Program: 24. Peripheral Nervous System III.

Program: 24. Peripheral Nervous System III.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 CHGA 0.0176475 chromogranin A GTEx DepMap Descartes 94.32 11651.42
2 CHGB 0.0163608 chromogranin B GTEx DepMap Descartes 49.98 4972.72
3 SCG2 0.0147153 secretogranin II GTEx DepMap Descartes 12.62 1285.25
4 RAMP1 0.0133373 receptor activity modifying protein 1 GTEx DepMap Descartes 8.76 2334.58
5 PENK 0.0132775 proenkephalin GTEx DepMap Descartes 8.46 1571.03
6 INSM1 0.0131589 INSM transcriptional repressor 1 GTEx DepMap Descartes 3.54 307.92
7 C1QL1 0.0126086 complement C1q like 1 GTEx DepMap Descartes 4.41 675.65
8 TH 0.0120792 tyrosine hydroxylase GTEx DepMap Descartes 10.05 1450.43
9 CARTPT 0.0116929 CART prepropeptide GTEx DepMap Descartes 7.50 1867.42
10 DBH 0.0113835 dopamine beta-hydroxylase GTEx DepMap Descartes 11.94 1169.41
11 HTATSF1 0.0108788 HIV-1 Tat specific factor 1 GTEx DepMap Descartes 8.81 746.65
12 SLC18A1 0.0107091 solute carrier family 18 member A1 GTEx DepMap Descartes 3.69 355.15
13 PCSK1N 0.0102016 proprotein convertase subtilisin/kexin type 1 inhibitor GTEx DepMap Descartes 14.78 3168.28
14 PNMT 0.0100336 phenylethanolamine N-methyltransferase GTEx DepMap Descartes 6.62 1387.62
15 ARC 0.0096922 activity regulated cytoskeleton associated protein GTEx DepMap Descartes 2.95 224.41
16 CYB561 0.0092274 cytochrome b561 GTEx DepMap Descartes 3.01 267.13
17 CHRNA3 0.0091114 cholinergic receptor nicotinic alpha 3 subunit GTEx DepMap Descartes 3.53 326.62
18 NT5DC2 0.0088095 5’-nucleotidase domain containing 2 GTEx DepMap Descartes 7.14 867.51
19 SLC24A2 0.0086225 solute carrier family 24 member 2 GTEx DepMap Descartes 1.25 33.30
20 VWA5B2 0.0084371 von Willebrand factor A domain containing 5B2 GTEx DepMap Descartes 0.93 61.06
21 FAM162B 0.0084005 family with sequence similarity 162 member B GTEx DepMap Descartes 2.35 508.56
22 SERTM2 0.0080740 serine rich and transmembrane domain containing 2 GTEx DepMap Descartes 0.78 NA
23 MIR7-3HG 0.0079361 MIR7-3 host gene GTEx DepMap Descartes 0.73 104.42
24 QDPR 0.0075939 quinoid dihydropteridine reductase GTEx DepMap Descartes 4.46 649.01
25 RGS4 0.0074418 regulator of G protein signaling 4 GTEx DepMap Descartes 7.25 516.11
26 SCG5 0.0073173 secretogranin V GTEx DepMap Descartes 3.46 602.98
27 ARFGEF3 0.0072925 ARFGEF family member 3 GTEx DepMap Descartes 1.13 NA
28 CNTN1 0.0072304 contactin 1 GTEx DepMap Descartes 4.43 209.12
29 PCSK2 0.0072290 proprotein convertase subtilisin/kexin type 2 GTEx DepMap Descartes 1.40 82.06
30 SLC35D3 0.0071926 solute carrier family 35 member D3 GTEx DepMap Descartes 0.38 33.13
31 ANKRD29 0.0071797 ankyrin repeat domain 29 GTEx DepMap Descartes 1.29 92.65
32 MEG3 0.0070788 maternally expressed 3 GTEx DepMap Descartes 69.04 1877.73
33 DGKK 0.0069569 diacylglycerol kinase kappa GTEx DepMap Descartes 1.07 37.75
34 SEZ6L2 0.0069160 seizure related 6 homolog like 2 GTEx DepMap Descartes 2.79 199.95
35 RGS5 0.0068912 regulator of G protein signaling 5 GTEx DepMap Descartes 15.06 667.31
36 VGF 0.0068901 VGF nerve growth factor inducible GTEx DepMap Descartes 1.57 138.81
37 CCSER1 0.0068894 coiled-coil serine rich protein 1 GTEx DepMap Descartes 1.38 NA
38 ST18 0.0068163 ST18 C2H2C-type zinc finger transcription factor GTEx DepMap Descartes 0.94 46.16
39 CNIH2 0.0067892 cornichon family AMPA receptor auxiliary protein 2 GTEx DepMap Descartes 1.07 153.57
40 DLK1 0.0065554 delta like non-canonical Notch ligand 1 GTEx DepMap Descartes 46.63 2296.78
41 CFAP61 0.0063367 cilia and flagella associated protein 61 GTEx DepMap Descartes 0.40 NA
42 NLRP1 0.0062756 NLR family pyrin domain containing 1 GTEx DepMap Descartes 2.75 110.96
43 P4HTM 0.0062610 prolyl 4-hydroxylase, transmembrane GTEx DepMap Descartes 1.86 82.01
44 C2CD4A 0.0062009 C2 calcium dependent domain containing 4A GTEx DepMap Descartes 0.50 40.26
45 SYT4 0.0061707 synaptotagmin 4 GTEx DepMap Descartes 1.21 80.02
46 ACE 0.0061431 angiotensin I converting enzyme GTEx DepMap Descartes 0.69 37.25
47 ZDBF2 0.0060973 zinc finger DBF-type containing 2 GTEx DepMap Descartes 2.43 71.71
48 HACD3 0.0060495 3-hydroxyacyl-CoA dehydratase 3 GTEx DepMap Descartes 4.92 NA
49 SLC16A12 0.0060204 solute carrier family 16 member 12 GTEx DepMap Descartes 0.60 37.58
50 UNC5A 0.0059863 unc-5 netrin receptor A GTEx DepMap Descartes 0.73 53.30


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UMAP plots showing activity of gene expression program identified in GEP 24. Peripheral Nervous System III:

Interactive UMAP Plot
Interactive Boxplot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DESCARTES_MAIN_FETAL_SYMPATHOBLASTS 3.26e-39 411.99 202.40 2.19e-36 2.19e-36
19CHGA, CHGB, SCG2, PENK, C1QL1, TH, CARTPT, DBH, HTATSF1, SLC18A1, PNMT, ARC, CYB561, NT5DC2, SERTM2, QDPR, NLRP1, ZDBF2, HACD3
 57
BUSSLINGER_GASTRIC_ANTRAL_ECS 6.08e-09 278.88 59.22 2.15e-07 4.08e-06
4SCG2, PCSK1N, SCG5, MEG3
 12
DESCARTES_FETAL_ADRENAL_SYMPATHOBLASTS 5.32e-22 97.30 46.85 1.78e-19 3.57e-19
14CHGA, PENK, CARTPT, PNMT, ARC, SLC24A2, VWA5B2, SERTM2, MIR7-3HG, PCSK2, VGF, CCSER1, ST18, C2CD4A
 117
BUSSLINGER_GASTRIC_D_CELLS 2.10e-09 124.04 35.28 9.39e-08 1.41e-06
5CHGB, PCSK1N, SCG5, ARFGEF3, PCSK2
 28
BUSSLINGER_DUODENAL_EC_CELLS 3.61e-09 109.69 31.48 1.35e-07 2.42e-06
5CHGA, CHGB, SCG2, PCSK1N, PCSK2
 31
BUSSLINGER_GASTRIC_OXYNTIC_ENTEROCHROMAFFIN_LIKE_CELLS 6.42e-14 74.19 30.66 7.18e-12 4.31e-11
9CHGA, CHGB, SCG2, PCSK1N, QDPR, SCG5, ARFGEF3, SEZ6L2, VGF
 85
DESCARTES_FETAL_HEART_VISCERAL_NEURONS 5.58e-12 62.03 24.37 4.16e-10 3.75e-09
8CHGB, SCG2, TH, DBH, SLC18A1, CHRNA3, RGS4, VGF
 87
TRAVAGLINI_LUNG_NEUROENDOCRINE_CELL 5.20e-14 54.49 23.73 6.98e-12 3.49e-11
10CHGB, SCG2, INSM1, PCSK1N, MIR7-3HG, SCG5, PCSK2, SLC35D3, MEG3, SYT4
 128
BUSSLINGER_DUODENAL_I_CELLS 3.76e-06 126.05 22.32 1.01e-04 2.52e-03
3SCG2, PCSK1N, SCG5
 16
DESCARTES_FETAL_LUNG_NEUROENDOCRINE_CELLS 3.94e-10 51.05 18.83 2.03e-08 2.64e-07
7CHGA, INSM1, SLC18A1, VWA5B2, RGS4, VGF, SLC16A12
 89
DESCARTES_FETAL_STOMACH_NEUROENDOCRINE_CELLS 4.36e-08 63.50 18.80 1.46e-06 2.93e-05
5CHGA, SLC18A1, VWA5B2, RGS4, ST18
 50
GAO_LARGE_INTESTINE_ADULT_CA_ENTEROENDOCRINE_CELLS 1.58e-17 37.16 18.65 2.66e-15 1.06e-14
15CHGB, SCG2, RAMP1, INSM1, SLC18A1, PCSK1N, ARC, VWA5B2, RGS4, SCG5, VGF, ST18, CNIH2, SYT4, SLC16A12
 312
DESCARTES_FETAL_INTESTINE_CHROMAFFIN_CELLS 4.35e-11 47.07 18.65 2.92e-09 2.92e-08
8CHGA, SCG2, SLC18A1, PCSK1N, PNMT, VWA5B2, MIR7-3HG, ST18
 112
BUSSLINGER_DUODENAL_K_CELLS 7.60e-06 96.27 17.52 1.82e-04 5.10e-03
3CHGA, SCG2, SCG5
 20
BUSSLINGER_GASTRIC_G_CELLS 7.79e-10 45.99 17.02 3.73e-08 5.23e-07
7CHGB, SCG2, INSM1, PCSK1N, SCG5, ARFGEF3, PCSK2
 98
MURARO_PANCREAS_ALPHA_CELL 7.23e-18 26.35 13.83 1.62e-15 4.85e-15
18CHGA, CHGB, SCG2, PCSK1N, VWA5B2, QDPR, RGS4, SCG5, ARFGEF3, CNTN1, PCSK2, SEZ6L2, VGF, ST18, CNIH2, P4HTM, C2CD4A, SYT4
 568
ZHONG_PFC_C2_THY1_POS_OPC 1.93e-05 68.27 12.75 4.29e-04 1.30e-02
3PCSK1N, SCG5, CNTN1
 27
BUSSLINGER_GASTRIC_X_CELLS 3.02e-09 26.78 10.72 1.19e-07 2.02e-06
8CHGB, PCSK1N, VWA5B2, QDPR, ARFGEF3, SEZ6L2, ST18, SYT4
 191
MANNO_MIDBRAIN_NEUROTYPES_HSERT 1.84e-12 20.70 10.03 1.55e-10 1.24e-09
13CHGA, CHGB, SCG2, PCSK1N, QDPR, SCG5, ARFGEF3, CNTN1, MEG3, SEZ6L2, VGF, CCSER1, CNIH2
 450
MANNO_MIDBRAIN_NEUROTYPES_HDA1 1.38e-13 19.41 9.79 1.32e-11 9.23e-11
15CHGA, SCG2, INSM1, TH, SLC18A1, PCSK1N, SCG5, CNTN1, PCSK2, MEG3, SEZ6L2, VGF, CCSER1, DLK1, SYT4
 584

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_PANCREAS_BETA_CELLS 6.40e-05 44.36 8.46 3.20e-03 3.20e-03
3CHGA, INSM1, PCSK2
 40
HALLMARK_SPERMATOGENESIS 1.34e-04 17.09 4.41 3.35e-03 6.70e-03
4PCSK1N, SCG5, CNIH2, ACE
 135
HALLMARK_KRAS_SIGNALING_UP 6.73e-03 8.34 1.65 1.12e-01 3.37e-01
3PCSK1N, SCG5, ACE
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 5.67e-02 5.42 0.63 6.74e-01 1.00e+00
2SCG2, RGS4
 200
HALLMARK_HEDGEHOG_SIGNALING 6.74e-02 15.01 0.36 6.74e-01 1.00e+00
1SCG2
 36
HALLMARK_UV_RESPONSE_DN 2.43e-01 3.68 0.09 1.00e+00 1.00e+00
1RGS4
 144
HALLMARK_IL2_STAT5_SIGNALING 3.19e-01 2.66 0.07 1.00e+00 1.00e+00
1PENK
 199
HALLMARK_ADIPOGENESIS 3.20e-01 2.64 0.07 1.00e+00 1.00e+00
1QDPR
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 3.20e-01 2.64 0.07 1.00e+00 1.00e+00
1TH
 200
HALLMARK_APICAL_JUNCTION 3.20e-01 2.64 0.07 1.00e+00 1.00e+00
1CNTN1
 200
HALLMARK_MTORC1_SIGNALING 3.20e-01 2.64 0.07 1.00e+00 1.00e+00
1QDPR
 200
HALLMARK_ALLOGRAFT_REJECTION 3.20e-01 2.64 0.07 1.00e+00 1.00e+00
1CARTPT
 200
HALLMARK_KRAS_SIGNALING_DN 3.20e-01 2.64 0.07 1.00e+00 1.00e+00
1PNMT
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_MITOTIC_SPINDLE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 199
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 87

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_TYROSINE_METABOLISM 7.41e-05 42.10 8.05 1.38e-02 1.38e-02
3TH, DBH, PNMT
 42
KEGG_FOLATE_BIOSYNTHESIS 2.11e-02 52.51 1.19 1.00e+00 1.00e+00
1QDPR
 11
KEGG_PARKINSONS_DISEASE 2.61e-02 8.38 0.98 1.00e+00 1.00e+00
2TH, SLC18A1
 130
KEGG_RENIN_ANGIOTENSIN_SYSTEM 3.24e-02 32.79 0.77 1.00e+00 1.00e+00
1ACE
 17
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 1.13e-01 8.62 0.21 1.00e+00 1.00e+00
1NLRP1
 62
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 1.48e-01 6.41 0.16 1.00e+00 1.00e+00
1ACE
 83
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 1.99e-01 4.61 0.11 1.00e+00 1.00e+00
1RAMP1
 115
KEGG_AXON_GUIDANCE 2.21e-01 4.11 0.10 1.00e+00 1.00e+00
1UNC5A
 129
KEGG_CELL_ADHESION_MOLECULES_CAMS 2.27e-01 3.98 0.10 1.00e+00 1.00e+00
1CNTN1
 133
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 4.08e-01 1.94 0.05 1.00e+00 1.00e+00
1CHRNA3
 272
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_GLYCEROLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 49
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 25
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 77
KEGG_ETHER_LIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 33
KEGG_ARACHIDONIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 58

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr20p12 1.72e-02 10.52 1.22 1.00e+00 1.00e+00
2CHGB, PCSK2
 104
chr6q23 1.79e-02 10.32 1.20 1.00e+00 1.00e+00
2ARFGEF3, SLC35D3
 106
chr17q23 1.98e-02 9.76 1.13 1.00e+00 1.00e+00
2CYB561, ACE
 112
chr15q22 2.39e-02 8.80 1.02 1.00e+00 1.00e+00
2C2CD4A, HACD3
 124
chr20p11 3.19e-02 7.51 0.88 1.00e+00 1.00e+00
2INSM1, CFAP61
 145
chr14q32 8.49e-02 3.03 0.60 1.00e+00 1.00e+00
3CHGA, MEG3, DLK1
 546
chr1q23 6.53e-02 4.99 0.58 1.00e+00 1.00e+00
2RGS4, RGS5
 217
chr3p21 1.15e-01 3.55 0.42 1.00e+00 1.00e+00
2NT5DC2, P4HTM
 304
chrXp11 1.57e-01 2.92 0.34 1.00e+00 1.00e+00
2PCSK1N, DGKK
 370
chr12q12 1.06e-01 9.22 0.23 1.00e+00 1.00e+00
1CNTN1
 58
chr4q22 1.27e-01 7.62 0.19 1.00e+00 1.00e+00
1CCSER1
 70
chr8q11 1.27e-01 7.62 0.19 1.00e+00 1.00e+00
1ST18
 70
chr18q11 1.43e-01 6.65 0.16 1.00e+00 1.00e+00
1ANKRD29
 80
chr2q36 1.47e-01 6.49 0.16 1.00e+00 1.00e+00
1SCG2
 82
chr15q13 1.55e-01 6.11 0.15 1.00e+00 1.00e+00
1SCG5
 87
chr8q12 1.57e-01 6.04 0.15 1.00e+00 1.00e+00
1PENK
 88
chrXq23 1.58e-01 5.97 0.15 1.00e+00 1.00e+00
1SERTM2
 89
chr18q12 1.70e-01 5.53 0.14 1.00e+00 1.00e+00
1SYT4
 96
chr3q27 1.99e-01 4.61 0.11 1.00e+00 1.00e+00
1VWA5B2
 115
chr6q22 2.06e-01 4.46 0.11 1.00e+00 1.00e+00
1FAM162B
 119

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
NRSF_01 3.73e-05 24.08 6.17 1.41e-02 4.22e-02
4CHGA, PCSK2, VGF, SYT4
 97
MIER1_TARGET_GENES 5.22e-07 13.37 5.38 5.91e-04 5.91e-04
8CHGB, SCG2, CARTPT, VWA5B2, MIR7-3HG, SEZ6L2, VGF, CNIH2
 375
ATF_B 3.29e-05 15.39 4.71 1.41e-02 3.73e-02
5CHGB, SCG2, TH, SEZ6L2, VGF
 191
TGACGTCA_ATF3_Q6 8.72e-05 12.44 3.82 1.71e-02 9.88e-02
5CHGB, SCG2, TH, SEZ6L2, VGF
 235
ATF1_Q6 9.07e-05 12.34 3.79 1.71e-02 1.03e-01
5CHGB, SCG2, TH, SEZ6L2, VGF
 237
CAGNWMCNNNGAC_UNKNOWN 6.62e-04 19.34 3.78 7.50e-02 7.50e-01
3CHGA, CHGB, SYT4
 88
CREBP1_Q2 1.39e-04 11.23 3.45 2.02e-02 1.58e-01
5CHGB, SCG2, TH, SEZ6L2, VGF
 260
CREBP1CJUN_01 1.50e-04 11.05 3.40 2.02e-02 1.69e-01
5CHGB, SCG2, TH, SEZ6L2, VGF
 264
CREB_01 1.60e-04 10.88 3.34 2.02e-02 1.82e-01
5CHGB, SCG2, TH, SEZ6L2, VGF
 268
BAHD1_TARGET_GENES 2.60e-03 28.99 3.29 1.47e-01 1.00e+00
2PENK, MIR7-3HG
 39
TGAYRTCA_ATF3_Q6 7.52e-05 7.74 2.92 1.71e-02 8.52e-02
7CHGB, SCG2, TH, CARTPT, PCSK2, SEZ6L2, VGF
 549
CREB_Q4_01 8.01e-04 10.51 2.72 8.26e-02 9.08e-01
4CHGB, SCG2, TH, SEZ6L2
 217
GGGNNTTTCC_NFKB_Q6_01 2.21e-03 12.55 2.47 1.32e-01 1.00e+00
3C1QL1, PCSK2, CNIH2
 134
ATF3_Q6 1.41e-03 8.99 2.33 1.15e-01 1.00e+00
4CHGB, SCG2, INSM1, SEZ6L2
 253
CREB_02 1.55e-03 8.75 2.27 1.15e-01 1.00e+00
4CHGB, SCG2, PCSK2, SEZ6L2
 260
ATF_01 1.71e-03 8.52 2.21 1.15e-01 1.00e+00
4CHGB, SCG2, TH, SEZ6L2
 267
CREB_Q2 1.76e-03 8.45 2.19 1.15e-01 1.00e+00
4CHGB, SCG2, PENK, SEZ6L2
 269
EGR1_01 1.76e-03 8.45 2.19 1.15e-01 1.00e+00
4PCSK2, SEZ6L2, VGF, ACE
 269
CREB_Q4 1.83e-03 8.36 2.17 1.15e-01 1.00e+00
4CHGB, SCG2, PENK, SEZ6L2
 272
RBMX_TARGET_GENES 1.35e-02 87.42 1.87 5.39e-01 1.00e+00
1MIR7-3HG
 7

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_NOREPINEPHRINE_BIOSYNTHETIC_PROCESS 2.38e-07 406.69 58.21 4.45e-04 1.78e-03
3INSM1, TH, DBH
 7
GOBP_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 5.88e-08 139.68 32.68 1.74e-04 4.40e-04
4INSM1, TH, DBH, PNMT
 20
GOBP_NOREPINEPHRINE_METABOLIC_PROCESS 1.93e-06 163.67 28.07 1.80e-03 1.44e-02
3INSM1, TH, DBH
 13
GOBP_SIGNALING_RECEPTOR_LIGAND_PRECURSOR_PROCESSING 4.87e-07 77.25 18.93 7.28e-04 3.64e-03
4PCSK1N, SCG5, PCSK2, ACE
 33
GOBP_AMINE_TRANSPORT 5.80e-10 48.13 17.78 4.34e-06 4.34e-06
7CHGA, TH, CARTPT, SLC18A1, CHRNA3, RGS4, SYT4
 94
GOBP_NEUROTRANSMITTER_LOADING_INTO_SYNAPTIC_VESICLE 1.02e-04 177.85 17.16 2.65e-02 7.64e-01
2TH, SLC18A1
 8
GOBP_AMINE_BIOSYNTHETIC_PROCESS 9.69e-07 63.88 15.85 1.21e-03 7.25e-03
4INSM1, TH, DBH, PNMT
 39
GOBP_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 1.44e-06 57.35 14.31 1.54e-03 1.08e-02
4INSM1, TH, DBH, PNMT
 43
GOBP_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT 1.72e-05 71.33 13.27 7.32e-03 1.29e-01
3CHGA, RGS4, SYT4
 26
GOBP_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS 3.12e-06 46.57 11.73 2.60e-03 2.34e-02
4INSM1, TH, DBH, PNMT
 52
GOBP_RESPONSE_TO_AMPHETAMINE 2.67e-05 60.79 11.42 1.05e-02 2.00e-01
3TH, DBH, RGS4
 30
GOBP_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION 2.83e-04 97.16 10.22 5.33e-02 1.00e+00
2CHGA, SYT4
 13
GOBP_GANGLION_DEVELOPMENT 4.33e-04 76.37 8.22 7.90e-02 1.00e+00
2INSM1, RGS4
 16
GOBP_RESPONSE_TO_AMINE 7.41e-05 42.10 8.05 2.13e-02 5.54e-01
3TH, DBH, RGS4
 42
GOBP_RESPONSE_TO_NICOTINE 7.95e-05 41.01 7.86 2.20e-02 5.95e-01
3PENK, TH, CHRNA3
 43
GOBP_MONOAMINE_TRANSPORT 1.66e-05 29.85 7.61 7.32e-03 1.24e-01
4CHGA, CARTPT, SLC18A1, SYT4
 79
GOBP_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS 5.51e-04 67.02 7.27 9.81e-02 1.00e+00
2TH, DBH
 18
GOBP_LEARNING 5.17e-06 22.87 6.97 3.87e-03 3.87e-02
5C1QL1, TH, DBH, ARC, SLC24A2
 130
GOBP_CATECHOLAMINE_SECRETION 1.49e-04 32.83 6.33 3.59e-02 1.00e+00
3CHGA, CARTPT, SYT4
 53
GOBP_CELLULAR_BIOGENIC_AMINE_METABOLIC_PROCESS 4.71e-05 22.60 5.80 1.63e-02 3.52e-01
4INSM1, TH, DBH, PNMT
 103

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE43956_WT_VS_SGK1_KO_TH17_DIFFERENTIATED_CD4_TCELL_UP 4.09e-05 14.68 4.50 1.99e-01 1.99e-01
5CHGB, PENK, CYB561, QDPR, MEG3
 200
GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_DN 5.39e-04 11.73 3.04 2.62e-01 1.00e+00
4RAMP1, CHRNA3, SLC24A2, PCSK2
 195
GSE20727_ROS_INH_VS_ROS_INH_AND_DNFB_ALLERGEN_TREATED_DC_DN 5.49e-04 11.66 3.02 2.62e-01 1.00e+00
4CARTPT, CHRNA3, CNIH2, CFAP61
 196
GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_24H_UP 5.71e-04 11.54 2.99 2.62e-01 1.00e+00
4SCG2, RAMP1, DBH, CNTN1
 198
GSE12845_IGD_POS_VS_NEG_BLOOD_BCELL_UP 5.81e-04 11.49 2.97 2.62e-01 1.00e+00
4RAMP1, PENK, DBH, NLRP1
 199
GSE45365_NK_CELL_VS_CD8A_DC_DN 5.81e-04 11.49 2.97 2.62e-01 1.00e+00
4TH, CNTN1, DGKK, SEZ6L2
 199
GSE13229_MATURE_VS_INTMATURE_NKCELL_UP 5.92e-04 11.43 2.96 2.62e-01 1.00e+00
4RAMP1, PENK, CCSER1, ACE
 200
GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_NAIVE_CD4_TCELL_DN 5.92e-04 11.43 2.96 2.62e-01 1.00e+00
4PNMT, SLC35D3, DLK1, ZDBF2
 200
GSE22886_DC_VS_MONOCYTE_UP 5.92e-04 11.43 2.96 2.62e-01 1.00e+00
4RAMP1, NT5DC2, ACE, HACD3
 200
GSE4142_NAIVE_VS_MEMORY_BCELL_DN 5.92e-04 11.43 2.96 2.62e-01 1.00e+00
4PNMT, SLC24A2, FAM162B, HACD3
 200
GSE23502_BM_VS_COLON_TUMOR_HDC_KO_MYELOID_DERIVED_SUPPRESSOR_CELL_UP 5.92e-04 11.43 2.96 2.62e-01 1.00e+00
4SLC18A1, CHRNA3, SLC24A2, SEZ6L2
 200
GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP 2.55e-03 11.91 2.34 7.45e-01 1.00e+00
3CHGB, TH, PNMT
 141
GSE40274_CTRL_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 3.83e-03 10.27 2.02 7.45e-01 1.00e+00
3CHGA, TH, FAM162B
 163
GSE40274_CTRL_VS_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 4.31e-03 9.84 1.94 7.45e-01 1.00e+00
3PENK, ST18, CNIH2
 170
GSE15215_CD2_POS_VS_NEG_PDC_UP 6.37e-03 8.52 1.68 7.45e-01 1.00e+00
3NT5DC2, NLRP1, ACE
 196
GSE22886_NEUTROPHIL_VS_MONOCYTE_UP 6.46e-03 8.47 1.67 7.45e-01 1.00e+00
3CHRNA3, RGS4, VGF
 197
GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_DN 6.46e-03 8.47 1.67 7.45e-01 1.00e+00
3SLC18A1, PCSK2, RGS5
 197
GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN 6.46e-03 8.47 1.67 7.45e-01 1.00e+00
3SCG2, DBH, CNTN1
 197
GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN 6.55e-03 8.43 1.66 7.45e-01 1.00e+00
3CHGA, SCG2, SCG5
 198
GSE11961_PLASMA_CELL_DAY7_VS_MEMORY_BCELL_DAY40_DN 6.55e-03 8.43 1.66 7.45e-01 1.00e+00
3SLC18A1, ARFGEF3, CNIH2
 198

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
INSM1 6 Yes Known motif Monomer or homomultimer In vivo/Misc source None None
ST18 38 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
ADGRA1 60 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZNF331 81 Yes Known motif Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE) None
INS 87 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NPAS4 88 Yes Inferred motif Obligate heteromer High-throughput in vitro None Likely dimerizes with ARNT2 (PMID:24263188).
BEX1 100 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Likely a cofactor- (PMID: 16314316) shows results for related BEX2
HAND2 113 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NR4A1 156 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
GPR155 162 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PHOX2A 166 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NKX6-2 180 Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None
TRIM29 183 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Previous evidence for TF activity (PMID: 8188213) is based on sequence analysis and does not provide DNA-binding evidence. Based on EntrezGene information, its likely a transcriptional co-factor
KLF13 185 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TLX2 187 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
BTG2 190 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor (PMID: 10617598)
VEGFA 200 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Extracellular signaling molecule. Included only because it regulates CREB.
JUND 203 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TBX20 227 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HMGN3 237 Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
R63_w12GP_GATGAGGCAACTTCTT-1 Neurons:adrenal_medulla_cell_line 0.17 1612.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_2lox-22: 0.37, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.37, Embryonic_stem_cells: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_2lox-17: 0.37
R48a_w14.5_TGGCGTGAGGTTATAG-1 Neurons:adrenal_medulla_cell_line 0.17 1559.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.41, Neurons:Schwann_cell: 0.4, iPS_cells:PDB_1lox-17Puro-10: 0.4, iPS_cells:PDB_1lox-21Puro-20: 0.4, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.4, iPS_cells:skin_fibroblast-derived: 0.4, iPS_cells:PDB_2lox-5: 0.4, Embryonic_stem_cells: 0.39
R48a_w14.5_ATCTCTATCCTTCACG-1 Neurons:adrenal_medulla_cell_line 0.17 1468.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-5: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_2lox-17: 0.35
R48b_w12_GGTGTCGAGGTGCTTT-1 Neurons:adrenal_medulla_cell_line 0.20 997.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.5, Neuroepithelial_cell:ESC-derived: 0.43, Astrocyte:Embryonic_stem_cell-derived: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_2lox-22: 0.4, Embryonic_stem_cells: 0.4, iPS_cells:PDB_2lox-17: 0.4
R48a_w14.5_ATCGTGAGTTTAGACC-1 Neurons:adrenal_medulla_cell_line 0.19 838.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.39, iPS_cells:PDB_1lox-17Puro-5: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.38, iPS_cells:PDB_2lox-5: 0.38
R63_w12GP_GTTCCGTGTTGCTGAT-1 Neurons:adrenal_medulla_cell_line 0.13 768.49
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-5: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.32, iPS_cells:iPS:minicircle-derived: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_2lox-21: 0.32
R53a_w9.5_CTTCAATTCTGTACAG-1 Neurons:adrenal_medulla_cell_line 0.16 734.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, iPS_cells:PDB_2lox-22: 0.32
R30_w8.5_CGTAATGTCTGGGCAC-1 Neurons:adrenal_medulla_cell_line 0.16 720.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.35, iPS_cells:PDB_2lox-5: 0.35, iPS_cells:PDB_2lox-17: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:iPS:minicircle-derived: 0.35
R53a_w9.5_TTTACCAGTGAGCCAA-1 Neurons:adrenal_medulla_cell_line 0.16 712.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.43, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.41, Neurons:ES_cell-derived_neural_precursor: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.41, iPS_cells:PDB_2lox-22: 0.4, Astrocyte:Embryonic_stem_cell-derived: 0.4
R63_w12GP_GAAGGGTGTGGAACAC-1 Neurons:adrenal_medulla_cell_line 0.14 707.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.36, iPS_cells:PDB_2lox-17: 0.36
R63_w12GP_CATACCCAGCCATATC-1 Neurons:adrenal_medulla_cell_line 0.14 707.41
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_2lox-5: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, Neurons:Schwann_cell: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25
R53a_w9.5_GTCAAGTCACCCTTAC-1 Neurons:adrenal_medulla_cell_line 0.17 688.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_2lox-22: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-21: 0.34
R48a_w14.5_CTTCAATTCGTTCTCG-1 Neurons:adrenal_medulla_cell_line 0.15 686.34
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neurons:Schwann_cell: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, Embryonic_stem_cells: 0.33
R53a_w9.5_TCAATTCGTATGCTTG-1 Neurons:adrenal_medulla_cell_line 0.18 684.80
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.44, iPS_cells:PDB_1lox-21Puro-20: 0.42, iPS_cells:PDB_1lox-17Puro-5: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.42, iPS_cells:PDB_1lox-21Puro-26: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:PDB_2lox-22: 0.41, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.41, iPS_cells:PDB_2lox-5: 0.41
R48a_w14.5_CTACTATTCTTGCGCT-1 Neurons:adrenal_medulla_cell_line 0.16 681.86
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, MSC: 0.34, Neurons:Schwann_cell: 0.34, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.34, iPS_cells:iPS:minicircle-derived: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:skin_fibroblast-derived: 0.34
R48c_w8.5_ATCGCCTTCCTCGCAT-1 Neurons:adrenal_medulla_cell_line 0.17 674.93
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.4, Neurons:Schwann_cell: 0.39, Embryonic_stem_cells: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37
R48a_w14.5_CCGAACGTCTAATTCC-1 Neurons:adrenal_medulla_cell_line 0.18 672.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, Neurons:Schwann_cell: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_2lox-5: 0.36
R53a_w9.5_CCGGTGATCTCTCGCA-1 Neurons:adrenal_medulla_cell_line 0.16 671.81
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32
R48a_w14.5_GATGCTAGTGGTACAG-1 Neurons:adrenal_medulla_cell_line 0.15 662.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:skin_fibroblast-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Embryonic_stem_cells: 0.32, iPS_cells:iPS:minicircle-derived: 0.32
R30_w8.5_TCGCTCATCAGACATC-1 Neurons:adrenal_medulla_cell_line 0.15 655.91
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_2lox-5: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_2lox-22: 0.28
R48a_w14.5_GTGCAGCGTTTCGTGA-1 Neurons:adrenal_medulla_cell_line 0.15 652.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-5: 0.33
R53c_w9.5_TGTTCTAAGTAGCCAG-1 Neurons:adrenal_medulla_cell_line 0.16 650.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.42, iPS_cells:PDB_1lox-17Puro-5: 0.4, iPS_cells:PDB_1lox-17Puro-10: 0.4, iPS_cells:PDB_1lox-21Puro-20: 0.4, iPS_cells:PDB_1lox-21Puro-26: 0.4, Astrocyte:Embryonic_stem_cell-derived: 0.4, iPS_cells:PDB_2lox-22: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.4, iPS_cells:PDB_2lox-21: 0.39
R48a_w14.5_TTCTTCCTCATCTATC-1 Neurons:adrenal_medulla_cell_line 0.17 633.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.35, iPS_cells:PDB_2lox-5: 0.35
R53a_w9.5_TTTGGTTGTGCCGTTG-1 Neurons:adrenal_medulla_cell_line 0.17 626.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, Embryonic_stem_cells: 0.34
R63_w12GP_CACGGGTGTTTACTGG-1 Endothelial_cells:blood_vessel 0.14 619.92
Raw ScoresEndothelial_cells:lymphatic: 0.39, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:lymphatic:KSHV: 0.39, Endothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:HUVEC: 0.38, Endothelial_cells:HUVEC:FPV-infected: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.37, Endothelial_cells:HUVEC:VEGF: 0.37, Endothelial_cells:HUVEC:H5N1-infected: 0.37
R48a_w14.5_ATGTCCCTCTCACCCA-1 Neurons:adrenal_medulla_cell_line 0.19 611.18
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_2lox-21: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.35
R53a_w9.5_GTACAACCAGCGTTGC-1 Neurons:adrenal_medulla_cell_line 0.15 605.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-21: 0.34
R39_w9.5_CAGCCAGTCATCCTGC-1 Neurons:adrenal_medulla_cell_line 0.14 603.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neurons:Schwann_cell: 0.31, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.31, MSC: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.31, Tissue_stem_cells:CD326-CD56+: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31
R30_w8.5_TTGTGGAGTCTGTAAC-1 Neurons:adrenal_medulla_cell_line 0.18 602.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.36, Embryonic_stem_cells: 0.36
R48a_w14.5_TGAGCATGTCAGGCAA-1 Neurons:adrenal_medulla_cell_line 0.16 594.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:Schwann_cell: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, Embryonic_stem_cells: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, iPS_cells:skin_fibroblast-derived: 0.32, iPS_cells:PDB_2lox-5: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.31
R53a_w9.5_TGCCGAGTCCAGGACC-1 Neurons:adrenal_medulla_cell_line 0.16 590.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_2lox-22: 0.31
R63_w12GP_ACGTAGTTCACTTTGT-1 Neurons:adrenal_medulla_cell_line 0.13 586.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:iPS:minicircle-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32
R53a_w9.5_TCAAGTGCACGCGCTA-1 Neurons:adrenal_medulla_cell_line 0.21 578.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.52, Neuroepithelial_cell:ESC-derived: 0.49, iPS_cells:PDB_2lox-22: 0.48, iPS_cells:PDB_1lox-17Puro-10: 0.48, iPS_cells:PDB_1lox-21Puro-20: 0.48, iPS_cells:PDB_1lox-17Puro-5: 0.48, iPS_cells:PDB_1lox-21Puro-26: 0.48, iPS_cells:PDB_2lox-17: 0.47, iPS_cells:PDB_2lox-21: 0.47, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.47
R48a_w14.5_CTTCCGAAGCCTTTGA-1 Neurons:adrenal_medulla_cell_line 0.17 574.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Embryonic_stem_cells: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.3
R48b_w12_TCTGCCAGTGTCTAAC-1 Neurons:adrenal_medulla_cell_line 0.18 571.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-17: 0.34, Embryonic_stem_cells: 0.34
R63_w12GP_CGTAGTACAGAAGCGT-1 Neurons:adrenal_medulla_cell_line 0.12 567.04
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:iPS:minicircle-derived: 0.27, iPS_cells:PDB_2lox-5: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-17: 0.27, iPS_cells:skin_fibroblast-derived: 0.27, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.27
R53a_w9.5_TCTCTGGCAACTCGAT-1 Neurons:adrenal_medulla_cell_line 0.17 566.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_2lox-17: 0.36, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.36, iPS_cells:PDB_2lox-21: 0.35
R63_w12GP_CCTCTAGTCGTGCACG-1 Neurons:adrenal_medulla_cell_line 0.15 564.48
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-5: 0.33
R53a_w9.5_CATTCCGAGTCAGCGA-1 Neurons:adrenal_medulla_cell_line 0.17 563.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.39, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_2lox-5: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_2lox-17: 0.38, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37
R63_w12GP_CTAAGTGGTGGATTTC-1 Neurons:adrenal_medulla_cell_line 0.12 557.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.3, iPS_cells:iPS:minicircle-derived: 0.3, iPS_cells:PDB_2lox-5: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, Embryonic_stem_cells: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-22: 0.3
R30_w8.5_GAGTGAGAGCTAGAAT-1 Neurons:adrenal_medulla_cell_line 0.21 556.77
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.49, Neuroepithelial_cell:ESC-derived: 0.44, iPS_cells:PDB_1lox-17Puro-5: 0.42, iPS_cells:PDB_1lox-21Puro-20: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.42, iPS_cells:PDB_1lox-21Puro-26: 0.42, iPS_cells:PDB_2lox-22: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.41, iPS_cells:PDB_2lox-17: 0.41
R53a_w9.5_GTGAGGAAGCACAAAT-1 Neurons:adrenal_medulla_cell_line 0.16 556.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32
R53a_w9.5_GCACATATCGCACTCT-1 Neurons:adrenal_medulla_cell_line 0.18 548.18
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.4, iPS_cells:PDB_1lox-21Puro-20: 0.4, iPS_cells:PDB_1lox-17Puro-10: 0.4, iPS_cells:PDB_1lox-17Puro-5: 0.4, Astrocyte:Embryonic_stem_cell-derived: 0.4, iPS_cells:PDB_2lox-22: 0.4, iPS_cells:PDB_1lox-21Puro-26: 0.4, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.39
R48a_w14.5_TCAAGTGAGGGCTAAC-1 Neurons:adrenal_medulla_cell_line 0.13 543.11
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Embryonic_stem_cells: 0.32
R30_w8.5_TCTACATTCGTTCTAT-1 Neurons:adrenal_medulla_cell_line 0.15 540.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, Neurons:Schwann_cell: 0.32, Embryonic_stem_cells: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_2lox-5: 0.32, iPS_cells:iPS:minicircle-derived: 0.31, iPS_cells:PDB_2lox-22: 0.31
R53c_w9.5_AATCGACGTAGGATAT-1 Neurons:adrenal_medulla_cell_line 0.19 539.60
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-5: 0.34
R63_w12GP_TTCCTCTAGTAACGTA-1 Neurons:adrenal_medulla_cell_line 0.15 535.00
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-5: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.31, iPS_cells:PDB_2lox-21: 0.31
R48c_w8.5_CATAGACAGCATTGAA-1 Neurons:adrenal_medulla_cell_line 0.15 530.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_2lox-5: 0.28
R63_w12GP_AGGTCTAGTCCAAGAG-1 Neurons:adrenal_medulla_cell_line 0.14 530.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:iPS:minicircle-derived: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-5: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-17: 0.32, Embryonic_stem_cells: 0.32
R48b_w12_ACACTGACAAGACCTT-1 Neurons:adrenal_medulla_cell_line 0.18 524.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-22: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.11e-09
Mean rank of genes in gene set: 2408.35
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
C1QL1 0.0126086 7 GTEx DepMap Descartes 4.41 675.65
SCG5 0.0073173 26 GTEx DepMap Descartes 3.46 602.98
SLC35D3 0.0071926 30 GTEx DepMap Descartes 0.38 33.13
PTPRN 0.0057951 51 GTEx DepMap Descartes 0.94 51.42
GNAS 0.0049285 78 GTEx DepMap Descartes 29.50 1678.68
PCLO 0.0036895 123 GTEx DepMap Descartes 1.53 22.77
ADCYAP1R1 0.0034342 141 GTEx DepMap Descartes 0.32 14.27
SCG3 0.0026224 215 GTEx DepMap Descartes 1.27 97.12
CELF4 0.0025817 224 GTEx DepMap Descartes 1.09 80.93
NAP1L5 0.0023978 264 GTEx DepMap Descartes 0.73 87.14
CACNA2D1 0.0023471 273 GTEx DepMap Descartes 0.92 35.23
SYN2 0.0009546 1018 GTEx DepMap Descartes 0.11 7.66
PPFIA2 0.0008845 1135 GTEx DepMap Descartes 0.25 13.10
SNAP25 0.0006311 1644 GTEx DepMap Descartes 1.15 127.18
SLCO3A1 0.0004082 2531 GTEx DepMap Descartes 0.55 30.18
LGR5 0.0000164 9198 GTEx DepMap Descartes 0.02 1.70
CXCL14 -0.0003485 23984 GTEx DepMap Descartes 0.01 1.30


Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.53e-08
Mean rank of genes in gene set: 2901.12
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CHGA 0.0176475 1 GTEx DepMap Descartes 94.32 11651.42
CHGB 0.0163608 2 GTEx DepMap Descartes 49.98 4972.72
TH 0.0120792 8 GTEx DepMap Descartes 10.05 1450.43
DBH 0.0113835 10 GTEx DepMap Descartes 11.94 1169.41
SLC18A1 0.0107091 12 GTEx DepMap Descartes 3.69 355.15
PCSK1N 0.0102016 13 GTEx DepMap Descartes 14.78 3168.28
CYB561 0.0092274 16 GTEx DepMap Descartes 3.01 267.13
DDC 0.0055085 61 GTEx DepMap Descartes 2.09 261.04
HAND2 0.0039656 113 GTEx DepMap Descartes 4.48 425.31
PHOX2A 0.0030858 166 GTEx DepMap Descartes 3.72 514.74
EML5 0.0022589 288 GTEx DepMap Descartes 2.37 77.91
GATA3 0.0021034 324 GTEx DepMap Descartes 2.27 214.28
NNAT 0.0008020 1265 GTEx DepMap Descartes 2.36 416.79
UCHL1 0.0004498 2325 GTEx DepMap Descartes 2.94 397.03
PHOX2B 0.0003534 2879 GTEx DepMap Descartes 1.98 174.02
DISP2 -0.0000619 16383 GTEx DepMap Descartes 0.10 1.79
MAP1B -0.0006552 25453 GTEx DepMap Descartes 4.23 91.76


Committed Progenitor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Committed Progenitor subcluster (seems to mean progenitor of chromaffin cells), which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.53e-06
Mean rank of genes in gene set: 4475.29
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RGS4 0.0074418 25 GTEx DepMap Descartes 7.25 516.11
MEG3 0.0070788 32 GTEx DepMap Descartes 69.04 1877.73
DGKK 0.0069569 33 GTEx DepMap Descartes 1.07 37.75
RGS5 0.0068912 35 GTEx DepMap Descartes 15.06 667.31
ZDBF2 0.0060973 47 GTEx DepMap Descartes 2.43 71.71
SLC18A2 0.0057327 53 GTEx DepMap Descartes 1.48 96.41
SYT1 0.0053281 65 GTEx DepMap Descartes 4.79 274.74
FAM155A 0.0050121 77 GTEx DepMap Descartes 0.71 21.69
NDUFA4L2 0.0041498 104 GTEx DepMap Descartes 2.00 404.94
UNC5C 0.0034238 142 GTEx DepMap Descartes 1.20 37.32
ATP6V1B2 0.0030603 168 GTEx DepMap Descartes 1.82 68.75
C2CD4B 0.0022325 292 GTEx DepMap Descartes 1.25 190.85
PARM1 0.0009630 1006 GTEx DepMap Descartes 0.21 11.94
SYTL4 0.0003292 3064 GTEx DepMap Descartes 0.70 38.71
NTRK3 -0.0001927 21683 GTEx DepMap Descartes 0.08 0.85
AGTR2 -0.0003134 23617 GTEx DepMap Descartes 0.04 2.17
NRK -0.0007925 25637 GTEx DepMap Descartes 0.24 4.31




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.98e-06
Mean rank of genes in gene set: 11166.78
Median rank of genes in gene set: 6002
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHGA 0.0176475 1 GTEx DepMap Descartes 94.32 11651.42
CHGB 0.0163608 2 GTEx DepMap Descartes 49.98 4972.72
SCG2 0.0147153 3 GTEx DepMap Descartes 12.62 1285.25
INSM1 0.0131589 6 GTEx DepMap Descartes 3.54 307.92
TH 0.0120792 8 GTEx DepMap Descartes 10.05 1450.43
DBH 0.0113835 10 GTEx DepMap Descartes 11.94 1169.41
CHRNA3 0.0091114 17 GTEx DepMap Descartes 3.53 326.62
QDPR 0.0075939 24 GTEx DepMap Descartes 4.46 649.01
RGS5 0.0068912 35 GTEx DepMap Descartes 15.06 667.31
DLK1 0.0065554 40 GTEx DepMap Descartes 46.63 2296.78
SYT4 0.0061707 45 GTEx DepMap Descartes 1.21 80.02
GCH1 0.0055731 58 GTEx DepMap Descartes 1.41 112.35
DDC 0.0055085 61 GTEx DepMap Descartes 2.09 261.04
SYT1 0.0053281 65 GTEx DepMap Descartes 4.79 274.74
EEF1A2 0.0052812 70 GTEx DepMap Descartes 7.07 409.34
PLPPR5 0.0051461 73 GTEx DepMap Descartes 0.65 NA
FAM155A 0.0050121 77 GTEx DepMap Descartes 0.71 21.69
BEX2 0.0042412 97 GTEx DepMap Descartes 4.12 816.42
BEX1 0.0042328 100 GTEx DepMap Descartes 8.60 2323.67
GPR22 0.0040260 108 GTEx DepMap Descartes 1.20 96.79
GRIA2 0.0040200 109 GTEx DepMap Descartes 2.35 127.40
HAND2-AS1 0.0036133 129 GTEx DepMap Descartes 4.93 NA
NPTX2 0.0035632 133 GTEx DepMap Descartes 0.48 43.53
MIAT 0.0035021 138 GTEx DepMap Descartes 2.29 82.98
ADCYAP1R1 0.0034342 141 GTEx DepMap Descartes 0.32 14.27
PHOX2A 0.0030858 166 GTEx DepMap Descartes 3.72 514.74
SHD 0.0030673 167 GTEx DepMap Descartes 0.99 135.22
ATP6V1B2 0.0030603 168 GTEx DepMap Descartes 1.82 68.75
STXBP1 0.0030361 170 GTEx DepMap Descartes 1.55 86.24
KLF13 0.0028691 185 GTEx DepMap Descartes 1.46 57.08


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 18621.14
Median rank of genes in gene set: 23214
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SERPINE2 0.0028270 189 GTEx DepMap Descartes 1.83 82.14
ITM2C 0.0026895 206 GTEx DepMap Descartes 3.46 397.67
CD44 0.0026138 217 GTEx DepMap Descartes 2.07 95.74
ATP1B1 0.0025275 234 GTEx DepMap Descartes 2.39 219.97
HIST1H2AC 0.0021373 310 GTEx DepMap Descartes 1.45 NA
HSPA5 0.0020046 351 GTEx DepMap Descartes 5.23 327.04
ROBO1 0.0019325 379 GTEx DepMap Descartes 0.87 32.88
SHROOM3 0.0018331 406 GTEx DepMap Descartes 0.31 7.49
KLF10 0.0015646 516 GTEx DepMap Descartes 0.95 68.37
NPTN 0.0015249 536 GTEx DepMap Descartes 1.22 103.87
SDC2 0.0014626 565 GTEx DepMap Descartes 0.72 54.04
SURF4 0.0014318 582 GTEx DepMap Descartes 1.68 139.22
PTN 0.0014221 590 GTEx DepMap Descartes 2.87 387.86
EGR1 0.0013516 633 GTEx DepMap Descartes 3.78 304.77
SSBP4 0.0013203 652 GTEx DepMap Descartes 2.10 279.38
LMNA 0.0013001 673 GTEx DepMap Descartes 1.72 126.83
ATP6V0E1 0.0012898 684 GTEx DepMap Descartes 2.40 368.39
DKK3 0.0012589 708 GTEx DepMap Descartes 1.06 27.40
CRELD2 0.0012553 712 GTEx DepMap Descartes 0.69 59.54
MBTPS1 0.0012103 748 GTEx DepMap Descartes 1.13 67.19
MANF 0.0011880 767 GTEx DepMap Descartes 1.57 218.13
DMD 0.0011702 791 GTEx DepMap Descartes 0.96 20.22
SPRY4 0.0011116 836 GTEx DepMap Descartes 0.51 28.29
FAM3C 0.0011059 842 GTEx DepMap Descartes 0.97 91.88
POLR2L 0.0010700 876 GTEx DepMap Descartes 4.66 1078.84
FAM43A 0.0010520 900 GTEx DepMap Descartes 0.56 43.58
NR3C1 0.0009938 960 GTEx DepMap Descartes 0.93 34.53
ALDH1A3 0.0009350 1049 GTEx DepMap Descartes 0.10 9.19
PTPRK 0.0009063 1094 GTEx DepMap Descartes 0.44 NA
STAT3 0.0008969 1111 GTEx DepMap Descartes 1.26 64.17


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 20920.76
Median rank of genes in gene set: 24765.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LINC00473 0.0024218 254 GTEx DepMap Descartes 0.67 NA
JAKMIP2 0.0004762 2196 GTEx DepMap Descartes 0.55 14.67
FRMD5 0.0003543 2874 GTEx DepMap Descartes 0.10 6.07
NPC1 0.0003532 2883 GTEx DepMap Descartes 0.21 13.05
TM7SF2 0.0003506 2906 GTEx DepMap Descartes 1.06 114.62
FREM2 0.0001135 6034 GTEx DepMap Descartes 0.07 1.39
SCARB1 0.0000845 6775 GTEx DepMap Descartes 1.19 56.12
IGF1R -0.0000099 10650 GTEx DepMap Descartes 0.72 16.17
SGCZ -0.0000878 18091 GTEx DepMap Descartes 0.00 0.07
CLU -0.0000949 18427 GTEx DepMap Descartes 0.92 79.51
SLC2A14 -0.0002058 21954 GTEx DepMap Descartes 0.02 0.68
SCAP -0.0002605 22934 GTEx DepMap Descartes 0.44 23.41
ERN1 -0.0002663 23026 GTEx DepMap Descartes 0.17 4.03
SH3PXD2B -0.0002777 23195 GTEx DepMap Descartes 0.11 3.40
PDE10A -0.0002880 23338 GTEx DepMap Descartes 0.09 2.18
DNER -0.0003330 23831 GTEx DepMap Descartes 0.08 5.83
HMGCR -0.0003368 23878 GTEx DepMap Descartes 0.70 34.25
SLC16A9 -0.0003409 23923 GTEx DepMap Descartes 0.22 13.56
CYP17A1 -0.0003754 24188 GTEx DepMap Descartes 1.26 55.39
DHCR7 -0.0004363 24638 GTEx DepMap Descartes 0.22 15.36
PEG3 -0.0004429 24676 GTEx DepMap Descartes 1.30 NA
BAIAP2L1 -0.0004468 24693 GTEx DepMap Descartes 0.04 2.04
CYP11B1 -0.0004550 24743 GTEx DepMap Descartes 0.34 16.53
HMGCS1 -0.0004631 24788 GTEx DepMap Descartes 0.87 34.79
SLC1A2 -0.0004780 24869 GTEx DepMap Descartes 0.04 0.75
CYP21A2 -0.0004799 24877 GTEx DepMap Descartes 0.38 22.78
GSTA4 -0.0004917 24928 GTEx DepMap Descartes 1.16 131.90
SULT2A1 -0.0005120 25027 GTEx DepMap Descartes 0.31 20.83
MSMO1 -0.0005242 25078 GTEx DepMap Descartes 0.72 60.54
PAPSS2 -0.0005473 25160 GTEx DepMap Descartes 0.09 4.00


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 22421.93
Median rank of genes in gene set: 25390
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GAL 0.0022638 287 GTEx DepMap Descartes 4.75 1408.79
STMN2 0.0002681 3643 GTEx DepMap Descartes 14.80 1688.74
EPHA6 0.0000586 7602 GTEx DepMap Descartes 0.04 2.98
MAB21L1 0.0000313 8586 GTEx DepMap Descartes 0.76 68.01
MAB21L2 0.0000213 9001 GTEx DepMap Descartes 0.36 35.03
KCNB2 -0.0000400 14442 GTEx DepMap Descartes 0.03 1.71
EYA4 -0.0000414 14612 GTEx DepMap Descartes 0.18 9.72
NPY -0.0001252 19691 GTEx DepMap Descartes 3.78 965.51
TMEFF2 -0.0002591 22915 GTEx DepMap Descartes 0.13 9.50
ANKFN1 -0.0002848 23296 GTEx DepMap Descartes 0.02 1.22
SLC44A5 -0.0003190 23671 GTEx DepMap Descartes 0.03 1.57
EYA1 -0.0003501 23998 GTEx DepMap Descartes 0.18 12.58
RPH3A -0.0003671 24109 GTEx DepMap Descartes 0.13 7.34
CNTFR -0.0003741 24176 GTEx DepMap Descartes 0.44 58.52
RGMB -0.0003989 24356 GTEx DepMap Descartes 0.32 17.79
RYR2 -0.0004990 24963 GTEx DepMap Descartes 0.04 0.51
TUBB2A -0.0005154 25038 GTEx DepMap Descartes 2.75 316.96
FAT3 -0.0005206 25056 GTEx DepMap Descartes 0.04 0.59
TMEM132C -0.0005560 25201 GTEx DepMap Descartes 0.09 5.31
MLLT11 -0.0005734 25259 GTEx DepMap Descartes 1.84 154.55
REEP1 -0.0005971 25332 GTEx DepMap Descartes 0.24 12.68
HS3ST5 -0.0006191 25376 GTEx DepMap Descartes 0.01 0.78
BASP1 -0.0006305 25404 GTEx DepMap Descartes 2.49 299.79
MAP1B -0.0006552 25453 GTEx DepMap Descartes 4.23 91.76
ALK -0.0006976 25524 GTEx DepMap Descartes 0.04 1.86
CNKSR2 -0.0007394 25579 GTEx DepMap Descartes 0.28 9.81
NTRK1 -0.0008044 25652 GTEx DepMap Descartes 0.06 3.12
ISL1 -0.0009108 25713 GTEx DepMap Descartes 0.98 94.61
GREM1 -0.0010743 25763 GTEx DepMap Descartes 0.06 1.02
TUBB2B -0.0010815 25766 GTEx DepMap Descartes 4.44 441.77


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 24428.64
Median rank of genes in gene set: 25021.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CDH13 0.0000239 8890 GTEx DepMap Descartes 0.10 4.31
NR5A2 -0.0002445 22687 GTEx DepMap Descartes 0.00 0.00
GALNT15 -0.0002831 23266 GTEx DepMap Descartes 0.01 NA
MYRIP -0.0002844 23291 GTEx DepMap Descartes 0.01 0.32
ESM1 -0.0002994 23467 GTEx DepMap Descartes 0.02 1.63
SHANK3 -0.0003149 23630 GTEx DepMap Descartes 0.14 5.27
SLCO2A1 -0.0003629 24085 GTEx DepMap Descartes 0.01 0.93
ID1 -0.0003941 24320 GTEx DepMap Descartes 1.37 229.82
DNASE1L3 -0.0003942 24321 GTEx DepMap Descartes 0.05 5.49
CRHBP -0.0003993 24358 GTEx DepMap Descartes 0.03 3.53
CHRM3 -0.0004016 24374 GTEx DepMap Descartes 0.01 0.34
APLNR -0.0004063 24413 GTEx DepMap Descartes 0.02 1.21
PODXL -0.0004132 24476 GTEx DepMap Descartes 0.08 3.00
FCGR2B -0.0004209 24545 GTEx DepMap Descartes 0.03 1.62
BTNL9 -0.0004233 24565 GTEx DepMap Descartes 0.06 4.54
NOTCH4 -0.0004334 24628 GTEx DepMap Descartes 0.09 3.09
SHE -0.0004486 24703 GTEx DepMap Descartes 0.01 0.31
CEACAM1 -0.0004511 24721 GTEx DepMap Descartes 0.02 1.78
FLT4 -0.0004544 24741 GTEx DepMap Descartes 0.02 1.20
IRX3 -0.0004855 24901 GTEx DepMap Descartes 0.01 1.09
CYP26B1 -0.0004886 24914 GTEx DepMap Descartes 0.05 2.62
TEK -0.0005085 25013 GTEx DepMap Descartes 0.03 1.75
NPR1 -0.0005134 25030 GTEx DepMap Descartes 0.03 1.87
TIE1 -0.0005203 25055 GTEx DepMap Descartes 0.03 1.15
RASIP1 -0.0005210 25058 GTEx DepMap Descartes 0.08 4.62
F8 -0.0005263 25088 GTEx DepMap Descartes 0.04 1.14
PTPRB -0.0005266 25089 GTEx DepMap Descartes 0.04 0.83
ROBO4 -0.0005346 25113 GTEx DepMap Descartes 0.02 1.12
EHD3 -0.0005503 25175 GTEx DepMap Descartes 0.11 6.39
MMRN2 -0.0005664 25234 GTEx DepMap Descartes 0.03 2.64


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 21238.61
Median rank of genes in gene set: 22710
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ZNF385D 0.0002050 4379 GTEx DepMap Descartes 0.07 1.62
GAS2 0.0001759 4849 GTEx DepMap Descartes 0.05 5.60
ABCC9 0.0001469 5374 GTEx DepMap Descartes 0.11 3.48
GLI2 0.0000766 6999 GTEx DepMap Descartes 0.05 1.87
DKK2 -0.0000853 17957 GTEx DepMap Descartes 0.02 0.99
CLDN11 -0.0001074 18981 GTEx DepMap Descartes 0.16 11.61
PCOLCE -0.0001131 19216 GTEx DepMap Descartes 0.34 50.63
ABCA6 -0.0001135 19236 GTEx DepMap Descartes 0.01 0.48
SCARA5 -0.0001197 19478 GTEx DepMap Descartes 0.01 0.52
ELN -0.0001270 19753 GTEx DepMap Descartes 0.14 10.08
CCDC102B -0.0001273 19766 GTEx DepMap Descartes 0.06 5.45
ITGA11 -0.0001403 20227 GTEx DepMap Descartes 0.01 0.22
ADAMTSL3 -0.0001510 20605 GTEx DepMap Descartes 0.01 0.20
BICC1 -0.0001751 21259 GTEx DepMap Descartes 0.11 4.49
FNDC1 -0.0001795 21381 GTEx DepMap Descartes 0.01 0.34
PAMR1 -0.0001913 21663 GTEx DepMap Descartes 0.02 0.90
POSTN -0.0001960 21750 GTEx DepMap Descartes 0.27 16.04
MXRA5 -0.0001980 21785 GTEx DepMap Descartes 0.02 0.27
LAMC3 -0.0002044 21920 GTEx DepMap Descartes 0.01 0.35
LUM -0.0002062 21963 GTEx DepMap Descartes 0.04 1.72
MGP -0.0002202 22265 GTEx DepMap Descartes 0.27 19.03
SFRP2 -0.0002379 22577 GTEx DepMap Descartes 0.08 3.28
LOX -0.0002398 22606 GTEx DepMap Descartes 0.03 1.09
PRICKLE1 -0.0002418 22644 GTEx DepMap Descartes 0.07 2.69
COL12A1 -0.0002464 22710 GTEx DepMap Descartes 0.21 3.31
ISLR -0.0002755 23159 GTEx DepMap Descartes 0.10 7.51
COL27A1 -0.0002869 23323 GTEx DepMap Descartes 0.03 0.70
HHIP -0.0002979 23449 GTEx DepMap Descartes 0.09 1.15
OGN -0.0003048 23533 GTEx DepMap Descartes 0.14 7.83
ACTA2 -0.0003078 23565 GTEx DepMap Descartes 0.05 7.55


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.26e-29
Mean rank of genes in gene set: 382.64
Median rank of genes in gene set: 89.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHGA 0.0176475 1 GTEx DepMap Descartes 94.32 11651.42
CHGB 0.0163608 2 GTEx DepMap Descartes 49.98 4972.72
SCG2 0.0147153 3 GTEx DepMap Descartes 12.62 1285.25
PENK 0.0132775 5 GTEx DepMap Descartes 8.46 1571.03
INSM1 0.0131589 6 GTEx DepMap Descartes 3.54 307.92
C1QL1 0.0126086 7 GTEx DepMap Descartes 4.41 675.65
HTATSF1 0.0108788 11 GTEx DepMap Descartes 8.81 746.65
SLC18A1 0.0107091 12 GTEx DepMap Descartes 3.69 355.15
PCSK1N 0.0102016 13 GTEx DepMap Descartes 14.78 3168.28
PNMT 0.0100336 14 GTEx DepMap Descartes 6.62 1387.62
ARC 0.0096922 15 GTEx DepMap Descartes 2.95 224.41
SLC24A2 0.0086225 19 GTEx DepMap Descartes 1.25 33.30
PCSK2 0.0072290 29 GTEx DepMap Descartes 1.40 82.06
DGKK 0.0069569 33 GTEx DepMap Descartes 1.07 37.75
CCSER1 0.0068894 37 GTEx DepMap Descartes 1.38 NA
ST18 0.0068163 38 GTEx DepMap Descartes 0.94 46.16
CNTN3 0.0056991 55 GTEx DepMap Descartes 0.60 36.24
FGF14 0.0056530 56 GTEx DepMap Descartes 1.26 26.60
GCH1 0.0055731 58 GTEx DepMap Descartes 1.41 112.35
SPOCK3 0.0052816 68 GTEx DepMap Descartes 0.79 62.78
KSR2 0.0051765 72 GTEx DepMap Descartes 0.48 7.83
FAM155A 0.0050121 77 GTEx DepMap Descartes 0.71 21.69
UNC80 0.0041988 102 GTEx DepMap Descartes 1.68 36.79
LINC00632 0.0040019 110 GTEx DepMap Descartes 1.05 NA
KCTD16 0.0035201 137 GTEx DepMap Descartes 0.42 8.16
AGBL4 0.0034482 140 GTEx DepMap Descartes 0.36 22.77
GALNTL6 0.0033449 148 GTEx DepMap Descartes 0.19 12.79
PACRG 0.0033355 149 GTEx DepMap Descartes 0.26 31.77
TMEM130 0.0032380 159 GTEx DepMap Descartes 0.38 26.03
MGAT4C 0.0031190 164 GTEx DepMap Descartes 0.71 6.80


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 23123.08
Median rank of genes in gene set: 24318
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HECTD4 0.0002127 4288 GTEx DepMap Descartes 0.53 NA
DENND4A 0.0000503 7891 GTEx DepMap Descartes 0.27 8.89
SLC25A21 -0.0000849 17924 GTEx DepMap Descartes 0.02 1.06
GCLC -0.0001025 18772 GTEx DepMap Descartes 0.20 13.48
RAPGEF2 -0.0001380 20152 GTEx DepMap Descartes 0.37 11.22
RHD -0.0001718 21168 GTEx DepMap Descartes 0.01 0.34
HBZ -0.0001945 21725 GTEx DepMap Descartes 0.78 201.68
RGS6 -0.0002061 21959 GTEx DepMap Descartes 0.00 0.04
TMCC2 -0.0002171 22198 GTEx DepMap Descartes 0.14 5.29
SPTB -0.0002198 22244 GTEx DepMap Descartes 0.09 2.97
ABCB10 -0.0002568 22873 GTEx DepMap Descartes 0.14 9.56
XPO7 -0.0002618 22955 GTEx DepMap Descartes 0.24 12.90
TMEM56 -0.0002657 23012 GTEx DepMap Descartes 0.14 NA
MICAL2 -0.0002698 23077 GTEx DepMap Descartes 0.03 0.57
RHCE -0.0002711 23097 GTEx DepMap Descartes 0.05 6.02
SNCA -0.0002759 23171 GTEx DepMap Descartes 0.94 66.16
TRAK2 -0.0002821 23248 GTEx DepMap Descartes 0.20 6.74
GYPE -0.0003039 23523 GTEx DepMap Descartes 0.01 0.22
EPB41 -0.0003059 23547 GTEx DepMap Descartes 0.55 23.32
TFR2 -0.0003139 23622 GTEx DepMap Descartes 0.03 1.32
SPTA1 -0.0003163 23646 GTEx DepMap Descartes 0.05 1.15
CR1L -0.0003360 23859 GTEx DepMap Descartes 0.01 0.99
ANK1 -0.0003739 24173 GTEx DepMap Descartes 0.04 1.32
SLC4A1 -0.0003761 24196 GTEx DepMap Descartes 0.11 3.15
RHAG -0.0004088 24440 GTEx DepMap Descartes 0.04 2.05
CPOX -0.0004129 24472 GTEx DepMap Descartes 0.16 14.68
TSPAN5 -0.0004505 24717 GTEx DepMap Descartes 0.18 10.05
FECH -0.0004515 24725 GTEx DepMap Descartes 0.20 5.67
EPB42 -0.0004720 24838 GTEx DepMap Descartes 0.04 1.77
HBG1 -0.0004738 24850 GTEx DepMap Descartes 3.39 367.19


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 21077.28
Median rank of genes in gene set: 22653.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SFMBT2 0.0003220 3122 GTEx DepMap Descartes 0.19 6.29
ITPR2 0.0001778 4820 GTEx DepMap Descartes 0.43 9.76
CST3 0.0001369 5563 GTEx DepMap Descartes 2.41 161.29
IFNGR1 0.0000513 7847 GTEx DepMap Descartes 0.36 36.28
HRH1 -0.0000285 13093 GTEx DepMap Descartes 0.13 5.59
MS4A4E -0.0000597 16221 GTEx DepMap Descartes 0.00 0.00
RBPJ -0.0000852 17943 GTEx DepMap Descartes 1.34 54.60
SPP1 -0.0001288 19833 GTEx DepMap Descartes 0.03 3.32
CD163L1 -0.0001481 20515 GTEx DepMap Descartes 0.01 0.41
HCK -0.0001505 20588 GTEx DepMap Descartes 0.01 0.75
LGMN -0.0001693 21112 GTEx DepMap Descartes 0.37 43.28
CD14 -0.0001764 21305 GTEx DepMap Descartes 0.11 10.62
FGD2 -0.0001780 21341 GTEx DepMap Descartes 0.01 0.45
ATP8B4 -0.0001937 21700 GTEx DepMap Descartes 0.01 0.24
MSR1 -0.0001956 21743 GTEx DepMap Descartes 0.01 0.43
MS4A4A -0.0002050 21928 GTEx DepMap Descartes 0.02 1.53
ADAP2 -0.0002052 21933 GTEx DepMap Descartes 0.03 2.37
VSIG4 -0.0002090 22028 GTEx DepMap Descartes 0.01 1.21
MPEG1 -0.0002106 22064 GTEx DepMap Descartes 0.02 0.69
SLCO2B1 -0.0002121 22089 GTEx DepMap Descartes 0.01 0.26
HLA-DPA1 -0.0002197 22241 GTEx DepMap Descartes 0.06 2.39
CTSD -0.0002206 22276 GTEx DepMap Descartes 0.87 106.13
MARCH1 -0.0002218 22299 GTEx DepMap Descartes 0.02 NA
CD163 -0.0002296 22439 GTEx DepMap Descartes 0.04 1.81
MS4A7 -0.0002422 22650 GTEx DepMap Descartes 0.03 1.78
C1QB -0.0002427 22657 GTEx DepMap Descartes 0.06 13.55
CYBB -0.0002436 22671 GTEx DepMap Descartes 0.04 2.18
C1QC -0.0002464 22712 GTEx DepMap Descartes 0.04 4.85
CTSS -0.0002476 22731 GTEx DepMap Descartes 0.02 1.03
C1QA -0.0002568 22874 GTEx DepMap Descartes 0.09 17.70


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 16043.84
Median rank of genes in gene set: 22504
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NRXN3 0.0020236 341 GTEx DepMap Descartes 0.34 11.36
SORCS1 0.0019436 373 GTEx DepMap Descartes 0.30 11.48
EGFLAM 0.0015728 511 GTEx DepMap Descartes 0.36 21.57
NRXN1 0.0015625 517 GTEx DepMap Descartes 1.23 37.60
PTN 0.0014221 590 GTEx DepMap Descartes 2.87 387.86
GRIK3 0.0011104 837 GTEx DepMap Descartes 0.13 3.79
LRRTM4 0.0007224 1437 GTEx DepMap Descartes 0.07 5.13
GAS7 0.0006573 1588 GTEx DepMap Descartes 0.28 9.30
PAG1 0.0005474 1923 GTEx DepMap Descartes 0.90 23.77
GFRA3 0.0002051 4376 GTEx DepMap Descartes 0.43 56.71
COL18A1 0.0001772 4830 GTEx DepMap Descartes 0.63 29.16
IL1RAPL2 0.0001461 5394 GTEx DepMap Descartes 0.01 1.52
MDGA2 0.0000938 6522 GTEx DepMap Descartes 0.02 0.99
SCN7A 0.0000917 6578 GTEx DepMap Descartes 0.15 4.48
SOX5 0.0000915 6588 GTEx DepMap Descartes 0.22 7.46
FIGN 0.0000496 7914 GTEx DepMap Descartes 0.17 4.94
DST 0.0000399 8261 GTEx DepMap Descartes 2.94 37.77
NLGN4X 0.0000214 8995 GTEx DepMap Descartes 0.24 12.43
STARD13 -0.0000191 11801 GTEx DepMap Descartes 0.14 5.79
TRPM3 -0.0000758 17356 GTEx DepMap Descartes 0.09 2.00
ERBB4 -0.0000946 18415 GTEx DepMap Descartes 0.03 1.26
COL25A1 -0.0001312 19925 GTEx DepMap Descartes 0.08 2.49
ZNF536 -0.0002251 22364 GTEx DepMap Descartes 0.11 5.75
SOX10 -0.0002315 22471 GTEx DepMap Descartes 0.02 1.56
CDH19 -0.0002336 22504 GTEx DepMap Descartes 0.02 0.90
IL1RAPL1 -0.0002346 22519 GTEx DepMap Descartes 0.00 0.37
LAMC1 -0.0002504 22777 GTEx DepMap Descartes 0.32 10.97
MPZ -0.0002507 22785 GTEx DepMap Descartes 0.05 4.97
ADAMTS5 -0.0002637 22984 GTEx DepMap Descartes 0.02 0.35
PLCE1 -0.0002664 23027 GTEx DepMap Descartes 0.06 0.92


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 20545.02
Median rank of genes in gene set: 22740
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD9 0.0011898 764 GTEx DepMap Descartes 1.74 229.20
RAB27B 0.0009530 1021 GTEx DepMap Descartes 0.41 15.12
ACTN1 0.0007029 1474 GTEx DepMap Descartes 0.61 33.02
ANGPT1 0.0001513 5285 GTEx DepMap Descartes 0.22 13.73
SLC2A3 0.0000498 7906 GTEx DepMap Descartes 1.11 64.28
PDE3A -0.0000491 15343 GTEx DepMap Descartes 0.17 6.06
PPBP -0.0000710 17050 GTEx DepMap Descartes 0.01 1.33
PF4 -0.0000726 17142 GTEx DepMap Descartes 0.01 2.17
ITGA2B -0.0000726 17144 GTEx DepMap Descartes 0.01 1.16
ITGB3 -0.0000805 17634 GTEx DepMap Descartes 0.00 0.06
SLC24A3 -0.0001027 18790 GTEx DepMap Descartes 0.01 0.79
GP1BA -0.0001036 18827 GTEx DepMap Descartes 0.00 0.00
TUBB1 -0.0001144 19271 GTEx DepMap Descartes 0.04 4.23
STON2 -0.0001173 19387 GTEx DepMap Descartes 0.11 6.49
GP9 -0.0001362 20096 GTEx DepMap Descartes 0.00 0.00
TRPC6 -0.0001597 20864 GTEx DepMap Descartes 0.00 0.23
P2RX1 -0.0001710 21150 GTEx DepMap Descartes 0.00 0.07
CD84 -0.0001800 21399 GTEx DepMap Descartes 0.00 0.04
MCTP1 -0.0001933 21694 GTEx DepMap Descartes 0.00 0.08
PLEK -0.0001979 21783 GTEx DepMap Descartes 0.01 1.18
BIN2 -0.0002097 22039 GTEx DepMap Descartes 0.01 1.28
FERMT3 -0.0002346 22518 GTEx DepMap Descartes 0.01 1.47
SPN -0.0002407 22625 GTEx DepMap Descartes 0.01 0.29
MED12L -0.0002472 22725 GTEx DepMap Descartes 0.11 3.20
MYLK -0.0002482 22740 GTEx DepMap Descartes 0.13 3.66
THBS1 -0.0002795 23221 GTEx DepMap Descartes 0.04 1.07
HIPK2 -0.0002801 23226 GTEx DepMap Descartes 0.43 7.25
UBASH3B -0.0002837 23277 GTEx DepMap Descartes 0.01 0.50
ARHGAP6 -0.0002983 23457 GTEx DepMap Descartes 0.01 0.31
PSTPIP2 -0.0003017 23500 GTEx DepMap Descartes 0.02 1.30


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 19213.94
Median rank of genes in gene set: 23690
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD44 0.0026138 217 GTEx DepMap Descartes 2.07 95.74
SCML4 0.0018243 411 GTEx DepMap Descartes 0.20 12.91
RAP1GAP2 0.0012532 715 GTEx DepMap Descartes 0.23 9.41
DOCK10 0.0007133 1455 GTEx DepMap Descartes 0.27 11.95
SORL1 0.0006295 1647 GTEx DepMap Descartes 0.42 12.23
ABLIM1 0.0001279 5725 GTEx DepMap Descartes 0.35 12.80
CELF2 0.0001104 6123 GTEx DepMap Descartes 0.26 8.19
EVL 0.0000952 6489 GTEx DepMap Descartes 1.20 85.44
ANKRD44 0.0000487 7949 GTEx DepMap Descartes 0.29 10.55
WIPF1 0.0000020 9823 GTEx DepMap Descartes 0.17 9.83
PITPNC1 -0.0000155 11288 GTEx DepMap Descartes 0.23 8.42
LCP1 -0.0000304 13349 GTEx DepMap Descartes 0.12 7.81
STK39 -0.0000410 14572 GTEx DepMap Descartes 0.27 19.40
LINC00299 -0.0001225 19589 GTEx DepMap Descartes 0.00 0.00
CCL5 -0.0001414 20262 GTEx DepMap Descartes 0.02 3.43
SKAP1 -0.0001493 20553 GTEx DepMap Descartes 0.02 1.67
FYN -0.0001630 20956 GTEx DepMap Descartes 0.71 49.11
NKG7 -0.0001790 21363 GTEx DepMap Descartes 0.02 8.88
ARHGAP15 -0.0002442 22681 GTEx DepMap Descartes 0.01 1.04
NCALD -0.0002605 22933 GTEx DepMap Descartes 0.18 9.63
SAMD3 -0.0002660 23013 GTEx DepMap Descartes 0.01 0.49
PTPRC -0.0003043 23526 GTEx DepMap Descartes 0.03 1.19
PLEKHA2 -0.0003154 23634 GTEx DepMap Descartes 0.04 1.99
IKZF1 -0.0003194 23679 GTEx DepMap Descartes 0.01 0.26
MCTP2 -0.0003210 23701 GTEx DepMap Descartes 0.02 0.33
ITPKB -0.0003273 23766 GTEx DepMap Descartes 0.02 0.62
PDE3B -0.0003478 23978 GTEx DepMap Descartes 0.07 2.89
RCSD1 -0.0003521 24015 GTEx DepMap Descartes 0.01 0.39
HLA-C -0.0003628 24084 GTEx DepMap Descartes 0.63 73.06
PRKCH -0.0004041 24391 GTEx DepMap Descartes 0.02 0.85


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Granulocytes: Neutrophils (model markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.91e-02
Mean rank of genes in gene set: 4760.33
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GATA3-AS1 0.0019434 374 GTEx DepMap Descartes 0.58 NA
OR2A25 0.0000882 6657 GTEx DepMap Descartes 0.00 0.34
LINC01709 0.0000694 7250 GTEx DepMap Descartes 0.00 NA


No detectable expression in this dataset: IGHV5-78

Macrophages: Hofbauer cells (model markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.30e-02
Mean rank of genes in gene set: 8641.44
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GATA3-AS1 0.0019434 374 GTEx DepMap Descartes 0.58 NA
CGA 0.0007623 1355 GTEx DepMap Descartes 0.06 18.21
PANX2 0.0006256 1660 GTEx DepMap Descartes 0.09 8.48
PAGE4 0.0001826 4742 GTEx DepMap Descartes 0.02 1.68
ZFHX4-AS1 0.0000867 6709 GTEx DepMap Descartes 0.01 NA
KIAA0087 0.0000133 9319 GTEx DepMap Descartes 0.00 0.00
XAGE3 -0.0000268 12872 GTEx DepMap Descartes 0.00 0.00
GAPLINC -0.0000484 15285 GTEx DepMap Descartes 0.00 NA
LYVE1 -0.0006577 25457 GTEx DepMap Descartes 0.17 10.44


Plasma cells: Plasma cells (model markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.11e-02
Mean rank of genes in gene set: 9149.86
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ST18 0.0068163 38 GTEx DepMap Descartes 0.94 46.16
TGFBR3L 0.0019663 366 GTEx DepMap Descartes 0.14 NA
XBP1 0.0005927 1766 GTEx DepMap Descartes 0.84 84.88
IGKC -0.0000355 13944 GTEx DepMap Descartes 0.00 0.00
JCHAIN -0.0000416 14631 GTEx DepMap Descartes 0.00 NA
MZB1 -0.0000620 16395 GTEx DepMap Descartes 0.00 NA
C11orf72 -0.0000690 16909 GTEx DepMap Descartes 0.00 0.00