Program: 3. Translation (Activity Program).

Program: 3. Translation (Activity Program).



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 EEF1A1 0.0106823 eukaryotic translation elongation factor 1 alpha 1 GTEx DepMap Descartes 86.72 5038.01
2 RPL13 0.0089587 ribosomal protein L13 GTEx DepMap Descartes 78.89 4762.46
3 RPSA 0.0072813 ribosomal protein SA GTEx DepMap Descartes 22.31 2626.83
4 EIF3E 0.0072348 eukaryotic translation initiation factor 3 subunit E GTEx DepMap Descartes 4.20 523.24
5 PABPC1 0.0068550 poly(A) binding protein cytoplasmic 1 GTEx DepMap Descartes 7.06 687.55
6 EEF2 0.0063330 eukaryotic translation elongation factor 2 GTEx DepMap Descartes 10.43 747.45
7 TPT1 0.0057085 tumor protein, translationally-controlled 1 GTEx DepMap Descartes 38.23 2322.34
8 TOMM7 0.0052509 translocase of outer mitochondrial membrane 7 GTEx DepMap Descartes 5.01 1761.44
9 COX7C 0.0050795 cytochrome c oxidase subunit 7C GTEx DepMap Descartes 9.08 1350.54
10 HNRNPA1 0.0049304 heterogeneous nuclear ribonucleoprotein A1 GTEx DepMap Descartes 12.23 653.30
11 EEF1D 0.0047354 eukaryotic translation elongation factor 1 delta GTEx DepMap Descartes 7.01 584.74
12 PFDN5 0.0044662 prefoldin subunit 5 GTEx DepMap Descartes 8.82 1110.39
13 TMSB4X 0.0044288 thymosin beta 4 X-linked GTEx DepMap Descartes 86.88 14274.19
14 EIF3L 0.0043609 eukaryotic translation initiation factor 3 subunit L GTEx DepMap Descartes 4.24 263.92
15 FXYD5 0.0042855 FXYD domain containing ion transport regulator 5 GTEx DepMap Descartes 2.11 446.38
16 UQCRB 0.0042468 ubiquinol-cytochrome c reductase binding protein GTEx DepMap Descartes 5.21 152.77
17 COMMD6 0.0042141 COMM domain containing 6 GTEx DepMap Descartes 4.92 690.65
18 RPL18 0.0040579 ribosomal protein L18 GTEx DepMap Descartes 27.98 1868.19
19 CCR7 0.0039314 C-C motif chemokine receptor 7 GTEx DepMap Descartes 1.13 176.38
20 EIF3H 0.0037740 eukaryotic translation initiation factor 3 subunit H GTEx DepMap Descartes 3.07 189.36
21 CD52 0.0036936 CD52 molecule GTEx DepMap Descartes 5.11 3009.70
22 ARHGDIB 0.0034273 Rho GDP dissociation inhibitor beta GTEx DepMap Descartes 3.84 1050.64
23 COX4I1 0.0034254 cytochrome c oxidase subunit 4I1 GTEx DepMap Descartes 7.10 455.26
24 ARID5A 0.0032973 AT-rich interaction domain 5A GTEx DepMap Descartes 0.46 55.40
25 CIRBP 0.0032095 cold inducible RNA binding protein GTEx DepMap Descartes 5.21 284.71
26 PLAC8 0.0031830 placenta associated 8 GTEx DepMap Descartes 0.84 123.59
27 CREM 0.0031153 cAMP responsive element modulator GTEx DepMap Descartes 1.76 265.24
28 NBEAL1 0.0030343 neurobeachin like 1 GTEx DepMap Descartes 0.60 14.00
29 LTB 0.0030102 lymphotoxin beta GTEx DepMap Descartes 8.52 2021.08
30 CD7 0.0030089 CD7 molecule GTEx DepMap Descartes 2.23 399.72
31 SELL 0.0029603 selectin L GTEx DepMap Descartes 0.73 103.10
32 GYPC 0.0029343 glycophorin C (Gerbich blood group) GTEx DepMap Descartes 1.38 264.53
33 LEF1 0.0028812 lymphoid enhancer binding factor 1 GTEx DepMap Descartes 0.53 52.78
34 EIF3F 0.0028574 eukaryotic translation initiation factor 3 subunit F GTEx DepMap Descartes 2.97 96.13
35 NAP1L1 0.0028470 nucleosome assembly protein 1 like 1 GTEx DepMap Descartes 4.43 74.34
36 GPSM3 0.0027909 G protein signaling modulator 3 GTEx DepMap Descartes 1.35 314.66
37 FBL 0.0027392 fibrillarin GTEx DepMap Descartes 0.97 178.53
38 LYPD3 0.0027368 LY6/PLAUR domain containing 3 GTEx DepMap Descartes 0.26 60.09
39 EIF4A2 0.0027188 eukaryotic translation initiation factor 4A2 GTEx DepMap Descartes 3.98 154.61
40 UXT 0.0027043 ubiquitously expressed prefoldin like chaperone GTEx DepMap Descartes 1.78 570.76
41 TMSB10 0.0026977 thymosin beta 10 GTEx DepMap Descartes 49.95 24434.33
42 ARPC1B 0.0026768 actin related protein ⅔ complex subunit 1B GTEx DepMap Descartes 1.94 303.30
43 PFN1 0.0026681 profilin 1 GTEx DepMap Descartes 10.09 2381.94
44 SNRPD2 0.0026083 small nuclear ribonucleoprotein D2 polypeptide GTEx DepMap Descartes 3.22 923.64
45 CORO1A 0.0026060 coronin 1A GTEx DepMap Descartes 2.74 300.75
46 ALDOA 0.0025708 aldolase, fructose-bisphosphate A GTEx DepMap Descartes 2.78 172.76
47 BTG1 0.0025014 BTG anti-proliferation factor 1 GTEx DepMap Descartes 8.63 644.16
48 OST4 0.0025002 oligosaccharyltransferase complex subunit 4, non-catalytic GTEx DepMap Descartes 4.17 1900.18
49 RGCC 0.0024467 regulator of cell cycle GTEx DepMap Descartes 2.73 NA
50 OXA1L 0.0024082 OXA1L mitochondrial inner membrane protein GTEx DepMap Descartes 0.58 46.81


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UMAP plots showing activity of gene expression program identified in GEP 3. Translation (Activity Program):

Interactive UMAP Plot
Interactive UMAP Plot
Interactive Boxplot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
RUBENSTEIN_SKELETAL_MUSCLE_T_CELLS 9.08e-46 135.69 72.54 6.09e-43 6.09e-43
31EEF1A1, RPL13, RPSA, EIF3E, PABPC1, TPT1, TOMM7, COX7C, HNRNPA1, EEF1D, PFDN5, TMSB4X, EIF3L, FXYD5, UQCRB, COMMD6, RPL18, EIF3H, CD52, ARHGDIB, PLAC8, LTB, CD7, SELL, EIF3F, UXT, ARPC1B, PFN1, CORO1A, BTG1, OST4
 181
RUBENSTEIN_SKELETAL_MUSCLE_SATELLITE_CELLS 5.86e-23 34.09 18.35 1.31e-20 3.93e-20
22EEF1A1, RPL13, RPSA, EIF3E, PABPC1, EEF2, TPT1, TOMM7, HNRNPA1, EEF1D, EIF3L, UQCRB, COMMD6, RPL18, EIF3H, COX4I1, CIRBP, EIF3F, EIF4A2, UXT, SNRPD2, ALDOA
 310
FAN_OVARY_CL12_T_LYMPHOCYTE_NK_CELL_2 2.75e-17 36.67 18.20 2.63e-15 1.84e-14
15PABPC1, TPT1, TMSB4X, FXYD5, CD52, ARHGDIB, CREM, LTB, CD7, ARPC1B, PFN1, CORO1A, BTG1, OST4, RGCC
 161
HAY_BONE_MARROW_NAIVE_T_CELL 6.26e-25 33.07 18.04 2.10e-22 4.20e-22
25EEF1A1, RPL13, RPSA, EIF3E, PABPC1, TPT1, TOMM7, COX7C, EEF1D, FXYD5, COMMD6, RPL18, CCR7, EIF3H, ARID5A, CREM, NBEAL1, LTB, LEF1, GPSM3, LYPD3, EIF4A2, SNRPD2, BTG1, RGCC
 403
CUI_DEVELOPING_HEART_C9_B_T_CELL 5.74e-16 34.45 16.78 4.81e-14 3.85e-13
14PABPC1, FXYD5, CD52, ARHGDIB, PLAC8, LTB, CD7, SELL, LEF1, GPSM3, ARPC1B, CORO1A, BTG1, RGCC
 155
RUBENSTEIN_SKELETAL_MUSCLE_MYELOID_CELLS 6.62e-22 30.24 16.29 1.11e-19 4.44e-19
22EEF1A1, EIF3E, PABPC1, COX7C, PFDN5, TMSB4X, EIF3L, FXYD5, COMMD6, CD52, ARHGDIB, COX4I1, PLAC8, EIF3F, NAP1L1, GPSM3, TMSB10, ARPC1B, PFN1, CORO1A, ALDOA, OST4
 347
ZHENG_CORD_BLOOD_C8_PUTATIVE_LYMPHOID_PRIMED_MULTIPOTENT_PROGENITOR_2 3.50e-12 35.87 15.49 1.24e-10 2.35e-09
10TPT1, HNRNPA1, PFDN5, TMSB4X, COMMD6, CD52, SELL, GYPC, NAP1L1, SNRPD2
 97
RUBENSTEIN_SKELETAL_MUSCLE_B_CELLS 3.66e-15 29.80 14.56 2.05e-13 2.46e-12
14EEF1A1, RPL13, RPSA, PABPC1, COX7C, EEF1D, PFDN5, RPL18, CD52, PLAC8, LTB, SELL, EIF4A2, BTG1
 177
FAN_EMBRYONIC_CTX_BRAIN_NAIVE_LIKE_T_CELL 2.46e-14 30.26 14.45 1.27e-12 1.65e-11
13EEF1D, FXYD5, CCR7, CD52, ARHGDIB, PLAC8, LTB, CD7, SELL, LEF1, GPSM3, CORO1A, RGCC
 158
FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_IMMUNE 3.33e-13 28.99 13.49 1.31e-11 2.23e-10
12EEF1D, FXYD5, CD52, ARHGDIB, PLAC8, LTB, CD7, SELL, GPSM3, ARPC1B, PFN1, CORO1A
 148
DESCARTES_FETAL_STOMACH_LYMPHOID_CELLS 9.58e-10 32.13 12.59 2.07e-08 6.43e-07
8CCR7, CD52, LTB, CD7, SELL, LEF1, GPSM3, CORO1A
 82
MENON_FETAL_KIDNEY_10_IMMUNE_CELLS 1.06e-09 31.71 12.43 2.22e-08 7.09e-07
8PABPC1, TPT1, TMSB4X, ARHGDIB, TMSB10, ARPC1B, PFN1, CORO1A
 83
LAKE_ADULT_KIDNEY_C9_THIN_ASCENDING_LIMB 2.23e-15 23.34 11.87 1.49e-13 1.49e-12
16EEF1A1, RPL13, RPSA, PABPC1, EEF2, TPT1, COX7C, EEF1D, PFDN5, RPL18, COX4I1, CIRBP, NAP1L1, EIF4A2, ALDOA, BTG1
 268
TRAVAGLINI_LUNG_PROXIMAL_BASAL_CELL 2.41e-20 20.72 11.34 3.23e-18 1.62e-17
25EEF1A1, RPL13, RPSA, EIF3E, PABPC1, EEF2, TPT1, HNRNPA1, EEF1D, EIF3L, UQCRB, COMMD6, RPL18, EIF3H, COX4I1, CIRBP, GYPC, EIF3F, NAP1L1, FBL, EIF4A2, UXT, SNRPD2, ALDOA, OXA1L
 629
RUBENSTEIN_SKELETAL_MUSCLE_NK_CELLS 1.05e-13 22.94 11.25 4.69e-12 7.04e-11
14RPSA, PABPC1, HNRNPA1, TMSB4X, CD52, ARHGDIB, PLAC8, CD7, GPSM3, ARPC1B, PFN1, CORO1A, BTG1, OST4
 226
LAKE_ADULT_KIDNEY_C18_COLLECTING_DUCT_PRINCIPAL_CELLS_MEDULLA 1.81e-15 21.12 10.91 1.35e-13 1.21e-12
17EEF1A1, RPL13, RPSA, PABPC1, EEF2, TPT1, COX7C, EEF1D, PFDN5, TMSB4X, RPL18, COX4I1, CREM, NAP1L1, EIF4A2, TMSB10, ALDOA
 322
LAKE_ADULT_KIDNEY_C7_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S3 9.53e-11 24.98 10.89 2.37e-09 6.40e-08
10EEF1A1, RPL13, RPSA, PABPC1, EEF2, TPT1, COX7C, RPL18, COX4I1, TMSB10
 135
FAN_OVARY_CL2_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_1 4.00e-09 26.41 10.42 7.66e-08 2.68e-06
8TOMM7, PFDN5, UQCRB, COMMD6, CIRBP, NBEAL1, SNRPD2, OST4
 98
MANNO_MIDBRAIN_NEUROTYPES_BASAL 2.30e-08 28.24 10.37 4.17e-07 1.54e-05
7EEF1A1, RPL13, EEF2, PFDN5, UQCRB, COX4I1, EIF4A2
 79
LAKE_ADULT_KIDNEY_C8_DECENDING_THIN_LIMB 8.56e-14 20.37 10.20 4.10e-12 5.74e-11
15EEF1A1, RPL13, RPSA, PABPC1, EEF2, TPT1, EEF1D, PFDN5, RPL18, CIRBP, NAP1L1, EIF4A2, TMSB10, ALDOA, BTG1
 278

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_MYC_TARGETS_V1 1.24e-04 8.78 3.02 6.18e-03 6.18e-03
6PABPC1, HNRNPA1, RPL18, NAP1L1, FBL, SNRPD2
 200
HALLMARK_OXIDATIVE_PHOSPHORYLATION 7.71e-03 5.55 1.44 1.93e-01 3.85e-01
4COX7C, UQCRB, COX4I1, OXA1L
 200
HALLMARK_HYPOXIA 4.35e-02 4.05 0.80 7.25e-01 1.00e+00
3PLAC8, ALDOA, BTG1
 200
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 7.33e-02 4.69 0.55 7.70e-01 1.00e+00
2EEF2, EIF4A2
 113
HALLMARK_UV_RESPONSE_UP 1.28e-01 3.34 0.39 7.70e-01 1.00e+00
2ALDOA, BTG1
 158
HALLMARK_IL2_STAT5_SIGNALING 1.83e-01 2.64 0.31 7.70e-01 1.00e+00
2LTB, SELL
 199
HALLMARK_MTORC1_SIGNALING 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2CORO1A, ALDOA
 200
HALLMARK_INFLAMMATORY_RESPONSE 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2CCR7, SELL
 200
HALLMARK_P53_PATHWAY 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2RPL18, BTG1
 200
HALLMARK_ALLOGRAFT_REJECTION 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2LTB, CD7
 200
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.54e-01 6.22 0.15 7.70e-01 1.00e+00
1LEF1
 42
HALLMARK_APICAL_SURFACE 1.61e-01 5.93 0.14 7.70e-01 1.00e+00
1LYPD3
 44
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 9.12e-01 1.00e+00
1LTB
 87
HALLMARK_INTERFERON_ALPHA_RESPONSE 3.20e-01 2.66 0.07 9.12e-01 1.00e+00
1SELL
 97
HALLMARK_PEROXISOME 3.39e-01 2.48 0.06 9.12e-01 1.00e+00
1PABPC1
 104
HALLMARK_PI3K_AKT_MTOR_SIGNALING 3.41e-01 2.45 0.06 9.12e-01 1.00e+00
1PFN1
 105
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 9.12e-01 1.00e+00
1ALDOA
 158
HALLMARK_APOPTOSIS 4.72e-01 1.59 0.04 9.12e-01 1.00e+00
1LEF1
 161
HALLMARK_MITOTIC_SPINDLE 5.45e-01 1.29 0.03 9.12e-01 1.00e+00
1UXT
 199
HALLMARK_TNFA_SIGNALING_VIA_NFKB 5.47e-01 1.28 0.03 9.12e-01 1.00e+00
1BTG1
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_CARDIAC_MUSCLE_CONTRACTION 3.74e-03 10.49 2.04 4.70e-01 6.95e-01
3COX7C, UQCRB, COX4I1
 79
KEGG_RIBOSOME 5.05e-03 9.38 1.83 4.70e-01 9.39e-01
3RPL13, RPSA, RPL18
 88
KEGG_PARKINSONS_DISEASE 1.45e-02 6.28 1.23 7.04e-01 1.00e+00
3COX7C, UQCRB, COX4I1
 130
KEGG_OXIDATIVE_PHOSPHORYLATION 1.51e-02 6.18 1.22 7.04e-01 1.00e+00
3COX7C, UQCRB, COX4I1
 132
KEGG_ALZHEIMERS_DISEASE 2.74e-02 4.89 0.96 1.00e+00 1.00e+00
3COX7C, UQCRB, COX4I1
 166
KEGG_HUNTINGTONS_DISEASE 3.45e-02 4.46 0.88 1.00e+00 1.00e+00
3COX7C, UQCRB, COX4I1
 182
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.07e-02 3.80 0.75 1.00e+00 1.00e+00
3TMSB4X, ARPC1B, PFN1
 213
KEGG_SPLICEOSOME 8.94e-02 4.17 0.49 1.00e+00 1.00e+00
2HNRNPA1, SNRPD2
 127
KEGG_PROTEIN_EXPORT 9.13e-02 11.08 0.26 1.00e+00 1.00e+00
1OXA1L
 24
KEGG_PENTOSE_PHOSPHATE_PATHWAY 1.02e-01 9.80 0.23 1.00e+00 1.00e+00
1ALDOA
 27
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 2.77e-01 1.98 0.23 1.00e+00 1.00e+00
2CCR7, LTB
 265
KEGG_THYROID_CANCER 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1LEF1
 29
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 1.27e-01 7.73 0.19 1.00e+00 1.00e+00
1ALDOA
 34
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1ARHGDIB
 44
KEGG_ENDOMETRIAL_CANCER 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1LEF1
 52
KEGG_BASAL_CELL_CARCINOMA 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1LEF1
 55
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1ARPC1B
 56
KEGG_ACUTE_MYELOID_LEUKEMIA 2.03e-01 4.55 0.11 1.00e+00 1.00e+00
1LEF1
 57
KEGG_GLYCOLYSIS_GLUCONEOGENESIS 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1ALDOA
 62
KEGG_COLORECTAL_CANCER 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1LEF1
 62

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr12q21 9.06e-02 4.13 0.48 1.00e+00 1.00e+00
2NAP1L1, BTG1
 128
chr16q24 9.30e-02 4.07 0.47 1.00e+00 1.00e+00
2RPL13, COX4I1
 130
chr8q22 1.22e-01 3.45 0.40 1.00e+00 1.00e+00
2PABPC1, UQCRB
 153
chr19q13 6.12e-01 1.20 0.37 1.00e+00 1.00e+00
5FXYD5, RPL18, FBL, LYPD3, SNRPD2
 1165
chr13q14 2.41e-01 2.19 0.26 1.00e+00 1.00e+00
2TPT1, RGCC
 240
chr16p11 2.74e-01 2.00 0.23 1.00e+00 1.00e+00
2CORO1A, ALDOA
 263
chr8q24 3.56e-01 1.63 0.19 1.00e+00 1.00e+00
2EEF1D, EIF3H
 321
chr12q13 6.71e-01 1.29 0.15 1.00e+00 1.00e+00
2HNRNPA1, PFDN5
 407
chr8q23 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1EIF3E
 44
chr6p21 7.00e-01 1.12 0.13 1.00e+00 1.00e+00
2LTB, GPSM3
 467
chr6q13 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1EEF1A1
 56
chr13q22 2.16e-01 4.25 0.10 1.00e+00 1.00e+00
1COMMD6
 61
chr19p13 1.00e+00 0.68 0.08 1.00e+00 1.00e+00
2EEF2, CIRBP
 773
chr4q25 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1LEF1
 87
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1TOMM7
 96
chr12p12 3.46e-01 2.41 0.06 1.00e+00 1.00e+00
1ARHGDIB
 107
chr3q27 3.67e-01 2.24 0.06 1.00e+00 1.00e+00
1EIF4A2
 115
chr1q24 3.87e-01 2.09 0.05 1.00e+00 1.00e+00
1SELL
 123
chr5q14 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1COX7C
 130
chr2p23 4.38e-01 1.77 0.04 1.00e+00 1.00e+00
1OST4
 145

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GTF2A2_TARGET_GENES 5.18e-08 8.63 4.18 5.86e-05 5.86e-05
13EEF1A1, RPL13, RPSA, PABPC1, EEF2, HNRNPA1, EEF1D, TMSB4X, RPL18, CIRBP, EIF4A2, TMSB10, BTG1
 522
PSMB5_TARGET_GENES 2.38e-06 9.21 3.90 1.35e-03 2.70e-03
9EEF1A1, RPSA, PABPC1, EEF2, TMSB4X, CIRBP, EIF4A2, TMSB10, ALDOA
 307
ZFHX3_TARGET_GENES 6.46e-06 4.17 2.22 2.44e-03 7.32e-03
19EEF1A1, EIF3E, PABPC1, TPT1, TOMM7, COX7C, HNRNPA1, EEF1D, PFDN5, FXYD5, UQCRB, COMMD6, RPL18, ARHGDIB, COX4I1, PLAC8, EIF3F, EIF4A2, ALDOA
 1857
SETD7_TARGET_GENES 4.43e-05 4.49 2.18 1.26e-02 5.02e-02
13EEF1A1, RPL13, TPT1, HNRNPA1, EEF1D, TMSB4X, COX4I1, CIRBP, CREM, NAP1L1, EIF4A2, ARPC1B, ALDOA
 991
PER1_TARGET_GENES 7.55e-03 16.78 1.89 9.97e-01 1.00e+00
2EEF1A1, EIF4A2
 33
SNRNP70_TARGET_GENES 9.26e-04 3.53 1.63 2.10e-01 1.00e+00
11EEF1A1, RPL13, EEF2, HNRNPA1, EEF1D, RPL18, SELL, NAP1L1, EIF4A2, ARPC1B, PFN1
 1009
THRA_TARGET_GENES 9.30e-03 7.45 1.46 9.97e-01 1.00e+00
3EIF3E, EEF2, OXA1L
 110
FOXE1_TARGET_GENES 5.45e-03 3.31 1.34 9.41e-01 1.00e+00
8RPL13, PABPC1, EEF2, COX7C, HNRNPA1, COMMD6, RPL18, EIF4A2
 728
CRGAARNNNNCGA_UNKNOWN 1.55e-02 11.31 1.29 9.97e-01 1.00e+00
2TPT1, LEF1
 48
MORC2_TARGET_GENES 5.81e-03 2.51 1.25 9.41e-01 1.00e+00
14EEF1A1, RPL13, RPSA, EIF3E, EEF2, TOMM7, HNRNPA1, EEF1D, TMSB4X, COX4I1, CIRBP, CREM, EIF3F, BTG1
 1954
SQSTM1_TARGET_GENES 1.74e-02 10.62 1.22 9.97e-01 1.00e+00
2EEF1A1, EEF1D
 51
HOXA2_TARGET_GENES 1.06e-02 2.51 1.19 9.97e-01 1.00e+00
12EEF1A1, TOMM7, COX7C, HNRNPA1, UQCRB, COMMD6, RPL18, EIF3H, EIF3F, FBL, UXT, OXA1L
 1586
ZMYND11_TARGET_GENES 1.87e-02 10.20 1.17 9.97e-01 1.00e+00
2RPL13, EEF1D
 53
NFRKB_TARGET_GENES 9.74e-03 2.40 1.17 9.97e-01 1.00e+00
13EIF3E, COX7C, HNRNPA1, EEF1D, PFDN5, EIF3L, EIF3H, EIF3F, EIF4A2, SNRPD2, CORO1A, ALDOA, OXA1L
 1843
HOXC11_TARGET_GENES 1.94e-02 10.01 1.15 9.97e-01 1.00e+00
2EEF1A1, GPSM3
 54
ETS_Q4 1.66e-02 4.38 1.14 9.97e-01 1.00e+00
4FXYD5, UXT, ARPC1B, CORO1A
 252
GUCY1B1_TARGET_GENES 1.40e-02 3.00 1.13 9.97e-01 1.00e+00
7EEF2, TOMM7, EEF1D, COMMD6, COX4I1, GPSM3, EIF4A2
 686
TBPL1_TARGET_GENES 1.90e-02 5.66 1.11 9.97e-01 1.00e+00
3EEF1A1, PABPC1, NAP1L1
 144
SMAD_Q6 1.80e-02 4.28 1.11 9.97e-01 1.00e+00
4HNRNPA1, ARHGDIB, ARID5A, CREM
 258
SUPT16H_TARGET_GENES 1.91e-02 2.28 1.11 9.97e-01 1.00e+00
13EEF1A1, RPL13, EEF2, HNRNPA1, EEF1D, TMSB4X, COMMD6, RPL18, CIRBP, LEF1, EIF4A2, ALDOA, BTG1
 1944

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_FORMATION_OF_CYTOPLASMIC_TRANSLATION_INITIATION_COMPLEX 3.90e-07 90.00 20.43 5.83e-04 2.92e-03
4EIF3E, EIF3L, EIF3H, EIF3F
 16
GOBP_CYTOPLASMIC_TRANSLATIONAL_INITIATION 2.06e-07 47.76 13.82 5.13e-04 1.54e-03
5EIF3E, EIF3L, EIF3H, EIF3F, EIF4A2
 34
GOBP_CYTOPLASMIC_TRANSLATION 5.49e-09 25.29 9.99 4.11e-05 4.11e-05
8RPSA, EIF3E, EEF2, EIF3L, RPL18, EIF3H, EIF3F, EIF4A2
 102
GOBP_SEQUESTERING_OF_ACTIN_MONOMERS 6.85e-04 64.86 6.55 1.97e-01 1.00e+00
2TMSB4X, TMSB10
 10
GOBP_TRANSLATIONAL_INITIATION 5.10e-08 14.91 6.28 1.91e-04 3.82e-04
9RPL13, RPSA, EIF3E, PABPC1, EIF3L, RPL18, EIF3H, EIF3F, EIF4A2
 193
GOBP_VIRAL_TRANSLATION 1.80e-03 37.11 3.99 4.14e-01 1.00e+00
2EIF3L, EIF3F
 16
GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 1.06e-04 12.07 3.67 5.48e-02 7.91e-01
5RPL13, RPSA, EIF3E, PABPC1, RPL18
 120
GOBP_AEROBIC_RESPIRATION 3.63e-04 13.24 3.39 1.29e-01 1.00e+00
4COX7C, UQCRB, COX4I1, OXA1L
 86
GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS 3.51e-07 6.70 3.32 5.83e-04 2.63e-03
14EEF1A1, RPL13, RPSA, EIF3E, PABPC1, EEF2, EEF1D, EIF3L, RPL18, EIF3H, CIRBP, EIF3F, EIF4A2, OXA1L
 740
GOBP_REGULATION_OF_ACTIN_FILAMENT_LENGTH 8.34e-05 9.47 3.26 4.82e-02 6.24e-01
6TMSB4X, CCR7, TMSB10, ARPC1B, PFN1, CORO1A
 186
GOBP_VIRAL_GENE_EXPRESSION 1.17e-04 8.88 3.05 5.48e-02 8.76e-01
6RPL13, RPSA, EIF3L, RPL18, LEF1, EIF3F
 198
GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN 3.10e-03 27.37 3.01 5.95e-01 1.00e+00
2COX7C, COX4I1
 21
GOBP_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION 5.72e-04 11.68 2.99 1.86e-01 1.00e+00
4CCR7, ARPC1B, PFN1, CORO1A
 97
GOBP_REGULATION_OF_ACTIN_FILAMENT_ORGANIZATION 8.38e-05 7.65 2.88 4.82e-02 6.27e-01
7TMSB4X, CCR7, TMSB10, ARPC1B, PFN1, CORO1A, RGCC
 273
GOBP_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION 1.82e-04 8.16 2.81 8.03e-02 1.00e+00
6TMSB4X, CCR7, TMSB10, ARPC1B, PFN1, CORO1A
 215
GOBP_AMIDE_BIOSYNTHETIC_PROCESS 2.38e-06 5.64 2.80 2.97e-03 1.78e-02
14EEF1A1, RPL13, RPSA, EIF3E, PABPC1, EEF2, EEF1D, EIF3L, RPL18, EIF3H, CIRBP, EIF3F, EIF4A2, OXA1L
 877
GOBP_NEGATIVE_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION 4.10e-04 8.90 2.72 1.39e-01 1.00e+00
5PFDN5, TMSB4X, TMSB10, PFN1, CORO1A
 161
GOBP_PEPTIDE_METABOLIC_PROCESS 3.28e-06 5.47 2.72 3.50e-03 2.45e-02
14EEF1A1, RPL13, RPSA, EIF3E, PABPC1, EEF2, EEF1D, EIF3L, RPL18, EIF3H, CIRBP, EIF3F, EIF4A2, OXA1L
 903
GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION 2.32e-04 7.78 2.68 9.15e-02 1.00e+00
6TMSB4X, CCR7, TMSB10, ARPC1B, PFN1, CORO1A
 225
GOBP_REGULATION_OF_SUPRAMOLECULAR_FIBER_ORGANIZATION 7.87e-05 6.58 2.65 4.82e-02 5.88e-01
8PFDN5, TMSB4X, CCR7, TMSB10, ARPC1B, PFN1, CORO1A, RGCC
 370

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_UP 6.65e-19 35.18 18.04 3.24e-15 3.24e-15
17RPL13, PABPC1, EEF2, TPT1, EEF1D, PFDN5, EIF3L, UQCRB, RPL18, EIF3H, COX4I1, CIRBP, CD7, EIF3F, FBL, UXT, SNRPD2
 200
GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_UP 1.02e-11 21.21 9.93 2.49e-08 4.98e-08
12RPL13, EEF2, TPT1, EEF1D, EIF3L, COMMD6, RPL18, LTB, EIF3F, NAP1L1, FBL, UXT
 198
GSE5099_CLASSICAL_M1_VS_ALTERNATIVE_M2_MACROPHAGE_UP 1.71e-10 19.26 8.76 2.18e-07 8.31e-07
11RPL13, PABPC1, EEF2, COX7C, PFDN5, CCR7, ARID5A, PLAC8, GYPC, EIF3F, BTG1
 194
GSE22886_NAIVE_CD4_TCELL_VS_DC_UP 2.01e-10 18.95 8.62 2.18e-07 9.78e-07
11EIF3E, EEF2, HNRNPA1, CCR7, EIF3H, CD7, GYPC, LEF1, EIF3F, UXT, BTG1
 197
GSE22886_NAIVE_TCELL_VS_DC_UP 2.23e-10 18.75 8.53 2.18e-07 1.09e-06
11HNRNPA1, EEF1D, PFDN5, CCR7, SELL, GYPC, LEF1, EIF3F, GPSM3, UXT, BTG1
 199
GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_2H_UP 3.54e-09 16.80 7.38 1.90e-06 1.72e-05
10RPL13, PABPC1, PFDN5, EIF3L, UQCRB, COMMD6, ARHGDIB, LTB, EIF3F, OST4
 196
GSE10325_CD4_TCELL_VS_LUPUS_CD4_TCELL_UP 3.72e-09 16.71 7.34 1.90e-06 1.81e-05
10EIF3E, PFDN5, EIF3L, RPL18, EIF3H, EIF3F, FBL, UXT, BTG1, RGCC
 197
GSE22886_NAIVE_CD8_TCELL_VS_DC_UP 4.09e-09 16.53 7.26 1.90e-06 1.99e-05
10EIF3E, EEF2, HNRNPA1, EIF3H, LTB, CD7, GYPC, EIF3F, UXT, SNRPD2
 199
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_4H_DN 4.09e-09 16.53 7.26 1.90e-06 1.99e-05
10RPL13, EIF3E, EEF1D, EIF3L, RPL18, EIF3H, CIRBP, EIF3F, BTG1, OXA1L
 199
GSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 4.29e-09 16.45 7.22 1.90e-06 2.09e-05
10RPL13, RPSA, EIF3E, TPT1, FXYD5, UQCRB, RPL18, EIF3H, GYPC, CORO1A
 200
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_2H_DN 4.29e-09 16.45 7.22 1.90e-06 2.09e-05
10RPL13, EIF3E, EEF2, PFDN5, EIF3L, FXYD5, EIF3H, EIF3F, FBL, UXT
 200
GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_DN 2.21e-08 16.53 6.95 8.98e-06 1.08e-04
9RPL13, EEF2, RPL18, CCR7, PLAC8, LTB, CD7, LEF1, FBL
 175
GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_UP 6.08e-08 14.60 6.15 2.02e-05 2.96e-04
9TPT1, EEF1D, UQCRB, CIRBP, PLAC8, LEF1, LYPD3, BTG1, RGCC
 197
GSE22886_NAIVE_TCELL_VS_NKCELL_UP 6.34e-08 14.52 6.11 2.02e-05 3.09e-04
9EIF3E, PABPC1, CCR7, EIF3H, LTB, LEF1, GPSM3, UXT, OXA1L
 198
GSE36476_CTRL_VS_TSST_ACT_16H_MEMORY_CD4_TCELL_YOUNG_UP 6.34e-08 14.52 6.11 2.02e-05 3.09e-04
9COX7C, UQCRB, CD52, ARHGDIB, CIRBP, PLAC8, LEF1, LYPD3, BTG1
 198
GSE6269_FLU_VS_E_COLI_INF_PBMC_DN 2.19e-07 15.26 6.09 6.28e-05 1.07e-03
8RPL13, EEF2, EIF3L, COX4I1, GYPC, EIF3F, NAP1L1, FBL
 164
GSE26156_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_UP 6.62e-08 14.44 6.08 2.02e-05 3.22e-04
9RPL13, TPT1, PFDN5, CCR7, CIRBP, CREM, LTB, EIF4A2, BTG1
 199
GSE3720_UNSTIM_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_UP 3.58e-07 14.26 5.69 9.58e-05 1.74e-03
8EEF1A1, RPSA, RPL18, PLAC8, LTB, SELL, LEF1, FBL
 175
GSE6269_HEALTHY_VS_FLU_INF_PBMC_UP 3.74e-07 14.17 5.66 9.58e-05 1.82e-03
8RPL13, TOMM7, EIF3L, EIF3H, COX4I1, EIF3F, FBL, UXT
 176
GSE3565_DUSP1_VS_WT_SPLENOCYTES_DN 4.24e-07 13.93 5.56 1.03e-04 2.07e-03
8EEF2, RPL18, PLAC8, LTB, CD7, SELL, LEF1, FBL
 179

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
HNRNPA1 10 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1PGZ)
COMMD6 17 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ARID5A 24 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
CREM 27 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
LEF1 33 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RGCC 49 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ATXN7 63 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ATXN7 SCA7 domain facilitates interactions with histone dimers (PMID: 20634802)
ELF1 69 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TCF7 70 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TSC22D3 73 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF.
RNF125 82 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ubiguitin ligase
ZFP36L2 88 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 20506496).
KLF2 100 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PCBP2 102 No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is an RBP. Structure (PDB:2PQU) is with single stranded DNA
STAT4 109 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
NFATC1 128 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PRKCH 130 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase that activates another kinase leading to degradation of NFKB inhibitor NFKBIA (PMID: 21820409)
CIB1 132 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
TXK 151 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Experimental evidence for DNA-binding was performed with nuclear extract - thus, the apparent specific-binding of TXK could be due to indirect binding (PMID: 11859127). In addition a whitepaper suggests that this interaction could not be replicated (Miskimins, Beth)
CSRNP1 157 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None All three paralogs (CSRNP1, CSRNP2, and CSRNP3) bind an AGAGTG consensus based on SELEX experiments (PMID: 17726538)


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T34_GCCTCTATCAGATAAG.1 Neurons:adrenal_medulla_cell_line 0.13 431.98
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.22, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.22, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.21, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:fibroblast-derived:Retroviral_transf: 0.21, iPS_cells:PDB_2lox-17: 0.21, iPS_cells:PDB_2lox-21: 0.21
T44_GACGTTAGTTCTCATT.1 Neurons:adrenal_medulla_cell_line 0.16 341.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, Tissue_stem_cells:CD326-CD56+: 0.23, iPS_cells:PDB_2lox-22: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_2lox-21: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.22
T34_CCACCTACATAAGACA.1 GMP 0.13 337.41
Raw ScoresPro-B_cell_CD34+: 0.38, GMP: 0.38, CMP: 0.37, Pro-Myelocyte: 0.35, MEP: 0.35, HSC_CD34+: 0.35, T_cell:gamma-delta: 0.35, BM: 0.34, Pre-B_cell_CD34-: 0.34, B_cell:Germinal_center: 0.33
T40_CAGGTGCTCGACAGCC.1 Erythroblast 0.12 300.70
Raw ScoresMEP: 0.4, Erythroblast: 0.39, CMP: 0.36, Pro-Myelocyte: 0.35, GMP: 0.35, Pro-B_cell_CD34+: 0.35, BM: 0.34, HSC_CD34+: 0.33, T_cell:gamma-delta: 0.32, NK_cell:IL2: 0.31
T92_CTGCCTACAGCTGTGC.1 Neurons:adrenal_medulla_cell_line 0.18 276.72
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_2lox-17: 0.24, iPS_cells:PDB_2lox-5: 0.24
T44_AGGTCATGTAGGCATG.1 Neurons:adrenal_medulla_cell_line 0.13 274.90
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Tissue_stem_cells:CD326-CD56+: 0.22, Neurons:Schwann_cell: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.21, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.21, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.21, Smooth_muscle_cells:umbilical_vein: 0.21
T69_GGCAATTTCGTTACGA.1 Smooth_muscle_cells:vascular:IL-17 0.17 265.15
Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.34, Smooth_muscle_cells:vascular: 0.33, Fibroblasts:breast: 0.33, Tissue_stem_cells:BM_MSC: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.32, iPS_cells:adipose_stem_cells: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, Chondrocytes:MSC-derived: 0.32, Fibroblasts:foreskin: 0.31, Tissue_stem_cells:BM_MSC:osteogenic: 0.31
T27_TAAACCGTCTATGTGG.1 Neurons:adrenal_medulla_cell_line 0.12 259.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.24, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22, iPS_cells:PDB_2lox-17: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.22, iPS_cells:PDB_2lox-21: 0.22, iPS_cells:PDB_2lox-5: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22
T40_ATTATCCTCCATTCTA.1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.13 253.43
Raw ScoresMacrophage:monocyte-derived: 0.4, DC:monocyte-derived:anti-DC-SIGN_2h: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.39, DC:monocyte-derived:AM580: 0.39, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.39, Monocyte:leukotriene_D4: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, DC:monocyte-derived: 0.39, Macrophage:monocyte-derived:IL-4/TGFb: 0.39, Macrophage:monocyte-derived:M-CSF: 0.39
T27_CAGTAACGTACCGCTG.1 Neurons:adrenal_medulla_cell_line 0.09 244.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neuroepithelial_cell:ESC-derived: 0.22, Neurons:Schwann_cell: 0.2, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.2, Endothelial_cells:HUVEC:FPV-infected: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.2, iPS_cells:PDB_2lox-22: 0.2, iPS_cells:PDB_2lox-17: 0.2
T92_TATTACCAGGCGTACA.1 T_cell:gamma-delta 0.15 242.19
Raw ScoresT_cell:gamma-delta: 0.39, T_cell:CD4+_central_memory: 0.35, NK_cell:IL2: 0.35, T_cell:CD4+_effector_memory: 0.34, T_cell:effector: 0.34, T_cell:CCR10-CLA+1,25(OH)2_vit_D3/IL-12: 0.34, Pre-B_cell_CD34-: 0.33, T_cell:CD8+_Central_memory: 0.33, T_cell:CD8+: 0.33, T_cell:CD8+_effector_memory_RA: 0.33
T44_CCGTACTTCAGCTCGG.1 Neurons:adrenal_medulla_cell_line 0.17 241.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, Tissue_stem_cells:CD326-CD56+: 0.23, Embryonic_stem_cells: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_2lox-5: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23
T44_CGGAGCTTCCAGTAGT.1 Neurons:adrenal_medulla_cell_line 0.14 240.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.24, Embryonic_stem_cells: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:fibroblast-derived:Retroviral_transf: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.22, Tissue_stem_cells:CD326-CD56+: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22
T44_TACGGGCGTCTTGATG.1 Neurons:adrenal_medulla_cell_line 0.16 237.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_2lox-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_2lox-17: 0.22, iPS_cells:PDB_2lox-21: 0.22
T27_CCTACACGTCTCTCGT.1 Neurons:adrenal_medulla_cell_line 0.12 237.09
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.22, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:PDB_2lox-21: 0.21, iPS_cells:PDB_2lox-17: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_2lox-5: 0.21
T34_ATCATGGCAGTCAGCC.1 Neurons:adrenal_medulla_cell_line 0.14 233.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.22, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.2, iPS_cells:PDB_2lox-22: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_2lox-21: 0.2, Embryonic_stem_cells: 0.2
T44_CTCGGGAGTGACTCAT.1 Neurons:adrenal_medulla_cell_line 0.16 230.49
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.21, Tissue_stem_cells:CD326-CD56+: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:PDB_2lox-17: 0.21, iPS_cells:PDB_2lox-21: 0.21, iPS_cells:PDB_2lox-5: 0.21
T34_AACGTTGTCTTTAGGG.1 Neurons:adrenal_medulla_cell_line 0.14 226.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22
T34_GGATGTTGTTAAGACA.1 Neurons:adrenal_medulla_cell_line 0.13 218.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.23, Tissue_stem_cells:CD326-CD56+: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.22, iPS_cells:PDB_2lox-21: 0.22, iPS_cells:PDB_2lox-17: 0.22, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22, iPS_cells:PDB_2lox-5: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22
T40_GTGCAGCTCAAACCGT.1 Monocyte:leukotriene_D4 0.12 218.23
Raw ScoresPre-B_cell_CD34-: 0.4, Monocyte:CD14+: 0.39, Monocyte:CD16+: 0.39, Monocyte:leukotriene_D4: 0.39, Monocyte:CD16-: 0.39, Monocyte:anti-FcgRIIB: 0.39, Monocyte: 0.39, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, HSC_-G-CSF: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg: 0.38
T44_AGTGGGAAGTAGTGCG.1 Neurons:adrenal_medulla_cell_line 0.15 215.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22, Tissue_stem_cells:CD326-CD56+: 0.21, Neurons:Schwann_cell: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:iPS:minicircle-derived: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21
T34_AGCGGTCTCTCGGACG.1 Neurons:adrenal_medulla_cell_line 0.17 212.07
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.24, Tissue_stem_cells:CD326-CD56+: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24
T27_CATTCGCTCTTTACAC.1 Neurons:adrenal_medulla_cell_line 0.10 210.82
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.22, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, iPS_cells:PDB_2lox-17: 0.21, iPS_cells:PDB_2lox-21: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21
T44_GCTGCGATCCGTTGCT.1 Neurons:adrenal_medulla_cell_line 0.15 210.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_2lox-5: 0.22, iPS_cells:PDB_2lox-21: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_2lox-17: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22
T92_GCATGTAAGTATGACA.1 Neurons:adrenal_medulla_cell_line 0.15 209.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_2lox-21: 0.24, iPS_cells:PDB_2lox-5: 0.24, iPS_cells:PDB_2lox-17: 0.24
T27_AACTCAGAGCACAGGT.1 B_cell:CXCR4-_centrocyte 0.16 207.75
Raw ScoresB_cell:Germinal_center: 0.38, B_cell:CXCR4-_centrocyte: 0.38, B_cell:CXCR4+_centroblast: 0.37, B_cell:Memory: 0.37, B_cell:Plasma_cell: 0.36, B_cell:Naive: 0.35, B_cell:immature: 0.35, Pro-B_cell_CD34+: 0.33, Pre-B_cell_CD34-: 0.32, T_cell:gamma-delta: 0.31
T40_GACGCGTCATTGGGCC.1 Pro-B_cell_CD34+ 0.15 201.35
Raw ScoresPro-B_cell_CD34+: 0.39, GMP: 0.38, CMP: 0.37, MEP: 0.35, Pro-Myelocyte: 0.35, HSC_CD34+: 0.35, B_cell:immature: 0.34, BM: 0.34, Pre-B_cell_CD34-: 0.34, B_cell:Germinal_center: 0.33
T69_CTCACACTCCAGAGGA.1 Neurons:adrenal_medulla_cell_line 0.17 197.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.29, iPS_cells:PDB_2lox-22: 0.28
T34_GTAACGTCACCGTTGG.1 Neurons:adrenal_medulla_cell_line 0.14 195.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_2lox-17: 0.24, Tissue_stem_cells:CD326-CD56+: 0.24, iPS_cells:PDB_2lox-21: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24
T34_CGGACTGGTGCTTCTC.1 Neurons:adrenal_medulla_cell_line 0.18 194.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23
T40_CGCGTTTGTAGCAAAT.1 Macrophage:monocyte-derived:IL-4/cntrl 0.19 190.94
Raw ScoresMacrophage:monocyte-derived:IL-4/cntrl: 0.44, Macrophage:monocyte-derived:IL-4/TGFb: 0.43, DC:monocyte-derived:Galectin-1: 0.43, Macrophage:monocyte-derived: 0.43, Macrophage:monocyte-derived:IFNa: 0.43, DC:monocyte-derived:AM580: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, Macrophage:monocyte-derived:S._aureus: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, Macrophage:Alveolar:B._anthacis_spores: 0.43
T69_CGGGTCACACCAACCG.1 Tissue_stem_cells:BM_MSC 0.12 189.24
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.29, Smooth_muscle_cells:vascular:IL-17: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, Smooth_muscle_cells:vascular: 0.28, Tissue_stem_cells:BM_MSC: 0.28, Chondrocytes:MSC-derived: 0.28, iPS_cells:adipose_stem_cells: 0.28, Fibroblasts:breast: 0.28, Tissue_stem_cells:BM_MSC:osteogenic: 0.27, Osteoblasts: 0.27
T92_TCGGGACTCACTCCTG.1 Neurons:adrenal_medulla_cell_line 0.12 181.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.24, iPS_cells:PDB_2lox-21: 0.23, iPS_cells:PDB_2lox-22: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_2lox-17: 0.23, Tissue_stem_cells:CD326-CD56+: 0.23
T27_GAACGGAGTATTACCG.1 Neurons:adrenal_medulla_cell_line 0.08 180.48
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, T_cell:CD4+_Naive: 0.21, T_cell:CD4+_central_memory: 0.21, T_cell:CD4+_effector_memory: 0.2, T_cell:CD8+_effector_memory: 0.2, B_cell:Memory: 0.19, T_cell:CD4+: 0.19, B_cell:Germinal_center: 0.19, Pro-B_cell_CD34+: 0.19, B_cell:Naive: 0.19
T40_TGGGAAGCAATAAGCA.1 Monocyte:CD16- 0.14 175.51
Raw ScoresMonocyte:CD16-: 0.37, Monocyte:CD16+: 0.37, Monocyte:CD14+: 0.36, Monocyte:leukotriene_D4: 0.36, Monocyte: 0.36, Monocyte:anti-FcgRIIB: 0.36, Pre-B_cell_CD34-: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.35
T27_CACAGTAAGGTACTCT.1 T_cell:CD4+_central_memory 0.07 175.32
Raw ScoresT_cell:CD4+_central_memory: 0.26, T_cell:CD4+_Naive: 0.26, T_cell:CD4+_effector_memory: 0.25, T_cell:CD8+_effector_memory: 0.25, NK_cell:CD56hiCD62L+: 0.24, T_cell:CD4+: 0.24, T_cell:CD8+_naive: 0.24, T_cell:CD8+: 0.24, NK_cell: 0.24, T_cell:CD8+_Central_memory: 0.23
T92_GCAGTTACATGGATGG.1 Neurons:adrenal_medulla_cell_line 0.14 173.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_2lox-21: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-22: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25, iPS_cells:PDB_2lox-17: 0.25
T44_GATGAGGTCGTTGACA.1 Neurons:adrenal_medulla_cell_line 0.14 173.34
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.26, Tissue_stem_cells:CD326-CD56+: 0.24, Embryonic_stem_cells: 0.23, iPS_cells:fibroblast-derived:Retroviral_transf: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:PDB_2lox-17: 0.23, iPS_cells:PDB_2lox-5: 0.23
T40_TAGGCATGTGGTACAG.1 DC:monocyte-derived:antiCD40/VAF347 0.17 171.43
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.4, DC:monocyte-derived:Galectin-1: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.4, DC:monocyte-derived:LPS: 0.4, DC:monocyte-derived: 0.4, DC:monocyte-derived:anti-DC-SIGN_2h: 0.39, Macrophage:monocyte-derived:IFNa: 0.39, Macrophage:Alveolar:B._anthacis_spores: 0.39
T40_GTAACTGAGTTGAGAT.1 T_cell:CD4+_central_memory 0.13 164.03
Raw ScoresT_cell:CD4+_central_memory: 0.35, T_cell:CD4+_effector_memory: 0.35, T_cell:CD4+_Naive: 0.35, T_cell:CD8+: 0.34, T_cell:CD4+: 0.33, T_cell:CD8+_effector_memory: 0.33, NK_cell: 0.33, T_cell:gamma-delta: 0.32, T_cell:CD8+_naive: 0.32, T_cell:CD8+_Central_memory: 0.32
T69_ACGCCGACAAGGGTCA.1 Neurons:adrenal_medulla_cell_line 0.11 163.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_2lox-22: 0.19, iPS_cells:PDB_2lox-17: 0.19, iPS_cells:PDB_2lox-21: 0.19, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19
T27_GCGACCAAGCGTGAGT.1 B_cell:Germinal_center 0.17 162.85
Raw ScoresB_cell:Germinal_center: 0.39, B_cell:CXCR4+_centroblast: 0.38, B_cell:CXCR4-_centrocyte: 0.37, B_cell:Memory: 0.36, B_cell:immature: 0.36, B_cell:Naive: 0.35, Pro-B_cell_CD34+: 0.35, B_cell:Plasma_cell: 0.34, T_cell:gamma-delta: 0.33, Pre-B_cell_CD34-: 0.32
T27_ATTATCCGTGAGGCTA.1 Neurons:adrenal_medulla_cell_line 0.13 160.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.25, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22
T44_TAGTGGTGTCTCTCGT.1 Neurons:adrenal_medulla_cell_line 0.15 160.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Tissue_stem_cells:CD326-CD56+: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_2lox-21: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_2lox-5: 0.22
T34_CCTATTAGTATAGGTA.1 Neurons:adrenal_medulla_cell_line 0.16 158.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.22, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.21, iPS_cells:PDB_2lox-22: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21
T27_CTCGAAAAGAGGTTAT.1 Neurons:adrenal_medulla_cell_line 0.10 157.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.25, T_cell:CD4+_Naive: 0.25, T_cell:CD4+_central_memory: 0.25, NK_cell:CD56hiCD62L+: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, T_cell:CD4+_effector_memory: 0.25, Pro-B_cell_CD34+: 0.24, T_cell:CD8+_effector_memory: 0.24
T27_GCGCCAAAGACTAGGC.1 Neurons:adrenal_medulla_cell_line 0.18 155.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_2lox-22: 0.21
T92_GGCGTGTCAGGTCGTC.1 DC:monocyte-derived:Poly(IC) 0.15 153.40
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.37, Macrophage:monocyte-derived:IFNa: 0.37, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.37, Macrophage:monocyte-derived: 0.37, DC:monocyte-derived:Poly(IC): 0.36, DC:monocyte-derived:immature: 0.36, Macrophage:Alveolar:B._anthacis_spores: 0.36, DC:monocyte-derived:CD40L: 0.36, DC:monocyte-derived:antiCD40/VAF347: 0.36, Macrophage:Alveolar: 0.36
T44_ACGGAGAAGACTGGGT.1 Neurons:adrenal_medulla_cell_line 0.18 153.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:fibroblast-derived:Retroviral_transf: 0.24, iPS_cells:PDB_2lox-21: 0.24, Embryonic_stem_cells: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.24
T92_CGCTATCAGTTAAGTG.1 Neurons:adrenal_medulla_cell_line 0.16 150.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.25, Tissue_stem_cells:CD326-CD56+: 0.25, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_2lox-22: 0.25, Endothelial_cells:HUVEC:FPV-infected: 0.25


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Other T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.98e-05
Mean rank of genes in gene set: 520.5
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CCR7 0.0039314 19 GTEx DepMap Descartes 1.13 176.38
SELL 0.0029603 31 GTEx DepMap Descartes 0.73 103.10
LEF1 0.0028812 33 GTEx DepMap Descartes 0.53 52.78
TCF7 0.0019795 70 GTEx DepMap Descartes 0.54 34.24
CD4 0.0000353 839 GTEx DepMap Descartes 0.18 13.74
FOXP3 -0.0001723 2131 GTEx DepMap Descartes 0.01 1.86


Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.39e-03
Mean rank of genes in gene set: 17.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
EIF3E 0.0072348 4 GTEx DepMap Descartes 4.20 523.24
EIF3L 0.0043609 14 GTEx DepMap Descartes 4.24 263.92
EIF3F 0.0028574 34 GTEx DepMap Descartes 2.97 96.13


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.64e-03
Mean rank of genes in gene set: 4931.1
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CNN2 0.0023756 51 GTEx DepMap Descartes 0.47 66.89
TGFBR2 0.0001868 576 GTEx DepMap Descartes 0.17 9.61
MYH11 0.0000846 725 GTEx DepMap Descartes 0.00 0.19
COL13A1 -0.0001067 1600 GTEx DepMap Descartes 0.00 0.13
COL10A1 -0.0001113 1630 GTEx DepMap Descartes 0.00 0.00
THBS1 -0.0001806 2191 GTEx DepMap Descartes 0.03 0.73
IGFBP3 -0.0001841 2229 GTEx DepMap Descartes 0.02 0.91
POSTN -0.0001957 2327 GTEx DepMap Descartes 0.00 0.13
ACTA2 -0.0001965 2334 GTEx DepMap Descartes 0.06 7.39
TGFB2 -0.0002591 2882 GTEx DepMap Descartes 0.01 0.25
ACTG2 -0.0002626 2909 GTEx DepMap Descartes 0.00 0.03
MYL9 -0.0002753 3000 GTEx DepMap Descartes 0.05 2.61
MEF2C -0.0002901 3131 GTEx DepMap Descartes 0.13 4.57
COL11A1 -0.0003123 3342 GTEx DepMap Descartes 0.00 0.06
MYLK -0.0003380 3556 GTEx DepMap Descartes 0.01 0.18
TAGLN -0.0003392 3568 GTEx DepMap Descartes 0.05 2.40
COL8A1 -0.0003393 3569 GTEx DepMap Descartes 0.02 0.33
VEGFA -0.0003822 3902 GTEx DepMap Descartes 0.12 1.41
LUM -0.0003953 4014 GTEx DepMap Descartes 0.06 5.23
COL5A1 -0.0004070 4103 GTEx DepMap Descartes 0.01 0.19
BGN -0.0004090 4119 GTEx DepMap Descartes 0.02 1.39
COL1A1 -0.0004117 4143 GTEx DepMap Descartes 0.21 5.67
TGFB1 -0.0004190 4207 GTEx DepMap Descartes 0.47 55.87
COL15A1 -0.0004291 4289 GTEx DepMap Descartes 0.01 0.34
COL3A1 -0.0004384 4360 GTEx DepMap Descartes 0.11 3.13
COL14A1 -0.0004729 4626 GTEx DepMap Descartes 0.00 0.14
TNC -0.0004808 4698 GTEx DepMap Descartes 0.01 0.11
WNT5A -0.0004844 4724 GTEx DepMap Descartes 0.01 0.23
COL5A2 -0.0004885 4755 GTEx DepMap Descartes 0.01 0.35
DCN -0.0004972 4830 GTEx DepMap Descartes 0.09 2.22
THBS2 -0.0004979 4842 GTEx DepMap Descartes 0.01 0.28
MMP11 -0.0005000 4851 GTEx DepMap Descartes 0.01 0.56
COL1A2 -0.0005003 4853 GTEx DepMap Descartes 0.13 3.32
COL12A1 -0.0005087 4921 GTEx DepMap Descartes 0.01 0.17
FN1 -0.0005424 5193 GTEx DepMap Descartes 0.07 1.23
ITGA7 -0.0005935 5579 GTEx DepMap Descartes 0.01 0.49
PGF -0.0006090 5700 GTEx DepMap Descartes 0.11 4.58
IGFBP7 -0.0006097 5707 GTEx DepMap Descartes 0.62 64.30
COL4A1 -0.0006580 6084 GTEx DepMap Descartes 0.05 1.07
TMEM119 -0.0006769 6230 GTEx DepMap Descartes 0.03 1.62
HOPX -0.0007049 6425 GTEx DepMap Descartes 0.18 18.34
TPM2 -0.0009951 8460 GTEx DepMap Descartes 0.10 9.61
MMP2 -0.0011138 9103 GTEx DepMap Descartes 0.05 2.36
TGFBR1 -0.0011872 9453 GTEx DepMap Descartes 0.15 4.28
THY1 -0.0014552 10495 GTEx DepMap Descartes 0.15 4.84
TPM1 -0.0018863 11511 GTEx DepMap Descartes 0.47 17.31
VCAN -0.0019501 11612 GTEx DepMap Descartes 0.24 3.31
CNN3 -0.0020937 11792 GTEx DepMap Descartes 0.26 20.62
RGS5 -0.0034078 12423 GTEx DepMap Descartes 3.71 92.48




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9670.68
Median rank of genes in gene set: 10414
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LEPROTL1 0.0015092 113 GTEx DepMap Descartes 1.76 189.58
CXCR4 0.0008604 217 GTEx DepMap Descartes 4.00 734.71
CCNI 0.0007888 232 GTEx DepMap Descartes 7.48 562.40
UCP2 0.0006867 263 GTEx DepMap Descartes 1.07 155.62
HK2 0.0002425 503 GTEx DepMap Descartes 0.05 1.32
EVL 0.0002008 552 GTEx DepMap Descartes 1.97 149.24
SATB1 0.0001931 563 GTEx DepMap Descartes 0.55 19.72
ABLIM1 0.0001768 599 GTEx DepMap Descartes 0.19 7.60
EML4 0.0001112 679 GTEx DepMap Descartes 0.48 27.54
PDK1 -0.0000206 1049 GTEx DepMap Descartes 0.08 1.41
BMPR1B -0.0000219 1052 GTEx DepMap Descartes 0.20 5.48
FAM167A -0.0001580 2011 GTEx DepMap Descartes 0.02 1.00
HMGA1 -0.0001640 2062 GTEx DepMap Descartes 1.61 142.12
GLDC -0.0003444 3607 GTEx DepMap Descartes 0.00 0.10
RIMS3 -0.0003534 3671 GTEx DepMap Descartes 0.20 3.72
ESRRG -0.0003970 4022 GTEx DepMap Descartes 0.02 0.45
BEND4 -0.0004285 4286 GTEx DepMap Descartes 0.00 0.10
STRA6 -0.0004289 4287 GTEx DepMap Descartes 0.00 0.33
DIABLO -0.0004616 4545 GTEx DepMap Descartes 0.09 4.92
GRB10 -0.0004925 4788 GTEx DepMap Descartes 0.03 1.10
RET -0.0005043 4889 GTEx DepMap Descartes 0.02 0.47
HEY1 -0.0005202 5018 GTEx DepMap Descartes 0.03 1.26
PARP6 -0.0005204 5023 GTEx DepMap Descartes 0.31 14.01
SERP2 -0.0005293 5096 GTEx DepMap Descartes 0.39 61.46
MYRIP -0.0005352 5138 GTEx DepMap Descartes 0.01 0.30
POPDC3 -0.0005443 5206 GTEx DepMap Descartes 0.01 0.54
DAPK1 -0.0005565 5312 GTEx DepMap Descartes 0.08 1.79
CELF2 -0.0005744 5448 GTEx DepMap Descartes 0.44 14.57
TBC1D30 -0.0005892 5541 GTEx DepMap Descartes 0.04 0.70
LMO3 -0.0005951 5589 GTEx DepMap Descartes 0.02 0.70


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.95e-02
Mean rank of genes in gene set: 6008.93
Median rank of genes in gene set: 5419
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ARPC1B 0.0026768 42 GTEx DepMap Descartes 1.94 303.30
RGS10 0.0020440 67 GTEx DepMap Descartes 1.79 586.15
ELF1 0.0019987 69 GTEx DepMap Descartes 0.77 79.30
TSC22D3 0.0019129 73 GTEx DepMap Descartes 3.01 467.03
PTGER4 0.0015377 108 GTEx DepMap Descartes 0.58 60.68
LITAF 0.0014184 119 GTEx DepMap Descartes 1.10 125.63
IFITM2 0.0014102 120 GTEx DepMap Descartes 1.59 597.02
B2M 0.0013107 136 GTEx DepMap Descartes 43.73 5926.96
ABRACL 0.0011431 158 GTEx DepMap Descartes 0.89 NA
RAP1A 0.0009478 196 GTEx DepMap Descartes 0.56 34.26
INSIG1 0.0007735 236 GTEx DepMap Descartes 0.35 31.07
SUCLG2 0.0006982 257 GTEx DepMap Descartes 0.15 20.15
CD44 0.0004099 379 GTEx DepMap Descartes 1.88 84.15
SNAP23 0.0003744 404 GTEx DepMap Descartes 0.14 16.04
PCSK5 0.0003035 453 GTEx DepMap Descartes 0.03 0.77
ETS1 0.0002824 471 GTEx DepMap Descartes 0.44 30.08
CBFB 0.0002050 548 GTEx DepMap Descartes 0.33 22.89
TGFBR2 0.0001868 576 GTEx DepMap Descartes 0.17 9.61
POLR2L 0.0001828 584 GTEx DepMap Descartes 1.72 484.37
LRP10 0.0001689 611 GTEx DepMap Descartes 0.17 8.00
REST 0.0001204 666 GTEx DepMap Descartes 0.14 6.01
NPC2 0.0001034 693 GTEx DepMap Descartes 1.18 151.33
SLC30A7 0.0000893 719 GTEx DepMap Descartes 0.12 3.55
TCF7L2 0.0000775 738 GTEx DepMap Descartes 0.06 2.06
CMTM3 0.0000559 779 GTEx DepMap Descartes 0.30 33.28
NOTCH2 0.0000358 835 GTEx DepMap Descartes 0.05 1.27
PLEKHA2 0.0000171 892 GTEx DepMap Descartes 0.11 5.72
MYLIP 0.0000125 906 GTEx DepMap Descartes 0.15 14.71
PDE7B 0.0000095 916 GTEx DepMap Descartes 0.02 0.87
DLX2 -0.0000006 953 GTEx DepMap Descartes 0.00 0.09


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 7477.47
Median rank of genes in gene set: 7425.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SGCZ -0.0000038 968 GTEx DepMap Descartes 0.01 0.23
STAR -0.0000719 1359 GTEx DepMap Descartes 0.01 0.51
FREM2 -0.0000812 1409 GTEx DepMap Descartes 0.00 0.00
LDLR -0.0001013 1563 GTEx DepMap Descartes 0.09 4.64
DHCR24 -0.0002778 3032 GTEx DepMap Descartes 0.09 2.54
BAIAP2L1 -0.0003608 3725 GTEx DepMap Descartes 0.00 0.24
INHA -0.0004959 4819 GTEx DepMap Descartes 0.00 0.71
DHCR7 -0.0005006 4856 GTEx DepMap Descartes 0.09 8.57
PAPSS2 -0.0005065 4900 GTEx DepMap Descartes 0.02 0.72
NPC1 -0.0005460 5220 GTEx DepMap Descartes 0.03 1.66
SCARB1 -0.0005831 5502 GTEx DepMap Descartes 0.06 1.76
APOC1 -0.0006645 6137 GTEx DepMap Descartes 2.98 567.18
FDXR -0.0007165 6506 GTEx DepMap Descartes 0.07 5.57
FDX1 -0.0007302 6609 GTEx DepMap Descartes 0.38 31.71
FRMD5 -0.0007669 6865 GTEx DepMap Descartes 0.02 0.65
SLC16A9 -0.0007819 6991 GTEx DepMap Descartes 0.04 1.47
PDE10A -0.0008033 7142 GTEx DepMap Descartes 0.02 0.47
SH3PXD2B -0.0008382 7393 GTEx DepMap Descartes 0.02 0.40
GRAMD1B -0.0008471 7458 GTEx DepMap Descartes 0.02 0.75
ERN1 -0.0009027 7849 GTEx DepMap Descartes 0.13 4.98
CYB5B -0.0009722 8317 GTEx DepMap Descartes 0.30 16.50
HMGCS1 -0.0010460 8741 GTEx DepMap Descartes 0.19 6.47
MSMO1 -0.0011390 9218 GTEx DepMap Descartes 0.14 12.82
IGF1R -0.0011745 9395 GTEx DepMap Descartes 0.13 1.68
SCAP -0.0011786 9415 GTEx DepMap Descartes 0.11 4.83
PEG3 -0.0011843 9438 GTEx DepMap Descartes 0.17 NA
TM7SF2 -0.0014565 10499 GTEx DepMap Descartes 0.21 18.10
POR -0.0014637 10523 GTEx DepMap Descartes 0.14 11.34
SLC1A2 -0.0015005 10641 GTEx DepMap Descartes 0.08 0.97
HMGCR -0.0016651 11093 GTEx DepMap Descartes 0.12 4.68


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8742.32
Median rank of genes in gene set: 9185
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLXNA4 0.0002727 475 GTEx DepMap Descartes 0.13 1.34
RBFOX1 0.0001745 602 GTEx DepMap Descartes 0.23 7.30
ANKFN1 0.0000964 708 GTEx DepMap Descartes 0.02 0.68
EPHA6 -0.0001823 2212 GTEx DepMap Descartes 0.00 0.16
PTCHD1 -0.0003239 3442 GTEx DepMap Descartes 0.05 0.54
SLC44A5 -0.0003254 3454 GTEx DepMap Descartes 0.01 0.46
HS3ST5 -0.0004359 4342 GTEx DepMap Descartes 0.06 1.91
EYA4 -0.0005551 5299 GTEx DepMap Descartes 0.04 1.01
RYR2 -0.0007408 6674 GTEx DepMap Descartes 0.02 0.18
TMEFF2 -0.0008309 7351 GTEx DepMap Descartes 0.23 9.65
RPH3A -0.0008764 7686 GTEx DepMap Descartes 0.02 0.49
SYNPO2 -0.0009158 7945 GTEx DepMap Descartes 0.08 0.81
ALK -0.0009316 8064 GTEx DepMap Descartes 0.02 0.46
STMN2 -0.0009554 8217 GTEx DepMap Descartes 14.11 1067.20
REEP1 -0.0009690 8300 GTEx DepMap Descartes 0.19 7.38
EYA1 -0.0010178 8578 GTEx DepMap Descartes 0.04 1.32
CNKSR2 -0.0010243 8615 GTEx DepMap Descartes 0.07 1.49
GREM1 -0.0010422 8715 GTEx DepMap Descartes 0.01 0.18
FAT3 -0.0010530 8790 GTEx DepMap Descartes 0.04 0.31
GAL -0.0010747 8908 GTEx DepMap Descartes 0.62 111.07
ELAVL2 -0.0011313 9185 GTEx DepMap Descartes 0.43 16.02
KCNB2 -0.0012045 9526 GTEx DepMap Descartes 0.04 1.46
RGMB -0.0012095 9552 GTEx DepMap Descartes 0.28 8.55
SLC6A2 -0.0012428 9704 GTEx DepMap Descartes 0.11 4.24
CNTFR -0.0012581 9788 GTEx DepMap Descartes 0.53 35.58
MAB21L2 -0.0014208 10375 GTEx DepMap Descartes 0.29 16.46
TMEM132C -0.0016117 10965 GTEx DepMap Descartes 0.09 2.52
IL7 -0.0016387 11024 GTEx DepMap Descartes 0.34 24.33
GAP43 -0.0019626 11628 GTEx DepMap Descartes 2.28 165.80
MLLT11 -0.0022568 11970 GTEx DepMap Descartes 4.30 264.64


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.70e-04
Mean rank of genes in gene set: 4172.89
Median rank of genes in gene set: 3280
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CEACAM1 0.0004794 346 GTEx DepMap Descartes 0.03 2.61
CDH13 0.0002859 469 GTEx DepMap Descartes 0.03 0.56
BTNL9 0.0000110 909 GTEx DepMap Descartes 0.00 0.12
F8 -0.0000056 977 GTEx DepMap Descartes 0.01 0.28
CRHBP -0.0000124 1007 GTEx DepMap Descartes 0.01 0.53
ESM1 -0.0001258 1741 GTEx DepMap Descartes 0.00 0.06
SHE -0.0001339 1803 GTEx DepMap Descartes 0.00 0.03
KANK3 -0.0001565 1997 GTEx DepMap Descartes 0.01 1.01
RASIP1 -0.0001707 2116 GTEx DepMap Descartes 0.01 0.45
NPR1 -0.0001903 2278 GTEx DepMap Descartes 0.00 0.02
SLCO2A1 -0.0001961 2329 GTEx DepMap Descartes 0.00 0.00
NR5A2 -0.0002532 2822 GTEx DepMap Descartes 0.00 0.02
FLT4 -0.0002591 2883 GTEx DepMap Descartes 0.00 0.04
KDR -0.0002661 2938 GTEx DepMap Descartes 0.00 0.06
PLVAP -0.0002751 2996 GTEx DepMap Descartes 0.01 1.03
MMRN2 -0.0002826 3074 GTEx DepMap Descartes 0.00 0.18
TIE1 -0.0002941 3165 GTEx DepMap Descartes 0.00 0.10
EHD3 -0.0003015 3236 GTEx DepMap Descartes 0.02 0.42
CDH5 -0.0003038 3260 GTEx DepMap Descartes 0.00 0.05
PTPRB -0.0003087 3300 GTEx DepMap Descartes 0.00 0.03
GALNT15 -0.0003106 3323 GTEx DepMap Descartes 0.00 NA
CALCRL -0.0003171 3383 GTEx DepMap Descartes 0.01 0.24
ROBO4 -0.0003303 3491 GTEx DepMap Descartes 0.00 0.10
TMEM88 -0.0003828 3906 GTEx DepMap Descartes 0.05 12.20
SHANK3 -0.0004443 4412 GTEx DepMap Descartes 0.01 0.18
ID1 -0.0004827 4711 GTEx DepMap Descartes 0.11 26.19
PODXL -0.0005017 4866 GTEx DepMap Descartes 0.02 0.47
MYRIP -0.0005352 5138 GTEx DepMap Descartes 0.01 0.30
CLDN5 -0.0005497 5250 GTEx DepMap Descartes 0.03 1.54
TEK -0.0005797 5477 GTEx DepMap Descartes 0.00 0.03


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.93e-05
Mean rank of genes in gene set: 4031.23
Median rank of genes in gene set: 3679.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FREM1 -0.0000200 1048 GTEx DepMap Descartes 0.00 0.07
LAMC3 -0.0000278 1076 GTEx DepMap Descartes 0.00 0.00
COL27A1 -0.0000442 1176 GTEx DepMap Descartes 0.00 0.08
DKK2 -0.0001008 1561 GTEx DepMap Descartes 0.00 0.06
RSPO3 -0.0001375 1843 GTEx DepMap Descartes 0.00 NA
IGFBP3 -0.0001841 2229 GTEx DepMap Descartes 0.02 0.91
MGP -0.0001881 2264 GTEx DepMap Descartes 0.12 9.18
ITGA11 -0.0001938 2309 GTEx DepMap Descartes 0.00 0.06
POSTN -0.0001957 2327 GTEx DepMap Descartes 0.00 0.13
ACTA2 -0.0001965 2334 GTEx DepMap Descartes 0.06 7.39
SFRP2 -0.0002076 2435 GTEx DepMap Descartes 0.00 0.00
CD248 -0.0002203 2541 GTEx DepMap Descartes 0.04 4.77
SCARA5 -0.0002459 2774 GTEx DepMap Descartes 0.00 0.00
ABCC9 -0.0002742 2990 GTEx DepMap Descartes 0.00 0.01
EDNRA -0.0002870 3111 GTEx DepMap Descartes 0.00 0.09
ADAMTSL3 -0.0003223 3430 GTEx DepMap Descartes 0.00 0.01
ABCA6 -0.0003272 3467 GTEx DepMap Descartes 0.01 0.17
C7 -0.0003304 3493 GTEx DepMap Descartes 0.01 0.15
GAS2 -0.0003376 3551 GTEx DepMap Descartes 0.00 0.32
GLI2 -0.0003379 3555 GTEx DepMap Descartes 0.00 0.01
OGN -0.0003391 3567 GTEx DepMap Descartes 0.01 0.50
CCDC80 -0.0003408 3585 GTEx DepMap Descartes 0.05 0.50
PRRX1 -0.0003669 3774 GTEx DepMap Descartes 0.00 0.12
PAMR1 -0.0003890 3956 GTEx DepMap Descartes 0.00 0.19
ELN -0.0003892 3959 GTEx DepMap Descartes 0.04 1.17
LUM -0.0003953 4014 GTEx DepMap Descartes 0.06 5.23
BICC1 -0.0004022 4066 GTEx DepMap Descartes 0.01 0.19
LRRC17 -0.0004082 4115 GTEx DepMap Descartes 0.00 0.34
COL1A1 -0.0004117 4143 GTEx DepMap Descartes 0.21 5.67
LOX -0.0004125 4151 GTEx DepMap Descartes 0.01 0.18


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.68e-01
Mean rank of genes in gene set: 6375.66
Median rank of genes in gene set: 6079
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TENM1 0.0000077 922 GTEx DepMap Descartes 0.03 NA
GRM7 -0.0000153 1023 GTEx DepMap Descartes 0.00 0.13
CNTN3 -0.0000976 1534 GTEx DepMap Descartes 0.00 0.13
CDH12 -0.0001400 1862 GTEx DepMap Descartes 0.01 0.39
SLC35F3 -0.0001430 1890 GTEx DepMap Descartes 0.01 0.50
PENK -0.0001815 2200 GTEx DepMap Descartes 0.00 0.05
KSR2 -0.0002657 2935 GTEx DepMap Descartes 0.05 0.41
ST18 -0.0002790 3045 GTEx DepMap Descartes 0.00 0.04
SORCS3 -0.0003240 3443 GTEx DepMap Descartes 0.00 0.10
LAMA3 -0.0003452 3620 GTEx DepMap Descartes 0.00 0.04
FGF14 -0.0004123 4150 GTEx DepMap Descartes 0.06 0.76
CDH18 -0.0004295 4293 GTEx DepMap Descartes 0.01 0.27
SLC18A1 -0.0005168 4989 GTEx DepMap Descartes 0.10 4.37
ROBO1 -0.0005460 5218 GTEx DepMap Descartes 0.08 1.79
MGAT4C -0.0005799 5480 GTEx DepMap Descartes 0.06 0.35
PCSK2 -0.0006156 5764 GTEx DepMap Descartes 0.01 0.56
TBX20 -0.0006366 5919 GTEx DepMap Descartes 0.00 0.24
NTNG1 -0.0006400 5943 GTEx DepMap Descartes 0.02 0.65
DGKK -0.0006453 5993 GTEx DepMap Descartes 0.01 0.27
GRID2 -0.0006672 6165 GTEx DepMap Descartes 0.02 0.55
CCSER1 -0.0006857 6291 GTEx DepMap Descartes 0.01 NA
AGBL4 -0.0007286 6590 GTEx DepMap Descartes 0.02 0.87
GCH1 -0.0007320 6619 GTEx DepMap Descartes 0.23 15.09
SLC24A2 -0.0007399 6669 GTEx DepMap Descartes 0.01 0.08
TIAM1 -0.0007602 6824 GTEx DepMap Descartes 0.10 3.06
EML6 -0.0007868 7025 GTEx DepMap Descartes 0.02 0.24
KCTD16 -0.0008047 7150 GTEx DepMap Descartes 0.26 3.05
SPOCK3 -0.0008797 7705 GTEx DepMap Descartes 0.03 1.60
PACRG -0.0009866 8412 GTEx DepMap Descartes 0.06 4.86
GALNTL6 -0.0010412 8707 GTEx DepMap Descartes 0.01 0.53


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.42e-01
Mean rank of genes in gene set: 5555.66
Median rank of genes in gene set: 5397
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GYPC 0.0029343 32 GTEx DepMap Descartes 1.38 264.53
SLC25A21 -0.0000476 1196 GTEx DepMap Descartes 0.00 0.00
RGS6 -0.0000585 1271 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000733 1367 GTEx DepMap Descartes 0.01 0.47
RHD -0.0001026 1572 GTEx DepMap Descartes 0.00 0.06
ALAS2 -0.0002626 2908 GTEx DepMap Descartes 0.01 0.77
SELENBP1 -0.0002990 3212 GTEx DepMap Descartes 0.00 0.23
CPOX -0.0003223 3431 GTEx DepMap Descartes 0.03 3.04
SPTB -0.0003599 3718 GTEx DepMap Descartes 0.02 0.31
MARCH3 -0.0003783 3876 GTEx DepMap Descartes 0.04 NA
MICAL2 -0.0004131 4159 GTEx DepMap Descartes 0.02 1.07
SOX6 -0.0004518 4470 GTEx DepMap Descartes 0.06 0.78
ABCB10 -0.0004784 4671 GTEx DepMap Descartes 0.05 2.23
TMCC2 -0.0005128 4952 GTEx DepMap Descartes 0.03 0.94
TFR2 -0.0005676 5397 GTEx DepMap Descartes 0.03 1.55
TRAK2 -0.0006188 5786 GTEx DepMap Descartes 0.06 2.12
ANK1 -0.0006399 5942 GTEx DepMap Descartes 0.03 0.62
DENND4A -0.0006552 6059 GTEx DepMap Descartes 0.15 4.67
GCLC -0.0007260 6572 GTEx DepMap Descartes 0.05 2.76
SPECC1 -0.0007291 6595 GTEx DepMap Descartes 0.05 1.25
BLVRB -0.0007512 6756 GTEx DepMap Descartes 0.23 29.65
SNCA -0.0009722 8318 GTEx DepMap Descartes 0.33 16.80
XPO7 -0.0009964 8469 GTEx DepMap Descartes 0.08 2.84
FECH -0.0010734 8900 GTEx DepMap Descartes 0.07 1.83
CAT -0.0010753 8910 GTEx DepMap Descartes 0.18 20.91
RAPGEF2 -0.0011941 9483 GTEx DepMap Descartes 0.08 1.62
SLC25A37 -0.0013753 10240 GTEx DepMap Descartes 0.19 8.73
EPB41 -0.0015507 10786 GTEx DepMap Descartes 0.25 10.79
TSPAN5 -0.0023799 12066 GTEx DepMap Descartes 0.26 11.97
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.50e-01
Mean rank of genes in gene set: 5879.24
Median rank of genes in gene set: 5687.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD74 0.0004065 384 GTEx DepMap Descartes 8.98 655.70
FGD2 -0.0000504 1210 GTEx DepMap Descartes 0.02 0.88
AXL -0.0001748 2150 GTEx DepMap Descartes 0.06 2.08
HCK -0.0001816 2203 GTEx DepMap Descartes 0.07 5.27
FMN1 -0.0002083 2437 GTEx DepMap Descartes 0.04 0.45
HRH1 -0.0002382 2686 GTEx DepMap Descartes 0.01 0.38
PTPRE -0.0003409 3588 GTEx DepMap Descartes 0.15 6.71
SFMBT2 -0.0003643 3752 GTEx DepMap Descartes 0.04 1.47
MERTK -0.0004023 4068 GTEx DepMap Descartes 0.01 0.36
ATP8B4 -0.0004139 4167 GTEx DepMap Descartes 0.01 0.29
SLC9A9 -0.0004329 4319 GTEx DepMap Descartes 0.04 3.34
SLCO2B1 -0.0004407 4383 GTEx DepMap Descartes 0.03 0.82
RGL1 -0.0004583 4519 GTEx DepMap Descartes 0.02 0.56
SLC1A3 -0.0004867 4738 GTEx DepMap Descartes 0.02 0.58
MARCH1 -0.0005521 5274 GTEx DepMap Descartes 0.06 NA
MS4A4A -0.0005635 5361 GTEx DepMap Descartes 0.07 6.54
WWP1 -0.0005708 5424 GTEx DepMap Descartes 0.08 4.31
CD163 -0.0005897 5544 GTEx DepMap Descartes 0.02 0.62
CD163L1 -0.0005918 5564 GTEx DepMap Descartes 0.22 6.67
SPP1 -0.0006232 5811 GTEx DepMap Descartes 2.17 167.98
CSF1R -0.0006743 6208 GTEx DepMap Descartes 0.06 2.50
MSR1 -0.0006816 6261 GTEx DepMap Descartes 0.03 1.27
ABCA1 -0.0006858 6295 GTEx DepMap Descartes 0.05 0.74
TGFBI -0.0007112 6462 GTEx DepMap Descartes 0.12 4.51
CST3 -0.0007715 6912 GTEx DepMap Descartes 2.62 137.85
LGMN -0.0008346 7373 GTEx DepMap Descartes 0.21 16.56
CTSB -0.0008381 7392 GTEx DepMap Descartes 0.94 43.16
ADAP2 -0.0008683 7616 GTEx DepMap Descartes 0.05 2.79
CTSD -0.0009036 7857 GTEx DepMap Descartes 1.35 120.59
FGL2 -0.0009132 7925 GTEx DepMap Descartes 0.13 5.36


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.76e-01
Mean rank of genes in gene set: 5768.43
Median rank of genes in gene set: 5232.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TRPM3 0.0002724 476 GTEx DepMap Descartes 0.00 0.04
PAG1 0.0000146 896 GTEx DepMap Descartes 0.36 8.65
IL1RAPL2 -0.0000509 1214 GTEx DepMap Descartes 0.00 0.00
MDGA2 -0.0001188 1685 GTEx DepMap Descartes 0.00 0.06
IL1RAPL1 -0.0001215 1704 GTEx DepMap Descartes 0.00 0.04
XKR4 -0.0001333 1800 GTEx DepMap Descartes 0.02 0.14
HMGA2 -0.0001375 1842 GTEx DepMap Descartes 0.00 0.02
PTPRZ1 -0.0001612 2038 GTEx DepMap Descartes 0.00 0.04
NRXN3 -0.0001648 2070 GTEx DepMap Descartes 0.01 0.20
ERBB3 -0.0002289 2617 GTEx DepMap Descartes 0.01 0.36
ADAMTS5 -0.0002454 2765 GTEx DepMap Descartes 0.00 0.01
LRRTM4 -0.0002557 2849 GTEx DepMap Descartes 0.02 0.86
MPZ -0.0002930 3154 GTEx DepMap Descartes 0.02 2.71
OLFML2A -0.0003034 3259 GTEx DepMap Descartes 0.00 0.08
EDNRB -0.0003346 3527 GTEx DepMap Descartes 0.00 0.10
PLP1 -0.0004163 4188 GTEx DepMap Descartes 0.00 0.38
COL18A1 -0.0004610 4538 GTEx DepMap Descartes 0.08 3.63
COL5A2 -0.0004885 4755 GTEx DepMap Descartes 0.01 0.35
COL25A1 -0.0004895 4765 GTEx DepMap Descartes 0.00 0.05
ERBB4 -0.0005315 5109 GTEx DepMap Descartes 0.00 0.01
STARD13 -0.0005397 5170 GTEx DepMap Descartes 0.01 0.28
SLC35F1 -0.0005468 5224 GTEx DepMap Descartes 0.02 0.57
VIM -0.0005486 5241 GTEx DepMap Descartes 4.44 459.77
PLCE1 -0.0005879 5535 GTEx DepMap Descartes 0.02 0.43
LAMA4 -0.0006061 5677 GTEx DepMap Descartes 0.08 1.64
EGFLAM -0.0006067 5682 GTEx DepMap Descartes 0.02 0.54
LAMC1 -0.0006547 6056 GTEx DepMap Descartes 0.02 0.44
KCTD12 -0.0006644 6136 GTEx DepMap Descartes 0.07 1.82
GAS7 -0.0006835 6277 GTEx DepMap Descartes 0.02 0.56
GRIK3 -0.0007005 6400 GTEx DepMap Descartes 0.01 0.10


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.68e-02
Mean rank of genes in gene set: 5129.71
Median rank of genes in gene set: 3732
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMSB4X 0.0044288 13 GTEx DepMap Descartes 86.88 14274.19
SLC2A3 0.0011884 152 GTEx DepMap Descartes 0.77 57.55
SPN 0.0006758 264 GTEx DepMap Descartes 0.17 7.51
FLI1 0.0006395 276 GTEx DepMap Descartes 0.09 5.61
PSTPIP2 0.0000887 720 GTEx DepMap Descartes 0.02 1.40
INPP4B -0.0000032 964 GTEx DepMap Descartes 0.12 4.38
RAB27B -0.0000387 1138 GTEx DepMap Descartes 0.04 1.08
GP1BA -0.0000413 1156 GTEx DepMap Descartes 0.00 0.11
MMRN1 -0.0000658 1318 GTEx DepMap Descartes 0.00 0.08
ITGB3 -0.0001031 1575 GTEx DepMap Descartes 0.00 0.00
THBS1 -0.0001806 2191 GTEx DepMap Descartes 0.03 0.73
SLC24A3 -0.0001934 2305 GTEx DepMap Descartes 0.00 0.22
MCTP1 -0.0002088 2442 GTEx DepMap Descartes 0.02 0.60
TUBB1 -0.0002429 2736 GTEx DepMap Descartes 0.00 0.16
TRPC6 -0.0002490 2790 GTEx DepMap Descartes 0.00 0.01
ZYX -0.0002573 2867 GTEx DepMap Descartes 0.33 33.95
ARHGAP6 -0.0002801 3055 GTEx DepMap Descartes 0.00 0.00
ANGPT1 -0.0002884 3119 GTEx DepMap Descartes 0.00 0.05
FERMT3 -0.0002992 3216 GTEx DepMap Descartes 0.25 29.74
UBASH3B -0.0003100 3316 GTEx DepMap Descartes 0.03 1.31
MYLK -0.0003380 3556 GTEx DepMap Descartes 0.01 0.18
ITGA2B -0.0003528 3666 GTEx DepMap Descartes 0.01 0.30
LTBP1 -0.0003618 3732 GTEx DepMap Descartes 0.00 0.05
TGFB1 -0.0004190 4207 GTEx DepMap Descartes 0.47 55.87
MYH9 -0.0004435 4404 GTEx DepMap Descartes 0.40 16.29
CD84 -0.0005399 5172 GTEx DepMap Descartes 0.08 1.99
P2RX1 -0.0005488 5242 GTEx DepMap Descartes 0.01 1.12
DOK6 -0.0005851 5517 GTEx DepMap Descartes 0.04 0.71
MED12L -0.0006111 5722 GTEx DepMap Descartes 0.01 0.15
VCL -0.0007507 6751 GTEx DepMap Descartes 0.07 1.49


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.82e-11
Mean rank of genes in gene set: 2581.5
Median rank of genes in gene set: 825.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ARHGDIB 0.0034273 22 GTEx DepMap Descartes 3.84 1050.64
LEF1 0.0028812 33 GTEx DepMap Descartes 0.53 52.78
TMSB10 0.0026977 41 GTEx DepMap Descartes 49.95 24434.33
CCND3 0.0022273 55 GTEx DepMap Descartes 0.71 100.23
PRKCH 0.0013667 130 GTEx DepMap Descartes 0.25 24.98
B2M 0.0013107 136 GTEx DepMap Descartes 43.73 5926.96
ITPKB 0.0009776 194 GTEx DepMap Descartes 0.11 6.17
PDE3B 0.0008869 212 GTEx DepMap Descartes 0.35 19.87
ARHGAP15 0.0007913 231 GTEx DepMap Descartes 0.35 40.45
ANKRD44 0.0006946 260 GTEx DepMap Descartes 0.25 11.49
WIPF1 0.0005527 316 GTEx DepMap Descartes 0.49 36.80
SAMD3 0.0004566 359 GTEx DepMap Descartes 0.14 13.34
CD44 0.0004099 379 GTEx DepMap Descartes 1.88 84.15
FOXP1 0.0003790 402 GTEx DepMap Descartes 0.96 27.32
PITPNC1 0.0003040 450 GTEx DepMap Descartes 0.25 12.55
IKZF1 0.0002927 461 GTEx DepMap Descartes 0.36 19.95
ETS1 0.0002824 471 GTEx DepMap Descartes 0.44 30.08
SKAP1 0.0002664 479 GTEx DepMap Descartes 0.31 66.43
EVL 0.0002008 552 GTEx DepMap Descartes 1.97 149.24
ABLIM1 0.0001768 599 GTEx DepMap Descartes 0.19 7.60
SCML4 0.0000553 780 GTEx DepMap Descartes 0.14 9.01
NCALD 0.0000232 871 GTEx DepMap Descartes 0.08 4.60
PLEKHA2 0.0000171 892 GTEx DepMap Descartes 0.11 5.72
GNG2 -0.0000418 1159 GTEx DepMap Descartes 0.69 43.91
SORL1 -0.0001619 2046 GTEx DepMap Descartes 0.23 6.03
MBNL1 -0.0002622 2907 GTEx DepMap Descartes 0.41 20.45
BACH2 -0.0002857 3098 GTEx DepMap Descartes 0.14 4.31
SP100 -0.0003001 3228 GTEx DepMap Descartes 0.29 17.83
RCSD1 -0.0003493 3642 GTEx DepMap Descartes 0.20 12.12
ARID5B -0.0003510 3654 GTEx DepMap Descartes 0.30 13.57


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


T cells: Tcm/Naive cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.56e-03
Mean rank of genes in gene set: 94.33
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CCR7 0.0039314 19 GTEx DepMap Descartes 1.13 176.38
SELL 0.0029603 31 GTEx DepMap Descartes 0.73 103.10
CD8A 0.0007839 233 GTEx DepMap Descartes 0.51 61.07


T cells: Tcm/Naive helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.13e-03
Mean rank of genes in gene set: 296.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CCR7 0.0039314 19 GTEx DepMap Descartes 1.13 176.38
SELL 0.0029603 31 GTEx DepMap Descartes 0.73 103.10
CD4 0.0000353 839 GTEx DepMap Descartes 0.18 13.74


T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.43e-03
Mean rank of genes in gene set: 2420.14
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
BIRC3 0.0015449 107 GTEx DepMap Descartes 0.67 33.84
B2M 0.0013107 136 GTEx DepMap Descartes 43.73 5926.96
COTL1 0.0011352 159 GTEx DepMap Descartes 2.07 107.58
ITM2A 0.0009175 204 GTEx DepMap Descartes 0.85 170.33
CD74 0.0004065 384 GTEx DepMap Descartes 8.98 655.70
PTPRC -0.0003867 3932 GTEx DepMap Descartes 1.16 76.14
SMS -0.0023155 12019 GTEx DepMap Descartes 1.04 105.93