Program: 22. Neuroblastoma: MYCN.

Program: 22. Neuroblastoma: MYCN.



Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 NPM1 0.0089061 nucleophosmin 1 GTEx DepMap Descartes 72.58 10154.90
2 ZFHX4 0.0084619 zinc finger homeobox 4 GTEx DepMap Descartes 8.61 152.50
3 EEF1B2 0.0079631 eukaryotic translation elongation factor 1 beta 2 GTEx DepMap Descartes 68.66 14866.95
4 EEF2 0.0077246 eukaryotic translation elongation factor 2 GTEx DepMap Descartes 62.59 4741.15
5 PEX2 0.0075055 peroxisomal biogenesis factor 2 GTEx DepMap Descartes 8.60 487.15
6 NACA 0.0074465 nascent polypeptide associated complex subunit alpha GTEx DepMap Descartes 72.58 2600.56
7 NPW 0.0074434 neuropeptide W GTEx DepMap Descartes 3.99 1265.90
8 PKIA 0.0071768 cAMP-dependent protein kinase inhibitor alpha GTEx DepMap Descartes 8.91 506.47
9 IL7 0.0070711 interleukin 7 GTEx DepMap Descartes 8.03 947.57
10 EEF1A1 0.0070185 eukaryotic translation elongation factor 1 alpha 1 GTEx DepMap Descartes 320.13 17070.53
11 HNRNPA1 0.0068706 heterogeneous nuclear ribonucleoprotein A1 GTEx DepMap Descartes 67.17 3955.34
12 UQCRH 0.0067470 ubiquinol-cytochrome c reductase hinge protein GTEx DepMap Descartes 27.91 9104.95
13 POLR1D 0.0066464 RNA polymerase I and III subunit D GTEx DepMap Descartes 12.40 636.56
14 BTF3 0.0066455 basic transcription factor 3 GTEx DepMap Descartes 51.24 9920.10
15 TIPIN 0.0066091 TIMELESS interacting protein GTEx DepMap Descartes 14.03 1950.25
16 ICA1 0.0064615 islet cell autoantigen 1 GTEx DepMap Descartes 7.34 795.28
17 EIF3L 0.0064030 eukaryotic translation initiation factor 3 subunit L GTEx DepMap Descartes 23.64 1722.74
18 ACTN2 0.0063845 actinin alpha 2 GTEx DepMap Descartes 1.79 82.26
19 MEIS2 0.0063732 Meis homeobox 2 GTEx DepMap Descartes 7.19 370.74
20 CDK6 0.0062530 cyclin dependent kinase 6 GTEx DepMap Descartes 8.35 171.74
21 RPSA 0.0060520 ribosomal protein SA GTEx DepMap Descartes 74.56 8582.03
22 RPL18 0.0059225 ribosomal protein L18 GTEx DepMap Descartes 98.11 5910.89
23 ZC2HC1A 0.0058891 zinc finger C2HC-type containing 1A GTEx DepMap Descartes 7.22 NA
24 NBEAL1 0.0056813 neurobeachin like 1 GTEx DepMap Descartes 48.00 993.06
25 EIF4A2 0.0056213 eukaryotic translation initiation factor 4A2 GTEx DepMap Descartes 18.87 864.39
26 GAL 0.0054785 galanin and GMAP prepropeptide GTEx DepMap Descartes 17.53 5514.95
27 EPCAM 0.0053776 epithelial cell adhesion molecule GTEx DepMap Descartes 1.64 241.26
28 IFI27 0.0053356 interferon alpha inducible protein 27 GTEx DepMap Descartes 19.27 1979.87
29 ARL9 0.0053330 ADP ribosylation factor like GTPase 9 GTEx DepMap Descartes 0.57 90.09
30 MYC 0.0052663 MYC proto-oncogene, bHLH transcription factor GTEx DepMap Descartes 9.01 600.21
31 MYL6B 0.0051744 myosin light chain 6B GTEx DepMap Descartes 6.67 1180.64
32 GLCCI1 0.0050009 glucocorticoid induced 1 GTEx DepMap Descartes 5.04 261.82
33 CCNI 0.0049622 cyclin I GTEx DepMap Descartes 22.13 1804.42
34 PHB2 0.0049616 prohibitin 2 GTEx DepMap Descartes 6.97 1099.10
35 PPP1R14B 0.0049223 protein phosphatase 1 regulatory inhibitor subunit 14B GTEx DepMap Descartes 7.15 1441.12
36 PHOX2A 0.0048503 paired like homeobox 2A GTEx DepMap Descartes 7.94 1160.99
37 TTC3 0.0048378 tetratricopeptide repeat domain 3 GTEx DepMap Descartes 12.11 NA
38 EBPL 0.0048313 EBP like GTEx DepMap Descartes 4.48 1048.31
39 RPL13 0.0047588 ribosomal protein L13 GTEx DepMap Descartes 247.80 12732.50
40 YBX1 0.0046965 Y-box binding protein 1 GTEx DepMap Descartes 46.08 3316.69
41 EIF3E 0.0046828 eukaryotic translation initiation factor 3 subunit E GTEx DepMap Descartes 18.31 2123.68
42 NME2 0.0046404 NME/NM23 nucleoside diphosphate kinase 2 GTEx DepMap Descartes 5.13 1232.97
43 AHCY 0.0046103 adenosylhomocysteinase GTEx DepMap Descartes 3.78 344.92
44 DLL3 0.0046056 delta like canonical Notch ligand 3 GTEx DepMap Descartes 0.98 93.22
45 MDK 0.0045787 midkine GTEx DepMap Descartes 10.30 1971.22
46 MEG3 0.0045510 maternally expressed 3 GTEx DepMap Descartes 58.05 1267.76
47 KHDRBS1 0.0045028 KH RNA binding domain containing, signal transduction associated 1 GTEx DepMap Descartes 9.10 764.78
48 MUC4 0.0044736 mucin 4, cell surface associated GTEx DepMap Descartes 0.54 6.09
49 NSA2 0.0044644 NSA2 ribosome biogenesis factor GTEx DepMap Descartes 7.35 394.25
50 RSPO4 0.0044594 R-spondin 4 GTEx DepMap Descartes 0.51 43.51


Dowload full table

UMAP plots showing activity of gene expression program identified in GEP 22. Neuroblastoma: MYCN:

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 22. Neuroblastoma: MYCN:
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
RUBENSTEIN_SKELETAL_MUSCLE_SATELLITE_CELLS 4.16e-17 24.08 12.57 9.84e-15 2.79e-14
18NPM1, EEF1B2, EEF2, NACA, EEF1A1, HNRNPA1, UQCRH, BTF3, EIF3L, RPSA, RPL18, EIF4A2, MYC, PPP1R14B, TTC3, RPL13, EIF3E, MEG3
 310
BUSSLINGER_DUODENAL_STEM_CELLS 4.40e-17 24.00 12.53 9.84e-15 2.95e-14
18NPM1, EEF1B2, EEF2, EEF1A1, HNRNPA1, BTF3, EIF3L, CDK6, RPL18, EIF4A2, EPCAM, TTC3, RPL13, YBX1, EIF3E, AHCY, KHDRBS1, NSA2
 311
FAN_EMBRYONIC_CTX_EX_2_EXCITATORY_NEURON 3.20e-05 61.17 10.83 8.59e-04 2.15e-02
3ZFHX4, MEIS2, MDK
 16
TRAVAGLINI_LUNG_PROXIMAL_BASAL_CELL 8.88e-18 17.59 9.57 5.96e-15 5.96e-15
23NPM1, EEF1B2, EEF2, NACA, EEF1A1, HNRNPA1, UQCRH, POLR1D, BTF3, EIF3L, MEIS2, RPSA, RPL18, EIF4A2, MYL6B, CCNI, PHB2, EBPL, RPL13, YBX1, EIF3E, AHCY, MDK
 629
BUSSLINGER_DUODENAL_TRANSIT_AMPLIFYING_CELLS 1.71e-10 19.26 8.76 1.64e-08 1.15e-07
11NPM1, EEF1B2, EEF2, EEF1A1, HNRNPA1, EIF3L, RPL18, EPCAM, PHB2, RPL13, YBX1
 194
FAN_OVARY_CL0_XBP1_SELK_HIGH_STROMAL_CELL 3.84e-09 20.46 8.57 2.34e-07 2.58e-06
9NPM1, NACA, BTF3, RPL18, EIF4A2, RPL13, YBX1, EIF3E, MEG3
 143
BUSSLINGER_GASTRIC_PPP1R1B_POSITIVE_CELLS 2.10e-08 21.07 8.35 1.09e-06 1.41e-05
8NPM1, EEF1B2, EEF2, EEF1A1, HNRNPA1, RPL18, EPCAM, RPL13
 121
BUSSLINGER_DUODENAL_DIFFERENTIATING_STEM_CELLS 5.80e-12 16.71 8.23 7.78e-10 3.89e-09
14NPM1, EEF1B2, EEF2, EEF1A1, HNRNPA1, BTF3, EIF3L, RPL18, EPCAM, PHB2, RPL13, YBX1, EIF3E, AHCY
 305
RUBENSTEIN_SKELETAL_MUSCLE_T_CELLS 1.65e-09 18.27 8.01 1.23e-07 1.11e-06
10NPM1, EEF1B2, EEF1A1, HNRNPA1, BTF3, EIF3L, RPSA, RPL18, RPL13, EIF3E
 181
LAKE_ADULT_KIDNEY_C8_DECENDING_THIN_LIMB 3.05e-11 16.58 7.99 3.41e-09 2.05e-08
13NPM1, EEF1B2, EEF2, NACA, EEF1A1, BTF3, RPSA, RPL18, EIF4A2, EPCAM, CCNI, RPL13, YBX1
 278
LAKE_ADULT_KIDNEY_C9_THIN_ASCENDING_LIMB 3.27e-10 15.42 7.25 2.75e-08 2.20e-07
12NPM1, EEF2, NACA, EEF1A1, BTF3, RPSA, RPL18, EIF4A2, EPCAM, CCNI, RPL13, YBX1
 268
TRAVAGLINI_LUNG_BASAL_CELL 4.08e-08 15.33 6.45 1.96e-06 2.74e-05
9NPM1, NACA, EEF1A1, HNRNPA1, BTF3, RPSA, MYC, RPL13, AHCY
 188
BUSSLINGER_ESOPHAGEAL_PROLIFERATING_BASAL_CELLS 7.93e-06 21.34 6.41 2.53e-04 5.32e-03
5EEF1B2, EEF2, EEF1A1, HNRNPA1, YBX1
 70
LAKE_ADULT_KIDNEY_C18_COLLECTING_DUCT_PRINCIPAL_CELLS_MEDULLA 2.54e-09 12.74 6.00 1.70e-07 1.70e-06
12NPM1, EEF2, NACA, EEF1A1, BTF3, RPSA, RPL18, EIF4A2, EPCAM, CCNI, RPL13, YBX1
 322
LAKE_ADULT_KIDNEY_C7_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S3 9.03e-07 15.89 5.92 3.19e-05 6.06e-04
7NPM1, EEF2, EEF1A1, RPSA, RPL18, CCNI, RPL13
 135
TRAVAGLINI_LUNG_PROLIFERATING_BASAL_CELL 1.51e-12 10.42 5.62 2.53e-10 1.01e-09
21NPM1, EEF1B2, EEF2, NACA, EEF1A1, HNRNPA1, UQCRH, POLR1D, BTF3, EIF3L, RPSA, RPL18, MYL6B, PHB2, PPP1R14B, RPL13, YBX1, EIF3E, AHCY, MDK, KHDRBS1
 891
TRAVAGLINI_LUNG_BRONCHIAL_VESSEL_1_CELL 1.79e-07 12.77 5.39 8.02e-06 1.20e-04
9NPM1, EEF2, NACA, HNRNPA1, RPSA, RPL18, MYC, RPL13, EIF3E
 224
FAN_OVARY_CL1_GPRC5A_TNFRS12A_HIGH_SELECTABLE_FOLLICLE_STROMAL_CELL 1.55e-08 10.73 5.06 8.66e-07 1.04e-05
12NPM1, EEF2, NACA, EEF1A1, HNRNPA1, RPSA, RPL18, MYC, CCNI, YBX1, EIF3E, MEG3
 380
MENON_FETAL_KIDNEY_1_EMBRYONIC_RED_BLOOD_CELLS 9.51e-06 14.20 4.85 2.90e-04 6.38e-03
6NPM1, EEF1B2, NACA, BTF3, RPSA, YBX1
 126
HAY_BONE_MARROW_EARLY_ERYTHROBLAST 3.49e-05 15.42 4.67 9.01e-04 2.34e-02
5NPM1, UQCRH, GAL, MYC, AHCY
 95

Dowload full table

mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_MYC_TARGETS_V1 1.24e-04 8.78 3.02 6.18e-03 6.18e-03
6NPM1, EEF1B2, HNRNPA1, RPL18, MYC, PHB2
 200
HALLMARK_MYOGENESIS 7.71e-03 5.55 1.44 1.67e-01 3.85e-01
4PKIA, ACTN2, EIF4A2, MYL6B
 200
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 1.00e-02 7.25 1.42 1.67e-01 5.00e-01
3NPM1, EEF2, EIF4A2
 113
HALLMARK_MYC_TARGETS_V2 2.21e-02 9.30 1.07 2.77e-01 1.00e+00
2NPM1, MYC
 58
HALLMARK_INTERFERON_ALPHA_RESPONSE 5.62e-02 5.48 0.64 5.44e-01 1.00e+00
2IL7, IFI27
 97
HALLMARK_UV_RESPONSE_DN 1.10e-01 3.67 0.43 5.44e-01 1.00e+00
2ICA1, MYC
 144
HALLMARK_UV_RESPONSE_UP 1.28e-01 3.34 0.39 5.44e-01 1.00e+00
2GAL, EPCAM
 158
HALLMARK_IL2_STAT5_SIGNALING 1.83e-01 2.64 0.31 5.44e-01 1.00e+00
2MYC, AHCY
 199
HALLMARK_G2M_CHECKPOINT 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2MEIS2, MYC
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2GAL, MDK
 200
HALLMARK_INTERFERON_GAMMA_RESPONSE 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2IL7, IFI27
 200
HALLMARK_APICAL_JUNCTION 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2ACTN2, MDK
 200
HALLMARK_E2F_TARGETS 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2TIPIN, MYC
 200
HALLMARK_OXIDATIVE_PHOSPHORYLATION 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2UQCRH, PHB2
 200
HALLMARK_ALLOGRAFT_REJECTION 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2NPM1, IL7
 200
HALLMARK_HEDGEHOG_SIGNALING 1.34e-01 7.29 0.18 5.44e-01 1.00e+00
1CDK6
 36
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.54e-01 6.22 0.15 5.44e-01 1.00e+00
1MYC
 42
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 8.06e-01 1.00e+00
1IL7
 87
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 8.06e-01 1.00e+00
1ICA1
 96
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 8.06e-01 1.00e+00
1CDK6
 100

Dowload full table

KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_RIBOSOME 5.05e-03 9.38 1.83 9.39e-01 9.39e-01
3RPSA, RPL18, RPL13
 88
KEGG_CHRONIC_MYELOID_LEUKEMIA 3.38e-02 7.33 0.85 1.00e+00 1.00e+00
2CDK6, MYC
 73
KEGG_SMALL_CELL_LUNG_CANCER 4.36e-02 6.35 0.74 1.00e+00 1.00e+00
2CDK6, MYC
 84
KEGG_PYRIMIDINE_METABOLISM 5.73e-02 5.42 0.63 1.00e+00 1.00e+00
2POLR1D, NME2
 98
KEGG_CELL_CYCLE 8.71e-02 4.23 0.49 1.00e+00 1.00e+00
2CDK6, MYC
 125
KEGG_JAK_STAT_SIGNALING_PATHWAY 1.24e-01 3.40 0.40 1.00e+00 1.00e+00
2IL7, MYC
 155
KEGG_PURINE_METABOLISM 1.29e-01 3.32 0.39 1.00e+00 1.00e+00
2POLR1D, NME2
 159
KEGG_SELENOAMINO_ACID_METABOLISM 9.85e-02 10.19 0.24 1.00e+00 1.00e+00
1AHCY
 26
KEGG_RNA_POLYMERASE 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1POLR1D
 29
KEGG_THYROID_CANCER 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1MYC
 29
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2CDK6, MYC
 325
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 1.27e-01 7.73 0.19 1.00e+00 1.00e+00
1AHCY
 34
KEGG_BLADDER_CANCER 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1MYC
 42
KEGG_TYPE_I_DIABETES_MELLITUS 1.57e-01 6.07 0.15 1.00e+00 1.00e+00
1ICA1
 43
KEGG_NOTCH_SIGNALING_PATHWAY 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1DLL3
 47
KEGG_ENDOMETRIAL_CANCER 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1MYC
 52
KEGG_NON_SMALL_CELL_LUNG_CANCER 1.94e-01 4.81 0.12 1.00e+00 1.00e+00
1CDK6
 54
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1POLR1D
 55
KEGG_ACUTE_MYELOID_LEUKEMIA 2.03e-01 4.55 0.11 1.00e+00 1.00e+00
1MYC
 57
KEGG_COLORECTAL_CANCER 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1MYC
 62

Dowload full table

CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr8q21 6.44e-04 8.03 2.46 1.79e-01 1.79e-01
5ZFHX4, PEX2, PKIA, IL7, ZC2HC1A
 178
chr7p21 4.26e-02 6.43 0.74 1.00e+00 1.00e+00
2ICA1, GLCCI1
 83
chr5q13 1.08e-01 3.72 0.43 1.00e+00 1.00e+00
2BTF3, NSA2
 142
chr12q13 2.07e-01 1.98 0.39 1.00e+00 1.00e+00
3NACA, HNRNPA1, MYL6B
 407
chr11q13 2.21e-01 1.91 0.38 1.00e+00 1.00e+00
3GAL, PPP1R14B, PHOX2A
 421
chr2q33 1.78e-01 2.70 0.32 1.00e+00 1.00e+00
2EEF1B2, NBEAL1
 195
chr8q23 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1EIF3E
 44
chr15q14 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1MEIS2
 56
chr6q13 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1EEF1A1
 56
chr14q32 1.00e+00 0.96 0.11 1.00e+00 1.00e+00
2IFI27, MEG3
 546
chr1p33 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1UQCRH
 60
chr1q43 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1ACTN2
 60
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1ARL9
 79
chr2p21 2.73e-01 3.23 0.08 1.00e+00 1.00e+00
1EPCAM
 80
chr3q27 3.67e-01 2.24 0.06 1.00e+00 1.00e+00
1EIF4A2
 115
chr20p13 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1RSPO4
 117
chr19q13 4.39e-01 0.45 0.05 1.00e+00 1.00e+00
2RPL18, DLL3
 1165
chr3q29 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1MUC4
 122
chr15q22 3.89e-01 2.07 0.05 1.00e+00 1.00e+00
1TIPIN
 124
chr1p35 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1KHDRBS1
 130

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GTF2A2_TARGET_GENES 2.30e-05 6.11 2.71 2.61e-02 2.61e-02
10NPM1, EEF2, EEF1A1, HNRNPA1, RPSA, RPL18, EIF4A2, MYC, CCNI, RPL13
 522
PSMB5_TARGET_GENES 1.16e-03 5.66 1.96 3.99e-01 1.00e+00
6NPM1, EEF2, EEF1A1, RPSA, EIF4A2, PPP1R14B
 307
PER1_TARGET_GENES 7.55e-03 16.78 1.89 7.81e-01 1.00e+00
2EEF1A1, EIF4A2
 33
GCCATNTTG_YY1_Q6 1.33e-03 4.73 1.79 3.99e-01 1.00e+00
7EEF1B2, NACA, HNRNPA1, UQCRH, BTF3, PHB2, YBX1
 437
YY1_Q6 2.88e-03 5.65 1.73 6.51e-01 1.00e+00
5NACA, EEF1A1, UQCRH, BTF3, YBX1
 251
FOXE1_TARGET_GENES 1.41e-03 3.82 1.63 3.99e-01 1.00e+00
9EEF2, NACA, PKIA, HNRNPA1, UQCRH, RPL18, EIF4A2, RPL13, YBX1
 728
RUVBL1_TARGET_GENES 5.37e-03 6.17 1.60 7.26e-01 1.00e+00
4NACA, EEF1A1, RPL18, PHB2
 180
ADA2_TARGET_GENES 3.69e-03 3.28 1.40 6.97e-01 1.00e+00
9ZFHX4, EEF2, EEF1A1, MEIS2, RPL18, EIF4A2, PHB2, RPL13, NSA2
 846
ATF5_TARGET_GENES 7.89e-03 3.77 1.31 7.81e-01 1.00e+00
6UQCRH, BTF3, MEIS2, EIF4A2, EPCAM, NSA2
 458
KAT5_TARGET_GENES 5.77e-03 3.05 1.30 7.26e-01 1.00e+00
9EEF1B2, NACA, NPW, EEF1A1, UQCRH, CDK6, RPSA, RPL13, EIF3E
 910
PHF2_TARGET_GENES 5.02e-03 2.68 1.27 7.26e-01 1.00e+00
12NACA, HNRNPA1, POLR1D, EIF3L, MEIS2, EIF4A2, CCNI, PPP1R14B, RPL13, AHCY, KHDRBS1, NSA2
 1485
EMX1_TARGET_GENES 1.16e-02 4.90 1.27 8.35e-01 1.00e+00
4NPM1, UQCRH, EIF4A2, CCNI
 226
PBX1_02 1.51e-02 6.18 1.22 8.35e-01 1.00e+00
3IL7, MEIS2, KHDRBS1
 132
E2F_Q3_01 1.34e-02 4.69 1.21 8.35e-01 1.00e+00
4HNRNPA1, TIPIN, MEIS2, MYC
 236
E2F_Q4_01 1.38e-02 4.65 1.20 8.35e-01 1.00e+00
4HNRNPA1, TIPIN, MEIS2, MYC
 238
PR_02 1.61e-02 6.04 1.19 8.35e-01 1.00e+00
3ZFHX4, EEF1B2, KHDRBS1
 135
E2F1_Q6_01 1.48e-02 4.55 1.18 8.35e-01 1.00e+00
4HNRNPA1, MEIS2, RPL18, MYC
 243
SMAD4_Q6 1.50e-02 4.53 1.17 8.35e-01 1.00e+00
4EEF1A1, MEIS2, CDK6, MYL6B
 244
SNRNP70_TARGET_GENES 1.06e-02 2.75 1.17 8.35e-01 1.00e+00
9EEF2, NACA, EEF1A1, HNRNPA1, RPL18, EIF4A2, RPL13, NME2, AHCY
 1009
NFMUE1_Q6 1.62e-02 4.42 1.15 8.35e-01 1.00e+00
4NACA, EEF1A1, HNRNPA1, UQCRH
 250

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_NEGATIVE_REGULATION_OF_MONOCYTE_DIFFERENTIATION 4.28e-04 86.37 8.33 3.89e-01 1.00e+00
2CDK6, MYC
 8
GOBP_CYTOPLASMIC_TRANSLATION 2.82e-06 17.74 6.04 1.06e-02 2.11e-02
6EEF2, EIF3L, RPSA, RPL18, EIF4A2, EIF3E
 102
GOBP_TRANSLATIONAL_INITIATION 7.46e-07 12.87 5.15 5.58e-03 5.58e-03
8NPM1, EIF3L, RPSA, RPL18, EIF4A2, RPL13, EIF3E, KHDRBS1
 193
GOBP_CYTOPLASMIC_TRANSLATIONAL_INITIATION 3.24e-04 25.71 4.86 3.46e-01 1.00e+00
3EIF3L, EIF4A2, EIF3E
 34
GOBP_FORMATION_OF_CYTOPLASMIC_TRANSLATION_INITIATION_COMPLEX 1.80e-03 37.11 3.99 9.14e-01 1.00e+00
2EIF3L, EIF3E
 16
GOBP_REGULATION_OF_TRANSLATIONAL_INITIATION 2.76e-04 14.30 3.65 3.44e-01 1.00e+00
4NPM1, EIF4A2, EIF3E, KHDRBS1
 80
GOBP_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION 8.97e-04 17.71 3.40 5.60e-01 1.00e+00
3CDK6, MYC, NME2
 48
GOBP_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION 4.68e-04 12.34 3.16 3.89e-01 1.00e+00
4MEIS2, CDK6, MYC, NME2
 92
GOBP_REGULATION_OF_MONOCYTE_DIFFERENTIATION 3.10e-03 27.37 3.01 1.00e+00 1.00e+00
2CDK6, MYC
 21
GOBP_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE 3.40e-03 26.01 2.87 1.00e+00 1.00e+00
2CDK6, YBX1
 22
GOBP_NEGATIVE_REGULATION_OF_HEMOPOIESIS 7.69e-04 10.75 2.76 5.60e-01 1.00e+00
4CDK6, MYC, NME2, MDK
 105
GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS 1.39e-05 5.43 2.57 3.47e-02 1.04e-01
12NPM1, EEF1B2, EEF2, EEF1A1, EIF3L, RPSA, RPL18, EIF4A2, RPL13, YBX1, EIF3E, KHDRBS1
 740
GOBP_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 4.39e-03 22.60 2.52 1.00e+00 1.00e+00
2ACTN2, GAL
 25
GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 1.26e-03 9.37 2.41 7.25e-01 1.00e+00
4RPSA, RPL18, RPL13, EIF3E
 120
GOBP_NEGATIVE_REGULATION_OF_CELL_AGING 5.48e-03 20.00 2.24 1.00e+00 1.00e+00
2CDK6, YBX1
 28
GOBP_POSITIVE_REGULATION_OF_TRANSLATION 1.83e-03 8.43 2.17 9.14e-01 1.00e+00
4NPM1, EEF2, EIF3E, KHDRBS1
 133
GOBP_AMIDE_BIOSYNTHETIC_PROCESS 6.73e-05 4.57 2.16 1.26e-01 5.04e-01
12NPM1, EEF1B2, EEF2, EEF1A1, EIF3L, RPSA, RPL18, EIF4A2, RPL13, YBX1, EIF3E, KHDRBS1
 877
GOBP_PEPTIDE_METABOLIC_PROCESS 8.76e-05 4.43 2.10 1.31e-01 6.55e-01
12NPM1, EEF1B2, EEF2, EEF1A1, EIF3L, RPSA, RPL18, EIF4A2, RPL13, YBX1, EIF3E, KHDRBS1
 903
GOBP_FIBROBLAST_PROLIFERATION 3.87e-03 10.36 2.02 1.00e+00 1.00e+00
3PEX2, CDK6, MYC
 80
GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION 6.69e-03 17.94 2.02 1.00e+00 1.00e+00
2PEX2, MYC
 31

Dowload full table

Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_UP 9.73e-07 12.40 4.96 2.37e-03 4.74e-03
8EEF1B2, EEF2, NACA, UQCRH, BTF3, EIF3L, RPL18, RPL13
 200
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_2H_DN 9.73e-07 12.40 4.96 2.37e-03 4.74e-03
8EEF2, NACA, POLR1D, BTF3, EIF3L, RPL13, EIF3E, NSA2
 200
GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP 1.15e-05 10.60 3.97 8.26e-03 5.60e-02
7NPM1, EEF2, PKIA, HNRNPA1, EIF3L, EIF4A2, TTC3
 199
GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_DN 1.15e-05 10.60 3.97 8.26e-03 5.60e-02
7NPM1, PEX2, POLR1D, PHB2, YBX1, AHCY, DLL3
 199
GSE17301_CTRL_VS_48H_ACD3_ACD28_STIM_CD8_TCELL_UP 1.15e-05 10.60 3.97 8.26e-03 5.60e-02
7EEF2, HNRNPA1, RPL18, EIF4A2, MYC, PHB2, PPP1R14B
 199
GSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 1.19e-05 10.54 3.95 8.26e-03 5.79e-02
7NPM1, EEF1B2, RPSA, RPL18, RPL13, YBX1, EIF3E
 200
GSE25085_FETAL_LIVER_VS_FETAL_BM_SP4_THYMIC_IMPLANT_UP 1.19e-05 10.54 3.95 8.26e-03 5.79e-02
7BTF3, ICA1, EIF3L, RPL13, EIF3E, NME2, NSA2
 200
GSE6269_FLU_VS_E_COLI_INF_PBMC_DN 4.18e-05 10.78 3.70 2.26e-02 2.04e-01
6EEF1B2, EEF2, BTF3, EIF3L, CCNI, RPL13
 164
GSE3565_DUSP1_VS_WT_SPLENOCYTES_POST_LPS_INJECTION_UP 4.18e-05 10.78 3.70 2.26e-02 2.04e-01
6NPM1, EEF1B2, RPL18, MYC, RPL13, AHCY
 164
GSE3720_LPS_VS_PMA_STIM_VD1_GAMMADELTA_TCELL_DN 5.43e-05 10.27 3.53 2.65e-02 2.65e-01
6EEF1B2, EEF1A1, RPSA, RPL18, MYC, CCNI
 172
GSE3720_UNSTIM_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_UP 5.98e-05 10.09 3.46 2.65e-02 2.91e-01
6EEF1B2, NACA, EEF1A1, RPSA, RPL18, PPP1R14B
 175
GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_UP 1.17e-04 8.88 3.05 3.77e-02 5.71e-01
6EEF1B2, EEF2, NACA, EIF3L, RPL18, RPL13
 198
GSE36009_WT_VS_NLRP10_KO_DC_LPS_STIM_DN 1.20e-04 8.83 3.04 3.77e-02 5.86e-01
6HNRNPA1, ZC2HC1A, EIF4A2, TTC3, RPL13, NSA2
 199
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_4H_DN 1.20e-04 8.83 3.04 3.77e-02 5.86e-01
6NACA, BTF3, EIF3L, RPL18, RPL13, EIF3E
 199
GSE2405_0H_VS_9H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN 1.24e-04 8.78 3.02 3.77e-02 6.03e-01
6NPM1, EEF1B2, RPSA, RPL18, RPL13, YBX1
 200
GSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN 1.24e-04 8.78 3.02 3.77e-02 6.03e-01
6EEF2, RPSA, RPL18, RPL13, YBX1, EIF3E
 200
GSE3565_CTRL_VS_LPS_INJECTED_DUSP1_KO_SPLENOCYTES_DN 5.38e-04 8.37 2.56 1.49e-01 1.00e+00
5EEF1B2, EEF2, RPL18, MYC, TTC3
 171
GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_UP 5.52e-04 8.32 2.54 1.49e-01 1.00e+00
5EEF1B2, MYC, TTC3, RPL13, EIF3E
 172
GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_DN 5.97e-04 8.17 2.50 1.49e-01 1.00e+00
5EEF1B2, EEF2, RPL18, MYC, RPL13
 175
GSE3720_UNSTIM_VS_PMA_STIM_VD1_GAMMADELTA_TCELL_UP 6.12e-04 8.12 2.49 1.49e-01 1.00e+00
5EEF1B2, NACA, RPSA, MYC, NME2
 176

Dowload full table

Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
NPM1 1 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for sequence-specific DNA-binding (PMID: 2223875)
ZFHX4 2 Yes Inferred motif Monomer or homomultimer In vivo/Misc source None Curious protein with numerous C2H2 and homeodomain-like domains.
HNRNPA1 11 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1PGZ)
MEIS2 19 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MYC 30 Yes Known motif Obligate heteromer In vivo/Misc source None Functions as a heterodimer with MAX.
PHB2 34 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein has been shown to bind to TFs and function as a co-repressor. There appears to be no evidence for direct DNA-binding activity (PMID: 18629613)
PHOX2A 36 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
YBX1 40 Yes Known motif Monomer or homomultimer High-throughput in vitro None Might also bind RNA
NME2 42 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds to telomeres (PMID: 22135295). Binds specific sequences by gel-shift, and binding is impacted by a SNP (PMID: 23368879)
HMGA1 54 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
SPDEF 77 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TRIM28 83 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain This protein a well-known co-repressor and is recruited to DNA by KRAB-domain containing TFs. Transfac motifs are likely from interacting proteins
NFATC4 84 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PCBP2 91 No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is an RBP. Structure (PDB:2PQU) is with single stranded DNA
BMP7 116 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HDAC2 122 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Histone deacetylase; likely to be a transcriptional cofactor
CXXC4 123 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds unmethylated CpG-rich sequences: (PMID: 23563267).
APEX1 125 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None The structure (PDB:1DEW) is with abasic DNA - the protein is a base excision repair enzyme that cleaves off abasic bases
ALK 137 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade
FOXO3 142 Yes Known motif Monomer or homomultimer High-throughput in vitro None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
STDY7787237_AAATGCCTCCACGCAG Neurons:adrenal_medulla_cell_line 0.21 1278.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.53, Neuroepithelial_cell:ESC-derived: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.41, Neurons:ES_cell-derived_neural_precursor: 0.41, iPS_cells:PDB_2lox-22: 0.4, iPS_cells:PDB_2lox-21: 0.4
STDY7787237_CTGCTGTAGTCGTACT Neurons:adrenal_medulla_cell_line 0.25 1246.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.58, Neuroepithelial_cell:ESC-derived: 0.48, Astrocyte:Embryonic_stem_cell-derived: 0.47, iPS_cells:PDB_1lox-21Puro-20: 0.47, iPS_cells:PDB_1lox-21Puro-26: 0.47, iPS_cells:PDB_1lox-17Puro-10: 0.47, iPS_cells:PDB_1lox-17Puro-5: 0.46, iPS_cells:PDB_2lox-22: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:PDB_2lox-21: 0.45
STDY7787239_AGGTCCGCAGCCTGTG Neurons:adrenal_medulla_cell_line 0.23 1233.49
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.53, Astrocyte:Embryonic_stem_cell-derived: 0.44, Neuroepithelial_cell:ESC-derived: 0.43, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.41, iPS_cells:PDB_2lox-21: 0.4, iPS_cells:PDB_2lox-22: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.4
STDY7787237_TTTGCGCGTACGACCC Neurons:adrenal_medulla_cell_line 0.18 903.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.48, Astrocyte:Embryonic_stem_cell-derived: 0.39, Neuroepithelial_cell:ESC-derived: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_2lox-21: 0.38, iPS_cells:PDB_2lox-17: 0.38
STDY7787238_TACTCGCGTATATGGA Neurons:adrenal_medulla_cell_line 0.22 755.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.51, Neuroepithelial_cell:ESC-derived: 0.43, iPS_cells:PDB_1lox-21Puro-20: 0.43, iPS_cells:PDB_1lox-21Puro-26: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.42, iPS_cells:PDB_1lox-17Puro-5: 0.42, iPS_cells:PDB_2lox-22: 0.42, iPS_cells:PDB_2lox-21: 0.41, iPS_cells:PDB_2lox-17: 0.41
STDY7787238_GGATTACAGAGGTAGA Neurons:adrenal_medulla_cell_line 0.19 723.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_2lox-17: 0.35
STDY7787239_TTCTCAATCTCTAAGG Neurons:adrenal_medulla_cell_line 0.21 685.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_2lox-17: 0.35
STDY7787238_CCGGTAGAGAGTAAGG Neurons:adrenal_medulla_cell_line 0.19 684.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Astrocyte:Embryonic_stem_cell-derived: 0.4, Neuroepithelial_cell:ESC-derived: 0.4, iPS_cells:PDB_2lox-22: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_2lox-17: 0.37, iPS_cells:PDB_2lox-21: 0.37
STDY7787238_AACCATGCAGATGGCA Neurons:adrenal_medulla_cell_line 0.20 676.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.48, Neuroepithelial_cell:ESC-derived: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_2lox-21: 0.38, iPS_cells:PDB_2lox-17: 0.38
STDY7787237_TACGGTACATACGCCG Neurons:adrenal_medulla_cell_line 0.18 631.22
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.48, Astrocyte:Embryonic_stem_cell-derived: 0.39, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_2lox-22: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, iPS_cells:PDB_2lox-21: 0.37, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.37
STDY7787239_GATCGTATCAGGCCCA Neurons:adrenal_medulla_cell_line 0.22 627.98
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_2lox-21: 0.36, iPS_cells:PDB_2lox-17: 0.36
STDY7787237_TAAGCGTCATAACCTG Neurons:adrenal_medulla_cell_line 0.19 587.86
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.36, iPS_cells:PDB_2lox-22: 0.36, iPS_cells:PDB_2lox-21: 0.36, iPS_cells:PDB_2lox-17: 0.36
STDY7787238_GGAAAGCTCTTCTGGC Neurons:adrenal_medulla_cell_line 0.20 550.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.36, iPS_cells:PDB_1lox-21Puro-26: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.36, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_2lox-17: 0.35
STDY7787239_ACGTCAACAATCCAAC Neurons:adrenal_medulla_cell_line 0.22 549.60
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.5, Astrocyte:Embryonic_stem_cell-derived: 0.4, Neuroepithelial_cell:ESC-derived: 0.4, iPS_cells:PDB_1lox-21Puro-20: 0.39, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, Neurons:ES_cell-derived_neural_precursor: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_2lox-21: 0.37
STDY7787238_CACATTTGTTCTGAAC Neurons:adrenal_medulla_cell_line 0.19 540.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.38, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_2lox-21: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-17: 0.35
STDY7787239_CCTTACGTCACTCCTG Neurons:adrenal_medulla_cell_line 0.20 530.96
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Astrocyte:Embryonic_stem_cell-derived: 0.38, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-22: 0.34
STDY7787238_CTACGTCGTCCGAAGA Neurons:adrenal_medulla_cell_line 0.18 524.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-17: 0.33
STDY7787237_AACGTTGTCGATAGAA Neurons:adrenal_medulla_cell_line 0.22 505.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.52, Neuroepithelial_cell:ESC-derived: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43, iPS_cells:PDB_1lox-21Puro-20: 0.43, iPS_cells:PDB_1lox-21Puro-26: 0.42, iPS_cells:PDB_2lox-22: 0.42, iPS_cells:PDB_1lox-17Puro-10: 0.42, iPS_cells:PDB_1lox-17Puro-5: 0.42, iPS_cells:PDB_2lox-21: 0.42, iPS_cells:PDB_2lox-17: 0.42
STDY7787239_CGGTTAACAAGGCTCC Neurons:adrenal_medulla_cell_line 0.21 485.75
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.48, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, iPS_cells:PDB_2lox-21: 0.37, iPS_cells:PDB_2lox-22: 0.36
STDY7787238_CTGTGCTAGTGAAGAG Neurons:adrenal_medulla_cell_line 0.18 481.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-17: 0.33
STDY7787237_TCGCGAGTCAGCTGGC Neurons:adrenal_medulla_cell_line 0.16 470.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-17: 0.32
STDY7787239_GGAACTTAGGGCACTA Neurons:adrenal_medulla_cell_line 0.20 433.72
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.35, Neurons:ES_cell-derived_neural_precursor: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-21: 0.34
STDY7787239_GACGTTACATGGTAGG Neurons:adrenal_medulla_cell_line 0.20 431.95
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-17: 0.34
STDY7787238_GGTGTTACAATAGAGT Neurons:adrenal_medulla_cell_line 0.18 430.21
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-17: 0.33
STDY7787238_GGATTACGTGCGCTTG Neurons:adrenal_medulla_cell_line 0.15 400.02
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neuroepithelial_cell:ESC-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_2lox-21: 0.29, iPS_cells:iPS:minicircle-derived: 0.29
STDY7787237_CACATAGTCTATGTGG Neurons:adrenal_medulla_cell_line 0.17 398.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-17: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.34
STDY7787238_GTTACAGAGCAAATCA Neurons:adrenal_medulla_cell_line 0.18 388.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-17: 0.33
STDY7787239_ATGTGTGAGTCCTCCT Neurons:adrenal_medulla_cell_line 0.18 375.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-17: 0.33, iPS_cells:PDB_2lox-21: 0.33
STDY7787237_TTCTACAAGCGTCTAT Neurons:adrenal_medulla_cell_line 0.19 370.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.39, iPS_cells:PDB_1lox-21Puro-26: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.39, iPS_cells:PDB_1lox-17Puro-5: 0.39, Neurons:ES_cell-derived_neural_precursor: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_2lox-21: 0.38
STDY7787239_GGTATTGGTTGTACAC Neurons:adrenal_medulla_cell_line 0.19 369.41
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-17: 0.33
STDY7787237_ACGGGTCAGAAGGTGA Neurons:adrenal_medulla_cell_line 0.19 360.48
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.37, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_2lox-5: 0.34
STDY7787239_TCAGCAAAGGCTAGCA Neurons:adrenal_medulla_cell_line 0.17 357.13
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-17: 0.31
STDY7787238_CTAGAGTTCTGAGTGT Neurons:adrenal_medulla_cell_line 0.23 352.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.5, Neuroepithelial_cell:ESC-derived: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.42, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.41, iPS_cells:PDB_2lox-22: 0.41, Neurons:ES_cell-derived_neural_precursor: 0.4, iPS_cells:PDB_2lox-21: 0.4
STDY7787238_GACTGCGCAATCCAAC Neurons:adrenal_medulla_cell_line 0.17 342.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-17: 0.31
STDY7787239_CTTACCGTCACTTATC Neurons:adrenal_medulla_cell_line 0.24 340.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.5, Neuroepithelial_cell:ESC-derived: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.4, iPS_cells:PDB_1lox-21Puro-26: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.39, iPS_cells:PDB_1lox-17Puro-5: 0.39, Neurons:ES_cell-derived_neural_precursor: 0.39, iPS_cells:PDB_2lox-22: 0.39, Embryonic_stem_cells: 0.39
STDY7787237_TACGGGCGTTCACCTC Neurons:adrenal_medulla_cell_line 0.18 321.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-17: 0.34
STDY7787239_TCTCTAACAACACCCG Neurons:adrenal_medulla_cell_line 0.25 320.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.5, Neuroepithelial_cell:ESC-derived: 0.43, Astrocyte:Embryonic_stem_cell-derived: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_1lox-17Puro-5: 0.4, iPS_cells:PDB_2lox-22: 0.4, Neurons:ES_cell-derived_neural_precursor: 0.4, iPS_cells:PDB_2lox-21: 0.4
STDY7787237_ATCCGAAAGGTGACCA Neurons:adrenal_medulla_cell_line 0.17 318.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-21: 0.31
STDY7787238_CGAGCACTCCAAAGTC Neurons:adrenal_medulla_cell_line 0.20 314.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.45, Neuroepithelial_cell:ESC-derived: 0.38, iPS_cells:PDB_1lox-21Puro-20: 0.37, iPS_cells:PDB_1lox-21Puro-26: 0.37, iPS_cells:PDB_2lox-22: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, iPS_cells:PDB_1lox-17Puro-10: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.36, iPS_cells:PDB_2lox-21: 0.36, iPS_cells:PDB_2lox-17: 0.36
STDY7787239_CCAGCGACATCCTTGC Neurons:adrenal_medulla_cell_line 0.25 314.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.48, Neuroepithelial_cell:ESC-derived: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.37, iPS_cells:PDB_1lox-17Puro-5: 0.37, Neurons:ES_cell-derived_neural_precursor: 0.37, Embryonic_stem_cells: 0.36, iPS_cells:PDB_2lox-22: 0.36
STDY7787238_AAGGTTCCATAGTAAG Neurons:adrenal_medulla_cell_line 0.18 313.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neuroepithelial_cell:ESC-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_2lox-21: 0.3, iPS_cells:PDB_2lox-17: 0.3
STDY7787238_CAAGATCGTCCGAACC Neurons:adrenal_medulla_cell_line 0.22 309.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.49, Astrocyte:Embryonic_stem_cell-derived: 0.43, Neuroepithelial_cell:ESC-derived: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.39, iPS_cells:PDB_1lox-21Puro-26: 0.39, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_2lox-22: 0.38, iPS_cells:PDB_2lox-21: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38
STDY7787238_TCGCGAGAGATGAGAG Neurons:adrenal_medulla_cell_line 0.17 307.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_2lox-21: 0.28, iPS_cells:PDB_2lox-17: 0.28
STDY7787237_CGGTTAACAGGAACGT Neurons:adrenal_medulla_cell_line 0.14 302.61
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neuroepithelial_cell:ESC-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.31, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_2lox-21: 0.3
STDY7787237_TTGCGTCCAATGGAGC Neurons:adrenal_medulla_cell_line 0.16 299.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Astrocyte:Embryonic_stem_cell-derived: 0.35, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-21: 0.32
STDY7787237_GTACGTATCCTAGGGC Neurons:adrenal_medulla_cell_line 0.18 298.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.43, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:iPS:minicircle-derived: 0.33
STDY7787237_GGGCACTGTATAGTAG Neurons:adrenal_medulla_cell_line 0.14 295.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.27, iPS_cells:PDB_2lox-17: 0.27
STDY7787238_CTGCGGACATGAGCGA Neurons:adrenal_medulla_cell_line 0.18 294.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_2lox-21: 0.32
STDY7787238_GTTTCTAGTGAAAGAG Neurons:adrenal_medulla_cell_line 0.22 291.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.47, Neuroepithelial_cell:ESC-derived: 0.4, Astrocyte:Embryonic_stem_cell-derived: 0.4, iPS_cells:PDB_1lox-21Puro-20: 0.39, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, iPS_cells:PDB_2lox-22: 0.38, Embryonic_stem_cells: 0.38, iPS_cells:PDB_2lox-21: 0.38
STDY7787239_GTCATTTCATACTACG Neurons:adrenal_medulla_cell_line 0.19 290.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:iPS:minicircle-derived: 0.33


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Symphathoblasts (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. Several of these markers are also (more weakly) expressed in chromaffin cells. The authors data suggest Symphthoblasts give rise to chromaffin cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.11e-04
Mean rank of genes in gene set: 418.5
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ELAVL3 0.0032317 127 GTEx DepMap Descartes 3.44 154.55
ISL1 0.0024248 253 GTEx DepMap Descartes 3.02 317.97
STMN2 0.0022958 275 GTEx DepMap Descartes 60.80 6980.94
ELAVL4 0.0009324 1019 GTEx DepMap Descartes 6.58 358.53


Symphathoblasts Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for symphathoblasts (differentiating from SCPs):
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.12e-04
Mean rank of genes in gene set: 1107.8
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ISL1 0.0024248 253 GTEx DepMap Descartes 3.02 317.97
STMN2 0.0022958 275 GTEx DepMap Descartes 60.80 6980.94
HAND2 0.0022286 292 GTEx DepMap Descartes 5.40 485.67
ELAVL4 0.0009324 1019 GTEx DepMap Descartes 6.58 358.53
ELAVL2 0.0001330 3700 GTEx DepMap Descartes 1.70 86.72


N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.04e-03
Mean rank of genes in gene set: 3487.69
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
SCG5 0.0027304 185 GTEx DepMap Descartes 3.58 774.29
SCG3 0.0017089 467 GTEx DepMap Descartes 2.72 218.33
SLCO3A1 0.0013775 641 GTEx DepMap Descartes 2.04 101.04
CACNA2D1 0.0012416 725 GTEx DepMap Descartes 0.95 38.04
ADCYAP1R1 0.0011640 793 GTEx DepMap Descartes 0.24 8.56
GNAS 0.0007491 1300 GTEx DepMap Descartes 18.03 1001.51
PPFIA2 0.0007486 1302 GTEx DepMap Descartes 0.29 14.76
CELF4 0.0006602 1493 GTEx DepMap Descartes 3.17 185.50
NAP1L5 0.0004350 2147 GTEx DepMap Descartes 0.79 110.95
SNAP25 0.0004229 2189 GTEx DepMap Descartes 2.70 250.97
LGR5 -0.0000332 5298 GTEx DepMap Descartes 0.01 0.38
PCLO -0.0000656 5806 GTEx DepMap Descartes 0.86 9.56
SYN2 -0.0001152 6610 GTEx DepMap Descartes 0.04 1.97
CXCL14 -0.0001422 7051 GTEx DepMap Descartes 0.12 15.17
PTPRN -0.0002042 8000 GTEx DepMap Descartes 0.43 14.22
C1QL1 -0.0007154 11796 GTEx DepMap Descartes 0.13 11.69




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.02e-21
Mean rank of genes in gene set: 4327.93
Median rank of genes in gene set: 2297
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PKIA 0.0071768 8 GTEx DepMap Descartes 8.91 506.47
ICA1 0.0064615 16 GTEx DepMap Descartes 7.34 795.28
GAL 0.0054785 26 GTEx DepMap Descartes 17.53 5514.95
GLCCI1 0.0050009 32 GTEx DepMap Descartes 5.04 261.82
CCNI 0.0049622 33 GTEx DepMap Descartes 22.13 1804.42
PHOX2A 0.0048503 36 GTEx DepMap Descartes 7.94 1160.99
OLA1 0.0044593 51 GTEx DepMap Descartes 5.42 284.70
BMPR1B 0.0044232 53 GTEx DepMap Descartes 3.29 169.35
HMGA1 0.0043946 54 GTEx DepMap Descartes 6.60 687.19
DDC 0.0042436 61 GTEx DepMap Descartes 4.00 462.11
SYT1 0.0041890 65 GTEx DepMap Descartes 6.61 331.29
RBP1 0.0041687 68 GTEx DepMap Descartes 8.31 1011.19
GGCT 0.0040951 70 GTEx DepMap Descartes 4.76 947.37
ARHGEF7 0.0040467 72 GTEx DepMap Descartes 4.81 176.34
IRS2 0.0039453 76 GTEx DepMap Descartes 7.86 246.66
REC8 0.0037610 85 GTEx DepMap Descartes 2.09 177.96
NELL2 0.0036839 95 GTEx DepMap Descartes 2.87 182.66
GABRB3 0.0034401 111 GTEx DepMap Descartes 1.28 50.58
BMP7 0.0033398 116 GTEx DepMap Descartes 0.67 39.46
KLHL23 0.0032602 124 GTEx DepMap Descartes 3.09 173.36
ELAVL3 0.0032317 127 GTEx DepMap Descartes 3.44 154.55
ATCAY 0.0031853 134 GTEx DepMap Descartes 1.83 81.30
TMEM97 0.0031685 136 GTEx DepMap Descartes 1.80 153.62
ALK 0.0031661 137 GTEx DepMap Descartes 0.52 22.11
FOXO3 0.0031167 142 GTEx DepMap Descartes 3.70 134.55
TFAP2B 0.0030848 144 GTEx DepMap Descartes 4.31 209.60
POPDC3 0.0029123 163 GTEx DepMap Descartes 0.37 45.68
GRIA2 0.0028485 171 GTEx DepMap Descartes 2.07 106.18
LRRTM2 0.0028439 172 GTEx DepMap Descartes 0.90 37.97
FKBP4 0.0027984 176 GTEx DepMap Descartes 2.68 183.30


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9024.03
Median rank of genes in gene set: 9941
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ENAH 0.0033982 112 GTEx DepMap Descartes 3.09 55.84
MEST 0.0030756 146 GTEx DepMap Descartes 2.61 265.21
GAS2 0.0025010 233 GTEx DepMap Descartes 0.09 7.11
LAMB1 0.0018501 420 GTEx DepMap Descartes 1.02 48.39
NES 0.0017679 443 GTEx DepMap Descartes 1.51 70.46
COL11A1 0.0017303 455 GTEx DepMap Descartes 0.39 12.28
CTNNA1 0.0017150 462 GTEx DepMap Descartes 1.68 104.23
ALDH1A3 0.0016642 494 GTEx DepMap Descartes 0.28 22.67
TMEFF2 0.0011092 834 GTEx DepMap Descartes 1.76 134.46
PDE3A 0.0010108 935 GTEx DepMap Descartes 0.13 4.05
SCRG1 0.0009885 964 GTEx DepMap Descartes 0.55 44.85
STAT1 0.0008947 1073 GTEx DepMap Descartes 2.44 147.94
CTDSP2 0.0008810 1095 GTEx DepMap Descartes 0.96 49.83
SERPINE2 0.0008447 1146 GTEx DepMap Descartes 1.58 64.65
FZD1 0.0008168 1188 GTEx DepMap Descartes 0.19 6.16
CALD1 0.0008104 1200 GTEx DepMap Descartes 3.33 189.33
KDM5B 0.0007852 1239 GTEx DepMap Descartes 0.98 25.63
TPM1 0.0007640 1272 GTEx DepMap Descartes 2.28 137.85
CKAP4 0.0005651 1733 GTEx DepMap Descartes 1.18 94.91
TJP1 0.0005365 1814 GTEx DepMap Descartes 0.45 13.09
JAM3 0.0005289 1836 GTEx DepMap Descartes 0.26 16.93
SLC39A14 0.0005038 1913 GTEx DepMap Descartes 0.24 11.83
SSBP4 0.0004793 1994 GTEx DepMap Descartes 1.58 210.50
NFIC 0.0004681 2033 GTEx DepMap Descartes 0.65 18.31
LMAN1 0.0004525 2093 GTEx DepMap Descartes 1.44 75.88
ATP1B1 0.0003923 2313 GTEx DepMap Descartes 4.59 336.13
PRDX6 0.0003497 2491 GTEx DepMap Descartes 2.61 335.91
HIBADH 0.0003406 2523 GTEx DepMap Descartes 0.46 64.37
TPM2 0.0002914 2728 GTEx DepMap Descartes 0.90 145.03
FKBP14 0.0002764 2807 GTEx DepMap Descartes 0.13 2.96


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.59e-01
Mean rank of genes in gene set: 7323.42
Median rank of genes in gene set: 7738.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GSTA4 0.0009560 998 GTEx DepMap Descartes 1.38 188.60
SLC1A2 0.0008397 1155 GTEx DepMap Descartes 0.27 6.16
JAKMIP2 0.0006141 1612 GTEx DepMap Descartes 0.65 14.12
SLC16A9 0.0004838 1974 GTEx DepMap Descartes 0.19 10.55
FRMD5 0.0004785 1997 GTEx DepMap Descartes 0.10 4.93
GRAMD1B 0.0002553 2931 GTEx DepMap Descartes 0.11 3.65
SCARB1 0.0002271 3079 GTEx DepMap Descartes 0.41 17.65
PDE10A 0.0002000 3253 GTEx DepMap Descartes 0.10 3.20
SGCZ -0.0000086 5037 GTEx DepMap Descartes 0.00 0.00
SCAP -0.0000236 5176 GTEx DepMap Descartes 0.20 12.32
FREM2 -0.0000422 5424 GTEx DepMap Descartes 0.00 0.00
TM7SF2 -0.0000476 5501 GTEx DepMap Descartes 0.34 35.16
BAIAP2L1 -0.0000559 5629 GTEx DepMap Descartes 0.02 2.20
MSMO1 -0.0000651 5795 GTEx DepMap Descartes 0.43 39.45
DHCR24 -0.0000677 5833 GTEx DepMap Descartes 0.38 12.77
DHCR7 -0.0001155 6617 GTEx DepMap Descartes 0.19 16.35
HMGCR -0.0001229 6742 GTEx DepMap Descartes 0.27 11.24
IGF1R -0.0001416 7037 GTEx DepMap Descartes 0.30 5.74
CLU -0.0002339 8440 GTEx DepMap Descartes 3.82 364.57
SH3PXD2B -0.0002633 8828 GTEx DepMap Descartes 0.05 1.42
NPC1 -0.0002766 8990 GTEx DepMap Descartes 0.10 3.96
STAR -0.0002770 8994 GTEx DepMap Descartes 0.07 5.42
PEG3 -0.0003578 9922 GTEx DepMap Descartes 0.21 NA
PAPSS2 -0.0003694 10012 GTEx DepMap Descartes 0.01 0.06
LDLR -0.0003932 10203 GTEx DepMap Descartes 0.10 4.62
INHA -0.0003972 10236 GTEx DepMap Descartes 0.01 0.96
APOC1 -0.0004073 10313 GTEx DepMap Descartes 2.63 282.81
ERN1 -0.0004268 10485 GTEx DepMap Descartes 0.06 1.46
POR -0.0004983 10909 GTEx DepMap Descartes 0.28 25.62
CYB5B -0.0005300 11079 GTEx DepMap Descartes 0.50 29.27


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.07e-03
Mean rank of genes in gene set: 4540.76
Median rank of genes in gene set: 2209
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IL7 0.0070711 9 GTEx DepMap Descartes 8.03 947.57
GAL 0.0054785 26 GTEx DepMap Descartes 17.53 5514.95
EYA4 0.0036362 97 GTEx DepMap Descartes 1.17 56.27
ALK 0.0031661 137 GTEx DepMap Descartes 0.52 22.11
MAB21L2 0.0025879 218 GTEx DepMap Descartes 0.88 84.32
ISL1 0.0024248 253 GTEx DepMap Descartes 3.02 317.97
STMN2 0.0022958 275 GTEx DepMap Descartes 60.80 6980.94
RBFOX1 0.0020362 344 GTEx DepMap Descartes 1.18 49.91
CCND1 0.0016987 472 GTEx DepMap Descartes 8.21 523.27
EYA1 0.0016763 488 GTEx DepMap Descartes 0.49 30.65
SLC44A5 0.0015246 566 GTEx DepMap Descartes 0.52 28.61
RYR2 0.0013797 640 GTEx DepMap Descartes 0.40 6.27
SLC6A2 0.0013236 671 GTEx DepMap Descartes 0.48 31.01
TUBB2B 0.0011765 778 GTEx DepMap Descartes 19.72 2404.78
TMEFF2 0.0011092 834 GTEx DepMap Descartes 1.76 134.46
CNKSR2 0.0008973 1066 GTEx DepMap Descartes 0.33 9.22
PTCHD1 0.0008826 1092 GTEx DepMap Descartes 0.51 10.20
TMEM132C 0.0008165 1191 GTEx DepMap Descartes 0.25 14.81
MARCH11 0.0006393 1553 GTEx DepMap Descartes 0.59 NA
CNTFR 0.0005724 1711 GTEx DepMap Descartes 1.46 188.51
FAT3 0.0004184 2209 GTEx DepMap Descartes 0.15 2.42
PLXNA4 0.0001980 3269 GTEx DepMap Descartes 0.53 8.78
RGMB 0.0001823 3367 GTEx DepMap Descartes 0.95 42.76
ANKFN1 0.0001433 3629 GTEx DepMap Descartes 0.12 7.72
ELAVL2 0.0001330 3700 GTEx DepMap Descartes 1.70 86.72
MAP1B 0.0000392 4514 GTEx DepMap Descartes 12.84 217.83
KCNB2 -0.0001140 6591 GTEx DepMap Descartes 0.07 4.05
EPHA6 -0.0001808 7667 GTEx DepMap Descartes 0.04 2.04
SYNPO2 -0.0002061 8023 GTEx DepMap Descartes 0.13 1.22
RPH3A -0.0002217 8256 GTEx DepMap Descartes 0.05 1.14


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.94e-01
Mean rank of genes in gene set: 7735.05
Median rank of genes in gene set: 8376.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IRX3 0.0007394 1316 GTEx DepMap Descartes 0.13 10.70
RAMP2 0.0003541 2474 GTEx DepMap Descartes 1.48 402.57
ARHGAP29 0.0001632 3505 GTEx DepMap Descartes 0.57 13.99
EHD3 0.0000457 4460 GTEx DepMap Descartes 0.10 4.76
CEACAM1 -0.0000225 5164 GTEx DepMap Descartes 0.11 8.19
PODXL -0.0000439 5442 GTEx DepMap Descartes 0.10 5.24
GALNT15 -0.0000613 5732 GTEx DepMap Descartes 0.01 NA
MYRIP -0.0000772 5978 GTEx DepMap Descartes 0.04 0.89
NR5A2 -0.0001454 7110 GTEx DepMap Descartes 0.00 0.00
CYP26B1 -0.0001524 7232 GTEx DepMap Descartes 0.01 0.11
CHRM3 -0.0001559 7296 GTEx DepMap Descartes 0.28 4.82
SHE -0.0001612 7391 GTEx DepMap Descartes 0.01 0.34
ESM1 -0.0001665 7478 GTEx DepMap Descartes 0.02 0.52
CRHBP -0.0001891 7776 GTEx DepMap Descartes 0.00 0.00
CDH13 -0.0001943 7848 GTEx DepMap Descartes 0.04 0.63
SHANK3 -0.0001963 7866 GTEx DepMap Descartes 0.03 0.74
BTNL9 -0.0001995 7923 GTEx DepMap Descartes 0.03 2.14
FLT4 -0.0002005 7944 GTEx DepMap Descartes 0.00 0.00
KDR -0.0002224 8267 GTEx DepMap Descartes 0.00 0.00
TEK -0.0002374 8486 GTEx DepMap Descartes 0.00 0.00
SLCO2A1 -0.0002376 8495 GTEx DepMap Descartes 0.00 0.00
KANK3 -0.0002398 8524 GTEx DepMap Descartes 0.01 0.48
NOTCH4 -0.0002489 8631 GTEx DepMap Descartes 0.13 4.30
F8 -0.0002549 8714 GTEx DepMap Descartes 0.00 0.00
NPR1 -0.0002570 8746 GTEx DepMap Descartes 0.00 0.00
HYAL2 -0.0002652 8850 GTEx DepMap Descartes 0.29 15.02
ROBO4 -0.0002687 8898 GTEx DepMap Descartes 0.03 1.55
MMRN2 -0.0002744 8970 GTEx DepMap Descartes 0.01 0.10
RASIP1 -0.0002748 8974 GTEx DepMap Descartes 0.00 0.00
PTPRB -0.0002767 8991 GTEx DepMap Descartes 0.02 0.24


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8204.55
Median rank of genes in gene set: 8976
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GAS2 0.0025010 233 GTEx DepMap Descartes 0.09 7.11
PCOLCE 0.0007205 1349 GTEx DepMap Descartes 1.46 249.94
LAMC3 0.0000940 4024 GTEx DepMap Descartes 0.01 0.31
COL27A1 0.0000203 4719 GTEx DepMap Descartes 0.02 0.66
ADAMTS2 -0.0000007 4949 GTEx DepMap Descartes 0.11 4.06
GLI2 -0.0000497 5535 GTEx DepMap Descartes 0.01 0.23
FREM1 -0.0000627 5755 GTEx DepMap Descartes 0.02 0.36
PRICKLE1 -0.0000874 6127 GTEx DepMap Descartes 0.13 4.50
LRRC17 -0.0000902 6173 GTEx DepMap Descartes 0.06 4.33
ITGA11 -0.0001233 6745 GTEx DepMap Descartes 0.05 1.16
ADAMTSL3 -0.0001320 6881 GTEx DepMap Descartes 0.03 0.99
CLDN11 -0.0001825 7694 GTEx DepMap Descartes 0.05 2.67
RSPO3 -0.0002056 8018 GTEx DepMap Descartes 0.00 NA
DKK2 -0.0002081 8060 GTEx DepMap Descartes 0.00 0.00
PAMR1 -0.0002140 8145 GTEx DepMap Descartes 0.02 0.65
SFRP2 -0.0002171 8188 GTEx DepMap Descartes 0.01 0.12
EDNRA -0.0002295 8370 GTEx DepMap Descartes 0.00 0.00
SCARA5 -0.0002319 8399 GTEx DepMap Descartes 0.00 0.00
C7 -0.0002649 8847 GTEx DepMap Descartes 0.00 0.00
PCDH18 -0.0002659 8859 GTEx DepMap Descartes 0.01 0.74
BICC1 -0.0002714 8931 GTEx DepMap Descartes 0.03 1.65
ABCC9 -0.0002732 8951 GTEx DepMap Descartes 0.01 0.17
COL6A3 -0.0002776 9001 GTEx DepMap Descartes 0.15 3.04
IGFBP3 -0.0002912 9165 GTEx DepMap Descartes 0.06 5.24
PDGFRA -0.0003010 9264 GTEx DepMap Descartes 0.00 0.00
ACTA2 -0.0003037 9291 GTEx DepMap Descartes 0.11 24.70
ISLR -0.0003041 9294 GTEx DepMap Descartes 0.00 0.00
PRRX1 -0.0003045 9304 GTEx DepMap Descartes 0.00 0.00
ABCA6 -0.0003214 9514 GTEx DepMap Descartes 0.00 0.00
POSTN -0.0003231 9536 GTEx DepMap Descartes 0.01 0.08


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.59e-03
Mean rank of genes in gene set: 4697.68
Median rank of genes in gene set: 4266
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FGF14 0.0029090 165 GTEx DepMap Descartes 0.80 17.36
NTNG1 0.0024592 245 GTEx DepMap Descartes 0.58 30.86
KSR2 0.0023915 260 GTEx DepMap Descartes 0.20 3.35
GALNTL6 0.0022800 282 GTEx DepMap Descartes 0.25 19.64
CHGA 0.0022098 300 GTEx DepMap Descartes 3.67 456.03
CCSER1 0.0018801 405 GTEx DepMap Descartes 0.35 NA
PCSK2 0.0010634 880 GTEx DepMap Descartes 0.16 9.37
TENM1 0.0009542 1002 GTEx DepMap Descartes 0.29 NA
UNC80 0.0008710 1109 GTEx DepMap Descartes 0.54 9.86
TIAM1 0.0008347 1162 GTEx DepMap Descartes 0.46 15.34
KCTD16 0.0008167 1189 GTEx DepMap Descartes 0.78 15.29
EML6 0.0007201 1352 GTEx DepMap Descartes 0.21 5.10
SPOCK3 0.0005600 1748 GTEx DepMap Descartes 0.58 44.31
CDH18 0.0005165 1873 GTEx DepMap Descartes 0.15 7.71
MGAT4C 0.0004450 2115 GTEx DepMap Descartes 0.30 2.31
CDH12 0.0002063 3215 GTEx DepMap Descartes 0.12 5.44
FAM155A 0.0001436 3628 GTEx DepMap Descartes 0.26 5.70
TBX20 0.0000789 4167 GTEx DepMap Descartes 0.03 5.50
DGKK 0.0000684 4249 GTEx DepMap Descartes 0.07 3.23
GRID2 0.0000652 4283 GTEx DepMap Descartes 0.05 1.89
CHGB -0.0000155 5101 GTEx DepMap Descartes 4.76 460.31
SLC35F3 -0.0000265 5214 GTEx DepMap Descartes 0.04 2.44
ARC -0.0000369 5345 GTEx DepMap Descartes 0.31 26.88
AGBL4 -0.0000579 5666 GTEx DepMap Descartes 0.02 1.49
ST18 -0.0000957 6262 GTEx DepMap Descartes 0.00 0.00
LAMA3 -0.0001388 6996 GTEx DepMap Descartes 0.03 1.15
PCSK1N -0.0001395 7004 GTEx DepMap Descartes 5.47 1109.07
PENK -0.0001482 7157 GTEx DepMap Descartes 0.00 0.00
SLC24A2 -0.0001493 7171 GTEx DepMap Descartes 0.01 0.23
GRM7 -0.0001635 7430 GTEx DepMap Descartes 0.02 0.46


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.92e-01
Mean rank of genes in gene set: 6822.55
Median rank of genes in gene set: 6633
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TFR2 0.0024473 250 GTEx DepMap Descartes 0.66 51.77
SOX6 0.0008311 1173 GTEx DepMap Descartes 0.29 9.47
TSPAN5 0.0007640 1271 GTEx DepMap Descartes 0.97 55.81
XPO7 0.0002403 3003 GTEx DepMap Descartes 0.41 19.08
SPTB 0.0001591 3531 GTEx DepMap Descartes 0.08 2.14
DENND4A 0.0000458 4458 GTEx DepMap Descartes 0.49 16.08
FECH 0.0000232 4688 GTEx DepMap Descartes 0.31 8.64
GCLC -0.0000176 5121 GTEx DepMap Descartes 0.23 13.68
RHD -0.0000373 5353 GTEx DepMap Descartes 0.02 1.24
SLC25A37 -0.0000485 5513 GTEx DepMap Descartes 0.93 53.77
SLC25A21 -0.0000689 5857 GTEx DepMap Descartes 0.00 0.00
SNCA -0.0000711 5891 GTEx DepMap Descartes 0.76 45.83
ALAS2 -0.0001114 6548 GTEx DepMap Descartes 0.00 0.00
ABCB10 -0.0001125 6564 GTEx DepMap Descartes 0.11 7.97
RGS6 -0.0001166 6633 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0001402 7016 GTEx DepMap Descartes 0.01 0.63
ANK1 -0.0001548 7272 GTEx DepMap Descartes 0.10 2.88
RAPGEF2 -0.0001840 7713 GTEx DepMap Descartes 0.21 4.95
SELENBP1 -0.0002430 8559 GTEx DepMap Descartes 0.01 0.33
TMCC2 -0.0002476 8616 GTEx DepMap Descartes 0.03 1.82
SPECC1 -0.0002745 8971 GTEx DepMap Descartes 0.07 1.94
MICAL2 -0.0002794 9017 GTEx DepMap Descartes 0.03 0.72
CPOX -0.0002966 9221 GTEx DepMap Descartes 0.06 3.54
TRAK2 -0.0003274 9583 GTEx DepMap Descartes 0.16 4.64
MARCH3 -0.0003300 9614 GTEx DepMap Descartes 0.04 NA
CAT -0.0004631 10709 GTEx DepMap Descartes 0.45 58.23
EPB41 -0.0005858 11365 GTEx DepMap Descartes 0.20 7.24
BLVRB -0.0007640 11897 GTEx DepMap Descartes 0.27 22.08
GYPC -0.0013452 12447 GTEx DepMap Descartes 0.06 9.34
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10318.26
Median rank of genes in gene set: 11109
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD163L1 0.0025308 226 GTEx DepMap Descartes 2.01 104.37
RBPJ 0.0002874 2755 GTEx DepMap Descartes 1.71 71.84
HRH1 0.0000164 4772 GTEx DepMap Descartes 0.03 1.99
RGL1 -0.0001673 7490 GTEx DepMap Descartes 0.07 3.23
ATP8B4 -0.0002392 8515 GTEx DepMap Descartes 0.00 0.00
MSR1 -0.0002763 8988 GTEx DepMap Descartes 0.02 0.57
SPP1 -0.0002916 9168 GTEx DepMap Descartes 0.41 40.56
SLC1A3 -0.0003149 9426 GTEx DepMap Descartes 0.02 0.25
MERTK -0.0003155 9434 GTEx DepMap Descartes 0.00 0.00
SLCO2B1 -0.0003370 9696 GTEx DepMap Descartes 0.02 0.36
ABCA1 -0.0003669 9994 GTEx DepMap Descartes 0.12 1.84
WWP1 -0.0003996 10255 GTEx DepMap Descartes 0.07 2.46
SLC9A9 -0.0004372 10554 GTEx DepMap Descartes 0.02 1.10
ADAP2 -0.0004400 10570 GTEx DepMap Descartes 0.01 0.98
LGMN -0.0004689 10743 GTEx DepMap Descartes 0.31 19.83
SFMBT2 -0.0004703 10755 GTEx DepMap Descartes 0.00 0.00
MS4A4A -0.0004738 10778 GTEx DepMap Descartes 0.02 0.45
AXL -0.0004826 10831 GTEx DepMap Descartes 0.07 1.49
CD163 -0.0005111 10982 GTEx DepMap Descartes 0.01 0.47
FMN1 -0.0005583 11236 GTEx DepMap Descartes 0.08 0.86
FGD2 -0.0005594 11243 GTEx DepMap Descartes 0.08 2.84
CSF1R -0.0006002 11407 GTEx DepMap Descartes 0.02 0.25
ITPR2 -0.0006010 11409 GTEx DepMap Descartes 0.04 0.49
CTSD -0.0006665 11651 GTEx DepMap Descartes 1.26 112.50
TGFBI -0.0006782 11687 GTEx DepMap Descartes 0.01 0.23
MARCH1 -0.0006792 11690 GTEx DepMap Descartes 0.04 NA
CD14 -0.0006920 11731 GTEx DepMap Descartes 0.05 7.25
CPVL -0.0007740 11916 GTEx DepMap Descartes 0.05 3.06
CYBB -0.0007965 11966 GTEx DepMap Descartes 0.09 3.26
FGL2 -0.0008188 12007 GTEx DepMap Descartes 0.08 2.34


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-01
Mean rank of genes in gene set: 7029.82
Median rank of genes in gene set: 6742
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ERBB4 0.0039742 74 GTEx DepMap Descartes 0.79 16.94
MARCKS 0.0027086 191 GTEx DepMap Descartes 12.73 731.73
LAMB1 0.0018501 420 GTEx DepMap Descartes 1.02 48.39
DST 0.0010189 929 GTEx DepMap Descartes 2.94 35.67
FIGN 0.0004725 2016 GTEx DepMap Descartes 0.24 6.95
SOX5 0.0002998 2690 GTEx DepMap Descartes 0.12 3.15
GFRA3 0.0002356 3037 GTEx DepMap Descartes 1.26 146.36
PLCE1 0.0002207 3125 GTEx DepMap Descartes 0.20 3.98
SLC35F1 0.0001927 3300 GTEx DepMap Descartes 0.13 5.86
SFRP1 0.0001722 3441 GTEx DepMap Descartes 1.28 63.38
ERBB3 0.0001685 3466 GTEx DepMap Descartes 0.02 0.64
NRXN3 0.0000497 4426 GTEx DepMap Descartes 0.02 0.34
IL1RAPL2 0.0000227 4694 GTEx DepMap Descartes 0.00 0.00
EGFLAM -0.0000377 5358 GTEx DepMap Descartes 0.04 1.25
COL25A1 -0.0000646 5789 GTEx DepMap Descartes 0.00 0.00
PTPRZ1 -0.0000723 5916 GTEx DepMap Descartes 0.00 0.00
MDGA2 -0.0000940 6228 GTEx DepMap Descartes 0.02 0.19
STARD13 -0.0001036 6400 GTEx DepMap Descartes 0.01 0.14
HMGA2 -0.0001038 6405 GTEx DepMap Descartes 0.01 0.30
GRIK3 -0.0001112 6543 GTEx DepMap Descartes 0.02 0.58
XKR4 -0.0001123 6558 GTEx DepMap Descartes 0.09 1.40
TRPM3 -0.0001142 6593 GTEx DepMap Descartes 0.13 1.69
MPZ -0.0001328 6891 GTEx DepMap Descartes 0.02 1.50
PLP1 -0.0002135 8135 GTEx DepMap Descartes 0.00 0.00
LRRTM4 -0.0002463 8599 GTEx DepMap Descartes 0.14 6.19
IL1RAPL1 -0.0002519 8674 GTEx DepMap Descartes 0.00 0.00
ADAMTS5 -0.0002589 8772 GTEx DepMap Descartes 0.01 0.19
NRXN1 -0.0002774 8998 GTEx DepMap Descartes 0.55 8.74
OLFML2A -0.0002840 9086 GTEx DepMap Descartes 0.01 0.77
SORCS1 -0.0002966 9222 GTEx DepMap Descartes 0.08 1.66


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9312.71
Median rank of genes in gene set: 10620
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PDE3A 0.0010108 935 GTEx DepMap Descartes 0.13 4.05
RAB27B 0.0006617 1490 GTEx DepMap Descartes 0.35 11.06
MED12L 0.0005895 1667 GTEx DepMap Descartes 0.05 1.26
HIPK2 0.0004723 2017 GTEx DepMap Descartes 0.90 13.93
ITGA2B 0.0000366 4539 GTEx DepMap Descartes 0.04 2.65
GP1BA -0.0000045 4992 GTEx DepMap Descartes 0.03 2.38
DOK6 -0.0000364 5339 GTEx DepMap Descartes 0.12 2.58
TUBB1 -0.0000482 5512 GTEx DepMap Descartes 0.03 2.14
SLC24A3 -0.0001208 6711 GTEx DepMap Descartes 0.00 0.00
ITGB3 -0.0001404 7021 GTEx DepMap Descartes 0.00 0.00
ANGPT1 -0.0001434 7069 GTEx DepMap Descartes 0.01 0.58
TRPC6 -0.0001744 7586 GTEx DepMap Descartes 0.00 0.00
ARHGAP6 -0.0001787 7636 GTEx DepMap Descartes 0.00 0.00
PRKAR2B -0.0002200 8230 GTEx DepMap Descartes 0.56 30.85
MMRN1 -0.0002451 8588 GTEx DepMap Descartes 0.00 0.00
STON2 -0.0002619 8803 GTEx DepMap Descartes 0.08 2.88
MYLK -0.0002811 9045 GTEx DepMap Descartes 0.03 0.56
LTBP1 -0.0003203 9501 GTEx DepMap Descartes 0.00 0.00
INPP4B -0.0003678 10001 GTEx DepMap Descartes 0.03 0.64
P2RX1 -0.0003898 10175 GTEx DepMap Descartes 0.00 0.00
VCL -0.0004203 10424 GTEx DepMap Descartes 0.14 4.30
MCTP1 -0.0004257 10475 GTEx DepMap Descartes 0.01 0.19
GSN -0.0004473 10620 GTEx DepMap Descartes 0.08 2.29
PSTPIP2 -0.0004588 10683 GTEx DepMap Descartes 0.03 0.67
STOM -0.0004840 10840 GTEx DepMap Descartes 0.30 20.81
CD84 -0.0004907 10865 GTEx DepMap Descartes 0.13 1.49
UBASH3B -0.0004933 10876 GTEx DepMap Descartes 0.04 1.25
ZYX -0.0005010 10925 GTEx DepMap Descartes 0.64 73.39
ACTN1 -0.0005513 11201 GTEx DepMap Descartes 0.34 14.07
LIMS1 -0.0005878 11371 GTEx DepMap Descartes 0.86 38.72


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10854.69
Median rank of genes in gene set: 11828
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SCML4 0.0002564 2925 GTEx DepMap Descartes 0.70 40.19
STK39 0.0001147 3852 GTEx DepMap Descartes 0.51 30.75
BCL2 0.0000519 4406 GTEx DepMap Descartes 0.50 15.92
SORL1 -0.0001295 6839 GTEx DepMap Descartes 0.67 15.87
ABLIM1 -0.0001896 7783 GTEx DepMap Descartes 0.38 11.36
EVL -0.0002636 8832 GTEx DepMap Descartes 2.91 186.81
PDE3B -0.0003039 9292 GTEx DepMap Descartes 0.38 19.04
FYN -0.0003607 9943 GTEx DepMap Descartes 2.02 125.23
RAP1GAP2 -0.0003611 9946 GTEx DepMap Descartes 0.16 4.59
ITPKB -0.0003825 10111 GTEx DepMap Descartes 0.04 1.86
FOXP1 -0.0004580 10678 GTEx DepMap Descartes 1.88 48.26
PITPNC1 -0.0004686 10740 GTEx DepMap Descartes 0.19 6.32
TOX -0.0004783 10802 GTEx DepMap Descartes 0.08 4.23
SAMD3 -0.0005269 11062 GTEx DepMap Descartes 0.02 1.74
BACH2 -0.0005449 11159 GTEx DepMap Descartes 0.31 6.95
GNG2 -0.0005808 11337 GTEx DepMap Descartes 0.98 66.12
NCALD -0.0006060 11437 GTEx DepMap Descartes 0.06 2.05
DOCK10 -0.0006159 11475 GTEx DepMap Descartes 0.09 2.30
LEF1 -0.0006740 11678 GTEx DepMap Descartes 0.01 0.19
SKAP1 -0.0006825 11701 GTEx DepMap Descartes 0.03 3.81
MCTP2 -0.0007001 11756 GTEx DepMap Descartes 0.01 0.10
PLEKHA2 -0.0007653 11900 GTEx DepMap Descartes 0.06 2.05
ANKRD44 -0.0007794 11928 GTEx DepMap Descartes 0.23 7.62
CCL5 -0.0008030 11980 GTEx DepMap Descartes 0.72 118.74
PRKCH -0.0008061 11984 GTEx DepMap Descartes 0.02 1.66
ARHGAP15 -0.0008949 12118 GTEx DepMap Descartes 0.04 2.70
ARID5B -0.0009314 12164 GTEx DepMap Descartes 0.05 0.98
IKZF1 -0.0009466 12189 GTEx DepMap Descartes 0.01 0.38
MBNL1 -0.0009694 12216 GTEx DepMap Descartes 0.48 16.74
ETS1 -0.0010608 12296 GTEx DepMap Descartes 0.02 1.03


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.20e-02
Mean rank of genes in gene set: 497
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRDX2 0.0016871 482 GTEx DepMap Descartes 7.57 1065.99
KCNH2 0.0016242 512 GTEx DepMap Descartes 0.83 41.15


pDC: pDC (model markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.66e-02
Mean rank of genes in gene set: 1685.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TRIM71 0.0008019 1213 GTEx DepMap Descartes 0.00 0.00
OGDHL 0.0004318 2158 GTEx DepMap Descartes 0.07 4.51


No detectable expression in this dataset: OR2A25

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.03e-02
Mean rank of genes in gene set: 327
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CKB 0.0021025 327 GTEx DepMap Descartes 4.85 753.49


No detectable expression in this dataset: OR2A25