Program: 8. Cell Cycle (G2-M).

Program: 8. Cell Cycle (G2-M).



Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 UBE2C 0.0184282 ubiquitin conjugating enzyme E2 C GTEx DepMap Descartes 23.13 4368.66
2 CENPF 0.0181907 centromere protein F GTEx DepMap Descartes 22.37 336.40
3 CCNB1 0.0171352 cyclin B1 GTEx DepMap Descartes 7.93 662.30
4 TOP2A 0.0169205 DNA topoisomerase II alpha GTEx DepMap Descartes 18.45 517.59
5 TPX2 0.0161480 TPX2 microtubule nucleation factor GTEx DepMap Descartes 6.22 273.06
6 PTTG1 0.0153838 PTTG1 regulator of sister chromatid separation, securin GTEx DepMap Descartes 13.92 2315.89
7 PLK1 0.0153623 polo like kinase 1 GTEx DepMap Descartes 3.20 136.42
8 ASPM 0.0151844 assembly factor for spindle microtubules GTEx DepMap Descartes 5.20 80.58
9 NUF2 0.0151274 NUF2 component of NDC80 kinetochore complex GTEx DepMap Descartes 4.88 418.67
10 CENPA 0.0150439 centromere protein A GTEx DepMap Descartes 3.43 414.99
11 CDC20 0.0149641 cell division cycle 20 GTEx DepMap Descartes 3.40 325.71
12 CCNB2 0.0149111 cyclin B2 GTEx DepMap Descartes 6.04 425.68
13 KPNA2 0.0148472 karyopherin subunit alpha 2 GTEx DepMap Descartes 14.12 1005.78
14 HMMR 0.0147243 hyaluronan mediated motility receptor GTEx DepMap Descartes 3.27 178.00
15 NUSAP1 0.0143347 nucleolar and spindle associated protein 1 GTEx DepMap Descartes 6.95 369.90
16 CDKN3 0.0138217 cyclin dependent kinase inhibitor 3 GTEx DepMap Descartes 4.96 794.93
17 NEK2 0.0136249 NIMA related kinase 2 GTEx DepMap Descartes 1.76 135.98
18 DLGAP5 0.0135212 DLG associated protein 5 GTEx DepMap Descartes 2.44 132.43
19 MKI67 0.0134630 marker of proliferation Ki-67 GTEx DepMap Descartes 8.80 114.09
20 TUBB4B 0.0133196 tubulin beta 4B class IVb GTEx DepMap Descartes 12.80 1028.45
21 CENPE 0.0132991 centromere protein E GTEx DepMap Descartes 3.02 57.62
22 GTSE1 0.0131585 G2 and S-phase expressed 1 GTEx DepMap Descartes 4.67 259.11
23 HMGB2 0.0128221 high mobility group box 2 GTEx DepMap Descartes 27.70 2513.87
24 BIRC5 0.0126678 baculoviral IAP repeat containing 5 GTEx DepMap Descartes 9.17 535.61
25 KIF14 0.0126279 kinesin family member 14 GTEx DepMap Descartes 1.63 36.41
26 CCNA2 0.0125105 cyclin A2 GTEx DepMap Descartes 2.51 151.83
27 CDCA8 0.0122076 cell division cycle associated 8 GTEx DepMap Descartes 1.81 125.86
28 ARL6IP1 0.0119668 ADP ribosylation factor like GTPase 6 interacting protein 1 GTEx DepMap Descartes 10.57 815.71
29 KIF20A 0.0118781 kinesin family member 20A GTEx DepMap Descartes 1.51 78.56
30 KNSTRN 0.0118293 kinetochore localized astrin (SPAG5) binding protein GTEx DepMap Descartes 3.30 NA
31 AURKA 0.0116085 aurora kinase A GTEx DepMap Descartes 1.96 153.46
32 KIF23 0.0115762 kinesin family member 23 GTEx DepMap Descartes 1.94 85.48
33 KIF2C 0.0114855 kinesin family member 2C GTEx DepMap Descartes 1.81 95.21
34 CKAP2 0.0114454 cytoskeleton associated protein 2 GTEx DepMap Descartes 4.19 200.25
35 PBK 0.0110718 PDZ binding kinase GTEx DepMap Descartes 3.55 302.30
36 GAS2L3 0.0110186 growth arrest specific 2 like 3 GTEx DepMap Descartes 1.23 37.53
37 TTK 0.0110184 TTK protein kinase GTEx DepMap Descartes 1.68 72.82
38 ECT2 0.0109904 epithelial cell transforming 2 GTEx DepMap Descartes 2.27 87.96
39 CKAP2L 0.0107893 cytoskeleton associated protein 2 like GTEx DepMap Descartes 2.16 76.06
40 TROAP 0.0107245 trophinin associated protein GTEx DepMap Descartes 2.24 150.69
41 CKS1B 0.0106687 CDC28 protein kinase regulatory subunit 1B GTEx DepMap Descartes 11.14 1559.95
42 CEP55 0.0106518 centrosomal protein 55 GTEx DepMap Descartes 1.18 70.98
43 CKS2 0.0105941 CDC28 protein kinase regulatory subunit 2 GTEx DepMap Descartes 8.95 2428.52
44 ARHGAP11A 0.0105926 Rho GTPase activating protein 11A GTEx DepMap Descartes 1.87 50.43
45 CDCA3 0.0105902 cell division cycle associated 3 GTEx DepMap Descartes 1.32 74.99
46 NDC80 0.0105842 NDC80 kinetochore complex component GTEx DepMap Descartes 2.16 163.15
47 CDK1 0.0105786 cyclin dependent kinase 1 GTEx DepMap Descartes 4.35 341.08
48 BUB1 0.0100374 BUB1 mitotic checkpoint serine/threonine kinase GTEx DepMap Descartes 1.11 48.07
49 PRC1 0.0098518 protein regulator of cytokinesis 1 GTEx DepMap Descartes 3.20 139.28
50 KIFC1 0.0096579 kinesin family member C1 GTEx DepMap Descartes 2.01 124.83


Dowload full table

UMAP plots showing activity of gene expression program identified in GEP 8. Cell Cycle (G2-M):

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
FAN_EMBRYONIC_CTX_NSC_2 4.12e-90 Inf 892.07 2.76e-87 2.76e-87
50UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, TUBB4B, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, ARL6IP1, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, GAS2L3, TTK, ECT2, CKAP2L, TROAP, CKS1B, CEP55, CKS2, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1, KIFC1
 233
ZHONG_PFC_C1_OPC 1.33e-89 Inf 838.21 4.46e-87 8.91e-87
50UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, TUBB4B, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, ARL6IP1, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, GAS2L3, TTK, ECT2, CKAP2L, TROAP, CKS1B, CEP55, CKS2, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1, KIFC1
 238
FAN_EMBRYONIC_CTX_MICROGLIA_1 1.39e-83 1020.80 392.67 3.11e-81 9.34e-81
45UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, DLGAP5, MKI67, TUBB4B, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, ARL6IP1, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, CKAP2L, TROAP, CKS1B, CEP55, CKS2, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1
 155
ZHONG_PFC_C2_UNKNOWN_NPC 1.38e-64 550.11 277.07 2.32e-62 9.28e-62
33UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, CDC20, CCNB2, KPNA2, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, TUBB4B, CENPE, GTSE1, CCNA2, CDCA8, ARL6IP1, KIF20A, KNSTRN, AURKA, KIF2C, TTK, CKAP2L, TROAP, CKS2, ARHGAP11A, CDCA3, NDC80
 76
ZHONG_PFC_C8_ORG_PROLIFERATING 6.06e-52 411.59 207.19 5.08e-50 4.06e-49
27CENPF, CCNB1, TPX2, PTTG1, PLK1, ASPM, CENPA, CDC20, CCNB2, NUSAP1, CDKN3, NEK2, TUBB4B, CENPE, BIRC5, CDCA8, ARL6IP1, KIF20A, KNSTRN, AURKA, CKAP2, GAS2L3, TROAP, CKS2, CDCA3, BUB1, PRC1
 62
ZHONG_PFC_C3_UNKNOWN_INP 5.95e-35 346.74 158.69 2.66e-33 3.99e-32
18UBE2C, CENPF, TPX2, NUF2, CCNB2, KPNA2, DLGAP5, CENPE, BIRC5, CCNA2, CDCA8, KIF23, ECT2, CKAP2L, NDC80, CDK1, BUB1, PRC1
 38
ZHONG_PFC_MAJOR_TYPES_NPCS 6.38e-54 221.65 115.92 6.12e-52 4.28e-51
33UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, ASPM, NUF2, CDC20, CCNB2, KPNA2, NUSAP1, CDKN3, DLGAP5, MKI67, TUBB4B, GTSE1, HMGB2, BIRC5, CCNA2, KNSTRN, KIF23, KIF2C, CKAP2, PBK, CKAP2L, CKS1B, CKS2, CDCA3, NDC80, CDK1, BUB1, PRC1
 142
MANNO_MIDBRAIN_NEUROTYPES_HPROGBP 3.15e-57 191.98 93.11 4.23e-55 2.12e-54
40UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CCNB2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, ECT2, CKAP2L, TROAP, CKS1B, CKS2, ARHGAP11A, CDCA3, CDK1, BUB1, PRC1
 300
MANNO_MIDBRAIN_NEUROTYPES_HPROGFPM 2.29e-56 180.43 85.70 2.56e-54 1.54e-53
41UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, ECT2, CKAP2L, TROAP, CKS1B, CKS2, ARHGAP11A, CDCA3, CDK1, BUB1, PRC1
 356
MANNO_MIDBRAIN_NEUROTYPES_HPROGFPL 1.56e-51 139.04 70.21 1.16e-49 1.05e-48
38UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CCNB2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, ECT2, CKAP2L, TROAP, CKS1B, CDCA3, CDK1, BUB1, PRC1
 323
GAO_LARGE_INTESTINE_ADULT_CH_MKI67HIGH_CELLS 1.52e-35 126.27 66.43 7.48e-34 1.02e-32
23CENPF, TOP2A, TPX2, NUF2, CENPA, HMMR, MKI67, GTSE1, BIRC5, CCNA2, CDCA8, KIF20A, KIF23, KIF2C, PBK, CKAP2L, TROAP, CEP55, ARHGAP11A, CDCA3, NDC80, BUB1, KIFC1
 107
TRAVAGLINI_LUNG_PROLIFERATING_BASAL_CELL 3.63e-50 170.67 62.06 2.43e-48 2.43e-47
46UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, CENPE, GTSE1, HMGB2, BIRC5, CCNA2, ARL6IP1, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, ECT2, CKAP2L, TROAP, CKS1B, CEP55, CKS2, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1, KIFC1
 891
TRAVAGLINI_LUNG_PROLIFERATING_NK_T_CELL 1.56e-35 109.42 58.19 7.48e-34 1.05e-32
24UBE2C, CENPF, TOP2A, TPX2, ASPM, NUF2, CDC20, HMMR, CDKN3, MKI67, TUBB4B, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, KIF2C, TROAP, CKS1B, CKS2, CDCA3, NDC80, CDK1
 129
ZHONG_PFC_C1_MICROGLIA 8.80e-43 98.49 52.91 4.92e-41 5.91e-40
32UBE2C, CENPF, CCNB1, TOP2A, TPX2, PLK1, ASPM, NUF2, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, GTSE1, HMGB2, BIRC5, CCNA2, CDCA8, AURKA, KIF23, KIF2C, CKAP2, PBK, CKAP2L, TROAP, CKS1B, CKS2, CDCA3, NDC80, CDK1, BUB1, PRC1
 257
GAO_LARGE_INTESTINE_24W_C2_MKI67POS_PROGENITOR 7.06e-31 97.90 51.16 2.79e-29 4.74e-28
21UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, ASPM, NUF2, CDC20, CCNB2, NUSAP1, CDKN3, DLGAP5, MKI67, BIRC5, CCNA2, KNSTRN, TROAP, NDC80, CDK1, PRC1
 113
TRAVAGLINI_LUNG_PROLIFERATING_MACROPHAGE_CELL 1.74e-44 99.46 42.10 1.06e-42 1.16e-41
44UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, DLGAP5, MKI67, TUBB4B, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, ARL6IP1, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, CKAP2L, TROAP, CKS1B, CEP55, CKS2, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1, KIFC1
 968
MANNO_MIDBRAIN_NEUROTYPES_HNPROG 7.62e-33 66.67 36.15 3.19e-31 5.11e-30
26UBE2C, CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CCNB2, NUSAP1, NEK2, DLGAP5, MKI67, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, KIF23, KIF2C, PBK, CKAP2L, ARHGAP11A, CDCA3, CDK1, PRC1
 229
MANNO_MIDBRAIN_NEUROTYPES_HPROGM 4.75e-23 34.44 18.54 1.77e-21 3.19e-20
22CENPF, TOP2A, PLK1, NUF2, CCNB2, HMMR, NUSAP1, CDKN3, CENPE, GTSE1, HMGB2, BIRC5, CDCA8, PBK, TTK, CKAP2L, TROAP, CKS1B, CDCA3, CDK1, BUB1, PRC1
 307
HAY_BONE_MARROW_PRO_B 1.29e-21 31.98 17.12 4.57e-20 8.67e-19
21UBE2C, CENPF, TOP2A, TPX2, ASPM, NUF2, CENPA, KPNA2, NUSAP1, MKI67, GTSE1, HMGB2, BIRC5, KIF14, CDCA8, ARL6IP1, CKAP2L, CKS1B, CEP55, NDC80, KIFC1
 304
BUSSLINGER_ESOPHAGEAL_EARLY_SUPRABASAL_CELLS 1.87e-11 39.13 16.10 5.71e-10 1.26e-08
9CENPF, CCNB1, TOP2A, PTTG1, ASPM, MKI67, HMGB2, CDK1, PRC1
 79

Dowload full table

mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_G2M_CHECKPOINT 2.80e-42 110.08 59.17 1.40e-40 1.40e-40
30UBE2C, CENPF, TOP2A, TPX2, PTTG1, PLK1, CENPA, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, MKI67, CENPE, BIRC5, CCNA2, AURKA, KIF23, KIF2C, PBK, TTK, TROAP, CKS1B, CKS2, NDC80, CDK1, BUB1, PRC1
 200
HALLMARK_E2F_TARGETS 9.71e-24 46.27 24.41 2.43e-22 4.86e-22
20TOP2A, PTTG1, PLK1, CDC20, CCNB2, KPNA2, HMMR, CDKN3, DLGAP5, MKI67, CENPE, HMGB2, BIRC5, CDCA8, AURKA, KIF2C, CKS1B, CKS2, CDCA3, CDK1
 200
HALLMARK_MITOTIC_SPINDLE 3.95e-22 42.54 22.26 6.58e-21 1.97e-20
19CENPF, TOP2A, TPX2, PLK1, CCNB2, NUSAP1, NEK2, DLGAP5, CENPE, BIRC5, AURKA, KIF23, KIF2C, TTK, ECT2, NDC80, CDK1, BUB1, PRC1
 199
HALLMARK_SPERMATOGENESIS 4.93e-08 18.74 7.45 6.16e-07 2.46e-06
8CCNB2, CDKN3, NEK2, AURKA, KIF2C, TTK, CDK1, BUB1
 135
HALLMARK_GLYCOLYSIS 1.08e-03 7.12 2.18 1.08e-02 5.40e-02
5CENPA, HMMR, KIF20A, AURKA, CDK1
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 4.35e-02 4.05 0.80 2.72e-01 1.00e+00
3TOP2A, CDC20, KIF20A
 200
HALLMARK_MTORC1_SIGNALING 4.35e-02 4.05 0.80 2.72e-01 1.00e+00
3PLK1, AURKA, BUB1
 200
HALLMARK_MYC_TARGETS_V1 4.35e-02 4.05 0.80 2.72e-01 1.00e+00
3CDC20, KPNA2, CCNA2
 200
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 7.33e-01 1.00e+00
2TOP2A, HMGB2
 161
HALLMARK_MYC_TARGETS_V2 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1PLK1
 58
HALLMARK_PEROXISOME 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1TOP2A
 104
HALLMARK_PI3K_AKT_MTOR_SIGNALING 3.41e-01 2.45 0.06 1.00e+00 1.00e+00
1CDK1
 105
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 3.62e-01 2.28 0.06 1.00e+00 1.00e+00
1CKS1B
 113
HALLMARK_DNA_REPAIR 4.49e-01 1.71 0.04 1.00e+00 1.00e+00
1ARL6IP1
 150
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 87

Dowload full table

KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_CELL_CYCLE 1.18e-09 23.63 9.87 2.19e-07 2.19e-07
9CCNB1, PTTG1, PLK1, CDC20, CCNB2, CCNA2, TTK, CDK1, BUB1
 125
KEGG_OOCYTE_MEIOSIS 1.23e-08 22.64 8.97 1.15e-06 2.29e-06
8CCNB1, PTTG1, PLK1, CDC20, CCNB2, AURKA, CDK1, BUB1
 113
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 9.73e-07 21.55 7.30 6.03e-05 1.81e-04
6CCNB1, PLK1, CCNB2, CCNA2, CDK1, BUB1
 85
KEGG_P53_SIGNALING_PATHWAY 1.47e-04 16.96 4.31 6.86e-03 2.74e-02
4CCNB1, CCNB2, GTSE1, CDK1
 68
KEGG_GAP_JUNCTION 4.93e-02 5.92 0.69 1.00e+00 1.00e+00
2TUBB4B, CDK1
 90
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 9.90e-02 3.92 0.46 1.00e+00 1.00e+00
2UBE2C, CDC20
 135
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2BIRC5, CKS1B
 325
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1TUBB4B
 56
KEGG_COLORECTAL_CANCER 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1BIRC5
 62
KEGG_ECM_RECEPTOR_INTERACTION 2.84e-01 3.07 0.08 1.00e+00 1.00e+00
1HMMR
 84
KEGG_SMALL_CELL_LUNG_CANCER 2.84e-01 3.07 0.08 1.00e+00 1.00e+00
1CKS1B
 84
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_GLYCEROLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 49
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 25
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 77
KEGG_ETHER_LIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 33

Dowload full table

CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr14q22 4.93e-02 5.92 0.69 1.00e+00 1.00e+00
2CDKN3, DLGAP5
 90
chr1p34 9.17e-02 2.93 0.58 1.00e+00 1.00e+00
3CDC20, CDCA8, KIF2C
 275
chr15q15 1.09e-01 3.69 0.43 1.00e+00 1.00e+00
2NUSAP1, KNSTRN
 143
chr16p12 1.36e-01 3.21 0.38 1.00e+00 1.00e+00
2PLK1, ARL6IP1
 164
chr1q32 2.78e-01 1.97 0.23 1.00e+00 1.00e+00
2NEK2, KIF14
 266
chr4q27 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1CCNA2
 29
chr5q34 1.41e-01 6.89 0.17 1.00e+00 1.00e+00
1HMMR
 38
chr20q13 6.68e-01 1.31 0.15 1.00e+00 1.00e+00
2UBE2C, AURKA
 400
chr4q24 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1CENPE
 56
chr2q13 2.09e-01 4.40 0.11 1.00e+00 1.00e+00
1BUB1
 59
chr15q23 2.28e-01 3.99 0.10 1.00e+00 1.00e+00
1KIF23
 65
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1ASPM
 71
chr15q13 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1ARHGAP11A
 87
chr1q41 3.06e-01 2.80 0.07 1.00e+00 1.00e+00
1CENPF
 92
chr6q14 3.09e-01 2.77 0.07 1.00e+00 1.00e+00
1TTK
 93
chr17q24 3.12e-01 2.74 0.07 1.00e+00 1.00e+00
1KPNA2
 94
chr5q33 3.52e-01 2.36 0.06 1.00e+00 1.00e+00
1PTTG1
 109
chr10q21 3.69e-01 2.22 0.05 1.00e+00 1.00e+00
1CDK1
 116
chr15q22 3.89e-01 2.07 0.05 1.00e+00 1.00e+00
1CCNB2
 124
chr8p21 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1PBK
 128

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HSD17B8_TARGET_GENES 1.70e-43 80.84 39.52 1.93e-40 1.93e-40
40UBE2C, CENPF, TOP2A, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, KPNA2, HMMR, CDKN3, NEK2, DLGAP5, MKI67, CENPE, GTSE1, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, KIF20A, KIF23, KIF2C, PBK, TTK, ECT2, CKAP2L, TROAP, CKS1B, CEP55, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1, KIFC1
 659
BARX2_TARGET_GENES 9.93e-15 10.21 5.61 5.63e-12 1.13e-11
29UBE2C, CENPF, CCNB1, TOP2A, TPX2, ASPM, CENPA, CDC20, CCNB2, KPNA2, NEK2, DLGAP5, TUBB4B, HMGB2, KIF14, CDCA8, ARL6IP1, KIF23, KIF2C, CKAP2, ECT2, TROAP, CKS1B, CKS2, CDCA3, CDK1, BUB1, PRC1, KIFC1
 1723
ASH1L_TARGET_GENES 1.23e-10 7.49 4.09 4.64e-08 1.39e-07
23CENPF, CCNB1, TOP2A, TPX2, ASPM, CENPA, CCNB2, KPNA2, HMMR, CDKN3, DLGAP5, TUBB4B, CENPE, CDCA8, AURKA, CKAP2, ECT2, CKAP2L, CKS1B, CKS2, CDCA3, CDK1, BUB1
 1446
BARX1_TARGET_GENES 6.64e-10 7.29 3.94 1.88e-07 7.52e-07
21UBE2C, CENPF, TOP2A, TPX2, PLK1, NUF2, CENPA, CDC20, KPNA2, CDKN3, NEK2, DLGAP5, CENPE, HMGB2, CDCA8, ARL6IP1, CKS1B, CKS2, ARHGAP11A, NDC80, KIFC1
 1264
NFY_Q6 7.21e-06 9.34 3.75 1.02e-03 8.17e-03
8CENPF, TOP2A, NEK2, HMGB2, TTK, CKS2, CDK1, BUB1
 263
E2F5_TARGET_GENES 2.08e-07 5.61 2.96 4.72e-05 2.36e-04
18CENPF, TOP2A, TPX2, PLK1, NUF2, CENPA, CCNB2, CDKN3, DLGAP5, MKI67, HMGB2, BIRC5, CCNA2, CDCA8, KNSTRN, PBK, CDCA3, NDC80
 1273
CC2D1A_TARGET_GENES 8.67e-07 5.25 2.73 1.64e-04 9.82e-04
17CENPF, PTTG1, PLK1, ASPM, NUF2, CDC20, CENPE, HMGB2, KIF14, CCNA2, ARL6IP1, AURKA, PBK, ECT2, CDK1, BUB1, PRC1
 1245
GATTGGY_NFY_Q6_01 2.30e-06 5.07 2.61 3.73e-04 2.61e-03
16UBE2C, CENPF, TOP2A, TPX2, PLK1, CDKN3, HMGB2, KIF20A, AURKA, KIF23, TROAP, CKS1B, CKS2, ARHGAP11A, CDK1, BUB1
 1177
ALPHACP1_01 5.27e-04 6.63 2.29 5.97e-02 5.97e-01
6UBE2C, ASPM, NEK2, DLGAP5, CKS2, CDCA3
 263
CHAMP1_TARGET_GENES 1.28e-03 6.84 2.10 1.12e-01 1.00e+00
5CENPF, NUF2, CENPE, CCNA2, BUB1
 208
NFY_C 2.83e-03 5.67 1.74 2.29e-01 1.00e+00
5UBE2C, ARL6IP1, KIF20A, KIF23, CKS2
 250
NFY_01 3.39e-03 5.43 1.67 2.56e-01 1.00e+00
5PLK1, NEK2, KIF23, CKS2, CDK1
 261
E2F2_TARGET_GENES 4.84e-04 3.32 1.65 5.97e-02 5.48e-01
14CENPF, CCNB1, TOP2A, TPX2, NUF2, CENPA, CENPE, HMGB2, CCNA2, ARL6IP1, KIF20A, CKAP2, CDK1, KIFC1
 1481
CEBPZ_TARGET_GENES 6.12e-04 3.23 1.61 6.31e-02 6.94e-01
14UBE2C, TOP2A, NUF2, CENPA, CDKN3, DLGAP5, TUBB4B, CCNA2, CDCA8, AURKA, CKAP2L, TROAP, CKS1B, CDCA3
 1520
AEBP2_TARGET_GENES 1.11e-03 3.45 1.59 1.05e-01 1.00e+00
11UBE2C, CENPF, CCNB1, TOP2A, TPX2, CENPA, TUBB4B, CENPE, CKS1B, CDCA3, CDK1
 1033
MYBL1_TARGET_GENES 7.71e-03 5.55 1.44 5.14e-01 1.00e+00
4CENPF, PBK, CDCA3, KIFC1
 200
ZNF548_TARGET_GENES 1.37e-02 12.10 1.38 7.40e-01 1.00e+00
2CDKN3, KNSTRN
 45
ZFHX3_TARGET_GENES 1.02e-02 2.38 1.16 6.07e-01 1.00e+00
13UBE2C, CCNB1, TOP2A, NUF2, CENPA, CCNB2, HMMR, NUSAP1, CENPE, AURKA, KIF2C, PBK, CKS1B
 1857
ZNF350_TARGET_GENES 1.69e-02 2.42 1.11 8.22e-01 1.00e+00
11CENPF, TOP2A, PTTG1, PLK1, NUF2, CENPA, HMGB2, TROAP, CKS1B, CDK1, PRC1
 1470
PRKDC_TARGET_GENES 1.48e-02 2.75 1.11 7.60e-01 1.00e+00
8UBE2C, TOP2A, CENPA, CCNB2, DLGAP5, TUBB4B, CDCA3, PRC1
 875

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION 2.76e-27 63.22 33.44 2.95e-24 2.06e-23
21UBE2C, CENPF, CCNB1, PTTG1, PLK1, NUF2, CDC20, NUSAP1, NEK2, DLGAP5, CENPE, KIF14, CDCA8, KNSTRN, KIF23, KIF2C, TTK, NDC80, BUB1, PRC1, KIFC1
 164
GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE 7.49e-13 87.68 32.55 1.87e-10 5.61e-09
8CCNB1, NUF2, NEK2, CENPE, KNSTRN, KIF2C, ECT2, NDC80
 35
GOBP_KINETOCHORE_ORGANIZATION 2.06e-10 105.76 32.40 3.86e-08 1.54e-06
6CENPF, NUF2, CENPA, DLGAP5, CENPE, NDC80
 22
GOBP_SISTER_CHROMATID_SEGREGATION 3.35e-27 55.45 29.60 3.13e-24 2.50e-23
22UBE2C, CENPF, CCNB1, TOP2A, PTTG1, PLK1, NUF2, CDC20, NUSAP1, NEK2, DLGAP5, CENPE, KIF14, CDCA8, KNSTRN, KIF23, KIF2C, TTK, NDC80, BUB1, PRC1, KIFC1
 199
GOBP_MITOTIC_NUCLEAR_ENVELOPE_DISASSEMBLY 1.07e-07 135.51 28.72 1.34e-05 8.03e-04
4CCNB1, PLK1, CCNB2, CDK1
 12
GOBP_CELL_DIVISION 5.35e-36 51.70 27.31 4.00e-32 4.00e-32
35UBE2C, CENPF, CCNB1, TOP2A, TPX2, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, NUSAP1, NEK2, CENPE, BIRC5, KIF14, CCNA2, CDCA8, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, ECT2, CKS1B, CEP55, CKS2, CDCA3, NDC80, CDK1, BUB1, PRC1, KIFC1
 600
GOBP_MITOTIC_NUCLEAR_DIVISION 6.57e-30 50.17 27.28 9.83e-27 4.91e-26
26UBE2C, CENPF, CCNB1, TPX2, PTTG1, PLK1, NUF2, CDC20, CCNB2, NUSAP1, NEK2, DLGAP5, MKI67, CENPE, KIF14, CDCA8, KNSTRN, AURKA, KIF23, KIF2C, TTK, NDC80, CDK1, BUB1, PRC1, KIFC1
 296
GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION 1.21e-17 57.64 27.02 5.03e-15 9.06e-14
13UBE2C, CENPF, CCNB1, PTTG1, PLK1, CDC20, DLGAP5, MKI67, CENPE, KIF2C, TTK, NDC80, BUB1
 89
GOBP_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE 1.55e-07 120.21 26.08 1.90e-05 1.16e-03
4CCNB1, NEK2, KNSTRN, ECT2
 13
GOBP_REGULATION_OF_CHROMOSOME_SEPARATION 2.50e-15 58.60 25.84 8.13e-13 1.87e-11
11UBE2C, CENPF, CCNB1, PTTG1, PLK1, CDC20, DLGAP5, CENPE, TTK, NDC80, BUB1
 71
GOBP_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE 4.76e-14 57.71 24.47 1.42e-11 3.56e-10
10UBE2C, CENPF, CCNB1, PLK1, CDC20, DLGAP5, CENPE, TTK, NDC80, BUB1
 64
GOBP_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEGREGATION 6.62e-12 64.16 24.33 1.55e-09 4.95e-08
8CENPF, CCNB1, PTTG1, PLK1, CDC20, TTK, NDC80, BUB1
 45
GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS 1.02e-19 46.27 23.24 6.33e-17 7.60e-16
16CCNB1, TPX2, PLK1, NUF2, CENPA, CDC20, NUSAP1, NEK2, DLGAP5, CENPE, AURKA, KIF23, TTK, NDC80, PRC1, KIFC1
 143
GOBP_NUCLEAR_CHROMOSOME_SEGREGATION 9.02e-26 42.60 22.99 6.75e-23 6.75e-22
23UBE2C, CENPF, CCNB1, TOP2A, PTTG1, PLK1, NUF2, CDC20, NUSAP1, NEK2, DLGAP5, CENPE, KIF14, CDCA8, KNSTRN, KIF23, KIF2C, TTK, ECT2, NDC80, BUB1, PRC1, KIFC1
 273
GOBP_MITOTIC_SPINDLE_ORGANIZATION 1.19e-17 46.62 22.54 5.03e-15 8.90e-14
14CCNB1, TPX2, PLK1, NUF2, CDC20, NEK2, DLGAP5, CENPE, AURKA, KIF23, TTK, NDC80, PRC1, KIFC1
 118
GOBP_MITOTIC_CELL_CYCLE 1.88e-34 44.73 22.39 7.05e-31 1.41e-30
39UBE2C, CENPF, CCNB1, TPX2, PTTG1, PLK1, NUF2, CENPA, CDC20, CCNB2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, TUBB4B, CENPE, GTSE1, KIF14, CCNA2, CDCA8, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, ECT2, CKS1B, CEP55, CKS2, NDC80, CDK1, BUB1, PRC1, KIFC1
 1032
GOBP_MEMBRANE_DISASSEMBLY 2.93e-07 98.26 22.02 3.43e-05 2.19e-03
4CCNB1, PLK1, CCNB2, CDK1
 15
GOBP_ATTACHMENT_OF_MITOTIC_SPINDLE_MICROTUBULES_TO_KINETOCHORE 2.93e-07 98.26 22.02 3.43e-05 2.19e-03
4NUF2, CENPE, KIF2C, NDC80
 15
GOBP_CHROMOSOME_SEGREGATION 7.89e-27 40.05 21.81 6.56e-24 5.90e-23
25UBE2C, CENPF, CCNB1, TOP2A, PTTG1, PLK1, NUF2, CDC20, NUSAP1, NEK2, DLGAP5, MKI67, CENPE, BIRC5, KIF14, CDCA8, KNSTRN, KIF23, KIF2C, TTK, ECT2, NDC80, BUB1, PRC1, KIFC1
 337
GOBP_CHROMOSOME_SEPARATION 1.52e-15 47.45 21.79 5.16e-13 1.14e-11
12UBE2C, CENPF, CCNB1, TOP2A, PTTG1, PLK1, CDC20, DLGAP5, CENPE, TTK, NDC80, BUB1
 95

Dowload full table

Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE15750_DAY6_VS_DAY10_EFF_CD8_TCELL_UP 5.76e-53 175.99 91.82 2.81e-49 2.81e-49
35UBE2C, TOP2A, TPX2, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, CENPE, GTSE1, BIRC5, CDCA8, KIF20A, KNSTRN, AURKA, KIF23, KIF2C, CKAP2, PBK, TTK, CKAP2L, CKS1B, CEP55, CKS2, ARHGAP11A, NDC80, CDK1, BUB1, PRC1
 200
GSE15750_DAY6_VS_DAY10_TRAF6KO_EFF_CD8_TCELL_UP 9.53e-51 159.42 84.06 2.32e-47 4.64e-47
34UBE2C, CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CENPA, CCNB2, HMMR, CDKN3, NEK2, MKI67, TUBB4B, CENPE, GTSE1, HMGB2, BIRC5, CCNA2, KIF20A, KNSTRN, AURKA, KIF23, CKAP2, PBK, TTK, ECT2, CKAP2L, CKS1B, CEP55, ARHGAP11A, CDCA3, CDK1, BUB1
 200
GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP 2.67e-45 130.53 69.80 4.34e-42 1.30e-41
31CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CCNB2, HMMR, CDKN3, DLGAP5, MKI67, CENPE, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, AURKA, KIF23, CKAP2, PBK, TTK, ECT2, CKS1B, CEP55, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1
 187
GSE14415_NATURAL_TREG_VS_TCONV_DN 9.78e-44 124.40 66.75 1.19e-40 4.77e-40
30CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CCNB2, HMMR, CDKN3, DLGAP5, CENPE, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, AURKA, KIF23, CKAP2, PBK, TTK, CKAP2L, CKS1B, CEP55, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1
 180
GSE13547_2H_VS_12_H_ANTI_IGM_STIM_BCELL_UP 5.47e-40 108.04 58.11 5.33e-37 2.66e-36
28CENPF, TOP2A, TPX2, PTTG1, ASPM, NUF2, CDC20, CCNB2, HMMR, CDKN3, MKI67, CENPE, HMGB2, BIRC5, KIF14, CCNA2, CDCA8, PBK, TTK, CKAP2L, CKS1B, CEP55, ARHGAP11A, CDCA3, NDC80, CDK1, BUB1, PRC1
 175
GSE14415_INDUCED_VS_NATURAL_TREG_DN 1.49e-39 103.83 55.82 1.21e-36 7.24e-36
28CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CENPA, CCNB2, KPNA2, HMMR, DLGAP5, MKI67, BIRC5, KIF14, CCNA2, CDCA8, KIF23, KIF2C, PBK, TTK, ECT2, CKAP2L, CKS1B, CEP55, ARHGAP11A, CDCA3, CDK1, BUB1
 181
GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_DN 1.22e-36 87.24 47.12 8.47e-34 5.93e-33
27UBE2C, CENPF, CCNB1, TPX2, PTTG1, PLK1, ASPM, NUF2, CENPA, CDC20, CCNB2, HMMR, CDKN3, NEK2, DLGAP5, MKI67, CENPE, BIRC5, CDCA8, KIF20A, AURKA, PBK, TROAP, CEP55, CDCA3, CDK1, PRC1
 195
GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_YOUNG_DN 2.48e-36 84.74 45.75 1.35e-33 1.21e-32
27UBE2C, CCNB1, TOP2A, PTTG1, ASPM, CENPA, CDC20, CCNB2, HMMR, NUSAP1, CDKN3, DLGAP5, MKI67, CENPE, BIRC5, CDCA8, KIF20A, AURKA, KIF2C, PBK, TTK, CKS1B, CEP55, CKS2, CDCA3, BUB1, KIFC1
 200
GSE39556_CD8A_DC_VS_NK_CELL_MOUSE_3H_POST_POLYIC_INJ_UP 2.48e-36 84.74 45.75 1.35e-33 1.21e-32
27CCNB1, TOP2A, TPX2, CENPA, CDC20, CCNB2, KPNA2, HMMR, CDKN3, NEK2, DLGAP5, TUBB4B, CENPE, GTSE1, KIF14, CCNA2, AURKA, KIF23, KIF2C, TTK, TROAP, CKS1B, CKS2, ARHGAP11A, NDC80, CDK1, BUB1
 200
GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP 1.29e-33 79.49 42.82 5.25e-31 6.31e-30
25CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CENPA, CCNB2, KPNA2, HMMR, CDKN3, MKI67, CENPE, KIF14, CCNA2, CDCA8, KIF2C, CKAP2, TTK, ECT2, CKS1B, CDCA3, CDK1, BUB1, PRC1
 182
GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_UP 2.01e-34 77.75 42.05 8.92e-32 9.81e-31
26TOP2A, ASPM, CENPA, CDC20, CCNB2, KPNA2, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, BIRC5, CCNA2, CDCA8, KIF20A, AURKA, KIF23, KIF2C, TTK, ECT2, CKS1B, CKS2, CDCA3, CDK1, BUB1, PRC1
 200
GSE30962_PRIMARY_VS_SECONDARY_ACUTE_LCMV_INF_CD8_TCELL_UP 2.01e-34 77.75 42.05 8.92e-32 9.81e-31
26CENPF, TOP2A, ASPM, NUF2, CENPA, CCNB2, KPNA2, NUSAP1, NEK2, DLGAP5, TUBB4B, CENPE, HMGB2, BIRC5, CCNA2, KIF20A, KIF23, TTK, CKAP2L, CKS1B, CEP55, CKS2, ARHGAP11A, CDCA3, NDC80, BUB1
 200
GSE2405_S_AUREUS_VS_UNTREATED_NEUTROPHIL_DN 1.32e-32 71.89 38.68 4.88e-30 6.42e-29
25CENPF, TOP2A, TPX2, NUF2, CENPA, KPNA2, HMMR, NUSAP1, CDKN3, MKI67, CENPE, BIRC5, CCNA2, CDCA8, KIF20A, KNSTRN, AURKA, KIF2C, CKAP2, PBK, CKAP2L, CEP55, CDCA3, NDC80, PRC1
 199
GSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_UP 1.50e-32 71.50 38.46 4.88e-30 7.31e-29
25UBE2C, CENPF, CCNB1, TPX2, PTTG1, PLK1, ASPM, CENPA, CDC20, CCNB2, HMMR, NUSAP1, DLGAP5, CENPE, HMGB2, CCNA2, CDCA8, KIF20A, AURKA, KIF2C, CEP55, CKS2, NDC80, CDK1, PRC1
 200
GSE39110_DAY3_VS_DAY6_POST_IMMUNIZATION_CD8_TCELL_DN 1.50e-32 71.50 38.46 4.88e-30 7.31e-29
25UBE2C, CENPF, TOP2A, TPX2, PLK1, ASPM, NUF2, CDC20, CCNB2, KPNA2, NUSAP1, NEK2, CENPE, BIRC5, CCNA2, KIF20A, AURKA, KIF2C, CKAP2, PBK, TTK, CKS1B, CEP55, CDK1, BUB1
 200
GOLDRATH_NAIVE_VS_EFF_CD8_TCELL_DN 1.03e-30 65.45 35.28 3.13e-28 5.01e-27
24TOP2A, ASPM, CENPA, CCNB2, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, BIRC5, CCNA2, CDCA8, KIF20A, AURKA, KIF2C, TTK, ECT2, CKS1B, CKS2, CDCA3, CDK1, BUB1, PRC1, KIFC1
 200
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_UP 6.48e-29 60.11 32.23 1.86e-26 3.15e-25
23UBE2C, CENPF, CCNB1, TPX2, PTTG1, CENPA, CDC20, CCNB2, NUSAP1, CDKN3, DLGAP5, TUBB4B, CENPE, BIRC5, CCNA2, CDCA8, AURKA, KIF2C, CKS1B, CEP55, CKS2, BUB1, PRC1
 200
GSE25088_WT_VS_STAT6_KO_MACROPHAGE_IL4_STIM_DN 2.99e-27 55.77 29.76 8.09e-25 1.46e-23
22CENPF, CCNB1, TOP2A, PTTG1, ASPM, CDC20, CCNB2, KPNA2, HMMR, NUSAP1, CDKN3, NEK2, DLGAP5, MKI67, HMGB2, KIF14, KIF20A, AURKA, TROAP, CEP55, CDK1, PRC1
 198
GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_DN 3.75e-27 55.14 29.44 9.61e-25 1.83e-23
22UBE2C, CCNB1, TOP2A, TPX2, ASPM, CENPA, CDC20, CCNB2, HMMR, NUSAP1, CDKN3, MKI67, CENPE, BIRC5, CDCA8, KIF20A, KIF23, KIF2C, CKS1B, CEP55, CKS2, CDCA3
 200
GSE40274_CTRL_VS_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP 7.18e-25 53.37 28.08 1.67e-22 3.50e-21
20TOP2A, TPX2, NUF2, HMMR, DLGAP5, MKI67, GTSE1, BIRC5, KIF14, CCNA2, CDCA8, KIF23, TTK, ECT2, CKAP2L, CDCA3, NDC80, CDK1, BUB1, PRC1
 176

Dowload full table

Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
TOP2A 4 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA topoisomerase. Binds DNA in the crystal structure (PDB: 4FM9).
PTTG1 6 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation has no evidence for DNA-binding activity (PMID:9811450), only transcriptional activation in reporter experiments
CENPA 10 Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone like protein. Binds DNA in the crystal structure (PDB: 3AN2).
HMGB2 23 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB½ are non-sequence-specific binding proteins (PMID: 11497996). HMGB2 is well-known to facilitate DNA-bending and interact with sequence-specific TFs and transcriptional co-factors.
NDC80 46 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
NUCKS1 52 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a GRP core, which is similar to an AT-hook. But, the amino acids flanking the core are quite different from an AT-hook. Could non-specifically bind to DNA, but lacks compelling evidence.
RAD21 67 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Motifs are suspicious; protein is a component of the cohesin complex and there is no evidence for direct binding to DNA.
HMGB1 71 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB½ are non-sequence-specific binding proteins (PMID: 11497996).
SFPQ 75 No ssDNA/RNA binding Not a DNA binding protein No motif None Splicing factor - contains 2 RRM domains
MXD3 81 Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).
FOXM1 93 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
HMGB3 106 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Similar to HMGB½, which bind DNA with low specificity
HP1BP3 113 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone H1-like protein. Binds in ChIP experiments (PMID: 27425409) and binds DNA (likely non-specifically) with HP1.
KIF15 117 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has a bZIP like fragment that lacks the basic region required for DNA binding and a STE-domain that is classified as a potential DBD in CIS-BP. It is a kinesin operating in the microtubule system (PMID: 24419385)
MIS18BP1 120 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 1 SANT domain, and a SANTA domain
MYEF2 127 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single-stranded DNA and can regulate transcription in transfection reporter assays
DEPDC1B 132 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein does not have known DBDs and has been shown to function as an inhibitor of a RhoA-based signaling complex (PMID: 25458010)
FOXN4 135 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
UBB 161 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
EZH2 178 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is a classic polycomb protein with no evidence of sequence specific DNA binding after years of intense study. I dont see anything in (PMID :15520282) that supports DNA binding.


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T214_CTCAGTCCAACCGCCA-1 Neurons:adrenal_medulla_cell_line 0.24 1001.74
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_2lox-22: 0.34, Embryonic_stem_cells: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34
T214_GCAACATTCTCGCGTT-1 Neurons:adrenal_medulla_cell_line 0.24 885.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_2lox-22: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_2lox-21: 0.33
T214_AAAGGATTCCACTGAA-1 Neurons:adrenal_medulla_cell_line 0.24 849.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.32, Embryonic_stem_cells: 0.32, iPS_cells:PDB_2lox-22: 0.32
T214_GAAGTAACACGTGTGC-1 Neurons:adrenal_medulla_cell_line 0.25 826.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Embryonic_stem_cells: 0.32, iPS_cells:PDB_2lox-22: 0.32
T214_CAGAGCCAGGGTTAGC-1 Neurons:adrenal_medulla_cell_line 0.24 798.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.33, Embryonic_stem_cells: 0.33
T214_GCCAGTGGTGGGTCAA-1 Neurons:adrenal_medulla_cell_line 0.23 771.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-22: 0.33, Embryonic_stem_cells: 0.33
T214_ACTTTGTTCCTTCTAA-1 Neurons:adrenal_medulla_cell_line 0.23 769.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_2lox-17: 0.32
T214_AAGCGTTCAATTGTGC-1 Neurons:adrenal_medulla_cell_line 0.22 757.06
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-17: 0.33, Embryonic_stem_cells: 0.33
T214_CGAATTGTCCAGCTCT-1 Neurons:adrenal_medulla_cell_line 0.24 713.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-21: 0.32
T214_ATGGGAGGTGGCTAGA-1 Neurons:adrenal_medulla_cell_line 0.25 692.01
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-22: 0.33, Embryonic_stem_cells: 0.33
T214_CTACCTGTCTCCCATG-1 Neurons:adrenal_medulla_cell_line 0.23 663.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.33
T188_GGTAACTCACGGTGAA-1 Neurons:adrenal_medulla_cell_line 0.23 658.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32
T230_TTCCACGGTGCCCACA-1 Neurons:adrenal_medulla_cell_line 0.24 654.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_2lox-17: 0.35, Embryonic_stem_cells: 0.35
T230_CATACAGAGAGATCGC-1 Neurons:adrenal_medulla_cell_line 0.22 651.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-22: 0.34, Embryonic_stem_cells: 0.34, iPS_cells:PDB_2lox-21: 0.34
T214_CGAGGCTTCAGCAATC-1 Neurons:adrenal_medulla_cell_line 0.22 640.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-21: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31
T214_TTTCCTCCACGCCACA-1 Neurons:adrenal_medulla_cell_line 0.26 597.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Embryonic_stem_cells: 0.32, iPS_cells:PDB_2lox-22: 0.32
T188_TCAGGGCAGACCGCCT-1 Neurons:adrenal_medulla_cell_line 0.23 593.64
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-22: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.32, Embryonic_stem_cells: 0.32
T214_TTAGGCAGTTGTGGAG-1 Neurons:adrenal_medulla_cell_line 0.24 586.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_2lox-17: 0.35
T188_TTGTTCAGTCCATACA-1 Neurons:adrenal_medulla_cell_line 0.18 557.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_2lox-21: 0.29
T230_TCATTTGCATCAACCA-1 Neurons:adrenal_medulla_cell_line 0.23 542.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_2lox-22: 0.34, Embryonic_stem_cells: 0.33, iPS_cells:PDB_2lox-21: 0.33
T214_CCTACGTGTGGTCTAT-1 Neurons:adrenal_medulla_cell_line 0.22 540.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_2lox-22: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-21: 0.32
T214_ATCGATGTCTCGCGTT-1 Neurons:adrenal_medulla_cell_line 0.23 528.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-21: 0.32
T188_GAGTCTATCGCCTCTA-1 Neurons:adrenal_medulla_cell_line 0.22 519.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-21: 0.32
T230_CCCTGATGTCTACAGT-1 Neurons:adrenal_medulla_cell_line 0.20 517.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_2lox-22: 0.33, Embryonic_stem_cells: 0.33
T230_ATTACTCAGCGTGCTC-1 Neurons:adrenal_medulla_cell_line 0.20 514.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.4, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, iPS_cells:PDB_2lox-22: 0.38, Embryonic_stem_cells: 0.38, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.37, iPS_cells:PDB_2lox-21: 0.37
T214_CCCGAAGCACCAACAT-1 Neurons:adrenal_medulla_cell_line 0.24 510.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-21: 0.31
T230_TCCTTCTAGTCCTGCG-1 Neurons:adrenal_medulla_cell_line 0.24 506.21
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, Neurons:ES_cell-derived_neural_precursor: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-22: 0.35, Embryonic_stem_cells: 0.34, iPS_cells:PDB_2lox-21: 0.34
T200_TTTCAGTTCTTTGCGC-1 Neurons:adrenal_medulla_cell_line 0.22 501.41
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, Embryonic_stem_cells: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_2lox-21: 0.36, iPS_cells:PDB_2lox-17: 0.36
T200_GTGGTTATCATCGCTC-1 Neurons:adrenal_medulla_cell_line 0.21 501.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-21: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_2lox-17: 0.33
T214_GATCATGTCAGACCGC-1 Neurons:adrenal_medulla_cell_line 0.23 489.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-17: 0.32
T200_CCCAACTAGAGGTTAT-1 Neurons:adrenal_medulla_cell_line 0.22 487.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, Embryonic_stem_cells: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-17: 0.34
T188_TCTACATGTCCCGCAA-1 Neurons:adrenal_medulla_cell_line 0.21 473.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, Embryonic_stem_cells: 0.32
T200_TGATTTCGTCTGGTTA-1 Neurons:adrenal_medulla_cell_line 0.21 472.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_2lox-17: 0.35, Embryonic_stem_cells: 0.34
T214_CGTAATGGTACCATAC-1 Neurons:adrenal_medulla_cell_line 0.22 458.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-21: 0.31
T230_AAAGGTAGTGTTGCCG-1 Neurons:adrenal_medulla_cell_line 0.20 454.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, Embryonic_stem_cells: 0.35, iPS_cells:iPS:minicircle-derived: 0.35, iPS_cells:PDB_2lox-21: 0.35
T188_CTCTGGTCACCGTGCA-1 Neurons:adrenal_medulla_cell_line 0.23 453.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_2lox-22: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_2lox-21: 0.3
T230_TATTGCTCAGAGTAAT-1 Neurons:adrenal_medulla_cell_line 0.20 451.91
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, Neurons:ES_cell-derived_neural_precursor: 0.36, Embryonic_stem_cells: 0.36, iPS_cells:PDB_2lox-21: 0.36
T188_GTGTCCTTCTCAAAGC-1 Neurons:adrenal_medulla_cell_line 0.22 447.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.31, Embryonic_stem_cells: 0.31
T214_GTGGTTACAACCGCTG-1 Neurons:adrenal_medulla_cell_line 0.18 446.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-17: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:fibroblast-derived:Retroviral_transf: 0.31, Embryonic_stem_cells: 0.31
T230_TGTTCCGCAAAGGATT-1 Neurons:adrenal_medulla_cell_line 0.20 440.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_2lox-21: 0.36, iPS_cells:PDB_2lox-17: 0.36, Embryonic_stem_cells: 0.35
T214_AGTACTGTCGGACAAG-1 Neurons:adrenal_medulla_cell_line 0.12 439.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, Pro-B_cell_CD34+: 0.31, Embryonic_stem_cells: 0.31
T214_AGCGATTGTGGTAACG-1 Neurons:adrenal_medulla_cell_line 0.19 436.60
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:fibroblast-derived:Retroviral_transf: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31
T214_AGGTTACAGTTGCATC-1 Neurons:adrenal_medulla_cell_line 0.21 433.90
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.32, Embryonic_stem_cells: 0.32
T230_AGTGATCGTCACCGAC-1 Neurons:adrenal_medulla_cell_line 0.21 432.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-17: 0.35, iPS_cells:PDB_2lox-21: 0.35, Embryonic_stem_cells: 0.35
T188_TGAGGTTCAGCGTAGA-1 Neurons:adrenal_medulla_cell_line 0.21 424.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-22: 0.3, Embryonic_stem_cells: 0.29
T230_ACTTCGCAGAAGCTCG-1 Neurons:adrenal_medulla_cell_line 0.20 420.42
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.32, Embryonic_stem_cells: 0.32
T200_CGCATAATCTACCCAC-1 Neurons:adrenal_medulla_cell_line 0.22 417.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_2lox-17: 0.35, iPS_cells:PDB_2lox-21: 0.35, Embryonic_stem_cells: 0.34
T214_TGCTTCGGTGTTATCG-1 Neurons:adrenal_medulla_cell_line 0.23 415.27
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-17: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33
T214_TATCAGGTCGTTGTGA-1 Neurons:adrenal_medulla_cell_line 0.18 413.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-17: 0.34, iPS_cells:PDB_2lox-5: 0.33
T230_GATGACTAGGACAGTC-1 Neurons:adrenal_medulla_cell_line 0.19 413.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Embryonic_stem_cells: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_2lox-21: 0.32


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.75e-04
Mean rank of genes in gene set: 17.75
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
UBE2C 0.0184282 1 GTEx DepMap Descartes 23.13 4368.66
TOP2A 0.0169205 4 GTEx DepMap Descartes 18.45 517.59
MKI67 0.0134630 19 GTEx DepMap Descartes 8.80 114.09
CDK1 0.0105786 47 GTEx DepMap Descartes 4.35 341.08


Proteasomal degradation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this is for proteasomal degradataion:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.77e-03
Mean rank of genes in gene set: 2076.8
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PSMA4 0.0013887 509 GTEx DepMap Descartes 3.37 120.41
PSMC2 0.0005048 1734 GTEx DepMap Descartes 0.87 43.14
PSME2 0.0003821 2231 GTEx DepMap Descartes 1.67 88.76
PSMB3 0.0003356 2469 GTEx DepMap Descartes 4.04 756.54
PSMA3 0.0002000 3441 GTEx DepMap Descartes 1.86 214.47


Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.95e-03
Mean rank of genes in gene set: 98.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MKI67 0.0134630 19 GTEx DepMap Descartes 8.80 114.09
EZH2 0.0033302 178 GTEx DepMap Descartes 1.58 72.45




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.05e-16
Mean rank of genes in gene set: 4591.59
Median rank of genes in gene set: 2967
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
UBE2C 0.0184282 1 GTEx DepMap Descartes 23.13 4368.66
NUF2 0.0151274 9 GTEx DepMap Descartes 4.88 418.67
NUSAP1 0.0143347 15 GTEx DepMap Descartes 6.95 369.90
CDKN3 0.0138217 16 GTEx DepMap Descartes 4.96 794.93
TUBB4B 0.0133196 20 GTEx DepMap Descartes 12.80 1028.45
BIRC5 0.0126678 24 GTEx DepMap Descartes 9.17 535.61
ARL6IP1 0.0119668 28 GTEx DepMap Descartes 10.57 815.71
KNSTRN 0.0118293 30 GTEx DepMap Descartes 3.30 NA
PBK 0.0110718 35 GTEx DepMap Descartes 3.55 302.30
PRC1 0.0098518 49 GTEx DepMap Descartes 3.20 139.28
ENDOG 0.0086194 61 GTEx DepMap Descartes 5.35 810.32
CDKN2C 0.0064634 92 GTEx DepMap Descartes 1.92 118.95
FOXM1 0.0064572 93 GTEx DepMap Descartes 1.80 83.49
UBE2T 0.0062674 98 GTEx DepMap Descartes 5.46 583.41
KIF15 0.0052329 117 GTEx DepMap Descartes 0.94 29.41
MYEF2 0.0049322 127 GTEx DepMap Descartes 3.41 52.88
CCSAP 0.0036661 166 GTEx DepMap Descartes 1.15 NA
H1FX 0.0031827 185 GTEx DepMap Descartes 12.16 NA
NET1 0.0030582 192 GTEx DepMap Descartes 1.01 37.52
CDCA5 0.0030385 194 GTEx DepMap Descartes 1.18 68.43
ANP32A 0.0029897 200 GTEx DepMap Descartes 3.47 143.92
INSM2 0.0028816 213 GTEx DepMap Descartes 1.49 75.37
ATCAY 0.0028147 220 GTEx DepMap Descartes 2.04 66.19
RNFT2 0.0025612 239 GTEx DepMap Descartes 0.52 20.62
MAP1B 0.0024539 253 GTEx DepMap Descartes 18.70 247.42
ASRGL1 0.0021503 293 GTEx DepMap Descartes 1.52 105.29
ATL1 0.0020402 313 GTEx DepMap Descartes 1.14 34.54
LSM4 0.0020183 318 GTEx DepMap Descartes 5.38 465.86
RRM2 0.0019967 324 GTEx DepMap Descartes 1.16 44.81
AKAP12 0.0019603 328 GTEx DepMap Descartes 3.72 66.83


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.60e-01
Mean rank of genes in gene set: 6573.78
Median rank of genes in gene set: 6889
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DESI2 0.0026920 229 GTEx DepMap Descartes 1.03 NA
FAM102B 0.0025756 238 GTEx DepMap Descartes 0.49 9.70
ENAH 0.0025374 243 GTEx DepMap Descartes 3.41 39.03
ANXA2 0.0019276 338 GTEx DepMap Descartes 4.91 206.21
PTN 0.0016221 420 GTEx DepMap Descartes 1.13 123.92
PHTF2 0.0014140 494 GTEx DepMap Descartes 0.50 15.42
FLRT2 0.0014113 497 GTEx DepMap Descartes 0.32 1.43
LAPTM4A 0.0013932 506 GTEx DepMap Descartes 3.27 375.15
ITGAV 0.0013370 530 GTEx DepMap Descartes 0.37 8.10
TUBB6 0.0012755 567 GTEx DepMap Descartes 0.22 21.14
LIX1L 0.0012503 582 GTEx DepMap Descartes 0.56 21.91
SLC38A2 0.0012084 609 GTEx DepMap Descartes 1.76 60.29
CLIC4 0.0011662 637 GTEx DepMap Descartes 0.45 17.46
PCDH18 0.0010412 736 GTEx DepMap Descartes 0.08 2.15
ACTN1 0.0009491 846 GTEx DepMap Descartes 1.00 31.02
SFT2D2 0.0009161 886 GTEx DepMap Descartes 0.42 5.29
LIFR 0.0008906 913 GTEx DepMap Descartes 0.24 3.10
RGS3 0.0008478 966 GTEx DepMap Descartes 0.35 13.40
LRRC8C 0.0007987 1034 GTEx DepMap Descartes 0.18 3.69
TXNDC12 0.0007958 1041 GTEx DepMap Descartes 0.64 71.75
PTBP1 0.0007794 1059 GTEx DepMap Descartes 0.96 30.97
NRP1 0.0007187 1162 GTEx DepMap Descartes 0.79 18.10
ELAVL1 0.0006941 1207 GTEx DepMap Descartes 1.12 27.19
PDIA4 0.0006833 1236 GTEx DepMap Descartes 0.76 38.80
MGAT2 0.0006699 1264 GTEx DepMap Descartes 0.29 15.97
TMEM50A 0.0006335 1348 GTEx DepMap Descartes 1.13 76.48
CNN3 0.0006206 1383 GTEx DepMap Descartes 1.32 106.01
ATP8B2 0.0006186 1392 GTEx DepMap Descartes 0.20 5.03
GNAI1 0.0006087 1418 GTEx DepMap Descartes 0.72 10.86
DDR2 0.0005967 1450 GTEx DepMap Descartes 0.48 7.17


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.04e-01
Mean rank of genes in gene set: 5776.53
Median rank of genes in gene set: 5920
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HMGCR 0.0021825 287 GTEx DepMap Descartes 0.94 33.55
LDLR 0.0011401 656 GTEx DepMap Descartes 0.25 7.81
HMGCS1 0.0009589 833 GTEx DepMap Descartes 0.82 25.30
CYB5B 0.0008716 941 GTEx DepMap Descartes 0.80 29.84
JAKMIP2 0.0008155 1011 GTEx DepMap Descartes 0.76 12.74
DHCR24 0.0006886 1221 GTEx DepMap Descartes 0.33 8.96
FDPS 0.0006844 1229 GTEx DepMap Descartes 2.15 162.19
SLC1A2 0.0005284 1649 GTEx DepMap Descartes 0.61 7.51
PDE10A 0.0004791 1812 GTEx DepMap Descartes 0.21 3.55
SH3BP5 0.0004475 1943 GTEx DepMap Descartes 0.76 34.97
IGF1R 0.0002833 2808 GTEx DepMap Descartes 0.58 6.07
GSTA4 0.0002451 3066 GTEx DepMap Descartes 1.60 153.95
MSMO1 0.0001942 3497 GTEx DepMap Descartes 0.54 40.22
SCAP 0.0001277 4137 GTEx DepMap Descartes 0.37 12.82
SH3PXD2B 0.0001135 4283 GTEx DepMap Descartes 0.10 1.86
NPC1 0.0000733 4799 GTEx DepMap Descartes 0.09 2.53
SCARB1 0.0000237 5596 GTEx DepMap Descartes 0.16 3.44
FDX1 0.0000129 5826 GTEx DepMap Descartes 0.74 33.58
STAR 0.0000048 6014 GTEx DepMap Descartes 0.03 0.97
FREM2 -0.0000009 6162 GTEx DepMap Descartes 0.00 0.00
GRAMD1B -0.0000147 6562 GTEx DepMap Descartes 0.07 1.03
SLC16A9 -0.0000360 7207 GTEx DepMap Descartes 0.18 5.92
PAPSS2 -0.0000364 7225 GTEx DepMap Descartes 0.02 0.80
POR -0.0000493 7619 GTEx DepMap Descartes 0.30 20.36
ERN1 -0.0000659 8078 GTEx DepMap Descartes 0.10 1.61
FRMD5 -0.0000904 8741 GTEx DepMap Descartes 0.13 3.10
FDXR -0.0000987 8916 GTEx DepMap Descartes 0.19 12.88
APOC1 -0.0001021 8979 GTEx DepMap Descartes 1.17 179.43
DHCR7 -0.0001050 9036 GTEx DepMap Descartes 0.19 11.46
BAIAP2L1 -0.0001271 9449 GTEx DepMap Descartes 0.02 0.77


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.30e-01
Mean rank of genes in gene set: 5858.1
Median rank of genes in gene set: 4385
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TUBA1A 0.0027852 223 GTEx DepMap Descartes 58.80 4968.58
MAP1B 0.0024539 253 GTEx DepMap Descartes 18.70 247.42
BASP1 0.0024055 260 GTEx DepMap Descartes 19.65 1702.88
RGMB 0.0012827 561 GTEx DepMap Descartes 0.97 31.88
TUBB2A 0.0012234 599 GTEx DepMap Descartes 6.82 621.77
EYA1 0.0010967 687 GTEx DepMap Descartes 0.32 12.88
PLXNA4 0.0009178 882 GTEx DepMap Descartes 0.35 3.85
EYA4 0.0008359 983 GTEx DepMap Descartes 0.31 7.56
GAP43 0.0008294 994 GTEx DepMap Descartes 6.51 524.17
GREM1 0.0007199 1158 GTEx DepMap Descartes 0.12 1.52
ALK 0.0006962 1203 GTEx DepMap Descartes 0.27 7.85
MAB21L2 0.0006825 1241 GTEx DepMap Descartes 1.93 103.97
TMEM132C 0.0005658 1549 GTEx DepMap Descartes 0.33 10.54
SYNPO2 0.0005345 1632 GTEx DepMap Descartes 0.61 5.67
CNKSR2 0.0004583 1895 GTEx DepMap Descartes 0.31 5.43
TMEFF2 0.0003785 2250 GTEx DepMap Descartes 0.65 28.66
FAT3 0.0003675 2301 GTEx DepMap Descartes 0.38 3.04
MAB21L1 0.0003146 2589 GTEx DepMap Descartes 2.54 130.25
REEP1 0.0001495 3916 GTEx DepMap Descartes 0.62 23.10
SLC6A2 0.0001245 4175 GTEx DepMap Descartes 0.33 16.43
SLC44A5 0.0001046 4385 GTEx DepMap Descartes 0.08 3.12
TUBB2B 0.0000582 5018 GTEx DepMap Descartes 28.59 2264.37
HS3ST5 0.0000570 5033 GTEx DepMap Descartes 0.11 4.29
RBFOX1 -0.0000247 6856 GTEx DepMap Descartes 0.35 14.03
STMN2 -0.0000268 6931 GTEx DepMap Descartes 36.90 2927.40
PTCHD1 -0.0000966 8869 GTEx DepMap Descartes 0.18 2.26
ANKFN1 -0.0001278 9459 GTEx DepMap Descartes 0.03 1.03
KCNB2 -0.0001565 9890 GTEx DepMap Descartes 0.20 7.73
IL7 -0.0001849 10261 GTEx DepMap Descartes 0.88 66.96
EPHA6 -0.0003023 11226 GTEx DepMap Descartes 0.04 1.06


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 7847.58
Median rank of genes in gene set: 8476.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EFNB2 0.0013407 529 GTEx DepMap Descartes 0.65 20.47
ID1 0.0001688 3734 GTEx DepMap Descartes 0.29 42.24
MYRIP 0.0001688 3735 GTEx DepMap Descartes 0.07 1.78
EHD3 0.0000938 4529 GTEx DepMap Descartes 0.04 1.59
IRX3 0.0000738 4791 GTEx DepMap Descartes 0.13 10.02
NOTCH4 0.0000546 5067 GTEx DepMap Descartes 0.19 4.54
TMEM88 0.0000542 5074 GTEx DepMap Descartes 0.09 11.72
CLDN5 0.0000488 5163 GTEx DepMap Descartes 0.14 7.29
PODXL 0.0000336 5415 GTEx DepMap Descartes 0.09 2.06
TEK 0.0000322 5437 GTEx DepMap Descartes 0.00 0.12
NR5A2 0.0000093 5890 GTEx DepMap Descartes 0.00 0.02
CRHBP 0.0000065 5964 GTEx DepMap Descartes 0.01 0.28
CEACAM1 -0.0000058 6296 GTEx DepMap Descartes 0.01 0.46
KANK3 -0.0000465 7530 GTEx DepMap Descartes 0.00 0.23
RASIP1 -0.0000572 7840 GTEx DepMap Descartes 0.02 0.86
CDH13 -0.0000635 8008 GTEx DepMap Descartes 0.03 0.59
SHE -0.0000707 8198 GTEx DepMap Descartes 0.00 0.00
ESM1 -0.0000707 8199 GTEx DepMap Descartes 0.00 0.19
FLT4 -0.0000790 8443 GTEx DepMap Descartes 0.00 0.04
F8 -0.0000815 8510 GTEx DepMap Descartes 0.01 0.15
NPR1 -0.0000842 8577 GTEx DepMap Descartes 0.00 0.11
CDH5 -0.0000899 8727 GTEx DepMap Descartes 0.00 0.06
BTNL9 -0.0000981 8905 GTEx DepMap Descartes 0.00 0.04
TIE1 -0.0001070 9068 GTEx DepMap Descartes 0.00 0.00
ROBO4 -0.0001083 9097 GTEx DepMap Descartes 0.00 0.10
SLCO2A1 -0.0001090 9111 GTEx DepMap Descartes 0.00 0.00
MMRN2 -0.0001118 9164 GTEx DepMap Descartes 0.00 0.02
CHRM3 -0.0001316 9536 GTEx DepMap Descartes 0.32 7.13
CALCRL -0.0001447 9741 GTEx DepMap Descartes 0.00 0.02
KDR -0.0001487 9797 GTEx DepMap Descartes 0.00 0.10


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.84e-01
Mean rank of genes in gene set: 6925.3
Median rank of genes in gene set: 6963.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCDH18 0.0010412 736 GTEx DepMap Descartes 0.08 2.15
PRICKLE1 0.0008932 910 GTEx DepMap Descartes 0.49 14.22
LOX 0.0003421 2431 GTEx DepMap Descartes 0.03 0.78
CDH11 0.0002694 2886 GTEx DepMap Descartes 0.17 5.23
GLI2 0.0001641 3787 GTEx DepMap Descartes 0.02 0.38
LRRC17 0.0001100 4327 GTEx DepMap Descartes 0.02 1.38
PDGFRA 0.0000987 4456 GTEx DepMap Descartes 0.39 10.73
C7 0.0000449 5230 GTEx DepMap Descartes 0.03 0.33
ABCC9 0.0000406 5291 GTEx DepMap Descartes 0.00 0.03
GAS2 0.0000171 5742 GTEx DepMap Descartes 0.02 1.44
PAMR1 0.0000161 5765 GTEx DepMap Descartes 0.00 0.02
DCN 0.0000124 5839 GTEx DepMap Descartes 0.02 0.53
SFRP2 0.0000075 5936 GTEx DepMap Descartes 0.00 0.13
COL6A3 0.0000072 5944 GTEx DepMap Descartes 0.05 0.62
LUM 0.0000059 5983 GTEx DepMap Descartes 0.04 2.04
LAMC3 0.0000058 5986 GTEx DepMap Descartes 0.00 0.02
SCARA5 0.0000050 6009 GTEx DepMap Descartes 0.00 0.00
OGN 0.0000019 6077 GTEx DepMap Descartes 0.00 0.10
COL12A1 -0.0000175 6639 GTEx DepMap Descartes 0.04 0.47
COL27A1 -0.0000184 6671 GTEx DepMap Descartes 0.00 0.03
CCDC80 -0.0000225 6786 GTEx DepMap Descartes 0.04 0.54
COL1A1 -0.0000264 6913 GTEx DepMap Descartes 0.39 11.86
ABCA6 -0.0000293 7014 GTEx DepMap Descartes 0.00 0.06
COL1A2 -0.0000295 7020 GTEx DepMap Descartes 0.20 5.74
FREM1 -0.0000332 7133 GTEx DepMap Descartes 0.01 0.16
MGP -0.0000365 7229 GTEx DepMap Descartes 0.10 7.69
RSPO3 -0.0000369 7244 GTEx DepMap Descartes 0.00 NA
ISLR -0.0000380 7285 GTEx DepMap Descartes 0.00 0.20
IGFBP3 -0.0000574 7845 GTEx DepMap Descartes 0.01 0.49
COL3A1 -0.0000596 7900 GTEx DepMap Descartes 0.12 3.83


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9046.05
Median rank of genes in gene set: 9982.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ROBO1 0.0003604 2344 GTEx DepMap Descartes 0.35 6.52
GRID2 0.0003285 2503 GTEx DepMap Descartes 0.19 5.78
UNC80 0.0002983 2711 GTEx DepMap Descartes 0.34 3.95
HTATSF1 0.0002564 2972 GTEx DepMap Descartes 1.32 67.43
FAM155A 0.0000412 5280 GTEx DepMap Descartes 0.42 6.66
PCSK2 0.0000093 5889 GTEx DepMap Descartes 0.02 0.88
KCTD16 -0.0000080 6354 GTEx DepMap Descartes 0.93 10.47
LAMA3 -0.0000261 6906 GTEx DepMap Descartes 0.02 0.28
DGKK -0.0000398 7338 GTEx DepMap Descartes 0.05 1.27
SORCS3 -0.0000400 7345 GTEx DepMap Descartes 0.04 1.96
PENK -0.0000504 7643 GTEx DepMap Descartes 0.00 0.38
ST18 -0.0000555 7785 GTEx DepMap Descartes 0.01 0.26
TENM1 -0.0000557 7797 GTEx DepMap Descartes 0.07 NA
FGF14 -0.0000636 8014 GTEx DepMap Descartes 0.22 3.13
SLC18A1 -0.0000986 8914 GTEx DepMap Descartes 0.25 10.03
TIAM1 -0.0001184 9287 GTEx DepMap Descartes 0.28 5.56
SLC35F3 -0.0001309 9521 GTEx DepMap Descartes 0.00 0.16
GRM7 -0.0001416 9694 GTEx DepMap Descartes 0.01 0.39
CNTN3 -0.0001584 9914 GTEx DepMap Descartes 0.00 0.12
SLC24A2 -0.0001682 10051 GTEx DepMap Descartes 0.00 0.02
AGBL4 -0.0001810 10206 GTEx DepMap Descartes 0.06 1.82
EML6 -0.0002002 10415 GTEx DepMap Descartes 0.04 0.66
TBX20 -0.0002031 10441 GTEx DepMap Descartes 0.01 0.72
KSR2 -0.0002225 10640 GTEx DepMap Descartes 0.06 0.50
SPOCK3 -0.0002348 10738 GTEx DepMap Descartes 0.10 4.28
C1QL1 -0.0002552 10906 GTEx DepMap Descartes 1.59 196.25
GALNTL6 -0.0002876 11141 GTEx DepMap Descartes 0.05 1.84
CCSER1 -0.0002916 11164 GTEx DepMap Descartes 0.09 NA
GCH1 -0.0003019 11224 GTEx DepMap Descartes 0.21 10.96
CDH18 -0.0003036 11229 GTEx DepMap Descartes 0.02 0.41


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-01
Mean rank of genes in gene set: 6162.14
Median rank of genes in gene set: 6232
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TSPAN5 0.0015244 454 GTEx DepMap Descartes 1.30 49.57
XPO7 0.0008168 1008 GTEx DepMap Descartes 0.40 12.11
RAPGEF2 0.0005195 1684 GTEx DepMap Descartes 0.43 7.84
TRAK2 0.0004557 1907 GTEx DepMap Descartes 0.21 4.87
ANK1 0.0003602 2345 GTEx DepMap Descartes 0.17 2.43
EPB41 0.0003571 2359 GTEx DepMap Descartes 0.80 17.73
TMCC2 0.0002754 2852 GTEx DepMap Descartes 0.10 3.42
FECH 0.0002258 3228 GTEx DepMap Descartes 0.15 2.82
SLC4A1 0.0001379 4022 GTEx DepMap Descartes 0.01 0.45
DENND4A 0.0000750 4774 GTEx DepMap Descartes 0.32 5.03
SPTB 0.0000676 4882 GTEx DepMap Descartes 0.08 1.28
ABCB10 0.0000065 5962 GTEx DepMap Descartes 0.10 3.35
SOX6 0.0000055 5995 GTEx DepMap Descartes 0.09 1.54
ALAS2 0.0000038 6035 GTEx DepMap Descartes 0.03 1.57
CAT -0.0000034 6232 GTEx DepMap Descartes 0.29 18.89
SPECC1 -0.0000147 6565 GTEx DepMap Descartes 0.12 2.50
CPOX -0.0000258 6895 GTEx DepMap Descartes 0.07 3.43
MARCH3 -0.0000308 7056 GTEx DepMap Descartes 0.05 NA
SELENBP1 -0.0000319 7094 GTEx DepMap Descartes 0.00 0.28
RHD -0.0000378 7279 GTEx DepMap Descartes 0.00 0.00
RGS6 -0.0000473 7557 GTEx DepMap Descartes 0.00 0.02
SLC25A21 -0.0000496 7625 GTEx DepMap Descartes 0.00 0.00
GYPC -0.0000549 7767 GTEx DepMap Descartes 0.27 17.93
BLVRB -0.0001558 9883 GTEx DepMap Descartes 0.16 12.09
MICAL2 -0.0001790 10176 GTEx DepMap Descartes 0.01 0.26
TFR2 -0.0001997 10411 GTEx DepMap Descartes 0.14 5.12
GCLC -0.0004843 11907 GTEx DepMap Descartes 0.10 3.64
SNCA -0.0007396 12302 GTEx DepMap Descartes 0.49 23.73
SLC25A37 -0.0009966 12446 GTEx DepMap Descartes 0.48 12.39
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 7707.79
Median rank of genes in gene set: 8087
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FMN1 0.0004511 1927 GTEx DepMap Descartes 0.30 2.94
ITPR2 0.0003027 2677 GTEx DepMap Descartes 0.23 2.85
CTSB 0.0000372 5352 GTEx DepMap Descartes 1.52 50.49
PTPRE 0.0000302 5467 GTEx DepMap Descartes 0.09 2.10
CD74 0.0000194 5682 GTEx DepMap Descartes 1.97 73.62
AXL 0.0000154 5777 GTEx DepMap Descartes 0.03 0.71
FGD2 0.0000063 5968 GTEx DepMap Descartes 0.01 0.17
MS4A4A 0.0000016 6088 GTEx DepMap Descartes 0.17 9.21
RBPJ -0.0000138 6539 GTEx DepMap Descartes 1.51 39.44
HCK -0.0000198 6718 GTEx DepMap Descartes 0.02 1.15
ATP8B4 -0.0000242 6841 GTEx DepMap Descartes 0.02 0.38
CTSC -0.0000280 6975 GTEx DepMap Descartes 0.60 8.45
WWP1 -0.0000407 7367 GTEx DepMap Descartes 0.13 3.99
CYBB -0.0000417 7389 GTEx DepMap Descartes 0.07 1.70
MERTK -0.0000465 7531 GTEx DepMap Descartes 0.02 0.52
CSF1R -0.0000495 7622 GTEx DepMap Descartes 0.04 0.93
SLCO2B1 -0.0000550 7769 GTEx DepMap Descartes 0.02 0.44
CD14 -0.0000599 7916 GTEx DepMap Descartes 0.38 24.75
CPVL -0.0000658 8075 GTEx DepMap Descartes 0.14 6.01
LGMN -0.0000663 8099 GTEx DepMap Descartes 0.38 23.12
SLC9A9 -0.0000684 8147 GTEx DepMap Descartes 0.01 0.50
IFNGR1 -0.0000687 8156 GTEx DepMap Descartes 0.36 20.50
SLC1A3 -0.0000708 8200 GTEx DepMap Descartes 0.02 0.39
MSR1 -0.0000713 8225 GTEx DepMap Descartes 0.05 1.64
SPP1 -0.0000774 8395 GTEx DepMap Descartes 2.59 246.25
ADAP2 -0.0000789 8439 GTEx DepMap Descartes 0.05 2.36
CD163L1 -0.0000829 8543 GTEx DepMap Descartes 0.32 10.86
FGL2 -0.0000870 8654 GTEx DepMap Descartes 0.11 2.16
SFMBT2 -0.0000978 8899 GTEx DepMap Descartes 0.05 0.78
CD163 -0.0001026 8992 GTEx DepMap Descartes 0.05 1.14


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.34e-01
Mean rank of genes in gene set: 7096.14
Median rank of genes in gene set: 7739.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCKS 0.0042371 148 GTEx DepMap Descartes 18.52 662.02
FIGN 0.0028476 216 GTEx DepMap Descartes 0.65 10.79
DST 0.0016835 400 GTEx DepMap Descartes 3.75 24.43
PTN 0.0016221 420 GTEx DepMap Descartes 1.13 123.92
SFRP1 0.0010785 701 GTEx DepMap Descartes 1.43 49.52
LAMA4 0.0003023 2679 GTEx DepMap Descartes 0.22 4.54
LAMB1 0.0002654 2915 GTEx DepMap Descartes 0.42 9.93
SCN7A 0.0001869 3554 GTEx DepMap Descartes 0.19 3.87
VIM 0.0001715 3707 GTEx DepMap Descartes 2.89 157.59
ERBB3 0.0001642 3786 GTEx DepMap Descartes 0.02 0.56
HMGA2 0.0001565 3854 GTEx DepMap Descartes 0.00 0.11
STARD13 0.0000912 4569 GTEx DepMap Descartes 0.04 0.98
SORCS1 0.0000245 5577 GTEx DepMap Descartes 0.14 2.97
MPZ 0.0000187 5701 GTEx DepMap Descartes 0.02 2.05
GRIK3 0.0000159 5768 GTEx DepMap Descartes 0.07 0.71
TRPM3 0.0000015 6092 GTEx DepMap Descartes 0.00 0.11
PLP1 -0.0000107 6443 GTEx DepMap Descartes 0.00 0.15
GAS7 -0.0000310 7063 GTEx DepMap Descartes 0.03 0.39
IL1RAPL2 -0.0000420 7400 GTEx DepMap Descartes 0.00 0.00
LRRTM4 -0.0000460 7521 GTEx DepMap Descartes 0.03 1.50
COL5A2 -0.0000460 7522 GTEx DepMap Descartes 0.06 1.16
NRXN3 -0.0000524 7693 GTEx DepMap Descartes 0.02 0.21
LAMC1 -0.0000555 7786 GTEx DepMap Descartes 0.06 1.00
ERBB4 -0.0000759 8353 GTEx DepMap Descartes 0.07 1.34
OLFML2A -0.0000794 8449 GTEx DepMap Descartes 0.02 0.26
PTPRZ1 -0.0000811 8501 GTEx DepMap Descartes 0.00 0.00
EDNRB -0.0000855 8604 GTEx DepMap Descartes 0.01 0.29
IL1RAPL1 -0.0001060 9052 GTEx DepMap Descartes 0.01 0.56
EGFLAM -0.0001194 9312 GTEx DepMap Descartes 0.11 3.04
COL18A1 -0.0001224 9364 GTEx DepMap Descartes 0.08 1.71


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.76e-01
Mean rank of genes in gene set: 6377.67
Median rank of genes in gene set: 7044
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ACTB 0.0020546 310 GTEx DepMap Descartes 44.54 2955.66
PRKAR2B 0.0012170 603 GTEx DepMap Descartes 1.11 46.07
TPM4 0.0010342 744 GTEx DepMap Descartes 2.65 79.92
CD9 0.0009539 841 GTEx DepMap Descartes 1.54 153.08
ACTN1 0.0009491 846 GTEx DepMap Descartes 1.00 31.02
HIPK2 0.0004429 1956 GTEx DepMap Descartes 0.69 7.20
STON2 0.0004110 2103 GTEx DepMap Descartes 0.17 5.31
ITGA2B 0.0003627 2327 GTEx DepMap Descartes 0.04 1.79
MYH9 0.0002741 2861 GTEx DepMap Descartes 0.40 7.34
TMSB4X 0.0002550 2987 GTEx DepMap Descartes 47.81 4454.26
PDE3A 0.0001485 3924 GTEx DepMap Descartes 0.12 2.29
TLN1 0.0001157 4264 GTEx DepMap Descartes 0.33 5.77
PSTPIP2 0.0000255 5563 GTEx DepMap Descartes 0.02 0.96
TUBB1 0.0000091 5895 GTEx DepMap Descartes 0.00 0.21
MMRN1 0.0000086 5911 GTEx DepMap Descartes 0.00 0.04
SLC2A3 -0.0000041 6254 GTEx DepMap Descartes 0.13 4.55
RAB27B -0.0000042 6258 GTEx DepMap Descartes 0.06 1.41
LIMS1 -0.0000059 6301 GTEx DepMap Descartes 0.79 24.01
FLNA -0.0000084 6374 GTEx DepMap Descartes 0.31 5.40
SPN -0.0000090 6391 GTEx DepMap Descartes 0.04 0.77
ARHGAP6 -0.0000195 6711 GTEx DepMap Descartes 0.00 0.01
GP1BA -0.0000264 6914 GTEx DepMap Descartes 0.00 0.02
THBS1 -0.0000303 7044 GTEx DepMap Descartes 0.02 0.28
TRPC6 -0.0000354 7190 GTEx DepMap Descartes 0.00 0.05
FERMT3 -0.0000363 7223 GTEx DepMap Descartes 0.08 3.61
P2RX1 -0.0000403 7350 GTEx DepMap Descartes 0.01 0.22
FLI1 -0.0000493 7617 GTEx DepMap Descartes 0.02 0.44
PLEK -0.0000505 7648 GTEx DepMap Descartes 0.06 2.34
ITGB3 -0.0000562 7807 GTEx DepMap Descartes 0.00 0.00
MYLK -0.0000593 7894 GTEx DepMap Descartes 0.05 0.51


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.30e-01
Mean rank of genes in gene set: 5646.24
Median rank of genes in gene set: 6011
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FOXP1 0.0014062 501 GTEx DepMap Descartes 2.10 36.09
TOX 0.0012369 593 GTEx DepMap Descartes 0.94 33.57
CELF2 0.0011631 642 GTEx DepMap Descartes 1.23 21.68
GNG2 0.0008185 1006 GTEx DepMap Descartes 1.19 50.89
STK39 0.0007321 1134 GTEx DepMap Descartes 0.73 31.56
FYN 0.0006334 1351 GTEx DepMap Descartes 2.20 86.48
TMSB10 0.0004728 1841 GTEx DepMap Descartes 76.28 25945.51
PITPNC1 0.0004320 2011 GTEx DepMap Descartes 0.39 9.30
MBNL1 0.0004287 2030 GTEx DepMap Descartes 0.50 10.48
CD44 0.0003119 2612 GTEx DepMap Descartes 1.71 49.51
SORL1 0.0003071 2650 GTEx DepMap Descartes 0.41 5.05
BACH2 0.0002341 3154 GTEx DepMap Descartes 0.29 4.94
PDE3B 0.0002077 3387 GTEx DepMap Descartes 0.25 5.84
ABLIM1 0.0001862 3562 GTEx DepMap Descartes 0.36 6.69
B2M 0.0001862 3563 GTEx DepMap Descartes 16.45 955.13
DOCK10 0.0001841 3577 GTEx DepMap Descartes 0.12 2.64
ANKRD44 0.0000781 4728 GTEx DepMap Descartes 0.21 4.49
BCL2 0.0000758 4764 GTEx DepMap Descartes 0.54 12.74
ITPKB 0.0000173 5737 GTEx DepMap Descartes 0.02 0.38
ARHGAP15 0.0000111 5868 GTEx DepMap Descartes 0.06 2.68
ARHGDIB 0.0000067 5957 GTEx DepMap Descartes 0.71 83.00
WIPF1 0.0000025 6065 GTEx DepMap Descartes 0.14 4.25
SAMD3 0.0000006 6122 GTEx DepMap Descartes 0.02 0.56
PLEKHA2 -0.0000068 6321 GTEx DepMap Descartes 0.05 1.39
PRKCH -0.0000280 6972 GTEx DepMap Descartes 0.02 0.94
MSN -0.0000318 7090 GTEx DepMap Descartes 0.24 9.01
LEF1 -0.0000393 7321 GTEx DepMap Descartes 0.06 2.39
ETS1 -0.0000431 7428 GTEx DepMap Descartes 0.07 2.12
ARID5B -0.0000550 7770 GTEx DepMap Descartes 0.28 5.08
IKZF1 -0.0000600 7919 GTEx DepMap Descartes 0.07 1.52


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Cycling cells: Cycling DCs (curated markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.24e-03
Mean rank of genes in gene set: 11.5
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0169205 4 GTEx DepMap Descartes 18.45 517.59
MKI67 0.0134630 19 GTEx DepMap Descartes 8.80 114.09


Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.24e-03
Mean rank of genes in gene set: 11.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0169205 4 GTEx DepMap Descartes 18.45 517.59
MKI67 0.0134630 19 GTEx DepMap Descartes 8.80 114.09


Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.24e-03
Mean rank of genes in gene set: 11.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0169205 4 GTEx DepMap Descartes 18.45 517.59
MKI67 0.0134630 19 GTEx DepMap Descartes 8.80 114.09