepMap	Descartes	27.51	1956.82
NPNT	0.0005917	683	GTEx	DepMap	Descartes	0.30	14.35
MAFF	0.0003943	1016	GTEx	DepMap	Descartes	4.87	344.12
CALD1	0.0001163	2022	GTEx	DepMap	Descartes	8.64	364.79
TNNT2	-0.0000383	3840	GTEx	DepMap	Descartes	0.02	1.39
FGF1	-0.0002218	8652	GTEx	DepMap	Descartes	0.08	3.65
PODXL	-0.0004400	11731	GTEx	DepMap	Descartes	0.13	2.64

Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.00e-04
Mean rank of genes in gene set: 2688.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL14A1	0.0057922	4	GTEx	DepMap	Descartes	17.57	538.62
FBN1	0.0025472	61	GTEx	DepMap	Descartes	5.38	97.78
FSTL1	0.0020865	104	GTEx	DepMap	Descartes	9.63	353.78
COL5A2	0.0018081	141	GTEx	DepMap	Descartes	6.16	168.95
SFRP1	0.0010606	327	GTEx	DepMap	Descartes	2.00	82.76
GAS1	0.0009812	360	GTEx	DepMap	Descartes	1.40	113.77
GSN	0.0007021	567	GTEx	DepMap	Descartes	11.79	504.60
PENK	0.0001110	2054	GTEx	DepMap	Descartes	0.16	48.22
ITM2A	0.0001008	2129	GTEx	DepMap	Descartes	1.83	236.40
IGFBP5	-0.0000979	5301	GTEx	DepMap	Descartes	15.34	572.17
POSTN	-0.0002268	8756	GTEx	DepMap	Descartes	5.53	312.48
FBN2	-0.0007225	12454	GTEx	DepMap	Descartes	0.08	1.70

Stromal 1 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.64e-04
Mean rank of genes in gene set: 1649.29
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP14	0.0022014	93	GTEx	DepMap	Descartes	3.15	194.03
NFIB	0.0017388	144	GTEx	DepMap	Descartes	5.41	144.41
COL27A1	0.0009018	409	GTEx	DepMap	Descartes	0.98	33.29
TGFB2	0.0004749	875	GTEx	DepMap	Descartes	0.61	21.83
HMGA2	0.0001427	1862	GTEx	DepMap	Descartes	0.10	3.06
CHD3	0.0000171	2896	GTEx	DepMap	Descartes	1.36	47.58
IGSF3	-0.0000968	5266	GTEx	DepMap	Descartes	0.07	2.08

Mesenchymal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.93e-04
Mean rank of genes in gene set: 194.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
COL6A1	0.0012539	265	GTEx	DepMap	Descartes	14.96	875.25
VIM	0.0008371	460	GTEx	DepMap	Descartes	50.48	4574.75

Subepicardial mesenchyme (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.05e-04
Mean rank of genes in gene set: 1957.14
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
TWIST2	0.0008795	427	GTEx	DepMap	Descartes	0.66	116.85
TWIST1	0.0004148	981	GTEx	DepMap	Descartes	0.91	124.80
TBX18	-0.0005131	12082	GTEx	DepMap	Descartes	0.20	6.38

Mesenchymal (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being expressed in a group of mesenchymal-like cells (some at least claimed to be neuroblastoma cells) shown in their UMAP representation on Fig. 1D. They reference the two Nature Genetics paper.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-04
Mean rank of genes in gene set: 670.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DCN	0.0025162	65	GTEx	DepMap	Descartes	52.47	1684.07
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.90
LEPR	0.0000713	2352	GTEx	DepMap	Descartes	0.35	10.51

Mesenchymal cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that COL1A1+ Mesenchymal were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.67e-03
Mean rank of genes in gene set: 139.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80
PDGFRB	0.0011201	308	GTEx	DepMap	Descartes	3.91	161.32

p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.03e-02
Mean rank of genes in gene set: 345.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDKN1A	0.0029028	40	GTEx	DepMap	Descartes	20.30	2082.46
NEAT1	0.0006207	651	GTEx	DepMap	Descartes	42.92	501.95

EpiSen (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, an epithelial senescence associated program.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.31e-02
Mean rank of genes in gene set: 2248.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLPI	0.0001194	2002	GTEx	DepMap	Descartes	0.02	11.71
CLDN4	0.0000902	2213	GTEx	DepMap	Descartes	0.01	0.31
LCN2	0.0000900	2216	GTEx	DepMap	Descartes	0.00	0.00
AQP3	0.0000455	2564	GTEx	DepMap	Descartes	0.22	18.07

Inflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.38e-02
Mean rank of genes in gene set: 85
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	0.0022721	85	GTEx	DepMap	Descartes	12.89	251.23

Mixed phenotype identified at the fate split point mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells. markers are of the split point where SCPs differentiate.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.39e-02
Mean rank of genes in gene set: 89
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98

Mesemchymal validated (Olsen)
Stated on pages 7 and 8 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is stated that a mesenchymal-like neuroblastoma cell state is validate by combined immunofluorescence staining for PDGFRA and FISH for PPMID gain, a gene on 17q.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.61e-02
Mean rank of genes in gene set: 176
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.9

Protein maturation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.79e-02
Mean rank of genes in gene set: 2791
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDIA3	0.0004059	1000	GTEx	DepMap	Descartes	2.37	141.06
OS9	0.0003586	1095	GTEx	DepMap	Descartes	1.88	111.13
RPN2	-0.0001333	6278	GTEx	DepMap	Descartes	1.29	124.13

Mesenchymal (Kildisiute)
Mesenchymal markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.98e-02
Mean rank of genes in gene set: 308
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0011201	308	GTEx	DepMap	Descartes	3.91	161.32

EMT II (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in HNSCC cell lines:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.56e-02
Mean rank of genes in gene set: 3390
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL5A1	0.0026552	57	GTEx	DepMap	Descartes	9.15	230.59
VIM	0.0008371	460	GTEx	DepMap	Descartes	50.48	4574.75
AXL	0.0005792	703	GTEx	DepMap	Descartes	1.96	89.76
FN1	-0.0006169	12340	GTEx	DepMap	Descartes	16.84	370.18

Endothelium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.69e-02
Mean rank of genes in gene set: 843
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	0.0004911	843	GTEx	DepMap	Descartes	5.63	399.48

Pigmentation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, Skin pigmentation genes, identified in melanoma.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.94e-02
Mean rank of genes in gene set: 3840.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MITF	3.29e-05	2697	GTEx	DepMap	Descartes	0.42	20.11
DCT	-2.97e-05	3667	GTEx	DepMap	Descartes	0.00	0.12
MLANA	-4.76e-05	4036	GTEx	DepMap	Descartes	0.00	0.35
PMEL	-8.46e-05	4961	GTEx	DepMap	Descartes	0.01	0.76

Muscle progenitor (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PAX7+ Muscle progenitor were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.07e-01
Mean rank of genes in gene set: 3092.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDON	0.0003726	1064	GTEx	DepMap	Descartes	0.28	6.15
PAX7	-0.0000910	5121	GTEx	DepMap	Descartes	0.00	0.00

Melanocytes (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.16e-01
Mean rank of genes in gene set: 3775
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MITF	3.29e-05	2697	GTEx	DepMap	Descartes	0.42	20.11
DCT	-2.97e-05	3667	GTEx	DepMap	Descartes	0.00	0.12
PMEL	-8.46e-05	4961	GTEx	DepMap	Descartes	0.01	0.76

Nerves and neurofiliment (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - NF200 is expressed in neurofiliments and is found close to SCPs in normal tissue, NRG1 is secreted by neurons, to which ERBB3 (on glia) binds.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.37e-01
Mean rank of genes in gene set: 2311
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	7.66e-05	2311	GTEx	DepMap	Descartes	0.13	2.31

Stroma (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Stroma cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.92e-01
Mean rank of genes in gene set: 4865.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
COL5A1	0.0026552	57	GTEx	DepMap	Descartes	9.15	230.59
COL6A1	0.0012539	265	GTEx	DepMap	Descartes	14.96	875.25
GPC3	-0.0004262	11655	GTEx	DepMap	Descartes	1.21	139.32
FN1	-0.0006169	12340	GTEx	DepMap	Descartes	16.84	370.18

Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.21e-01
Mean rank of genes in gene set: 4670.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A10	0.0008804	426	GTEx	DepMap	Descartes	4.10	1655.80
IFITM3	0.0003843	1038	GTEx	DepMap	Descartes	21.87	8426.03
B2M	-0.0014897	12547	GTEx	DepMap	Descartes	24.43	2224.21

Liver Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.27e-01
Mean rank of genes in gene set: 4356
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VTN	-2.93e-05	3654	GTEx	DepMap	Descartes	0	1.03
AHSG	-8.82e-05	5058	GTEx	DepMap	Descartes	0	0.00

Bridge (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.33e-01
Mean rank of genes in gene set: 4753
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB4	0.0001269	1953	GTEx	DepMap	Descartes	0.04	1.14
CDH9	-0.0000662	4500	GTEx	DepMap	Descartes	0.00	0.08
CTTNBP2	-0.0001891	7806	GTEx	DepMap	Descartes	0.01	0.22

Endothelial Cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.66e-01
Mean rank of genes in gene set: 4671.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ENG	0.0001506	1811	GTEx	DepMap	Descartes	2.63	187.60
VWF	-0.0001775	7532	GTEx	DepMap	Descartes	1.78	24.39

Adrenal cortex (Kildisiute)
Adrenal cortex markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.66e-01
Mean rank of genes in gene set: 4014
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-4.65e-05	4014	GTEx	DepMap	Descartes	0.03	2.32

Adrenal gland cortex (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.66e-01
Mean rank of genes in gene set: 4014
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-4.65e-05	4014	GTEx	DepMap	Descartes	0.03	2.32

Hepatocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ALB+ Hepatocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D. The main text also speculated that these hepatocytes were probably derived from neighboring tissue, and hence artifactual, but there is no evidence presented for this.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.99e-01
Mean rank of genes in gene set: 4924
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ASGR1	8.84e-05	2230	GTEx	DepMap	Descartes	0.18	28.23
ALB	-1.81e-04	7618	GTEx	DepMap	Descartes	0.00	0.00

Erythroid cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.39e-01
Mean rank of genes in gene set: 4772
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALAS2	-7.71e-05	4772	GTEx	DepMap	Descartes	0	0

Committed Progenitor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Committed Progenitor subcluster (seems to mean progenitor of chromaffin cells), which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.50e-01
Mean rank of genes in gene set: 5915
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRK	0.0012912	255	GTEx	DepMap	Descartes	0.34	12.31
MEG3	0.0009456	387	GTEx	DepMap	Descartes	9.59	213.22
ATP6V1B2	0.0004447	926	GTEx	DepMap	Descartes	3.17	89.38
ZDBF2	0.0000747	2330	GTEx	DepMap	Descartes	0.38	8.42
RGS4	0.0000607	2442	GTEx	DepMap	Descartes	1.26	72.37
PARM1	0.0000151	2924	GTEx	DepMap	Descartes	0.44	21.35
UNC5C	-0.0000340	3748	GTEx	DepMap	Descartes	0.10	2.65
NTRK3	-0.0000887	5067	GTEx	DepMap	Descartes	0.57	6.50
FAM155A	-0.0001879	7780	GTEx	DepMap	Descartes	0.12	2.66
SYTL4	-0.0002146	8473	GTEx	DepMap	Descartes	0.18	7.98
SLC18A2	-0.0002311	8858	GTEx	DepMap	Descartes	0.04	2.56
DGKK	-0.0002334	8912	GTEx	DepMap	Descartes	0.01	0.26
SYT1	-0.0004161	11588	GTEx	DepMap	Descartes	0.04	1.52
NDUFA4L2	-0.0008157	12497	GTEx	DepMap	Descartes	0.12	21.50
RGS5	-0.0011002	12538	GTEx	DepMap	Descartes	4.51	143.66

Mesencchymal populations mouse (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.81e-01
Mean rank of genes in gene set: 5498
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
FLI1	-0.0003463	10907	GTEx	DepMap	Descartes	0.11	4.20

Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.93e-01
Mean rank of genes in gene set: 5783.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NPM1	0.0013290	243	GTEx	DepMap	Descartes	8.99	1194.85
TPI1	0.0001070	2085	GTEx	DepMap	Descartes	3.50	456.96
MIF	-0.0003019	10305	GTEx	DepMap	Descartes	0.24	48.49
TK1	-0.0003154	10500	GTEx	DepMap	Descartes	0.01	0.36

Antigen Presenting CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain antigen presenting specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.30e-01
Mean rank of genes in gene set: 6090.08
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A10	0.0008804	426	GTEx	DepMap	Descartes	4.10	1655.80
S100A13	0.0008576	442	GTEx	DepMap	Descartes	0.89	102.30
KRT18	0.0003493	1125	GTEx	DepMap	Descartes	0.50	55.10
SLPI	0.0001194	2002	GTEx	DepMap	Descartes	0.02	11.71
KRT8	0.0000084	3007	GTEx	DepMap	Descartes	0.11	7.83
UPK3B	-0.0000278	3628	GTEx	DepMap	Descartes	0.00	0.09
S100A3	-0.0000583	4305	GTEx	DepMap	Descartes	0.01	2.38
S100A4	-0.0002877	10052	GTEx	DepMap	Descartes	0.96	354.52
KRT19	-0.0004095	11539	GTEx	DepMap	Descartes	0.02	1.64
CD83	-0.0004524	11793	GTEx	DepMap	Descartes	0.70	50.45
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16
CD74	-0.0007647	12477	GTEx	DepMap	Descartes	6.62	451.39

Bridge (Kildisiute)
Bridge cell (cites Furlan 2017) markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.73e-01
Mean rank of genes in gene set: 6030
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DLL3	-0.0001237	6030	GTEx	DepMap	Descartes	0.01	0.54

Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.76e-01
Mean rank of genes in gene set: 6123.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EZH2	0.0000232	2813	GTEx	DepMap	Descartes	0.55	35.02
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09

Stress response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.83e-01
Mean rank of genes in gene set: 6207.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GADD45A	0.0016879	152	GTEx	DepMap	Descartes	5.98	994.06
SQSTM1	0.0011900	276	GTEx	DepMap	Descartes	12.40	955.39
GADD45B	-0.0001110	5690	GTEx	DepMap	Descartes	5.01	599.07
ATF3	-0.0006936	12428	GTEx	DepMap	Descartes	5.06	599.75
DDIT3	-0.0008010	12492	GTEx	DepMap	Descartes	0.31	68.37

EMT I melanoma (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was melanoma specific.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.90e-01
Mean rank of genes in gene set: 6222
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPM1	0.0009752	364	GTEx	DepMap	Descartes	4.51	239.21
CAV1	-0.0002157	8498	GTEx	DepMap	Descartes	2.78	163.55
RRAS	-0.0002750	9804	GTEx	DepMap	Descartes	0.54	109.20

SCPs neuroblastoma unique (Olsen)
Similar to above, but for genes unique to neuroblastoma SCP-like cells. Note FN1 is often used as a mesenchymal marker gene.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.93e-01
Mean rank of genes in gene set: 6247.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TIMP3	0.0010126	346	GTEx	DepMap	Descartes	13.92	754.64
IFITM3	0.0003843	1038	GTEx	DepMap	Descartes	21.87	8426.03
ANXA1	0.0002371	1452	GTEx	DepMap	Descartes	11.04	1165.17
ITGB8	-0.0003406	10817	GTEx	DepMap	Descartes	0.27	4.43
GFRA3	-0.0004039	11491	GTEx	DepMap	Descartes	0.10	5.58
FN1	-0.0006169	12340	GTEx	DepMap	Descartes	16.84	370.18

Chromaffin cell-like (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.95e-01
Mean rank of genes in gene set: 6240.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NPY	-9.04e-05	5103	GTEx	DepMap	Descartes	0.35	254.85
NTRK1	-1.72e-04	7378	GTEx	DepMap	Descartes	0.01	0.44

Myofibroblasts (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ACTA2+ Myofibroblasts were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.02e-01
Mean rank of genes in gene set: 6287
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TAGLN	0.0012942	253	GTEx	DepMap	Descartes	14.32	924.82
ACTA2	-0.0001419	6521	GTEx	DepMap	Descartes	8.17	1438.87
MYH11	-0.0005141	12087	GTEx	DepMap	Descartes	1.22	39.48

Definitive Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Definitive Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.25e-01
Mean rank of genes in gene set: 6386.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPE	0.0023927	75	GTEx	DepMap	Descartes	5.41	496.98
CALN1	-0.0001067	5565	GTEx	DepMap	Descartes	0.00	0.00
GREB1	-0.0002794	9892	GTEx	DepMap	Descartes	0.04	0.94
CHCHD10	-0.0002857	10013	GTEx	DepMap	Descartes	0.45	89.44

PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.73e-01
Mean rank of genes in gene set: 6440.81
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTGS2	0.0019125	122	GTEx	DepMap	Descartes	6.20	282.41
CSF1	0.0018320	136	GTEx	DepMap	Descartes	2.65	178.35
TNFRSF10B	0.0010491	329	GTEx	DepMap	Descartes	1.78	96.50
STAT3	0.0002696	1329	GTEx	DepMap	Descartes	5.25	254.30
ANXA1	0.0002371	1452	GTEx	DepMap	Descartes	11.04	1165.17
HIF1A	0.0001826	1665	GTEx	DepMap	Descartes	3.13	184.69
ARG1	-0.0000631	4421	GTEx	DepMap	Descartes	0.00	0.00
STAT6	-0.0001088	5629	GTEx	DepMap	Descartes	1.12	65.68
SLC27A2	-0.0001166	5836	GTEx	DepMap	Descartes	0.00	0.00
ARG2	-0.0002784	9872	GTEx	DepMap	Descartes	0.12	15.10
STAT1	-0.0003991	11451	GTEx	DepMap	Descartes	0.97	58.13
CD84	-0.0004354	11703	GTEx	DepMap	Descartes	0.08	1.61
TGFB1	-0.0005097	12068	GTEx	DepMap	Descartes	0.46	38.45
IL1B	-0.0005948	12309	GTEx	DepMap	Descartes	0.33	59.46
IRF1	-0.0005988	12313	GTEx	DepMap	Descartes	2.68	130.28
CD36	-0.0006875	12418	GTEx	DepMap	Descartes	0.19	4.27

Bridge (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Bridge subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.78e-01
Mean rank of genes in gene set: 6479.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DPYSL3	0.0016161	171	GTEx	DepMap	Descartes	2.64	106.00
RCC2	0.0003721	1065	GTEx	DepMap	Descartes	1.05	56.69
CKB	0.0003299	1172	GTEx	DepMap	Descartes	1.31	259.43
NFASC	0.0000808	2282	GTEx	DepMap	Descartes	0.47	11.72
WDR6	-0.0000423	3926	GTEx	DepMap	Descartes	0.70	39.06
TBX20	-0.0000973	5281	GTEx	DepMap	Descartes	0.00	0.00
DLL3	-0.0001237	6030	GTEx	DepMap	Descartes	0.01	0.54
GSE1	-0.0002307	8842	GTEx	DepMap	Descartes	0.47	NA
MIAT	-0.0004772	11921	GTEx	DepMap	Descartes	0.05	1.36
SOX11	-0.0006056	12319	GTEx	DepMap	Descartes	0.05	1.12
CDKN1C	-0.0006105	12327	GTEx	DepMap	Descartes	1.06	114.58
LDHB	-0.0006877	12420	GTEx	DepMap	Descartes	1.06	151.31

Bridge region SCP-like (Olsen)
As above but for the SCP-like region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.21e-01
Mean rank of genes in gene set: 6835.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FXYD1	0.0007137	561	GTEx	DepMap	Descartes	0.93	306.54
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
S100B	-0.0003082	10393	GTEx	DepMap	Descartes	0.51	49.88
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76

Axon guidance (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for axon guidance instead of myelination:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.37e-01
Mean rank of genes in gene set: 7543
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SEMA3B	-0.0001782	7543	GTEx	DepMap	Descartes	0.31	19.66

B cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.42e-01
Mean rank of genes in gene set: 7596
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-0.0001801	7596	GTEx	DepMap	Descartes	0.02	6.77

EMT III (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in non-cycling cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.48e-01
Mean rank of genes in gene set: 6964.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2	0.0002061	1565	GTEx	DepMap	Descartes	0.36	13.61
LAMB3	-0.0001502	6779	GTEx	DepMap	Descartes	0.02	1.07
LAMA3	-0.0001784	7550	GTEx	DepMap	Descartes	0.10	2.27
JUP	-0.0004860	11963	GTEx	DepMap	Descartes	0.22	13.38

SCPs mouse unique (Olsen)
Selected list of SCP marker genes shown in Fig. 2B of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these genes were unique to mouse SCPs as determined by the linearge tracing study Furlan et al. (Science 2017, PMID 28684471).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.49e-01
Mean rank of genes in gene set: 6966
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCRG1	-0.0000222	3518	GTEx	DepMap	Descartes	0.13	7.81
CRABP1	-0.0000416	3910	GTEx	DepMap	Descartes	0.04	18.61
POSTN	-0.0002268	8756	GTEx	DepMap	Descartes	5.53	312.48
H1FX	-0.0004304	11680	GTEx	DepMap	Descartes	1.55	NA

Myocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that MYH3+ Myocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.99e-01
Mean rank of genes in gene set: 7608
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYH3	-0.0000614	4381	GTEx	DepMap	Descartes	0.01	0.70
TTN	-0.0003418	10835	GTEx	DepMap	Descartes	0.11	0.31

Pre-E Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Pre Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.00e-01
Mean rank of genes in gene set: 6824.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLE1	0.0002344	1460	GTEx	DepMap	Descartes	0.81	42.92
LRP11	0.0002082	1557	GTEx	DepMap	Descartes	0.22	12.56
SLC31A1	0.0001844	1656	GTEx	DepMap	Descartes	0.25	10.76
RPS6KA6	0.0000085	3002	GTEx	DepMap	Descartes	0.06	1.16
SLC38A4	-0.0000392	3859	GTEx	DepMap	Descartes	0.00	0.21
FAM163A	-0.0001713	7362	GTEx	DepMap	Descartes	0.00	0.00
ARNT2	-0.0001760	7486	GTEx	DepMap	Descartes	0.02	0.66
PCP4	-0.0001842	7687	GTEx	DepMap	Descartes	0.00	NA
NELFCD	-0.0003528	10976	GTEx	DepMap	Descartes	0.34	NA
TMX4	-0.0004600	11826	GTEx	DepMap	Descartes	0.72	23.46
ARHGEF28	-0.0007858	12483	GTEx	DepMap	Descartes	0.06	NA
JUN	-0.0010866	12537	GTEx	DepMap	Descartes	6.62	507.36

Schwann cell Precursor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the SCP subcluster, which is part of the Adrenal Medulla cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.27e-01
Mean rank of genes in gene set: 6933.91
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SERPINE2	0.0026950	53	GTEx	DepMap	Descartes	3.73	124.63
CST3	0.0016582	160	GTEx	DepMap	Descartes	15.01	1068.58
LMO4	0.0000871	2238	GTEx	DepMap	Descartes	2.90	135.66
DAGLA	-0.0000468	4018	GTEx	DepMap	Descartes	0.03	1.19
TTYH1	-0.0001631	7125	GTEx	DepMap	Descartes	0.02	0.85
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
CHL1	-0.0002712	9716	GTEx	DepMap	Descartes	0.21	5.12
PTPRZ1	-0.0002897	10086	GTEx	DepMap	Descartes	0.09	1.29
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76
CNP	-0.0003483	10939	GTEx	DepMap	Descartes	0.72	29.88
NGFR	-0.0005475	12200	GTEx	DepMap	Descartes	1.57	112.99

Chromaffin cells Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for chromaffin cells (differentiating from symphathoblasts):
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.47e-01
Mean rank of genes in gene set: 7669
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0001110	2054	GTEx	DepMap	Descartes	0.16	48.22
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88
CHGB	-0.0003637	11112	GTEx	DepMap	Descartes	0.15	13.25

M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.50e-01
Mean rank of genes in gene set: 7198.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VEGFA	0.0028868	43	GTEx	DepMap	Descartes	7.40	152.45
IL13	0.0000019	3114	GTEx	DepMap	Descartes	0.00	0.18
ARG1	-0.0000631	4421	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002500	9269	GTEx	DepMap	Descartes	0.31	37.41
CD163	-0.0003200	10566	GTEx	DepMap	Descartes	0.16	3.52
IL10	-0.0003464	10908	GTEx	DepMap	Descartes	0.03	5.45
TGFB1	-0.0005097	12068	GTEx	DepMap	Descartes	0.46	38.45

Normal Schwann cell precurors, but not Neuroblastoma Scps (Olsen)
Based on their neuroblastoma data and stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.53e-01
Mean rank of genes in gene set: 8756
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	-0.0002268	8756	GTEx	DepMap	Descartes	5.53	312.48

Schwann cell precursors (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.85e-01
Mean rank of genes in gene set: 9133
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.8

Schwann cell precursors (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. The authors data suggest these SCPs can give rise to symphathoblasts, which can then give rise to chromaffin cells. However, these SCPs can also directly give rise to chromaffin cells (i.e there are two bridges/paths).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.85e-01
Mean rank of genes in gene set: 9133
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.8

Meta_7 undefined sympathetic (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.94e-01
Mean rank of genes in gene set: 7987.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TUBB2A	-0.0000312	3691	GTEx	DepMap	Descartes	1.81	249.20
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34

Myelination (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are state as being involved in Myelination and are expressed in the Schwann cell precursor cluster of their UMAP (Fig. 1D), these are suggested to represent more mature myelinating Schwann cells. MPZ is Myelin Protien Zero.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.01e-01
Mean rank of genes in gene set: 8438
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
LGI4	-0.0003626	11094	GTEx	DepMap	Descartes	0.18	9.47

SCPs mouse and neuroblastoma (Olsen)
Similar to above, but for genes common to neuroblastoma SCP-like cells (as determined from their UMAP plot) and mouse SCP cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.09e-01
Mean rank of genes in gene set: 7230.45
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FXYD1	0.0007137	561	GTEx	DepMap	Descartes	0.93	306.54
DST	0.0004344	942	GTEx	DepMap	Descartes	4.30	48.45
CNN3	0.0003266	1180	GTEx	DepMap	Descartes	2.85	313.83
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
SEMA3B	-0.0001782	7543	GTEx	DepMap	Descartes	0.31	19.66
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
S100B	-0.0003082	10393	GTEx	DepMap	Descartes	0.51	49.88
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76
GPM6B	-0.0003320	10708	GTEx	DepMap	Descartes	0.25	9.21
LGI4	-0.0003626	11094	GTEx	DepMap	Descartes	0.18	9.47
NRXN1	-0.0004172	11594	GTEx	DepMap	Descartes	0.14	1.91

Angioblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Angioblast subcluster of Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.13e-01
Mean rank of genes in gene set: 8137.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAP4K4	0.0002129	1541	GTEx	DepMap	Descartes	1.93	65.26
NES	-0.0003258	10624	GTEx	DepMap	Descartes	1.11	46.78
PREX1	-0.0005695	12248	GTEx	DepMap	Descartes	0.07	1.55

Erythrocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that HBA2+ Erythrocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.29e-01
Mean rank of genes in gene set: 9720
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK1	-0.0002714	9720	GTEx	DepMap	Descartes	0.06	1.23

Symphathoadrenal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.38e-01
Mean rank of genes in gene set: 9841
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88

Stromal 3 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.45e-01
Mean rank of genes in gene set: 8395.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OLFML3	0.0011625	290	GTEx	DepMap	Descartes	2.32	231.62
PIK3R1	-0.0006412	12376	GTEx	DepMap	Descartes	0.62	20.16
NOTCH3	-0.0009134	12521	GTEx	DepMap	Descartes	2.15	57.71

Stress response (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.50e-01
Mean rank of genes in gene set: 8438.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
JUNB	0.0013579	234	GTEx	DepMap	Descartes	21.86	2888.47
JUN	-0.0010866	12537	GTEx	DepMap	Descartes	6.62	507.36
FOS	-0.0012900	12545	GTEx	DepMap	Descartes	10.76	1347.60

Schwann cell precursor (Kildisiute)
SCP markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.57e-01
Mean rank of genes in gene set: 8506.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76

Schwann cell precursors (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.57e-01
Mean rank of genes in gene set: 8506.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76

M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.72e-01
Mean rank of genes in gene set: 7337.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VEGFA	0.0028868	43	GTEx	DepMap	Descartes	7.40	152.45
TNFRSF10B	0.0010491	329	GTEx	DepMap	Descartes	1.78	96.50
STAT3	0.0002696	1329	GTEx	DepMap	Descartes	5.25	254.30
HIF1A	0.0001826	1665	GTEx	DepMap	Descartes	3.13	184.69
ARG1	-0.0000631	4421	GTEx	DepMap	Descartes	0.00	0.00
CD274	-0.0001151	5795	GTEx	DepMap	Descartes	0.06	4.15
NOS2	-0.0001302	6204	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002500	9269	GTEx	DepMap	Descartes	0.31	37.41
ARG2	-0.0002784	9872	GTEx	DepMap	Descartes	0.12	15.10
IL10	-0.0003464	10908	GTEx	DepMap	Descartes	0.03	5.45
CD84	-0.0004354	11703	GTEx	DepMap	Descartes	0.08	1.61
TNF	-0.0004401	11732	GTEx	DepMap	Descartes	0.07	6.22
TGFB1	-0.0005097	12068	GTEx	DepMap	Descartes	0.46	38.45
IL1B	-0.0005948	12309	GTEx	DepMap	Descartes	0.33	59.46
CD36	-0.0006875	12418	GTEx	DepMap	Descartes	0.19	4.27

Chromaffin (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. These markers are expressed at a lower level in symphathoblasts.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.74e-01
Mean rank of genes in gene set: 9208.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88

Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.81e-01
Mean rank of genes in gene set: 8737.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EIF3L	-0.0000825	4907	GTEx	DepMap	Descartes	2.48	156.96
EIF3F	-0.0003098	10420	GTEx	DepMap	Descartes	1.22	36.23
EIF3E	-0.0003447	10886	GTEx	DepMap	Descartes	1.87	192.89

Adrenergic (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for adrenergic genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.96e-01
Mean rank of genes in gene set: 9503
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34

Fetal Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Fetal Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.03e-01
Mean rank of genes in gene set: 10987
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRAMD1B	-0.0003542	10987	GTEx	DepMap	Descartes	0.05	1.4

E Chromaffin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.05e-01
Mean rank of genes in gene set: 8212.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NPY	-0.0000904	5103	GTEx	DepMap	Descartes	0.35	254.85
DLK1	-0.0000945	5203	GTEx	DepMap	Descartes	0.22	12.72
ANK3	-0.0001455	6633	GTEx	DepMap	Descartes	0.40	5.25
RAB3B	-0.0002997	10267	GTEx	DepMap	Descartes	0.03	0.57
RAB3C	-0.0003183	10545	GTEx	DepMap	Descartes	0.01	0.16
GATA2	-0.0004072	11523	GTEx	DepMap	Descartes	0.12	5.31

Adrenergic mature (olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These markers are specific to the mature adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.13e-01
Mean rank of genes in gene set: 9764
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0001720	7378	GTEx	DepMap	Descartes	0.01	0.44
GAP43	-0.0005305	12150	GTEx	DepMap	Descartes	0.07	5.76

Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-01
Mean rank of genes in gene set: 8788.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRCP	0.0000707	2359	GTEx	DepMap	Descartes	0.89	25.04
EGFL7	-0.0002537	9359	GTEx	DepMap	Descartes	0.07	5.12
KDR	-0.0004031	11484	GTEx	DepMap	Descartes	0.04	0.69
FLT1	-0.0004839	11953	GTEx	DepMap	Descartes	0.26	5.20

Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.26e-01
Mean rank of genes in gene set: 7443.3
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FBLN2	0.0030609	34	GTEx	DepMap	Descartes	4.66	258.03
IGFBP3	0.0025256	64	GTEx	DepMap	Descartes	3.06	282.00
THBD	0.0011181	309	GTEx	DepMap	Descartes	3.13	203.98
GJA1	0.0008139	482	GTEx	DepMap	Descartes	1.74	112.14
ADAMTS1	0.0005843	700	GTEx	DepMap	Descartes	6.21	268.37
CLIC4	0.0000973	2153	GTEx	DepMap	Descartes	2.73	134.99
TM4SF1	0.0000938	2184	GTEx	DepMap	Descartes	7.80	491.02
DUSP6	-0.0001903	7835	GTEx	DepMap	Descartes	2.64	147.89
MECOM	-0.0002043	8201	GTEx	DepMap	Descartes	0.04	1.16
SHROOM2	-0.0002720	9736	GTEx	DepMap	Descartes	0.05	1.04
CDK1	-0.0003112	10436	GTEx	DepMap	Descartes	0.01	0.54
LFNG	-0.0003397	10807	GTEx	DepMap	Descartes	0.06	5.84
MCF2L	-0.0003624	11087	GTEx	DepMap	Descartes	0.03	1.57
SPRY1	-0.0003864	11342	GTEx	DepMap	Descartes	0.62	53.32
FAM102A	-0.0004372	11714	GTEx	DepMap	Descartes	0.40	22.62
IVNS1ABP	-0.0005184	12106	GTEx	DepMap	Descartes	1.39	91.63
JAG1	-0.0005845	12282	GTEx	DepMap	Descartes	0.76	27.60
RHOB	-0.0006418	12378	GTEx	DepMap	Descartes	2.18	204.31
MARCKSL1	-0.0008080	12493	GTEx	DepMap	Descartes	0.86	121.47
HES1	-0.0009271	12523	GTEx	DepMap	Descartes	2.46	358.41

Noninflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.26e-01
Mean rank of genes in gene set: 9976.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAF	-0.0002552	9387	GTEx	DepMap	Descartes	0.80	24.89
CD163	-0.0003200	10566	GTEx	DepMap	Descartes	0.16	3.52

Meta_8 undefined undifferentiated neuronal (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.27e-01
Mean rank of genes in gene set: 10002
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTNNB1	-0.0001841	7685	GTEx	DepMap	Descartes	2.02	97.77
SOX11	-0.0006056	12319	GTEx	DepMap	Descartes	0.05	1.12

Cytotoxic T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.36e-01
Mean rank of genes in gene set: 11798
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85

Kidney Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.47e-01
Mean rank of genes in gene set: 12140
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LYPD1	-0.0005276	12140	GTEx	DepMap	Descartes	0.07	2.53

Adrenergic neuroblatoma (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - neuroblastoma adrenergic markers derived from their data, which are state as resembling sympathoblasts and lacking chromffin markers such as PNMT:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.48e-01
Mean rank of genes in gene set: 12150
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	-0.0005305	12150	GTEx	DepMap	Descartes	0.07	5.76

Adrenergic immature (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These is a marker listed for the immature adrenergic cells. SOX11 is referenced as important in early phases of pro-adrenergic differentiation (cites PMID 20147379) whereas SOX4 appears later. SOX11 is also associated with poor outcome in neuroblatoma bulk RNA-seq data (Olsen analysis).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.52e-01
Mean rank of genes in gene set: 12319
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOX11	-0.0006056	12319	GTEx	DepMap	Descartes	0.05	1.12

Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 9783.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NPY	-0.0000904	5103	GTEx	DepMap	Descartes	0.35	254.85
BCL2	-0.0005168	12098	GTEx	DepMap	Descartes	0.31	8.70
GAP43	-0.0005305	12150	GTEx	DepMap	Descartes	0.07	5.76

Proteasomal degradation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this is for proteasomal degradataion:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.56e-01
Mean rank of genes in gene set: 9040.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PSMA3	-0.0000366	3808	GTEx	DepMap	Descartes	0.96	170.19
PSMB3	-0.0002365	8979	GTEx	DepMap	Descartes	0.51	164.96
PSMC2	-0.0002769	9846	GTEx	DepMap	Descartes	0.53	38.04
PSMA4	-0.0003649	11124	GTEx	DepMap	Descartes	0.50	25.21
PSME2	-0.0003985	11447	GTEx	DepMap	Descartes	0.78	64.74

Leukocyte (Kildisiute)
Leukocyes markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 12505
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.0008493	12505	GTEx	DepMap	Descartes	0.15	5.98

Schwann cell precursor Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454). These genes were used to show cells transitioning from a SCP to a symphathoblast state in their human fetal single-cell RNA-seq data.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.62e-01
Mean rank of genes in gene set: 8305.9
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MOXD1	0.0018992	124	GTEx	DepMap	Descartes	0.96	66.64
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
COL2A1	-0.0001428	6552	GTEx	DepMap	Descartes	0.00	0.14
MBP	-0.0001799	7589	GTEx	DepMap	Descartes	0.41	10.31
POSTN	-0.0002268	8756	GTEx	DepMap	Descartes	5.53	312.48
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
S100B	-0.0003082	10393	GTEx	DepMap	Descartes	0.51	49.88
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76
GAS7	-0.0004778	11925	GTEx	DepMap	Descartes	0.96	24.80
NGFR	-0.0005475	12200	GTEx	DepMap	Descartes	1.57	112.99

Sympathobasts or chromaffin (Kildisiute)
Sympathoblast and chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.64e-01
Mean rank of genes in gene set: 10039.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34
CHGB	-0.0003637	11112	GTEx	DepMap	Descartes	0.15	13.25

Schwann cell precursor (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being characteristic of Schwann cell lineage and Furlan et al. (Science 2017, PMID 28684471) is referenced to support this. These cell types seem to be claimed to form a bridge between the mesenchymal and adrenergic cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.64e-01
Mean rank of genes in gene set: 10043.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
S100B	-0.0003082	10393	GTEx	DepMap	Descartes	0.51	49.88
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76

Schwann cell precursor-like Fig 1D (Olsen)
Similar to above, but for selected SCP marker genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.64e-01
Mean rank of genes in gene set: 10043.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
S100B	-0.0003082	10393	GTEx	DepMap	Descartes	0.51	49.88
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76

Chromaffin and connecting progenitor cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-01
Mean rank of genes in gene set: 9576
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DDC	-0.0002585	9457	GTEx	DepMap	Descartes	0.01	1.15
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34

Late chromaffin cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: this late chromaffin cell signature also includes PNMT, which is an enzyme catalyzing methylation of norepinephrine to form epinephrine; this marker is absent from the ealier less differentiated chromaffin cells (which may have been referred to as sympathoblasts in other datasets, I think):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-01
Mean rank of genes in gene set: 9576
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DDC	-0.0002585	9457	GTEx	DepMap	Descartes	0.01	1.15
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34

Bridge region SCP-adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP-adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.70e-01
Mean rank of genes in gene set: 9682
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PCBP2	-0.0001919	7874	GTEx	DepMap	Descartes	3.80	270.62
MDK	-0.0002182	8564	GTEx	DepMap	Descartes	2.24	367.79
SRP14	-0.0003168	10523	GTEx	DepMap	Descartes	2.74	533.84
HMGB1	-0.0004469	11767	GTEx	DepMap	Descartes	2.44	97.15

Chromaffin Cells (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: the neuronal markers NPY, PRPH, NTRK1 and ISL1 are used to annotate chromaffin cells; these were clearly expressed in neuroblasts in our analyses.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.72e-01
Mean rank of genes in gene set: 10255.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0001720	7378	GTEx	DepMap	Descartes	0.01	0.44
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
PHOX2A	-0.0004399	11730	GTEx	DepMap	Descartes	0.00	0.51

Neuroblastoma SCPs but not normal SCPs (Olsen)
The same as above:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.72e-01
Mean rank of genes in gene set: 11154
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB8	-0.0003406	10817	GTEx	DepMap	Descartes	0.27	4.43
GFRA3	-0.0004039	11491	GTEx	DepMap	Descartes	0.10	5.58

Neuroblastoma (Kildisiute)
Neuroblastoma markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 11215.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYCN	-0.0003315	10701	GTEx	DepMap	Descartes	0.05	2.72
PHOX2A	-0.0004399	11730	GTEx	DepMap	Descartes	0.00	0.51

HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 10395.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS10	-0.0002403	9069	GTEx	DepMap	Descartes	0.26	59.07
CD163	-0.0003200	10566	GTEx	DepMap	Descartes	0.16	3.52
AIF1	-0.0004111	11551	GTEx	DepMap	Descartes	0.03	4.21

Endothelial cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRB+ Endothelial cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.78e-01
Mean rank of genes in gene set: 10471
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EGFL7	-0.0002537	9359	GTEx	DepMap	Descartes	0.07	5.12
PTPRB	-0.0002905	10101	GTEx	DepMap	Descartes	0.28	3.05
FLT1	-0.0004839	11953	GTEx	DepMap	Descartes	0.26	5.20

Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 10154.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
UBE2C	-0.0002754	9812	GTEx	DepMap	Descartes	0.01	2.89
CDK1	-0.0003112	10436	GTEx	DepMap	Descartes	0.01	0.54
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Cell cycle (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.85e-01
Mean rank of genes in gene set: 10808.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47
PCNA	-0.0005072	12057	GTEx	DepMap	Descartes	0.23	33.44

Immune (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Immune cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 11998.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TMSB4X	-0.0004192	11603	GTEx	DepMap	Descartes	20.39	2597.82
LCP2	-0.0006544	12394	GTEx	DepMap	Descartes	0.16	6.75

N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 8347.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCL14	0.0002362	1455	GTEx	DepMap	Descartes	5.67	647.90
CACNA2D1	0.0000738	2337	GTEx	DepMap	Descartes	0.43	14.36
LGR5	-0.0000299	3668	GTEx	DepMap	Descartes	0.00	0.11
SCG5	-0.0000348	3759	GTEx	DepMap	Descartes	0.31	45.68
PPFIA2	-0.0001088	5627	GTEx	DepMap	Descartes	0.05	2.65
SYN2	-0.0002113	8397	GTEx	DepMap	Descartes	0.01	0.36
NAP1L5	-0.0002166	8518	GTEx	DepMap	Descartes	0.08	9.07
SLCO3A1	-0.0002808	9911	GTEx	DepMap	Descartes	0.61	26.36
ADCYAP1R1	-0.0002836	9968	GTEx	DepMap	Descartes	0.01	0.36
PTPRN	-0.0002865	10030	GTEx	DepMap	Descartes	0.03	1.53
PCLO	-0.0003796	11264	GTEx	DepMap	Descartes	0.02	0.26
SNAP25	-0.0003836	11303	GTEx	DepMap	Descartes	0.03	4.23
SCG3	-0.0004090	11533	GTEx	DepMap	Descartes	0.01	0.66
C1QL1	-0.0004243	11642	GTEx	DepMap	Descartes	0.02	2.73
CELF4	-0.0004743	11908	GTEx	DepMap	Descartes	0.03	1.84
GNAS	-0.0005657	12240	GTEx	DepMap	Descartes	20.40	1048.06

Meta_9 ATRX (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12190.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZFHX3	-0.0005172	12102	GTEx	DepMap	Descartes	1.66	19.31
ATRX	-0.0005832	12279	GTEx	DepMap	Descartes	2.20	44.52

Immune cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRC+ Immune cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12204
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD247	-0.0004734	11903	GTEx	DepMap	Descartes	0.01	0.60
PTPRC	-0.0008493	12505	GTEx	DepMap	Descartes	0.15	5.98

Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 11139.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRB	-0.0002905	10101	GTEx	DepMap	Descartes	0.28	3.05
KDR	-0.0004031	11484	GTEx	DepMap	Descartes	0.04	0.69
PLVAP	-0.0004609	11834	GTEx	DepMap	Descartes	0.36	20.94

Chromaffin cell development (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12238
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HAND2	-0.0005031	12034	GTEx	DepMap	Descartes	0.06	3.34
GATA3	-0.0007107	12442	GTEx	DepMap	Descartes	0.05	2.93

M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 8819.18
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL33	0.0012605	261	GTEx	DepMap	Descartes	1.02	87.17
CCL2	0.0002813	1300	GTEx	DepMap	Descartes	30.34	8049.66
CD80	-0.0002079	8306	GTEx	DepMap	Descartes	0.01	0.69
TLR4	-0.0002244	8699	GTEx	DepMap	Descartes	0.10	1.20
CD14	-0.0002500	9269	GTEx	DepMap	Descartes	0.31	37.41
IL18	-0.0003258	10623	GTEx	DepMap	Descartes	0.06	4.03
CXCL16	-0.0003418	10834	GTEx	DepMap	Descartes	0.33	30.30
ITGAX	-0.0003909	11393	GTEx	DepMap	Descartes	0.06	3.13
TNF	-0.0004401	11732	GTEx	DepMap	Descartes	0.07	6.22
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16
IL1B	-0.0005948	12309	GTEx	DepMap	Descartes	0.33	59.46

Meta5 unclear (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 12353
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98
STMN1	-0.0008845	12516	GTEx	DepMap	Descartes	0.44	30.86

Immune cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12502
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR4	-0.0008307	12499	GTEx	DepMap	Descartes	0.39	36.33
PTPRC	-0.0008493	12505	GTEx	DepMap	Descartes	0.15	5.98

Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.94e-01
Mean rank of genes in gene set: 9702
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SYN3	-0.0001610	7060	GTEx	DepMap	Descartes	0.00	0.03
ALK	-0.0001676	7250	GTEx	DepMap	Descartes	0.00	0.05
NEFM	-0.0002094	8349	GTEx	DepMap	Descartes	0.10	6.43
IL7	-0.0002492	9256	GTEx	DepMap	Descartes	0.02	1.53
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
GAP43	-0.0005305	12150	GTEx	DepMap	Descartes	0.07	5.76
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98

Late Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: the Jansky Late Neuroblast signature is the same as the earlier Neuroblast signature, but NEFM and ALK are now absent (meaning lower expressed at later stages of differentiation):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 10463
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SYN3	-0.0001610	7060	GTEx	DepMap	Descartes	0.00	0.03
IL7	-0.0002492	9256	GTEx	DepMap	Descartes	0.02	1.53
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
GAP43	-0.0005305	12150	GTEx	DepMap	Descartes	0.07	5.76
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98

IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 10838.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ISG15	-0.0002884	10061	GTEx	DepMap	Descartes	0.78	292.24
IFIT3	-0.0003117	10444	GTEx	DepMap	Descartes	0.32	35.65
IFIT2	-0.0003130	10464	GTEx	DepMap	Descartes	0.07	3.91
IFIT1	-0.0003839	11311	GTEx	DepMap	Descartes	0.17	7.94
ISG20	-0.0004754	11912	GTEx	DepMap	Descartes	0.10	4.27

Bridge region adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12239.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MLLT11	-0.0004923	11990	GTEx	DepMap	Descartes	0.33	31.23
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98
RGS5	-0.0011002	12538	GTEx	DepMap	Descartes	4.51	143.66

Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 9677.91
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAP1B	0.0008343	462	GTEx	DepMap	Descartes	10.96	209.32
NRG1	0.0000766	2311	GTEx	DepMap	Descartes	0.13	2.31
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
UCHL1	-0.0004853	11958	GTEx	DepMap	Descartes	0.70	92.25
MLLT11	-0.0004923	11990	GTEx	DepMap	Descartes	0.33	31.23
ELAVL4	-0.0005359	12169	GTEx	DepMap	Descartes	0.02	1.06
RTN1	-0.0005366	12174	GTEx	DepMap	Descartes	0.06	5.07
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98
RGS5	-0.0011002	12538	GTEx	DepMap	Descartes	4.51	143.66

Symphathoblasts (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. Several of these markers are also (more weakly) expressed in chromaffin cells. The authors data suggest Symphthoblasts give rise to chromaffin cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12062.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
ELAVL4	-0.0005359	12169	GTEx	DepMap	Descartes	0.02	1.06
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98
ELAVL3	-0.0005605	12233	GTEx	DepMap	Descartes	0.10	5.23

Broad sympathetic marker (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 11019.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34
CHGB	-0.0003637	11112	GTEx	DepMap	Descartes	0.15	13.25
GATA2	-0.0004072	11523	GTEx	DepMap	Descartes	0.12	5.31
HAND2	-0.0005031	12034	GTEx	DepMap	Descartes	0.06	3.34
GATA3	-0.0007107	12442	GTEx	DepMap	Descartes	0.05	2.93

Other T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11271.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-0.0001557	6915	GTEx	DepMap	Descartes	0.01	1.52
CCR7	-0.0004620	11844	GTEx	DepMap	Descartes	0.10	10.28
LEF1	-0.0005226	12126	GTEx	DepMap	Descartes	0.17	7.33
TCF7	-0.0005584	12231	GTEx	DepMap	Descartes	0.08	3.14
SELL	-0.0005626	12237	GTEx	DepMap	Descartes	0.09	8.45
CD4	-0.0005803	12274	GTEx	DepMap	Descartes	0.15	8.00

Symphathoblasts Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for symphathoblasts (differentiating from SCPs):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11821.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ELAVL2	-0.0003606	11057	GTEx	DepMap	Descartes	0.01	0.57
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
HAND2	-0.0005031	12034	GTEx	DepMap	Descartes	0.06	3.34
ELAVL4	-0.0005359	12169	GTEx	DepMap	Descartes	0.02	1.06
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98

Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9844
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAP1B	0.0008343	462	GTEx	DepMap	Descartes	10.96	209.32
DISP2	-0.0001232	6015	GTEx	DepMap	Descartes	0.04	0.83
SLC18A1	-0.0001836	7670	GTEx	DepMap	Descartes	0.01	0.89
TH	-0.0002187	8576	GTEx	DepMap	Descartes	0.11	17.74
DDC	-0.0002585	9457	GTEx	DepMap	Descartes	0.01	1.15
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88
DBH	-0.0003108	10430	GTEx	DepMap	Descartes	0.04	3.34
CYB561	-0.0003445	10884	GTEx	DepMap	Descartes	0.21	16.21
EML5	-0.0003445	10885	GTEx	DepMap	Descartes	0.02	0.82
CHGB	-0.0003637	11112	GTEx	DepMap	Descartes	0.15	13.25
PHOX2A	-0.0004399	11730	GTEx	DepMap	Descartes	0.00	0.51
UCHL1	-0.0004853	11958	GTEx	DepMap	Descartes	0.70	92.25
NNAT	-0.0004957	12000	GTEx	DepMap	Descartes	0.05	6.95
PCSK1N	-0.0004967	12008	GTEx	DepMap	Descartes	0.15	30.06
HAND2	-0.0005031	12034	GTEx	DepMap	Descartes	0.06	3.34
GATA3	-0.0007107	12442	GTEx	DepMap	Descartes	0.05	2.93

Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10704.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BASP1	0.0001956	1612	GTEx	DepMap	Descartes	3.41	418.50
NEFM	-0.0002094	8349	GTEx	DepMap	Descartes	0.10	6.43
NEFL	-0.0003184	10548	GTEx	DepMap	Descartes	0.01	0.24
ISL1	-0.0004264	11659	GTEx	DepMap	Descartes	0.04	4.35
CCND1	-0.0004802	11935	GTEx	DepMap	Descartes	1.07	47.98
ELAVL4	-0.0005359	12169	GTEx	DepMap	Descartes	0.02	1.06
RTN1	-0.0005366	12174	GTEx	DepMap	Descartes	0.06	5.07
STMN2	-0.0005432	12190	GTEx	DepMap	Descartes	0.14	14.98
ELAVL3	-0.0005605	12233	GTEx	DepMap	Descartes	0.10	5.23
INA	-0.0006340	12363	GTEx	DepMap	Descartes	0.07	3.66
STMN1	-0.0008845	12516	GTEx	DepMap	Descartes	0.44	30.86

Plasmacytoid dendritic cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Adrenal Cortex (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Symphatoblasts (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: Sympathoblasts were identified by Dong et al.28 based on the expression of CARTPT and INSM1, which we found expressed in chromaffin cells:
Autonomic neurons mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Erythroblast (Kildisiute)
Erythroblast markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Chromaffin (Kildisiute)
Chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Cortex (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for their broad Cortex group, which is composed of Fetal Zone, Definitive Zone and Adr Primordium subclusters:
Adrenal cortical (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that CYP11A1+ Adrenal cortical cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:

Below shows ranks on this GEP for literature curated gene lists for large gene sets
These include those reported as mesenchymal/adrenergic by Van Groningen et al.
High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8667.87
Median rank of genes in gene set: 9809
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
DPYSL3	0.0016161	171	GTEx	DepMap	Descartes	2.64	106.00
HMGA1	0.0013486	237	GTEx	DepMap	Descartes	2.12	228.28
NFIL3	0.0012540	264	GTEx	DepMap	Descartes	3.06	308.68
FOXO3	0.0012019	274	GTEx	DepMap	Descartes	4.48	141.31
AKAP12	0.0011439	297	GTEx	DepMap	Descartes	4.74	129.15
ANK2	0.0009678	370	GTEx	DepMap	Descartes	1.37	22.94
CDC42EP3	0.0009074	403	GTEx	DepMap	Descartes	2.50	103.11
RAB33A	0.0008897	420	GTEx	DepMap	Descartes	0.29	67.13
MAP1B	0.0008343	462	GTEx	DepMap	Descartes	10.96	209.32
SLIT3	0.0008138	483	GTEx	DepMap	Descartes	4.01	91.73
EIF1B	0.0007174	556	GTEx	DepMap	Descartes	2.33	542.29
HK2	0.0005431	754	GTEx	DepMap	Descartes	0.47	24.74
NCS1	0.0005168	801	GTEx	DepMap	Descartes	0.66	31.48
ATP6V1B2	0.0004447	926	GTEx	DepMap	Descartes	3.17	89.38
SETD7	0.0003868	1033	GTEx	DepMap	Descartes	0.88	26.69
CKB	0.0003299	1172	GTEx	DepMap	Descartes	1.31	259.43
PTS	0.0003130	1227	GTEx	DepMap	Descartes	0.48	104.47
SLC35G2	0.0002670	1336	GTEx	DepMap	Descartes	0.22	NA
TUBB4B	0.0002643	1343	GTEx	DepMap	Descartes	3.24	386.01
SHC3	0.0002527	1390	GTEx	DepMap	Descartes	0.06	1.12
PBX3	0.0002238	1498	GTEx	DepMap	Descartes	0.61	41.40
KLF13	0.0002036	1579	GTEx	DepMap	Descartes	1.80	60.64
HNRNPA0	0.0001433	1858	GTEx	DepMap	Descartes	2.46	65.85
GAL	0.0001388	1891	GTEx	DepMap	Descartes	0.30	167.09
CD200	0.0001263	1959	GTEx	DepMap	Descartes	0.57	48.91
TMEM108	0.0001027	2121	GTEx	DepMap	Descartes	0.06	2.54
LMO3	0.0000938	2182	GTEx	DepMap	Descartes	0.04	2.18
PHPT1	0.0000870	2240	GTEx	DepMap	Descartes	0.52	82.92
RTN2	0.0000845	2259	GTEx	DepMap	Descartes	0.08	8.13
GGCT	0.0000712	2353	GTEx	DepMap	Descartes	0.29	64.29

VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.23e-33
Mean rank of genes in gene set: 4221.95
Median rank of genes in gene set: 2153
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CCDC80	0.0069867	1	GTEx	DepMap	Descartes	33.69	633.28
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
MGP	0.0044677	13	GTEx	DepMap	Descartes	85.27	13772.01
AEBP1	0.0044091	15	GTEx	DepMap	Descartes	16.00	903.07
SPARC	0.0043564	16	GTEx	DepMap	Descartes	97.15	5083.02
MMP2	0.0042331	17	GTEx	DepMap	Descartes	9.61	638.66
HTRA1	0.0041513	19	GTEx	DepMap	Descartes	5.77	556.98
PLXDC2	0.0033209	30	GTEx	DepMap	Descartes	4.28	75.65
BGN	0.0030837	32	GTEx	DepMap	Descartes	26.43	2394.09
ANTXR1	0.0030827	33	GTEx	DepMap	Descartes	4.00	134.04
ERRFI1	0.0030548	35	GTEx	DepMap	Descartes	8.35	627.77
SLC39A14	0.0029184	38	GTEx	DepMap	Descartes	4.06	223.46
MRC2	0.0027418	51	GTEx	DepMap	Descartes	2.55	105.53
SERPINE2	0.0026950	53	GTEx	DepMap	Descartes	3.73	124.63
COL6A3	0.0026861	54	GTEx	DepMap	Descartes	13.50	294.90
COL5A1	0.0026552	57	GTEx	DepMap	Descartes	9.15	230.59
FBN1	0.0025472	61	GTEx	DepMap	Descartes	5.38	97.78
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80
TNFRSF12A	0.0024891	70	GTEx	DepMap	Descartes	4.53	591.45
LMNA	0.0023771	77	GTEx	DepMap	Descartes	19.16	1611.73
PXDC1	0.0023598	78	GTEx	DepMap	Descartes	3.48	407.76
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
TPBG	0.0022257	90	GTEx	DepMap	Descartes	1.80	63.24
FGFR1	0.0021877	94	GTEx	DepMap	Descartes	10.58	430.78
COL6A2	0.0021021	101	GTEx	DepMap	Descartes	14.61	1027.76
FSTL1	0.0020865	104	GTEx	DepMap	Descartes	9.63	353.78
UGDH	0.0020292	110	GTEx	DepMap	Descartes	4.87	487.94
MYADM	0.0018590	131	GTEx	DepMap	Descartes	12.23	1022.67
PALLD	0.0018155	139	GTEx	DepMap	Descartes	4.66	176.04
COL5A2	0.0018081	141	GTEx	DepMap	Descartes	6.16	168.95

Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.35e-01
Mean rank of genes in gene set: 6863.22
Median rank of genes in gene set: 7147
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
PAPSS2	0.0012356	268	GTEx	DepMap	Descartes	1.05	65.30
SH3PXD2B	0.0011314	302	GTEx	DepMap	Descartes	0.69	22.06
CLU	0.0004464	922	GTEx	DepMap	Descartes	3.75	337.94
IGF1R	0.0001835	1661	GTEx	DepMap	Descartes	0.71	13.87
SLC16A9	0.0001441	1853	GTEx	DepMap	Descartes	0.07	3.64
LDLR	0.0000750	2325	GTEx	DepMap	Descartes	1.90	83.88
ERN1	0.0000459	2561	GTEx	DepMap	Descartes	0.66	19.32
SH3BP5	0.0000431	2593	GTEx	DepMap	Descartes	1.35	78.47
SCAP	0.0000000	3138	GTEx	DepMap	Descartes	0.23	12.04
STAR	-0.0000465	4014	GTEx	DepMap	Descartes	0.03	2.32
FDXR	-0.0000679	4546	GTEx	DepMap	Descartes	0.04	3.67
GSTA4	-0.0000887	5069	GTEx	DepMap	Descartes	0.29	31.97
BAIAP2L1	-0.0000889	5072	GTEx	DepMap	Descartes	0.01	0.79
FDX1	-0.0000944	5200	GTEx	DepMap	Descartes	0.28	21.57
INHA	-0.0001026	5434	GTEx	DepMap	Descartes	0.00	0.00
SGCZ	-0.0001037	5470	GTEx	DepMap	Descartes	0.00	0.00
DHCR7	-0.0001072	5584	GTEx	DepMap	Descartes	0.07	6.98
FREM2	-0.0001484	6724	GTEx	DepMap	Descartes	0.00	0.00
POR	-0.0001793	7570	GTEx	DepMap	Descartes	0.54	50.72
DNER	-0.0001849	7702	GTEx	DepMap	Descartes	0.05	1.99
FRMD5	-0.0001969	8003	GTEx	DepMap	Descartes	0.03	1.01
TM7SF2	-0.0001977	8024	GTEx	DepMap	Descartes	0.02	1.65
SCARB1	-0.0002184	8571	GTEx	DepMap	Descartes	0.15	5.61
NPC1	-0.0002346	8944	GTEx	DepMap	Descartes	0.34	14.33
APOC1	-0.0002645	9587	GTEx	DepMap	Descartes	0.36	112.09
DHCR24	-0.0002761	9830	GTEx	DepMap	Descartes	0.13	4.35
GRAMD1B	-0.0003542	10987	GTEx	DepMap	Descartes	0.05	1.40
PDE10A	-0.0003564	11011	GTEx	DepMap	Descartes	0.13	2.68
JAKMIP2	-0.0003718	11180	GTEx	DepMap	Descartes	0.00	0.08
SLC1A2	-0.0003895	11377	GTEx	DepMap	Descartes	0.02	0.35

Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7899.27
Median rank of genes in gene set: 8159
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
GREM1	0.0026166	59	GTEx	DepMap	Descartes	3.34	43.77
MAP1B	0.0008343	462	GTEx	DepMap	Descartes	10.96	209.32
BASP1	0.0001956	1612	GTEx	DepMap	Descartes	3.41	418.50
CNTFR	0.0001584	1768	GTEx	DepMap	Descartes	0.09	9.30
GAL	0.0001388	1891	GTEx	DepMap	Descartes	0.30	167.09
RGMB	0.0000669	2392	GTEx	DepMap	Descartes	0.57	25.39
EYA4	-0.0000005	3145	GTEx	DepMap	Descartes	0.02	1.43
TUBB2A	-0.0000312	3691	GTEx	DepMap	Descartes	1.81	249.20
NPY	-0.0000904	5103	GTEx	DepMap	Descartes	0.35	254.85
EPHA6	-0.0000973	5283	GTEx	DepMap	Descartes	0.01	0.40
KCNB2	-0.0001215	5962	GTEx	DepMap	Descartes	0.00	0.12
TMEFF2	-0.0001427	6550	GTEx	DepMap	Descartes	0.01	0.78
ANKFN1	-0.0001454	6628	GTEx	DepMap	Descartes	0.00	0.00
PLXNA4	-0.0001545	6886	GTEx	DepMap	Descartes	0.03	0.87
SLC44A5	-0.0001571	6954	GTEx	DepMap	Descartes	0.00	0.12
ALK	-0.0001676	7250	GTEx	DepMap	Descartes	0.00	0.05
RPH3A	-0.0001686	7277	GTEx	DepMap	Descartes	0.01	0.17
TMEM132C	-0.0001701	7322	GTEx	DepMap	Descartes	0.03	1.64
NTRK1	-0.0001720	7378	GTEx	DepMap	Descartes	0.01	0.44
EYA1	-0.0001956	7968	GTEx	DepMap	Descartes	0.01	0.26
FAT3	-0.0002026	8159	GTEx	DepMap	Descartes	0.07	0.95
RBFOX1	-0.0002111	8392	GTEx	DepMap	Descartes	0.01	0.86
HS3ST5	-0.0002275	8771	GTEx	DepMap	Descartes	0.00	0.14
IL7	-0.0002492	9256	GTEx	DepMap	Descartes	0.02	1.53
SLC6A2	-0.0002856	10011	GTEx	DepMap	Descartes	0.01	0.36
RYR2	-0.0002931	10155	GTEx	DepMap	Descartes	0.03	0.50
PTCHD1	-0.0002986	10251	GTEx	DepMap	Descartes	0.01	0.39
CNKSR2	-0.0003293	10672	GTEx	DepMap	Descartes	0.04	1.45
MARCH11	-0.0003315	10700	GTEx	DepMap	Descartes	0.00	NA
MAB21L2	-0.0003605	11056	GTEx	DepMap	Descartes	0.03	1.22

Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8924.5
Median rank of genes in gene set: 10213
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
TMEM88	0.0013292	242	GTEx	DepMap	Descartes	0.74	214.75
NPR1	0.0006164	657	GTEx	DepMap	Descartes	0.15	7.13
SHE	0.0001629	1753	GTEx	DepMap	Descartes	0.17	5.73
GALNT15	-0.0000134	3350	GTEx	DepMap	Descartes	0.09	NA
CHRM3	-0.0000644	4458	GTEx	DepMap	Descartes	0.03	0.94
CRHBP	-0.0000879	5050	GTEx	DepMap	Descartes	0.00	0.00
RASIP1	-0.0001141	5768	GTEx	DepMap	Descartes	0.09	5.09
NR5A2	-0.0001244	6050	GTEx	DepMap	Descartes	0.00	0.21
CEACAM1	-0.0001423	6537	GTEx	DepMap	Descartes	0.03	2.31
MYRIP	-0.0001587	6997	GTEx	DepMap	Descartes	0.01	0.33
EHD3	-0.0001860	7733	GTEx	DepMap	Descartes	0.10	4.24
F8	-0.0001878	7776	GTEx	DepMap	Descartes	0.08	1.34
ESM1	-0.0001961	7979	GTEx	DepMap	Descartes	0.14	7.76
IRX3	-0.0002470	9217	GTEx	DepMap	Descartes	0.09	4.44
CDH13	-0.0002496	9268	GTEx	DepMap	Descartes	0.26	7.67
BTNL9	-0.0002646	9590	GTEx	DepMap	Descartes	0.00	0.15
HYAL2	-0.0002845	9990	GTEx	DepMap	Descartes	0.14	6.29
SLCO2A1	-0.0002891	10077	GTEx	DepMap	Descartes	0.14	5.11
PTPRB	-0.0002905	10101	GTEx	DepMap	Descartes	0.28	3.05
TEK	-0.0003036	10325	GTEx	DepMap	Descartes	0.06	1.78
ROBO4	-0.0003094	10414	GTEx	DepMap	Descartes	0.08	3.40
CLDN5	-0.0003148	10487	GTEx	DepMap	Descartes	0.02	1.84
KANK3	-0.0003205	10572	GTEx	DepMap	Descartes	0.03	1.84
CALCRL	-0.0003455	10899	GTEx	DepMap	Descartes	0.37	8.56
FLT4	-0.0003470	10913	GTEx	DepMap	Descartes	0.03	0.77
NOTCH4	-0.0003737	11201	GTEx	DepMap	Descartes	0.07	1.98
CDH5	-0.0003821	11284	GTEx	DepMap	Descartes	0.09	3.25
TIE1	-0.0003859	11337	GTEx	DepMap	Descartes	0.17	6.31
MMRN2	-0.0003889	11371	GTEx	DepMap	Descartes	0.10	2.54
KDR	-0.0004031	11484	GTEx	DepMap	Descartes	0.04	0.69

Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.03e-13
Mean rank of genes in gene set: 2432.09
Median rank of genes in gene set: 327
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CCDC80	0.0069867	1	GTEx	DepMap	Descartes	33.69	633.28
ELN	0.0058802	3	GTEx	DepMap	Descartes	7.57	418.48
SFRP2	0.0054421	8	GTEx	DepMap	Descartes	15.81	1250.54
C7	0.0049521	9	GTEx	DepMap	Descartes	33.04	1506.66
COL3A1	0.0047243	11	GTEx	DepMap	Descartes	126.13	4329.75
MGP	0.0044677	13	GTEx	DepMap	Descartes	85.27	13772.01
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
LOX	0.0028262	46	GTEx	DepMap	Descartes	2.26	99.28
COL6A3	0.0026861	54	GTEx	DepMap	Descartes	13.50	294.90
IGFBP3	0.0025256	64	GTEx	DepMap	Descartes	3.06	282.00
DCN	0.0025162	65	GTEx	DepMap	Descartes	52.47	1684.07
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
SCARA5	0.0019878	112	GTEx	DepMap	Descartes	1.42	78.71
ADAMTS2	0.0018095	140	GTEx	DepMap	Descartes	2.24	67.44
PCOLCE	0.0017289	145	GTEx	DepMap	Descartes	6.54	899.52
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.90
RSPO3	0.0015000	197	GTEx	DepMap	Descartes	0.33	NA
ITGA11	0.0013680	229	GTEx	DepMap	Descartes	0.86	17.18
ISLR	0.0013554	235	GTEx	DepMap	Descartes	4.09	391.40
COL12A1	0.0011701	284	GTEx	DepMap	Descartes	4.92	91.28
DKK2	0.0011280	306	GTEx	DepMap	Descartes	0.24	13.39
CDH11	0.0010023	348	GTEx	DepMap	Descartes	2.16	61.69
LUM	0.0009055	405	GTEx	DepMap	Descartes	27.51	1956.82
COL27A1	0.0009018	409	GTEx	DepMap	Descartes	0.98	33.29
OGN	0.0006488	622	GTEx	DepMap	Descartes	4.26	292.26
CD248	0.0005513	739	GTEx	DepMap	Descartes	0.73	58.64
BICC1	0.0004849	860	GTEx	DepMap	Descartes	1.00	39.38
GLI2	0.0004577	901	GTEx	DepMap	Descartes	0.26	9.65
CLDN11	0.0004107	992	GTEx	DepMap	Descartes	0.46	33.06

Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.20e-01
Mean rank of genes in gene set: 6304.97
Median rank of genes in gene set: 5396
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ARC	0.0016794	154	GTEx	DepMap	Descartes	3.21	309.46
FGF14	0.0007592	522	GTEx	DepMap	Descartes	0.14	2.77
MGAT4C	0.0001425	1866	GTEx	DepMap	Descartes	0.05	0.47
PENK	0.0001110	2054	GTEx	DepMap	Descartes	0.16	48.22
SLC24A2	0.0000186	2880	GTEx	DepMap	Descartes	0.00	0.10
KCTD16	0.0000035	3081	GTEx	DepMap	Descartes	0.05	0.63
EML6	-0.0000144	3370	GTEx	DepMap	Descartes	0.03	0.90
SPOCK3	-0.0000231	3539	GTEx	DepMap	Descartes	0.00	0.04
SLC35F3	-0.0000272	3613	GTEx	DepMap	Descartes	0.00	0.08
CDH18	-0.0000393	3861	GTEx	DepMap	Descartes	0.01	0.91
PACRG	-0.0000635	4430	GTEx	DepMap	Descartes	0.00	0.20
CDH12	-0.0000643	4449	GTEx	DepMap	Descartes	0.00	0.56
GALNTL6	-0.0000657	4485	GTEx	DepMap	Descartes	0.00	0.41
SORCS3	-0.0000662	4496	GTEx	DepMap	Descartes	0.00	0.40
GRM7	-0.0000680	4547	GTEx	DepMap	Descartes	0.01	0.87
AGBL4	-0.0000773	4777	GTEx	DepMap	Descartes	0.01	0.43
GCH1	-0.0000807	4861	GTEx	DepMap	Descartes	0.52	43.24
PCSK2	-0.0000811	4868	GTEx	DepMap	Descartes	0.04	2.23
TBX20	-0.0000973	5281	GTEx	DepMap	Descartes	0.00	0.00
ST18	-0.0001050	5511	GTEx	DepMap	Descartes	0.00	0.02
CCSER1	-0.0001181	5878	GTEx	DepMap	Descartes	0.00	NA
GRID2	-0.0001403	6480	GTEx	DepMap	Descartes	0.00	0.03
KSR2	-0.0001449	6614	GTEx	DepMap	Descartes	0.00	0.04
ROBO1	-0.0001642	7157	GTEx	DepMap	Descartes	0.30	8.88
LAMA3	-0.0001784	7550	GTEx	DepMap	Descartes	0.10	2.27
SLC18A1	-0.0001836	7670	GTEx	DepMap	Descartes	0.01	0.89
FAM155A	-0.0001879	7780	GTEx	DepMap	Descartes	0.12	2.66
NTNG1	-0.0002064	8263	GTEx	DepMap	Descartes	0.02	1.41
DGKK	-0.0002334	8912	GTEx	DepMap	Descartes	0.01	0.26
CHGA	-0.0002766	9841	GTEx	DepMap	Descartes	0.49	66.88

Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.37e-01
Mean rank of genes in gene set: 6936.14
Median rank of genes in gene set: 7411
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
MARCH3	0.0011923	275	GTEx	DepMap	Descartes	0.69	NA
MICAL2	0.0009807	361	GTEx	DepMap	Descartes	2.79	100.42
SELENBP1	0.0004672	887	GTEx	DepMap	Descartes	0.39	29.89
SLC25A37	0.0001434	1857	GTEx	DepMap	Descartes	1.01	56.07
BLVRB	0.0000955	2166	GTEx	DepMap	Descartes	0.29	48.38
SLC25A21	0.0000210	2847	GTEx	DepMap	Descartes	0.00	0.20
GCLC	0.0000025	3103	GTEx	DepMap	Descartes	0.34	23.04
RHD	-0.0000344	3755	GTEx	DepMap	Descartes	0.00	0.00
SLC4A1	-0.0000518	4151	GTEx	DepMap	Descartes	0.01	0.17
ALAS2	-0.0000771	4772	GTEx	DepMap	Descartes	0.00	0.00
DENND4A	-0.0000870	5029	GTEx	DepMap	Descartes	1.03	29.27
TMCC2	-0.0000943	5198	GTEx	DepMap	Descartes	0.02	1.01
TFR2	-0.0001219	5969	GTEx	DepMap	Descartes	0.00	0.35
ABCB10	-0.0001642	7156	GTEx	DepMap	Descartes	0.11	5.75
SPTB	-0.0001733	7411	GTEx	DepMap	Descartes	0.01	0.27
XPO7	-0.0002040	8198	GTEx	DepMap	Descartes	0.26	10.70
FECH	-0.0002291	8805	GTEx	DepMap	Descartes	0.06	1.32
TRAK2	-0.0002308	8844	GTEx	DepMap	Descartes	0.29	9.61
ANK1	-0.0002714	9720	GTEx	DepMap	Descartes	0.06	1.23
CAT	-0.0002717	9727	GTEx	DepMap	Descartes	0.35	40.11
CPOX	-0.0002968	10211	GTEx	DepMap	Descartes	0.06	4.49
SNCA	-0.0003051	10344	GTEx	DepMap	Descartes	0.03	1.46
SPECC1	-0.0003258	10625	GTEx	DepMap	Descartes	0.17	4.22
RAPGEF2	-0.0003453	10893	GTEx	DepMap	Descartes	0.87	21.91
GYPC	-0.0003623	11082	GTEx	DepMap	Descartes	0.53	75.43
RGS6	-0.0004435	11747	GTEx	DepMap	Descartes	0.02	0.77
EPB41	-0.0004697	11878	GTEx	DepMap	Descartes	0.03	0.92
TSPAN5	-0.0004743	11909	GTEx	DepMap	Descartes	0.41	23.36
SOX6	-0.0005574	12228	GTEx	DepMap	Descartes	0.10	2.52
NA	NA	NA	NA	NA	NA	NA	NA

Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 7291.05
Median rank of genes in gene set: 8451.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CST3	0.0016582	160	GTEx	DepMap	Descartes	15.01	1068.58
HRH1	0.0007300	546	GTEx	DepMap	Descartes	0.52	25.55
AXL	0.0005792	703	GTEx	DepMap	Descartes	1.96	89.76
ABCA1	0.0005093	815	GTEx	DepMap	Descartes	1.97	47.97
CTSC	0.0004799	868	GTEx	DepMap	Descartes	2.02	87.40
FGL2	0.0004096	995	GTEx	DepMap	Descartes	1.21	60.78
LGMN	0.0002146	1532	GTEx	DepMap	Descartes	1.53	147.29
CTSD	0.0002071	1561	GTEx	DepMap	Descartes	3.83	387.70
IFNGR1	0.0000058	3047	GTEx	DepMap	Descartes	0.65	57.94
SLC1A3	-0.0000361	3795	GTEx	DepMap	Descartes	0.16	7.88
ITPR2	-0.0000891	5077	GTEx	DepMap	Descartes	0.50	9.42
SLC9A9	-0.0000958	5240	GTEx	DepMap	Descartes	0.15	10.65
CPVL	-0.0000971	5276	GTEx	DepMap	Descartes	0.19	14.31
SPP1	-0.0001141	5767	GTEx	DepMap	Descartes	0.23	15.58
ATP8B4	-0.0001534	6861	GTEx	DepMap	Descartes	0.06	3.23
FGD2	-0.0001560	6924	GTEx	DepMap	Descartes	0.00	0.21
CD163L1	-0.0001571	6951	GTEx	DepMap	Descartes	0.00	0.00
RBPJ	-0.0001728	7396	GTEx	DepMap	Descartes	1.71	61.74
WWP1	-0.0001911	7851	GTEx	DepMap	Descartes	0.21	7.94
MS4A4A	-0.0002398	9052	GTEx	DepMap	Descartes	0.10	8.02
CD14	-0.0002500	9269	GTEx	DepMap	Descartes	0.31	37.41
MARCH1	-0.0002568	9428	GTEx	DepMap	Descartes	0.02	NA
ADAP2	-0.0002758	9816	GTEx	DepMap	Descartes	0.03	1.55
MERTK	-0.0002791	9884	GTEx	DepMap	Descartes	0.08	3.67
CTSB	-0.0002886	10063	GTEx	DepMap	Descartes	3.46	196.62
FMN1	-0.0003059	10356	GTEx	DepMap	Descartes	0.06	0.77
CD163	-0.0003200	10566	GTEx	DepMap	Descartes	0.16	3.52
MSR1	-0.0003224	10595	GTEx	DepMap	Descartes	0.07	3.08
CSF1R	-0.0003336	10730	GTEx	DepMap	Descartes	0.09	3.95
SFMBT2	-0.0003559	11004	GTEx	DepMap	Descartes	0.10	2.61

Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 7564.41
Median rank of genes in gene set: 9201.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
VCAN	0.0022721	85	GTEx	DepMap	Descartes	12.89	251.23
COL5A2	0.0018081	141	GTEx	DepMap	Descartes	6.16	168.95
SFRP1	0.0010606	327	GTEx	DepMap	Descartes	2.00	82.76
VIM	0.0008371	460	GTEx	DepMap	Descartes	50.48	4574.75
LAMC1	0.0004863	854	GTEx	DepMap	Descartes	4.41	120.83
DST	0.0004344	942	GTEx	DepMap	Descartes	4.30	48.45
ADAMTS5	0.0002047	1572	GTEx	DepMap	Descartes	0.31	6.81
PMP22	0.0001558	1779	GTEx	DepMap	Descartes	1.80	211.85
HMGA2	0.0001427	1862	GTEx	DepMap	Descartes	0.10	3.06
ERBB4	0.0001269	1953	GTEx	DepMap	Descartes	0.04	1.14
PLCE1	0.0001084	2072	GTEx	DepMap	Descartes	0.18	4.38
LAMA4	-0.0000879	5051	GTEx	DepMap	Descartes	2.32	64.38
FIGN	-0.0000894	5085	GTEx	DepMap	Descartes	0.17	3.43
LRRTM4	-0.0001037	5468	GTEx	DepMap	Descartes	0.01	0.55
IL1RAPL2	-0.0001039	5476	GTEx	DepMap	Descartes	0.00	0.00
MPZ	-0.0001147	5782	GTEx	DepMap	Descartes	0.06	3.32
EGFLAM	-0.0001233	6021	GTEx	DepMap	Descartes	0.38	17.39
TRPM3	-0.0001270	6124	GTEx	DepMap	Descartes	0.04	0.79
MDGA2	-0.0001332	6276	GTEx	DepMap	Descartes	0.00	0.12
COL25A1	-0.0001771	7518	GTEx	DepMap	Descartes	0.01	0.33
IL1RAPL1	-0.0001850	7705	GTEx	DepMap	Descartes	0.00	0.45
PLP1	-0.0002432	9133	GTEx	DepMap	Descartes	0.28	13.80
XKR4	-0.0002500	9270	GTEx	DepMap	Descartes	0.06	0.35
SOX5	-0.0002596	9475	GTEx	DepMap	Descartes	0.12	3.22
PTPRZ1	-0.0002897	10086	GTEx	DepMap	Descartes	0.09	1.29
NRXN3	-0.0002965	10204	GTEx	DepMap	Descartes	0.12	3.49
GRIK3	-0.0003073	10377	GTEx	DepMap	Descartes	0.05	0.58
ERBB3	-0.0003235	10605	GTEx	DepMap	Descartes	0.07	1.76
SLC35F1	-0.0003279	10651	GTEx	DepMap	Descartes	0.05	0.90
PPP2R2B	-0.0003846	11319	GTEx	DepMap	Descartes	0.04	0.66

Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.84e-01
Mean rank of genes in gene set: 5967.69
Median rank of genes in gene set: 5393
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
THBS1	0.0011814	280	GTEx	DepMap	Descartes	23.10	877.16
TPM4	0.0011588	292	GTEx	DepMap	Descartes	7.32	298.97
ACTN1	0.0010403	331	GTEx	DepMap	Descartes	6.49	343.72
VCL	0.0009725	366	GTEx	DepMap	Descartes	3.35	90.19
SLC24A3	0.0009637	374	GTEx	DepMap	Descartes	0.18	9.63
HIPK2	0.0008762	430	GTEx	DepMap	Descartes	2.25	33.61
MYLK	0.0008226	474	GTEx	DepMap	Descartes	3.28	68.00
GSN	0.0007021	567	GTEx	DepMap	Descartes	11.79	504.60
LIMS1	0.0006976	572	GTEx	DepMap	Descartes	3.29	158.03
LTBP1	0.0006382	636	GTEx	DepMap	Descartes	1.63	62.82
CD9	0.0005415	756	GTEx	DepMap	Descartes	1.96	227.52
ZYX	0.0004754	873	GTEx	DepMap	Descartes	3.78	357.27
PDE3A	0.0003081	1238	GTEx	DepMap	Descartes	0.76	21.42
UBASH3B	0.0002790	1306	GTEx	DepMap	Descartes	0.54	19.93
STON2	0.0002182	1522	GTEx	DepMap	Descartes	0.10	5.46
DOK6	0.0000179	2890	GTEx	DepMap	Descartes	0.11	2.61
TLN1	-0.0000025	3175	GTEx	DepMap	Descartes	3.24	86.21
MED12L	-0.0000075	3243	GTEx	DepMap	Descartes	0.05	1.12
ANGPT1	-0.0000293	3655	GTEx	DepMap	Descartes	0.23	12.16
TUBB1	-0.0000443	3967	GTEx	DepMap	Descartes	0.01	0.46
STOM	-0.0000664	4504	GTEx	DepMap	Descartes	3.33	237.51
ITGA2B	-0.0000819	4894	GTEx	DepMap	Descartes	0.02	0.83
ITGB3	-0.0001008	5393	GTEx	DepMap	Descartes	0.04	1.32
ARHGAP6	-0.0001505	6788	GTEx	DepMap	Descartes	0.09	3.71
GP1BA	-0.0001540	6883	GTEx	DepMap	Descartes	0.01	0.54
RAB27B	-0.0001649	7180	GTEx	DepMap	Descartes	0.01	0.15
P2RX1	-0.0001736	7423	GTEx	DepMap	Descartes	0.01	0.87
RAP1B	-0.0001950	7951	GTEx	DepMap	Descartes	1.07	18.52
TRPC6	-0.0001965	7988	GTEx	DepMap	Descartes	0.02	0.71
MMRN1	-0.0002293	8811	GTEx	DepMap	Descartes	0.08	1.79

Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10332.98
Median rank of genes in gene set: 11732
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ARID5B	0.0012195	271	GTEx	DepMap	Descartes	8.16	240.22
FOXP1	0.0006507	620	GTEx	DepMap	Descartes	4.26	113.52
CD44	0.0002845	1291	GTEx	DepMap	Descartes	6.80	316.02
ETS1	-0.0000613	4378	GTEx	DepMap	Descartes	3.35	137.37
NCALD	-0.0001657	7205	GTEx	DepMap	Descartes	0.32	20.66
ABLIM1	-0.0001751	7462	GTEx	DepMap	Descartes	0.79	24.24
MSN	-0.0002020	8145	GTEx	DepMap	Descartes	2.11	117.57
MCTP2	-0.0002224	8664	GTEx	DepMap	Descartes	0.02	0.99
SP100	-0.0002422	9106	GTEx	DepMap	Descartes	1.17	50.54
SAMD3	-0.0002559	9407	GTEx	DepMap	Descartes	0.00	0.00
BACH2	-0.0002659	9613	GTEx	DepMap	Descartes	0.28	6.77
SKAP1	-0.0002919	10134	GTEx	DepMap	Descartes	0.01	1.25
SCML4	-0.0003095	10416	GTEx	DepMap	Descartes	0.01	0.52
CELF2	-0.0003103	10424	GTEx	DepMap	Descartes	1.18	35.85
RCSD1	-0.0003493	10956	GTEx	DepMap	Descartes	0.07	2.62
TOX	-0.0003621	11078	GTEx	DepMap	Descartes	0.01	0.29
STK39	-0.0003809	11273	GTEx	DepMap	Descartes	0.15	8.58
CCND3	-0.0003833	11298	GTEx	DepMap	Descartes	0.23	20.90
RAP1GAP2	-0.0003959	11431	GTEx	DepMap	Descartes	0.04	1.26
DOCK10	-0.0004201	11606	GTEx	DepMap	Descartes	0.36	11.03
PITPNC1	-0.0004337	11694	GTEx	DepMap	Descartes	0.58	18.27
EVL	-0.0004471	11770	GTEx	DepMap	Descartes	0.70	41.62
ITPKB	-0.0004565	11808	GTEx	DepMap	Descartes	0.44	15.51
ARHGAP15	-0.0004742	11907	GTEx	DepMap	Descartes	0.13	9.77
ANKRD44	-0.0004796	11931	GTEx	DepMap	Descartes	0.10	2.82
BCL2	-0.0005168	12098	GTEx	DepMap	Descartes	0.31	8.70
PDE3B	-0.0005169	12099	GTEx	DepMap	Descartes	0.03	1.56
LEF1	-0.0005226	12126	GTEx	DepMap	Descartes	0.17	7.33
MBNL1	-0.0005445	12192	GTEx	DepMap	Descartes	2.28	76.64
PRKCH	-0.0005724	12254	GTEx	DepMap	Descartes	0.13	5.30

Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.51e-05
Mean rank of genes in gene set: 1656.44
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANGPTL1	0.0025162	66	GTEx	DepMap	Descartes	0.76	43.25
PRRX1	0.0022543	89	GTEx	DepMap	Descartes	3.73	219.98
PDGFRA	0.0015886	176	GTEx	DepMap	Descartes	2.11	77.90
F10	0.0011627	289	GTEx	DepMap	Descartes	0.26	39.42
SFRP1	0.0010606	327	GTEx	DepMap	Descartes	2.00	82.76
NTRK2	0.0009224	396	GTEx	DepMap	Descartes	1.41	37.05
OLFML1	0.0007673	516	GTEx	DepMap	Descartes	0.77	57.21
SMOC2	0.0007198	555	GTEx	DepMap	Descartes	2.55	151.65
EBF2	-0.0008115	12494	GTEx	DepMap	Descartes	0.39	14.42

Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.48e-03
Mean rank of genes in gene set: 58.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0028888	42	GTEx	DepMap	Descartes	100.15	3194.77
DCN	0.0025162	65	GTEx	DepMap	Descartes	52.47	1684.07
COL1A1	0.0024975	68	GTEx	DepMap	Descartes	246.05	7592.80

DC: Transitional DC (curated markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.19e-02
Mean rank of genes in gene set: 487.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLF4	0.0012087	272	GTEx	DepMap	Descartes	6.22	508.90
AXL	0.0005792	703	GTEx	DepMap	Descartes	1.96	89.76

Monocyte precursor: Monocyte precursor (curated markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.38e-02
Mean rank of genes in gene set: 85
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	0.0022721	85	GTEx	DepMap	Descartes	12.89	251.23

T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.42e-02
Mean rank of genes in gene set: 2381
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
INPP5J	0.0004185	971	GTEx	DepMap	Descartes	0.11	7.61
PANX2	-0.0000359	3791	GTEx	DepMap	Descartes	0.02	1.21

MNP: MNP (curated markers)
mononuclear phagocytes including dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.25e-02
Mean rank of genes in gene set: 995
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FGL2	0.0004096	995	GTEx	DepMap	Descartes	1.21	60.78

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.95e-02
Mean rank of genes in gene set: 1172
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CKB	0.0003299	1172	GTEx	DepMap	Descartes	1.31	259.43

Macrophages: Kupffer cells (curated markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.18e-02
Mean rank of genes in gene set: 2706.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAM1	0.0005638	726	GTEx	DepMap	Descartes	2.03	100.11
CD5L	-0.0000735	4687	GTEx	DepMap	Descartes	0.13	7.99

Plasma cells: Plasma cells (model markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.91e-02
Mean rank of genes in gene set: 3836.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
XBP1	0.0018846	128	GTEx	DepMap	Descartes	4.39	476.08
TGFBR3L	-0.0000502	4114	GTEx	DepMap	Descartes	0.00	NA
ST18	-0.0001050	5511	GTEx	DepMap	Descartes	0.00	0.02
MZB1	-0.0001076	5593	GTEx	DepMap	Descartes	0.01	NA

Plasma cells: Plasma cells (curated markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.13e-02
Mean rank of genes in gene set: 2860.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
XBP1	0.0018846	128	GTEx	DepMap	Descartes	4.39	476.08
MZB1	-0.0001076	5593	GTEx	DepMap	Descartes	0.01	NA

ILC precursor: ILC precursor (model markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-02
Mean rank of genes in gene set: 3591.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HUNK	0.0001996	1597	GTEx	DepMap	Descartes	0.09	2.15
PDZK1	-0.0000252	3574	GTEx	DepMap	Descartes	0.00	0.66
HPN	-0.0001080	5604	GTEx	DepMap	Descartes	0.00	0.00

ETP: ETP (curated markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.04e-01
Mean rank of genes in gene set: 3056.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	0.0001178	2013	GTEx	DepMap	Descartes	0.93	21.57
SPINK2	-0.0000498	4100	GTEx	DepMap	Descartes	0.00	0.00

HSC/MPP: HSC/MPP (curated markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.11e-01
Mean rank of genes in gene set: 3721
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	0.0001178	2013	GTEx	DepMap	Descartes	0.93	21.57
SPINK2	-0.0000498	4100	GTEx	DepMap	Descartes	0.00	0.00
CRHBP	-0.0000879	5050	GTEx	DepMap	Descartes	0.00	0.00

ETP: ETP (model markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.15e-01
Mean rank of genes in gene set: 3199.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	1.11e-04	2054	GTEx	DepMap	Descartes	0.16	48.22
WDR49	-6.02e-05	4345	GTEx	DepMap	Descartes	0.00	0.00

T cells: Memory CD4+ cytotoxic T cells (model markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.22e-01
Mean rank of genes in gene set: 2054
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.000111	2054	GTEx	DepMap	Descartes	0.16	48.22

ILC: ILC2 (model markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.26e-01
Mean rank of genes in gene set: 2126
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL17RB	0.0001014	2126	GTEx	DepMap	Descartes	0.03	2.77

Granulocytes: Neutrophils (curated markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.31e-01
Mean rank of genes in gene set: 2216
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCN2	9e-05	2216	GTEx	DepMap	Descartes	0	0

Epithelial cells: Epithelial cells (curated markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.38e-01
Mean rank of genes in gene set: 2324
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT17	7.51e-05	2324	GTEx	DepMap	Descartes	0.02	4.43

ILC: ILC (curated markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.41e-01
Mean rank of genes in gene set: 4020.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A13	0.0008576	442	GTEx	DepMap	Descartes	0.89	102.30
TLE1	0.0002344	1460	GTEx	DepMap	Descartes	0.81	42.92
AREG	-0.0002935	10160	GTEx	DepMap	Descartes	0.03	7.09

DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.56e-01
Mean rank of genes in gene set: 4156.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CST3	0.0016582	160	GTEx	DepMap	Descartes	15.01	1068.58
AGRP	-0.0000283	3633	GTEx	DepMap	Descartes	0.00	0.00
MMP9	-0.0002230	8676	GTEx	DepMap	Descartes	0.07	7.44

Monocytes: Non-classical monocytes (model markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.71e-01
Mean rank of genes in gene set: 4553.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BAG3	0.0007402	542	GTEx	DepMap	Descartes	6.57	545.78
RHOC	0.0002234	1501	GTEx	DepMap	Descartes	1.41	142.26
CUX2	-0.0001132	5734	GTEx	DepMap	Descartes	0.00	0.03
ABI3	-0.0003112	10437	GTEx	DepMap	Descartes	0.01	1.57

B cells: Transitional B cells (curated markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.85e-01
Mean rank of genes in gene set: 3030
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYO1C	6.7e-06	3030	GTEx	DepMap	Descartes	1.38	64.23

pDC precursor: pDC precursor (model markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.33e-01
Mean rank of genes in gene set: 3633
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	-2.83e-05	3633	GTEx	DepMap	Descartes	0	0

B cells: Germinal center B cells (curated markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.41e-01
Mean rank of genes in gene set: 4474
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD40	0.0000387	2630	GTEx	DepMap	Descartes	0.28	38.33
POU2AF1	-0.0001345	6318	GTEx	DepMap	Descartes	0.01	0.24

Macrophages: Hofbauer cells (model markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.46e-01
Mean rank of genes in gene set: 3791
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PANX2	-3.59e-05	3791	GTEx	DepMap	Descartes	0.02	1.21

Double-negative thymocytes: Double-negative thymocytes (model markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.76e-01
Mean rank of genes in gene set: 5395.83
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MFAP4	0.0064586	2	GTEx	DepMap	Descartes	12.90	1457.21
PDLIM1	0.0004074	996	GTEx	DepMap	Descartes	2.74	381.29
FXYD2	0.0002550	1379	GTEx	DepMap	Descartes	0.02	1.46
MZB1	-0.0001076	5593	GTEx	DepMap	Descartes	0.01	NA
CD7	-0.0005358	12168	GTEx	DepMap	Descartes	0.05	8.08
SELL	-0.0005626	12237	GTEx	DepMap	Descartes	0.09	8.45

Early MK: Early MK (model markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.78e-01
Mean rank of genes in gene set: 4769
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-5.42e-05	4209	GTEx	DepMap	Descartes	0	0
CCDC175	-9.88e-05	5329	GTEx	DepMap	Descartes	0	NA

Cycling cells: Cycling T cells (model markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.84e-01
Mean rank of genes in gene set: 4209
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-5.42e-05	4209	GTEx	DepMap	Descartes	0	0

ILC: ILC3 (model markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.84e-01
Mean rank of genes in gene set: 4209
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-5.42e-05	4209	GTEx	DepMap	Descartes	0	0

Promyelocytes: Promyelocytes (model markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.84e-01
Mean rank of genes in gene set: 4209
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-5.42e-05	4209	GTEx	DepMap	Descartes	0	0

DC: Migratory DCs (model markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.97e-01
Mean rank of genes in gene set: 4345
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-6.02e-05	4345	GTEx	DepMap	Descartes	0	0

Erythroid: Late erythroid (model markers)
late erythroid cells following early and middle erythroid cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.99e-01
Mean rank of genes in gene set: 4925.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000542	4209	GTEx	DepMap	Descartes	0	0.00
SLC12A3	-0.0001091	5642	GTEx	DepMap	Descartes	0	0.28

Epithelial cells: Epithelial cells (model markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.01e-01
Mean rank of genes in gene set: 4936
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDH3	-0.0000068	3236	GTEx	DepMap	Descartes	0.02	0.98
WFDC2	-0.0001456	6636	GTEx	DepMap	Descartes	0.02	4.43

T cells: Type 1 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.14e-01
Mean rank of genes in gene set: 5490.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CEBPB	0.0022051	92	GTEx	DepMap	Descartes	11.23	1514.91
ANXA1	0.0002371	1452	GTEx	DepMap	Descartes	11.04	1165.17
PRDM16	0.0000076	3014	GTEx	DepMap	Descartes	0.06	2.06
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16

T cells: Tem/Effector helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.26e-01
Mean rank of genes in gene set: 5331
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AQP3	4.55e-05	2564	GTEx	DepMap	Descartes	0.22	18.07
ITGB1	2.29e-05	2818	GTEx	DepMap	Descartes	2.79	166.00
KLRB1	-3.24e-04	10611	GTEx	DepMap	Descartes	0.00	0.71

B-cell lineage: Small pre-B cells (model markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.30e-01
Mean rank of genes in gene set: 5478.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000542	4209	GTEx	DepMap	Descartes	0.00	0.00
AICDA	-0.0000786	4810	GTEx	DepMap	Descartes	0.01	0.78
TLDC2	-0.0000897	5089	GTEx	DepMap	Descartes	0.00	NA
CD79B	-0.0001891	7807	GTEx	DepMap	Descartes	0.00	0.00

pDC: pDC (model markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.39e-01
Mean rank of genes in gene set: 5211.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TRIM71	0.0000242	2800	GTEx	DepMap	Descartes	0	0.02
OGDHL	-0.0001813	7623	GTEx	DepMap	Descartes	0	0.34

B cells: Germinal center B cells (model markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.40e-01
Mean rank of genes in gene set: 5216
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AICDA	-0.0000786	4810	GTEx	DepMap	Descartes	0.01	0.78
BMP3	-0.0001085	5622	GTEx	DepMap	Descartes	0.00	0.00

Granulocytes: Granulocytes (model markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.45e-01
Mean rank of genes in gene set: 5250.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC10A5	-0.0000379	3830	GTEx	DepMap	Descartes	0.01	1.09
MAK	-0.0001468	6671	GTEx	DepMap	Descartes	0.03	1.77

Megakaryocytes/platelets: Megakaryocytes/platelets (curated markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.74e-01
Mean rank of genes in gene set: 5450.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	-8.19e-05	4894	GTEx	DepMap	Descartes	0.02	0.83
CMTM5	-1.23e-04	6007	GTEx	DepMap	Descartes	0.00	0.00

Monocyte precursor: Monocyte precursor (model markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.00e-01
Mean rank of genes in gene set: 5622.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.0001050	5511	GTEx	DepMap	Descartes	0	0.02
CUX2	-0.0001132	5734	GTEx	DepMap	Descartes	0	0.03

Cycling cells: Cycling DCs (model markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.08e-01
Mean rank of genes in gene set: 5427
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP12	-0.0001024	5427	GTEx	DepMap	Descartes	0.05	4.8

HSC/MPP: Early lymphoid/T lymphoid (model markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-01
Mean rank of genes in gene set: 5511
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.000105	5511	GTEx	DepMap	Descartes	0	0.02

HSC/MPP: CMP (model markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.35e-01
Mean rank of genes in gene set: 5853.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000542	4209	GTEx	DepMap	Descartes	0.00	0.00
CPA3	-0.0001763	7498	GTEx	DepMap	Descartes	0.02	2.44

HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.41e-01
Mean rank of genes in gene set: 5734
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0001132	5734	GTEx	DepMap	Descartes	0	0.03

HSC/MPP: HSC/MPP (model markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.56e-01
Mean rank of genes in gene set: 5988.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPINK2	-4.98e-05	4100	GTEx	DepMap	Descartes	0	0
GRIN1	-1.92e-04	7877	GTEx	DepMap	Descartes	0	0

Early MK: Early MK (curated markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.71e-01
Mean rank of genes in gene set: 6007
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	-0.000123	6007	GTEx	DepMap	Descartes	0	0

B cells: Follicular B cells (curated markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.06e-01
Mean rank of genes in gene set: 6311.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-0.0000985	5320	GTEx	DepMap	Descartes	0.04	3.43
CD22	-0.0001695	7303	GTEx	DepMap	Descartes	0.02	0.85

Cycling cells: Cycling B cells (model markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.14e-01
Mean rank of genes in gene set: 6348.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.TPM
CD207	-0.0000542	4209	GTEx	DepMap	Descartes	0.00
RGS13	-0.0001573	6960	GTEx	DepMap	Descartes	0.03
GRIN1	-0.0001920	7877	GTEx	DepMap	Descartes	0.00

Megakaryocyte precursor: Megakaryocyte precursor (model markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.16e-01
Mean rank of genes in gene set: 6375
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC10A5	-0.0000379	3830	GTEx	DepMap	Descartes	0.01	1.09
ADRA2A	-0.0002336	8920	GTEx	DepMap	Descartes	0.24	15.93

Erythroid: Early erythroid (model markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.40e-01
Mean rank of genes in gene set: 6456
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000542	4209	GTEx	DepMap	Descartes	0.00	0.00
PRSS57	-0.0000664	4507	GTEx	DepMap	Descartes	0.00	0.00
FAM178B	-0.0001772	7521	GTEx	DepMap	Descartes	0.00	0.04
APOC1	-0.0002645	9587	GTEx	DepMap	Descartes	0.36	112.09

T cells: Tcm/Naive helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.52e-01
Mean rank of genes in gene set: 6511.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTSL	0.0008435	454	GTEx	DepMap	Descartes	5.96	NA
FCGRT	0.0002895	1280	GTEx	DepMap	Descartes	1.83	158.45
LTB	-0.0004498	11780	GTEx	DepMap	Descartes	0.03	2.68
TMSB10	-0.0010223	12531	GTEx	DepMap	Descartes	9.22	4514.98

DC: DC3 (model markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.54e-01
Mean rank of genes in gene set: 6622.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0001085	5622	GTEx	DepMap	Descartes	0	0.00
OGDHL	-0.0001813	7623	GTEx	DepMap	Descartes	0	0.34

B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.65e-01
Mean rank of genes in gene set: 6692.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
YBX3	0.0004559	908	GTEx	DepMap	Descartes	4.01	NA
CD74	-0.0007647	12477	GTEx	DepMap	Descartes	6.62	451.39

T cells: Type 17 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.67e-01
Mean rank of genes in gene set: 6707
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZBTB16	0.0003642	1083	GTEx	DepMap	Descartes	0.60	17.70
IL7R	-0.0006124	12331	GTEx	DepMap	Descartes	0.16	9.26

T cells: Regulatory T cells (curated markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.70e-01
Mean rank of genes in gene set: 6915
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-0.0001557	6915	GTEx	DepMap	Descartes	0.01	1.52

ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.76e-01
Mean rank of genes in gene set: 6675.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCN1B	-0.0000554	4243	GTEx	DepMap	Descartes	0.13	5.82
HPN	-0.0001080	5604	GTEx	DepMap	Descartes	0.00	0.00
LST1	-0.0002953	10179	GTEx	DepMap	Descartes	0.03	4.28

Granulocytes: Granulocytes (curated markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.76e-01
Mean rank of genes in gene set: 6678
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC45A3	-0.0000243	3556	GTEx	DepMap	Descartes	0.03	1.30
CPA3	-0.0001763	7498	GTEx	DepMap	Descartes	0.02	2.44
KIT	-0.0002366	8980	GTEx	DepMap	Descartes	0.03	1.31

DC: DC1 (curated markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.86e-01
Mean rank of genes in gene set: 6828
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BATF3	0.0002965	1263	GTEx	DepMap	Descartes	0.24	24.83
CADM1	-0.0006544	12393	GTEx	DepMap	Descartes	0.22	3.39

B cells: B cells (curated markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.96e-01
Mean rank of genes in gene set: 6894
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0001299	6192	GTEx	DepMap	Descartes	0.00	0.12
CD79A	-0.0001801	7596	GTEx	DepMap	Descartes	0.02	6.77

Double-negative thymocytes: Double-negative thymocytes (curated markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.04e-01
Mean rank of genes in gene set: 6951
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FXYD2	0.0002550	1379	GTEx	DepMap	Descartes	0.02	1.46
HES1	-0.0009271	12523	GTEx	DepMap	Descartes	2.46	358.41

ILC: CD16- NK cells (curated markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.07e-01
Mean rank of genes in gene set: 7260
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD160	-0.0001681	7260	GTEx	DepMap	Descartes	0	0

T cells: Follicular helper T cells (curated markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.07e-01
Mean rank of genes in gene set: 6972.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-9.85e-05	5320	GTEx	DepMap	Descartes	0.04	3.43
PDCD1	-2.21e-04	8625	GTEx	DepMap	Descartes	0.00	0.55

Mast cells: Mast cells (model markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.32e-01
Mean rank of genes in gene set: 7498
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	-0.0001763	7498	GTEx	DepMap	Descartes	0.02	2.44

Mast cells: Mast cells (curated markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.38e-01
Mean rank of genes in gene set: 7176
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPSB2	-0.0001532	6854	GTEx	DepMap	Descartes	0.03	8.67
CPA3	-0.0001763	7498	GTEx	DepMap	Descartes	0.02	2.44

T cells: T(agonist) (curated markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.44e-01
Mean rank of genes in gene set: 7044.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SMS	0.0000693	2370	GTEx	DepMap	Descartes	0.63	86.41
MIR155HG	-0.0001796	7576	GTEx	DepMap	Descartes	0.25	38.07
BIRC3	-0.0003724	11188	GTEx	DepMap	Descartes	1.53	42.58

DC precursor: DC precursor (model markers)
dendritic cell precursors that differentiate into dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.45e-01
Mean rank of genes in gene set: 7623
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	-0.0001813	7623	GTEx	DepMap	Descartes	0	0.34

B-cell lineage: Large pre-B cells (model markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.54e-01
Mean rank of genes in gene set: 7705
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.000185	7705	GTEx	DepMap	Descartes	0	0.45

DC: DC1 (model markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.54e-01
Mean rank of genes in gene set: 7705
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.000185	7705	GTEx	DepMap	Descartes	0	0.45

Erythrocytes: Erythrocytes (model markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.54e-01
Mean rank of genes in gene set: 7705
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.000185	7705	GTEx	DepMap	Descartes	0	0.45

T cells: Tem/Effector helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.69e-01
Mean rank of genes in gene set: 6919.83
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0002371	1452	GTEx	DepMap	Descartes	11.04	1165.17
AQP3	0.0000455	2564	GTEx	DepMap	Descartes	0.22	18.07
DONSON	-0.0000882	5060	GTEx	DepMap	Descartes	0.21	20.55
S100A4	-0.0002877	10052	GTEx	DepMap	Descartes	0.96	354.52
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
LTB	-0.0004498	11780	GTEx	DepMap	Descartes	0.03	2.68

T cells: Follicular helper T cells (model markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.82e-01
Mean rank of genes in gene set: 7134
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOCS3	0.0004688	885	GTEx	DepMap	Descartes	7.16	795.11
CH25H	-0.0002068	8275	GTEx	DepMap	Descartes	0.07	9.57
HOXB5	-0.0002273	8765	GTEx	DepMap	Descartes	0.01	1.46
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71

pDC: pDC (curated markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.89e-01
Mean rank of genes in gene set: 8064
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLD4	-0.0001987	8064	GTEx	DepMap	Descartes	0.01	0.6

Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.95e-01
Mean rank of genes in gene set: 7339.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0006207	651	GTEx	DepMap	Descartes	42.92	501.95
SAT1	-0.0002549	9379	GTEx	DepMap	Descartes	4.66	949.93
TYROBP	-0.0004916	11988	GTEx	DepMap	Descartes	0.37	130.77

T cells: Type 17 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.00e-01
Mean rank of genes in gene set: 7371.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0002371	1452	GTEx	DepMap	Descartes	11.04	1165.17
S100A4	-0.0002877	10052	GTEx	DepMap	Descartes	0.96	354.52
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71

ILC: ILC3 (curated markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.14e-01
Mean rank of genes in gene set: 7454
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RORC	-0.0000886	5066	GTEx	DepMap	Descartes	0.00	0.00
IL4I1	-0.0002083	8316	GTEx	DepMap	Descartes	0.01	0.43
KIT	-0.0002366	8980	GTEx	DepMap	Descartes	0.03	1.31

ILC: Transitional NK (model markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.16e-01
Mean rank of genes in gene set: 7311.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	0.0000076	3014	GTEx	DepMap	Descartes	0.06	2.06
AGRP	-0.0000283	3633	GTEx	DepMap	Descartes	0.00	0.00
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
TYROBP	-0.0004916	11988	GTEx	DepMap	Descartes	0.37	130.77

Macrophages: Kupffer cells (model markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.29e-01
Mean rank of genes in gene set: 7378.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0001110	2054	GTEx	DepMap	Descartes	0.16	48.22
CD5L	-0.0000735	4687	GTEx	DepMap	Descartes	0.13	7.99
EGR2	-0.0003096	10418	GTEx	DepMap	Descartes	1.09	74.02
ARRDC3	-0.0006243	12354	GTEx	DepMap	Descartes	0.76	35.97

Megakaryocyte precursor: Megakaryocyte precursor (curated markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.52e-01
Mean rank of genes in gene set: 8015
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRSS57	-0.0000664	4507	GTEx	DepMap	Descartes	0.00	0.00
GATA2	-0.0004072	11523	GTEx	DepMap	Descartes	0.12	5.31

Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.55e-01
Mean rank of genes in gene set: 7721.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	0.0004911	843	GTEx	DepMap	Descartes	5.63	399.48
CLDN5	-0.0003148	10487	GTEx	DepMap	Descartes	0.02	1.84
PLVAP	-0.0004609	11834	GTEx	DepMap	Descartes	0.36	20.94

ILC: CD16- NK cells (model markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.66e-01
Mean rank of genes in gene set: 7269.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCL3	0.0014511	209	GTEx	DepMap	Descartes	12.79	1956.85
GSTP1	0.0001560	1776	GTEx	DepMap	Descartes	1.95	243.73
LDB2	-0.0001502	6780	GTEx	DepMap	Descartes	0.43	32.78
CLIC3	-0.0001831	7657	GTEx	DepMap	Descartes	0.01	2.30
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
FCER1G	-0.0004666	11866	GTEx	DepMap	Descartes	0.14	49.75
TYROBP	-0.0004916	11988	GTEx	DepMap	Descartes	0.37	130.77

Macrophages: Macrophages (curated markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.68e-01
Mean rank of genes in gene set: 8933
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD68	-0.000234	8933	GTEx	DepMap	Descartes	0.4	48.53

T cells: MAIT cells (curated markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.74e-01
Mean rank of genes in gene set: 8205
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC4A10	-0.0001152	5799	GTEx	DepMap	Descartes	0	0.00
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0	0.71

HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.75e-01
Mean rank of genes in gene set: 8208.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	-0.0000819	4894	GTEx	DepMap	Descartes	0.02	0.83
GATA2	-0.0004072	11523	GTEx	DepMap	Descartes	0.12	5.31

Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.78e-01
Mean rank of genes in gene set: 7663
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
APOE	-0.0000433	3944	GTEx	DepMap	Descartes	6.78	1302.39
CD5L	-0.0000735	4687	GTEx	DepMap	Descartes	0.13	7.99
APOC1	-0.0002645	9587	GTEx	DepMap	Descartes	0.36	112.09
FTH1	-0.0007020	12434	GTEx	DepMap	Descartes	20.49	3595.84

Monocytes: Classical monocytes (curated markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.96e-01
Mean rank of genes in gene set: 9269
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD14	-0.00025	9269	GTEx	DepMap	Descartes	0.31	37.41

HSC/MPP: Early lymphoid/T lymphoid (curated markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.98e-01
Mean rank of genes in gene set: 8410
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ETS1	-0.0000613	4378	GTEx	DepMap	Descartes	3.35	137.37
GATA3	-0.0007107	12442	GTEx	DepMap	Descartes	0.05	2.93

T cells: gamma-delta T cells (model markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.01e-01
Mean rank of genes in gene set: 8046
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.TPM
KLRC2	-0.0001801	7595	GTEx	DepMap	Descartes	0.34
GRIN1	-0.0001920	7877	GTEx	DepMap	Descartes	0.00
KCNK10	-0.0002225	8666	GTEx	DepMap	Descartes	0.00

ILC: NK cells (model markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.19e-01
Mean rank of genes in gene set: 7524.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CST3	0.0016582	160	GTEx	DepMap	Descartes	15.01	1068.58
IGFBP4	0.0016437	164	GTEx	DepMap	Descartes	12.72	1265.36
SPINK2	-0.0000498	4100	GTEx	DepMap	Descartes	0.00	0.00
HMOX1	-0.0004553	11803	GTEx	DepMap	Descartes	2.36	309.54
KLHL23	-0.0004560	11807	GTEx	DepMap	Descartes	0.10	5.34
MALAT1	-0.0005219	12122	GTEx	DepMap	Descartes	96.67	2925.91
STMN1	-0.0008845	12516	GTEx	DepMap	Descartes	0.44	30.86

Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.31e-01
Mean rank of genes in gene set: 8725.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	-0.0001920	7877	GTEx	DepMap	Descartes	0.00	0.00
KL	-0.0002638	9574	GTEx	DepMap	Descartes	0.02	0.59

ILC: CD16+ NK cells (model markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.33e-01
Mean rank of genes in gene set: 7838.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADAMTS1	0.0005843	700	GTEx	DepMap	Descartes	6.21	268.37
PRSS57	-0.0000664	4507	GTEx	DepMap	Descartes	0.00	0.00
IGFBP7	-0.0002918	10131	GTEx	DepMap	Descartes	58.65	8991.02
FCER1G	-0.0004666	11866	GTEx	DepMap	Descartes	0.14	49.75
TYROBP	-0.0004916	11988	GTEx	DepMap	Descartes	0.37	130.77

B cells: Memory B cells (curated markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.45e-01
Mean rank of genes in gene set: 9958
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD27	-0.0002833	9958	GTEx	DepMap	Descartes	0	0.39

B-cell lineage: Small pre-B cells (curated markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.50e-01
Mean rank of genes in gene set: 10022
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0002861	10022	GTEx	DepMap	Descartes	0.07	2.45

B-cell lineage: Pro-B cells (curated markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.50e-01
Mean rank of genes in gene set: 10022
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0002861	10022	GTEx	DepMap	Descartes	0.07	2.45

B cells: Follicular B cells (model markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.68e-01
Mean rank of genes in gene set: 9133.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VPREB3	-0.0001401	6474	GTEx	DepMap	Descartes	0.0	0.00
CD83	-0.0004524	11793	GTEx	DepMap	Descartes	0.7	50.45

T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.70e-01
Mean rank of genes in gene set: 8097.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD44	0.0002845	1291	GTEx	DepMap	Descartes	6.80	316.02
ITM2A	0.0001008	2129	GTEx	DepMap	Descartes	1.83	236.40
MALAT1	-0.0005219	12122	GTEx	DepMap	Descartes	96.67	2925.91
SATB1	-0.0006798	12413	GTEx	DepMap	Descartes	0.13	2.61
TMSB10	-0.0010223	12531	GTEx	DepMap	Descartes	9.22	4514.98

T cells: NKT cells (model markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.71e-01
Mean rank of genes in gene set: 8635.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	0.0000076	3014	GTEx	DepMap	Descartes	0.06	2.06
ITM2C	-0.0003231	10603	GTEx	DepMap	Descartes	1.05	103.90
CD52	-0.0005867	12290	GTEx	DepMap	Descartes	0.02	6.16

Macrophages: Hofbauer cells (curated markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.80e-01
Mean rank of genes in gene set: 10529
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCIN	-0.0003173	10529	GTEx	DepMap	Descartes	0.02	0.41

Mono-mac: Mono-mac (model markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.89e-01
Mean rank of genes in gene set: 8487.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A2	0.0002170	1525	GTEx	DepMap	Descartes	0.04	11.74
SAT1	-0.0002549	9379	GTEx	DepMap	Descartes	4.66	949.93
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
FTH1	-0.0007020	12434	GTEx	DepMap	Descartes	20.49	3595.84

Cycling cells: Cycling B cells (curated markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.91e-01
Mean rank of genes in gene set: 8853.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0001299	6192	GTEx	DepMap	Descartes	0.00	0.12
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.99e-01
Mean rank of genes in gene set: 9544.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDX2	-0.0002333	8911	GTEx	DepMap	Descartes	0.68	81.89
KCNH2	-0.0002951	10178	GTEx	DepMap	Descartes	0.01	0.18

ILC: ILC2 (curated markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.11e-01
Mean rank of genes in gene set: 9090.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPGDS	-0.0001465	6664	GTEx	DepMap	Descartes	0.00	0.00
KLRG1	-0.0002029	8166	GTEx	DepMap	Descartes	0.01	1.04
GATA3	-0.0007107	12442	GTEx	DepMap	Descartes	0.05	2.93

B-cell lineage: Large pre-B cells (curated markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.11e-01
Mean rank of genes in gene set: 9728
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
MME	-0.0002861	10022	GTEx	DepMap	Descartes	0.07	2.45

B cells: Transitional B cells (model markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.25e-01
Mean rank of genes in gene set: 11501
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GNG3	-0.000405	11501	GTEx	DepMap	Descartes	0.01	1.46

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (curated markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.26e-01
Mean rank of genes in gene set: 11523
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GATA2	-0.0004072	11523	GTEx	DepMap	Descartes	0.12	5.31

T cells: CD8a/a (curated markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10122.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0002210	8625	GTEx	DepMap	Descartes	0.00	0.55
GNG4	-0.0004219	11620	GTEx	DepMap	Descartes	0.06	2.11

Double-positive thymocytes: Double-positive thymocytes (model markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.36e-01
Mean rank of genes in gene set: 8529
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RAG2	-0.0001132	5736	GTEx	DepMap	Descartes	0.00	0.00
ARPP21	-0.0001229	6005	GTEx	DepMap	Descartes	0.00	0.20
ELOVL4	-0.0001463	6651	GTEx	DepMap	Descartes	0.12	6.80
SH3TC1	-0.0002201	8605	GTEx	DepMap	Descartes	0.01	0.14
SMPD3	-0.0004713	11887	GTEx	DepMap	Descartes	0.01	0.14
CD52	-0.0005867	12290	GTEx	DepMap	Descartes	0.02	6.16

T cells: NKT cells (curated markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.36e-01
Mean rank of genes in gene set: 11798
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85

Cycling cells: Cycling DCs (curated markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.37e-01
Mean rank of genes in gene set: 10184.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.37e-01
Mean rank of genes in gene set: 10184.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.37e-01
Mean rank of genes in gene set: 10184.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Cycling cells: Cycling NK cells (curated markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.37e-01
Mean rank of genes in gene set: 10184.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Cycling cells: Cycling T cells (curated markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.37e-01
Mean rank of genes in gene set: 10184.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0002572	9434	GTEx	DepMap	Descartes	0.01	0.09
TOP2A	-0.0003480	10935	GTEx	DepMap	Descartes	0.01	0.47

Monocytes: Classical monocytes (model markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.40e-01
Mean rank of genes in gene set: 9533
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000542	4209	GTEx	DepMap	Descartes	0.00	0.00
CST7	-0.0004632	11851	GTEx	DepMap	Descartes	0.04	12.98
EEF1A1	-0.0011323	12539	GTEx	DepMap	Descartes	9.75	354.50

ILC: ILC1 (curated markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.42e-01
Mean rank of genes in gene set: 11972
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF3	-0.0004879	11972	GTEx	DepMap	Descartes	0.02	0.59

T cells: MAIT cells (model markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.46e-01
Mean rank of genes in gene set: 9182.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0001085	5622	GTEx	DepMap	Descartes	0.00	0.00
KLRG1	-0.0002029	8166	GTEx	DepMap	Descartes	0.01	1.04
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
IL7R	-0.0006124	12331	GTEx	DepMap	Descartes	0.16	9.26

T cells: Tem/Effector helper T cells PD1+ (curated markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.48e-01
Mean rank of genes in gene set: 10449.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0002210	8625	GTEx	DepMap	Descartes	0.00	0.55
CD4	-0.0005803	12274	GTEx	DepMap	Descartes	0.15	8.00

T cells: Type 1 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.50e-01
Mean rank of genes in gene set: 10493.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TBX21	-0.0002245	8702	GTEx	DepMap	Descartes	0.00	1.05
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16

ILC: Transitional NK (curated markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.51e-01
Mean rank of genes in gene set: 12285
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16

T cells: gamma-delta T cells (curated markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.51e-01
Mean rank of genes in gene set: 12285
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16

T cells: Tem/Temra cytotoxic T cells (model markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 12331
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0006124	12331	GTEx	DepMap	Descartes	0.16	9.26

DC: DC (model markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.55e-01
Mean rank of genes in gene set: 12403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0006673	12403	GTEx	DepMap	Descartes	0.71	28.37

pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.55e-01
Mean rank of genes in gene set: 10609
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IRF7	-0.0002836	9966	GTEx	DepMap	Descartes	0.28	38.26
CCDC50	-0.0003782	11252	GTEx	DepMap	Descartes	0.76	17.87

T cells: CD8a/b(entry) (curated markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.55e-01
Mean rank of genes in gene set: 12413
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SATB1	-0.0006798	12413	GTEx	DepMap	Descartes	0.13	2.61

T cells: Treg(diff) (curated markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.56e-01
Mean rank of genes in gene set: 9846.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF4	-0.0001861	7737	GTEx	DepMap	Descartes	0.25	12.30
CD27	-0.0002833	9958	GTEx	DepMap	Descartes	0.00	0.39
CCR7	-0.0004620	11844	GTEx	DepMap	Descartes	0.10	10.28

Macrophages: Kidney-resident macrophages (curated markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 12477
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	-0.0007647	12477	GTEx	DepMap	Descartes	6.62	451.39

B-cell lineage: Pre-pro-B cells (curated markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.59e-01
Mean rank of genes in gene set: 10716
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZCCHC7	-0.0002420	9101	GTEx	DepMap	Descartes	0.09	5.83
IL7R	-0.0006124	12331	GTEx	DepMap	Descartes	0.16	9.26

HSC/MPP: ELP (curated markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.62e-01
Mean rank of genes in gene set: 10818.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RUNX2	-0.0002775	9857	GTEx	DepMap	Descartes	0.15	6.81
LTB	-0.0004498	11780	GTEx	DepMap	Descartes	0.03	2.68

DC: Migratory DCs (curated markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.65e-01
Mean rank of genes in gene set: 10902.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EBI3	-0.0002834	9961	GTEx	DepMap	Descartes	0.01	1.35
CCR7	-0.0004620	11844	GTEx	DepMap	Descartes	0.10	10.28

T cells: Trm cytotoxic T cells (curated markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.67e-01
Mean rank of genes in gene set: 10966.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGAE	-0.0002975	10228	GTEx	DepMap	Descartes	0.07	3.23
ITGA1	-0.0004354	11705	GTEx	DepMap	Descartes	2.22	43.27

T cells: Memory CD4+ cytotoxic T cells (curated markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.81e-01
Mean rank of genes in gene set: 11591
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL10	-0.0003464	10908	GTEx	DepMap	Descartes	0.03	5.45
CD4	-0.0005803	12274	GTEx	DepMap	Descartes	0.15	8.00

Erythroid: Early erythroid (curated markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.83e-01
Mean rank of genes in gene set: 10694.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
APOC1	-0.0002645	9587	GTEx	DepMap	Descartes	0.36	112.09
TESPA1	-0.0003525	10974	GTEx	DepMap	Descartes	0.01	NA
GATA2	-0.0004072	11523	GTEx	DepMap	Descartes	0.12	5.31

B cells: B cells (model markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.83e-01
Mean rank of genes in gene set: 10731.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-0.0001801	7596	GTEx	DepMap	Descartes	0.02	6.77
MALAT1	-0.0005219	12122	GTEx	DepMap	Descartes	96.67	2925.91
CD74	-0.0007647	12477	GTEx	DepMap	Descartes	6.62	451.39

Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 10148
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VWF	-0.0001775	7532	GTEx	DepMap	Descartes	1.78	24.39
RAMP3	-0.0003154	10497	GTEx	DepMap	Descartes	0.06	7.96
JAM2	-0.0003725	11192	GTEx	DepMap	Descartes	0.45	18.65
MMRN2	-0.0003889	11371	GTEx	DepMap	Descartes	0.10	2.54

Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 9768.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A6	0.0005490	744	GTEx	DepMap	Descartes	7.07	2691.79
ACTB	-0.0003668	11142	GTEx	DepMap	Descartes	21.48	2046.94
TYROBP	-0.0004916	11988	GTEx	DepMap	Descartes	0.37	130.77
FTH1	-0.0007020	12434	GTEx	DepMap	Descartes	20.49	3595.84
SRGN	-0.0010366	12534	GTEx	DepMap	Descartes	3.69	636.37

Double-positive thymocytes: Double-positive thymocytes (curated markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.85e-01
Mean rank of genes in gene set: 11842.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
SMPD3	-0.0004713	11887	GTEx	DepMap	Descartes	0.01	0.14

ILC: ILC (model markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-01
Mean rank of genes in gene set: 10244.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	-0.0001920	7877	GTEx	DepMap	Descartes	0.00	0.00
AREG	-0.0002935	10160	GTEx	DepMap	Descartes	0.03	7.09
KLRB1	-0.0003240	10611	GTEx	DepMap	Descartes	0.00	0.71
IL7R	-0.0006124	12331	GTEx	DepMap	Descartes	0.16	9.26

Mono-mac: Mono-mac (curated markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-01
Mean rank of genes in gene set: 11895.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HMOX1	-0.0004553	11803	GTEx	DepMap	Descartes	2.36	309.54
TYROBP	-0.0004916	11988	GTEx	DepMap	Descartes	0.37	130.77

T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 9338.86
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITM2A	0.0001008	2129	GTEx	DepMap	Descartes	1.83	236.40
SMS	0.0000693	2370	GTEx	DepMap	Descartes	0.63	86.41
BIRC3	-0.0003724	11188	GTEx	DepMap	Descartes	1.53	42.58
COTL1	-0.0005330	12156	GTEx	DepMap	Descartes	1.05	42.42
CD74	-0.0007647	12477	GTEx	DepMap	Descartes	6.62	451.39
PTPRC	-0.0008493	12505	GTEx	DepMap	Descartes	0.15	5.98
B2M	-0.0014897	12547	GTEx	DepMap	Descartes	24.43	2224.21

T cells: Tem/Trm cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.88e-01
Mean rank of genes in gene set: 12041.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16

T cells: Tcm/Naive cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 12172.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
B2M	-0.0014897	12547	GTEx	DepMap	Descartes	24.43	2224.21

B cells: Memory B cells (model markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12500
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	-0.0007647	12477	GTEx	DepMap	Descartes	6.62	451.39
HES1	-0.0009271	12523	GTEx	DepMap	Descartes	2.46	358.41

T cells: Regulatory T cells (model markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 10972
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RTKN2	-0.0002311	8856	GTEx	DepMap	Descartes	0.05	1.44
TIGIT	-0.0002902	10095	GTEx	DepMap	Descartes	0.01	0.46
RGS1	-0.0006673	12403	GTEx	DepMap	Descartes	0.71	28.37
SRGN	-0.0010366	12534	GTEx	DepMap	Descartes	3.69	636.37

T cells: Tcm/Naive cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 11959.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
CCR7	-0.0004620	11844	GTEx	DepMap	Descartes	0.10	10.28
SELL	-0.0005626	12237	GTEx	DepMap	Descartes	0.09	8.45

T cells: Tem/Trm cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 11978
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
CST7	-0.0004632	11851	GTEx	DepMap	Descartes	0.04	12.98
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16

T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 10088.29
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NUCB2	0.0003320	1165	GTEx	DepMap	Descartes	0.79	46.76
CD27	-0.0002833	9958	GTEx	DepMap	Descartes	0.00	0.39
CTSW	-0.0003731	11195	GTEx	DepMap	Descartes	0.02	5.34
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
MALAT1	-0.0005219	12122	GTEx	DepMap	Descartes	96.67	2925.91
LEF1	-0.0005226	12126	GTEx	DepMap	Descartes	0.17	7.33
PRKCH	-0.0005724	12254	GTEx	DepMap	Descartes	0.13	5.30

T cells: Tcm/Naive helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 12118.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCR7	-0.0004620	11844	GTEx	DepMap	Descartes	0.10	10.28
SELL	-0.0005626	12237	GTEx	DepMap	Descartes	0.09	8.45
CD4	-0.0005803	12274	GTEx	DepMap	Descartes	0.15	8.00

T cells: Trm cytotoxic T cells (model markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 12138
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0004542	11798	GTEx	DepMap	Descartes	0.01	0.85
CCL5	-0.0005858	12285	GTEx	DepMap	Descartes	0.07	15.16
IL7R	-0.0006124	12331	GTEx	DepMap	Descartes	0.16	9.26

T cells: Treg(diff) (model markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 11462.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A4	-0.0002877	10052	GTEx	DepMap	Descartes	0.96	354.52
TSC22D3	-0.0003449	10889	GTEx	DepMap	Descartes	2.10	205.45
RGS1	-0.0006673	12403	GTEx	DepMap	Descartes	0.71	28.37
PTPRC	-0.0008493	12505	GTEx	DepMap	Descartes	0.15	5.98

B cells: Naive B cells (curated markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
DC: DC (curated markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
DC: DC2 (curated markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
DC: DC3 (curated markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
DC precursor: DC precursor (curated markers)
dendritic cell precursors that differentiate into dendritic cells:
Erythrocytes: Erythrocytes (curated markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Erythroid: Late erythroid (curated markers)
late erythroid cells following early and middle erythroid cells:
HSC/MPP: CMP (curated markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
HSC/MPP: GMP (curated markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: Neutrophil-myeloid progenitor (curated markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
ILC: CD16+ NK cells (curated markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
ILC: NK cells (curated markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Monocytes: Non-classical monocytes (curated markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Monocytes: Monocytes (curated markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Myelocytes: Myelocytes (curated markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Promyelocytes: Promyelocytes (curated markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
T cells: Tem/Temra cytotoxic T cells (curated markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
B-cell lineage: Pre-pro-B cells (model markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
B-cell lineage: Pro-B cells (model markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Cycling cells: Cycling gamma-delta T cells (model markers)
proliferating gamma-delta (γδ) T lymphocytes:
Cycling cells: Cycling monocytes (model markers)
proliferating monocytes:
DC: Transitional DC (model markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Erythroid: Mid erythroid (model markers)
middle erythroid cells in fetal liver:
Granulocytes: Neutrophils (model markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
HSC/MPP: ELP (model markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
HSC/MPP: GMP (model markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: MEMP (model markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
ILC: ILC1 (model markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Macrophages: Kidney-resident macrophages (model markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Megakaryocytes/platelets: Megakaryocytes/platelets (model markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
MNP: MNP (model markers)
mononuclear phagocytes including dendritic cells: