Program: 4. Macrophage.

Program: 4. Macrophage.

Program description and justification of annotation: 4.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 SPP1 0.0298595 secreted phosphoprotein 1 GTEx DepMap Descartes 11.14 16904.96
2 MMP12 0.0173984 matrix metallopeptidase 12 GTEx DepMap Descartes 0.43 694.16
3 APOE 0.0162972 apolipoprotein E GTEx DepMap Descartes 2.06 4173.35
4 APOC1 0.0140010 apolipoprotein C1 GTEx DepMap Descartes 1.35 4965.71
5 CTSD 0.0133510 cathepsin D GTEx DepMap Descartes 1.66 2008.08
6 ACP5 0.0112574 acid phosphatase 5, tartrate resistant GTEx DepMap Descartes 0.34 531.48
7 MITF 0.0108242 melanocyte inducing transcription factor GTEx DepMap Descartes 0.57 282.58
8 CTSB 0.0097785 cathepsin B GTEx DepMap Descartes 1.21 829.79
9 CTSZ 0.0096236 cathepsin Z GTEx DepMap Descartes 0.64 937.30
10 NEAT1 0.0092469 nuclear paraspeckle assembly transcript 1 GTEx DepMap Descartes 6.58 596.42
11 SLC2A3 0.0092391 solute carrier family 2 member 3 GTEx DepMap Descartes 0.64 323.63
12 SLC11A1 0.0092208 solute carrier family 11 member 1 GTEx DepMap Descartes 0.32 150.29
13 HMOX1 0.0091138 heme oxygenase 1 GTEx DepMap Descartes 0.30 466.62
14 ITGAX 0.0090952 integrin subunit alpha X GTEx DepMap Descartes 0.37 192.72
15 IL1RN 0.0089180 interleukin 1 receptor antagonist GTEx DepMap Descartes 0.18 226.90
16 GPNMB 0.0083548 glycoprotein nmb GTEx DepMap Descartes 0.45 394.84
17 CAPG 0.0078786 capping actin protein, gelsolin like GTEx DepMap Descartes 0.18 316.73
18 SLC16A10 0.0078610 solute carrier family 16 member 10 GTEx DepMap Descartes 0.70 198.47
19 LAPTM5 0.0077848 lysosomal protein transmembrane 5 GTEx DepMap Descartes 0.36 379.38
20 PLAUR 0.0077670 plasminogen activator, urokinase receptor GTEx DepMap Descartes 0.39 658.70
21 CD109 0.0076756 CD109 molecule GTEx DepMap Descartes 0.18 43.88
22 TYROBP 0.0076193 transmembrane immune signaling adaptor TYROBP GTEx DepMap Descartes 0.28 1005.51
23 TM4SF19 0.0075697 transmembrane 4 L six family member 19 GTEx DepMap Descartes 0.01 11.25
24 MMP19 0.0073309 matrix metallopeptidase 19 GTEx DepMap Descartes 0.24 173.22
25 TRPM3 0.0070133 transient receptor potential cation channel subfamily M member 3 GTEx DepMap Descartes 0.95 166.63
26 CHST11 0.0068036 carbohydrate sulfotransferase 11 GTEx DepMap Descartes 1.03 431.72
27 PSAP 0.0066719 prosaposin GTEx DepMap Descartes 1.51 1173.42
28 CD14 0.0064117 CD14 molecule GTEx DepMap Descartes 0.23 346.68
29 RGS1 0.0062721 regulator of G protein signaling 1 GTEx DepMap Descartes 0.28 263.52
30 TFRC 0.0062348 transferrin receptor GTEx DepMap Descartes 0.74 396.03
31 ARHGAP26 0.0061790 Rho GTPase activating protein 26 GTEx DepMap Descartes 2.36 512.95
32 TGFBI 0.0061742 transforming growth factor beta induced GTEx DepMap Descartes 0.32 164.77
33 ZEB2 0.0061579 zinc finger E-box binding homeobox 2 GTEx DepMap Descartes 1.67 413.08
34 CSTB 0.0061527 cystatin B GTEx DepMap Descartes 0.50 NA
35 ITGB2 0.0061108 integrin subunit beta 2 GTEx DepMap Descartes 0.23 102.67
36 SLC16A3 0.0060900 solute carrier family 16 member 3 GTEx DepMap Descartes 0.26 121.21
37 RAB31 0.0060777 RAB31, member RAS oncogene family GTEx DepMap Descartes 0.36 219.44
38 CD68 0.0059503 CD68 molecule GTEx DepMap Descartes 0.08 96.09
39 S100A10 0.0059398 S100 calcium binding protein A10 GTEx DepMap Descartes 0.18 593.98
40 SRGN 0.0059010 serglycin GTEx DepMap Descartes 0.49 949.73
41 PAM 0.0058616 peptidylglycine alpha-amidating monooxygenase GTEx DepMap Descartes 2.04 768.86
42 S100A4 0.0058178 S100 calcium binding protein A4 GTEx DepMap Descartes 0.22 700.92
43 FCER1G 0.0057312 Fc epsilon receptor Ig GTEx DepMap Descartes 0.17 649.08
44 RAB20 0.0055960 RAB20, member RAS oncogene family GTEx DepMap Descartes 0.16 260.03
45 GNAS 0.0055629 GNAS complex locus GTEx DepMap Descartes 4.19 2001.95
46 HIF1A 0.0052630 hypoxia inducible factor 1 subunit alpha GTEx DepMap Descartes 1.00 580.88
47 RREB1 0.0051386 ras responsive element binding protein 1 GTEx DepMap Descartes 0.29 64.81
48 ELL2 0.0051379 elongation factor for RNA polymerase II 2 GTEx DepMap Descartes 0.65 228.79
49 B2M 0.0051099 beta-2-microglobulin GTEx DepMap Descartes 2.15 1602.43
50 HK2 0.0051072 hexokinase 2 GTEx DepMap Descartes 0.16 70.90


Dowload full table

UMAP plots showing activity of gene expression program identified in community:4. Macrophage

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MACROPHAGES 1.14e-14 50.30 22.29 4.78e-13 7.65e-12
11APOE, APOC1, LAPTM5, PLAUR, TYROBP, CD14, RGS1, ITGB2, CD68, SRGN, FCER1G
 81
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_DENDRITIC_CELLS 4.80e-16 42.17 19.96 2.93e-14 3.22e-13
13NEAT1, SLC11A1, LAPTM5, PLAUR, TYROBP, PSAP, CD14, ZEB2, ITGB2, CD68, SRGN, S100A4, FCER1G
 117
TRAVAGLINI_LUNG_MACROPHAGE_CELL 1.94e-20 38.41 19.91 4.35e-18 1.30e-17
18APOE, APOC1, CTSD, ACP5, CTSB, SLC11A1, IL1RN, GPNMB, CAPG, PLAUR, TYROBP, MMP19, PSAP, TGFBI, CSTB, RAB31, S100A10, FCER1G
 201
TRAVAGLINI_LUNG_TREM2_DENDRITIC_CELL 1.52e-25 29.28 16.04 1.02e-22 1.02e-22
28SPP1, APOE, APOC1, CTSD, ACP5, CTSB, CTSZ, NEAT1, SLC11A1, HMOX1, ITGAX, GPNMB, CAPG, PLAUR, TYROBP, PSAP, CD14, TFRC, TGFBI, CSTB, ITGB2, SLC16A3, RAB31, CD68, S100A10, FCER1G, RAB20, GNAS
 572
AIZARANI_LIVER_C25_KUPFFER_CELLS_4 2.89e-15 30.36 14.83 1.38e-13 1.94e-12
14SLC11A1, ITGAX, IL1RN, LAPTM5, PLAUR, TYROBP, PSAP, RGS1, TGFBI, ZEB2, ITGB2, RAB31, SRGN, FCER1G
 174
AIZARANI_LIVER_C23_KUPFFER_CELLS_3 1.10e-16 28.69 14.54 9.22e-15 7.37e-14
16CTSB, SLC2A3, SLC11A1, ITGAX, LAPTM5, PLAUR, TYROBP, PSAP, CD14, ZEB2, ITGB2, RAB31, S100A10, SRGN, S100A4, FCER1G
 221
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 1.79e-16 27.75 14.07 1.20e-14 1.20e-13
16CTSD, CTSB, SLC11A1, HMOX1, ITGAX, GPNMB, LAPTM5, TYROBP, PSAP, CD14, RGS1, TGFBI, ZEB2, ITGB2, RAB31, FCER1G
 228
TRAVAGLINI_LUNG_EREG_DENDRITIC_CELL 1.49e-22 24.52 13.43 4.99e-20 9.97e-20
26CTSB, CTSZ, NEAT1, SLC2A3, SLC11A1, HMOX1, ITGAX, IL1RN, SLC16A10, PLAUR, TYROBP, MMP19, CHST11, PSAP, CD14, TFRC, TGFBI, ZEB2, SLC16A3, RAB31, S100A10, SRGN, FCER1G, RAB20, HIF1A, ELL2
 579
CUI_DEVELOPING_HEART_C8_MACROPHAGE 1.37e-16 24.98 12.86 1.02e-14 9.17e-14
17CTSD, CTSB, NEAT1, SLC2A3, ITGAX, LAPTM5, PLAUR, TYROBP, PSAP, CD14, RGS1, ITGB2, RAB31, CD68, SRGN, S100A4, FCER1G
 275
AIZARANI_LIVER_C18_NK_NKT_CELLS_5 3.22e-11 28.12 12.23 1.03e-09 2.16e-08
10SLC11A1, ITGAX, LAPTM5, PLAUR, TYROBP, PSAP, TGFBI, ZEB2, RAB31, FCER1G
 121
FAN_OVARY_CL13_MONOCYTE_MACROPHAGE 2.31e-19 22.54 12.18 3.10e-17 1.55e-16
22CTSD, CTSB, CTSZ, NEAT1, HMOX1, CAPG, LAPTM5, PLAUR, TYROBP, PSAP, CD14, RGS1, ZEB2, CSTB, ITGB2, SLC16A3, CD68, S100A10, SRGN, S100A4, FCER1G, B2M
 458
TRAVAGLINI_LUNG_OLR1_CLASSICAL_MONOCYTE_CELL 3.47e-20 19.36 10.63 5.81e-18 2.33e-17
26CTSB, NEAT1, SLC2A3, SLC11A1, HMOX1, ITGAX, IL1RN, SLC16A10, PLAUR, TYROBP, MMP19, CHST11, PSAP, CD14, TFRC, TGFBI, ZEB2, CSTB, SLC16A3, RAB31, S100A10, SRGN, FCER1G, RAB20, HIF1A, ELL2
 726
FAN_EMBRYONIC_CTX_BIG_GROUPS_MICROGLIA 9.14e-16 19.93 10.42 5.11e-14 6.13e-13
18SPP1, APOE, APOC1, CTSD, CTSB, NEAT1, HMOX1, ITGAX, LAPTM5, TYROBP, PSAP, CD14, RGS1, ITGB2, CD68, SRGN, FCER1G, B2M
 371
AIZARANI_LIVER_C31_KUPFFER_CELLS_5 8.20e-10 24.70 10.30 2.04e-08 5.50e-07
9CTSB, SLC11A1, ITGAX, IL1RN, PLAUR, TYROBP, PSAP, ZEB2, FCER1G
 120
HU_FETAL_RETINA_MICROGLIA 1.50e-15 19.33 10.11 7.75e-14 1.01e-12
18SPP1, CTSD, CTSB, NEAT1, SLC2A3, HMOX1, ITGAX, LAPTM5, PLAUR, TYROBP, PSAP, CD14, RGS1, ITGB2, RAB31, SRGN, FCER1G, B2M
 382
DESCARTES_FETAL_THYMUS_ANTIGEN_PRESENTING_CELLS 4.74e-11 21.89 9.93 1.45e-09 3.18e-08
11ITGAX, IL1RN, PLAUR, TYROBP, CD14, RGS1, SLC16A3, RAB31, CD68, SRGN, FCER1G
 172
MENON_FETAL_KIDNEY_10_IMMUNE_CELLS 3.25e-08 26.73 9.84 7.04e-07 2.18e-05
7NEAT1, LAPTM5, TYROBP, PSAP, SRGN, S100A4, B2M
 83
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 1.15e-11 20.99 9.83 4.06e-10 7.72e-09
12CTSB, ITGAX, LAPTM5, PLAUR, TYROBP, PSAP, RGS1, TGFBI, ITGB2, RAB31, SRGN, FCER1G
 200
MANNO_MIDBRAIN_NEUROTYPES_HMGL 2.65e-17 17.71 9.59 2.54e-15 1.78e-14
22SPP1, APOE, APOC1, CTSD, CTSB, NEAT1, HMOX1, GPNMB, CAPG, LAPTM5, PLAUR, TYROBP, CD14, RGS1, ARHGAP26, ITGB2, CD68, SRGN, FCER1G, RREB1, ELL2, B2M
 577
DESCARTES_FETAL_CEREBELLUM_MICROGLIA 1.37e-17 17.23 9.37 1.53e-15 9.16e-15
23SPP1, APOE, APOC1, MITF, CTSB, CTSZ, SLC11A1, HMOX1, ITGAX, IL1RN, GPNMB, CAPG, LAPTM5, TYROBP, CD14, RGS1, ITGB2, CD68, S100A4, FCER1G, RAB20, ELL2, HK2
 642

Dowload full table

mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_HYPOXIA 1.19e-05 10.54 3.95 5.94e-04 5.94e-04
7SLC2A3, HMOX1, PLAUR, TGFBI, PAM, S100A4, HK2
 200
HALLMARK_COMPLEMENT 1.24e-04 8.78 3.02 2.06e-03 6.18e-03
6MMP12, APOC1, CTSD, CTSB, PLAUR, FCER1G
 200
HALLMARK_KRAS_SIGNALING_UP 1.24e-04 8.78 3.02 2.06e-03 6.18e-03
6SPP1, GPNMB, LAPTM5, PLAUR, ITGB2, FCER1G
 200
HALLMARK_IL2_STAT5_SIGNALING 1.06e-03 7.16 2.19 1.08e-02 5.28e-02
5SPP1, CTSZ, SLC2A3, CAPG, HK2
 199
HALLMARK_ALLOGRAFT_REJECTION 1.08e-03 7.12 2.18 1.08e-02 5.40e-02
5CAPG, ITGB2, SRGN, HIF1A, B2M
 200
HALLMARK_ANGIOGENESIS 8.94e-03 15.30 1.73 3.73e-02 4.47e-01
2SPP1, S100A4
 36
HALLMARK_MTORC1_SIGNALING 7.71e-03 5.55 1.44 3.50e-02 3.85e-01
4SLC2A3, TFRC, ITGB2, HK2
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 7.71e-03 5.55 1.44 3.50e-02 3.85e-01
4SPP1, CAPG, PLAUR, TGFBI
 200
HALLMARK_INFLAMMATORY_RESPONSE 7.71e-03 5.55 1.44 3.50e-02 3.85e-01
4PLAUR, CD14, RGS1, HIF1A
 200
HALLMARK_GLYCOLYSIS 7.71e-03 5.55 1.44 3.50e-02 3.85e-01
4TGFBI, SLC16A3, PAM, HK2
 200
HALLMARK_P53_PATHWAY 7.71e-03 5.55 1.44 3.50e-02 3.85e-01
4CTSD, HMOX1, S100A10, S100A4
 200
HALLMARK_HEME_METABOLISM 7.71e-03 5.55 1.44 3.50e-02 3.85e-01
4ACP5, CTSB, TFRC, ELL2
 200
HALLMARK_IL6_JAK_STAT3_SIGNALING 4.64e-02 6.13 0.71 1.78e-01 1.00e+00
2HMOX1, CD14
 87
HALLMARK_PROTEIN_SECRETION 5.52e-02 5.54 0.64 1.97e-01 1.00e+00
2PAM, GNAS
 96
HALLMARK_ANDROGEN_RESPONSE 5.93e-02 5.31 0.62 1.98e-01 1.00e+00
2ELL2, B2M
 100
HALLMARK_COAGULATION 1.03e-01 3.83 0.45 3.21e-01 1.00e+00
2APOC1, CTSB
 138
HALLMARK_UV_RESPONSE_UP 1.28e-01 3.34 0.39 3.67e-01 1.00e+00
2HMOX1, TFRC
 158
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 3.67e-01 1.00e+00
2HMOX1, CD14
 161
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.85e-01 2.63 0.31 4.02e-01 1.00e+00
2SLC2A3, PLAUR
 200
HALLMARK_ADIPOGENESIS 1.85e-01 2.63 0.31 4.02e-01 1.00e+00
2APOE, RREB1
 200

Dowload full table

KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_LYSOSOME 2.10e-08 21.07 8.35 3.91e-06 3.91e-06
8CTSD, ACP5, CTSB, CTSZ, SLC11A1, LAPTM5, PSAP, CD68
 121
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.67e-02 5.95 1.17 1.00e+00 1.00e+00
3TYROBP, ITGB2, FCER1G
 137
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.07e-02 3.80 0.75 1.00e+00 1.00e+00
3ITGAX, CD14, ITGB2
 213
KEGG_HEMATOPOIETIC_CELL_LINEAGE 4.64e-02 6.13 0.71 1.00e+00 1.00e+00
2CD14, TFRC
 87
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 4.73e-02 6.05 0.70 1.00e+00 1.00e+00
2CTSB, B2M
 88
KEGG_MELANOGENESIS 6.04e-02 5.26 0.61 1.00e+00 1.00e+00
2MITF, GNAS
 101
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 6.14e-02 5.21 0.60 1.00e+00 1.00e+00
2SPP1, CD14
 102
KEGG_SULFUR_METABOLISM 5.05e-02 21.22 0.49 1.00e+00 1.00e+00
1CHST11
 13
KEGG_RIBOFLAVIN_METABOLISM 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1ACP5
 16
KEGG_ENDOCYTOSIS 1.59e-01 2.91 0.34 1.00e+00 1.00e+00
2TFRC, RAB31
 181
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE 8.40e-02 12.14 0.29 1.00e+00 1.00e+00
1CHST11
 22
KEGG_GALACTOSE_METABOLISM 9.85e-02 10.19 0.24 1.00e+00 1.00e+00
1HK2
 26
KEGG_ASTHMA 1.13e-01 8.79 0.21 1.00e+00 1.00e+00
1FCER1G
 30
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2MITF, HIF1A
 325
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 1.27e-01 7.73 0.19 1.00e+00 1.00e+00
1HK2
 34
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 1.51e-01 6.37 0.15 1.00e+00 1.00e+00
1HMOX1
 41
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1HK2
 44
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1GNAS
 44
KEGG_TYPE_II_DIABETES_MELLITUS 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1HK2
 47
KEGG_TASTE_TRANSDUCTION 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1GNAS
 52

Dowload full table

CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr5q31 1.01e-01 2.81 0.56 1.00e+00 1.00e+00
3CD14, ARHGAP26, TGFBI
 287
chr3q29 8.36e-02 4.34 0.51 1.00e+00 1.00e+00
2TM4SF19, TFRC
 122
chr10q22 1.88e-01 2.60 0.30 1.00e+00 1.00e+00
2PSAP, SRGN
 202
chr19q13 1.00e+00 0.94 0.24 1.00e+00 1.00e+00
4APOE, APOC1, PLAUR, TYROBP
 1165
chr21q22 3.99e-01 1.48 0.17 1.00e+00 1.00e+00
2CSTB, ITGB2
 353
chr3p13 1.47e-01 6.54 0.16 1.00e+00 1.00e+00
1MITF
 40
chr1q21 6.64e-01 1.34 0.16 1.00e+00 1.00e+00
2S100A10, S100A4
 392
chr20q13 6.68e-01 1.31 0.15 1.00e+00 1.00e+00
2CTSZ, GNAS
 400
chr2p12 1.90e-01 4.91 0.12 1.00e+00 1.00e+00
1HK2
 53
chr6q13 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1CD109
 56
chr6p24 2.03e-01 4.55 0.11 1.00e+00 1.00e+00
1RREB1
 57
chr5q15 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1ELL2
 60
chr5q21 2.25e-01 4.05 0.10 1.00e+00 1.00e+00
1PAM
 64
chr2q22 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1ZEB2
 68
chr4q22 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1SPP1
 70
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1RGS1
 71
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1GPNMB
 96
chr11q22 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1MMP12
 98
chr6q21 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1SLC16A10
 117
chr14q23 3.89e-01 2.07 0.05 1.00e+00 1.00e+00
1HIF1A
 124

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
TCANNTGAY_SREBP1_01 7.44e-05 5.84 2.48 8.43e-02 8.43e-02
9CTSD, HMOX1, GPNMB, CD109, TM4SF19, PSAP, RGS1, HIF1A, HK2
 479
HES2_TARGET_GENES 1.14e-03 3.12 1.52 5.01e-01 1.00e+00
13CTSD, MITF, CTSB, NEAT1, HMOX1, CD109, MMP19, TFRC, ARHGAP26, TGFBI, RAB31, S100A10, SRGN
 1420
TFEB_TARGET_GENES 3.04e-03 2.87 1.36 7.60e-01 1.00e+00
12CTSD, ACP5, CTSB, NEAT1, SLC2A3, HMOX1, ITGAX, TGFBI, RAB31, CD68, PAM, HIF1A
 1387
SMN1_SMN2_TARGET_GENES 6.24e-03 3.01 1.28 9.24e-01 1.00e+00
9CTSB, CAPG, TFRC, ARHGAP26, ITGB2, RAB31, S100A4, GNAS, B2M
 922
IRF2_01 1.42e-02 6.33 1.24 9.24e-01 1.00e+00
3MITF, TRPM3, B2M
 129
TGANTCA_AP1_C 7.29e-03 2.77 1.23 9.24e-01 1.00e+00
10MMP12, MITF, SLC11A1, ITGAX, IL1RN, GPNMB, TM4SF19, MMP19, CD68, S100A10
 1139
USF_Q6_01 1.50e-02 4.53 1.17 9.24e-01 1.00e+00
4HMOX1, RAB31, GNAS, HIF1A
 244
GCM_Q2 1.52e-02 4.51 1.17 9.24e-01 1.00e+00
4MITF, CHST11, GNAS, ELL2
 245
SNRNP70_TARGET_GENES 1.06e-02 2.75 1.17 9.24e-01 1.00e+00
9APOE, NEAT1, TFRC, ARHGAP26, ZEB2, SLC16A3, RAB31, CD68, B2M
 1009
CEBPDELTA_Q6 1.56e-02 4.47 1.16 9.24e-01 1.00e+00
4MITF, IL1RN, TRPM3, ZEB2
 247
IRF1_01 1.73e-02 4.33 1.12 9.24e-01 1.00e+00
4MITF, TRPM3, CHST11, B2M
 255
CEBPA_01 1.75e-02 4.31 1.12 9.24e-01 1.00e+00
4MITF, CD109, FCER1G, B2M
 256
TGGAAA_NFAT_Q4_01 1.89e-02 2.29 1.11 9.24e-01 1.00e+00
13SPP1, MITF, IL1RN, TRPM3, CHST11, RGS1, ZEB2, CD68, S100A10, FCER1G, GNAS, HIF1A, RREB1
 1934
USF_01 1.93e-02 4.18 1.09 9.24e-01 1.00e+00
4HMOX1, TFRC, RAB31, GNAS
 264
AP1_Q2 1.96e-02 4.16 1.08 9.24e-01 1.00e+00
4IL1RN, LAPTM5, MMP19, S100A10
 265
AP1_Q6_01 2.00e-02 4.13 1.07 9.24e-01 1.00e+00
4SLC11A1, IL1RN, LAPTM5, MMP19
 267
AP1FJ_Q2 2.10e-02 4.07 1.06 9.24e-01 1.00e+00
4IL1RN, LAPTM5, MMP19, S100A10
 271
AP1_Q4 2.10e-02 4.07 1.06 9.24e-01 1.00e+00
4IL1RN, LAPTM5, MMP19, S100A10
 271
GR_Q6 2.20e-02 4.01 1.04 9.24e-01 1.00e+00
4MITF, CD109, ZEB2, SRGN
 275
GREB1_TARGET_GENES 2.14e-02 2.55 1.03 9.24e-01 1.00e+00
8CTSB, GPNMB, TGFBI, ITGB2, SLC16A3, S100A10, PAM, S100A4
 941

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_POSITIVE_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS 3.22e-04 103.49 9.64 7.53e-02 1.00e+00
2APOE, LAPTM5
 7
GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS 9.37e-06 36.12 8.90 7.01e-03 7.01e-02
4APOE, ITGB2, CD68, FCER1G
 34
GOBP_WOUND_HEALING_INVOLVED_IN_INFLAMMATORY_RESPONSE 4.28e-04 86.37 8.33 8.72e-02 1.00e+00
2HMOX1, HIF1A
 8
GOBP_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE 4.28e-04 86.37 8.33 8.72e-02 1.00e+00
2APOE, APOC1
 8
GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_ESTERIFICATION 5.49e-04 74.10 7.33 9.13e-02 1.00e+00
2APOE, APOC1
 9
GOBP_ELASTIN_METABOLIC_PROCESS 5.49e-04 74.10 7.33 9.13e-02 1.00e+00
2MMP12, HIF1A
 9
GOBP_CELLULAR_RESPONSE_TO_IRON_ION 5.49e-04 74.10 7.33 9.13e-02 1.00e+00
2HMOX1, B2M
 9
GOBP_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE 6.85e-04 64.86 6.55 1.05e-01 1.00e+00
2APOE, APOC1
 10
GOBP_COLLAGEN_CATABOLIC_PROCESS 3.46e-05 25.26 6.32 1.62e-02 2.58e-01
4MMP12, CTSD, CTSB, MMP19
 47
GOBP_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY 8.33e-12 12.09 6.27 3.12e-08 6.23e-08
17CTSD, CTSB, CTSZ, SLC2A3, SLC11A1, HMOX1, ITGAX, PLAUR, TYROBP, PSAP, CD14, CSTB, ITGB2, RAB31, CD68, FCER1G, B2M
 550
GOBP_RESPONSE_TO_IRON_ION 1.81e-04 31.85 5.95 5.27e-02 1.00e+00
3HMOX1, HIF1A, B2M
 28
GOBP_REGULATION_OF_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION 8.35e-04 57.69 5.91 1.18e-01 1.00e+00
2SLC11A1, CD68
 11
GOBP_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_OXIDATIVE_STRESS 8.35e-04 57.69 5.91 1.18e-01 1.00e+00
2HMOX1, HIF1A
 11
GOBP_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS 8.35e-04 57.69 5.91 1.18e-01 1.00e+00
2APOE, LAPTM5
 11
GOBP_SECRETION 2.58e-14 10.23 5.63 1.93e-10 1.93e-10
27SPP1, APOE, CTSD, CTSB, CTSZ, SLC2A3, SLC11A1, HMOX1, ITGAX, IL1RN, SLC16A10, PLAUR, CD109, TYROBP, PSAP, CD14, CSTB, ITGB2, RAB31, CD68, SRGN, PAM, FCER1G, GNAS, HIF1A, B2M, HK2
 1464
GOBP_NEGATIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION 9.99e-04 51.89 5.39 1.31e-01 1.00e+00
2APOE, TYROBP
 12
GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 4.94e-11 10.00 5.26 1.23e-07 3.69e-07
18CTSD, CTSB, CTSZ, SLC2A3, SLC11A1, HMOX1, ITGAX, PLAUR, TYROBP, PSAP, CD14, TFRC, CSTB, ITGB2, RAB31, CD68, FCER1G, B2M
 722
GOBP_MYELOID_LEUKOCYTE_ACTIVATION 1.26e-10 10.04 5.21 2.14e-07 9.44e-07
17CTSD, CTSB, CTSZ, SLC2A3, SLC11A1, HMOX1, ITGAX, PLAUR, TYROBP, PSAP, CD14, CSTB, ITGB2, RAB31, CD68, FCER1G, B2M
 659
GOBP_IRON_ION_HOMEOSTASIS 2.16e-05 17.14 5.17 1.35e-02 1.62e-01
5SLC11A1, HMOX1, TFRC, HIF1A, B2M
 86
GOBP_PHOSPHOLIPID_EFFLUX 1.18e-03 47.19 4.96 1.36e-01 1.00e+00
2APOE, APOC1
 13

Dowload full table

Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE29618_MONOCYTE_VS_PDC_UP 1.85e-14 26.27 12.86 4.82e-11 8.99e-11
14NEAT1, SLC2A3, HMOX1, ITGAX, IL1RN, TYROBP, CD14, ITGB2, RAB31, S100A10, S100A4, RAB20, HIF1A, HK2
 199
GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_DN 1.98e-14 26.13 12.79 4.82e-11 9.64e-11
14CTSD, CTSB, SLC11A1, HMOX1, IL1RN, PLAUR, TYROBP, PSAP, ARHGAP26, TGFBI, RAB31, S100A4, FCER1G, HK2
 200
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 5.03e-13 23.47 11.26 4.90e-10 2.45e-09
13CTSD, CTSB, SLC11A1, HMOX1, ITGAX, IL1RN, PLAUR, TYROBP, PSAP, CD14, TGFBI, RAB31, FCER1G
 200
GSE22886_NAIVE_BCELL_VS_MONOCYTE_DN 5.03e-13 23.47 11.26 4.90e-10 2.45e-09
13CTSD, CTSB, SLC11A1, CAPG, TYROBP, PSAP, CD14, SLC16A3, RAB31, S100A10, SRGN, S100A4, FCER1G
 200
GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN 5.03e-13 23.47 11.26 4.90e-10 2.45e-09
13CTSB, SLC11A1, HMOX1, CAPG, LAPTM5, TYROBP, PSAP, CD14, ARHGAP26, TGFBI, SLC16A3, RAB31, FCER1G
 200
GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_DN 1.15e-11 20.99 9.83 8.00e-09 5.60e-08
12SPP1, APOC1, CTSB, CTSZ, HMOX1, ITGAX, CAPG, TYROBP, PSAP, CD14, ITGB2, RAB31
 200
GSE29618_MONOCYTE_VS_MDC_UP 1.15e-11 20.99 9.83 8.00e-09 5.60e-08
12CTSD, CTSB, SLC11A1, HMOX1, TYROBP, PSAP, CD14, CD68, S100A4, FCER1G, HIF1A, ELL2
 200
GSE24634_TEFF_VS_TCONV_DAY10_IN_CULTURE_DN 2.35e-10 18.65 8.48 1.43e-07 1.15e-06
11SPP1, CTSZ, SLC11A1, ITGAX, GPNMB, CAPG, PSAP, ZEB2, ITGB2, RAB31, FCER1G
 200
GSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_UP 3.72e-09 16.71 7.34 1.74e-06 1.81e-05
10CTSD, CTSZ, SLC11A1, HMOX1, CAPG, TYROBP, PSAP, CD14, TGFBI, RAB31
 197
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_DN 3.90e-09 16.62 7.30 1.74e-06 1.90e-05
10MMP12, ACP5, CTSB, CTSZ, PLAUR, TYROBP, PSAP, CD14, CD68, RAB20
 198
GSE6269_FLU_VS_STAPH_AUREUS_INF_PBMC_DN 1.48e-08 17.36 7.29 5.54e-06 7.21e-05
9CTSD, CTSB, SLC11A1, IL1RN, PLAUR, S100A10, SRGN, RAB20, HIF1A
 167
GSE29618_BCELL_VS_MDC_DN 4.29e-09 16.45 7.22 1.74e-06 2.09e-05
10CTSB, ITGAX, CAPG, RGS1, TGFBI, CSTB, ITGB2, RAB31, S100A10, S100A4
 200
GSE29618_PDC_VS_MDC_DN 4.29e-09 16.45 7.22 1.74e-06 2.09e-05
10SLC2A3, ITGAX, IL1RN, CSTB, ITGB2, RAB31, S100A10, S100A4, HIF1A, HK2
 200
GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_UP 6.34e-08 14.52 6.11 1.53e-05 3.09e-04
9SPP1, SLC2A3, PLAUR, MMP19, RGS1, TFRC, RAB20, RREB1, ELL2
 198
GSE10325_BCELL_VS_MYELOID_DN 6.91e-08 14.37 6.05 1.53e-05 3.36e-04
9CTSB, SLC11A1, HMOX1, IL1RN, PLAUR, PSAP, TGFBI, SRGN, S100A4
 200
GSE17721_ALL_VS_24H_PAM3CSK4_BMDC_UP 6.91e-08 14.37 6.05 1.53e-05 3.36e-04
9SPP1, APOE, MITF, CTSB, ITGAX, IL1RN, CAPG, PLAUR, PSAP
 200
GSE29618_BCELL_VS_MONOCYTE_DN 6.91e-08 14.37 6.05 1.53e-05 3.36e-04
9CTSB, HMOX1, PLAUR, PSAP, CD14, ITGB2, RAB31, CD68, RAB20
 200
GSE29618_BCELL_VS_MONOCYTE_DAY7_FLU_VACCINE_DN 6.91e-08 14.37 6.05 1.53e-05 3.36e-04
9CTSD, HMOX1, IL1RN, PLAUR, TYROBP, PSAP, CD14, CD68, RAB20
 200
GSE29618_BCELL_VS_MDC_DAY7_FLU_VACCINE_DN 6.91e-08 14.37 6.05 1.53e-05 3.36e-04
9ITGAX, IL1RN, TYROBP, PSAP, TGFBI, RAB31, S100A10, S100A4, FCER1G
 200
GSE3337_CTRL_VS_16H_IFNG_IN_CD8POS_DC_UP 6.91e-08 14.37 6.05 1.53e-05 3.36e-04
9MMP12, APOE, CTSD, ACP5, CTSB, HMOX1, TYROBP, CD14, S100A4
 200

Dowload full table

Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MITF 7 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Binds DNA both as homo- and heterodimers (PMID: 23207919). The structure 4ATI is a homodimer with DNA GTTAGCACATGACCCT.
HMOX1 13 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Well characterized enzyme with no additional domains. Included only because GO lists it as a regulator of TFs. No support for DNA binding activity.
ZEB2 33 Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None
ITGB2 35 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HIF1A 46 Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds as obligate heteromer with ARNT (PMID: 9027737).
RREB1 47 Yes Known motif Monomer or homomultimer In vivo/Misc source None None
SGK1 58 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RGCC 64 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MEIS1 67 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CEBPB 71 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PLXNA4 95 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade (PMID: 12591607).
CAMK2A 99 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZBTB20 131 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
SPI1 132 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TSHZ2 134 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Also contains an atypical homodomain (Uniprot) not identified by Pfam.
SORBS2 139 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZFP36L1 140 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 27102483; PMID: 17013884).
AFF1 157 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook MLL fusion partner
LPP 159 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None znfLIM is probably not a DNA binding domain (PMID: 8506279). The protein has been reported to be coactivator for ETV4 (PMID: 16738319).
ATF3 185 Yes Known motif Monomer or homomultimer High-throughput in vitro None None

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB09_ACTGATGGTTGGTAAA-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.11 808.25
Raw ScoresMacrophage:monocyte-derived: 0.29, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.28, Macrophage:monocyte-derived:M-CSF: 0.28, Macrophage:monocyte-derived:IL-4/cntrl: 0.28, Macrophage:monocyte-derived:IL-4/TGFb: 0.28, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.28, Macrophage:monocyte-derived:S._aureus: 0.28, Monocyte:CXCL4: 0.28, DC:monocyte-derived:AM580: 0.28, Macrophage:monocyte-derived:IFNa: 0.28
NB09_GTGAAGGAGTACGTTC-1 Neurons:adrenal_medulla_cell_line 0.06 624.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Macrophage:monocyte-derived: 0.2, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.2, Monocyte:CXCL4: 0.2, Macrophage:monocyte-derived:IL-4/cntrl: 0.2, Macrophage:monocyte-derived:IL-4/TGFb: 0.2, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, Monocyte:MCSF: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IFNa: 0.19
NB09_TCTATTGAGATGAGAG-1 Macrophage:Alveolar 0.04 544.86
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.19, DC:monocyte-derived:Galectin-1: 0.19, Macrophage:monocyte-derived:S._aureus: 0.18, Macrophage:Alveolar:B._anthacis_spores: 0.18, Macrophage:monocyte-derived: 0.18, DC:monocyte-derived:AEC-conditioned: 0.18, Macrophage:Alveolar: 0.18, DC:monocyte-derived:mature: 0.18, Macrophage:monocyte-derived:IFNa: 0.18, DC:monocyte-derived:CD40L: 0.18
NB09_CTGAAACCAAAGCAAT-1 Neurons:adrenal_medulla_cell_line 0.12 481.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, Endothelial_cells:HUVEC:VEGF: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.25, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.25, Endothelial_cells:HUVEC: 0.24, Endothelial_cells:lymphatic: 0.24, Endothelial_cells:lymphatic:TNFa_48h: 0.24, Endothelial_cells:blood_vessel: 0.23
NB09_GTCGTAAAGGCGTACA-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.04 472.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.23, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.23, Macrophage:monocyte-derived: 0.23, Macrophage:monocyte-derived:M-CSF: 0.23, DC:monocyte-derived:immature: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.22, Macrophage:monocyte-derived:IL-4/TGFb: 0.22, Neurons:Schwann_cell: 0.22, Macrophage:monocyte-derived:IL-4/cntrl: 0.22
NB09_ACGGCCAAGCGATCCC-1 Macrophage:monocyte-derived 0.07 452.88
Raw ScoresMacrophage:monocyte-derived: 0.22, DC:monocyte-derived: 0.22, DC:monocyte-derived:AM580: 0.22, Macrophage:monocyte-derived:IL-4/TGFb: 0.22, Macrophage:monocyte-derived:IL-4/cntrl: 0.22, DC:monocyte-derived:AEC-conditioned: 0.22, DC:monocyte-derived:immature: 0.22, Macrophage:monocyte-derived:S._aureus: 0.22, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.22, DC:monocyte-derived:anti-DC-SIGN_2h: 0.22
NB09_TCAGATGAGACTACAA-1 Neurons:adrenal_medulla_cell_line 0.08 433.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Endothelial_cells:HUVEC:VEGF: 0.15, Macrophage:monocyte-derived:M-CSF: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, Monocyte:MCSF: 0.15, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15
NB09_AGGGTGAGTTATCACG-1 Macrophage:monocyte-derived 0.10 394.29
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.25, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.25, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.25, DC:monocyte-derived:anti-DC-SIGN_2h: 0.24, Macrophage:monocyte-derived:IL-4/cntrl: 0.24, Macrophage:monocyte-derived:IL-4/TGFb: 0.24, Macrophage:monocyte-derived:M-CSF/IFNg: 0.23, DC:monocyte-derived: 0.23, Monocyte:leukotriene_D4: 0.23, Macrophage:monocyte-derived: 0.23
NB09_GCGCAGTTCCTTAATC-1 Neurons:adrenal_medulla_cell_line 0.06 389.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Fibroblasts:breast: 0.17, Chondrocytes:MSC-derived: 0.17, Smooth_muscle_cells:bronchial:vit_D: 0.17, Smooth_muscle_cells:bronchial: 0.17, Tissue_stem_cells:BM_MSC:TGFb3: 0.16, Osteoblasts: 0.16, Smooth_muscle_cells:vascular: 0.16, Smooth_muscle_cells:vascular:IL-17: 0.16, iPS_cells:CRL2097_foreskin: 0.16
NB13_TGACGGCGTCTTGTCC-1 Macrophage:monocyte-derived 0.05 371.23
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.19, Macrophage:monocyte-derived: 0.19, Macrophage:monocyte-derived:S._aureus: 0.19, Macrophage:monocyte-derived:IL-4/cntrl: 0.19, DC:monocyte-derived:AEC-conditioned: 0.19, Macrophage:monocyte-derived:IL-4/TGFb: 0.18, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.18, Macrophage:Alveolar:B._anthacis_spores: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, DC:monocyte-derived:AM580: 0.18
NB09_CGATTGAGTTTGTTGG-1 Neurons:adrenal_medulla_cell_line 0.10 356.34
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_2lox-22: 0.18
NB09_TCACAAGAGCTAAACA-1 Macrophage:monocyte-derived 0.05 347.67
Raw ScoresMacrophage:monocyte-derived: 0.22, Macrophage:monocyte-derived:M-CSF: 0.22, Macrophage:monocyte-derived:S._aureus: 0.22, Monocyte:MCSF: 0.22, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.22, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.22, DC:monocyte-derived: 0.22, DC:monocyte-derived:Galectin-1: 0.22, Macrophage:monocyte-derived:IFNa: 0.22, DC:monocyte-derived:immature: 0.21
NB09_AAGGCAGTCTTCATGT-1 Neurons:adrenal_medulla_cell_line 0.08 340.90
Raw ScoresAstrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, Endothelial_cells:HUVEC:VEGF: 0.21, iPS_cells:CRL2097_foreskin: 0.21, Endothelial_cells:lymphatic: 0.21, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.2, Endothelial_cells:lymphatic:TNFa_48h: 0.2, Endothelial_cells:HUVEC: 0.2
NB09_TGCACCTGTAGAAGGA-1 Macrophage:monocyte-derived 0.02 323.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neuroepithelial_cell:ESC-derived: 0.18, Macrophage:monocyte-derived: 0.17, Chondrocytes:MSC-derived: 0.17, Tissue_stem_cells:BM_MSC:BMP2: 0.17, Macrophage:monocyte-derived:S._aureus: 0.17, Tissue_stem_cells:BM_MSC:TGFb3: 0.17, Smooth_muscle_cells:vascular: 0.17, DC:monocyte-derived:mature: 0.17
NB09_TAGCCGGTCACTCTTA-1 Monocyte:CXCL4 0.06 320.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Macrophage:monocyte-derived: 0.18, Monocyte:CXCL4: 0.18, Monocyte:MCSF: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.18, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18
NB09_GCAATCATCTTCAACT-1 Neurons:adrenal_medulla_cell_line 0.07 310.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neuroepithelial_cell:ESC-derived: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, DC:monocyte-derived:AEC-conditioned: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, DC:monocyte-derived: 0.17
NB09_GAGGTGAGTGAAATCA-1 Macrophage:monocyte-derived 0.04 268.55
Raw ScoresMacrophage:monocyte-derived: 0.18, Macrophage:monocyte-derived:S._aureus: 0.18, Tissue_stem_cells:BM_MSC:BMP2: 0.18, Monocyte:MCSF: 0.18, Macrophage:monocyte-derived:IFNa: 0.18, Tissue_stem_cells:BM_MSC: 0.18, Monocyte:CXCL4: 0.18, Tissue_stem_cells:BM_MSC:TGFb3: 0.18, DC:monocyte-derived:AEC-conditioned: 0.17, Tissue_stem_cells:BM_MSC:osteogenic: 0.17
NB09_GAACCTAGTTGTCTTT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.08 266.32
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.16, Macrophage:monocyte-derived:M-CSF: 0.16, DC:monocyte-derived:immature: 0.16, DC:monocyte-derived:Schuler_treatment: 0.16, DC:monocyte-derived: 0.16, Monocyte: 0.16, Macrophage:monocyte-derived:IL-4/cntrl: 0.16, Monocyte:S._typhimurium_flagellin: 0.16
NB09_ACGGGCTGTGCGAAAC-1 Neurons:adrenal_medulla_cell_line 0.09 262.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.15, Embryonic_stem_cells: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, Neurons:Schwann_cell: 0.15
NB09_AACTCCCAGAAGATTC-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.04 258.79
Raw ScoresDC:monocyte-derived:immature: 0.15, Macrophage:monocyte-derived:M-CSF: 0.15, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15, DC:monocyte-derived:anti-DC-SIGN_2h: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.15, DC:monocyte-derived: 0.15, DC:monocyte-derived:Schuler_treatment: 0.15, DC:monocyte-derived:antiCD40/VAF347: 0.15, Macrophage:monocyte-derived:IL-4/TGFb: 0.15, Macrophage:monocyte-derived:IL-4/cntrl: 0.15
NB09_CCAGCGAGTATCACCA-1 Macrophage:monocyte-derived 0.06 253.31
Raw ScoresMacrophage:monocyte-derived: 0.19, Monocyte:MCSF: 0.19, Monocyte:CXCL4: 0.18, Macrophage:Alveolar: 0.18, Macrophage:monocyte-derived:S._aureus: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.18, Macrophage:Alveolar:B._anthacis_spores: 0.18, DC:monocyte-derived:immature: 0.18, Macrophage:monocyte-derived:IFNa: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18
NB09_CTTGGCTCAGCTGGCT-1 Neurons:adrenal_medulla_cell_line 0.02 246.42
Raw ScoresAstrocyte:Embryonic_stem_cell-derived: 0.15, DC:monocyte-derived:AEC-conditioned: 0.14, Macrophage:monocyte-derived: 0.14, Macrophage:monocyte-derived:S._aureus: 0.14, Neurons:adrenal_medulla_cell_line: 0.14, DC:monocyte-derived:mature: 0.14, DC:monocyte-derived:rosiglitazone/AGN193109: 0.14, DC:monocyte-derived:AM580: 0.14, DC:monocyte-derived:immature: 0.14, Monocyte:MCSF: 0.14
NB09_CTAACTTGTCACTTCC-1 Macrophage:monocyte-derived:M-CSF 0.08 242.53
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.2, DC:monocyte-derived:anti-DC-SIGN_2h: 0.2, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Macrophage:monocyte-derived: 0.19, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, Macrophage:monocyte-derived:S._aureus: 0.19, DC:monocyte-derived:immature: 0.19, Macrophage:monocyte-derived:IFNa: 0.19, Monocyte:leukotriene_D4: 0.19, Monocyte: 0.19
NB09_GATCGTAAGCTGAACG-1 Macrophage:monocyte-derived 0.04 242.07
Raw ScoresMonocyte:MCSF: 0.18, Monocyte:CXCL4: 0.17, Macrophage:monocyte-derived: 0.17, Macrophage:monocyte-derived:S._aureus: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, Macrophage:monocyte-derived:IL-4/cntrl: 0.17, Macrophage:monocyte-derived:IL-4/TGFb: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, Macrophage:Alveolar: 0.17, Macrophage:monocyte-derived:IFNa: 0.16
NB09_CAGAGAGCATCAGTAC-1 Neurons:adrenal_medulla_cell_line 0.08 233.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:CRL2097_foreskin: 0.14, Embryonic_stem_cells: 0.14, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.14, Macrophage:monocyte-derived:M-CSF: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13
NB09_GTCTTCGTCCTCGCAT-1 Monocyte:CXCL4 0.07 231.95
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.18, DC:monocyte-derived:Schuler_treatment: 0.18, Macrophage:monocyte-derived:M-CSF: 0.18, Macrophage:monocyte-derived: 0.18, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.18, DC:monocyte-derived:antiCD40/VAF347: 0.18, Macrophage:Alveolar: 0.18, Macrophage:monocyte-derived:IFNa: 0.18, Macrophage:Alveolar:B._anthacis_spores: 0.18, Monocyte:CXCL4: 0.18
NB09_AAGGTTCGTGCTCTTC-1 DC:monocyte-derived:antiCD40/VAF347 0.08 224.84
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.17, Macrophage:monocyte-derived:S._aureus: 0.17, DC:monocyte-derived:Galectin-1: 0.17, DC:monocyte-derived:Schuler_treatment: 0.17, DC:monocyte-derived:antiCD40/VAF347: 0.17, DC:monocyte-derived:LPS: 0.16, DC:monocyte-derived: 0.16, Monocyte:leukotriene_D4: 0.16, Monocyte:anti-FcgRIIB: 0.16, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.16
NB09_CTCGTCATCGGCGGTT-1 Neurons:adrenal_medulla_cell_line 0.19 215.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.18, Embryonic_stem_cells: 0.18, iPS_cells:PDB_2lox-22: 0.18
NB09_TGACTTTAGACTGGGT-1 Neurons:adrenal_medulla_cell_line 0.11 215.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:skin_fibroblast-derived: 0.13
NB09_TGAGCATGTCACACGC-1 Neurons:adrenal_medulla_cell_line 0.19 213.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:skin_fibroblast-derived: 0.18
NB14_TTTGCGCTCGAACTGT-1 Monocyte:MCSF 0.07 200.97
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, Monocyte:MCSF: 0.17, Macrophage:monocyte-derived: 0.17, Macrophage:monocyte-derived:M-CSF: 0.17, Monocyte:CXCL4: 0.17, Macrophage:monocyte-derived:IL-4/TGFb: 0.17, Macrophage:monocyte-derived:IL-4/cntrl: 0.17, Macrophage:monocyte-derived:S._aureus: 0.16, Macrophage:monocyte-derived:IFNa: 0.16
NB09_ACGAGCCGTTCACGGC-1 Macrophage:monocyte-derived 0.06 190.16
Raw ScoresMacrophage:monocyte-derived: 0.2, Monocyte:MCSF: 0.2, Monocyte:CXCL4: 0.19, Macrophage:monocyte-derived:IFNa: 0.19, Macrophage:monocyte-derived:S._aureus: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Macrophage:monocyte-derived:IL-4/TGFb: 0.19, Macrophage:monocyte-derived:IL-4/cntrl: 0.19, DC:monocyte-derived:AM580: 0.19, DC:monocyte-derived:rosiglitazone: 0.19
NB09_CCTTCGACATTTGCTT-1 Neurons:adrenal_medulla_cell_line 0.20 189.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_2lox-22: 0.18
NB09_CTACCCAGTGAGTATA-1 Macrophage:monocyte-derived 0.03 187.10
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Monocyte:MCSF: 0.16, Macrophage:monocyte-derived: 0.16, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.16, Macrophage:monocyte-derived:M-CSF: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Monocyte:CXCL4: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.15, Macrophage:monocyte-derived:IL-4/cntrl: 0.15, Macrophage:monocyte-derived:IL-4/TGFb: 0.15
NB09_GTGCATACAGTCTTCC-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.04 176.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, Macrophage:monocyte-derived:M-CSF: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.16, DC:monocyte-derived:anti-DC-SIGN_2h: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.15, Monocyte:leukotriene_D4: 0.15, Neuroepithelial_cell:ESC-derived: 0.15, DC:monocyte-derived:immature: 0.15, DC:monocyte-derived: 0.15
NB09_AGCATACAGTACGCCC-1 Neurons:adrenal_medulla_cell_line 0.06 172.06
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neuroepithelial_cell:ESC-derived: 0.13, Neurons:ES_cell-derived_neural_precursor: 0.13, Embryonic_stem_cells: 0.12, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.11, Smooth_muscle_cells:bronchial: 0.11, Smooth_muscle_cells:bronchial:vit_D: 0.11, DC:monocyte-derived:anti-DC-SIGN_2h: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.11
NB09_CAGCTGGAGTTGAGTA-1 Neurons:adrenal_medulla_cell_line 0.06 170.80
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.13, Astrocyte:Embryonic_stem_cell-derived: 0.13, Neurons:ES_cell-derived_neural_precursor: 0.12, iPS_cells:CRL2097_foreskin: 0.12, Endothelial_cells:HUVEC:VEGF: 0.11, MSC: 0.11, Embryonic_stem_cells: 0.11, Endothelial_cells:HUVEC: 0.11, iPS_cells:skin_fibroblast: 0.11
NB09_GCCTCTATCATGCATG-1 Neurons:adrenal_medulla_cell_line 0.10 169.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.12, Embryonic_stem_cells: 0.12, Neurons:Schwann_cell: 0.12
NB09_AGATTGCCACACCGCA-1 Neurons:adrenal_medulla_cell_line 0.21 168.21
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_2lox-22: 0.22
NB09_TCAGGTAAGATCACGG-1 Tissue_stem_cells:BM_MSC:TGFb3 0.04 163.20
Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.16, Tissue_stem_cells:BM_MSC:BMP2: 0.16, Smooth_muscle_cells:vascular: 0.15, DC:monocyte-derived:mature: 0.15, Fibroblasts:breast: 0.15, iPS_cells:adipose_stem_cells: 0.15, Tissue_stem_cells:BM_MSC: 0.15, DC:monocyte-derived:Schuler_treatment: 0.15, Tissue_stem_cells:BM_MSC:osteogenic: 0.15, Smooth_muscle_cells:vascular:IL-17: 0.15
NB09_TGCTGCTAGTTATCGC-1 Neurons:adrenal_medulla_cell_line 0.13 156.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, Embryonic_stem_cells: 0.15, iPS_cells:skin_fibroblast-derived: 0.14
NB09_ACGCCAGTCTCTGCTG-1 Neurons:adrenal_medulla_cell_line 0.07 155.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.12, Astrocyte:Embryonic_stem_cell-derived: 0.1, Neuroepithelial_cell:ESC-derived: 0.1, Neurons:ES_cell-derived_neural_precursor: 0.1, Embryonic_stem_cells: 0.08, iPS_cells:PDB_1lox-17Puro-10: 0.08, Macrophage:monocyte-derived: 0.08, iPS_cells:skin_fibroblast-derived: 0.08, iPS_cells:PDB_1lox-21Puro-20: 0.08, iPS_cells:PDB_1lox-21Puro-26: 0.08
NB09_GGGAGATGTGTCTGAT-1 Monocyte:CXCL4 0.04 152.55
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.14, Macrophage:monocyte-derived: 0.14, DC:monocyte-derived:Schuler_treatment: 0.14, Macrophage:monocyte-derived:IL-4/cntrl: 0.14, DC:monocyte-derived:AM580: 0.14, DC:monocyte-derived: 0.14, Macrophage:monocyte-derived:IL-4/TGFb: 0.14, DC:monocyte-derived:rosiglitazone: 0.14, DC:monocyte-derived:CD40L: 0.14
NB09_CACAGTAGTCATCGGC-1 Macrophage:monocyte-derived:M-CSF 0.06 152.43
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.17, DC:monocyte-derived:antiCD40/VAF347: 0.17, Monocyte:S._typhimurium_flagellin: 0.17, Macrophage:monocyte-derived:M-CSF: 0.17, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, DC:monocyte-derived: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, DC:monocyte-derived:immature: 0.16, Monocyte:anti-FcgRIIB: 0.16
NB09_CTGATCCGTCCTCCAT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.08 148.74
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:S._aureus: 0.19, DC:monocyte-derived:LPS: 0.18, Macrophage:monocyte-derived: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18, DC:monocyte-derived:Galectin-1: 0.18, Macrophage:Alveolar: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18
NB09_AAGACCTGTTCAACCA-1 Neurons:adrenal_medulla_cell_line 0.17 147.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:PDB_2lox-22: 0.18
NB09_GCGACCACATCCTTGC-1 Monocyte:MCSF 0.04 145.94
Raw ScoresMacrophage:monocyte-derived: 0.16, Monocyte:MCSF: 0.16, Macrophage:monocyte-derived:S._aureus: 0.16, Macrophage:monocyte-derived:M-CSF: 0.16, Monocyte:CXCL4: 0.16, Neurons:adrenal_medulla_cell_line: 0.15, Macrophage:monocyte-derived:IL-4/cntrl: 0.15, Macrophage:monocyte-derived:IFNa: 0.15, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15, Macrophage:monocyte-derived:IL-4/TGFb: 0.15
NB09_GGAGCAAGTTGTCGCG-1 Neurons:adrenal_medulla_cell_line 0.18 145.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:PDB_2lox-22: 0.17
NB06_GGAATAAGTGACGGTA-1 Neurons:adrenal_medulla_cell_line 0.18 144.53
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neuroepithelial_cell:ESC-derived: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.29, Neurons:Schwann_cell: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.27, MSC: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, Tissue_stem_cells:CD326-CD56+: 0.27
NB09_GGCGACTGTAAATACG-1 Neurons:adrenal_medulla_cell_line 0.10 144.32
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.27, Endothelial_cells:lymphatic: 0.27, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.26, Endothelial_cells:HUVEC: 0.26, Endothelial_cells:blood_vessel: 0.26, Endothelial_cells:HUVEC:B._anthracis_LT: 0.25, Endothelial_cells:lymphatic:KSHV: 0.25, Endothelial_cells:HUVEC:IL-1b: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.48e-03
Mean rank of genes in gene set: 3497.13
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD14 0.0064117 28 GTEx DepMap Descartes 0.23 346.68
HIF1A 0.0052630 46 GTEx DepMap Descartes 1.00 580.88
CD84 0.0020188 275 GTEx DepMap Descartes 0.07 17.93
CD36 0.0019174 301 GTEx DepMap Descartes 0.16 64.74
VEGFA 0.0015821 403 GTEx DepMap Descartes 0.23 47.35
TNFRSF10B 0.0010751 682 GTEx DepMap Descartes 0.08 37.38
STAT3 0.0008034 970 GTEx DepMap Descartes 0.49 181.26
CD274 0.0003768 2093 GTEx DepMap Descartes 0.01 6.67
IL10 0.0003377 2283 GTEx DepMap Descartes 0.00 9.75
TGFB1 0.0003204 2369 GTEx DepMap Descartes 0.11 77.81
ARG1 0.0000640 4564 GTEx DepMap Descartes 0.00 0.00
NOS2 -0.0000598 6589 GTEx DepMap Descartes 0.00 0.00
TNF -0.0002312 9841 GTEx DepMap Descartes 0.01 1.28
IL1B -0.0002564 10187 GTEx DepMap Descartes 0.00 0.00
ARG2 -0.0004816 11826 GTEx DepMap Descartes 0.05 23.35


M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.18e-03
Mean rank of genes in gene set: 2372.29
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD14 0.0064117 28 GTEx DepMap Descartes 0.23 346.68
CD163 0.0020899 259 GTEx DepMap Descartes 0.06 33.40
VEGFA 0.0015821 403 GTEx DepMap Descartes 0.23 47.35
IL10 0.0003377 2283 GTEx DepMap Descartes 0.00 9.75
TGFB1 0.0003204 2369 GTEx DepMap Descartes 0.11 77.81
ARG1 0.0000640 4564 GTEx DepMap Descartes 0.00 0.00
IL13 -0.0000644 6700 GTEx DepMap Descartes 0.00 0.00


Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.37e-03
Mean rank of genes in gene set: 367.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
S100A10 0.0059398 39 GTEx DepMap Descartes 0.18 593.98
B2M 0.0051099 49 GTEx DepMap Descartes 2.15 1602.43
IFITM3 0.0007768 1014 GTEx DepMap Descartes 0.15 383.19




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8191.66
Median rank of genes in gene set: 9776
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HK2 0.0051072 50 GTEx DepMap Descartes 0.16 70.90
CELF2 0.0035526 100 GTEx DepMap Descartes 0.70 188.22
RNF144A 0.0034976 101 GTEx DepMap Descartes 0.96 327.39
MIAT 0.0026276 168 GTEx DepMap Descartes 1.58 307.58
CADM1 0.0024818 181 GTEx DepMap Descartes 3.56 781.33
RBMS3 0.0023204 205 GTEx DepMap Descartes 4.50 1042.24
TH 0.0020128 276 GTEx DepMap Descartes 1.42 1389.19
DAPK1 0.0020090 277 GTEx DepMap Descartes 0.54 188.27
CXCR4 0.0018317 329 GTEx DepMap Descartes 0.15 167.51
LYN 0.0018138 331 GTEx DepMap Descartes 0.20 92.22
NELFCD 0.0014609 448 GTEx DepMap Descartes 0.42 NA
MYO5A 0.0014342 457 GTEx DepMap Descartes 0.48 76.66
TMOD1 0.0014307 460 GTEx DepMap Descartes 1.00 616.00
DPYSL3 0.0013355 512 GTEx DepMap Descartes 0.91 278.24
DNER 0.0012494 556 GTEx DepMap Descartes 0.28 186.35
NRCAM 0.0012120 580 GTEx DepMap Descartes 1.03 288.94
PIK3R1 0.0011990 591 GTEx DepMap Descartes 0.37 121.10
SCN3A 0.0011677 617 GTEx DepMap Descartes 0.95 195.19
UCP2 0.0010599 699 GTEx DepMap Descartes 0.09 112.39
RIMBP2 0.0009828 773 GTEx DepMap Descartes 1.18 366.53
ATP6V1B2 0.0009536 802 GTEx DepMap Descartes 0.30 100.73
FAM155A 0.0007808 1008 GTEx DepMap Descartes 5.27 1042.38
IGSF3 0.0007237 1097 GTEx DepMap Descartes 0.19 62.91
OLFM1 0.0006957 1150 GTEx DepMap Descartes 0.09 57.00
KIDINS220 0.0006619 1212 GTEx DepMap Descartes 0.86 204.60
TIAM1 0.0006491 1234 GTEx DepMap Descartes 0.70 200.19
EYA1 0.0006273 1290 GTEx DepMap Descartes 0.97 431.13
RALGDS 0.0006197 1307 GTEx DepMap Descartes 0.33 115.78
CHGB 0.0005687 1427 GTEx DepMap Descartes 1.03 797.23
GCH1 0.0005255 1535 GTEx DepMap Descartes 0.39 246.38


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.00e-20
Mean rank of genes in gene set: 4706.94
Median rank of genes in gene set: 3929
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOE 0.0162972 3 GTEx DepMap Descartes 2.06 4173.35
CTSB 0.0097785 8 GTEx DepMap Descartes 1.21 829.79
RAB31 0.0060777 37 GTEx DepMap Descartes 0.36 219.44
B2M 0.0051099 49 GTEx DepMap Descartes 2.15 1602.43
PLXDC2 0.0050156 51 GTEx DepMap Descartes 1.09 190.33
GSN 0.0049645 52 GTEx DepMap Descartes 0.33 112.83
SGK1 0.0047055 58 GTEx DepMap Descartes 0.40 185.34
ATP2B4 0.0045771 61 GTEx DepMap Descartes 0.99 214.21
FNDC3B 0.0042244 70 GTEx DepMap Descartes 0.85 216.86
ROBO1 0.0041205 74 GTEx DepMap Descartes 4.85 1277.19
ANXA2 0.0040949 75 GTEx DepMap Descartes 0.43 276.41
NPC2 0.0038278 86 GTEx DepMap Descartes 0.18 321.18
CBLB 0.0036777 92 GTEx DepMap Descartes 0.78 266.54
LGALS1 0.0034159 105 GTEx DepMap Descartes 0.40 1035.16
VIM 0.0034057 106 GTEx DepMap Descartes 0.66 521.78
GRN 0.0032178 111 GTEx DepMap Descartes 0.30 285.42
PAPSS2 0.0031211 118 GTEx DepMap Descartes 0.18 107.17
ZFP36L1 0.0029651 140 GTEx DepMap Descartes 0.36 274.52
LPP 0.0027199 159 GTEx DepMap Descartes 1.20 130.35
COL6A2 0.0027115 162 GTEx DepMap Descartes 0.51 285.31
IQGAP2 0.0026136 170 GTEx DepMap Descartes 0.26 87.90
ANXA5 0.0025844 173 GTEx DepMap Descartes 0.24 315.05
LITAF 0.0025746 174 GTEx DepMap Descartes 0.30 263.34
ANXA1 0.0025626 176 GTEx DepMap Descartes 0.24 273.96
NRP1 0.0024564 186 GTEx DepMap Descartes 0.97 289.20
NR3C1 0.0023909 196 GTEx DepMap Descartes 0.46 124.71
TNS1 0.0022746 216 GTEx DepMap Descartes 0.11 22.16
PLSCR1 0.0021841 237 GTEx DepMap Descartes 0.16 226.29
GPR137B 0.0021529 241 GTEx DepMap Descartes 0.15 193.27
SDC2 0.0020560 267 GTEx DepMap Descartes 0.14 63.59


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.56e-01
Mean rank of genes in gene set: 6359.42
Median rank of genes in gene set: 6579.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOC1 0.0140010 4 GTEx DepMap Descartes 1.35 4965.71
PAPSS2 0.0031211 118 GTEx DepMap Descartes 0.18 107.17
SH3BP5 0.0017280 356 GTEx DepMap Descartes 0.19 109.91
DNER 0.0012494 556 GTEx DepMap Descartes 0.28 186.35
NPC1 0.0009179 844 GTEx DepMap Descartes 0.24 94.68
FDX1 0.0008848 878 GTEx DepMap Descartes 0.06 42.37
SH3PXD2B 0.0005938 1373 GTEx DepMap Descartes 0.19 43.26
CLU 0.0003594 2170 GTEx DepMap Descartes 0.38 220.10
SCARB1 0.0002945 2488 GTEx DepMap Descartes 0.09 30.38
PEG3 0.0002790 2584 GTEx DepMap Descartes 0.26 NA
IGF1R 0.0002134 3034 GTEx DepMap Descartes 0.77 102.70
ERN1 0.0002111 3047 GTEx DepMap Descartes 0.06 12.91
JAKMIP2 0.0001999 3141 GTEx DepMap Descartes 0.40 85.78
SCAP 0.0001326 3770 GTEx DepMap Descartes 0.14 65.95
DHCR24 0.0000606 4616 GTEx DepMap Descartes 0.08 29.01
INHA 0.0000392 4911 GTEx DepMap Descartes 0.00 0.79
GRAMD1B -0.0000193 5810 GTEx DepMap Descartes 0.07 12.07
FREM2 -0.0000422 6234 GTEx DepMap Descartes 0.00 0.00
BAIAP2L1 -0.0000763 6925 GTEx DepMap Descartes 0.02 4.60
STAR -0.0000985 7374 GTEx DepMap Descartes 0.00 0.00
POR -0.0001309 8070 GTEx DepMap Descartes 0.06 37.80
DHCR7 -0.0001575 8627 GTEx DepMap Descartes 0.02 4.09
GSTA4 -0.0001760 8950 GTEx DepMap Descartes 0.14 145.61
FDXR -0.0001857 9114 GTEx DepMap Descartes 0.01 5.78
FRMD5 -0.0002434 10018 GTEx DepMap Descartes 0.75 263.22
TM7SF2 -0.0002480 10073 GTEx DepMap Descartes 0.06 48.21
HMGCS1 -0.0002661 10303 GTEx DepMap Descartes 0.09 26.83
SLC1A2 -0.0002752 10409 GTEx DepMap Descartes 0.15 20.91
LDLR -0.0003299 10966 GTEx DepMap Descartes 0.05 11.50
HMGCR -0.0003369 11020 GTEx DepMap Descartes 0.09 34.44


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 7840.46
Median rank of genes in gene set: 10344
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ANKFN1 0.0043625 65 GTEx DepMap Descartes 1.30 618.93
PLXNA4 0.0036461 95 GTEx DepMap Descartes 0.90 132.86
SLC44A5 0.0024493 188 GTEx DepMap Descartes 1.02 495.14
NTRK1 0.0023553 201 GTEx DepMap Descartes 0.45 266.60
CNKSR2 0.0015397 415 GTEx DepMap Descartes 0.78 187.06
TMEFF2 0.0015149 426 GTEx DepMap Descartes 0.41 279.67
EYA1 0.0006273 1290 GTEx DepMap Descartes 0.97 431.13
FAT3 0.0005279 1531 GTEx DepMap Descartes 0.35 30.17
GAP43 0.0004713 1716 GTEx DepMap Descartes 0.76 712.89
PTCHD1 0.0004257 1883 GTEx DepMap Descartes 0.23 33.94
TMEM132C 0.0004237 1894 GTEx DepMap Descartes 2.20 838.87
CNTFR 0.0003689 2120 GTEx DepMap Descartes 0.20 178.49
REEP1 0.0002260 2924 GTEx DepMap Descartes 0.26 120.57
RPH3A 0.0000456 4820 GTEx DepMap Descartes 0.02 8.42
IL7 -0.0000818 7047 GTEx DepMap Descartes 0.99 1027.65
RGMB -0.0000881 7169 GTEx DepMap Descartes 0.25 94.03
GREM1 -0.0000927 7248 GTEx DepMap Descartes 0.01 2.20
EYA4 -0.0001126 7700 GTEx DepMap Descartes 0.73 268.72
CCND1 -0.0001303 8055 GTEx DepMap Descartes 1.25 516.27
MAB21L1 -0.0002533 10143 GTEx DepMap Descartes 0.11 56.13
BASP1 -0.0002693 10344 GTEx DepMap Descartes 0.52 486.77
RBFOX1 -0.0002883 10544 GTEx DepMap Descartes 3.49 1199.43
KCNB2 -0.0003183 10860 GTEx DepMap Descartes 0.66 314.64
SLC6A2 -0.0003806 11372 GTEx DepMap Descartes 0.13 65.49
SYNPO2 -0.0005391 12007 GTEx DepMap Descartes 0.25 24.58
MAB21L2 -0.0007266 12315 GTEx DepMap Descartes 0.02 10.27
RYR2 -0.0007920 12363 GTEx DepMap Descartes 2.13 212.40
EPHA6 -0.0008785 12411 GTEx DepMap Descartes 0.23 96.58
ELAVL2 -0.0009034 12422 GTEx DepMap Descartes 0.59 230.68
TUBB2A -0.0009071 12424 GTEx DepMap Descartes 0.30 245.66


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8434.92
Median rank of genes in gene set: 9006.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CDH13 0.0029511 142 GTEx DepMap Descartes 0.64 166.78
EHD3 0.0005995 1358 GTEx DepMap Descartes 0.05 21.80
CYP26B1 0.0003169 2386 GTEx DepMap Descartes 0.03 4.63
CRHBP 0.0001230 3892 GTEx DepMap Descartes 0.00 2.37
RASIP1 0.0001022 4114 GTEx DepMap Descartes 0.03 25.19
KANK3 0.0000954 4198 GTEx DepMap Descartes 0.02 10.73
HYAL2 0.0000381 4930 GTEx DepMap Descartes 0.04 14.01
CALCRL 0.0000339 4996 GTEx DepMap Descartes 0.14 20.62
PLVAP 0.0000002 5499 GTEx DepMap Descartes 0.05 35.85
TMEM88 -0.0000566 6537 GTEx DepMap Descartes 0.06 116.71
TIE1 -0.0000602 6603 GTEx DepMap Descartes 0.02 5.17
MMRN2 -0.0000952 7294 GTEx DepMap Descartes 0.01 1.79
GALNT15 -0.0000992 7389 GTEx DepMap Descartes 0.01 NA
NPR1 -0.0001324 8101 GTEx DepMap Descartes 0.00 0.00
RAMP2 -0.0001336 8133 GTEx DepMap Descartes 0.06 96.36
CDH5 -0.0001412 8284 GTEx DepMap Descartes 0.03 4.93
F8 -0.0001451 8373 GTEx DepMap Descartes 0.00 0.12
CLDN5 -0.0001473 8428 GTEx DepMap Descartes 0.03 6.49
SLCO2A1 -0.0001726 8901 GTEx DepMap Descartes 0.02 2.20
IRX3 -0.0001857 9112 GTEx DepMap Descartes 0.00 0.00
NR5A2 -0.0001948 9268 GTEx DepMap Descartes 0.06 15.93
CEACAM1 -0.0002409 9980 GTEx DepMap Descartes 0.02 17.49
FLT4 -0.0002474 10055 GTEx DepMap Descartes 0.01 2.81
TEK -0.0002529 10139 GTEx DepMap Descartes 0.03 5.46
PODXL -0.0002961 10642 GTEx DepMap Descartes 0.08 20.40
MYRIP -0.0003110 10784 GTEx DepMap Descartes 0.08 22.05
SHE -0.0003171 10839 GTEx DepMap Descartes 0.02 5.02
SHANK3 -0.0003788 11356 GTEx DepMap Descartes 0.06 8.87
ROBO4 -0.0003802 11369 GTEx DepMap Descartes 0.01 4.66
KDR -0.0003848 11398 GTEx DepMap Descartes 0.01 0.34


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.91e-01
Mean rank of genes in gene set: 6546.75
Median rank of genes in gene set: 7082.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PRICKLE1 0.0019651 292 GTEx DepMap Descartes 0.67 240.72
IGFBP3 0.0007493 1058 GTEx DepMap Descartes 0.20 51.13
COL6A3 0.0007060 1121 GTEx DepMap Descartes 0.23 41.50
DKK2 0.0005622 1444 GTEx DepMap Descartes 0.04 22.77
EDNRA 0.0004672 1728 GTEx DepMap Descartes 0.08 29.48
ADAMTS2 0.0004070 1965 GTEx DepMap Descartes 0.16 36.27
COL3A1 0.0004028 1978 GTEx DepMap Descartes 0.55 197.24
ELN 0.0003535 2200 GTEx DepMap Descartes 0.15 60.10
ABCC9 0.0003452 2237 GTEx DepMap Descartes 0.09 14.36
CCDC80 0.0003422 2248 GTEx DepMap Descartes 0.07 11.78
COL1A2 0.0002710 2634 GTEx DepMap Descartes 0.84 243.19
PRRX1 0.0002639 2678 GTEx DepMap Descartes 0.05 16.38
PAMR1 0.0002555 2719 GTEx DepMap Descartes 0.07 41.58
POSTN 0.0002400 2828 GTEx DepMap Descartes 0.16 74.33
C7 0.0001315 3785 GTEx DepMap Descartes 0.03 5.53
DCN 0.0001243 3876 GTEx DepMap Descartes 0.05 15.63
ITGA11 0.0000368 4948 GTEx DepMap Descartes 0.04 6.74
CD248 0.0000345 4989 GTEx DepMap Descartes 0.02 13.10
LAMC3 0.0000226 5160 GTEx DepMap Descartes 0.00 0.84
COL27A1 0.0000059 5415 GTEx DepMap Descartes 0.05 15.06
LOX -0.0000549 6501 GTEx DepMap Descartes 0.02 6.23
SCARA5 -0.0000803 7013 GTEx DepMap Descartes 0.00 0.00
COL1A1 -0.0000871 7152 GTEx DepMap Descartes 0.65 163.90
GLI2 -0.0001013 7425 GTEx DepMap Descartes 0.03 8.51
SFRP2 -0.0001057 7523 GTEx DepMap Descartes 0.04 52.67
RSPO3 -0.0001116 7670 GTEx DepMap Descartes 0.00 NA
ADAMTSL3 -0.0001165 7779 GTEx DepMap Descartes 0.02 3.09
ISLR -0.0001483 8446 GTEx DepMap Descartes 0.01 1.44
ACTA2 -0.0001799 9010 GTEx DepMap Descartes 0.07 57.83
OGN -0.0001855 9101 GTEx DepMap Descartes 0.01 5.31


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.49e-01
Mean rank of genes in gene set: 6200.13
Median rank of genes in gene set: 5232.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ROBO1 0.0041205 74 GTEx DepMap Descartes 4.85 1277.19
MGAT4C 0.0033319 108 GTEx DepMap Descartes 0.93 77.31
GRID2 0.0027552 158 GTEx DepMap Descartes 1.00 355.15
NTNG1 0.0012849 539 GTEx DepMap Descartes 0.74 311.70
UNC80 0.0012748 542 GTEx DepMap Descartes 0.98 120.38
PCSK2 0.0010565 701 GTEx DepMap Descartes 0.33 147.51
ST18 0.0009347 822 GTEx DepMap Descartes 0.14 46.53
TENM1 0.0009142 849 GTEx DepMap Descartes 0.54 NA
DGKK 0.0009090 853 GTEx DepMap Descartes 0.04 13.90
SLC18A1 0.0008917 872 GTEx DepMap Descartes 0.23 157.78
FAM155A 0.0007808 1008 GTEx DepMap Descartes 5.27 1042.38
TIAM1 0.0006491 1234 GTEx DepMap Descartes 0.70 200.19
LAMA3 0.0006266 1292 GTEx DepMap Descartes 0.12 19.15
SLC24A2 0.0005783 1405 GTEx DepMap Descartes 0.09 15.55
CHGB 0.0005687 1427 GTEx DepMap Descartes 1.03 797.23
GCH1 0.0005255 1535 GTEx DepMap Descartes 0.39 246.38
AGBL4 0.0004242 1890 GTEx DepMap Descartes 1.48 589.76
CNTN3 0.0002135 3030 GTEx DepMap Descartes 0.07 26.75
HTATSF1 0.0000275 5100 GTEx DepMap Descartes 0.09 58.51
SPOCK3 0.0000086 5365 GTEx DepMap Descartes 0.22 148.14
TBX20 -0.0000203 5827 GTEx DepMap Descartes 0.12 120.73
PENK -0.0001229 7903 GTEx DepMap Descartes 0.00 3.33
SORCS3 -0.0002274 9787 GTEx DepMap Descartes 0.01 1.74
C1QL1 -0.0003618 11223 GTEx DepMap Descartes 0.01 5.41
KCTD16 -0.0004691 11788 GTEx DepMap Descartes 0.69 72.03
GRM7 -0.0004949 11866 GTEx DepMap Descartes 0.07 26.87
PACRG -0.0005165 11934 GTEx DepMap Descartes 0.20 219.54
ARC -0.0005395 12008 GTEx DepMap Descartes 0.02 8.97
SLC35F3 -0.0006673 12244 GTEx DepMap Descartes 0.06 19.10
CHGA -0.0007719 12350 GTEx DepMap Descartes 0.56 280.95


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.03e-02
Mean rank of genes in gene set: 5171.38
Median rank of genes in gene set: 4045
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BLVRB 0.0030002 136 GTEx DepMap Descartes 0.10 146.71
SPECC1 0.0011398 638 GTEx DepMap Descartes 0.07 16.43
DENND4A 0.0008069 965 GTEx DepMap Descartes 0.64 123.34
SNCA 0.0005707 1423 GTEx DepMap Descartes 0.14 72.06
GYPC 0.0005409 1504 GTEx DepMap Descartes 0.01 7.52
MICAL2 0.0004927 1642 GTEx DepMap Descartes 0.08 28.75
EPB41 0.0004205 1909 GTEx DepMap Descartes 0.44 130.68
SLC25A21 0.0002772 2594 GTEx DepMap Descartes 0.02 17.37
SLC25A37 0.0002755 2605 GTEx DepMap Descartes 0.10 49.44
TRAK2 0.0002143 3021 GTEx DepMap Descartes 0.10 26.46
XPO7 0.0002138 3029 GTEx DepMap Descartes 0.20 73.17
SPTB 0.0001814 3303 GTEx DepMap Descartes 0.08 11.28
MARCH3 0.0001621 3480 GTEx DepMap Descartes 0.16 NA
CAT 0.0001119 4003 GTEx DepMap Descartes 0.05 39.81
CPOX 0.0001081 4045 GTEx DepMap Descartes 0.03 24.93
ABCB10 0.0000388 4918 GTEx DepMap Descartes 0.09 41.83
RGS6 0.0000081 5373 GTEx DepMap Descartes 0.01 2.74
TMCC2 0.0000039 5444 GTEx DepMap Descartes 0.04 14.32
SELENBP1 -0.0000292 5982 GTEx DepMap Descartes 0.00 4.14
ANK1 -0.0000428 6247 GTEx DepMap Descartes 0.16 34.44
RAPGEF2 -0.0000607 6613 GTEx DepMap Descartes 0.40 72.44
ALAS2 -0.0000995 7395 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0001276 8010 GTEx DepMap Descartes 0.00 0.00
GCLC -0.0001475 8431 GTEx DepMap Descartes 0.08 50.77
FECH -0.0002914 10587 GTEx DepMap Descartes 0.03 5.43
TSPAN5 -0.0002924 10601 GTEx DepMap Descartes 0.46 193.80
RHD -0.0003642 11245 GTEx DepMap Descartes 0.01 2.31
TFR2 -0.0007900 12359 GTEx DepMap Descartes 0.09 34.49
SOX6 -0.0010422 12468 GTEx DepMap Descartes 0.34 49.81
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.00e-15
Mean rank of genes in gene set: 1758.76
Median rank of genes in gene set: 344
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SPP1 0.0298595 1 GTEx DepMap Descartes 11.14 16904.96
CTSD 0.0133510 5 GTEx DepMap Descartes 1.66 2008.08
CTSB 0.0097785 8 GTEx DepMap Descartes 1.21 829.79
CD14 0.0064117 28 GTEx DepMap Descartes 0.23 346.68
TGFBI 0.0061742 32 GTEx DepMap Descartes 0.32 164.77
ABCA1 0.0047091 57 GTEx DepMap Descartes 0.46 98.15
LGMN 0.0039473 80 GTEx DepMap Descartes 0.42 475.11
HRH1 0.0036414 96 GTEx DepMap Descartes 0.25 126.32
FMN1 0.0033496 107 GTEx DepMap Descartes 2.15 313.62
SFMBT2 0.0031337 115 GTEx DepMap Descartes 0.69 158.28
MSR1 0.0030759 124 GTEx DepMap Descartes 0.22 163.99
SLC1A3 0.0026384 167 GTEx DepMap Descartes 0.15 91.50
ATP8B4 0.0024488 189 GTEx DepMap Descartes 0.10 41.00
MERTK 0.0022964 210 GTEx DepMap Descartes 0.13 73.34
MS4A4A 0.0022004 234 GTEx DepMap Descartes 0.04 55.21
CD163 0.0020899 259 GTEx DepMap Descartes 0.06 33.40
CTSS 0.0019710 291 GTEx DepMap Descartes 0.11 57.30
CST3 0.0018489 321 GTEx DepMap Descartes 0.31 192.93
RBPJ 0.0018444 325 GTEx DepMap Descartes 0.68 309.73
CSF1R 0.0017096 363 GTEx DepMap Descartes 0.08 42.15
PTPRE 0.0013545 504 GTEx DepMap Descartes 0.23 76.40
CD74 0.0012356 562 GTEx DepMap Descartes 0.48 320.12
SLCO2B1 0.0011583 622 GTEx DepMap Descartes 0.13 55.78
FGL2 0.0010673 689 GTEx DepMap Descartes 0.03 12.90
FGD2 0.0010120 741 GTEx DepMap Descartes 0.07 23.82
ADAP2 0.0008760 890 GTEx DepMap Descartes 0.16 111.47
CPVL 0.0008467 928 GTEx DepMap Descartes 0.09 156.20
CTSC 0.0007160 1109 GTEx DepMap Descartes 0.10 33.82
CYBB 0.0007067 1119 GTEx DepMap Descartes 0.07 25.85
ITPR2 0.0005740 1413 GTEx DepMap Descartes 0.29 49.44


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.78e-02
Mean rank of genes in gene set: 5500.82
Median rank of genes in gene set: 5393.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TRPM3 0.0070133 25 GTEx DepMap Descartes 0.95 166.63
VIM 0.0034057 106 GTEx DepMap Descartes 0.66 521.78
LRRTM4 0.0024769 182 GTEx DepMap Descartes 2.39 1322.71
GAS7 0.0020198 274 GTEx DepMap Descartes 0.22 65.49
NRXN3 0.0016294 388 GTEx DepMap Descartes 0.49 117.97
SCN7A 0.0015865 401 GTEx DepMap Descartes 0.34 91.44
FIGN 0.0015837 402 GTEx DepMap Descartes 0.40 87.74
PPP2R2B 0.0014896 438 GTEx DepMap Descartes 0.88 157.74
STARD13 0.0013958 480 GTEx DepMap Descartes 0.23 91.87
PMP22 0.0012151 576 GTEx DepMap Descartes 0.50 560.84
DST 0.0010478 710 GTEx DepMap Descartes 2.05 179.21
COL18A1 0.0010007 754 GTEx DepMap Descartes 0.43 99.95
VCAN 0.0007997 978 GTEx DepMap Descartes 0.29 54.23
SFRP1 0.0006363 1267 GTEx DepMap Descartes 0.15 84.96
NRXN1 0.0005434 1489 GTEx DepMap Descartes 1.50 321.37
GRIK3 0.0005109 1580 GTEx DepMap Descartes 0.05 8.97
KCTD12 0.0003502 2210 GTEx DepMap Descartes 0.05 14.46
PTN 0.0002330 2875 GTEx DepMap Descartes 0.19 199.04
PTPRZ1 0.0002191 2992 GTEx DepMap Descartes 0.00 2.73
SLC35F1 0.0001793 3320 GTEx DepMap Descartes 0.04 16.99
LAMC1 0.0000648 4552 GTEx DepMap Descartes 0.16 40.14
OLFML2A 0.0000115 5309 GTEx DepMap Descartes 0.01 1.01
MDGA2 0.0000023 5478 GTEx DepMap Descartes 0.00 0.00
LAMA4 -0.0000103 5667 GTEx DepMap Descartes 0.08 18.39
XKR4 -0.0000187 5794 GTEx DepMap Descartes 0.18 14.92
MPZ -0.0000244 5896 GTEx DepMap Descartes 0.00 0.48
IL1RAPL2 -0.0000277 5953 GTEx DepMap Descartes 0.04 21.39
HMGA2 -0.0000791 6980 GTEx DepMap Descartes 0.01 3.27
PLP1 -0.0001275 8007 GTEx DepMap Descartes 0.00 0.00
ERBB3 -0.0001355 8171 GTEx DepMap Descartes 0.01 4.29


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.57e-06
Mean rank of genes in gene set: 3925.76
Median rank of genes in gene set: 2369
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC2A3 0.0092391 11 GTEx DepMap Descartes 0.64 323.63
GSN 0.0049645 52 GTEx DepMap Descartes 0.33 112.83
CD9 0.0028476 148 GTEx DepMap Descartes 0.28 364.10
LIMS1 0.0026864 164 GTEx DepMap Descartes 0.44 215.66
PLEK 0.0021910 236 GTEx DepMap Descartes 0.07 54.40
CD84 0.0020188 275 GTEx DepMap Descartes 0.07 17.93
PDE3A 0.0018899 309 GTEx DepMap Descartes 1.09 277.90
FERMT3 0.0017909 341 GTEx DepMap Descartes 0.05 51.74
ACTB 0.0017595 348 GTEx DepMap Descartes 3.15 2544.66
UBASH3B 0.0017183 359 GTEx DepMap Descartes 0.15 43.48
FLNA 0.0010414 717 GTEx DepMap Descartes 0.32 70.17
MYH9 0.0009450 812 GTEx DepMap Descartes 0.31 62.60
TUBB1 0.0009260 833 GTEx DepMap Descartes 0.01 5.68
RAP1B 0.0007863 1004 GTEx DepMap Descartes 0.25 35.93
ZYX 0.0006346 1273 GTEx DepMap Descartes 0.10 111.64
TPM4 0.0006122 1323 GTEx DepMap Descartes 0.21 93.94
ACTN1 0.0005739 1415 GTEx DepMap Descartes 0.33 136.97
SPN 0.0005662 1433 GTEx DepMap Descartes 0.02 3.77
TMSB4X 0.0005611 1447 GTEx DepMap Descartes 3.49 2955.18
FLI1 0.0005206 1552 GTEx DepMap Descartes 0.16 52.34
MCTP1 0.0004019 1986 GTEx DepMap Descartes 0.39 86.15
INPP4B 0.0003804 2070 GTEx DepMap Descartes 0.59 130.07
TGFB1 0.0003204 2369 GTEx DepMap Descartes 0.11 77.81
TLN1 0.0003138 2402 GTEx DepMap Descartes 0.09 16.03
P2RX1 0.0002655 2667 GTEx DepMap Descartes 0.01 9.14
STON2 0.0002538 2733 GTEx DepMap Descartes 0.07 36.92
STOM 0.0002379 2839 GTEx DepMap Descartes 0.08 47.84
PSTPIP2 0.0001492 3599 GTEx DepMap Descartes 0.02 15.18
THBS1 0.0001466 3631 GTEx DepMap Descartes 0.19 63.22
ARHGAP6 0.0001258 3850 GTEx DepMap Descartes 0.06 17.31


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-05
Mean rank of genes in gene set: 4187.36
Median rank of genes in gene set: 1728.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0051099 49 GTEx DepMap Descartes 2.15 1602.43
ITPKB 0.0035924 98 GTEx DepMap Descartes 0.16 66.72
CELF2 0.0035526 100 GTEx DepMap Descartes 0.70 188.22
MSN 0.0022112 232 GTEx DepMap Descartes 0.16 74.05
ARID5B 0.0021522 242 GTEx DepMap Descartes 0.30 83.20
LCP1 0.0018934 306 GTEx DepMap Descartes 0.10 61.02
CD44 0.0017946 338 GTEx DepMap Descartes 0.71 274.79
PTPRC 0.0017466 350 GTEx DepMap Descartes 0.19 99.90
STK39 0.0017006 366 GTEx DepMap Descartes 0.89 519.27
PLEKHA2 0.0015445 413 GTEx DepMap Descartes 0.14 58.64
ARHGDIB 0.0011735 615 GTEx DepMap Descartes 0.05 67.39
RAP1GAP2 0.0008721 898 GTEx DepMap Descartes 1.09 287.30
PRKCH 0.0008604 912 GTEx DepMap Descartes 0.20 97.75
GNG2 0.0008202 949 GTEx DepMap Descartes 0.50 265.83
FOXP1 0.0007875 1001 GTEx DepMap Descartes 1.45 288.35
SP100 0.0007125 1114 GTEx DepMap Descartes 0.12 46.33
ARHGAP15 0.0005876 1387 GTEx DepMap Descartes 0.28 185.54
MBNL1 0.0005242 1540 GTEx DepMap Descartes 0.50 152.36
RCSD1 0.0005013 1612 GTEx DepMap Descartes 0.06 22.93
DOCK10 0.0004965 1631 GTEx DepMap Descartes 0.43 131.16
ANKRD44 0.0004951 1634 GTEx DepMap Descartes 0.36 100.58
IKZF1 0.0004392 1823 GTEx DepMap Descartes 0.06 27.67
SORL1 0.0003959 2011 GTEx DepMap Descartes 0.23 41.55
WIPF1 0.0003886 2040 GTEx DepMap Descartes 0.24 99.99
PITPNC1 0.0003084 2423 GTEx DepMap Descartes 0.71 193.05
SCML4 0.0002355 2859 GTEx DepMap Descartes 0.20 74.44
NCALD 0.0001822 3291 GTEx DepMap Descartes 0.25 115.10
TOX 0.0000686 4508 GTEx DepMap Descartes 1.01 426.72
EVL 0.0000181 5207 GTEx DepMap Descartes 0.85 422.96
SAMD3 0.0000112 5316 GTEx DepMap Descartes 0.05 19.33


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.05e-05
Mean rank of genes in gene set: 162.4
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TYROBP 0.0076193 22 GTEx DepMap Descartes 0.28 1005.51
SRGN 0.0059010 40 GTEx DepMap Descartes 0.49 949.73
S100A6 0.0030428 129 GTEx DepMap Descartes 0.54 1164.19
FTH1 0.0020207 273 GTEx DepMap Descartes 1.44 2191.85
ACTB 0.0017595 348 GTEx DepMap Descartes 3.15 2544.66


T cells: Treg(diff) (model markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.78e-04
Mean rank of genes in gene set: 472.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RGS1 0.0062721 29 GTEx DepMap Descartes 0.28 263.52
S100A4 0.0058178 42 GTEx DepMap Descartes 0.22 700.92
PTPRC 0.0017466 350 GTEx DepMap Descartes 0.19 99.90
TSC22D3 0.0005528 1469 GTEx DepMap Descartes 0.11 70.11


Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.45e-03
Mean rank of genes in gene set: 47
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NEAT1 0.0092469 10 GTEx DepMap Descartes 6.58 596.42
TYROBP 0.0076193 22 GTEx DepMap Descartes 0.28 1005.51
SAT1 0.0032969 109 GTEx DepMap Descartes 1.33 2541.27