Program: 39. Neuroblastoma: Adrenergic II (pre-neuronal like).

Program: 39. Neuroblastoma: Adrenergic II (pre-neuronal like).



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 NEFL 0.0176205 neurofilament light chain GTEx DepMap Descartes 10.26 847.86
2 NNAT 0.0176045 neuronatin GTEx DepMap Descartes 21.81 5568.78
3 BASP1 0.0157331 brain abundant membrane attached signal protein 1 GTEx DepMap Descartes 22.17 3551.72
4 NEFM 0.0156529 neurofilament medium chain GTEx DepMap Descartes 5.15 502.73
5 ELAVL2 0.0137525 ELAV like RNA binding protein 2 GTEx DepMap Descartes 4.90 379.38
6 TUBB2A 0.0136470 tubulin beta 2A class IIa GTEx DepMap Descartes 23.94 4130.33
7 CCND1 0.0132328 cyclin D1 GTEx DepMap Descartes 11.78 931.46
8 MAP1B 0.0120524 microtubule associated protein 1B GTEx DepMap Descartes 30.10 678.27
9 TUBB2B 0.0120385 tubulin beta 2B class IIb GTEx DepMap Descartes 33.41 4911.03
10 VSTM2L 0.0118325 V-set and transmembrane domain containing 2 like GTEx DepMap Descartes 1.27 216.92
11 GAP43 0.0116845 growth associated protein 43 GTEx DepMap Descartes 19.14 2862.35
12 PTN 0.0116536 pleiotrophin GTEx DepMap Descartes 4.79 1010.25
13 KIF21A 0.0115873 kinesin family member 21A GTEx DepMap Descartes 4.45 193.39
14 STMN2 0.0115029 stathmin 2 GTEx DepMap Descartes 79.25 11503.56
15 MARCKSL1 0.0109211 MARCKS like 1 GTEx DepMap Descartes 23.40 4444.88
16 PCSK1N 0.0106874 proprotein convertase subtilisin/kexin type 1 inhibitor GTEx DepMap Descartes 15.61 4456.82
17 FGF13 0.0106064 fibroblast growth factor 13 GTEx DepMap Descartes 1.53 23.86
18 MLLT11 0.0105298 MLLT11 transcription factor 7 cofactor GTEx DepMap Descartes 28.77 3341.22
19 VSNL1 0.0103737 visinin like 1 GTEx DepMap Descartes 4.16 473.80
20 CRMP1 0.0103358 collapsin response mediator protein 1 GTEx DepMap Descartes 4.52 411.14
21 MAB21L1 0.0102853 mab-21 like 1 GTEx DepMap Descartes 2.97 322.34
22 NRXN1 0.0102540 neurexin 1 GTEx DepMap Descartes 1.39 45.21
23 DOK6 0.0102090 docking protein 6 GTEx DepMap Descartes 0.51 18.61
24 YWHAQ 0.0101248 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta GTEx DepMap Descartes 17.00 2157.91
25 TUBA1A 0.0099876 tubulin alpha 1a GTEx DepMap Descartes 99.80 14028.06
26 STMN1 0.0094616 stathmin 1 GTEx DepMap Descartes 44.37 4278.99
27 ATAT1 0.0092786 alpha tubulin acetyltransferase 1 GTEx DepMap Descartes 2.75 315.04
28 CHN1 0.0091067 chimerin 1 GTEx DepMap Descartes 1.43 122.48
29 PTMS 0.0090094 parathymosin GTEx DepMap Descartes 12.14 2994.24
30 NREP 0.0089724 neuronal regeneration related protein GTEx DepMap Descartes 11.98 NA
31 APLP1 0.0089672 amyloid beta precursor like protein 1 GTEx DepMap Descartes 3.41 434.54
32 ST6GALNAC5 0.0088548 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 GTEx DepMap Descartes 0.96 64.78
33 VAMP2 0.0087961 vesicle associated membrane protein 2 GTEx DepMap Descartes 15.63 2179.50
34 MAPT 0.0087486 microtubule associated protein tau GTEx DepMap Descartes 5.19 207.95
35 INA 0.0087028 internexin neuronal intermediate filament protein alpha GTEx DepMap Descartes 2.07 179.62
36 NSG1 0.0086282 neuronal vesicle trafficking associated 1 GTEx DepMap Descartes 3.74 NA
37 YWHAE 0.0085874 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon GTEx DepMap Descartes 16.00 1966.56
38 KCNIP4 0.0085295 potassium voltage-gated channel interacting protein 4 GTEx DepMap Descartes 0.79 105.82
39 OLFM1 0.0085241 olfactomedin 1 GTEx DepMap Descartes 3.12 339.47
40 NXPH1 0.0084768 neurexophilin 1 GTEx DepMap Descartes 2.62 269.62
41 ZFHX3 0.0084658 zinc finger homeobox 3 GTEx DepMap Descartes 4.41 82.08
42 UCHL1 0.0084638 ubiquitin C-terminal hydrolase L1 GTEx DepMap Descartes 12.87 2221.59
43 RAC3 0.0084605 Rac family small GTPase 3 GTEx DepMap Descartes 4.32 1103.04
44 TRIB2 0.0084498 tribbles pseudokinase 2 GTEx DepMap Descartes 2.20 170.99
45 PSD3 0.0084275 pleckstrin and Sec7 domain containing 3 GTEx DepMap Descartes 1.25 35.07
46 SYBU 0.0083449 syntabulin GTEx DepMap Descartes 1.32 120.79
47 MAP1LC3A 0.0083227 microtubule associated protein 1 light chain 3 alpha GTEx DepMap Descartes 5.88 1767.82
48 CALM2 0.0083141 calmodulin 2 GTEx DepMap Descartes 57.45 3570.35
49 STMN3 0.0082716 stathmin 3 GTEx DepMap Descartes 4.31 518.68
50 PAFAH1B3 0.0082353 platelet activating factor acetylhydrolase 1b catalytic subunit 3 GTEx DepMap Descartes 4.15 1049.06


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UMAP plots showing activity of gene expression program identified in GEP 39. Neuroblastoma: Adrenergic II (pre-neuronal like):

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 39. Neuroblastoma: Adrenergic II (pre-neuronal like):
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_IMMATURE_NEURONS 5.39e-27 69.97 36.55 1.65e-24 3.62e-24
20BASP1, TUBB2A, MAP1B, TUBB2B, GAP43, STMN2, MARCKSL1, PCSK1N, CRMP1, NRXN1, TUBA1A, STMN1, APLP1, VAMP2, INA, NSG1, UCHL1, CALM2, STMN3, PAFAH1B3
 139
HU_FETAL_RETINA_AMACRINE 1.02e-17 75.77 34.04 6.87e-16 6.87e-15
12NNAT, TUBB2A, TUBB2B, STMN2, MARCKSL1, MLLT11, MAB21L1, NRXN1, STMN1, NREP, INA, TRIB2
 64
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_GLOBOSE_BASAL_CELLS 6.24e-11 72.47 25.33 2.01e-09 4.19e-08
7MAP1B, TUBB2B, STMN2, MARCKSL1, TUBA1A, STMN1, UCHL1
 35
HU_FETAL_RETINA_HORIZONTAL 1.70e-10 61.48 21.75 5.18e-09 1.14e-07
7NNAT, TUBB2B, STMN2, MLLT11, TUBA1A, STMN1, INA
 40
HU_FETAL_RETINA_RGC 1.58e-28 38.36 20.97 1.06e-25 1.06e-25
28NEFL, BASP1, NEFM, ELAVL2, TUBB2A, MAP1B, TUBB2B, VSTM2L, GAP43, STMN2, PCSK1N, FGF13, MLLT11, CRMP1, YWHAQ, TUBA1A, STMN1, ATAT1, CHN1, APLP1, MAPT, INA, NSG1, OLFM1, UCHL1, CALM2, STMN3, PAFAH1B3
 443
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 7.39e-27 37.32 20.38 1.65e-24 4.96e-24
26NEFL, BASP1, NEFM, ELAVL2, TUBB2A, MAP1B, TUBB2B, VSTM2L, GAP43, KIF21A, STMN2, FGF13, MLLT11, CRMP1, DOK6, TUBA1A, STMN1, APLP1, INA, NSG1, OLFM1, ZFHX3, UCHL1, MAP1LC3A, STMN3, PAFAH1B3
 389
TRAVAGLINI_LUNG_NEUROENDOCRINE_CELL 1.58e-15 38.15 18.12 7.55e-14 1.06e-12
13NNAT, MAP1B, TUBB2B, STMN2, PCSK1N, CRMP1, NRXN1, STMN1, PTMS, APLP1, VAMP2, INA, UCHL1
 128
DESCARTES_FETAL_STOMACH_ENS_NEURONS 1.02e-11 42.13 17.30 3.61e-10 6.87e-09
9TUBB2A, TUBB2B, GAP43, STMN2, MAPT, INA, KCNIP4, OLFM1, UCHL1
 74
MANNO_MIDBRAIN_NEUROTYPES_HNBML1 6.14e-21 29.49 15.80 1.03e-18 4.12e-18
21NNAT, BASP1, ELAVL2, MAP1B, TUBB2B, GAP43, KIF21A, STMN2, PCSK1N, MLLT11, CRMP1, DOK6, TUBA1A, STMN1, NREP, INA, NSG1, OLFM1, UCHL1, SYBU, PAFAH1B3
 328
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MATURE_NEURONS 2.59e-16 31.12 15.50 1.58e-14 1.74e-13
15NEFL, MAP1B, TUBB2B, GAP43, STMN2, PCSK1N, NRXN1, TUBA1A, APLP1, VAMP2, NSG1, OLFM1, UCHL1, CALM2, PAFAH1B3
 187
MANNO_MIDBRAIN_NEUROTYPES_HRN 2.64e-19 26.46 14.08 3.54e-17 1.77e-16
20NNAT, BASP1, ELAVL2, MAP1B, TUBB2B, GAP43, STMN2, MLLT11, CRMP1, NRXN1, DOK6, STMN1, NREP, APLP1, INA, NSG1, ZFHX3, UCHL1, SYBU, PAFAH1B3
 335
DESCARTES_FETAL_PANCREAS_ENS_NEURONS 3.68e-14 29.25 13.97 1.54e-12 2.47e-11
13NNAT, TUBB2A, MAP1B, TUBB2B, GAP43, STMN2, FGF13, MLLT11, TUBA1A, INA, KCNIP4, OLFM1, UCHL1
 163
DESCARTES_FETAL_INTESTINE_ENS_NEURONS 8.40e-13 26.65 12.42 3.13e-11 5.64e-10
12NEFM, TUBB2A, MAP1B, TUBB2B, GAP43, STMN2, FGF13, MLLT11, MAPT, INA, OLFM1, UCHL1
 160
MANNO_MIDBRAIN_NEUROTYPES_HSERT 3.56e-18 21.12 11.35 2.65e-16 2.39e-15
21BASP1, ELAVL2, TUBB2A, MAP1B, GAP43, STMN2, PCSK1N, FGF13, MLLT11, VSNL1, CRMP1, NRXN1, DOK6, APLP1, INA, NSG1, KCNIP4, ZFHX3, UCHL1, SYBU, MAP1LC3A
 450
MANNO_MIDBRAIN_NEUROTYPES_HDA 1.82e-18 20.31 10.98 1.77e-16 1.22e-15
22NNAT, BASP1, ELAVL2, MAP1B, TUBB2B, GAP43, STMN2, FGF13, MLLT11, CRMP1, MAB21L1, NRXN1, DOK6, TUBA1A, STMN1, NREP, APLP1, INA, NSG1, KCNIP4, ZFHX3, UCHL1
 506
MANNO_MIDBRAIN_NEUROTYPES_HDA2 2.41e-18 20.02 10.83 2.02e-16 1.62e-15
22NNAT, BASP1, ELAVL2, TUBB2A, MAP1B, TUBB2B, GAP43, STMN2, FGF13, MLLT11, VSNL1, CRMP1, DOK6, TUBA1A, STMN1, NREP, APLP1, INA, NSG1, KCNIP4, ZFHX3, UCHL1
 513
DESCARTES_FETAL_ADRENAL_CHROMAFFIN_CELLS 7.61e-10 24.92 10.39 2.13e-08 5.10e-07
9BASP1, ELAVL2, TUBB2A, CCND1, MAP1B, TUBB2B, GAP43, MLLT11, MAB21L1
 119
MANNO_MIDBRAIN_NEUROTYPES_HDA1 1.84e-18 19.00 10.33 1.77e-16 1.24e-15
23NNAT, BASP1, ELAVL2, MAP1B, TUBB2B, GAP43, KIF21A, STMN2, PCSK1N, FGF13, MLLT11, VSNL1, CRMP1, MAB21L1, NRXN1, DOK6, NREP, APLP1, INA, NSG1, KCNIP4, ZFHX3, UCHL1
 584
ZHONG_PFC_C3_MICROGLIA 3.31e-16 17.82 9.52 1.85e-14 2.22e-13
20NEFL, NEFM, TUBB2A, MAP1B, TUBB2B, VSTM2L, GAP43, STMN2, MARCKSL1, PCSK1N, FGF13, CRMP1, NRXN1, TUBA1A, MAPT, INA, NSG1, UCHL1, SYBU, STMN3
 488
MANNO_MIDBRAIN_NEUROTYPES_HNBML5 4.09e-14 15.74 8.25 1.61e-12 2.74e-11
18NNAT, BASP1, ELAVL2, MAP1B, TUBB2B, KIF21A, STMN2, MLLT11, VSNL1, CRMP1, NRXN1, DOK6, NREP, APLP1, INA, NSG1, ZFHX3, SYBU
 465

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.08e-03 7.12 2.18 5.40e-02 5.40e-02
5CCND1, TUBB2B, MAPT, OLFM1, SYBU
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 4.35e-02 4.05 0.80 1.00e+00 1.00e+00
3CCND1, MAPT, OLFM1
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2TUBB2A, CCND1
 200
HALLMARK_G2M_CHECKPOINT 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2CCND1, STMN1
 200
HALLMARK_MYC_TARGETS_V1 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2YWHAQ, YWHAE
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2BASP1, APLP1
 200
HALLMARK_KRAS_SIGNALING_UP 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2PCSK1N, TRIB2
 200
HALLMARK_NOTCH_SIGNALING 1.20e-01 8.23 0.20 1.00e+00 1.00e+00
1CCND1
 32
HALLMARK_HEDGEHOG_SIGNALING 1.34e-01 7.29 0.18 1.00e+00 1.00e+00
1CRMP1
 36
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 1.00e+00 1.00e+00
1CCND1
 100
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 3.62e-01 2.28 0.06 1.00e+00 1.00e+00
1TUBB2A
 113
HALLMARK_SPERMATOGENESIS 4.15e-01 1.90 0.05 1.00e+00 1.00e+00
1PCSK1N
 135
HALLMARK_UV_RESPONSE_DN 4.35e-01 1.78 0.04 1.00e+00 1.00e+00
1MAP1B
 144
HALLMARK_UV_RESPONSE_UP 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1OLFM1
 158
HALLMARK_APOPTOSIS 4.72e-01 1.59 0.04 1.00e+00 1.00e+00
1CCND1
 161
HALLMARK_MITOTIC_SPINDLE 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1YWHAE
 199
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1APLP1
 199
HALLMARK_MTORC1_SIGNALING 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1MLLT11
 200
HALLMARK_E2F_TARGETS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1STMN1
 200
HALLMARK_GLYCOLYSIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1STMN1
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 6.91e-05 20.88 5.27 1.29e-02 1.29e-02
4TUBB2A, TUBB2B, YWHAQ, TUBA1A
 56
KEGG_GAP_JUNCTION 5.37e-03 9.17 1.79 4.98e-01 1.00e+00
3TUBB2A, TUBB2B, TUBA1A
 90
KEGG_OOCYTE_MEIOSIS 1.00e-02 7.25 1.42 4.98e-01 1.00e+00
3YWHAQ, YWHAE, CALM2
 113
KEGG_CELL_CYCLE 1.31e-02 6.54 1.28 4.98e-01 1.00e+00
3CCND1, YWHAQ, YWHAE
 125
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 1.34e-02 6.49 1.27 4.98e-01 1.00e+00
3YWHAQ, YWHAE, CALM2
 126
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 1.87e-02 10.20 1.17 4.98e-01 1.00e+00
2NEFL, NEFM
 53
KEGG_MAPK_SIGNALING_PATHWAY 2.00e-02 4.13 1.07 4.98e-01 1.00e+00
4FGF13, STMN1, MAPT, RAC3
 267
KEGG_COLORECTAL_CANCER 2.50e-02 8.68 1.00 4.98e-01 1.00e+00
2CCND1, RAC3
 62
KEGG_GLIOMA 2.73e-02 8.26 0.95 4.98e-01 1.00e+00
2CCND1, CALM2
 65
KEGG_PANCREATIC_CANCER 3.13e-02 7.66 0.88 4.98e-01 1.00e+00
2CCND1, RAC3
 70
KEGG_VIRAL_MYOCARDITIS 3.13e-02 7.66 0.88 4.98e-01 1.00e+00
2CCND1, RAC3
 70
KEGG_MELANOMA 3.21e-02 7.55 0.87 4.98e-01 1.00e+00
2CCND1, FGF13
 71
KEGG_PATHWAYS_IN_CANCER 1.32e-01 2.48 0.49 1.00e+00 1.00e+00
3CCND1, FGF13, RAC3
 325
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES 5.81e-02 18.20 0.42 8.31e-01 1.00e+00
1ST6GALNAC5
 15
KEGG_WNT_SIGNALING_PATHWAY 1.19e-01 3.50 0.41 1.00e+00 1.00e+00
2CCND1, RAC3
 151
KEGG_ALZHEIMERS_DISEASE 1.39e-01 3.18 0.37 1.00e+00 1.00e+00
2MAPT, CALM2
 166
KEGG_FOCAL_ADHESION 1.83e-01 2.64 0.31 1.00e+00 1.00e+00
2CCND1, RAC3
 199
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 2.03e-01 2.47 0.29 1.00e+00 1.00e+00
2FGF13, RAC3
 213
KEGG_THYROID_CANCER 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1CCND1
 29
KEGG_ETHER_LIPID_METABOLISM 1.23e-01 7.97 0.19 1.00e+00 1.00e+00
1PAFAH1B3
 33

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2p24 3.47e-02 7.23 0.84 1.00e+00 1.00e+00
2VSNL1, TRIB2
 74
chr6p25 4.17e-02 6.51 0.75 1.00e+00 1.00e+00
2TUBB2A, TUBB2B
 82
chr20q11 6.53e-02 3.41 0.67 1.00e+00 1.00e+00
3NNAT, VSTM2L, MAP1LC3A
 237
chr8p21 9.06e-02 4.13 0.48 1.00e+00 1.00e+00
2NEFL, NEFM
 128
chr4p16 2.00e-01 2.49 0.29 1.00e+00 1.00e+00
2CRMP1, NSG1
 211
chr4p13 1.16e-01 8.50 0.20 1.00e+00 1.00e+00
1UCHL1
 31
chr17p13 3.76e-01 1.56 0.18 1.00e+00 1.00e+00
2VAMP2, YWHAE
 336
chr8q23 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1SYBU
 44
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1PSD3
 45
chr7q33 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1PTN
 52
chr5q22 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1NREP
 55
chr12q12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1KIF21A
 58
chr18q22 2.16e-01 4.25 0.10 1.00e+00 1.00e+00
1DOK6
 61
chr13q13 2.67e-01 3.31 0.08 1.00e+00 1.00e+00
1MAB21L1
 78
chr2p21 2.73e-01 3.23 0.08 1.00e+00 1.00e+00
1CALM2
 80
chr7p21 2.81e-01 3.11 0.08 1.00e+00 1.00e+00
1NXPH1
 83
chrXq27 2.98e-01 2.90 0.07 1.00e+00 1.00e+00
1FGF13
 89
chr2p16 3.64e-01 2.26 0.06 1.00e+00 1.00e+00
1NRXN1
 114
chr2p25 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1YWHAQ
 117
chr19q13 4.39e-01 0.45 0.05 1.00e+00 1.00e+00
2APLP1, PAFAH1B3
 1165

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
YGCANTGCR_UNKNOWN 5.99e-07 16.95 6.30 6.57e-04 6.79e-04
7NNAT, MAP1B, FGF13, MLLT11, VSNL1, NRXN1, CALM2
 127
CATTGTYY_SOX9_B1 1.16e-06 8.73 3.86 6.57e-04 1.31e-03
10BASP1, MAP1B, TUBB2B, CRMP1, YWHAQ, TUBA1A, STMN1, CHN1, OLFM1, TRIB2
 368
PAX4_03 5.94e-06 9.60 3.85 1.91e-03 6.73e-03
8MAP1B, STMN2, PCSK1N, MAB21L1, STMN1, PTMS, NREP, YWHAE
 256
CDP_01 5.29e-04 11.94 3.06 4.96e-02 5.99e-01
4CCND1, STMN2, FGF13, ST6GALNAC5
 95
SRY_02 6.06e-05 8.08 3.03 1.14e-02 6.87e-02
7ELAVL2, MAP1B, PTN, MAB21L1, CHN1, NREP, OLFM1
 259
YGACNNYACAR_UNKNOWN 6.17e-04 11.44 2.93 4.99e-02 6.99e-01
4MARCKSL1, FGF13, NRXN1, PSD3
 99
GGGYGTGNY_UNKNOWN 6.73e-06 5.86 2.77 1.91e-03 7.62e-03
12MAP1B, GAP43, MLLT11, CRMP1, TUBA1A, STMN1, ATAT1, VAMP2, UCHL1, TRIB2, CALM2, PAFAH1B3
 686
SOX9_B1 3.13e-04 7.35 2.53 3.54e-02 3.54e-01
6BASP1, ELAVL2, MARCKSL1, MLLT11, OLFM1, TRIB2
 238
RYTGCNWTGGNR_UNKNOWN 1.18e-03 9.53 2.45 6.71e-02 1.00e+00
4NNAT, PCSK1N, YWHAQ, KCNIP4
 118
CTGCAGY_UNKNOWN 2.26e-05 5.15 2.44 5.12e-03 2.56e-02
12NEFL, NNAT, MAP1B, STMN2, PCSK1N, FGF13, VSNL1, NRXN1, TUBA1A, MAPT, YWHAE, KCNIP4
 779
AP2REP_01 7.11e-04 7.85 2.40 5.37e-02 8.06e-01
5NEFL, TUBB2B, MARCKSL1, MAPT, NXPH1
 182
GGCKCATGS_UNKNOWN 2.45e-03 12.27 2.38 1.09e-01 1.00e+00
3BASP1, CCND1, VSNL1
 68
YYCATTCAWW_UNKNOWN 9.02e-04 7.43 2.27 6.00e-02 1.00e+00
5BASP1, CCND1, GAP43, TUBA1A, TRIB2
 192
ERR1_Q2 5.69e-04 6.53 2.25 4.96e-02 6.45e-01
6NEFM, MAP1B, VSTM2L, VSNL1, VAMP2, UCHL1
 267
LEF1_Q6 5.69e-04 6.53 2.25 4.96e-02 6.45e-01
6BASP1, ELAVL2, GAP43, MARCKSL1, TUBA1A, ZFHX3
 267
TGACCTY_ERR1_Q2 8.73e-05 4.18 2.03 1.41e-02 9.90e-02
13NNAT, NEFM, MAP1B, MARCKSL1, VSNL1, NRXN1, STMN1, ATAT1, NREP, VAMP2, UCHL1, PSD3, CALM2
 1064
GTGGGTGK_UNKNOWN 9.81e-04 5.86 2.02 6.00e-02 1.00e+00
6BASP1, ELAVL2, TUBB2B, MARCKSL1, MAPT, UCHL1
 297
SMTTTTGT_UNKNOWN 8.92e-04 5.09 1.92 6.00e-02 1.00e+00
7MAP1B, TUBB2B, NRXN1, YWHAQ, STMN1, CHN1, YWHAE
 407
YTAAYNGCT_UNKNOWN 3.10e-03 7.25 1.87 1.10e-01 1.00e+00
4NRXN1, INA, KCNIP4, ZFHX3
 154
GGGTGGRR_PAX4_03 1.53e-04 3.75 1.87 2.00e-02 1.73e-01
14ELAVL2, MAP1B, GAP43, STMN2, MARCKSL1, PCSK1N, YWHAQ, PTMS, NREP, MAPT, YWHAE, NXPH1, TRIB2, MAP1LC3A
 1310

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_AXONAL_TRANSPORT_OF_MITOCHONDRION 2.09e-05 72.24 12.54 5.58e-03 1.57e-01
3NEFL, MAPT, SYBU
 14
GOBP_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION 2.63e-06 51.58 12.40 1.04e-03 1.97e-02
4NEFL, MAP1B, MAPT, SYBU
 25
GOBP_SUBSTANTIA_NIGRA_DEVELOPMENT 6.91e-07 36.47 10.72 4.15e-04 5.17e-03
5BASP1, YWHAQ, INA, YWHAE, CALM2
 43
GOBP_MICROTUBULE_DEPOLYMERIZATION 7.77e-07 35.54 10.46 4.15e-04 5.81e-03
5MAP1B, STMN2, FGF13, STMN1, STMN3
 44
GOBP_INTERMEDIATE_FILAMENT_BUNDLE_ASSEMBLY 3.22e-04 103.49 9.64 5.48e-02 1.00e+00
2NEFL, NEFM
 7
GOBP_NEUROFILAMENT_CYTOSKELETON_ORGANIZATION 4.28e-04 86.37 8.33 6.97e-02 1.00e+00
2NEFL, INA
 8
GOBP_NEGATIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION 1.32e-05 32.88 8.14 3.80e-03 9.89e-02
4MAP1B, STMN2, FGF13, STMN1
 37
GOBP_NEURON_PROJECTION_REGENERATION 3.13e-06 26.18 7.80 1.11e-03 2.34e-02
5NEFL, MAP1B, GAP43, PTN, NREP
 58
GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION 7.32e-07 22.70 7.67 4.15e-04 5.47e-03
6MAP1B, STMN2, FGF13, STMN1, MAPT, STMN3
 81
GOBP_NEURAL_NUCLEUS_DEVELOPMENT 3.70e-06 25.20 7.53 1.26e-03 2.77e-02
5BASP1, YWHAQ, INA, YWHAE, CALM2
 60
GOBP_PERIPHERAL_NERVOUS_SYSTEM_AXON_REGENERATION 5.49e-04 74.10 7.33 8.56e-02 1.00e+00
2NEFL, MAP1B
 9
GOBP_SYNAPSE_MATURATION 1.13e-04 37.87 7.01 2.35e-02 8.45e-01
3NEFL, NRXN1, SYBU
 24
GOBP_MITOCHONDRION_LOCALIZATION 3.46e-05 25.26 6.32 8.34e-03 2.58e-01
4NEFL, MAP1B, MAPT, SYBU
 47
GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION 4.42e-05 23.58 5.93 1.03e-02 3.31e-01
4MAP1B, STMN2, STMN1, MAPT
 50
GOBP_REGULATION_OF_MICROTUBULE_CYTOSKELETON_ORGANIZATION 9.96e-07 15.65 5.83 4.97e-04 7.45e-03
7MAP1B, STMN2, FGF13, STMN1, ATAT1, MAPT, STMN3
 137
GOBP_MICROTUBULE_POLYMERIZATION 1.26e-05 19.27 5.80 3.78e-03 9.46e-02
5MAP1B, STMN2, FGF13, STMN1, MAPT
 77
GOBP_RESPONSE_TO_AXON_INJURY 1.26e-05 19.27 5.80 3.78e-03 9.46e-02
5NEFL, MAP1B, GAP43, PTN, NREP
 77
GOBP_REGULATION_OF_MICROTUBULE_DEPOLYMERIZATION 2.01e-04 30.63 5.74 4.06e-02 1.00e+00
3MAP1B, STMN2, FGF13
 29
GOBP_AXON_DEVELOPMENT 3.60e-10 10.89 5.49 2.69e-06 2.69e-06
15NEFL, MAP1B, TUBB2B, VSTM2L, GAP43, PTN, FGF13, CRMP1, NRXN1, DOK6, STMN1, CHN1, NREP, MAPT, OLFM1
 507
GOBP_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION 5.37e-06 15.77 5.38 1.75e-03 4.02e-02
6MAP1B, STMN2, FGF13, STMN1, MAPT, STMN3
 114

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE24574_BCL6_HIGH_VS_LOW_TFH_CD4_TCELL_UP 1.06e-03 7.16 2.19 9.88e-01 1.00e+00
5TUBB2A, STMN2, TUBA1A, VAMP2, TRIB2
 199
GSE30083_SP1_VS_SP4_THYMOCYTE_UP 1.08e-03 7.12 2.18 9.88e-01 1.00e+00
5TUBB2B, MARCKSL1, TUBA1A, UCHL1, PSD3
 200
GSE37605_TREG_VS_TCONV_C57BL6_FOXP3_FUSION_GFP_UP 1.93e-03 8.30 2.14 9.88e-01 1.00e+00
4BASP1, PTN, FGF13, CRMP1
 135
GSE5589_WT_VS_IL10_KO_LPS_STIM_MACROPHAGE_180MIN_DN 3.17e-03 7.20 1.86 9.88e-01 1.00e+00
4STMN1, OLFM1, PSD3, PAFAH1B3
 155
GSE29618_BCELL_VS_PDC_DAY7_FLU_VACCINE_UP 6.83e-03 5.75 1.49 9.88e-01 1.00e+00
4BASP1, TUBB2A, TUBA1A, TRIB2
 193
GSE19401_PLN_VS_PEYERS_PATCH_FOLLICULAR_DC_UP 7.20e-03 5.66 1.47 9.88e-01 1.00e+00
4NEFL, FGF13, TRIB2, PAFAH1B3
 196
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_DP_THYMOCYTES_UP 7.45e-03 5.60 1.45 9.88e-01 1.00e+00
4TUBB2A, MLLT11, NREP, UCHL1
 198
GSE1460_CD4_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_UP 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4MARCKSL1, MLLT11, YWHAQ, STMN1
 199
GSE17721_CTRL_VS_CPG_24H_BMDC_DN 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4PTN, MARCKSL1, YWHAE, STMN3
 199
GSE360_CTRL_VS_L_MAJOR_MAC_UP 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4TUBB2A, NREP, APLP1, RAC3
 199
GSE5455_HEALTHY_VS_TUMOR_BEARING_MOUSE_SPLEEN_MONOCYTE_24H_INCUBATION_UP 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4TUBB2A, TUBB2B, MLLT11, PSD3
 199
GSE6674_CPG_VS_CPG_AND_ANTI_IGM_STIM_BCELL_UP 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4TUBB2A, TUBB2B, MARCKSL1, TUBA1A
 199
GSE15735_2H_VS_12H_HDAC_INHIBITOR_TREATED_CD4_TCELL_UP 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4TUBB2B, CRMP1, STMN1, TRIB2
 199
GSE25085_FETAL_BM_VS_ADULT_BM_SP4_THYMIC_IMPLANT_DN 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4BASP1, CCND1, MARCKSL1, PTMS
 199
GSE28726_NAIVE_CD4_TCELL_VS_NAIVE_NKTCELL_UP 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4TUBB2A, TUBA1A, YWHAE, CALM2
 199
GSE22025_UNTREATED_VS_PROGESTERONE_TREATED_CD4_TCELL_DN 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4BASP1, STMN2, YWHAQ, CALM2
 199
GSE35543_IN_VIVO_NTREG_VS_CONVERTED_EX_ITREG_DN 7.58e-03 5.57 1.44 9.88e-01 1.00e+00
4PTN, PCSK1N, NSG1, STMN3
 199
GSE1460_CD4_THYMOCYTE_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP 7.71e-03 5.55 1.44 9.88e-01 1.00e+00
4MLLT11, YWHAQ, STMN1, NREP
 200
GSE17721_CPG_VS_GARDIQUIMOD_0.5H_BMDC_DN 7.71e-03 5.55 1.44 9.88e-01 1.00e+00
4BASP1, YWHAE, PSD3, MAP1LC3A
 200
GSE19825_NAIVE_VS_DAY3_EFF_CD8_TCELL_UP 7.71e-03 5.55 1.44 9.88e-01 1.00e+00
4ELAVL2, VSTM2L, NREP, NXPH1
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MLLT11 18 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZFHX3 41 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
SHOX2 52 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HOXC9 56 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HAND2 58 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
SOX11 71 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
MEIS3 80 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RUNX1T1 86 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
GATA3 90 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
SSBP2 103 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in DNA damage response. Has domain IPR008116 Sequence-specific single-strand DNA-binding protein
MEIS1 106 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
SMARCD3 120 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Chromatin remodelling complex component
CSRNP3 153 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538)
HOXC8 166 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HSBP1 169 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that has been shown to bind to HSF1 leading to inhibition of its trimerization and DNA-binding( PMID: 9649501).
SOX4 174 Yes Known motif Monomer or homomultimer High-throughput in vitro None Also binds ssDNA loops.
ISL1 181 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MAPK10 184 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase
HDAC2 185 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Histone deacetylase; likely to be a transcriptional cofactor
THRA 187 Yes Known motif Monomer or homomultimer High-throughput in vitro None Likely binds as a heterodimer too


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
STDY8004902_GTACGTAAGAGTACAT Neurons:adrenal_medulla_cell_line 0.23 636.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.39, Neurons:ES_cell-derived_neural_precursor: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, Embryonic_stem_cells: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.34
STDY8004902_GTGGGTCGTCGGGTCT Neurons:adrenal_medulla_cell_line 0.21 515.80
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, Embryonic_stem_cells: 0.36, iPS_cells:PDB_2lox-22: 0.36
STDY8004902_CTGTTTATCACCACCT Neurons:adrenal_medulla_cell_line 0.22 379.06
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.32
STDY8004902_GGAATAATCGTAGATC Neurons:adrenal_medulla_cell_line 0.22 340.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.36, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Embryonic_stem_cells: 0.32, iPS_cells:PDB_2lox-5: 0.32
STDY8004902_AACGTTGTCTCCCTGA Neurons:adrenal_medulla_cell_line 0.23 336.52
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.32
STDY8004902_TATCTCAGTACAAGTA Neurons:adrenal_medulla_cell_line 0.25 294.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.51, Neuroepithelial_cell:ESC-derived: 0.46, Astrocyte:Embryonic_stem_cell-derived: 0.44, Neurons:ES_cell-derived_neural_precursor: 0.42, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_1lox-17Puro-10: 0.41, Embryonic_stem_cells: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.41, iPS_cells:PDB_2lox-22: 0.4
STDY8004910_GTCAAGTGTACTTAGC Neurons:adrenal_medulla_cell_line 0.22 281.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, Embryonic_stem_cells: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.33
STDY8004910_ACGTCAAGTGTATGGG Neurons:adrenal_medulla_cell_line 0.22 277.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, Embryonic_stem_cells: 0.3
STDY8004902_CAGAGAGTCGTCTGCT Neurons:adrenal_medulla_cell_line 0.22 275.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_2lox-5: 0.31
STDY8004902_TGACTAGCAAAGTGCG Neurons:adrenal_medulla_cell_line 0.21 269.96
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-22: 0.29
STDY8004902_GTCACGGCAGATGGGT Neurons:adrenal_medulla_cell_line 0.21 269.10
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_2lox-22: 0.31
STDY8004902_CTCTGGTCAAGCCATT Neurons:adrenal_medulla_cell_line 0.22 251.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33
STDY8004894_GTTCGGGAGATACACA Neurons:adrenal_medulla_cell_line 0.14 251.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, Neurons:Schwann_cell: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, Embryonic_stem_cells: 0.27
STDY8004902_CTGATCCTCTTGCAAG Neurons:adrenal_medulla_cell_line 0.22 250.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-5: 0.29
STDY8004910_TTTACTGTCATCGCTC Neurons:adrenal_medulla_cell_line 0.18 247.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, Embryonic_stem_cells: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-5: 0.31
STDY8004902_GGAACTTGTACACCGC Neurons:adrenal_medulla_cell_line 0.20 240.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, Embryonic_stem_cells: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_2lox-22: 0.29
STDY8004902_GACTACACAGTATGCT Neurons:adrenal_medulla_cell_line 0.21 237.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, Embryonic_stem_cells: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_2lox-22: 0.25
STDY8004902_GTAGTCAGTAAGGGCT Neurons:adrenal_medulla_cell_line 0.20 224.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-22: 0.3
STDY8004910_GAAATGATCGTATCAG Neurons:adrenal_medulla_cell_line 0.19 223.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-21: 0.3
STDY8004910_CCTTCGATCGCGCCAA Neurons:adrenal_medulla_cell_line 0.20 220.96
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31, Embryonic_stem_cells: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-22: 0.3
STDY8004902_TTGAACGTCTACTTAC Neurons:adrenal_medulla_cell_line 0.21 216.07
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.3
STDY8004902_GATCGCGTCAGTCAGT Neurons:adrenal_medulla_cell_line 0.21 211.75
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-5: 0.32
STDY8004902_GCGACCAGTCCTAGCG Neurons:adrenal_medulla_cell_line 0.24 210.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.51, Neuroepithelial_cell:ESC-derived: 0.46, Astrocyte:Embryonic_stem_cell-derived: 0.43, iPS_cells:PDB_1lox-21Puro-20: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.42, iPS_cells:PDB_2lox-22: 0.42, iPS_cells:PDB_1lox-21Puro-26: 0.42, Embryonic_stem_cells: 0.42, iPS_cells:PDB_1lox-17Puro-5: 0.41
STDY8004910_TAGAGCTTCAAGATCC Neurons:adrenal_medulla_cell_line 0.21 207.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, Embryonic_stem_cells: 0.33
STDY8004910_GTCACAATCATAGCAC Neurons:adrenal_medulla_cell_line 0.21 207.09
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, Embryonic_stem_cells: 0.26, iPS_cells:PDB_2lox-5: 0.26
STDY8004910_CGCGTTTGTCTACCTC Neurons:adrenal_medulla_cell_line 0.22 205.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.43, Astrocyte:Embryonic_stem_cell-derived: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.38, Embryonic_stem_cells: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38
STDY8004910_GTACTTTTCCACGTGG Neurons:adrenal_medulla_cell_line 0.22 205.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.34, Embryonic_stem_cells: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33
STDY8004910_GCTGCAGTCTACTCAT Neurons:adrenal_medulla_cell_line 0.20 205.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_2lox-22: 0.31
STDY8004894_AGAATAGTCTCGTTTA Neurons:adrenal_medulla_cell_line 0.12 204.62
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:Schwann_cell: 0.31, iPS_cells:iPS:minicircle-derived: 0.3, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.3, Embryonic_stem_cells: 0.3, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29
STDY8004902_CTCGGAGGTCCCGACA Neurons:adrenal_medulla_cell_line 0.24 203.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, Embryonic_stem_cells: 0.38
STDY8004910_ATCCACCAGAGACTAT Neurons:adrenal_medulla_cell_line 0.20 203.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_2lox-22: 0.28
STDY8004902_AGATCTGCATGAAGTA Neurons:adrenal_medulla_cell_line 0.24 199.48
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.49, Neuroepithelial_cell:ESC-derived: 0.43, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.4, iPS_cells:PDB_1lox-21Puro-26: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.39, iPS_cells:PDB_1lox-17Puro-5: 0.39, Neurons:ES_cell-derived_neural_precursor: 0.39, iPS_cells:PDB_2lox-22: 0.39, Embryonic_stem_cells: 0.38
STDY8004894_CAAGTTGTCCCGGATG Neurons:adrenal_medulla_cell_line 0.14 198.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neuroepithelial_cell:ESC-derived: 0.32, iPS_cells:iPS:minicircle-derived: 0.28, Neurons:Schwann_cell: 0.28, iPS_cells:PDB_2lox-5: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:skin_fibroblast-derived: 0.28, Embryonic_stem_cells: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28
STDY8004902_CACATAGCAGCTGCTG Neurons:adrenal_medulla_cell_line 0.20 190.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.32, Embryonic_stem_cells: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-5: 0.31
STDY8004902_GACTAACAGAGACTTA Neurons:adrenal_medulla_cell_line 0.23 189.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.32, Embryonic_stem_cells: 0.32
STDY8004902_GACACGCTCTTACCGC Neurons:adrenal_medulla_cell_line 0.23 188.71
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.48, Neuroepithelial_cell:ESC-derived: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.4, iPS_cells:PDB_1lox-21Puro-26: 0.4, iPS_cells:PDB_1lox-17Puro-10: 0.4, iPS_cells:PDB_2lox-22: 0.4, iPS_cells:PDB_1lox-17Puro-5: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.4, iPS_cells:PDB_2lox-17: 0.39
STDY8004910_TTCGAAGCAGCATACT Neurons:adrenal_medulla_cell_line 0.21 187.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_2lox-22: 0.31
STDY8004910_TGGCCAGGTTTAAGCC Neurons:adrenal_medulla_cell_line 0.18 184.86
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_2lox-22: 0.28, Embryonic_stem_cells: 0.27
STDY8004910_CTCAGAACACTTAAGC Neurons:adrenal_medulla_cell_line 0.20 184.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_2lox-5: 0.28
STDY8004910_GACCTGGAGAGCTGGT Neurons:adrenal_medulla_cell_line 0.20 183.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29
STDY8004902_GACACGCAGTGTACGG Neurons:adrenal_medulla_cell_line 0.19 177.80
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, Embryonic_stem_cells: 0.29
STDY8004910_AAACGGGGTAGCCTCG Neurons:adrenal_medulla_cell_line 0.18 177.62
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:iPS:minicircle-derived: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28
STDY8004902_GCTTGAAAGCAGATCG Neurons:adrenal_medulla_cell_line 0.21 177.30
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.35, Embryonic_stem_cells: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-22: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35
STDY8004910_GACAGAGGTAGGCATG Neurons:adrenal_medulla_cell_line 0.21 176.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_2lox-22: 0.34, Embryonic_stem_cells: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34
STDY8004910_CTCCTAGTCCGAACGC Neurons:adrenal_medulla_cell_line 0.19 176.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28
STDY8004910_CACCAGGCAAAGTGCG Neurons:adrenal_medulla_cell_line 0.20 175.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.4, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.36, Embryonic_stem_cells: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:iPS:minicircle-derived: 0.36
STDY8004902_TGGGCGTTCAACACTG Neurons:adrenal_medulla_cell_line 0.25 175.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.52, Neuroepithelial_cell:ESC-derived: 0.46, Astrocyte:Embryonic_stem_cell-derived: 0.43, iPS_cells:PDB_1lox-21Puro-20: 0.43, iPS_cells:PDB_2lox-22: 0.42, iPS_cells:PDB_1lox-21Puro-26: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.42, iPS_cells:PDB_1lox-17Puro-5: 0.42, iPS_cells:PDB_2lox-17: 0.42, iPS_cells:PDB_2lox-21: 0.42
STDY8004902_AAGGTTCTCGGTCCGA Neurons:adrenal_medulla_cell_line 0.23 175.06
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-21: 0.31, Embryonic_stem_cells: 0.31
STDY8004910_GGAAAGCTCAGCTCGG Neurons:adrenal_medulla_cell_line 0.20 174.99
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, Embryonic_stem_cells: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.28
STDY8004910_GGACAGACATCGATTG Neurons:adrenal_medulla_cell_line 0.20 173.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, Embryonic_stem_cells: 0.29, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.29


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.36e-09
Mean rank of genes in gene set: 90
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NEFL 0.0176205 1 GTEx DepMap Descartes 10.26 847.86
BASP1 0.0157331 3 GTEx DepMap Descartes 22.17 3551.72
NEFM 0.0156529 4 GTEx DepMap Descartes 5.15 502.73
CCND1 0.0132328 7 GTEx DepMap Descartes 11.78 931.46
STMN2 0.0115029 14 GTEx DepMap Descartes 79.25 11503.56
STMN1 0.0094616 26 GTEx DepMap Descartes 44.37 4278.99
INA 0.0087028 35 GTEx DepMap Descartes 2.07 179.62
ELAVL3 0.0066746 115 GTEx DepMap Descartes 2.68 147.96
ELAVL4 0.0060127 151 GTEx DepMap Descartes 10.39 710.05
ISL1 0.0056092 181 GTEx DepMap Descartes 2.47 287.06
RTN1 0.0036880 453 GTEx DepMap Descartes 31.55 2838.48


N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.83e-06
Mean rank of genes in gene set: 2084.44
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CELF4 0.0078683 59 GTEx DepMap Descartes 4.41 314.24
PCLO 0.0078270 62 GTEx DepMap Descartes 2.15 32.55
SNAP25 0.0072552 81 GTEx DepMap Descartes 4.30 532.70
CACNA2D1 0.0048243 250 GTEx DepMap Descartes 0.95 39.46
SCG3 0.0048043 255 GTEx DepMap Descartes 2.87 251.43
SCG5 0.0047899 259 GTEx DepMap Descartes 2.92 664.90
PTPRN 0.0043966 320 GTEx DepMap Descartes 1.20 59.77
NAP1L5 0.0041877 359 GTEx DepMap Descartes 1.02 156.31
PPFIA2 0.0032549 607 GTEx DepMap Descartes 0.25 13.62
ADCYAP1R1 0.0024753 993 GTEx DepMap Descartes 0.14 4.42
GNAS 0.0023555 1070 GTEx DepMap Descartes 21.39 1377.51
SYN2 0.0013813 2023 GTEx DepMap Descartes 0.08 5.51
C1QL1 0.0008729 2963 GTEx DepMap Descartes 1.08 168.26
SLCO3A1 0.0001369 5620 GTEx DepMap Descartes 1.33 66.06
CXCL14 -0.0003388 8982 GTEx DepMap Descartes 0.08 12.46
LGR5 -0.0004092 9448 GTEx DepMap Descartes 0.00 0.00


Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.57e-06
Mean rank of genes in gene set: 2148.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NNAT 0.0176045 2 GTEx DepMap Descartes 21.81 5568.78
MAP1B 0.0120524 8 GTEx DepMap Descartes 30.10 678.27
PCSK1N 0.0106874 16 GTEx DepMap Descartes 15.61 4456.82
UCHL1 0.0084638 42 GTEx DepMap Descartes 12.87 2221.59
HAND2 0.0078807 58 GTEx DepMap Descartes 5.23 547.52
GATA3 0.0071155 90 GTEx DepMap Descartes 4.97 495.88
CHGB 0.0068868 101 GTEx DepMap Descartes 13.05 1536.58
DBH 0.0033463 576 GTEx DepMap Descartes 4.90 485.24
DISP2 0.0020073 1293 GTEx DepMap Descartes 0.46 10.58
SLC18A1 0.0016991 1614 GTEx DepMap Descartes 0.93 83.21
TH 0.0014158 1973 GTEx DepMap Descartes 3.42 496.65
PHOX2A 0.0009444 2812 GTEx DepMap Descartes 3.98 554.60
CHGA 0.0005540 3898 GTEx DepMap Descartes 2.68 322.72
EML5 0.0000002 6340 GTEx DepMap Descartes 0.35 9.35
DDC -0.0000070 6405 GTEx DepMap Descartes 1.80 221.01
CYB561 -0.0003649 9148 GTEx DepMap Descartes 0.63 42.78




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.29e-54
Mean rank of genes in gene set: 3117.99
Median rank of genes in gene set: 1345
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NEFL 0.0176205 1 GTEx DepMap Descartes 10.26 847.86
NNAT 0.0176045 2 GTEx DepMap Descartes 21.81 5568.78
NEFM 0.0156529 4 GTEx DepMap Descartes 5.15 502.73
ELAVL2 0.0137525 5 GTEx DepMap Descartes 4.90 379.38
TUBB2A 0.0136470 6 GTEx DepMap Descartes 23.94 4130.33
CCND1 0.0132328 7 GTEx DepMap Descartes 11.78 931.46
MAP1B 0.0120524 8 GTEx DepMap Descartes 30.10 678.27
TUBB2B 0.0120385 9 GTEx DepMap Descartes 33.41 4911.03
GAP43 0.0116845 11 GTEx DepMap Descartes 19.14 2862.35
KIF21A 0.0115873 13 GTEx DepMap Descartes 4.45 193.39
STMN2 0.0115029 14 GTEx DepMap Descartes 79.25 11503.56
CRMP1 0.0103358 20 GTEx DepMap Descartes 4.52 411.14
MAPT 0.0087486 34 GTEx DepMap Descartes 5.19 207.95
INA 0.0087028 35 GTEx DepMap Descartes 2.07 179.62
NSG1 0.0086282 36 GTEx DepMap Descartes 3.74 NA
OLFM1 0.0085241 39 GTEx DepMap Descartes 3.12 339.47
GDI1 0.0079156 55 GTEx DepMap Descartes 4.19 308.01
MAP2 0.0078384 61 GTEx DepMap Descartes 3.99 112.49
DPYSL2 0.0076020 67 GTEx DepMap Descartes 5.40 305.66
ENO2 0.0075819 68 GTEx DepMap Descartes 3.59 330.11
SOX11 0.0075381 71 GTEx DepMap Descartes 4.54 146.26
ACOT7 0.0074559 74 GTEx DepMap Descartes 3.71 403.97
PRSS12 0.0074423 75 GTEx DepMap Descartes 0.41 29.43
KIF5C 0.0073162 78 GTEx DepMap Descartes 4.33 165.76
SNAP25 0.0072552 81 GTEx DepMap Descartes 4.30 532.70
DCX 0.0072389 82 GTEx DepMap Descartes 2.40 74.10
CKB 0.0071993 85 GTEx DepMap Descartes 5.29 1033.63
DPYSL3 0.0071510 88 GTEx DepMap Descartes 3.13 162.15
GATA3 0.0071155 90 GTEx DepMap Descartes 4.97 495.88
CADM1 0.0070657 94 GTEx DepMap Descartes 3.47 118.51


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8704.74
Median rank of genes in gene set: 10155
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PTN 0.0116536 12 GTEx DepMap Descartes 4.79 1010.25
TMEFF2 0.0061805 141 GTEx DepMap Descartes 2.16 200.64
SEMA3C 0.0058888 162 GTEx DepMap Descartes 1.09 82.93
ANXA2 0.0049409 244 GTEx DepMap Descartes 10.01 795.21
GNAI1 0.0038419 423 GTEx DepMap Descartes 1.17 33.09
SOX9 0.0035289 515 GTEx DepMap Descartes 0.11 5.56
DLC1 0.0034525 540 GTEx DepMap Descartes 1.38 55.33
GPC6 0.0032886 603 GTEx DepMap Descartes 0.20 8.90
SHC1 0.0031331 659 GTEx DepMap Descartes 1.24 101.96
EXTL2 0.0029046 739 GTEx DepMap Descartes 0.52 46.70
APP 0.0028949 745 GTEx DepMap Descartes 2.01 162.38
ENAH 0.0026256 892 GTEx DepMap Descartes 1.49 30.26
CKAP4 0.0024971 975 GTEx DepMap Descartes 1.08 104.37
ATP1B1 0.0023195 1091 GTEx DepMap Descartes 5.43 447.36
ITM2C 0.0021432 1200 GTEx DepMap Descartes 2.57 393.74
ROBO1 0.0021428 1201 GTEx DepMap Descartes 0.30 12.06
DKK3 0.0020946 1228 GTEx DepMap Descartes 0.58 14.23
PHLDA3 0.0019852 1313 GTEx DepMap Descartes 0.59 51.32
PTPRG 0.0019182 1366 GTEx DepMap Descartes 0.20 7.78
NES 0.0018627 1427 GTEx DepMap Descartes 1.07 53.15
FAT1 0.0017447 1551 GTEx DepMap Descartes 0.14 3.19
ARMCX2 0.0017056 1602 GTEx DepMap Descartes 0.37 38.07
SERPINE2 0.0015868 1747 GTEx DepMap Descartes 1.62 74.40
KCNK2 0.0015518 1793 GTEx DepMap Descartes 0.03 2.77
FAM3C 0.0015029 1857 GTEx DepMap Descartes 1.62 181.11
ASPH 0.0014926 1870 GTEx DepMap Descartes 0.59 26.36
TNS1 0.0014318 1949 GTEx DepMap Descartes 0.27 8.07
FZD7 0.0014111 1979 GTEx DepMap Descartes 0.03 3.26
PLK2 0.0014015 2000 GTEx DepMap Descartes 0.43 43.47
HS3ST3A1 0.0012726 2193 GTEx DepMap Descartes 0.07 3.71


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-02
Mean rank of genes in gene set: 5490.33
Median rank of genes in gene set: 5104
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GSTA4 0.0070574 95 GTEx DepMap Descartes 1.75 301.37
JAKMIP2 0.0033091 594 GTEx DepMap Descartes 0.82 24.74
FDPS 0.0030070 698 GTEx DepMap Descartes 2.47 303.12
PEG3 0.0027235 825 GTEx DepMap Descartes 0.53 NA
DNER 0.0025290 957 GTEx DepMap Descartes 1.08 87.88
HMGCS1 0.0023010 1101 GTEx DepMap Descartes 1.22 48.62
MSMO1 0.0018407 1441 GTEx DepMap Descartes 0.73 77.25
SLC1A2 0.0017367 1559 GTEx DepMap Descartes 0.23 5.30
FRMD5 0.0014545 1909 GTEx DepMap Descartes 0.14 8.82
PDE10A 0.0012887 2166 GTEx DepMap Descartes 0.17 4.75
FDXR 0.0010652 2547 GTEx DepMap Descartes 0.38 40.28
SGCZ 0.0009859 2735 GTEx DepMap Descartes 0.00 0.13
HMGCR 0.0009847 2737 GTEx DepMap Descartes 0.40 17.96
IGF1R 0.0008490 3021 GTEx DepMap Descartes 0.33 6.01
TM7SF2 0.0008326 3059 GTEx DepMap Descartes 0.40 49.60
SH3PXD2B 0.0007639 3245 GTEx DepMap Descartes 0.15 5.94
POR 0.0005103 4058 GTEx DepMap Descartes 0.43 47.31
CYB5B 0.0002702 5038 GTEx DepMap Descartes 0.84 51.02
DHCR24 0.0002360 5170 GTEx DepMap Descartes 0.41 12.99
GRAMD1B 0.0002314 5189 GTEx DepMap Descartes 0.05 1.59
SLC16A9 -0.0000606 6721 GTEx DepMap Descartes 0.08 4.71
FREM2 -0.0000795 6845 GTEx DepMap Descartes 0.00 0.00
SCAP -0.0001131 7122 GTEx DepMap Descartes 0.18 11.45
DHCR7 -0.0001531 7471 GTEx DepMap Descartes 0.19 13.10
BAIAP2L1 -0.0002874 8622 GTEx DepMap Descartes 0.00 0.00
NPC1 -0.0003329 8951 GTEx DepMap Descartes 0.09 4.75
STAR -0.0003524 9056 GTEx DepMap Descartes 0.02 1.71
INHA -0.0003717 9203 GTEx DepMap Descartes 0.04 6.07
LDLR -0.0004267 9556 GTEx DepMap Descartes 0.20 9.74
SH3BP5 -0.0005151 10034 GTEx DepMap Descartes 0.54 46.36


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.54e-15
Mean rank of genes in gene set: 1819.83
Median rank of genes in gene set: 441
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BASP1 0.0157331 3 GTEx DepMap Descartes 22.17 3551.72
ELAVL2 0.0137525 5 GTEx DepMap Descartes 4.90 379.38
TUBB2A 0.0136470 6 GTEx DepMap Descartes 23.94 4130.33
CCND1 0.0132328 7 GTEx DepMap Descartes 11.78 931.46
MAP1B 0.0120524 8 GTEx DepMap Descartes 30.10 678.27
TUBB2B 0.0120385 9 GTEx DepMap Descartes 33.41 4911.03
GAP43 0.0116845 11 GTEx DepMap Descartes 19.14 2862.35
STMN2 0.0115029 14 GTEx DepMap Descartes 79.25 11503.56
MLLT11 0.0105298 18 GTEx DepMap Descartes 28.77 3341.22
MAB21L1 0.0102853 21 GTEx DepMap Descartes 2.97 322.34
TUBA1A 0.0099876 25 GTEx DepMap Descartes 99.80 14028.06
CNTFR 0.0076679 64 GTEx DepMap Descartes 2.75 416.04
REEP1 0.0063398 137 GTEx DepMap Descartes 1.80 120.80
TMEFF2 0.0061805 141 GTEx DepMap Descartes 2.16 200.64
HS3ST5 0.0056494 175 GTEx DepMap Descartes 0.84 66.29
MARCH11 0.0056238 178 GTEx DepMap Descartes 1.12 NA
ISL1 0.0056092 181 GTEx DepMap Descartes 2.47 287.06
PLXNA4 0.0054432 195 GTEx DepMap Descartes 0.96 21.71
GAL 0.0051928 218 GTEx DepMap Descartes 7.19 2818.19
RGMB 0.0043188 340 GTEx DepMap Descartes 1.92 119.43
IL7 0.0037575 441 GTEx DepMap Descartes 2.04 294.70
CNKSR2 0.0036674 465 GTEx DepMap Descartes 0.29 11.29
PTCHD1 0.0036406 476 GTEx DepMap Descartes 0.50 12.77
EPHA6 0.0036124 486 GTEx DepMap Descartes 0.27 24.79
RBFOX1 0.0034621 534 GTEx DepMap Descartes 0.82 43.48
KCNB2 0.0025965 912 GTEx DepMap Descartes 0.24 17.82
SYNPO2 0.0024856 986 GTEx DepMap Descartes 0.30 5.62
EYA1 0.0024735 994 GTEx DepMap Descartes 0.23 13.74
SLC44A5 0.0022567 1128 GTEx DepMap Descartes 0.29 18.00
MAB21L2 0.0018798 1409 GTEx DepMap Descartes 0.34 28.42


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8449.11
Median rank of genes in gene set: 8726
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EFNB2 0.0016229 1700 GTEx DepMap Descartes 0.55 27.24
RAMP2 0.0008690 2971 GTEx DepMap Descartes 1.26 432.85
NR5A2 0.0005782 3820 GTEx DepMap Descartes 0.03 1.69
IRX3 0.0004324 4348 GTEx DepMap Descartes 0.04 5.19
MYRIP 0.0002469 5124 GTEx DepMap Descartes 0.04 1.62
HYAL2 0.0000258 6207 GTEx DepMap Descartes 0.28 17.84
CHRM3 -0.0000237 6494 GTEx DepMap Descartes 0.23 2.90
CDH13 -0.0000847 6887 GTEx DepMap Descartes 0.05 1.09
NOTCH4 -0.0001213 7203 GTEx DepMap Descartes 0.23 9.16
EHD3 -0.0001224 7214 GTEx DepMap Descartes 0.05 3.47
PODXL -0.0001828 7740 GTEx DepMap Descartes 0.06 2.13
TEK -0.0002474 8301 GTEx DepMap Descartes 0.01 0.55
GALNT15 -0.0002509 8325 GTEx DepMap Descartes 0.00 NA
CRHBP -0.0002599 8401 GTEx DepMap Descartes 0.00 0.55
ESM1 -0.0002605 8407 GTEx DepMap Descartes 0.01 1.10
KDR -0.0002743 8523 GTEx DepMap Descartes 0.00 0.10
RASIP1 -0.0002863 8610 GTEx DepMap Descartes 0.02 0.68
SHANK3 -0.0002880 8627 GTEx DepMap Descartes 0.04 1.40
CYP26B1 -0.0002903 8653 GTEx DepMap Descartes 0.01 0.19
CLDN5 -0.0003105 8799 GTEx DepMap Descartes 0.16 20.61
FLT4 -0.0003785 9252 GTEx DepMap Descartes 0.00 0.00
SHE -0.0004410 9635 GTEx DepMap Descartes 0.01 0.31
CEACAM1 -0.0004540 9706 GTEx DepMap Descartes 0.02 1.41
KANK3 -0.0004587 9729 GTEx DepMap Descartes 0.00 0.56
BTNL9 -0.0005074 9996 GTEx DepMap Descartes 0.01 0.26
SLCO2A1 -0.0005221 10065 GTEx DepMap Descartes 0.00 0.11
F8 -0.0005337 10126 GTEx DepMap Descartes 0.01 0.34
MMRN2 -0.0005561 10234 GTEx DepMap Descartes 0.01 0.68
CALCRL -0.0005586 10244 GTEx DepMap Descartes 0.01 0.29
NPR1 -0.0005638 10264 GTEx DepMap Descartes 0.00 0.00


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9206.7
Median rank of genes in gene set: 10078.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PRICKLE1 0.0018825 1407 GTEx DepMap Descartes 0.25 13.17
PCDH18 0.0012595 2211 GTEx DepMap Descartes 0.06 3.94
CDH11 0.0004890 4143 GTEx DepMap Descartes 0.10 3.89
ELN 0.0004837 4159 GTEx DepMap Descartes 1.34 108.08
HHIP 0.0004498 4272 GTEx DepMap Descartes 0.03 1.04
GAS2 -0.0000146 6442 GTEx DepMap Descartes 0.02 0.78
LAMC3 -0.0001105 7097 GTEx DepMap Descartes 0.00 0.00
FREM1 -0.0001544 7482 GTEx DepMap Descartes 0.02 0.67
GLI2 -0.0001694 7623 GTEx DepMap Descartes 0.00 0.13
ADAMTS2 -0.0002014 7895 GTEx DepMap Descartes 0.06 1.58
COL27A1 -0.0002833 8587 GTEx DepMap Descartes 0.00 0.08
ITGA11 -0.0003394 8985 GTEx DepMap Descartes 0.01 0.32
EDNRA -0.0003609 9117 GTEx DepMap Descartes 0.01 0.47
ABCC9 -0.0003847 9303 GTEx DepMap Descartes 0.01 0.12
IGFBP3 -0.0004323 9596 GTEx DepMap Descartes 0.09 7.95
BICC1 -0.0004440 9647 GTEx DepMap Descartes 0.04 2.04
DKK2 -0.0004536 9702 GTEx DepMap Descartes 0.00 0.17
ACTA2 -0.0004805 9861 GTEx DepMap Descartes 0.05 6.78
CLDN11 -0.0004819 9871 GTEx DepMap Descartes 0.02 1.65
RSPO3 -0.0004840 9881 GTEx DepMap Descartes 0.00 NA
SCARA5 -0.0004889 9902 GTEx DepMap Descartes 0.00 0.00
SFRP2 -0.0005119 10018 GTEx DepMap Descartes 0.01 2.31
ADAMTSL3 -0.0005366 10139 GTEx DepMap Descartes 0.01 0.16
PCOLCE -0.0005381 10145 GTEx DepMap Descartes 0.74 127.01
PAMR1 -0.0005488 10190 GTEx DepMap Descartes 0.01 1.31
C7 -0.0005577 10241 GTEx DepMap Descartes 0.01 0.37
ABCA6 -0.0006006 10430 GTEx DepMap Descartes 0.00 0.00
COL6A3 -0.0006478 10631 GTEx DepMap Descartes 0.12 2.47
LRRC17 -0.0006705 10714 GTEx DepMap Descartes 0.01 0.84
CD248 -0.0006747 10728 GTEx DepMap Descartes 0.02 1.85


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.09e-04
Mean rank of genes in gene set: 4311.34
Median rank of genes in gene set: 3352
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCSK1N 0.0106874 16 GTEx DepMap Descartes 15.61 4456.82
CHGB 0.0068868 101 GTEx DepMap Descartes 13.05 1536.58
KCTD16 0.0064740 125 GTEx DepMap Descartes 1.04 20.31
GRID2 0.0041161 372 GTEx DepMap Descartes 0.15 7.69
SPOCK3 0.0036367 478 GTEx DepMap Descartes 0.46 33.18
CDH18 0.0035830 497 GTEx DepMap Descartes 0.21 14.30
GRM7 0.0033859 564 GTEx DepMap Descartes 0.10 9.14
ARC 0.0023627 1063 GTEx DepMap Descartes 0.73 67.50
UNC80 0.0022650 1123 GTEx DepMap Descartes 0.44 8.14
ROBO1 0.0021428 1201 GTEx DepMap Descartes 0.30 12.06
CDH12 0.0020170 1285 GTEx DepMap Descartes 0.15 9.58
SLC18A1 0.0016991 1614 GTEx DepMap Descartes 0.93 83.21
FGF14 0.0016773 1643 GTEx DepMap Descartes 0.33 6.60
TENM1 0.0015624 1779 GTEx DepMap Descartes 0.17 NA
PCSK2 0.0014616 1899 GTEx DepMap Descartes 0.09 5.26
FAM155A 0.0014515 1917 GTEx DepMap Descartes 0.27 8.17
CNTN3 0.0014096 1984 GTEx DepMap Descartes 0.01 0.47
C1QL1 0.0008729 2963 GTEx DepMap Descartes 1.08 168.26
HTATSF1 0.0008318 3063 GTEx DepMap Descartes 0.82 75.65
TBX20 0.0006331 3641 GTEx DepMap Descartes 0.04 5.54
CHGA 0.0005540 3898 GTEx DepMap Descartes 2.68 322.72
NTNG1 0.0004269 4362 GTEx DepMap Descartes 0.13 6.33
PACRG 0.0003049 4888 GTEx DepMap Descartes 0.18 25.33
AGBL4 0.0002091 5280 GTEx DepMap Descartes 0.02 1.43
SLC24A2 0.0000791 5917 GTEx DepMap Descartes 0.02 0.35
LAMA3 0.0000267 6199 GTEx DepMap Descartes 0.05 1.18
DGKK 0.0000095 6294 GTEx DepMap Descartes 0.06 2.01
SORCS3 -0.0001726 7653 GTEx DepMap Descartes 0.01 0.21
PENK -0.0002165 8007 GTEx DepMap Descartes 0.00 0.00
CCSER1 -0.0002215 8059 GTEx DepMap Descartes 0.04 NA


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.60e-01
Mean rank of genes in gene set: 7454.17
Median rank of genes in gene set: 8258
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SNCA 0.0057544 168 GTEx DepMap Descartes 1.42 115.48
SPTB 0.0015541 1789 GTEx DepMap Descartes 0.11 3.52
ANK1 0.0014299 1953 GTEx DepMap Descartes 0.24 7.76
RAPGEF2 0.0010684 2536 GTEx DepMap Descartes 0.26 9.55
XPO7 0.0007295 3340 GTEx DepMap Descartes 0.38 21.23
TFR2 0.0007144 3386 GTEx DepMap Descartes 0.18 14.95
TRAK2 0.0007090 3400 GTEx DepMap Descartes 0.28 10.65
TMCC2 0.0006996 3424 GTEx DepMap Descartes 0.15 9.65
FECH 0.0003461 4707 GTEx DepMap Descartes 0.34 11.34
TSPAN5 0.0002367 5168 GTEx DepMap Descartes 0.70 42.16
ABCB10 0.0002084 5283 GTEx DepMap Descartes 0.17 10.33
SLC4A1 -0.0001459 7406 GTEx DepMap Descartes 0.01 0.46
ALAS2 -0.0001818 7731 GTEx DepMap Descartes 0.00 0.00
RHD -0.0002011 7891 GTEx DepMap Descartes 0.01 0.29
RGS6 -0.0002430 8258 GTEx DepMap Descartes 0.00 0.00
SLC25A21 -0.0003027 8737 GTEx DepMap Descartes 0.00 0.00
GCLC -0.0003599 9113 GTEx DepMap Descartes 0.09 5.11
SELENBP1 -0.0003835 9292 GTEx DepMap Descartes 0.01 0.61
CPOX -0.0004340 9602 GTEx DepMap Descartes 0.05 4.09
EPB41 -0.0005383 10146 GTEx DepMap Descartes 0.37 16.55
MARCH3 -0.0006349 10585 GTEx DepMap Descartes 0.03 NA
MICAL2 -0.0006569 10667 GTEx DepMap Descartes 0.02 1.03
SOX6 -0.0006681 10708 GTEx DepMap Descartes 0.16 4.02
DENND4A -0.0008099 11140 GTEx DepMap Descartes 0.18 5.69
SPECC1 -0.0008169 11162 GTEx DepMap Descartes 0.00 0.10
SLC25A37 -0.0012074 11880 GTEx DepMap Descartes 0.49 23.08
CAT -0.0013165 12005 GTEx DepMap Descartes 0.19 25.07
BLVRB -0.0016576 12232 GTEx DepMap Descartes 0.02 3.45
GYPC -0.0025223 12462 GTEx DepMap Descartes 0.02 5.57
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10422.71
Median rank of genes in gene set: 11551
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FMN1 0.0032369 614 GTEx DepMap Descartes 0.47 11.09
CD163L1 0.0032059 629 GTEx DepMap Descartes 1.59 95.08
HRH1 0.0007922 3165 GTEx DepMap Descartes 0.08 6.26
SPP1 0.0000354 6151 GTEx DepMap Descartes 2.67 564.03
WWP1 -0.0001272 7259 GTEx DepMap Descartes 0.15 8.64
CTSB -0.0004361 9614 GTEx DepMap Descartes 1.98 149.24
RBPJ -0.0004568 9717 GTEx DepMap Descartes 0.97 37.46
SLC1A3 -0.0005065 9993 GTEx DepMap Descartes 0.01 0.70
ATP8B4 -0.0005313 10110 GTEx DepMap Descartes 0.00 0.00
MERTK -0.0005397 10153 GTEx DepMap Descartes 0.00 0.00
MSR1 -0.0006015 10433 GTEx DepMap Descartes 0.00 0.00
SLCO2B1 -0.0006180 10505 GTEx DepMap Descartes 0.00 0.19
LGMN -0.0006531 10651 GTEx DepMap Descartes 0.28 40.66
RGL1 -0.0006587 10675 GTEx DepMap Descartes 0.02 1.29
ADAP2 -0.0007946 11097 GTEx DepMap Descartes 0.00 0.22
SLC9A9 -0.0008123 11146 GTEx DepMap Descartes 0.00 0.45
ABCA1 -0.0008860 11354 GTEx DepMap Descartes 0.02 0.24
SFMBT2 -0.0009116 11411 GTEx DepMap Descartes 0.01 0.16
MS4A4A -0.0009712 11529 GTEx DepMap Descartes 0.01 2.71
AXL -0.0009967 11573 GTEx DepMap Descartes 0.00 0.04
ITPR2 -0.0010343 11638 GTEx DepMap Descartes 0.03 0.68
CD163 -0.0010874 11728 GTEx DepMap Descartes 0.00 0.17
FGD2 -0.0011404 11789 GTEx DepMap Descartes 0.01 0.70
CSF1R -0.0012036 11873 GTEx DepMap Descartes 0.00 0.00
MARCH1 -0.0012668 11957 GTEx DepMap Descartes 0.03 NA
TGFBI -0.0013579 12033 GTEx DepMap Descartes 0.00 0.52
CTSD -0.0013693 12043 GTEx DepMap Descartes 0.47 56.98
CD14 -0.0014630 12114 GTEx DepMap Descartes 0.02 3.17
CPVL -0.0015184 12156 GTEx DepMap Descartes 0.00 1.09
CYBB -0.0015681 12190 GTEx DepMap Descartes 0.00 0.18


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.78e-01
Mean rank of genes in gene set: 5770.95
Median rank of genes in gene set: 5951.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PTN 0.0116536 12 GTEx DepMap Descartes 4.79 1010.25
NRXN1 0.0102540 22 GTEx DepMap Descartes 1.39 45.21
SLC35F1 0.0078955 57 GTEx DepMap Descartes 0.34 20.93
MARCKS 0.0077907 63 GTEx DepMap Descartes 11.48 757.00
PAG1 0.0060239 150 GTEx DepMap Descartes 2.03 62.55
GFRA3 0.0056167 179 GTEx DepMap Descartes 2.82 406.39
SFRP1 0.0050844 230 GTEx DepMap Descartes 2.46 154.00
SOX5 0.0042066 354 GTEx DepMap Descartes 0.15 7.30
DST 0.0040102 386 GTEx DepMap Descartes 3.27 41.21
PPP2R2B 0.0036782 460 GTEx DepMap Descartes 0.66 16.78
XKR4 0.0031289 661 GTEx DepMap Descartes 0.16 2.35
ERBB4 0.0026223 893 GTEx DepMap Descartes 0.22 5.49
SCN7A 0.0020965 1227 GTEx DepMap Descartes 0.76 29.18
MDGA2 0.0019734 1320 GTEx DepMap Descartes 0.04 3.29
IL1RAPL1 0.0016176 1704 GTEx DepMap Descartes 0.01 1.04
IL1RAPL2 0.0013016 2146 GTEx DepMap Descartes 0.00 0.37
TRPM3 0.0012727 2192 GTEx DepMap Descartes 0.17 4.08
SORCS1 0.0007411 3314 GTEx DepMap Descartes 0.17 5.02
NRXN3 0.0005186 4022 GTEx DepMap Descartes 0.04 0.70
PMP22 0.0002323 5186 GTEx DepMap Descartes 5.68 800.35
GRIK3 0.0002037 5305 GTEx DepMap Descartes 0.01 0.20
LRRTM4 0.0001040 5778 GTEx DepMap Descartes 0.39 26.48
PLCE1 0.0000402 6125 GTEx DepMap Descartes 0.10 2.13
ERBB3 -0.0001022 7035 GTEx DepMap Descartes 0.02 0.66
MPZ -0.0001125 7109 GTEx DepMap Descartes 0.02 5.14
PTPRZ1 -0.0002161 8004 GTEx DepMap Descartes 0.00 0.00
COL25A1 -0.0002373 8199 GTEx DepMap Descartes 0.00 0.00
HMGA2 -0.0002784 8556 GTEx DepMap Descartes 0.00 0.00
LAMB1 -0.0003494 9033 GTEx DepMap Descartes 0.22 10.26
PLP1 -0.0004432 9642 GTEx DepMap Descartes 0.00 0.00


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9526.8
Median rank of genes in gene set: 10780
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DOK6 0.0102090 23 GTEx DepMap Descartes 0.51 18.61
PRKAR2B 0.0060844 147 GTEx DepMap Descartes 1.44 107.69
ACTB 0.0016360 1687 GTEx DepMap Descartes 65.84 8275.09
STON2 0.0008812 2942 GTEx DepMap Descartes 0.13 8.11
MED12L 0.0002534 5102 GTEx DepMap Descartes 0.02 0.46
ITGA2B 0.0002074 5287 GTEx DepMap Descartes 0.04 3.01
RAB27B 0.0001980 5329 GTEx DepMap Descartes 0.20 7.80
VCL 0.0001855 5377 GTEx DepMap Descartes 0.18 6.07
ANGPT1 -0.0001855 7762 GTEx DepMap Descartes 0.01 0.35
ARHGAP6 -0.0002622 8421 GTEx DepMap Descartes 0.00 0.26
ITGB3 -0.0002654 8440 GTEx DepMap Descartes 0.00 0.00
SLC24A3 -0.0002699 8493 GTEx DepMap Descartes 0.00 0.00
TRPC6 -0.0002765 8537 GTEx DepMap Descartes 0.00 0.00
GP1BA -0.0003466 9020 GTEx DepMap Descartes 0.01 0.68
INPP4B -0.0003526 9057 GTEx DepMap Descartes 0.08 2.60
ZYX -0.0003800 9262 GTEx DepMap Descartes 0.67 83.32
MMRN1 -0.0004279 9565 GTEx DepMap Descartes 0.00 0.20
PDE3A -0.0004720 9811 GTEx DepMap Descartes 0.05 1.44
TUBB1 -0.0004767 9832 GTEx DepMap Descartes 0.02 2.07
MYLK -0.0004866 9891 GTEx DepMap Descartes 0.02 0.48
MCTP1 -0.0006243 10535 GTEx DepMap Descartes 0.02 1.45
LTBP1 -0.0006260 10542 GTEx DepMap Descartes 0.00 0.00
P2RX1 -0.0006909 10780 GTEx DepMap Descartes 0.00 0.00
HIPK2 -0.0007636 11014 GTEx DepMap Descartes 0.41 6.18
UBASH3B -0.0007720 11034 GTEx DepMap Descartes 0.03 1.12
PSTPIP2 -0.0008085 11137 GTEx DepMap Descartes 0.01 0.85
GSN -0.0008322 11213 GTEx DepMap Descartes 0.22 8.65
CD84 -0.0009324 11462 GTEx DepMap Descartes 0.01 0.15
CD9 -0.0011944 11860 GTEx DepMap Descartes 1.82 270.34
ACTN1 -0.0011976 11863 GTEx DepMap Descartes 0.40 23.07


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10003.17
Median rank of genes in gene set: 11933.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMSB10 0.0062481 140 GTEx DepMap Descartes 119.44 70330.92
NCALD 0.0029277 730 GTEx DepMap Descartes 0.72 56.09
FYN 0.0017520 1546 GTEx DepMap Descartes 2.72 213.17
GNG2 0.0014546 1908 GTEx DepMap Descartes 1.68 129.65
TOX 0.0013763 2033 GTEx DepMap Descartes 0.34 27.84
STK39 0.0011767 2356 GTEx DepMap Descartes 0.77 58.97
BCL2 0.0004874 4148 GTEx DepMap Descartes 0.44 16.94
SCML4 0.0002833 4991 GTEx DepMap Descartes 0.33 21.00
RAP1GAP2 -0.0002865 8611 GTEx DepMap Descartes 0.34 13.34
ABLIM1 -0.0003809 9269 GTEx DepMap Descartes 0.25 8.45
BACH2 -0.0006805 10754 GTEx DepMap Descartes 0.19 5.94
PITPNC1 -0.0008469 11243 GTEx DepMap Descartes 0.18 6.63
ITPKB -0.0008660 11298 GTEx DepMap Descartes 0.01 0.12
SORL1 -0.0008692 11310 GTEx DepMap Descartes 0.32 8.32
FOXP1 -0.0008914 11370 GTEx DepMap Descartes 1.50 45.65
DOCK10 -0.0009266 11452 GTEx DepMap Descartes 0.11 4.89
SAMD3 -0.0010036 11579 GTEx DepMap Descartes 0.01 0.47
CCL5 -0.0011239 11777 GTEx DepMap Descartes 0.06 9.95
ANKRD44 -0.0011469 11802 GTEx DepMap Descartes 0.19 7.78
SKAP1 -0.0011542 11814 GTEx DepMap Descartes 0.01 1.32
MCTP2 -0.0012264 11901 GTEx DepMap Descartes 0.01 0.09
PDE3B -0.0012762 11966 GTEx DepMap Descartes 0.08 3.22
PLEKHA2 -0.0013191 12008 GTEx DepMap Descartes 0.04 2.21
LEF1 -0.0013240 12011 GTEx DepMap Descartes 0.01 0.33
ARID5B -0.0013345 12017 GTEx DepMap Descartes 0.21 10.44
EVL -0.0014812 12125 GTEx DepMap Descartes 1.20 97.86
PRKCH -0.0014941 12136 GTEx DepMap Descartes 0.01 1.01
CELF2 -0.0016694 12238 GTEx DepMap Descartes 0.86 27.77
ARHGAP15 -0.0017528 12277 GTEx DepMap Descartes 0.00 0.19
IKZF1 -0.0017544 12279 GTEx DepMap Descartes 0.01 0.31


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-03
Mean rank of genes in gene set: 303
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRDX2 0.0047048 271 GTEx DepMap Descartes 7.17 1150.62
KCNH2 0.0043315 335 GTEx DepMap Descartes 0.75 45.65


T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.07e-02
Mean rank of genes in gene set: 1050.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PANX2 0.0026447 877 GTEx DepMap Descartes 0.41 38.53
INPP5J 0.0021002 1224 GTEx DepMap Descartes 0.12 12.36


B cells: Transitional B cells (model markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.36e-02
Mean rank of genes in gene set: 79
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GNG3 0.0073107 79 GTEx DepMap Descartes 4.4 1467.58


No detectable expression in this dataset: OR2A25