Program: 31. Neuroblastoma: Adrenergic #2.

Program: 31. Neuroblastoma: Adrenergic #2.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 RAMP1 0.0106459 receptor activity modifying protein 1 GTEx DepMap Descartes 8.83 2683.59
2 GNAS 0.0103189 GNAS complex locus GTEx DepMap Descartes 49.03 3002.14
3 GPR22 0.0096222 G protein-coupled receptor 22 GTEx DepMap Descartes 1.89 168.94
4 CNTN1 0.0095352 contactin 1 GTEx DepMap Descartes 2.80 124.92
5 TUBA1A 0.0087402 tubulin alpha 1a GTEx DepMap Descartes 56.03 7014.33
6 NRCAM 0.0082015 neuronal cell adhesion molecule GTEx DepMap Descartes 1.63 61.85
7 TUBB2A 0.0080134 tubulin beta 2A class IIa GTEx DepMap Descartes 7.94 1138.56
8 DLC1 0.0079274 DLC1 Rho GTPase activating protein GTEx DepMap Descartes 2.96 105.20
9 CALY 0.0076323 calcyon neuron specific vesicular protein GTEx DepMap Descartes 2.08 223.11
10 PHOX2A 0.0076245 paired like homeobox 2A GTEx DepMap Descartes 12.20 1718.71
11 NCOA7 0.0076094 nuclear receptor coactivator 7 GTEx DepMap Descartes 3.23 NA
12 PCBD1 0.0076032 pterin-4 alpha-carbinolamine dehydratase 1 GTEx DepMap Descartes 3.97 1209.59
13 SCG5 0.0075272 secretogranin V GTEx DepMap Descartes 5.09 1013.54
14 ANXA2 0.0074507 annexin A2 GTEx DepMap Descartes 6.60 461.79
15 RBP1 0.0073958 retinol binding protein 1 GTEx DepMap Descartes 7.06 952.14
16 MXRA7 0.0072653 matrix remodeling associated 7 GTEx DepMap Descartes 3.10 135.69
17 TH 0.0072462 tyrosine hydroxylase GTEx DepMap Descartes 4.46 601.30
18 MAP7 0.0071312 microtubule associated protein 7 GTEx DepMap Descartes 1.74 104.42
19 CD9 0.0070738 CD9 molecule GTEx DepMap Descartes 3.35 484.22
20 PPP1R1A 0.0070617 protein phosphatase 1 regulatory inhibitor subunit 1A GTEx DepMap Descartes 0.81 80.83
21 TLN2 0.0069236 talin 2 GTEx DepMap Descartes 2.34 49.48
22 SLCO3A1 0.0068498 solute carrier organic anion transporter family member 3A1 GTEx DepMap Descartes 1.78 90.01
23 FAIM2 0.0067529 Fas apoptotic inhibitory molecule 2 GTEx DepMap Descartes 2.34 127.93
24 EID1 0.0066399 EP300 interacting inhibitor of differentiation 1 GTEx DepMap Descartes 7.13 845.47
25 CALM2 0.0066340 calmodulin 2 GTEx DepMap Descartes 21.05 1130.65
26 DBH 0.0065700 dopamine beta-hydroxylase GTEx DepMap Descartes 7.82 731.29
27 SYT1 0.0064980 synaptotagmin 1 GTEx DepMap Descartes 5.38 283.48
28 SFRP1 0.0064956 secreted frizzled related protein 1 GTEx DepMap Descartes 2.21 127.22
29 TPM1 0.0064546 tropomyosin 1 GTEx DepMap Descartes 3.27 214.54
30 TUBB2B 0.0064292 tubulin beta 2B class IIb GTEx DepMap Descartes 28.37 3487.53
31 PIK3R1 0.0064259 phosphoinositide-3-kinase regulatory subunit 1 GTEx DepMap Descartes 3.35 125.73
32 ARHGDIG 0.0064258 Rho GDP dissociation inhibitor gamma GTEx DepMap Descartes 1.43 280.64
33 RAB3C 0.0063772 RAB3C, member RAS oncogene family GTEx DepMap Descartes 1.67 48.03
34 NACA 0.0063195 nascent polypeptide associated complex subunit alpha GTEx DepMap Descartes 34.43 1288.69
35 CHGB 0.0062484 chromogranin B GTEx DepMap Descartes 8.49 870.17
36 CNTNAP2 0.0062390 contactin associated protein 2 GTEx DepMap Descartes 4.01 99.14
37 ALCAM 0.0060979 activated leukocyte cell adhesion molecule GTEx DepMap Descartes 2.84 148.54
38 QPCT 0.0060805 glutaminyl-peptide cyclotransferase GTEx DepMap Descartes 0.78 121.42
39 YWHAQ 0.0059650 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta GTEx DepMap Descartes 7.96 880.86
40 MAP1LC3A 0.0059162 microtubule associated protein 1 light chain 3 alpha GTEx DepMap Descartes 2.88 726.21
41 SHC1 0.0058792 SHC adaptor protein 1 GTEx DepMap Descartes 1.45 104.65
42 SRP14 0.0058212 signal recognition particle 14 GTEx DepMap Descartes 12.75 2777.10
43 PGM2L1 0.0058052 phosphoglucomutase 2 like 1 GTEx DepMap Descartes 2.20 62.79
44 DCTN2 0.0057883 dynactin subunit 2 GTEx DepMap Descartes 3.61 437.99
45 ACTN2 0.0057676 actinin alpha 2 GTEx DepMap Descartes 0.97 47.89
46 PCLO 0.0057542 piccolo presynaptic cytomatrix protein GTEx DepMap Descartes 1.50 18.87
47 MEIS2 0.0057241 Meis homeobox 2 GTEx DepMap Descartes 3.03 140.41
48 COX7A2L 0.0056672 cytochrome c oxidase subunit 7A2 like GTEx DepMap Descartes 5.68 449.24
49 DST 0.0056610 dystonin GTEx DepMap Descartes 3.63 40.82
50 PPDPF 0.0056507 pancreatic progenitor cell differentiation and proliferation factor GTEx DepMap Descartes 8.15 2431.25


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UMAP plots showing activity of gene expression program identified in GEP 31. Neuroblastoma: Adrenergic #2:

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
MENON_FETAL_KIDNEY_3_STROMAL_CELLS 8.68e-10 32.57 12.75 2.91e-07 5.82e-07
8GNAS, TUBA1A, RBP1, SFRP1, TPM1, ALCAM, MEIS2, DST
 81
DESCARTES_FETAL_INTESTINE_ENS_NEURONS 5.03e-10 20.82 9.11 2.91e-07 3.37e-07
10GPR22, CNTN1, TUBB2A, PHOX2A, TH, DBH, SYT1, TUBB2B, ARHGDIG, CNTNAP2
 160
DESCARTES_FETAL_PANCREAS_ENS_NEURONS 1.20e-08 17.81 7.48 2.01e-06 8.05e-06
9GPR22, TUBA1A, TUBB2A, PHOX2A, DBH, SYT1, TUBB2B, ARHGDIG, CNTNAP2
 163
BUSSLINGER_GASTRIC_G_CELLS 2.24e-06 18.51 6.29 2.13e-04 1.50e-03
6SCG5, CHGB, QPCT, PCLO, MEIS2, DST
 98
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_IMMATURE_NEURONS 1.10e-06 15.41 5.74 1.23e-04 7.36e-04
7TUBA1A, TUBB2A, SCG5, CALM2, SYT1, TUBB2B, PCLO
 139
DESCARTES_FETAL_HEART_VISCERAL_NEURONS 2.29e-05 16.92 5.11 1.02e-03 1.53e-02
5PHOX2A, TH, DBH, RAB3C, CHGB
 87
HU_FETAL_RETINA_RGC 7.94e-09 10.22 4.95 1.78e-06 5.33e-06
13TUBA1A, NRCAM, TUBB2A, SCG5, PPP1R1A, CALM2, SYT1, TUBB2B, CHGB, ALCAM, YWHAQ, PGM2L1, DCTN2
 443
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_GLOBOSE_BASAL_CELLS 3.53e-04 24.91 4.72 7.18e-03 2.37e-01
3TUBA1A, RBP1, TUBB2B
 35
HU_FETAL_RETINA_AMACRINE 1.17e-04 18.10 4.59 3.72e-03 7.82e-02
4TUBB2A, SYT1, TUBB2B, MEIS2
 64
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 2.05e-07 9.33 4.27 2.75e-05 1.38e-04
11TUBA1A, TUBB2A, PHOX2A, SCG5, TLN2, FAIM2, DBH, TUBB2B, CNTNAP2, ALCAM, MAP1LC3A
 389
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MATURE_NEURONS 7.70e-06 11.30 4.23 4.94e-04 5.17e-03
7TUBA1A, PPP1R1A, FAIM2, CALM2, SYT1, TUBB2B, QPCT
 187
BUSSLINGER_GASTRIC_X_CELLS 8.83e-06 11.06 4.14 4.94e-04 5.93e-03
7TUBA1A, CALY, RBP1, PPP1R1A, CHGB, PCLO, DST
 191
HU_FETAL_RETINA_HORIZONTAL 5.25e-04 21.53 4.11 1.01e-02 3.52e-01
3TUBA1A, TUBB2B, CNTNAP2
 40
DESCARTES_FETAL_STOMACH_ENS_NEURONS 2.04e-04 15.52 3.95 5.48e-03 1.37e-01
4TUBB2A, SYT1, TUBB2B, CNTNAP2
 74
GAO_LARGE_INTESTINE_ADULT_CA_ENTEROENDOCRINE_CELLS 2.71e-06 9.06 3.84 2.13e-04 1.82e-03
9RAMP1, TUBA1A, SCG5, SYT1, TUBB2B, RAB3C, CHGB, QPCT, PCLO
 312
LAKE_ADULT_KIDNEY_C9_THIN_ASCENDING_LIMB 8.26e-06 9.16 3.68 4.94e-04 5.54e-03
8GNAS, NCOA7, ANXA2, CD9, EID1, TPM1, NACA, SRP14
 268
AIZARANI_LIVER_C33_STELLATE_CELLS_2 1.33e-04 11.47 3.49 4.05e-03 8.91e-02
5GNAS, DLC1, MXRA7, TPM1, DST
 126
FAN_EMBRYONIC_CTX_BIG_GROUPS_EXCITATORY_NEURON 8.44e-04 18.11 3.48 1.45e-02 5.66e-01
3ACTN2, PCLO, MEIS2
 47
ZHONG_PFC_C8_UNKNOWN_NEUROD2_POS_INTERNEURON 3.32e-04 13.58 3.47 7.18e-03 2.23e-01
4CNTN1, PIK3R1, ALCAM, ACTN2
 84
TRAVAGLINI_LUNG_NEUROENDOCRINE_CELL 1.43e-04 11.29 3.44 4.17e-03 9.59e-02
5CALY, SCG5, SYT1, TUBB2B, CHGB
 128

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_CHOLESTEROL_HOMEOSTASIS 3.47e-02 7.23 0.84 6.90e-01 1.00e+00
2CD9, ALCAM
 74
HALLMARK_APICAL_JUNCTION 4.35e-02 4.05 0.80 6.90e-01 1.00e+00
3CNTN1, SHC1, ACTN2
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 4.35e-02 4.05 0.80 6.90e-01 1.00e+00
3SFRP1, TPM1, DST
 200
HALLMARK_PROTEIN_SECRETION 5.52e-02 5.54 0.64 6.90e-01 1.00e+00
2GNAS, DST
 96
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 7.33e-02 4.69 0.55 7.11e-01 1.00e+00
2TUBB2A, SHC1
 113
HALLMARK_SPERMATOGENESIS 9.90e-02 3.92 0.46 7.11e-01 1.00e+00
2SCG5, MAP7
 135
HALLMARK_UV_RESPONSE_DN 1.10e-01 3.67 0.43 7.11e-01 1.00e+00
2DLC1, ANXA2
 144
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2DLC1, TUBB2B
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2TH, CD9
 200
HALLMARK_COMPLEMENT 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2ACTN2, PCLO
 200
HALLMARK_KRAS_SIGNALING_UP 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2SCG5, MAP7
 200
HALLMARK_HEDGEHOG_SIGNALING 1.34e-01 7.29 0.18 7.11e-01 1.00e+00
1NRCAM
 36
HALLMARK_PANCREAS_BETA_CELLS 1.47e-01 6.54 0.16 7.11e-01 1.00e+00
1SRP14
 40
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 9.43e-01 1.00e+00
1CD9
 87
HALLMARK_INTERFERON_ALPHA_RESPONSE 3.20e-01 2.66 0.07 9.43e-01 1.00e+00
1NCOA7
 97
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 9.43e-01 1.00e+00
1MAP7
 100
HALLMARK_BILE_ACID_METABOLISM 3.59e-01 2.30 0.06 9.43e-01 1.00e+00
1RBP1
 112
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 9.43e-01 1.00e+00
1CD9
 138
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 9.43e-01 1.00e+00
1PCBD1
 158
HALLMARK_MITOTIC_SPINDLE 5.45e-01 1.29 0.03 9.43e-01 1.00e+00
1DST
 199

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 6.91e-05 20.88 5.27 1.29e-02 1.29e-02
4TUBA1A, TUBB2A, TUBB2B, YWHAQ
 56
KEGG_GAP_JUNCTION 4.31e-04 12.63 3.23 4.01e-02 8.02e-02
4GNAS, TUBA1A, TUBB2A, TUBB2B
 90
KEGG_GLIOMA 2.15e-03 12.86 2.49 8.01e-02 4.01e-01
3CALM2, PIK3R1, SHC1
 65
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 1.51e-03 8.91 2.29 8.01e-02 2.80e-01
4CALM2, PIK3R1, YWHAQ, SHC1
 126
KEGG_CELL_ADHESION_MOLECULES_CAMS 1.83e-03 8.43 2.17 8.01e-02 3.41e-01
4CNTN1, NRCAM, CNTNAP2, ALCAM
 133
KEGG_TYROSINE_METABOLISM 1.20e-02 13.01 1.48 2.72e-01 1.00e+00
2TH, DBH
 42
KEGG_FOCAL_ADHESION 7.58e-03 5.57 1.44 2.35e-01 1.00e+00
4TLN2, PIK3R1, SHC1, ACTN2
 199
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.31e-02 12.39 1.41 2.72e-01 1.00e+00
2GNAS, DCTN2
 44
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 1.05e-02 7.12 1.40 2.72e-01 1.00e+00
3RAMP1, GNAS, CALM2
 115
KEGG_INSULIN_SIGNALING_PATHWAY 1.67e-02 5.95 1.17 3.10e-01 1.00e+00
3CALM2, PIK3R1, SHC1
 137
KEGG_LONG_TERM_POTENTIATION 3.13e-02 7.66 0.88 5.18e-01 1.00e+00
2PPP1R1A, CALM2
 70
KEGG_CHRONIC_MYELOID_LEUKEMIA 3.38e-02 7.33 0.85 5.18e-01 1.00e+00
2PIK3R1, SHC1
 73
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 3.64e-02 7.04 0.81 5.18e-01 1.00e+00
2CALM2, PIK3R1
 76
KEGG_CARDIAC_MUSCLE_CONTRACTION 3.90e-02 6.76 0.78 5.18e-01 1.00e+00
2TPM1, COX7A2L
 79
KEGG_ERBB_SIGNALING_PATHWAY 4.64e-02 6.13 0.71 5.73e-01 1.00e+00
2PIK3R1, SHC1
 87
KEGG_DILATED_CARDIOMYOPATHY 4.93e-02 5.92 0.69 5.73e-01 1.00e+00
2GNAS, TPM1
 90
KEGG_GNRH_SIGNALING_PATHWAY 6.04e-02 5.26 0.61 6.24e-01 1.00e+00
2GNAS, CALM2
 101
KEGG_MELANOGENESIS 6.04e-02 5.26 0.61 6.24e-01 1.00e+00
2GNAS, CALM2
 101
KEGG_OOCYTE_MEIOSIS 7.33e-02 4.69 0.55 7.13e-01 1.00e+00
2CALM2, YWHAQ
 113
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 7.67e-02 4.57 0.53 7.13e-01 1.00e+00
2PIK3R1, ACTN2
 116

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr15q22 1.28e-02 6.59 1.29 1.00e+00 1.00e+00
3ANXA2, TLN2, TPM1
 124
chr12q13 1.99e-02 3.46 1.06 1.00e+00 1.00e+00
5TUBA1A, PPP1R1A, FAIM2, NACA, DCTN2
 407
chr2p21 3.99e-02 6.67 0.77 1.00e+00 1.00e+00
2CALM2, COX7A2L
 80
chr6p25 4.17e-02 6.51 0.75 1.00e+00 1.00e+00
2TUBB2A, TUBB2B
 82
chr20q13 6.68e-01 1.31 0.15 1.00e+00 1.00e+00
2GNAS, PPDPF
 400
chr11q13 6.78e-01 1.24 0.15 1.00e+00 1.00e+00
2PHOX2A, PGM2L1
 421
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1DLC1
 45
chr15q14 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1MEIS2
 56
chr3q23 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1RBP1
 56
chr12q12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1CNTN1
 58
chr1q43 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1ACTN2
 60
chr7q35 2.28e-01 3.99 0.10 1.00e+00 1.00e+00
1CNTNAP2
 65
chr5q11 2.87e-01 3.04 0.07 1.00e+00 1.00e+00
1RAB3C
 85
chr15q13 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1SCG5
 87
chr8p11 3.15e-01 2.71 0.07 1.00e+00 1.00e+00
1SFRP1
 95
chr2p22 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1QPCT
 98
chr20p12 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1CHGB
 104
chr6q23 3.44e-01 2.43 0.06 1.00e+00 1.00e+00
1MAP7
 106
chr2p25 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1YWHAQ
 117
chr6q22 3.77e-01 2.16 0.05 1.00e+00 1.00e+00
1NCOA7
 119

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
E4BP4_01 1.73e-03 6.37 1.95 1.00e+00 1.00e+00
5TUBA1A, FAIM2, CALM2, PIK3R1, RAB3C
 223
CREBP1_Q2 3.33e-03 5.45 1.67 1.00e+00 1.00e+00
5GNAS, TH, CALM2, CHGB, MAP1LC3A
 260
CREB_01 3.79e-03 5.28 1.62 1.00e+00 1.00e+00
5TH, CALM2, TUBB2B, CHGB, MAP1LC3A
 268
ATF_B 6.59e-03 5.81 1.50 1.00e+00 1.00e+00
4TH, CALM2, CHGB, MAP1LC3A
 191
ZNF418_TARGET_GENES 1.26e-02 12.69 1.45 1.00e+00 1.00e+00
2NCOA7, ANXA2
 43
CATTGTYY_SOX9_B1 1.35e-02 3.83 1.18 1.00e+00 1.00e+00
5TUBA1A, DLC1, SFRP1, TUBB2B, YWHAQ
 368
CEBPDELTA_Q6 1.56e-02 4.47 1.16 1.00e+00 1.00e+00
4GPR22, PIK3R1, CNTNAP2, DCTN2
 247
TGACATY_UNKNOWN 1.30e-02 3.04 1.15 1.00e+00 1.00e+00
7GPR22, MAP7, FAIM2, CALM2, PIK3R1, QPCT, MEIS2
 676
ZNF423_TARGET_GENES 1.43e-02 2.60 1.11 1.00e+00 1.00e+00
9NRCAM, DLC1, RBP1, TPM1, PIK3R1, CNTNAP2, QPCT, YWHAQ, DST
 1064
STAT6_02 1.84e-02 4.25 1.10 1.00e+00 1.00e+00
4DLC1, PGM2L1, DCTN2, MEIS2
 260
TGAYRTCA_ATF3_Q6 1.75e-02 3.14 1.09 1.00e+00 1.00e+00
6GPR22, TH, FAIM2, CHGB, QPCT, MAP1LC3A
 549
GCM2_TARGET_GENES 2.02e-02 2.23 1.09 1.00e+00 1.00e+00
13NCOA7, PCBD1, SCG5, MXRA7, TLN2, CALM2, TPM1, PIK3R1, RAB3C, NACA, PGM2L1, MEIS2, DST
 1980
HMGB2_TARGET_GENES 1.86e-02 3.52 1.08 1.00e+00 1.00e+00
5DLC1, NCOA7, ANXA2, TPM1, COX7A2L
 400
PAX2_02 1.96e-02 4.16 1.08 1.00e+00 1.00e+00
4SLCO3A1, CALM2, MEIS2, PPDPF
 265
MYOD_01 2.05e-02 4.10 1.06 1.00e+00 1.00e+00
4GNAS, CALY, ALCAM, DST
 269
CREB_Q2 2.05e-02 4.10 1.06 1.00e+00 1.00e+00
4GNAS, CALM2, CHGB, MAP1LC3A
 269
SEF1_C 2.37e-02 50.83 1.06 1.00e+00 1.00e+00
1MEIS2
 6
CREB_Q4 2.13e-02 4.06 1.05 1.00e+00 1.00e+00
4GNAS, TUBB2B, CHGB, MAP1LC3A
 272
FOXH1_TARGET_GENES 1.95e-02 2.60 1.05 1.00e+00 1.00e+00
8GNAS, DLC1, ANXA2, RAB3C, CNTNAP2, SHC1, MEIS2, DST
 924
HOXA10_TARGET_GENES 2.15e-02 4.04 1.05 1.00e+00 1.00e+00
4ANXA2, TUBB2B, NACA, COX7A2L
 273

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_NOREPINEPHRINE_BIOSYNTHETIC_PROCESS 3.22e-04 103.49 9.64 3.01e-01 1.00e+00
2TH, DBH
 7
GOBP_POSITIVE_REGULATION_OF_VESICLE_FUSION 6.85e-04 64.86 6.55 3.58e-01 1.00e+00
2ANXA2, SYT1
 10
GOBP_NEURONAL_ION_CHANNEL_CLUSTERING 8.35e-04 57.69 5.91 3.58e-01 1.00e+00
2NRCAM, CNTNAP2
 11
GOBP_DETECTION_OF_CALCIUM_ION 1.18e-03 47.19 4.96 4.20e-01 1.00e+00
2CALM2, SYT1
 13
GOBP_NOREPINEPHRINE_METABOLIC_PROCESS 1.18e-03 47.19 4.96 4.20e-01 1.00e+00
2TH, DBH
 13
GOBP_CELL_SUBSTRATE_JUNCTION_ORGANIZATION 5.89e-05 13.75 4.17 2.10e-01 4.40e-01
5DLC1, SFRP1, PIK3R1, ACTN2, DST
 106
GOBP_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS 2.28e-03 32.49 3.53 6.23e-01 1.00e+00
2TH, DBH
 18
GOBP_MIDBRAIN_DEVELOPMENT 3.63e-04 13.24 3.39 3.02e-01 1.00e+00
4PHOX2A, CALM2, SFRP1, YWHAQ
 86
GOBP_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 2.81e-03 28.89 3.17 6.79e-01 1.00e+00
2TH, DBH
 20
GOBP_OSTEOCLAST_DIFFERENTIATION 4.68e-04 12.34 3.16 3.20e-01 1.00e+00
4GNAS, ANXA2, SFRP1, PIK3R1
 92
GOBP_RETROGRADE_AXONAL_TRANSPORT 3.10e-03 27.37 3.01 7.03e-01 1.00e+00
2CALY, DST
 21
GOBP_REGULATION_OF_ACTOMYOSIN_STRUCTURE_ORGANIZATION 5.94e-04 11.56 2.96 3.58e-01 1.00e+00
4DLC1, SFRP1, TPM1, PIK3R1
 98
GOBP_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY 6.90e-04 11.09 2.84 3.58e-01 1.00e+00
4DLC1, SFRP1, TPM1, PIK3R1
 102
GOBP_STRESS_FIBER_ASSEMBLY 7.42e-04 10.86 2.79 3.58e-01 1.00e+00
4DLC1, SFRP1, TPM1, PIK3R1
 104
GOBP_NEURAL_NUCLEUS_DEVELOPMENT 1.71e-03 13.99 2.71 5.34e-01 1.00e+00
3PHOX2A, CALM2, YWHAQ
 60
GOBP_REGULATION_OF_VESICLE_FUSION 4.05e-03 23.65 2.62 8.30e-01 1.00e+00
2ANXA2, SYT1
 24
GOBP_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION 1.97e-03 13.28 2.58 5.89e-01 1.00e+00
3GNAS, SFRP1, PIK3R1
 63
GOBP_REGULATION_OF_CELL_SUBSTRATE_JUNCTION_ORGANIZATION 2.55e-03 12.08 2.35 6.43e-01 1.00e+00
3DLC1, SFRP1, PIK3R1
 69
GOBP_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION 5.10e-03 20.80 2.32 8.88e-01 1.00e+00
2SFRP1, PIK3R1
 27
GOBP_CELL_JUNCTION_ASSEMBLY 1.99e-04 5.71 2.30 2.68e-01 1.00e+00
8NRCAM, DLC1, CD9, TLN2, SFRP1, ACTN2, PCLO, DST
 425

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_24H_UP 1.24e-04 8.78 3.02 3.01e-01 6.03e-01
6SCG5, ANXA2, RBP1, SFRP1, ALCAM, MAP1LC3A
 200
GSE42021_CD24HI_VS_CD24INT_TREG_THYMUS_UP 1.24e-04 8.78 3.02 3.01e-01 6.03e-01
6CNTN1, TUBA1A, NRCAM, MXRA7, ALCAM, COX7A2L
 200
GSE9650_EFFECTOR_VS_MEMORY_CD8_TCELL_UP 1.06e-03 7.16 2.19 5.84e-01 1.00e+00
5GNAS, ANXA2, CD9, ALCAM, SRP14
 199
GSE6674_ANTI_IGM_VS_ANTI_IGM_AND_CPG_STIM_BCELL_UP 1.06e-03 7.16 2.19 5.84e-01 1.00e+00
5TUBA1A, TUBB2A, CD9, TUBB2B, PGM2L1
 199
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_DP_THYMOCYTES_UP 1.06e-03 7.16 2.19 5.84e-01 1.00e+00
5TUBB2A, NCOA7, ANXA2, SYT1, PGM2L1
 199
GOLDRATH_NAIVE_VS_MEMORY_CD8_TCELL_UP 1.08e-03 7.12 2.18 5.84e-01 1.00e+00
5RAMP1, TUBA1A, MAP7, ACTN2, PPDPF
 200
GSE15930_STIM_VS_STIM_AND_IFNAB_48H_CD8_T_CELL_UP 1.08e-03 7.12 2.18 5.84e-01 1.00e+00
5CD9, PIK3R1, PCLO, COX7A2L, PPDPF
 200
GSE29164_CD8_TCELL_VS_CD8_TCELL_AND_IL12_TREATED_MELANOMA_DAY3_DN 1.08e-03 7.12 2.18 5.84e-01 1.00e+00
5TUBA1A, TUBB2A, SCG5, MAP7, CD9
 200
GSE33424_CD161_HIGH_VS_INT_CD8_TCELL_DN 1.08e-03 7.12 2.18 5.84e-01 1.00e+00
5RAMP1, TUBA1A, ANXA2, CD9, ACTN2
 200
GSE40274_CTRL_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP 2.26e-03 7.93 2.05 7.66e-01 1.00e+00
4RAMP1, ANXA2, TUBB2B, ALCAM
 141
GSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP 3.96e-03 6.75 1.74 7.66e-01 1.00e+00
4TUBB2A, NCOA7, ANXA2, TUBB2B
 165
GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP 5.16e-03 6.25 1.62 7.66e-01 1.00e+00
4ANXA2, SLCO3A1, CALM2, ALCAM
 178
GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_48H_ACT_CD4_TCELL_DN 7.20e-03 5.66 1.47 7.66e-01 1.00e+00
4ANXA2, RBP1, ALCAM, MAP1LC3A
 196
GSE22886_IL2_VS_IL15_STIM_NKCELL_UP 7.20e-03 5.66 1.47 7.66e-01 1.00e+00
4SCG5, TLN2, SFRP1, CHGB
 196
GSE360_L_MAJOR_VS_M_TUBERCULOSIS_MAC_UP 7.20e-03 5.66 1.47 7.66e-01 1.00e+00
4TH, TLN2, DBH, SHC1
 196
GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP 7.32e-03 5.63 1.46 7.66e-01 1.00e+00
4GPR22, PCBD1, MAP7, ALCAM
 197
GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_DN 7.32e-03 5.63 1.46 7.66e-01 1.00e+00
4NRCAM, ANXA2, DCTN2, DST
 197
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_8H_DN 7.32e-03 5.63 1.46 7.66e-01 1.00e+00
4SYT1, PCLO, MEIS2, DST
 197
GSE3982_MAST_CELL_VS_TH2_UP 7.45e-03 5.60 1.45 7.66e-01 1.00e+00
4TUBB2A, FAIM2, TPM1, MEIS2
 198
GSE3982_MAC_VS_TH1_UP 7.45e-03 5.60 1.45 7.66e-01 1.00e+00
4TUBA1A, TUBB2A, SCG5, TLN2
 198

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
PHOX2A 10 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NCOA7 11 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-activator; included only because TF-cat documents this
PCBD1 12 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (UniProt: P61457)
EID1 24 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MEIS2 47 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CREB5 53 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TSHZ2 58 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Also contains an atypical homodomain (Uniprot) not identified by Pfam.
NTRK1 76 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Membrane bound receptor protein
HOXC9 81 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
EPAS1 101 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
BAZ2B 103 Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif Has a putative AT-hook None
NFATC4 118 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HAND2 125 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TFAP2B 128 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FOXO3 155 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CLU 159 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of NF-kappaB transcription factor activity, but there is no DBD and no evidence of DNA binding.
COMMD1 163 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZC3H13 180 No ssDNA/RNA binding Not a DNA binding protein No motif None None
SSB 184 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PMID: 3192525; PMID: 2470590]
MAML3 188 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T175_CGCATAAGTCTGTGCG-1 Neurons:adrenal_medulla_cell_line 0.19 613.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_2lox-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, Embryonic_stem_cells: 0.26
T175_CGATCGGGTTGCGGCT-1 Neurons:adrenal_medulla_cell_line 0.15 597.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_2lox-21: 0.25
T175_CTTCCTTTCAGTGTCA-1 Neurons:adrenal_medulla_cell_line 0.19 529.49
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.28
T175_AGGGCTCTCAAGCCCG-1 Neurons:adrenal_medulla_cell_line 0.15 499.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_2lox-5: 0.25, iPS_cells:PDB_2lox-21: 0.25
T175_ACCTGAATCCAGCTCT-1 Neurons:adrenal_medulla_cell_line 0.17 488.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.27, Embryonic_stem_cells: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_2lox-22: 0.27
T188_ACAGCCGAGGGAGGAC-1 Neurons:adrenal_medulla_cell_line 0.17 480.00
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_2lox-21: 0.28
T175_TGTCAGAAGGACAGCT-1 Neurons:adrenal_medulla_cell_line 0.19 471.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:PDB_2lox-17: 0.27
T175_GGCAGTCTCGTTACCC-1 Neurons:adrenal_medulla_cell_line 0.17 471.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_2lox-17: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-5: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-21: 0.26
T175_AAACGAAGTCGCTGCA-1 Neurons:adrenal_medulla_cell_line 0.15 470.27
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_2lox-21: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, Embryonic_stem_cells: 0.24
T175_GTATTTCGTCAGTTTG-1 Neurons:adrenal_medulla_cell_line 0.16 461.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27
T175_TGCATCCTCATTGCTT-1 Neurons:adrenal_medulla_cell_line 0.18 450.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-21: 0.26, Embryonic_stem_cells: 0.26
T188_GTCCACTGTCCAGCGT-1 Neurons:adrenal_medulla_cell_line 0.17 430.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-17: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26
T175_TCACGGGAGATGTTGA-1 Neurons:adrenal_medulla_cell_line 0.17 417.53
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-21: 0.26
T175_ATATCCTAGTACAACA-1 Neurons:adrenal_medulla_cell_line 0.18 415.53
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_2lox-21: 0.25
T175_CTGTAGATCCTGCTAC-1 Neurons:adrenal_medulla_cell_line 0.16 414.60
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_2lox-21: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_2lox-17: 0.24
T175_TCCATCGCAACGACAG-1 Neurons:adrenal_medulla_cell_line 0.18 414.11
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_2lox-22: 0.23
T175_ATTTCACGTCACTCGG-1 Neurons:adrenal_medulla_cell_line 0.17 411.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_2lox-17: 0.26
T188_GACTTCCCAAAGGCGT-1 Neurons:adrenal_medulla_cell_line 0.18 407.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25
T175_CTCTCGACACGACGCT-1 Neurons:adrenal_medulla_cell_line 0.16 404.99
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-22: 0.25
T175_AGATGCTCATCACGGC-1 Neurons:adrenal_medulla_cell_line 0.16 403.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-5: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25
T175_AGGTTACCACATTACG-1 Neurons:adrenal_medulla_cell_line 0.17 403.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_2lox-21: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_2lox-5: 0.24, iPS_cells:PDB_2lox-17: 0.24
T175_GTCATCCGTAGGACCA-1 Neurons:adrenal_medulla_cell_line 0.16 400.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-21: 0.25, iPS_cells:PDB_2lox-17: 0.25
T175_AGATCCACAGACATCT-1 Neurons:adrenal_medulla_cell_line 0.18 398.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24
T175_AAACGAATCTGATGGT-1 Neurons:adrenal_medulla_cell_line 0.18 395.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28
T175_ACTATCTGTTTGCCGG-1 Neurons:adrenal_medulla_cell_line 0.17 392.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-21: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25
T175_CTCCTTTTCCACTTTA-1 Neurons:adrenal_medulla_cell_line 0.16 390.11
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22
T175_AGACAAAGTCTCTCCA-1 Neurons:adrenal_medulla_cell_line 0.17 384.16
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, Embryonic_stem_cells: 0.23
T175_TGAATGCCAAATACGA-1 Neurons:adrenal_medulla_cell_line 0.17 381.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_2lox-17: 0.26, iPS_cells:PDB_2lox-21: 0.25
T175_GTGAGTTAGCAACAGC-1 Neurons:adrenal_medulla_cell_line 0.16 379.91
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24
T175_AAATGGAGTCTAACTG-1 Neurons:adrenal_medulla_cell_line 0.15 378.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_2lox-17: 0.24
T175_TGGTACACAAGCGATG-1 Neurons:adrenal_medulla_cell_line 0.18 374.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_2lox-5: 0.25, iPS_cells:PDB_2lox-22: 0.25
T175_TTCACGCCAAGCACAG-1 Neurons:adrenal_medulla_cell_line 0.19 374.16
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_2lox-22: 0.23
T175_CAGCCAGTCGAATGCT-1 Neurons:adrenal_medulla_cell_line 0.17 373.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_2lox-22: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24
T188_TGTGCGGTCGTAATGC-1 Neurons:adrenal_medulla_cell_line 0.19 369.51
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.28, Embryonic_stem_cells: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.28, iPS_cells:PDB_2lox-22: 0.28
T175_TGACTCCAGGCTAGCA-1 Neurons:adrenal_medulla_cell_line 0.16 367.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.22
T175_GGATCTAAGCTAAATG-1 Neurons:adrenal_medulla_cell_line 0.16 364.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23
T175_TCTCAGCCAACCACGC-1 Neurons:adrenal_medulla_cell_line 0.18 362.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-22: 0.26
T175_CCTTTGGTCTCGCGTT-1 Neurons:adrenal_medulla_cell_line 0.18 362.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_2lox-17: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_2lox-21: 0.27, iPS_cells:PDB_2lox-5: 0.27
T175_TCGACGGTCCTGTAAG-1 Neurons:adrenal_medulla_cell_line 0.18 360.30
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.26, Embryonic_stem_cells: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25
T175_ATGCCTCAGCGTGAGT-1 Neurons:adrenal_medulla_cell_line 0.17 357.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-17: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-5: 0.26, iPS_cells:PDB_2lox-21: 0.26
T188_GTGTCCTTCTCAAAGC-1 Neurons:adrenal_medulla_cell_line 0.22 356.90
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.31, Embryonic_stem_cells: 0.31
T188_CCTATCGAGACCACGA-1 Neurons:adrenal_medulla_cell_line 0.17 355.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26
T175_TGCGATACACTCTAGA-1 Neurons:adrenal_medulla_cell_line 0.17 355.48
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_2lox-5: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:PDB_2lox-22: 0.25
T175_TGCACGGCACCGGAAA-1 Neurons:adrenal_medulla_cell_line 0.16 349.27
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_2lox-21: 0.22, iPS_cells:PDB_2lox-17: 0.22, iPS_cells:PDB_2lox-5: 0.22
T175_CGTTAGAGTTGCGTAT-1 Neurons:adrenal_medulla_cell_line 0.16 345.62
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_2lox-17: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_2lox-5: 0.24
T175_CATGAGTCAAAGCGTG-1 Neurons:adrenal_medulla_cell_line 0.16 344.62
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_2lox-17: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-21: 0.26, iPS_cells:PDB_2lox-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26
T175_TCGAACAGTGACACGA-1 Neurons:adrenal_medulla_cell_line 0.16 343.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.23, Tissue_stem_cells:CD326-CD56+: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_2lox-22: 0.23, Embryonic_stem_cells: 0.23
T175_TACGTCCCAAACTCTG-1 Neurons:adrenal_medulla_cell_line 0.16 342.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_2lox-5: 0.24, iPS_cells:PDB_2lox-17: 0.24
T175_CATCAAGTCCAGCCTT-1 Neurons:adrenal_medulla_cell_line 0.19 340.95
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, Embryonic_stem_cells: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26
T175_CACTAAGTCCTATTGT-1 Neurons:adrenal_medulla_cell_line 0.17 339.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_2lox-22: 0.23


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.91e-10
Mean rank of genes in gene set: 667.62
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PHOX2A 0.0076245 10 GTEx DepMap Descartes 12.20 1718.71
TH 0.0072462 17 GTEx DepMap Descartes 4.46 601.30
DBH 0.0065700 26 GTEx DepMap Descartes 7.82 731.29
CHGB 0.0062484 35 GTEx DepMap Descartes 8.49 870.17
DDC 0.0046991 83 GTEx DepMap Descartes 1.86 233.46
CYB561 0.0043620 106 GTEx DepMap Descartes 1.55 120.35
HAND2 0.0041823 125 GTEx DepMap Descartes 4.74 437.48
UCHL1 0.0035123 186 GTEx DepMap Descartes 9.31 1392.46
MAP1B 0.0024546 441 GTEx DepMap Descartes 10.93 218.10
NNAT 0.0022555 527 GTEx DepMap Descartes 3.52 665.47
SLC18A1 0.0022137 549 GTEx DepMap Descartes 0.31 23.02
EML5 0.0022056 551 GTEx DepMap Descartes 0.76 19.87
GATA3 0.0019327 704 GTEx DepMap Descartes 4.54 362.64
PCSK1N 0.0019026 718 GTEx DepMap Descartes 7.34 1710.88
DISP2 0.0014183 1171 GTEx DepMap Descartes 0.28 5.07
CHGA 0.0000698 5433 GTEx DepMap Descartes 2.65 298.93


Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.20e-07
Mean rank of genes in gene set: 942.55
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TH 0.0072462 17 GTEx DepMap Descartes 4.46 601.30
DBH 0.0065700 26 GTEx DepMap Descartes 7.82 731.29
STMN2 0.0045520 94 GTEx DepMap Descartes 37.09 4473.11
RGS5 0.0042804 114 GTEx DepMap Descartes 11.43 484.88
UCHL1 0.0035123 186 GTEx DepMap Descartes 9.31 1392.46
MAP1B 0.0024546 441 GTEx DepMap Descartes 10.93 218.10
ISL1 0.0015563 1028 GTEx DepMap Descartes 3.03 308.26
RTN1 0.0013580 1259 GTEx DepMap Descartes 7.59 535.82
ELAVL4 0.0012199 1449 GTEx DepMap Descartes 5.50 307.84
MLLT11 0.0006229 2750 GTEx DepMap Descartes 6.53 609.38
NRG1 0.0005479 3004 GTEx DepMap Descartes 0.17 3.20


N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.97e-06
Mean rank of genes in gene set: 2311.69
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GNAS 0.0103189 2 GTEx DepMap Descartes 49.03 3002.14
SCG5 0.0075272 13 GTEx DepMap Descartes 5.09 1013.54
SLCO3A1 0.0068498 22 GTEx DepMap Descartes 1.78 90.01
PCLO 0.0057542 46 GTEx DepMap Descartes 1.50 18.87
SCG3 0.0046194 90 GTEx DepMap Descartes 3.06 241.58
C1QL1 0.0033030 228 GTEx DepMap Descartes 2.26 358.74
SNAP25 0.0029308 288 GTEx DepMap Descartes 1.56 164.93
PTPRN 0.0029239 290 GTEx DepMap Descartes 0.81 39.30
NAP1L5 0.0018731 738 GTEx DepMap Descartes 0.64 81.10
PPFIA2 0.0014503 1127 GTEx DepMap Descartes 0.19 8.38
CACNA2D1 0.0012603 1383 GTEx DepMap Descartes 0.48 15.36
SYN2 0.0003637 3752 GTEx DepMap Descartes 0.06 3.68
ADCYAP1R1 0.0001102 5143 GTEx DepMap Descartes 0.08 2.81
CELF4 -0.0001259 7187 GTEx DepMap Descartes 1.25 71.76
CXCL14 -0.0001293 7217 GTEx DepMap Descartes 0.00 0.19
LGR5 -0.0003784 9461 GTEx DepMap Descartes 0.00 0.14




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.05e-10
Mean rank of genes in gene set: 4973.13
Median rank of genes in gene set: 3098
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GPR22 0.0096222 3 GTEx DepMap Descartes 1.89 168.94
NRCAM 0.0082015 6 GTEx DepMap Descartes 1.63 61.85
TUBB2A 0.0080134 7 GTEx DepMap Descartes 7.94 1138.56
PHOX2A 0.0076245 10 GTEx DepMap Descartes 12.20 1718.71
NCOA7 0.0076094 11 GTEx DepMap Descartes 3.23 NA
RBP1 0.0073958 15 GTEx DepMap Descartes 7.06 952.14
TH 0.0072462 17 GTEx DepMap Descartes 4.46 601.30
DBH 0.0065700 26 GTEx DepMap Descartes 7.82 731.29
SYT1 0.0064980 27 GTEx DepMap Descartes 5.38 283.48
TUBB2B 0.0064292 30 GTEx DepMap Descartes 28.37 3487.53
PIK3R1 0.0064259 31 GTEx DepMap Descartes 3.35 125.73
CHGB 0.0062484 35 GTEx DepMap Descartes 8.49 870.17
TMOD1 0.0054229 57 GTEx DepMap Descartes 4.69 361.21
KIDINS220 0.0053509 62 GTEx DepMap Descartes 2.41 70.71
FKBP1B 0.0052853 63 GTEx DepMap Descartes 1.25 186.88
DNER 0.0049845 71 GTEx DepMap Descartes 0.87 67.04
QDPR 0.0047951 79 GTEx DepMap Descartes 2.86 470.29
DDC 0.0046991 83 GTEx DepMap Descartes 1.86 233.46
SCG3 0.0046194 90 GTEx DepMap Descartes 3.06 241.58
STMN2 0.0045520 94 GTEx DepMap Descartes 37.09 4473.11
TMOD2 0.0044894 98 GTEx DepMap Descartes 1.19 32.65
KIF1A 0.0044280 100 GTEx DepMap Descartes 1.87 49.74
ENO2 0.0043306 109 GTEx DepMap Descartes 2.56 214.16
KIF5C 0.0042921 113 GTEx DepMap Descartes 4.23 148.71
RGS5 0.0042804 114 GTEx DepMap Descartes 11.43 484.88
NCS1 0.0041558 127 GTEx DepMap Descartes 1.02 46.59
TFAP2B 0.0041272 128 GTEx DepMap Descartes 1.86 83.13
NELFCD 0.0040454 138 GTEx DepMap Descartes 1.86 NA
FOXO3 0.0037683 155 GTEx DepMap Descartes 2.10 71.83
MAP6 0.0036582 166 GTEx DepMap Descartes 1.12 63.23


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 7924
Median rank of genes in gene set: 9209
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DLC1 0.0079274 8 GTEx DepMap Descartes 2.96 105.20
ANXA2 0.0074507 14 GTEx DepMap Descartes 6.60 461.79
TPM1 0.0064546 29 GTEx DepMap Descartes 3.27 214.54
SHC1 0.0058792 41 GTEx DepMap Descartes 1.45 104.65
TMEFF2 0.0050524 68 GTEx DepMap Descartes 1.15 83.11
SERPINE2 0.0049118 74 GTEx DepMap Descartes 2.51 109.46
FAM114A1 0.0034944 189 GTEx DepMap Descartes 0.24 14.90
NRP1 0.0034355 198 GTEx DepMap Descartes 0.88 37.46
NES 0.0031567 244 GTEx DepMap Descartes 0.94 44.01
CD44 0.0031046 253 GTEx DepMap Descartes 2.35 105.92
GNAI1 0.0029597 279 GTEx DepMap Descartes 0.73 17.43
ITM2C 0.0028772 300 GTEx DepMap Descartes 1.54 202.85
ATP1B1 0.0026667 359 GTEx DepMap Descartes 2.35 217.36
LEPROT 0.0025126 416 GTEx DepMap Descartes 0.83 45.53
ITGAV 0.0024375 449 GTEx DepMap Descartes 0.36 12.37
PPIB 0.0021201 605 GTEx DepMap Descartes 4.28 847.92
RHOC 0.0021032 619 GTEx DepMap Descartes 0.67 75.80
PDIA3 0.0020370 642 GTEx DepMap Descartes 1.87 123.62
ROBO1 0.0019923 676 GTEx DepMap Descartes 0.36 11.11
CD63 0.0018851 733 GTEx DepMap Descartes 4.89 988.68
TGFB1I1 0.0018603 747 GTEx DepMap Descartes 0.38 19.78
SCPEP1 0.0018463 761 GTEx DepMap Descartes 0.58 77.14
LAPTM4A 0.0018010 800 GTEx DepMap Descartes 1.97 354.94
LIFR 0.0017704 829 GTEx DepMap Descartes 0.22 5.09
STAT3 0.0017668 832 GTEx DepMap Descartes 1.39 70.78
RBMS1 0.0017176 873 GTEx DepMap Descartes 1.28 70.15
SSBP4 0.0015807 1004 GTEx DepMap Descartes 1.15 160.46
FAM43A 0.0015456 1037 GTEx DepMap Descartes 0.22 19.23
SLC35F5 0.0015103 1064 GTEx DepMap Descartes 0.20 5.35
DKK3 0.0015070 1066 GTEx DepMap Descartes 0.37 9.43


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.12e-02
Mean rank of genes in gene set: 5289.97
Median rank of genes in gene set: 4900
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DNER 0.0049845 71 GTEx DepMap Descartes 0.87 67.04
CLU 0.0037146 159 GTEx DepMap Descartes 2.73 247.05
GSTA4 0.0021612 582 GTEx DepMap Descartes 1.19 169.05
IGF1R 0.0016279 949 GTEx DepMap Descartes 0.47 9.52
TM7SF2 0.0014950 1078 GTEx DepMap Descartes 0.62 65.80
PAPSS2 0.0014093 1185 GTEx DepMap Descartes 0.08 4.80
JAKMIP2 0.0012861 1358 GTEx DepMap Descartes 0.49 12.98
PDE10A 0.0009809 1855 GTEx DepMap Descartes 0.15 4.55
FDPS 0.0009694 1882 GTEx DepMap Descartes 1.25 145.49
MSMO1 0.0009673 1894 GTEx DepMap Descartes 0.37 39.00
SH3PXD2B 0.0009608 1908 GTEx DepMap Descartes 0.09 2.85
SH3BP5 0.0009199 1995 GTEx DepMap Descartes 0.58 42.80
HMGCS1 0.0007668 2337 GTEx DepMap Descartes 0.36 15.90
INHA 0.0005940 2848 GTEx DepMap Descartes 0.02 3.68
HMGCR 0.0005518 2984 GTEx DepMap Descartes 0.32 16.60
GRAMD1B 0.0003239 3913 GTEx DepMap Descartes 0.06 1.82
NPC1 0.0002938 4049 GTEx DepMap Descartes 0.07 3.83
DHCR7 0.0001819 4654 GTEx DepMap Descartes 0.13 10.53
FRMD5 0.0001100 5146 GTEx DepMap Descartes 0.08 3.75
POR 0.0000886 5294 GTEx DepMap Descartes 0.23 22.28
DHCR24 0.0000348 5662 GTEx DepMap Descartes 0.11 4.13
SCAP -0.0000311 6188 GTEx DepMap Descartes 0.20 11.38
STAR -0.0000832 6712 GTEx DepMap Descartes 0.01 0.73
LDLR -0.0000992 6893 GTEx DepMap Descartes 0.07 2.84
FREM2 -0.0001081 6999 GTEx DepMap Descartes 0.00 0.00
SCARB1 -0.0002724 8597 GTEx DepMap Descartes 0.07 2.60
SLC16A9 -0.0003130 8947 GTEx DepMap Descartes 0.07 4.03
BAIAP2L1 -0.0003666 9360 GTEx DepMap Descartes 0.00 0.02
CYB5B -0.0003937 9571 GTEx DepMap Descartes 0.33 17.31
SGCZ -0.0004248 9830 GTEx DepMap Descartes 0.00 0.02


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.85e-09
Mean rank of genes in gene set: 3068.22
Median rank of genes in gene set: 872
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TUBA1A 0.0087402 5 GTEx DepMap Descartes 56.03 7014.33
TUBB2A 0.0080134 7 GTEx DepMap Descartes 7.94 1138.56
TUBB2B 0.0064292 30 GTEx DepMap Descartes 28.37 3487.53
TMEFF2 0.0050524 68 GTEx DepMap Descartes 1.15 83.11
NTRK1 0.0048783 76 GTEx DepMap Descartes 2.02 165.82
STMN2 0.0045520 94 GTEx DepMap Descartes 37.09 4473.11
TMEM132C 0.0035763 175 GTEx DepMap Descartes 0.52 27.98
RBFOX1 0.0033105 224 GTEx DepMap Descartes 0.66 35.26
IL7 0.0033029 229 GTEx DepMap Descartes 1.33 167.63
GAP43 0.0032184 237 GTEx DepMap Descartes 5.57 655.60
REEP1 0.0030507 265 GTEx DepMap Descartes 0.72 43.98
GAL 0.0030103 272 GTEx DepMap Descartes 2.73 874.62
EYA4 0.0029041 295 GTEx DepMap Descartes 0.32 15.78
PLXNA4 0.0026393 368 GTEx DepMap Descartes 0.44 8.12
MAP1B 0.0024546 441 GTEx DepMap Descartes 10.93 218.10
SLC6A2 0.0022235 545 GTEx DepMap Descartes 0.52 36.78
BASP1 0.0021988 554 GTEx DepMap Descartes 11.06 1416.21
CNTFR 0.0020306 648 GTEx DepMap Descartes 1.16 144.84
KCNB2 0.0018294 772 GTEx DepMap Descartes 0.26 17.03
ANKFN1 0.0017847 816 GTEx DepMap Descartes 0.11 6.86
PTCHD1 0.0017189 872 GTEx DepMap Descartes 0.22 4.51
ISL1 0.0015563 1028 GTEx DepMap Descartes 3.03 308.26
RGMB 0.0011649 1533 GTEx DepMap Descartes 0.67 35.86
GREM1 0.0011210 1605 GTEx DepMap Descartes 0.19 3.57
MAB21L1 0.0009311 1972 GTEx DepMap Descartes 1.29 102.99
EYA1 0.0007024 2528 GTEx DepMap Descartes 0.18 11.24
MLLT11 0.0006229 2750 GTEx DepMap Descartes 6.53 609.38
RPH3A 0.0004716 3267 GTEx DepMap Descartes 0.09 4.72
CCND1 0.0003645 3748 GTEx DepMap Descartes 8.82 547.24
CNKSR2 0.0002067 4486 GTEx DepMap Descartes 0.20 5.59


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7942.39
Median rank of genes in gene set: 8572.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RAMP2 0.0006379 2699 GTEx DepMap Descartes 1.06 291.41
EFNB2 0.0005095 3130 GTEx DepMap Descartes 0.31 15.40
NOTCH4 0.0003853 3650 GTEx DepMap Descartes 0.16 5.84
HYAL2 0.0002808 4121 GTEx DepMap Descartes 0.44 26.51
MYRIP 0.0002803 4125 GTEx DepMap Descartes 0.03 1.44
EHD3 0.0002800 4127 GTEx DepMap Descartes 0.04 1.76
SHANK3 0.0002563 4232 GTEx DepMap Descartes 0.03 1.07
GALNT15 -0.0000155 6054 GTEx DepMap Descartes 0.01 NA
PTPRB -0.0001277 7203 GTEx DepMap Descartes 0.01 0.15
NR5A2 -0.0001292 7216 GTEx DepMap Descartes 0.00 0.06
BTNL9 -0.0001514 7461 GTEx DepMap Descartes 0.00 0.11
ESM1 -0.0001600 7547 GTEx DepMap Descartes 0.00 0.02
MMRN2 -0.0001614 7564 GTEx DepMap Descartes 0.01 0.41
SLCO2A1 -0.0002047 8010 GTEx DepMap Descartes 0.00 0.00
RASIP1 -0.0002130 8085 GTEx DepMap Descartes 0.01 0.58
NPR1 -0.0002133 8090 GTEx DepMap Descartes 0.00 0.00
ROBO4 -0.0002166 8110 GTEx DepMap Descartes 0.01 0.34
CRHBP -0.0002645 8527 GTEx DepMap Descartes 0.00 0.00
SHE -0.0002667 8544 GTEx DepMap Descartes 0.00 0.00
KANK3 -0.0002730 8601 GTEx DepMap Descartes 0.00 0.17
PLVAP -0.0002758 8620 GTEx DepMap Descartes 0.00 0.11
CDH5 -0.0002783 8647 GTEx DepMap Descartes 0.00 0.02
FLT4 -0.0002950 8800 GTEx DepMap Descartes 0.00 0.01
TIE1 -0.0003022 8864 GTEx DepMap Descartes 0.00 0.05
KDR -0.0003035 8872 GTEx DepMap Descartes 0.00 0.07
ARHGAP29 -0.0003456 9207 GTEx DepMap Descartes 0.14 3.82
CDH13 -0.0003529 9265 GTEx DepMap Descartes 0.02 0.40
CALCRL -0.0003544 9273 GTEx DepMap Descartes 0.00 0.04
TEK -0.0003689 9380 GTEx DepMap Descartes 0.00 0.02
PODXL -0.0003816 9486 GTEx DepMap Descartes 0.03 1.20


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8947
Median rank of genes in gene set: 9205.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ADAMTS2 0.0011478 1557 GTEx DepMap Descartes 0.11 4.10
ITGA11 0.0000433 5618 GTEx DepMap Descartes 0.01 0.11
LRRC17 0.0000425 5623 GTEx DepMap Descartes 0.02 1.61
FREM1 -0.0000064 5988 GTEx DepMap Descartes 0.01 0.14
BICC1 -0.0000790 6675 GTEx DepMap Descartes 0.02 0.97
SFRP2 -0.0001186 7105 GTEx DepMap Descartes 0.00 0.01
GAS2 -0.0001425 7361 GTEx DepMap Descartes 0.01 0.81
SCARA5 -0.0001459 7404 GTEx DepMap Descartes 0.00 0.00
ABCC9 -0.0001512 7458 GTEx DepMap Descartes 0.00 0.06
COL27A1 -0.0001577 7526 GTEx DepMap Descartes 0.00 0.04
RSPO3 -0.0001750 7728 GTEx DepMap Descartes 0.00 NA
IGFBP3 -0.0002142 8094 GTEx DepMap Descartes 0.00 0.11
POSTN -0.0002211 8150 GTEx DepMap Descartes 0.05 1.27
ADAMTSL3 -0.0002245 8180 GTEx DepMap Descartes 0.00 0.01
CCDC80 -0.0002249 8183 GTEx DepMap Descartes 0.02 0.42
DKK2 -0.0002579 8470 GTEx DepMap Descartes 0.00 0.06
LAMC3 -0.0002708 8580 GTEx DepMap Descartes 0.00 0.00
PAMR1 -0.0002849 8709 GTEx DepMap Descartes 0.00 0.11
C7 -0.0003265 9044 GTEx DepMap Descartes 0.00 0.01
OGN -0.0003423 9166 GTEx DepMap Descartes 0.00 0.00
ACTA2 -0.0003442 9188 GTEx DepMap Descartes 0.08 6.36
MGP -0.0003449 9195 GTEx DepMap Descartes 0.02 0.85
ABCA6 -0.0003467 9216 GTEx DepMap Descartes 0.00 0.03
LOX -0.0003641 9343 GTEx DepMap Descartes 0.00 0.02
ISLR -0.0003719 9405 GTEx DepMap Descartes 0.00 0.02
PRICKLE1 -0.0003731 9416 GTEx DepMap Descartes 0.15 6.18
EDNRA -0.0003744 9431 GTEx DepMap Descartes 0.00 0.05
PRRX1 -0.0003873 9520 GTEx DepMap Descartes 0.00 0.03
LUM -0.0004047 9662 GTEx DepMap Descartes 0.00 0.14
DCN -0.0004080 9681 GTEx DepMap Descartes 0.00 0.01


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.51e-06
Mean rank of genes in gene set: 3669.89
Median rank of genes in gene set: 2158
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHGB 0.0062484 35 GTEx DepMap Descartes 8.49 870.17
GALNTL6 0.0041874 123 GTEx DepMap Descartes 0.22 13.52
C1QL1 0.0033030 228 GTEx DepMap Descartes 2.26 358.74
TBX20 0.0030525 264 GTEx DepMap Descartes 0.08 12.41
UNC80 0.0028467 309 GTEx DepMap Descartes 0.45 8.50
GRID2 0.0027623 327 GTEx DepMap Descartes 0.29 13.04
FAM155A 0.0027513 332 GTEx DepMap Descartes 0.54 13.91
PACRG 0.0023009 502 GTEx DepMap Descartes 0.20 28.41
SLC18A1 0.0022137 549 GTEx DepMap Descartes 0.31 23.02
GCH1 0.0020556 634 GTEx DepMap Descartes 0.54 46.72
HTATSF1 0.0020382 641 GTEx DepMap Descartes 1.01 83.79
ROBO1 0.0019923 676 GTEx DepMap Descartes 0.36 11.11
PCSK1N 0.0019026 718 GTEx DepMap Descartes 7.34 1710.88
CDH18 0.0017240 867 GTEx DepMap Descartes 0.08 4.43
AGBL4 0.0016313 946 GTEx DepMap Descartes 0.11 7.50
EML6 0.0012736 1374 GTEx DepMap Descartes 0.09 2.09
LAMA3 0.0011103 1623 GTEx DepMap Descartes 0.04 0.98
PCSK2 0.0009197 1997 GTEx DepMap Descartes 0.06 3.79
MGAT4C 0.0008530 2113 GTEx DepMap Descartes 0.23 1.92
SPOCK3 0.0008137 2203 GTEx DepMap Descartes 0.12 9.17
DGKK 0.0008069 2218 GTEx DepMap Descartes 0.08 2.82
NTNG1 0.0006377 2700 GTEx DepMap Descartes 0.16 7.79
CCSER1 0.0005538 2976 GTEx DepMap Descartes 0.07 NA
CNTN3 0.0004984 3166 GTEx DepMap Descartes 0.02 1.05
TIAM1 0.0004024 3574 GTEx DepMap Descartes 0.18 6.36
FGF14 0.0000746 5396 GTEx DepMap Descartes 0.15 3.00
CHGA 0.0000698 5433 GTEx DepMap Descartes 2.65 298.93
SLC24A2 0.0000393 5641 GTEx DepMap Descartes 0.01 0.30
PENK -0.0000874 6757 GTEx DepMap Descartes 0.00 0.00
TENM1 -0.0000890 6783 GTEx DepMap Descartes 0.04 NA


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.40e-01
Mean rank of genes in gene set: 5998.1
Median rank of genes in gene set: 7108
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SOX6 0.0029902 275 GTEx DepMap Descartes 0.26 7.75
TSPAN5 0.0016423 936 GTEx DepMap Descartes 0.84 50.37
SPTB 0.0015903 987 GTEx DepMap Descartes 0.13 3.39
TRAK2 0.0012484 1398 GTEx DepMap Descartes 0.18 7.04
EPB41 0.0011663 1525 GTEx DepMap Descartes 0.63 23.90
DENND4A 0.0010972 1638 GTEx DepMap Descartes 0.30 9.10
SNCA 0.0008162 2195 GTEx DepMap Descartes 0.50 35.75
FECH 0.0007471 2399 GTEx DepMap Descartes 0.17 5.32
RAPGEF2 0.0006876 2560 GTEx DepMap Descartes 0.28 8.55
ANK1 0.0005843 2876 GTEx DepMap Descartes 0.11 2.98
SLC25A37 0.0005697 2922 GTEx DepMap Descartes 0.44 22.57
TMCC2 0.0000634 5479 GTEx DepMap Descartes 0.05 3.12
RHD -0.0000160 6058 GTEx DepMap Descartes 0.00 0.04
SLC25A21 -0.0000735 6613 GTEx DepMap Descartes 0.00 0.00
XPO7 -0.0001188 7108 GTEx DepMap Descartes 0.16 7.69
SLC4A1 -0.0001397 7327 GTEx DepMap Descartes 0.00 0.05
MARCH3 -0.0001418 7354 GTEx DepMap Descartes 0.04 NA
RGS6 -0.0001456 7400 GTEx DepMap Descartes 0.00 0.01
ABCB10 -0.0001698 7660 GTEx DepMap Descartes 0.05 3.19
ALAS2 -0.0001818 7811 GTEx DepMap Descartes 0.00 0.09
CPOX -0.0002068 8026 GTEx DepMap Descartes 0.04 3.31
SELENBP1 -0.0003004 8846 GTEx DepMap Descartes 0.00 0.10
MICAL2 -0.0003349 9126 GTEx DepMap Descartes 0.01 0.45
GCLC -0.0004454 9958 GTEx DepMap Descartes 0.06 3.75
SPECC1 -0.0004783 10155 GTEx DepMap Descartes 0.04 1.21
CAT -0.0004855 10207 GTEx DepMap Descartes 0.15 16.49
TFR2 -0.0006371 10953 GTEx DepMap Descartes 0.05 3.23
BLVRB -0.0008967 11680 GTEx DepMap Descartes 0.08 9.69
GYPC -0.0017806 12473 GTEx DepMap Descartes 0.06 5.73
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10352.13
Median rank of genes in gene set: 11449.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD163L1 0.0042336 119 GTEx DepMap Descartes 0.82 45.66
HRH1 0.0008580 2100 GTEx DepMap Descartes 0.05 2.71
RBPJ 0.0006042 2817 GTEx DepMap Descartes 0.99 40.18
WWP1 0.0000264 5729 GTEx DepMap Descartes 0.10 5.21
IFNGR1 -0.0000741 6619 GTEx DepMap Descartes 0.31 29.85
ATP8B4 -0.0004466 9968 GTEx DepMap Descartes 0.00 0.03
FGD2 -0.0004559 10022 GTEx DepMap Descartes 0.00 0.09
RGL1 -0.0005934 10771 GTEx DepMap Descartes 0.01 0.58
MERTK -0.0005982 10788 GTEx DepMap Descartes 0.00 0.11
SFMBT2 -0.0006116 10841 GTEx DepMap Descartes 0.01 0.39
SLC9A9 -0.0006246 10896 GTEx DepMap Descartes 0.01 0.30
SPP1 -0.0006275 10916 GTEx DepMap Descartes 0.07 4.26
CPVL -0.0006381 10958 GTEx DepMap Descartes 0.04 1.90
HCK -0.0006984 11172 GTEx DepMap Descartes 0.01 0.51
CD163 -0.0007145 11217 GTEx DepMap Descartes 0.01 0.13
SLC1A3 -0.0007292 11258 GTEx DepMap Descartes 0.01 0.14
MSR1 -0.0007329 11267 GTEx DepMap Descartes 0.01 0.27
AXL -0.0007422 11292 GTEx DepMap Descartes 0.00 0.06
SLCO2B1 -0.0007972 11449 GTEx DepMap Descartes 0.00 0.06
CSF1R -0.0007972 11450 GTEx DepMap Descartes 0.01 0.28
MARCH1 -0.0007996 11461 GTEx DepMap Descartes 0.01 NA
MS4A4A -0.0008217 11513 GTEx DepMap Descartes 0.03 1.78
CYBB -0.0008302 11533 GTEx DepMap Descartes 0.02 0.75
CTSD -0.0008308 11534 GTEx DepMap Descartes 0.59 63.59
ADAP2 -0.0008462 11569 GTEx DepMap Descartes 0.01 0.75
ABCA1 -0.0008587 11593 GTEx DepMap Descartes 0.02 0.38
CD14 -0.0008698 11622 GTEx DepMap Descartes 0.05 4.97
CST3 -0.0008745 11633 GTEx DepMap Descartes 1.78 119.72
ITPR2 -0.0008790 11642 GTEx DepMap Descartes 0.05 0.82
LGMN -0.0009039 11697 GTEx DepMap Descartes 0.16 14.29


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.30e-01
Mean rank of genes in gene set: 6456.55
Median rank of genes in gene set: 7948
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SFRP1 0.0064956 28 GTEx DepMap Descartes 2.21 127.22
DST 0.0056610 49 GTEx DepMap Descartes 3.63 40.82
PMP22 0.0036142 168 GTEx DepMap Descartes 2.61 364.16
LRRTM4 0.0031012 255 GTEx DepMap Descartes 0.15 10.50
MARCKS 0.0028380 310 GTEx DepMap Descartes 8.60 471.82
SCN7A 0.0023999 463 GTEx DepMap Descartes 0.33 11.38
GFRA3 0.0020338 643 GTEx DepMap Descartes 0.89 114.72
EGFLAM 0.0015855 997 GTEx DepMap Descartes 0.11 6.05
LAMB1 0.0014238 1161 GTEx DepMap Descartes 0.36 15.98
LAMA4 0.0011485 1554 GTEx DepMap Descartes 0.31 10.93
PTN 0.0010714 1691 GTEx DepMap Descartes 0.89 135.59
NRXN1 0.0010640 1711 GTEx DepMap Descartes 1.04 26.90
SORCS1 0.0008636 2091 GTEx DepMap Descartes 0.16 5.52
FIGN 0.0007306 2452 GTEx DepMap Descartes 0.20 5.22
PAG1 0.0005673 2934 GTEx DepMap Descartes 0.35 7.71
XKR4 0.0000345 5664 GTEx DepMap Descartes 0.03 0.33
IL1RAPL2 -0.0000231 6115 GTEx DepMap Descartes 0.00 0.01
HMGA2 -0.0001150 7083 GTEx DepMap Descartes 0.00 0.00
PTPRZ1 -0.0001674 7633 GTEx DepMap Descartes 0.00 0.01
SOX5 -0.0001817 7810 GTEx DepMap Descartes 0.16 5.87
MDGA2 -0.0001846 7840 GTEx DepMap Descartes 0.00 0.00
TRPM3 -0.0001977 7941 GTEx DepMap Descartes 0.00 0.09
GAS7 -0.0001991 7955 GTEx DepMap Descartes 0.03 0.78
KCTD12 -0.0002446 8361 GTEx DepMap Descartes 0.10 3.77
IL1RAPL1 -0.0002522 8423 GTEx DepMap Descartes 0.00 0.03
ADAMTS5 -0.0002707 8578 GTEx DepMap Descartes 0.00 0.01
NRXN3 -0.0002824 8671 GTEx DepMap Descartes 0.01 0.18
MPZ -0.0002954 8802 GTEx DepMap Descartes 0.02 1.96
LAMC1 -0.0003267 9046 GTEx DepMap Descartes 0.03 1.02
PLCE1 -0.0003352 9128 GTEx DepMap Descartes 0.04 0.76


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8124.42
Median rank of genes in gene set: 8829
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD9 0.0070738 19 GTEx DepMap Descartes 3.35 484.22
PRKAR2B 0.0024913 425 GTEx DepMap Descartes 0.82 52.95
LIMS1 0.0014603 1118 GTEx DepMap Descartes 0.74 39.61
PDE3A 0.0012240 1443 GTEx DepMap Descartes 0.12 4.12
RAP1B 0.0012141 1458 GTEx DepMap Descartes 0.95 17.00
RAB27B 0.0006626 2618 GTEx DepMap Descartes 0.07 2.13
TUBB1 0.0005775 2897 GTEx DepMap Descartes 0.01 1.09
DOK6 0.0004657 3299 GTEx DepMap Descartes 0.17 4.09
ACTN1 0.0003037 3999 GTEx DepMap Descartes 0.58 29.38
HIPK2 0.0002331 4345 GTEx DepMap Descartes 0.41 6.20
STON2 0.0002136 4452 GTEx DepMap Descartes 0.12 6.00
VCL -0.0000942 6835 GTEx DepMap Descartes 0.12 3.35
GP1BA -0.0001070 6980 GTEx DepMap Descartes 0.00 0.14
STOM -0.0001231 7161 GTEx DepMap Descartes 0.13 9.60
ITGB3 -0.0001334 7262 GTEx DepMap Descartes 0.00 0.00
UBASH3B -0.0001766 7751 GTEx DepMap Descartes 0.03 1.03
TRPC6 -0.0001806 7800 GTEx DepMap Descartes 0.00 0.01
ITGA2B -0.0001838 7835 GTEx DepMap Descartes 0.01 1.06
MMRN1 -0.0002080 8029 GTEx DepMap Descartes 0.00 0.03
ARHGAP6 -0.0002296 8226 GTEx DepMap Descartes 0.00 0.01
P2RX1 -0.0002841 8695 GTEx DepMap Descartes 0.00 0.06
SLC24A3 -0.0002862 8723 GTEx DepMap Descartes 0.00 0.03
MED12L -0.0002991 8829 GTEx DepMap Descartes 0.03 0.52
INPP4B -0.0003340 9116 GTEx DepMap Descartes 0.06 1.43
LTBP1 -0.0003442 9186 GTEx DepMap Descartes 0.01 0.17
MYLK -0.0003550 9277 GTEx DepMap Descartes 0.02 0.37
MCTP1 -0.0004382 9904 GTEx DepMap Descartes 0.01 0.46
ANGPT1 -0.0004472 9970 GTEx DepMap Descartes 0.01 0.26
PSTPIP2 -0.0004696 10105 GTEx DepMap Descartes 0.00 0.16
THBS1 -0.0005326 10496 GTEx DepMap Descartes 0.01 0.14


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8849.38
Median rank of genes in gene set: 11233
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD44 0.0031046 253 GTEx DepMap Descartes 2.35 105.92
FYN 0.0021093 615 GTEx DepMap Descartes 1.72 114.15
RAP1GAP2 0.0017979 801 GTEx DepMap Descartes 0.44 15.65
ABLIM1 0.0012612 1382 GTEx DepMap Descartes 0.30 9.45
FOXP1 0.0012321 1429 GTEx DepMap Descartes 1.39 37.54
SCML4 0.0010914 1650 GTEx DepMap Descartes 0.18 11.32
STK39 0.0007674 2332 GTEx DepMap Descartes 0.44 31.81
CELF2 0.0005205 3098 GTEx DepMap Descartes 0.71 20.17
TMSB10 0.0005160 3108 GTEx DepMap Descartes 49.94 25197.23
NCALD 0.0003265 3898 GTEx DepMap Descartes 0.14 8.68
DOCK10 0.0002066 4488 GTEx DepMap Descartes 0.17 6.20
MSN 0.0001406 4918 GTEx DepMap Descartes 0.39 24.78
SORL1 -0.0001076 6990 GTEx DepMap Descartes 0.26 5.61
BACH2 -0.0003750 9436 GTEx DepMap Descartes 0.13 3.61
BCL2 -0.0004858 10208 GTEx DepMap Descartes 0.36 11.74
PITPNC1 -0.0005284 10473 GTEx DepMap Descartes 0.17 6.58
MCTP2 -0.0005367 10509 GTEx DepMap Descartes 0.01 0.33
ANKRD44 -0.0005404 10532 GTEx DepMap Descartes 0.13 4.45
PLEKHA2 -0.0006766 11100 GTEx DepMap Descartes 0.03 1.30
ITPKB -0.0007038 11185 GTEx DepMap Descartes 0.01 0.20
SAMD3 -0.0007186 11230 GTEx DepMap Descartes 0.01 0.32
WIPF1 -0.0007203 11236 GTEx DepMap Descartes 0.16 8.28
GNG2 -0.0007796 11389 GTEx DepMap Descartes 0.59 36.82
TOX -0.0008729 11632 GTEx DepMap Descartes 0.24 13.19
CCL5 -0.0008904 11665 GTEx DepMap Descartes 0.22 35.10
PRKCH -0.0009406 11776 GTEx DepMap Descartes 0.01 0.75
RCSD1 -0.0009511 11802 GTEx DepMap Descartes 0.03 1.01
PDE3B -0.0009711 11851 GTEx DepMap Descartes 0.09 3.39
MBNL1 -0.0009870 11885 GTEx DepMap Descartes 0.20 7.49
SKAP1 -0.0009938 11900 GTEx DepMap Descartes 0.02 2.16


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.87e-02
Mean rank of genes in gene set: 1408.5
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
INPP5J 0.0017725 828 GTEx DepMap Descartes 0.11 8.10
PANX2 0.0009224 1989 GTEx DepMap Descartes 0.18 14.97


Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.04e-02
Mean rank of genes in gene set: 1474
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRDX2 0.0029525 282 GTEx DepMap Descartes 7.15 989.16
KCNH2 0.0006500 2666 GTEx DepMap Descartes 0.28 15.60


HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (curated markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.91e-02
Mean rank of genes in gene set: 285
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GATA2 0.0029351 285 GTEx DepMap Descartes 2.55 190.19