Program: 12. Neuroblastoma: Adrenergic #2.

Program: 12. Neuroblastoma: Adrenergic #2.

Program description and justification of annotation: 12.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 CHGA 0.0197936 chromogranin A GTEx DepMap Descartes 3.32 6803.85
2 ERBB4 0.0192517 erb-b2 receptor tyrosine kinase 4 GTEx DepMap Descartes 4.42 1593.77
3 DLK1 0.0169486 delta like non-canonical Notch ligand 1 GTEx DepMap Descartes 1.54 1490.73
4 PDIA6 0.0169478 protein disulfide isomerase family A member 6 GTEx DepMap Descartes 1.76 2883.91
5 STRA6 0.0169388 signaling receptor and transporter of retinol STRA6 GTEx DepMap Descartes 0.80 1103.42
6 OPRM1 0.0166524 opioid receptor mu 1 GTEx DepMap Descartes 0.81 228.32
7 FAM155A 0.0150706 NA GTEx DepMap Descartes 5.30 2348.91
8 RET 0.0145396 ret proto-oncogene GTEx DepMap Descartes 0.58 405.80
9 NOL10 0.0137002 nucleolar protein 10 GTEx DepMap Descartes 1.07 1284.86
10 PDE10A 0.0133388 phosphodiesterase 10A GTEx DepMap Descartes 1.14 511.79
11 ST18 0.0130227 ST18 C2H2C-type zinc finger transcription factor GTEx DepMap Descartes 0.51 354.01
12 TRIB2 0.0123688 tribbles pseudokinase 2 GTEx DepMap Descartes 1.61 1502.09
13 ADARB2 0.0122200 adenosine deaminase RNA specific B2 (inactive) GTEx DepMap Descartes 0.67 285.33
14 MEG3 0.0118689 maternally expressed 3 GTEx DepMap Descartes 6.91 1982.35
15 NR2F1 0.0116732 nuclear receptor subfamily 2 group F member 1 GTEx DepMap Descartes 0.50 533.72
16 RRM2 0.0116163 ribonucleotide reductase regulatory subunit M2 GTEx DepMap Descartes 0.60 718.97
17 CACNA1D 0.0111783 calcium voltage-gated channel subunit alpha1 D GTEx DepMap Descartes 0.54 232.76
18 ROCK2 0.0110683 Rho associated coiled-coil containing protein kinase 2 GTEx DepMap Descartes 0.96 461.45
19 KCNT1 0.0109752 potassium sodium-activated channel subfamily T member 1 GTEx DepMap Descartes 0.27 137.38
20 ODC1 0.0108540 ornithine decarboxylase 1 GTEx DepMap Descartes 0.88 1565.47
21 FKBP10 0.0105957 FKBP prolyl isomerase 10 GTEx DepMap Descartes 0.45 608.22
22 FAM13A 0.0105571 family with sequence similarity 13 member A GTEx DepMap Descartes 0.51 362.50
23 TLE2 0.0099061 TLE family member 2, transcriptional corepressor GTEx DepMap Descartes 0.40 564.19
24 PLD5 0.0094533 phospholipase D family member 5 GTEx DepMap Descartes 0.71 308.22
25 HPCAL1 0.0092682 hippocalcin like 1 GTEx DepMap Descartes 0.66 514.35
26 CACNA2D2 0.0090320 calcium voltage-gated channel auxiliary subunit alpha2delta 2 GTEx DepMap Descartes 0.28 198.57
27 CEP112 0.0089826 centrosomal protein 112 GTEx DepMap Descartes 0.63 736.44
28 ZMAT4 0.0089087 zinc finger matrin-type 4 GTEx DepMap Descartes 0.44 718.97
29 TAF1B 0.0088106 TATA-box binding protein associated factor, RNA polymerase I subunit B GTEx DepMap Descartes 0.52 944.29
30 AFF3 0.0086867 AF4/FMR2 family member 3 GTEx DepMap Descartes 0.85 345.35
31 LHX9 0.0086657 LIM homeobox 9 GTEx DepMap Descartes 0.18 97.70
32 ATP8A2 0.0083242 ATPase phospholipid transporting 8A2 GTEx DepMap Descartes 0.32 134.48
33 NKAIN3 0.0083236 sodium/potassium transporting ATPase interacting 3 GTEx DepMap Descartes 0.20 414.63
34 CYB561 0.0083061 cytochrome b561 GTEx DepMap Descartes 0.45 571.16
35 E2F6 0.0082654 E2F transcription factor 6 GTEx DepMap Descartes 0.35 430.02
36 FGF14 0.0082252 fibroblast growth factor 14 GTEx DepMap Descartes 2.68 861.47
37 SLC35F3 0.0079604 solute carrier family 35 member F3 GTEx DepMap Descartes 0.34 397.51
38 RAP1GAP2 0.0079040 RAP1 GTPase activating protein 2 GTEx DepMap Descartes 0.92 506.60
39 GRHL1 0.0078089 grainyhead like transcription factor 1 GTEx DepMap Descartes 0.27 203.32
40 COL4A5 0.0077919 collagen type IV alpha 5 chain GTEx DepMap Descartes 0.15 93.67
41 PCSK2 0.0075864 proprotein convertase subtilisin/kexin type 2 GTEx DepMap Descartes 0.41 351.78
42 DSCAML1 0.0075858 DS cell adhesion molecule like 1 GTEx DepMap Descartes 0.22 120.23
43 CPLX2 0.0074677 complexin 2 GTEx DepMap Descartes 0.38 309.83
44 SEZ6 0.0073808 seizure related 6 homolog GTEx DepMap Descartes 0.21 201.73
45 SLC18A1 0.0073638 solute carrier family 18 member A1 GTEx DepMap Descartes 0.29 394.49
46 CHGB 0.0073304 chromogranin B GTEx DepMap Descartes 1.18 2045.75
47 IGF2 0.0073169 insulin like growth factor 2 GTEx DepMap Descartes 0.14 104.39
48 LPIN1 0.0072349 lipin 1 GTEx DepMap Descartes 1.74 1195.37
49 NGFR 0.0070383 nerve growth factor receptor GTEx DepMap Descartes 0.17 216.73
50 KCNK9 0.0070254 potassium two pore domain channel subfamily K member 9 GTEx DepMap Descartes 0.14 105.85


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UMAP plots showing activity of gene expression program identified in community:12. Neuroblastoma: Adrenergic #2

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DESCARTES_FETAL_ADRENAL_SYMPATHOBLASTS 3.45e-07 18.49 6.86 2.31e-04 2.31e-04
7CHGA, OPRM1, RET, ST18, SLC35F3, PCSK2, KCNK9
 117
BUSSLINGER_DUODENAL_EC_CELLS 2.46e-04 28.45 5.35 2.07e-02 1.65e-01
3CHGA, PCSK2, CHGB
 31
DESCARTES_MAIN_FETAL_SYMPATHOBLASTS 7.41e-05 20.48 5.17 1.24e-02 4.97e-02
4CHGA, CYB561, SLC18A1, CHGB
 57
MENON_FETAL_KIDNEY_2_NEPHRON_PROGENITOR_CELLS 6.96e-04 19.44 3.72 4.24e-02 4.67e-01
3ERBB4, TRIB2, ODC1
 44
ZHONG_PFC_MAJOR_TYPES_INTERNEURON 2.28e-03 32.49 3.53 8.50e-02 1.00e+00
2ERBB4, MEG3
 18
BUSSLINGER_GASTRIC_OXYNTIC_ENTEROCHROMAFFIN_LIKE_CELLS 3.47e-04 13.41 3.43 2.41e-02 2.33e-01
4CHGA, FGF14, CPLX2, CHGB
 85
DESCARTES_FETAL_STOMACH_NEUROENDOCRINE_CELLS 1.01e-03 16.95 3.26 4.85e-02 6.78e-01
3CHGA, ST18, SLC18A1
 50
DESCARTES_FETAL_STOMACH_PDE1C_ACSM3_POSITIVE_CELLS 3.40e-03 26.01 2.87 1.20e-01 1.00e+00
2ERBB4, ADARB2
 22
MANNO_MIDBRAIN_NEUROTYPES_HDA2 1.99e-05 6.22 2.76 6.69e-03 1.34e-02
10ERBB4, DLK1, FAM155A, RET, ADARB2, MEG3, ATP8A2, RAP1GAP2, PCSK2, SLC18A1
 513
DESCARTES_FETAL_INTESTINE_CHROMAFFIN_CELLS 9.77e-04 10.06 2.58 4.85e-02 6.56e-01
4CHGA, ST18, RAP1GAP2, SLC18A1
 112
GAO_LARGE_INTESTINE_ADULT_CA_ENTEROENDOCRINE_CELLS 1.89e-04 6.67 2.51 2.07e-02 1.27e-01
7ST18, CACNA1D, AFF3, CPLX2, SEZ6, SLC18A1, CHGB
 312
MANNO_MIDBRAIN_NEUROTYPES_HDA1 5.75e-05 5.45 2.42 1.24e-02 3.86e-02
10CHGA, ERBB4, DLK1, FAM155A, ADARB2, MEG3, ATP8A2, PCSK2, SLC18A1, LPIN1
 584
MANNO_MIDBRAIN_NEUROTYPES_HDA 1.11e-04 5.52 2.35 1.50e-02 7.48e-02
9CHGA, ERBB4, DLK1, FAM155A, ADARB2, MEG3, TLE2, RAP1GAP2, SLC18A1
 506
TRAVAGLINI_LUNG_NEUROENDOCRINE_CELL 1.59e-03 8.76 2.26 6.29e-02 1.00e+00
4MEG3, PCSK2, CPLX2, CHGB
 128
BUSSLINGER_GASTRIC_D_CELLS 5.48e-03 20.00 2.24 1.60e-01 1.00e+00
2PCSK2, CHGB
 28
MANNO_MIDBRAIN_NEUROTYPES_HNBML5 3.58e-04 5.21 2.10 2.41e-02 2.41e-01
8CHGA, FAM155A, ST18, ADARB2, MEG3, FGF14, RAP1GAP2, LPIN1
 465
DESCARTES_FETAL_LUNG_VISCERAL_NEURONS 1.39e-03 6.71 2.06 6.23e-02 9.35e-01
5PLD5, NKAIN3, SEZ6, NGFR, KCNK9
 212
MANNO_MIDBRAIN_NEUROTYPES_HNBM 9.48e-04 5.90 2.04 4.85e-02 6.36e-01
6ST18, ZMAT4, RAP1GAP2, PCSK2, DSCAML1, SEZ6
 295
MANNO_MIDBRAIN_NEUROTYPES_HNBGABA 2.46e-04 4.51 2.00 2.07e-02 1.65e-01
10CHGA, OPRM1, FAM155A, MEG3, ATP8A2, FGF14, RAP1GAP2, PCSK2, SEZ6, LPIN1
 703
MENON_FETAL_KIDNEY_3_STROMAL_CELLS 4.01e-03 10.22 1.99 1.35e-01 1.00e+00
3MEG3, NR2F1, IGF2
 81

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_PANCREAS_BETA_CELLS 1.10e-02 13.70 1.56 5.48e-01 5.48e-01
2CHGA, PCSK2
 40
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2RET, CACNA2D2
 200
HALLMARK_KRAS_SIGNALING_UP 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2TRIB2, IGF2
 200
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 3.62e-01 2.28 0.06 1.00e+00 1.00e+00
1PDIA6
 113
HALLMARK_SPERMATOGENESIS 4.15e-01 1.90 0.05 1.00e+00 1.00e+00
1LPIN1
 135
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1ODC1
 158
HALLMARK_UV_RESPONSE_UP 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1RET
 158
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1ODC1
 199
HALLMARK_G2M_CHECKPOINT 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ODC1
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1RET
 200
HALLMARK_MYOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1LPIN1
 200
HALLMARK_MTORC1_SIGNALING 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1RRM2
 200
HALLMARK_E2F_TARGETS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1RRM2
 200
HALLMARK_MYC_TARGETS_V1 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ODC1
 200
HALLMARK_GLYCOLYSIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1LHX9
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_MITOTIC_SPINDLE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 199
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_GLUTATHIONE_METABOLISM 1.67e-02 10.84 1.24 1.00e+00 1.00e+00
2RRM2, ODC1
 50
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 3.47e-02 7.23 0.84 1.00e+00 1.00e+00
2CACNA1D, CACNA2D2
 74
KEGG_CARDIAC_MUSCLE_CONTRACTION 3.90e-02 6.76 0.78 1.00e+00 1.00e+00
2CACNA1D, CACNA2D2
 79
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 4.26e-02 6.43 0.74 1.00e+00 1.00e+00
2CACNA1D, CACNA2D2
 83
KEGG_DILATED_CARDIOMYOPATHY 4.93e-02 5.92 0.69 1.00e+00 1.00e+00
2CACNA1D, CACNA2D2
 90
KEGG_MAPK_SIGNALING_PATHWAY 8.58e-02 3.02 0.60 1.00e+00 1.00e+00
3CACNA1D, CACNA2D2, FGF14
 267
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 7.56e-02 4.61 0.54 1.00e+00 1.00e+00
2CACNA1D, ROCK2
 115
KEGG_PURINE_METABOLISM 1.29e-01 3.32 0.39 1.00e+00 1.00e+00
2PDE10A, RRM2
 159
KEGG_CALCIUM_SIGNALING_PATHWAY 1.55e-01 2.96 0.35 1.00e+00 1.00e+00
2ERBB4, CACNA1D
 178
KEGG_ENDOCYTOSIS 1.59e-01 2.91 0.34 1.00e+00 1.00e+00
2ERBB4, RET
 181
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 2.03e-01 2.47 0.29 1.00e+00 1.00e+00
2ROCK2, FGF14
 213
KEGG_THYROID_CANCER 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1RET
 29
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2RET, FGF14
 325
KEGG_TYPE_II_DIABETES_MELLITUS 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1CACNA1D
 47
KEGG_ARGININE_AND_PROLINE_METABOLISM 1.94e-01 4.81 0.12 1.00e+00 1.00e+00
1ODC1
 54
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1ROCK2
 56
KEGG_P53_SIGNALING_PATHWAY 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1RRM2
 68
KEGG_MELANOMA 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1FGF14
 71
KEGG_TGF_BETA_SIGNALING_PATHWAY 2.90e-01 3.00 0.07 1.00e+00 1.00e+00
1ROCK2
 86
KEGG_ERBB_SIGNALING_PATHWAY 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1ERBB4
 87

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2p25 2.31e-11 29.19 12.68 6.41e-09 6.41e-09
10PDIA6, NOL10, RRM2, ROCK2, ODC1, HPCAL1, TAF1B, E2F6, GRHL1, LPIN1
 117
chr13q33 2.00e-02 9.82 1.13 1.00e+00 1.00e+00
2FAM155A, FGF14
 55
chr20p12 6.35e-02 5.11 0.59 1.00e+00 1.00e+00
2PCSK2, CHGB
 104
chr14q32 4.65e-01 1.47 0.29 1.00e+00 1.00e+00
3CHGA, DLK1, MEG3
 546
chr3p21 3.32e-01 1.72 0.20 1.00e+00 1.00e+00
2CACNA1D, CACNA2D2
 304
chr2q34 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1ERBB4
 45
chr17q21 6.95e-01 1.14 0.13 1.00e+00 1.00e+00
2FKBP10, NGFR
 457
chr1q43 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1PLD5
 60
chr5q15 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1NR2F1
 60
chr4q22 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1FAM13A
 70
chr8q11 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1ST18
 70
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1LHX9
 71
chr2p24 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1TRIB2
 74
chr6q27 2.58e-01 3.45 0.08 1.00e+00 1.00e+00
1PDE10A
 75
chr10p15 2.90e-01 3.00 0.07 1.00e+00 1.00e+00
1ADARB2
 86
chr8q12 2.95e-01 2.93 0.07 1.00e+00 1.00e+00
1NKAIN3
 88
chr17q24 3.12e-01 2.74 0.07 1.00e+00 1.00e+00
1CEP112
 94
chr8p11 3.15e-01 2.71 0.07 1.00e+00 1.00e+00
1ZMAT4
 95
chr17q23 3.59e-01 2.30 0.06 1.00e+00 1.00e+00
1CYB561
 112
chr15q24 3.69e-01 2.22 0.05 1.00e+00 1.00e+00
1STRA6
 116

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
TAXCREB_02 5.10e-03 20.80 2.32 6.76e-01 1.00e+00
2DLK1, NOL10
 27
CAGNYGKNAAA_UNKNOWN 3.61e-03 10.64 2.07 5.84e-01 1.00e+00
3TRIB2, CACNA2D2, AFF3
 78
TAATTA_CHX10_01 1.83e-04 4.34 2.00 2.07e-01 2.07e-01
11ERBB4, OPRM1, ADARB2, NR2F1, HPCAL1, AFF3, GRHL1, COL4A5, PCSK2, DSCAML1, SEZ6
 823
NRSF_01 6.61e-03 8.48 1.66 7.49e-01 1.00e+00
3CHGA, PCSK2, SEZ6
 97
OCT1_02 9.69e-03 5.18 1.34 8.21e-01 1.00e+00
4ERBB4, CACNA1D, AFF3, PCSK2
 214
MYOGNF1_01 1.55e-02 11.31 1.29 8.21e-01 1.00e+00
2ROCK2, SEZ6
 48
FOXF2_TARGET_GENES 1.98e-02 63.54 1.27 8.21e-01 1.00e+00
1HPCAL1
 5
AACTTT_UNKNOWN 5.37e-03 2.54 1.26 6.76e-01 1.00e+00
14ERBB4, DLK1, ST18, NR2F1, CACNA1D, ROCK2, HPCAL1, ZMAT4, AFF3, ATP8A2, NKAIN3, FGF14, COL4A5, DSCAML1
 1928
IGLV5_37_TARGET_GENES 9.66e-03 3.24 1.22 8.21e-01 1.00e+00
7TRIB2, CACNA1D, KCNT1, CYB561, E2F6, IGF2, LPIN1
 636
PTF1BETA_Q6 1.54e-02 4.49 1.17 8.21e-01 1.00e+00
4PDE10A, ST18, AFF3, FGF14
 246
AAAYRNCTG_UNKNOWN 1.46e-02 3.75 1.16 8.21e-01 1.00e+00
5ERBB4, NR2F1, LHX9, COL4A5, DSCAML1
 375
CP2_02 1.69e-02 4.37 1.13 8.21e-01 1.00e+00
4NR2F1, ODC1, HPCAL1, CPLX2
 253
E47_02 1.71e-02 4.35 1.13 8.21e-01 1.00e+00
4TRIB2, AFF3, DSCAML1, NGFR
 254
CTTTGA_LEF1_Q2 1.27e-02 2.53 1.12 8.21e-01 1.00e+00
10CHGA, ERBB4, STRA6, RET, NR2F1, ROCK2, CACNA2D2, ZMAT4, AFF3, FGF14
 1247
HSF2_01 1.82e-02 4.26 1.11 8.21e-01 1.00e+00
4NR2F1, CACNA1D, CACNA2D2, KCNK9
 259
CEBPB_01 2.00e-02 4.13 1.07 8.21e-01 1.00e+00
4ERBB4, ST18, AFF3, FGF14
 267
LEF1_Q6 2.00e-02 4.13 1.07 8.21e-01 1.00e+00
4ZMAT4, AFF3, LHX9, SEZ6
 267
AFP1_Q6 2.03e-02 4.12 1.07 8.21e-01 1.00e+00
4NR2F1, AFF3, PCSK2, DSCAML1
 268
EGR_Q6 2.33e-02 3.94 1.02 9.11e-01 1.00e+00
4PDE10A, CACNA1D, PLD5, PCSK2
 280
ISL1_TARGET_GENES 2.90e-02 2.56 0.97 9.25e-01 1.00e+00
7FAM155A, CACNA1D, FAM13A, CEP112, ZMAT4, CYB561, CHGB
 803

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_RESPONSE_TO_AUDITORY_STIMULUS 3.72e-03 24.78 2.74 1.00e+00 1.00e+00
2STRA6, ATP8A2
 23
GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH 5.87e-03 19.27 2.16 1.00e+00 1.00e+00
2ATP8A2, IGF2
 29
GOBP_EATING_BEHAVIOR 6.27e-03 18.58 2.09 1.00e+00 1.00e+00
2OPRM1, ATP8A2
 30
GOBP_RESPONSE_TO_ACETYLCHOLINE 6.27e-03 18.58 2.09 1.00e+00 1.00e+00
2OPRM1, ROCK2
 30
GOBP_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE 8.47e-03 15.77 1.78 1.00e+00 1.00e+00
2RRM2, E2F6
 35
GOBP_FEEDING_BEHAVIOR 5.88e-03 8.86 1.73 1.00e+00 1.00e+00
3STRA6, OPRM1, ATP8A2
 93
GOBP_ARTERY_DEVELOPMENT 6.24e-03 8.67 1.70 1.00e+00 1.00e+00
3STRA6, FKBP10, NGFR
 95
GOBP_VITAMIN_TRANSPORT 1.15e-02 13.35 1.52 1.00e+00 1.00e+00
2STRA6, SLC35F3
 41
GOBP_SEMI_LUNAR_VALVE_DEVELOPMENT 1.15e-02 13.35 1.52 1.00e+00 1.00e+00
2STRA6, ROCK2
 41
GOBP_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION 1.20e-02 13.01 1.48 1.00e+00 1.00e+00
2ROCK2, GRHL1
 42
GOBP_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT 6.36e-03 4.65 1.43 1.00e+00 1.00e+00
5OPRM1, FAM155A, CACNA1D, CACNA2D2, FGF14
 304
GOBP_EMBRYONIC_MORPHOGENESIS 5.50e-03 3.62 1.37 1.00e+00 1.00e+00
7STRA6, RET, ROCK2, AFF3, ATP8A2, DSCAML1, IGF2
 569
GOBP_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 1.49e-02 11.57 1.32 1.00e+00 1.00e+00
2CHGA, CPLX2
 47
GOBP_G0_TO_G1_TRANSITION 1.49e-02 11.57 1.32 1.00e+00 1.00e+00
2RRM2, E2F6
 47
GOBP_PUTRESCINE_BIOSYNTHETIC_PROCESS 1.98e-02 63.54 1.27 1.00e+00 1.00e+00
1ODC1
 5
GOBP_POSITIVE_REGULATION_OF_NEURON_MATURATION 1.98e-02 63.54 1.27 1.00e+00 1.00e+00
1RET
 5
GOBP_EXOCRINE_PANCREAS_DEVELOPMENT 1.98e-02 63.54 1.27 1.00e+00 1.00e+00
1IGF2
 5
GOBP_NEGATIVE_REGULATION_OF_MYOSIN_LIGHT_CHAIN_PHOSPHATASE_ACTIVITY 1.98e-02 63.54 1.27 1.00e+00 1.00e+00
1ROCK2
 5
GOBP_POSITIVE_REGULATION_OF_ODONTOGENESIS 1.98e-02 63.54 1.27 1.00e+00 1.00e+00
1NGFR
 5
GOBP_CGMP_CATABOLIC_PROCESS 1.98e-02 63.54 1.27 1.00e+00 1.00e+00
1PDE10A
 5

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE8678_IL7R_LOW_VS_HIGH_EFF_CD8_TCELL_UP 1.06e-03 7.16 2.19 1.00e+00 1.00e+00
5CACNA1D, KCNT1, FKBP10, RAP1GAP2, LPIN1
 199
GSE20366_CD103_POS_VS_CD103_KLRG1_DP_TREG_DN 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5DLK1, CEP112, ZMAT4, CYB561, RAP1GAP2
 200
GSE339_CD8POS_VS_CD4CD8DN_DC_IN_CULTURE_UP 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5ERBB4, RRM2, ODC1, HPCAL1, SEZ6
 200
GSE43956_WT_VS_SGK1_KO_TH17_DIFFERENTIATED_CD4_TCELL_UP 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5MEG3, TAF1B, LHX9, CYB561, CHGB
 200
GSE29614_CTRL_VS_TIV_FLU_VACCINE_PBMC_2007_UP 6.35e-03 5.87 1.52 1.00e+00 1.00e+00
4ERBB4, ADARB2, COL4A5, KCNK9
 189
GSE29164_CD8_TCELL_VS_CD8_TCELL_AND_IL12_TREATED_MELANOMA_DAY7_DN 7.07e-03 5.69 1.47 1.00e+00 1.00e+00
4RRM2, FAM13A, E2F6, FGF14
 195
GSE19401_PLN_VS_PEYERS_PATCH_FOLLICULAR_DC_UP 7.20e-03 5.66 1.47 1.00e+00 1.00e+00
4PDIA6, TRIB2, MEG3, NR2F1
 196
GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_OLD_UP 7.32e-03 5.63 1.46 1.00e+00 1.00e+00
4DLK1, FAM13A, CYB561, RAP1GAP2
 197
GSE24814_STAT5_KO_VS_WT_PRE_BCELL_UP 7.32e-03 5.63 1.46 1.00e+00 1.00e+00
4CHGA, CACNA1D, TLE2, PCSK2
 197
GSE360_L_MAJOR_VS_T_GONDII_DC_DN 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4CHGA, CACNA1D, TAF1B, COL4A5
 198
GSE36527_CD62L_HIGH_VS_CD62L_LOW_TREG_CD69_NEG_KLRG1_NEG_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4STRA6, ADARB2, CEP112, CPLX2
 199
GSE40184_HEALTHY_VS_HCV_INFECTED_DONOR_PBMC_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4HPCAL1, AFF3, GRHL1, CPLX2
 199
GSE41978_ID2_KO_AND_BIM_KO_VS_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4RRM2, ODC1, COL4A5, SLC18A1
 199
GSE7852_LN_VS_FAT_TCONV_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4ODC1, CYB561, RAP1GAP2, IGF2
 200
GSE9650_GP33_VS_GP276_LCMV_SPECIFIC_EXHAUSTED_CD8_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4STRA6, FKBP10, CPLX2, IGF2
 200
GSE16450_CTRL_VS_IFNA_6H_STIM_IMMATURE_NEURON_CELL_LINE_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4AFF3, ATP8A2, CYB561, GRHL1
 200
GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP 2.00e-02 5.54 1.09 1.00e+00 1.00e+00
3CYB561, IGF2, KCNK9
 147
GSE5589_WT_VS_IL10_KO_LPS_STIM_MACROPHAGE_180MIN_DN 2.30e-02 5.25 1.03 1.00e+00 1.00e+00
3CHGA, HPCAL1, GRHL1
 155
GSE5589_WT_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_UP 2.30e-02 5.25 1.03 1.00e+00 1.00e+00
3STRA6, TAF1B, E2F6
 155
GSE6269_E_COLI_VS_STREP_PNEUMO_INF_PBMC_UP 2.82e-02 4.83 0.95 1.00e+00 1.00e+00
3MEG3, FKBP10, ATP8A2
 168

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
ST18 11 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
NR2F1 15 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TLE2 23 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZMAT4 28 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible RBP.
TAF1B 29 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Pol I TAF that contacts the rDNA promoter in conjunction with TBP and UBF (PMID: 7491500). No clear evidence that it directly confers sequence specificity.
AFF3 30 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 8555498) only says that In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose - thats more consistent with nonspecific DNA binding. The key issue is whether the Transcription factor AF4/FMR2 (IPR007797) domain really is sequence specific. Most of the work has been done on the one Drosophila ortholog, lilliuputian. I see no evidence of DNA binding. Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 261712
LHX9 31 Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None
E2F6 35 Yes Known motif Monomer or homomultimer In vivo/Misc source None None
GRHL1 39 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
EBF3 76 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
AMH 84 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PLXNB2 86 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NCOR2 99 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 2 SANT domains, and no other putative DNA-binding domains
GPR155 103 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RXRA 108 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CDK5RAP3 111 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HOXD10 115 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ADAMTS19 132 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook None
FLNA 134 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Go annotation is based on (PMID: 15684392), which shows that it binds FOXC1 and PBX1 but doesnt show evidence for binding to DNA
TLE1 136 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB14_TTGAACGGTTCTGAAC-1 Neurons:adrenal_medulla_cell_line 0.18 687.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.25, MSC: 0.23, iPS_cells:CRL2097_foreskin: 0.22, Embryonic_stem_cells: 0.22, Smooth_muscle_cells:bronchial: 0.22, Tissue_stem_cells:CD326-CD56+: 0.22, iPS_cells:skin_fibroblast: 0.21
NB14_CGCTATCGTACCGTAT-1 Neurons:adrenal_medulla_cell_line 0.20 628.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.2, Tissue_stem_cells:CD326-CD56+: 0.2, Embryonic_stem_cells: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19
NB14_CAGATCATCCTACAGA-1 Neurons:adrenal_medulla_cell_line 0.18 580.86
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neuroepithelial_cell:ESC-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, Tissue_stem_cells:CD326-CD56+: 0.18, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16
NB14_ATAACGCTCTTTAGTC-1 Neurons:adrenal_medulla_cell_line 0.16 528.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.21
NB14_ATCATCTTCCAAATGC-1 Neurons:adrenal_medulla_cell_line 0.19 488.01
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.18, Embryonic_stem_cells: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Tissue_stem_cells:CD326-CD56+: 0.17
NB14_TTCTTAGAGTACGTAA-1 Neurons:adrenal_medulla_cell_line 0.15 476.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.21, Tissue_stem_cells:CD326-CD56+: 0.2, MSC: 0.2, Smooth_muscle_cells:bronchial: 0.2, Neurons:Schwann_cell: 0.2, Tissue_stem_cells:lipoma-derived_MSC: 0.2, Embryonic_stem_cells: 0.2
NB14_AGGTCATAGTACCGGA-1 Neurons:adrenal_medulla_cell_line 0.16 447.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.19, Tissue_stem_cells:CD326-CD56+: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, Embryonic_stem_cells: 0.18
NB14_CCTACACCATACGCCG-1 Neurons:adrenal_medulla_cell_line 0.17 386.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, Embryonic_stem_cells: 0.17, iPS_cells:PDB_2lox-22: 0.17
NB14_TACCTATGTCAACTGT-1 Neurons:adrenal_medulla_cell_line 0.16 379.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.21, Embryonic_stem_cells: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, Tissue_stem_cells:CD326-CD56+: 0.19
NB14_GTTCTCGCAAGAAAGG-1 Neurons:adrenal_medulla_cell_line 0.16 371.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_2lox-22: 0.15, iPS_cells:PDB_2lox-21: 0.15
NB14_CTCTAATCATCCTTGC-1 Neurons:adrenal_medulla_cell_line 0.17 367.96
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB14_AGCTCTCAGACGACGT-1 Neurons:adrenal_medulla_cell_line 0.15 346.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, Tissue_stem_cells:CD326-CD56+: 0.18, MSC: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, Smooth_muscle_cells:vascular: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17
NB14_CTTGGCTGTAGCTAAA-1 Neurons:adrenal_medulla_cell_line 0.17 343.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Tissue_stem_cells:CD326-CD56+: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.16, Embryonic_stem_cells: 0.16
NB14_TATGCCCAGATGCCTT-1 Neurons:adrenal_medulla_cell_line 0.16 332.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Tissue_stem_cells:CD326-CD56+: 0.17, iPS_cells:PDB_2lox-22: 0.17
NB14_ATTTCTGCATATGAGA-1 Neurons:adrenal_medulla_cell_line 0.18 321.81
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, Tissue_stem_cells:CD326-CD56+: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16
NB14_TACCTATTCCGCTGTT-1 Neurons:adrenal_medulla_cell_line 0.15 321.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Embryonic_stem_cells: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, Tissue_stem_cells:CD326-CD56+: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15
NB14_GACGGCTTCCTCCTAG-1 Neurons:adrenal_medulla_cell_line 0.15 320.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Tissue_stem_cells:CD326-CD56+: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13
NB14_ATCCGAATCCGCGCAA-1 Neurons:adrenal_medulla_cell_line 0.14 305.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, Tissue_stem_cells:CD326-CD56+: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_2lox-22: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.13
NB14_AAACGGGAGGCGATAC-1 Neurons:adrenal_medulla_cell_line 0.17 299.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, Tissue_stem_cells:CD326-CD56+: 0.17, Neurons:Schwann_cell: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Embryonic_stem_cells: 0.17
NB14_TCTGGAATCTGCCCTA-1 Fibroblasts:breast 0.11 297.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.17, MSC: 0.17, Fibroblasts:breast: 0.16, Chondrocytes:MSC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:CRL2097_foreskin: 0.16, iPS_cells:adipose_stem_cells: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Osteoblasts: 0.16
NB14_CAGATCAGTGACCAAG-1 Neurons:adrenal_medulla_cell_line 0.14 297.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.14, Neurons:Schwann_cell: 0.14, Embryonic_stem_cells: 0.14, Tissue_stem_cells:CD326-CD56+: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14
NB14_TTTGGTTGTAAATGAC-1 Neurons:adrenal_medulla_cell_line 0.12 289.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_2lox-5: 0.14
NB14_AGTGGGATCTGAGGGA-1 Neurons:adrenal_medulla_cell_line 0.14 283.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, Embryonic_stem_cells: 0.15, iPS_cells:PDB_2lox-5: 0.15
NB14_CAGATCAGTTTAGCTG-1 Neurons:adrenal_medulla_cell_line 0.11 283.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, Tissue_stem_cells:CD326-CD56+: 0.14, Endothelial_cells:HUVEC:VEGF: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.14, Chondrocytes:MSC-derived: 0.14, Endothelial_cells:HUVEC: 0.13, Endothelial_cells:lymphatic: 0.13, Neurons:Schwann_cell: 0.13
NB14_GACTACAGTAGTAGTA-1 Neurons:adrenal_medulla_cell_line 0.16 279.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, Embryonic_stem_cells: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_2lox-22: 0.19
NB14_ACTTGTTCAGCTGCTG-1 Neurons:adrenal_medulla_cell_line 0.11 277.13
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.14, Neuroepithelial_cell:ESC-derived: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, Embryonic_stem_cells: 0.13, Astrocyte:Embryonic_stem_cell-derived: 0.13, iPS_cells:PDB_2lox-22: 0.12
NB14_AGGGATGCAGACAAAT-1 Neurons:adrenal_medulla_cell_line 0.15 276.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_2lox-22: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15
NB14_GGACAAGCATCTCGCT-1 Neurons:adrenal_medulla_cell_line 0.15 274.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.15, Tissue_stem_cells:CD326-CD56+: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, Embryonic_stem_cells: 0.14
NB14_CGGACTGGTGCACCAC-1 Neurons:adrenal_medulla_cell_line 0.14 272.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, Tissue_stem_cells:CD326-CD56+: 0.12
NB14_CTGGTCTAGCACACAG-1 Neurons:adrenal_medulla_cell_line 0.14 271.02
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, Tissue_stem_cells:CD326-CD56+: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB14_ATCACGATCATGTGGT-1 Neurons:adrenal_medulla_cell_line 0.15 264.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Tissue_stem_cells:CD326-CD56+: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:skin_fibroblast-derived: 0.14
NB14_GTGCATAAGTTCCACA-1 Neurons:adrenal_medulla_cell_line 0.15 263.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, Tissue_stem_cells:CD326-CD56+: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, Embryonic_stem_cells: 0.14
NB14_AAAGATGTCGGCATCG-1 Neurons:adrenal_medulla_cell_line 0.15 259.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, Tissue_stem_cells:CD326-CD56+: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.15, MSC: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15
NB14_CTAGCCTTCACTATTC-1 Neurons:adrenal_medulla_cell_line 0.13 258.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:skin_fibroblast-derived: 0.14
NB14_TCCACACAGTTTAGGA-1 Neurons:adrenal_medulla_cell_line 0.13 257.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.18, Smooth_muscle_cells:bronchial: 0.18, Smooth_muscle_cells:bronchial:vit_D: 0.17, MSC: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:CRL2097_foreskin: 0.17, Tissue_stem_cells:CD326-CD56+: 0.17, iPS_cells:skin_fibroblast: 0.17, Fibroblasts:breast: 0.17
NB14_CACAAACTCTCCGGTT-1 Neurons:adrenal_medulla_cell_line 0.15 253.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Embryonic_stem_cells: 0.14, Tissue_stem_cells:CD326-CD56+: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13
NB14_CGTCAGGTCCAAACAC-1 Neurons:adrenal_medulla_cell_line 0.12 248.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.12, Neuroepithelial_cell:ESC-derived: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, iPS_cells:PDB_1lox-17Puro-10: 0.11, Embryonic_stem_cells: 0.11, Tissue_stem_cells:CD326-CD56+: 0.11, Neurons:ES_cell-derived_neural_precursor: 0.11
NB14_ATGAGGGTCCCGGATG-1 Endothelial_cells:lymphatic:KSHV 0.16 246.77
Raw ScoresEndothelial_cells:lymphatic: 0.3, Endothelial_cells:HUVEC:VEGF: 0.3, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.29, Endothelial_cells:lymphatic:KSHV: 0.29, Endothelial_cells:lymphatic:TNFa_48h: 0.29, Endothelial_cells:HUVEC: 0.29, Endothelial_cells:blood_vessel: 0.29, Endothelial_cells:HUVEC:IL-1b: 0.27, Endothelial_cells:HUVEC:B._anthracis_LT: 0.27, iPS_cells:CRL2097_foreskin: 0.27
NB14_GTAACGTCACCAGATT-1 Neurons:adrenal_medulla_cell_line 0.11 244.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_2lox-5: 0.21
NB14_TTGACTTCAATCTACG-1 Neurons:adrenal_medulla_cell_line 0.16 242.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, Tissue_stem_cells:CD326-CD56+: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.18, MSC: 0.17, Endothelial_cells:HUVEC:VEGF: 0.17, Neurons:Schwann_cell: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17
NB14_CTGATCCAGGATGGAA-1 Neurons:adrenal_medulla_cell_line 0.14 241.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.14, MSC: 0.13, Neurons:Schwann_cell: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Tissue_stem_cells:CD326-CD56+: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13
NB14_CTAGTGAAGCTGAACG-1 Neurons:adrenal_medulla_cell_line 0.15 239.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:skin_fibroblast-derived: 0.15
NB14_GGATTACGTAGCGATG-1 Neurons:adrenal_medulla_cell_line 0.15 238.88
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19, Embryonic_stem_cells: 0.18, Tissue_stem_cells:CD326-CD56+: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_2lox-22: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17
NB13_CTAACTTAGCCGCCTA-1 Neurons:adrenal_medulla_cell_line 0.23 236.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-22: 0.29
NB14_AAGGAGCAGAAACCGC-1 Neurons:adrenal_medulla_cell_line 0.10 230.74
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, Chondrocytes:MSC-derived: 0.15, Smooth_muscle_cells:bronchial: 0.15, Osteoblasts: 0.15, Smooth_muscle_cells:bronchial:vit_D: 0.15, iPS_cells:CRL2097_foreskin: 0.14, Tissue_stem_cells:BM_MSC:BMP2: 0.14
NB14_AGATTGCAGTCATCCA-1 Neurons:adrenal_medulla_cell_line 0.14 230.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, Tissue_stem_cells:CD326-CD56+: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, Embryonic_stem_cells: 0.14
NB14_TAAGCGTAGAGATGAG-1 Neurons:adrenal_medulla_cell_line 0.16 230.31
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Tissue_stem_cells:CD326-CD56+: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_2lox-22: 0.17
NB14_AAAGCAAAGGACAGAA-1 Neurons:adrenal_medulla_cell_line 0.14 228.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Tissue_stem_cells:CD326-CD56+: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, Embryonic_stem_cells: 0.15
NB14_CGTGAGCGTTGAACTC-1 Neurons:adrenal_medulla_cell_line 0.13 224.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, Embryonic_stem_cells: 0.14, Tissue_stem_cells:CD326-CD56+: 0.14
NB14_GTAACTGAGTACGATA-1 Neurons:adrenal_medulla_cell_line 0.12 223.09
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.15, Smooth_muscle_cells:bronchial:vit_D: 0.15, Smooth_muscle_cells:bronchial: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, Smooth_muscle_cells:vascular:IL-17: 0.15, Smooth_muscle_cells:vascular: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.14, iPS_cells:CRL2097_foreskin: 0.14, iPS_cells:adipose_stem_cells: 0.14


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.85e-06
Mean rank of genes in gene set: 4044.37
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RGS5 0.0044652 126 GTEx DepMap Descartes 0.58 439.02
COL1A1 0.0036897 182 GTEx DepMap Descartes 0.71 457.45
POSTN 0.0036784 184 GTEx DepMap Descartes 0.18 227.92
MMP2 0.0028062 329 GTEx DepMap Descartes 0.12 143.11
COL1A2 0.0024567 412 GTEx DepMap Descartes 0.77 491.83
ACTG2 0.0022909 462 GTEx DepMap Descartes 0.02 48.94
PGF 0.0021582 509 GTEx DepMap Descartes 0.06 61.96
TPM2 0.0020322 569 GTEx DepMap Descartes 0.10 227.36
FN1 0.0016008 851 GTEx DepMap Descartes 0.33 144.54
COL3A1 0.0015482 893 GTEx DepMap Descartes 0.36 255.97
IGFBP7 0.0012343 1239 GTEx DepMap Descartes 0.19 486.05
BGN 0.0012075 1289 GTEx DepMap Descartes 0.08 124.94
CNN2 0.0010529 1512 GTEx DepMap Descartes 0.02 30.58
COL5A1 0.0010088 1583 GTEx DepMap Descartes 0.09 38.63
COL4A1 0.0009925 1613 GTEx DepMap Descartes 0.09 53.96
COL15A1 0.0008872 1818 GTEx DepMap Descartes 0.03 17.18
TGFB1 0.0008181 2013 GTEx DepMap Descartes 0.07 102.79
THY1 0.0008003 2052 GTEx DepMap Descartes 0.06 57.35
ACTA2 0.0007822 2098 GTEx DepMap Descartes 0.05 142.89
WNT5A 0.0007343 2242 GTEx DepMap Descartes 0.01 3.97
TNC 0.0006739 2440 GTEx DepMap Descartes 0.06 28.10
COL5A2 0.0005867 2742 GTEx DepMap Descartes 0.10 53.22
COL11A1 0.0005232 2990 GTEx DepMap Descartes 0.04 16.84
MMP11 0.0005146 3030 GTEx DepMap Descartes 0.01 12.50
TPM1 0.0004832 3172 GTEx DepMap Descartes 0.13 126.57
DCN 0.0004397 3385 GTEx DepMap Descartes 0.04 19.63
COL13A1 0.0003946 3599 GTEx DepMap Descartes 0.01 11.68
COL10A1 0.0003766 3708 GTEx DepMap Descartes 0.01 4.63
MYL9 0.0003369 3948 GTEx DepMap Descartes 0.03 48.06
VEGFA 0.0003045 4134 GTEx DepMap Descartes 0.06 19.32
LUM 0.0002989 4176 GTEx DepMap Descartes 0.05 64.58
CNN3 0.0002737 4325 GTEx DepMap Descartes 0.07 151.37
THBS2 0.0002528 4470 GTEx DepMap Descartes 0.05 32.34
TAGLN 0.0002194 4692 GTEx DepMap Descartes 0.03 37.32
TMEM119 0.0001538 5174 GTEx DepMap Descartes 0.01 11.07
TGFBR1 0.0000703 5828 GTEx DepMap Descartes 0.08 49.59
COL12A1 0.0000571 5935 GTEx DepMap Descartes 0.03 10.04
TGFB2 -0.0000508 6950 GTEx DepMap Descartes 0.01 5.05
COL14A1 -0.0000725 7230 GTEx DepMap Descartes 0.02 8.10
IGFBP3 -0.0000761 7274 GTEx DepMap Descartes 0.01 16.09
HOPX -0.0001071 7641 GTEx DepMap Descartes 0.00 2.59
MYLK -0.0001620 8257 GTEx DepMap Descartes 0.01 2.75
ITGA7 -0.0002172 8795 GTEx DepMap Descartes 0.01 4.07
COL8A1 -0.0002342 8959 GTEx DepMap Descartes 0.03 17.44
MYH11 -0.0002928 9432 GTEx DepMap Descartes 0.00 1.74
TGFBR2 -0.0004236 10313 GTEx DepMap Descartes 0.02 9.92
MEF2C -0.0004400 10416 GTEx DepMap Descartes 0.04 16.58
VCAN -0.0007282 11456 GTEx DepMap Descartes 0.06 16.35
THBS1 -0.0008695 11727 GTEx DepMap Descartes 0.03 13.44


Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.10e-04
Mean rank of genes in gene set: 3109.23
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A1 0.0036897 182 GTEx DepMap Descartes 0.71 457.45
COL1A2 0.0024567 412 GTEx DepMap Descartes 0.77 491.83
SPARC 0.0021406 517 GTEx DepMap Descartes 0.27 314.80
CALD1 0.0021119 533 GTEx DepMap Descartes 0.46 344.84
COL3A1 0.0015482 893 GTEx DepMap Descartes 0.36 255.97
COL6A2 0.0014929 943 GTEx DepMap Descartes 0.16 152.72
BGN 0.0012075 1289 GTEx DepMap Descartes 0.08 124.94
PRRX1 0.0007719 2122 GTEx DepMap Descartes 0.03 27.69
DCN 0.0004397 3385 GTEx DepMap Descartes 0.04 19.63
LUM 0.0002989 4176 GTEx DepMap Descartes 0.05 64.58
PDGFRA -0.0000122 6540 GTEx DepMap Descartes 0.01 3.30
LEPR -0.0001676 8328 GTEx DepMap Descartes 0.02 9.09
MGP -0.0006001 11100 GTEx DepMap Descartes 0.03 67.34


Mesenchymal cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that COL1A1+ Mesenchymal were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.47e-03
Mean rank of genes in gene set: 808
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A1 0.0036897 182 GTEx DepMap Descartes 0.71 457.45
COL1A2 0.0024567 412 GTEx DepMap Descartes 0.77 491.83
PDGFRB 0.0008819 1830 GTEx DepMap Descartes 0.03 18.87




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 7006.35
Median rank of genes in gene set: 7774
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHGA 0.0197936 1 GTEx DepMap Descartes 3.32 6803.85
DLK1 0.0169486 3 GTEx DepMap Descartes 1.54 1490.73
STRA6 0.0169388 5 GTEx DepMap Descartes 0.80 1103.42
FAM155A 0.0150706 7 GTEx DepMap Descartes 5.30 2348.91
RET 0.0145396 8 GTEx DepMap Descartes 0.58 405.80
RRM2 0.0116163 16 GTEx DepMap Descartes 0.60 718.97
CACNA2D2 0.0090320 26 GTEx DepMap Descartes 0.28 198.57
CHGB 0.0073304 46 GTEx DepMap Descartes 1.18 2045.75
PRSS12 0.0061842 60 GTEx DepMap Descartes 0.24 199.08
MSI2 0.0049908 91 GTEx DepMap Descartes 1.07 523.05
THSD7A 0.0049290 97 GTEx DepMap Descartes 1.23 478.14
MAGI3 0.0045626 120 GTEx DepMap Descartes 0.49 283.49
RGS5 0.0044652 126 GTEx DepMap Descartes 0.58 439.02
DACH1 0.0042393 141 GTEx DepMap Descartes 0.43 363.75
GATA2 0.0041690 146 GTEx DepMap Descartes 0.35 419.79
ESRRG 0.0041168 151 GTEx DepMap Descartes 0.32 237.09
HAND1 0.0037780 174 GTEx DepMap Descartes 0.17 428.98
CACNA1B 0.0037575 175 GTEx DepMap Descartes 0.67 241.66
PHF21B 0.0037106 180 GTEx DepMap Descartes 0.18 164.18
RBMS3 0.0035984 195 GTEx DepMap Descartes 1.93 889.71
HEY1 0.0035780 200 GTEx DepMap Descartes 0.05 60.81
CEP44 0.0034873 213 GTEx DepMap Descartes 0.20 207.51
DPYSL3 0.0034713 216 GTEx DepMap Descartes 0.45 343.52
EML4 0.0034606 217 GTEx DepMap Descartes 0.37 272.18
RALGDS 0.0032220 250 GTEx DepMap Descartes 0.28 171.82
EML6 0.0031882 257 GTEx DepMap Descartes 0.42 169.87
CYGB 0.0031540 262 GTEx DepMap Descartes 0.16 315.92
INSM2 0.0031321 264 GTEx DepMap Descartes 0.17 241.48
SHC3 0.0029418 297 GTEx DepMap Descartes 0.12 47.60
IRS2 0.0029187 303 GTEx DepMap Descartes 0.19 93.71


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.72e-06
Mean rank of genes in gene set: 5482.7
Median rank of genes in gene set: 4824
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PDIA6 0.0169478 4 GTEx DepMap Descartes 1.76 2883.91
ITPR1 0.0069989 51 GTEx DepMap Descartes 0.22 89.16
SHC1 0.0054258 79 GTEx DepMap Descartes 0.36 415.95
CRABP2 0.0051622 85 GTEx DepMap Descartes 0.09 376.97
SPRY4 0.0048408 101 GTEx DepMap Descartes 0.07 57.15
ACADVL 0.0047749 107 GTEx DepMap Descartes 0.32 496.53
SHROOM3 0.0043774 133 GTEx DepMap Descartes 0.09 33.58
FLNA 0.0043616 134 GTEx DepMap Descartes 0.26 120.95
COL1A1 0.0036897 182 GTEx DepMap Descartes 0.71 457.45
POSTN 0.0036784 184 GTEx DepMap Descartes 0.18 227.92
PTPRG 0.0036757 185 GTEx DepMap Descartes 0.39 165.28
SVIL 0.0036525 189 GTEx DepMap Descartes 0.20 95.98
MEST 0.0035499 204 GTEx DepMap Descartes 0.21 346.59
LGALS1 0.0034835 215 GTEx DepMap Descartes 0.17 1135.55
TMED9 0.0034512 220 GTEx DepMap Descartes 0.15 265.12
MMP2 0.0028062 329 GTEx DepMap Descartes 0.12 143.11
SSBP4 0.0027670 338 GTEx DepMap Descartes 0.24 528.94
FZD2 0.0027124 343 GTEx DepMap Descartes 0.02 21.15
PTBP1 0.0024729 406 GTEx DepMap Descartes 0.19 156.45
TPBG 0.0023069 453 GTEx DepMap Descartes 0.02 12.03
SQSTM1 0.0022240 486 GTEx DepMap Descartes 0.19 248.04
GDF15 0.0021861 498 GTEx DepMap Descartes 0.03 112.76
NFIC 0.0021669 504 GTEx DepMap Descartes 0.15 61.90
PTPRK 0.0021596 508 GTEx DepMap Descartes 0.39 NA
CRTAP 0.0021523 512 GTEx DepMap Descartes 0.06 37.51
SPARC 0.0021406 517 GTEx DepMap Descartes 0.27 314.80
CALD1 0.0021119 533 GTEx DepMap Descartes 0.46 344.84
SERPINH1 0.0020843 546 GTEx DepMap Descartes 0.05 58.12
TPM2 0.0020322 569 GTEx DepMap Descartes 0.10 227.36
STAT3 0.0019942 588 GTEx DepMap Descartes 0.20 153.21


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.54e-01
Mean rank of genes in gene set: 6911.06
Median rank of genes in gene set: 8808.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PDE10A 0.0133388 10 GTEx DepMap Descartes 1.14 511.79
IGF1R 0.0038925 166 GTEx DepMap Descartes 0.53 170.96
FREM2 0.0022173 489 GTEx DepMap Descartes 0.02 4.89
FDXR 0.0020164 578 GTEx DepMap Descartes 0.05 80.19
DNER 0.0018809 650 GTEx DepMap Descartes 0.10 137.20
FDPS 0.0017325 743 GTEx DepMap Descartes 0.17 318.82
SCAP 0.0017287 746 GTEx DepMap Descartes 0.12 106.38
SCARB1 0.0017204 754 GTEx DepMap Descartes 0.09 63.76
ERN1 0.0015148 924 GTEx DepMap Descartes 0.04 21.64
JAKMIP2 0.0013120 1157 GTEx DepMap Descartes 0.20 87.49
SH3PXD2B 0.0013043 1167 GTEx DepMap Descartes 0.07 33.50
GRAMD1B 0.0008748 1849 GTEx DepMap Descartes 0.05 22.39
INHA 0.0004392 3388 GTEx DepMap Descartes 0.00 12.69
STAR 0.0000024 6420 GTEx DepMap Descartes 0.00 0.62
GSTA4 -0.0001058 7627 GTEx DepMap Descartes 0.07 165.40
CYB5B -0.0001151 7727 GTEx DepMap Descartes 0.06 60.55
DHCR7 -0.0001522 8140 GTEx DepMap Descartes 0.01 10.72
FDX1 -0.0002098 8725 GTEx DepMap Descartes 0.01 12.82
TM7SF2 -0.0002270 8892 GTEx DepMap Descartes 0.03 52.01
BAIAP2L1 -0.0002681 9244 GTEx DepMap Descartes 0.01 5.69
NPC1 -0.0002893 9405 GTEx DepMap Descartes 0.04 32.08
HMGCR -0.0003537 9866 GTEx DepMap Descartes 0.05 41.84
DHCR24 -0.0003579 9898 GTEx DepMap Descartes 0.03 18.56
POR -0.0003884 10093 GTEx DepMap Descartes 0.03 37.26
LDLR -0.0004603 10510 GTEx DepMap Descartes 0.01 6.69
SLC16A9 -0.0005036 10743 GTEx DepMap Descartes 0.03 22.74
PAPSS2 -0.0005714 10999 GTEx DepMap Descartes 0.01 8.93
APOC1 -0.0006880 11333 GTEx DepMap Descartes 0.04 212.45
SH3BP5 -0.0007278 11455 GTEx DepMap Descartes 0.02 27.29
MSMO1 -0.0008161 11632 GTEx DepMap Descartes 0.02 27.46


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10955.71
Median rank of genes in gene set: 12399
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RPH3A 0.0031260 267 GTEx DepMap Descartes 0.05 37.81
NTRK1 0.0010863 1460 GTEx DepMap Descartes 0.09 111.25
CNKSR2 0.0006713 2452 GTEx DepMap Descartes 0.22 109.82
ISL1 0.0003747 3722 GTEx DepMap Descartes 0.32 545.03
GAL 0.0001901 4920 GTEx DepMap Descartes 0.25 1249.44
EYA1 -0.0001206 7781 GTEx DepMap Descartes 0.30 288.57
MAB21L1 -0.0003386 9767 GTEx DepMap Descartes 0.04 56.88
GREM1 -0.0004890 10660 GTEx DepMap Descartes 0.00 0.00
MAB21L2 -0.0008184 11637 GTEx DepMap Descartes 0.03 56.75
SYNPO2 -0.0010752 11979 GTEx DepMap Descartes 0.14 29.90
MAP1B -0.0011589 12048 GTEx DepMap Descartes 0.48 159.61
CNTFR -0.0012581 12113 GTEx DepMap Descartes 0.02 36.38
PTCHD1 -0.0013030 12139 GTEx DepMap Descartes 0.01 3.26
REEP1 -0.0013738 12203 GTEx DepMap Descartes 0.02 19.20
SLC6A2 -0.0014598 12241 GTEx DepMap Descartes 0.03 29.09
RGMB -0.0015034 12256 GTEx DepMap Descartes 0.05 45.82
FAT3 -0.0016154 12300 GTEx DepMap Descartes 0.01 1.46
PLXNA4 -0.0016767 12317 GTEx DepMap Descartes 0.02 5.02
MLLT11 -0.0017887 12352 GTEx DepMap Descartes 0.13 230.81
TMEFF2 -0.0018778 12368 GTEx DepMap Descartes 0.01 4.06
ANKFN1 -0.0020601 12399 GTEx DepMap Descartes 0.01 5.13
HS3ST5 -0.0020949 12408 GTEx DepMap Descartes 0.06 50.99
TUBB2A -0.0021334 12415 GTEx DepMap Descartes 0.05 114.00
GAP43 -0.0021974 12421 GTEx DepMap Descartes 0.06 119.66
SLC44A5 -0.0022902 12436 GTEx DepMap Descartes 0.03 13.58
KCNB2 -0.0023739 12446 GTEx DepMap Descartes 0.11 87.69
ELAVL2 -0.0025011 12463 GTEx DepMap Descartes 0.07 64.24
BASP1 -0.0025104 12465 GTEx DepMap Descartes 0.10 211.09
EPHA6 -0.0026143 12475 GTEx DepMap Descartes 0.06 20.47
EYA4 -0.0028666 12495 GTEx DepMap Descartes 0.07 43.35


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.40e-01
Mean rank of genes in gene set: 6652.63
Median rank of genes in gene set: 6287
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MYRIP 0.0023291 446 GTEx DepMap Descartes 0.12 77.36
PLVAP 0.0012644 1209 GTEx DepMap Descartes 0.03 34.69
HYAL2 0.0010028 1591 GTEx DepMap Descartes 0.04 37.86
TMEM88 0.0007874 2083 GTEx DepMap Descartes 0.03 129.54
SHANK3 0.0007856 2089 GTEx DepMap Descartes 0.03 14.17
KDR 0.0006637 2479 GTEx DepMap Descartes 0.01 6.03
EHD3 0.0003916 3620 GTEx DepMap Descartes 0.01 9.66
FLT4 0.0003355 3957 GTEx DepMap Descartes 0.01 5.09
NOTCH4 0.0003089 4105 GTEx DepMap Descartes 0.02 7.71
CDH5 0.0003075 4112 GTEx DepMap Descartes 0.01 7.00
ESM1 0.0002447 4517 GTEx DepMap Descartes 0.00 7.46
TIE1 0.0002101 4760 GTEx DepMap Descartes 0.01 7.26
RASIP1 0.0002078 4785 GTEx DepMap Descartes 0.01 5.97
ROBO4 0.0001939 4890 GTEx DepMap Descartes 0.01 4.75
NPR1 0.0001784 4993 GTEx DepMap Descartes 0.00 2.18
CLDN5 0.0001274 5365 GTEx DepMap Descartes 0.01 11.29
MMRN2 0.0000905 5649 GTEx DepMap Descartes 0.00 4.78
F8 0.0000662 5859 GTEx DepMap Descartes 0.00 0.98
IRX3 0.0000312 6147 GTEx DepMap Descartes 0.00 3.98
CRHBP 0.0000017 6427 GTEx DepMap Descartes 0.00 1.72
KANK3 -0.0000390 6810 GTEx DepMap Descartes 0.00 4.76
CALCRL -0.0000767 7286 GTEx DepMap Descartes 0.01 7.43
SLCO2A1 -0.0001008 7561 GTEx DepMap Descartes 0.00 2.63
PODXL -0.0001166 7740 GTEx DepMap Descartes 0.02 14.25
CYP26B1 -0.0001320 7924 GTEx DepMap Descartes 0.00 1.35
BTNL9 -0.0001574 8205 GTEx DepMap Descartes 0.00 1.69
GALNT15 -0.0001660 8309 GTEx DepMap Descartes 0.00 NA
RAMP2 -0.0002445 9042 GTEx DepMap Descartes 0.02 87.78
SHE -0.0002577 9166 GTEx DepMap Descartes 0.00 0.76
ID1 -0.0004002 10172 GTEx DepMap Descartes 0.01 37.65


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.21e-01
Mean rank of genes in gene set: 5637.5
Median rank of genes in gene set: 6237.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ISLR 0.0056121 75 GTEx DepMap Descartes 0.11 203.91
COL1A1 0.0036897 182 GTEx DepMap Descartes 0.71 457.45
POSTN 0.0036784 184 GTEx DepMap Descartes 0.18 227.92
CD248 0.0034068 225 GTEx DepMap Descartes 0.05 83.51
COL1A2 0.0024567 412 GTEx DepMap Descartes 0.77 491.83
PCOLCE 0.0019153 627 GTEx DepMap Descartes 0.27 671.47
COL3A1 0.0015482 893 GTEx DepMap Descartes 0.36 255.97
COL6A3 0.0013348 1126 GTEx DepMap Descartes 0.11 40.36
GLI2 0.0012038 1296 GTEx DepMap Descartes 0.02 10.13
SFRP2 0.0011400 1389 GTEx DepMap Descartes 0.03 59.84
ACTA2 0.0007822 2098 GTEx DepMap Descartes 0.05 142.89
PRRX1 0.0007719 2122 GTEx DepMap Descartes 0.03 27.69
PCDH18 0.0006914 2373 GTEx DepMap Descartes 0.01 4.32
EDNRA 0.0006047 2685 GTEx DepMap Descartes 0.03 19.48
DCN 0.0004397 3385 GTEx DepMap Descartes 0.04 19.63
CDH11 0.0004155 3487 GTEx DepMap Descartes 0.06 30.69
ELN 0.0003291 3994 GTEx DepMap Descartes 0.05 49.62
LUM 0.0002989 4176 GTEx DepMap Descartes 0.05 64.58
ABCC9 0.0001811 4979 GTEx DepMap Descartes 0.01 3.22
LOX 0.0001643 5113 GTEx DepMap Descartes 0.01 7.12
ADAMTSL3 0.0000706 5824 GTEx DepMap Descartes 0.01 6.32
COL12A1 0.0000571 5935 GTEx DepMap Descartes 0.03 10.04
PDGFRA -0.0000122 6540 GTEx DepMap Descartes 0.01 3.30
DKK2 -0.0000140 6556 GTEx DepMap Descartes 0.01 10.05
COL27A1 -0.0000253 6686 GTEx DepMap Descartes 0.02 5.38
SCARA5 -0.0000368 6788 GTEx DepMap Descartes 0.00 1.06
ITGA11 -0.0000436 6858 GTEx DepMap Descartes 0.01 2.39
BICC1 -0.0000636 7112 GTEx DepMap Descartes 0.10 63.39
IGFBP3 -0.0000761 7274 GTEx DepMap Descartes 0.01 16.09
ADAMTS2 -0.0000771 7287 GTEx DepMap Descartes 0.04 18.88


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.04e-01
Mean rank of genes in gene set: 6589.34
Median rank of genes in gene set: 9864.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHGA 0.0197936 1 GTEx DepMap Descartes 3.32 6803.85
FAM155A 0.0150706 7 GTEx DepMap Descartes 5.30 2348.91
ST18 0.0130227 11 GTEx DepMap Descartes 0.51 354.01
FGF14 0.0082252 36 GTEx DepMap Descartes 2.68 861.47
SLC35F3 0.0079604 37 GTEx DepMap Descartes 0.34 397.51
PCSK2 0.0075864 41 GTEx DepMap Descartes 0.41 351.78
SLC18A1 0.0073638 45 GTEx DepMap Descartes 0.29 394.49
CHGB 0.0073304 46 GTEx DepMap Descartes 1.18 2045.75
C1QL1 0.0054629 78 GTEx DepMap Descartes 0.17 485.19
MGAT4C 0.0034445 221 GTEx DepMap Descartes 0.28 43.18
EML6 0.0031882 257 GTEx DepMap Descartes 0.42 169.87
SLC24A2 0.0020566 559 GTEx DepMap Descartes 0.05 18.50
ARC 0.0015610 883 GTEx DepMap Descartes 0.07 101.27
GCH1 0.0010517 1514 GTEx DepMap Descartes 0.14 200.77
PACRG 0.0009898 1616 GTEx DepMap Descartes 0.12 288.79
DGKK 0.0008425 1928 GTEx DepMap Descartes 0.01 5.59
HTATSF1 0.0007916 2073 GTEx DepMap Descartes 0.09 124.61
LAMA3 0.0003210 4041 GTEx DepMap Descartes 0.03 11.43
PENK -0.0002459 9058 GTEx DepMap Descartes 0.00 6.75
SORCS3 -0.0004909 10671 GTEx DepMap Descartes 0.00 1.95
UNC80 -0.0005340 10868 GTEx DepMap Descartes 0.18 52.23
CNTN3 -0.0005512 10924 GTEx DepMap Descartes 0.00 1.51
KSR2 -0.0009174 11802 GTEx DepMap Descartes 0.05 10.47
CDH12 -0.0010124 11920 GTEx DepMap Descartes 0.01 4.74
TBX20 -0.0011781 12064 GTEx DepMap Descartes 0.01 12.49
TIAM1 -0.0012614 12116 GTEx DepMap Descartes 0.14 64.04
CCSER1 -0.0013277 12157 GTEx DepMap Descartes 0.45 NA
AGBL4 -0.0013501 12178 GTEx DepMap Descartes 0.18 161.50
ROBO1 -0.0013647 12194 GTEx DepMap Descartes 0.41 168.16
SPOCK3 -0.0014473 12235 GTEx DepMap Descartes 0.03 45.09


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.29e-01
Mean rank of genes in gene set: 7260.21
Median rank of genes in gene set: 7391
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SELENBP1 0.0022309 483 GTEx DepMap Descartes 0.02 24.62
DENND4A 0.0011903 1317 GTEx DepMap Descartes 0.22 101.81
SLC25A37 0.0010892 1456 GTEx DepMap Descartes 0.06 43.41
ANK1 0.0009231 1742 GTEx DepMap Descartes 0.09 36.86
TMCC2 0.0005295 2963 GTEx DepMap Descartes 0.02 17.70
GCLC 0.0002644 4387 GTEx DepMap Descartes 0.05 59.31
CPOX 0.0001947 4886 GTEx DepMap Descartes 0.01 21.02
EPB41 0.0001717 5052 GTEx DepMap Descartes 0.13 76.35
SLC4A1 0.0001447 5233 GTEx DepMap Descartes 0.00 1.09
TRAK2 0.0000852 5692 GTEx DepMap Descartes 0.03 18.95
XPO7 0.0000763 5768 GTEx DepMap Descartes 0.08 64.07
SPECC1 0.0000112 6329 GTEx DepMap Descartes 0.01 3.18
ALAS2 -0.0000594 7061 GTEx DepMap Descartes 0.00 0.00
BLVRB -0.0000631 7106 GTEx DepMap Descartes 0.01 27.23
MICAL2 -0.0000867 7391 GTEx DepMap Descartes 0.02 7.15
CAT -0.0000969 7512 GTEx DepMap Descartes 0.02 30.16
GYPC -0.0001168 7743 GTEx DepMap Descartes 0.00 11.76
RGS6 -0.0001442 8040 GTEx DepMap Descartes 0.00 1.73
SLC25A21 -0.0002818 9348 GTEx DepMap Descartes 0.00 1.73
MARCH3 -0.0003302 9709 GTEx DepMap Descartes 0.04 NA
SPTB -0.0004136 10253 GTEx DepMap Descartes 0.01 2.83
SNCA -0.0004349 10389 GTEx DepMap Descartes 0.03 30.67
RHD -0.0004491 10460 GTEx DepMap Descartes 0.00 2.68
FECH -0.0004825 10627 GTEx DepMap Descartes 0.01 7.65
RAPGEF2 -0.0007503 11501 GTEx DepMap Descartes 0.13 65.29
ABCB10 -0.0008378 11673 GTEx DepMap Descartes 0.01 12.39
TFR2 -0.0008604 11714 GTEx DepMap Descartes 0.03 42.69
SOX6 -0.0015836 12287 GTEx DepMap Descartes 0.05 23.02
TSPAN5 -0.0022097 12424 GTEx DepMap Descartes 0.07 53.84
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 7664.53
Median rank of genes in gene set: 9065.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SFMBT2 0.0031138 268 GTEx DepMap Descartes 0.16 72.48
ITPR2 0.0023741 439 GTEx DepMap Descartes 0.13 41.72
MARCH1 0.0022407 478 GTEx DepMap Descartes 0.11 NA
CST3 0.0009987 1605 GTEx DepMap Descartes 0.10 124.78
CTSB 0.0008240 1995 GTEx DepMap Descartes 0.13 142.96
PTPRE 0.0008006 2051 GTEx DepMap Descartes 0.07 37.82
RGL1 0.0005964 2707 GTEx DepMap Descartes 0.09 68.36
LGMN 0.0003120 4084 GTEx DepMap Descartes 0.04 69.27
MERTK 0.0002573 4440 GTEx DepMap Descartes 0.01 12.60
TGFBI 0.0001903 4918 GTEx DepMap Descartes 0.03 22.59
CTSC 0.0000767 5761 GTEx DepMap Descartes 0.02 12.73
ADAP2 0.0000412 6061 GTEx DepMap Descartes 0.01 16.83
CPVL 0.0000393 6073 GTEx DepMap Descartes 0.02 33.56
MSR1 -0.0000007 6444 GTEx DepMap Descartes 0.03 30.60
AXL -0.0002007 8657 GTEx DepMap Descartes 0.01 12.00
IFNGR1 -0.0002055 8696 GTEx DepMap Descartes 0.04 59.95
MS4A4A -0.0002139 8770 GTEx DepMap Descartes 0.00 6.30
CSF1R -0.0002258 8872 GTEx DepMap Descartes 0.00 1.63
SLC1A3 -0.0002358 8977 GTEx DepMap Descartes 0.01 7.14
CD163 -0.0002557 9154 GTEx DepMap Descartes 0.00 1.96
CTSD -0.0002606 9187 GTEx DepMap Descartes 0.13 261.61
ATP8B4 -0.0002707 9261 GTEx DepMap Descartes 0.00 2.01
CTSS -0.0003105 9562 GTEx DepMap Descartes 0.01 7.61
SLC9A9 -0.0003191 9628 GTEx DepMap Descartes 0.02 26.47
FGD2 -0.0003362 9751 GTEx DepMap Descartes 0.00 0.32
HRH1 -0.0003407 9787 GTEx DepMap Descartes 0.01 5.14
WWP1 -0.0003650 9941 GTEx DepMap Descartes 0.04 28.69
SLCO2B1 -0.0003824 10056 GTEx DepMap Descartes 0.01 2.87
CYBB -0.0004160 10268 GTEx DepMap Descartes 0.00 0.00
FGL2 -0.0004258 10326 GTEx DepMap Descartes 0.00 0.00


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 7742.36
Median rank of genes in gene set: 8079.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ERBB4 0.0192517 2 GTEx DepMap Descartes 4.42 1593.77
NRXN3 0.0033081 238 GTEx DepMap Descartes 0.24 110.40
STARD13 0.0017572 733 GTEx DepMap Descartes 0.09 54.10
PTN 0.0016322 817 GTEx DepMap Descartes 0.13 350.67
LAMC1 0.0014763 961 GTEx DepMap Descartes 0.11 51.37
DST 0.0011894 1319 GTEx DepMap Descartes 0.76 138.66
FIGN 0.0010572 1505 GTEx DepMap Descartes 0.10 42.72
PLCE1 0.0008043 2044 GTEx DepMap Descartes 0.05 12.29
COL5A2 0.0005867 2742 GTEx DepMap Descartes 0.10 53.22
SCN7A 0.0005567 2856 GTEx DepMap Descartes 0.07 42.18
OLFML2A 0.0003571 3827 GTEx DepMap Descartes 0.01 3.47
COL18A1 0.0001872 4940 GTEx DepMap Descartes 0.09 48.00
MPZ 0.0001079 5512 GTEx DepMap Descartes 0.00 11.43
ADAMTS5 0.0000805 5733 GTEx DepMap Descartes 0.01 1.81
SFRP1 -0.0000466 6893 GTEx DepMap Descartes 0.04 32.06
EDNRB -0.0000476 6907 GTEx DepMap Descartes 0.00 1.25
HMGA2 -0.0000612 7078 GTEx DepMap Descartes 0.00 1.06
GAS7 -0.0000806 7327 GTEx DepMap Descartes 0.02 11.08
GRIK3 -0.0000883 7412 GTEx DepMap Descartes 0.01 2.17
LAMA4 -0.0001188 7763 GTEx DepMap Descartes 0.02 8.48
NRXN1 -0.0001336 7932 GTEx DepMap Descartes 0.48 195.21
MDGA2 -0.0001357 7956 GTEx DepMap Descartes 0.00 0.00
ERBB3 -0.0001572 8203 GTEx DepMap Descartes 0.00 2.78
PLP1 -0.0002035 8683 GTEx DepMap Descartes 0.00 0.47
PTPRZ1 -0.0003227 9656 GTEx DepMap Descartes 0.00 0.73
VIM -0.0003230 9659 GTEx DepMap Descartes 0.14 210.72
LAMB1 -0.0004220 10299 GTEx DepMap Descartes 0.12 79.80
GFRA3 -0.0004861 10649 GTEx DepMap Descartes 0.03 58.24
COL25A1 -0.0005436 10900 GTEx DepMap Descartes 0.00 0.53
SLC35F1 -0.0006305 11186 GTEx DepMap Descartes 0.01 5.16


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.10e-01
Mean rank of genes in gene set: 6425.07
Median rank of genes in gene set: 6539
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MCTP1 0.0050385 87 GTEx DepMap Descartes 0.20 162.21
FLNA 0.0043616 134 GTEx DepMap Descartes 0.26 120.95
MYH9 0.0027806 336 GTEx DepMap Descartes 0.14 77.11
TPM4 0.0023819 437 GTEx DepMap Descartes 0.17 133.13
VCL 0.0015096 927 GTEx DepMap Descartes 0.08 38.60
LIMS1 0.0010556 1507 GTEx DepMap Descartes 0.11 104.67
ACTB 0.0010535 1511 GTEx DepMap Descartes 1.52 2886.06
TUBB1 0.0010009 1596 GTEx DepMap Descartes 0.00 1.97
ANGPT1 0.0009883 1618 GTEx DepMap Descartes 0.02 17.44
ZYX 0.0009425 1704 GTEx DepMap Descartes 0.06 106.24
TGFB1 0.0008181 2013 GTEx DepMap Descartes 0.07 102.79
GSN 0.0006837 2399 GTEx DepMap Descartes 0.06 37.35
MED12L 0.0006739 2441 GTEx DepMap Descartes 0.08 28.51
GP1BA 0.0006074 2676 GTEx DepMap Descartes 0.01 16.64
STON2 0.0005014 3090 GTEx DepMap Descartes 0.04 37.18
P2RX1 0.0003265 4012 GTEx DepMap Descartes 0.00 3.60
ITGA2B 0.0002921 4215 GTEx DepMap Descartes 0.02 18.59
SPN 0.0002694 4352 GTEx DepMap Descartes 0.01 6.34
PSTPIP2 0.0002457 4510 GTEx DepMap Descartes 0.01 10.39
TLN1 0.0002235 4663 GTEx DepMap Descartes 0.03 14.24
LTBP1 0.0000791 5741 GTEx DepMap Descartes 0.02 10.59
RAP1B 0.0000213 6237 GTEx DepMap Descartes 0.06 19.60
ARHGAP6 -0.0000122 6539 GTEx DepMap Descartes 0.01 6.40
FERMT3 -0.0000292 6716 GTEx DepMap Descartes 0.01 11.13
ITGB3 -0.0001018 7572 GTEx DepMap Descartes 0.00 0.00
STOM -0.0001163 7736 GTEx DepMap Descartes 0.01 12.88
TRPC6 -0.0001396 7998 GTEx DepMap Descartes 0.00 2.08
MYLK -0.0001620 8257 GTEx DepMap Descartes 0.01 2.75
FLI1 -0.0002034 8682 GTEx DepMap Descartes 0.02 11.80
CD84 -0.0002278 8904 GTEx DepMap Descartes 0.00 2.07


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 7764.83
Median rank of genes in gene set: 9852
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RAP1GAP2 0.0079040 38 GTEx DepMap Descartes 0.92 506.60
TOX 0.0028182 326 GTEx DepMap Descartes 0.64 662.76
ARID5B 0.0017972 707 GTEx DepMap Descartes 0.09 46.54
FOXP1 0.0016848 784 GTEx DepMap Descartes 0.56 239.50
PLEKHA2 0.0013744 1082 GTEx DepMap Descartes 0.04 30.41
IKZF1 0.0012076 1287 GTEx DepMap Descartes 0.02 16.82
MBNL1 0.0010852 1463 GTEx DepMap Descartes 0.22 148.24
MCTP2 0.0010667 1489 GTEx DepMap Descartes 0.02 10.66
ETS1 0.0008682 1864 GTEx DepMap Descartes 0.05 34.66
CELF2 0.0008241 1994 GTEx DepMap Descartes 0.10 50.27
WIPF1 0.0004944 3118 GTEx DepMap Descartes 0.10 80.16
CCND3 0.0002806 4291 GTEx DepMap Descartes 0.05 78.27
NCALD 0.0001990 4860 GTEx DepMap Descartes 0.07 69.28
ITPKB 0.0000899 5655 GTEx DepMap Descartes 0.01 7.39
LCP1 0.0000577 5926 GTEx DepMap Descartes 0.01 12.81
ABLIM1 -0.0000365 6783 GTEx DepMap Descartes 0.08 35.90
MSN -0.0002122 8755 GTEx DepMap Descartes 0.02 19.77
ARHGDIB -0.0002333 8953 GTEx DepMap Descartes 0.00 14.47
B2M -0.0002468 9069 GTEx DepMap Descartes 0.32 531.16
PITPNC1 -0.0002850 9373 GTEx DepMap Descartes 0.22 121.96
GNG2 -0.0003411 9791 GTEx DepMap Descartes 0.15 151.93
RCSD1 -0.0003605 9913 GTEx DepMap Descartes 0.00 2.19
CCL5 -0.0003680 9955 GTEx DepMap Descartes 0.00 3.81
DOCK10 -0.0003756 10011 GTEx DepMap Descartes 0.10 57.16
LEF1 -0.0003787 10031 GTEx DepMap Descartes 0.00 2.33
SAMD3 -0.0003819 10052 GTEx DepMap Descartes 0.00 1.62
PRKCH -0.0004751 10589 GTEx DepMap Descartes 0.02 15.86
ANKRD44 -0.0005144 10790 GTEx DepMap Descartes 0.08 44.81
SP100 -0.0005948 11079 GTEx DepMap Descartes 0.01 7.52
EVL -0.0006165 11145 GTEx DepMap Descartes 0.27 265.69


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.99e-03
Mean rank of genes in gene set: 1326.33
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A1 0.0036897 182 GTEx DepMap Descartes 0.71 457.45
COL1A2 0.0024567 412 GTEx DepMap Descartes 0.77 491.83
DCN 0.0004397 3385 GTEx DepMap Descartes 0.04 19.63


Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.37e-02
Mean rank of genes in gene set: 1197
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
KCNH2 0.0043547 135 GTEx DepMap Descartes 0.30 274.48
PRDX2 0.0007288 2259 GTEx DepMap Descartes 0.24 584.69


ILC: ILC (curated markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.29e-02
Mean rank of genes in gene set: 2426
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TLE1 0.0043539 136 GTEx DepMap Descartes 0.18 188.54
S100A13 0.0032732 245 GTEx DepMap Descartes 0.07 126.44
AREG -0.0000470 6897 GTEx DepMap Descartes 0.00 0.00