Program: 2. Fibroblasts.

Program: 2. Fibroblasts.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 VTN 0.0030911 vitronectin GTEx DepMap Descartes 0.20 29.03
2 RANBP3L 0.0030606 RAN binding protein 3 like GTEx DepMap Descartes 0.01 0.04
3 AKAP12 0.0029162 A-kinase anchoring protein 12 GTEx DepMap Descartes 3.41 10.73
4 SLC6A13 0.0028681 solute carrier family 6 member 13 GTEx DepMap Descartes 0.12 1.55
5 COL1A2 0.0028180 collagen type I alpha 2 chain GTEx DepMap Descartes 15.45 118.86
6 SLC22A6 0.0027602 solute carrier family 22 member 6 GTEx DepMap Descartes 0.01 0.38
7 COL1A1 0.0026634 collagen type I alpha 1 chain GTEx DepMap Descartes 13.21 247.54
8 CLDN11 0.0026631 claudin 11 GTEx DepMap Descartes 0.50 13.16
9 COL3A1 0.0026041 collagen type III alpha 1 chain GTEx DepMap Descartes 17.30 130.82
10 LGALS1 0.0025008 galectin 1 GTEx DepMap Descartes 19.91 1598.66
11 IGFBP4 0.0024828 insulin like growth factor binding protein 4 GTEx DepMap Descartes 6.88 163.43
12 SLC7A11 0.0024475 solute carrier family 7 member 11 GTEx DepMap Descartes 0.05 0.03
13 FSTL1 0.0023451 follistatin like 1 GTEx DepMap Descartes 5.54 29.46
14 FBN2 0.0022813 fibrillin 2 GTEx DepMap Descartes 3.77 5.82
15 MFAP2 0.0021122 microfibril associated protein 2 GTEx DepMap Descartes 7.56 434.72
16 ASGR1 0.0020784 asialoglycoprotein receptor 1 GTEx DepMap Descartes 0.01 0.43
17 ISLR 0.0020762 immunoglobulin superfamily containing leucine rich repeat GTEx DepMap Descartes 1.65 10.38
18 COL5A2 0.0020655 collagen type V alpha 2 chain GTEx DepMap Descartes 3.98 8.85
19 COL5A1 0.0019739 collagen type V alpha 1 chain GTEx DepMap Descartes 2.47 4.70
20 IGF2 0.0019726 insulin like growth factor 2 GTEx DepMap Descartes 12.87 237.80
21 FN1 0.0019504 fibronectin 1 GTEx DepMap Descartes 5.06 23.52
22 CDH11 0.0019397 cadherin 11 GTEx DepMap Descartes 2.71 5.11
23 CD248 0.0019281 CD248 molecule GTEx DepMap Descartes 0.97 119.41
24 FOXC1 0.0019275 forkhead box C1 GTEx DepMap Descartes 0.76 44.66
25 CD244 0.0019246 CD244 molecule GTEx DepMap Descartes 0.00 NA
26 A4GALT 0.0018862 alpha 1,4-galactosyltransferase (P blood group) GTEx DepMap Descartes 0.01 0.10
27 FOXD1 0.0018393 forkhead box D1 GTEx DepMap Descartes 1.71 117.15
28 COL12A1 0.0018242 collagen type XII alpha 1 chain GTEx DepMap Descartes 1.95 4.75
29 GPC3 0.0018108 glypican 3 GTEx DepMap Descartes 8.72 7.31
30 BGN 0.0018053 biglycan GTEx DepMap Descartes 3.04 96.42
31 MDK 0.0017953 midkine GTEx DepMap Descartes 19.86 2417.94
32 EVA1B 0.0017932 eva-1 homolog B GTEx DepMap Descartes 1.89 309.26
33 AEBP1 0.0017896 AE binding protein 1 GTEx DepMap Descartes 0.66 24.21
34 COLEC12 0.0017784 collectin subfamily member 12 GTEx DepMap Descartes 1.20 2.13
35 WISP1 0.0017766 NA GTEx DepMap Descartes 0.74 NA
36 CREB3L1 0.0017212 cAMP responsive element binding protein 3 like 1 GTEx DepMap Descartes 0.65 4.30
37 COL6A1 0.0017167 collagen type VI alpha 1 chain GTEx DepMap Descartes 2.29 45.51
38 IFITM1 0.0017146 interferon induced transmembrane protein 1 GTEx DepMap Descartes 0.70 81.80
39 PCOLCE 0.0016908 procollagen C-endopeptidase enhancer GTEx DepMap Descartes 1.73 66.22
40 ATP1A2 0.0016750 ATPase Na+/K+ transporting subunit alpha 2 GTEx DepMap Descartes 0.38 4.62
41 NBL1 0.0016737 NBL1, DAN family BMP antagonist GTEx DepMap Descartes 1.12 39.96
42 SERPINF1 0.0016115 serpin family F member 1 GTEx DepMap Descartes 1.29 33.52
43 COL6A3 0.0016097 collagen type VI alpha 3 chain GTEx DepMap Descartes 1.44 5.64
44 ZFP36L1 0.0015983 ZFP36 ring finger protein like 1 GTEx DepMap Descartes 4.36 205.54
45 CFH 0.0015849 complement factor H GTEx DepMap Descartes 0.20 0.57
46 LOX 0.0015811 lysyl oxidase GTEx DepMap Descartes 0.97 20.93
47 FOXC2 0.0015715 forkhead box C2 GTEx DepMap Descartes 0.61 76.63
48 MEST 0.0015582 mesoderm specific transcript GTEx DepMap Descartes 18.71 217.47
49 PDGFRA 0.0015469 platelet derived growth factor receptor alpha GTEx DepMap Descartes 1.70 12.56
50 ZIC2 0.0015376 Zic family member 2 GTEx DepMap Descartes 0.22 18.25


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UMAP plots showing activity of gene expression program identified in GEP 2. Fibroblasts:

Interactive UMAP Plot
Interactive UMAP Plot
Interactive UMAP Plot
Interactive UMAP Plot
Interactive Boxplot
Interactive Boxplot
Interactive Boxplot
Interactive Boxplot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL 4.19e-28 108.99 55.79 9.38e-26 2.81e-25
18AKAP12, COL1A2, COL1A1, LGALS1, FSTL1, MFAP2, ISLR, COL5A2, COL5A1, COL12A1, GPC3, COL6A1, PCOLCE, SERPINF1, COL6A3, LOX, MEST, PDGFRA
 117
MENON_FETAL_KIDNEY_3_STROMAL_CELLS 1.24e-22 111.92 53.12 1.19e-20 8.30e-20
14AKAP12, COL1A2, COL1A1, CLDN11, COL3A1, LGALS1, FSTL1, COL5A2, IGF2, FN1, CDH11, GPC3, MDK, COL6A3
 81
CUI_DEVELOPING_HEART_SMOOTH_MUSCLE_CELL 3.05e-17 126.37 52.53 1.28e-15 2.05e-14
10COL1A2, COL1A1, COL3A1, IGFBP4, BGN, COLEC12, PCOLCE, SERPINF1, CFH, LOX
 48
DESCARTES_FETAL_THYMUS_STROMAL_CELLS 8.75e-29 99.93 51.74 2.94e-26 5.87e-26
19COL1A2, COL1A1, COL3A1, FSTL1, FBN2, ISLR, COL5A2, COL5A1, IGF2, CD248, COL12A1, GPC3, BGN, CREB3L1, COL6A1, PCOLCE, LOX, MEST, PDGFRA
 137
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS 1.58e-20 97.87 45.70 8.82e-19 1.06e-17
13AKAP12, COL1A2, COL1A1, CLDN11, COL3A1, LGALS1, IGFBP4, CDH11, BGN, AEBP1, PCOLCE, NBL1, SERPINF1
 82
DESCARTES_FETAL_EYE_STROMAL_CELLS 5.70e-20 87.76 41.18 2.73e-18 3.82e-17
13COL1A2, COL1A1, COL3A1, ISLR, COL5A2, COL5A1, FN1, COL12A1, CREB3L1, COL6A1, PCOLCE, COL6A3, LOX
 90
DESCARTES_FETAL_HEART_STROMAL_CELLS 2.52e-12 115.63 40.35 6.77e-11 1.69e-09
7COL1A2, COL1A1, ISLR, GPC3, PCOLCE, SERPINF1, PDGFRA
 34
CUI_DEVELOPING_HEART_COMPACT_VENTRICULAR_CARDIOMYOCYTE 8.01e-16 87.47 37.09 2.99e-14 5.38e-13
10COL1A2, COL1A1, COL3A1, LGALS1, COL5A2, COL5A1, FN1, COL12A1, COL6A1, COL6A3
 65
HU_FETAL_RETINA_FIBROBLAST 6.87e-30 53.55 29.18 4.61e-27 4.61e-27
25COL1A2, COL1A1, COL3A1, LGALS1, IGFBP4, FSTL1, FBN2, MFAP2, COL5A2, COL5A1, IGF2, FN1, CDH11, CD248, FOXC1, BGN, MDK, EVA1B, AEBP1, PCOLCE, COL6A3, ZFP36L1, FOXC2, MEST, PDGFRA
 385
AIZARANI_LIVER_C21_STELLATE_CELLS_1 3.26e-22 56.03 28.75 2.73e-20 2.19e-19
17COL1A2, COL1A1, CLDN11, COL3A1, LGALS1, IGFBP4, FSTL1, COL5A1, BGN, AEBP1, COL6A1, PCOLCE, SERPINF1, COL6A3, ZFP36L1, CFH, PDGFRA
 194
GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR 1.08e-15 61.70 27.60 3.80e-14 7.22e-13
11COL1A2, COL1A1, CLDN11, COL3A1, ISLR, COL5A2, COL5A1, COLEC12, PCOLCE, SERPINF1, LOX
 99
FAN_OVARY_CL6_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_2 1.65e-25 50.09 26.76 2.77e-23 1.11e-22
21AKAP12, COL1A2, COL1A1, CLDN11, COL3A1, LGALS1, IGFBP4, FSTL1, FN1, CDH11, GPC3, BGN, MDK, AEBP1, COL6A1, NBL1, SERPINF1, COL6A3, ZFP36L1, CFH, PDGFRA
 300
DESCARTES_MAIN_FETAL_STROMAL_CELLS 1.85e-07 104.10 24.46 3.89e-06 1.24e-04
4COL1A2, COL1A1, COL5A1, COL12A1
 20
TRAVAGLINI_LUNG_ADVENTITIAL_FIBROBLAST_CELL 1.14e-20 39.00 20.35 6.93e-19 7.63e-18
18AKAP12, COL1A2, COL1A1, CLDN11, COL3A1, IGFBP4, FSTL1, ISLR, CD248, COLEC12, COL6A1, IFITM1, PCOLCE, SERPINF1, COL6A3, CFH, LOX, PDGFRA
 296
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2 1.72e-20 38.04 19.85 8.89e-19 1.16e-17
18AKAP12, COL1A2, COL3A1, LGALS1, FSTL1, COL5A2, FN1, CDH11, CD248, BGN, MDK, AEBP1, COLEC12, COL6A1, IFITM1, PCOLCE, ATP1A2, CFH
 303
FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL 3.86e-22 37.25 19.83 2.88e-20 2.59e-19
20COL1A2, COL3A1, LGALS1, IGFBP4, FSTL1, MFAP2, COL5A2, FN1, CDH11, CD248, FOXC1, BGN, EVA1B, AEBP1, COLEC12, COL6A1, IFITM1, PCOLCE, ATP1A2, ZIC2
 365
RUBENSTEIN_SKELETAL_MUSCLE_FAP_CELLS 5.56e-16 40.73 19.53 2.19e-14 3.73e-13
13AKAP12, COL1A2, COL1A1, COL3A1, FSTL1, ISLR, FN1, COL6A1, PCOLCE, SERPINF1, COL6A3, CFH, PDGFRA
 179
DESCARTES_FETAL_ADRENAL_STROMAL_CELLS 1.40e-13 38.28 17.31 4.08e-12 9.39e-11
11COL1A1, CLDN11, COL3A1, ISLR, CDH11, CD248, COL12A1, PCOLCE, COL6A3, LOX, PDGFRA
 153
MURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL 7.06e-24 29.44 16.14 9.47e-22 4.74e-21
25AKAP12, COL1A2, COL1A1, COL3A1, LGALS1, IGFBP4, SLC7A11, FSTL1, ISLR, COL5A2, COL5A1, FN1, CDH11, CD248, COL12A1, BGN, AEBP1, CREB3L1, COL6A1, IFITM1, SERPINF1, COL6A3, ZFP36L1, LOX, PDGFRA
 680
FAN_OVARY_CL2_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_1 1.41e-10 40.75 16.06 3.65e-09 9.49e-08
8COL1A2, COL1A1, LGALS1, MDK, COL6A1, NBL1, SERPINF1, ZFP36L1
 98

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 9.56e-24 59.47 30.84 4.78e-22 4.78e-22
18COL1A2, COL1A1, COL3A1, LGALS1, IGFBP4, FSTL1, FBN2, COL5A2, COL5A1, FN1, CDH11, COL12A1, BGN, PCOLCE, COL6A3, LOX, FOXC2, MEST
 200
HALLMARK_ANGIOGENESIS 2.18e-06 52.24 12.92 5.45e-05 1.09e-04
4VTN, COL3A1, FSTL1, COL5A2
 36
HALLMARK_HYPOXIA 1.56e-04 10.98 3.37 1.95e-03 7.81e-03
5AKAP12, COL5A1, GPC3, BGN, LOX
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.56e-04 10.98 3.37 1.95e-03 7.81e-03
5IGFBP4, FOXC1, MDK, NBL1, MEST
 200
HALLMARK_UV_RESPONSE_DN 5.07e-04 11.97 3.09 5.07e-03 2.54e-02
4COL1A2, COL1A1, COL3A1, COL5A2
 144
HALLMARK_MYOGENESIS 1.70e-03 8.55 2.21 1.42e-02 8.51e-02
4COL1A1, COL3A1, AEBP1, COL6A3
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.46e-02 6.25 1.23 8.10e-02 7.29e-01
3IGFBP4, FOXC1, NBL1
 200
HALLMARK_APICAL_JUNCTION 1.46e-02 6.25 1.23 8.10e-02 7.29e-01
3CLDN11, CDH11, MDK
 200
HALLMARK_KRAS_SIGNALING_UP 1.46e-02 6.25 1.23 8.10e-02 7.29e-01
3AKAP12, IGF2, CFH
 200
HALLMARK_COAGULATION 4.90e-02 5.91 0.69 2.45e-01 1.00e+00
2FN1, CFH
 138
HALLMARK_COMPLEMENT 9.29e-02 4.06 0.47 3.10e-01 1.00e+00
2FN1, CFH
 200
HALLMARK_INFLAMMATORY_RESPONSE 9.29e-02 4.06 0.47 3.10e-01 1.00e+00
2GPC3, IFITM1
 200
HALLMARK_XENOBIOTIC_METABOLISM 9.29e-02 4.06 0.47 3.10e-01 1.00e+00
2VTN, IGFBP4
 200
HALLMARK_GLYCOLYSIS 9.29e-02 4.06 0.47 3.10e-01 1.00e+00
2COL5A1, GPC3
 200
HALLMARK_P53_PATHWAY 9.29e-02 4.06 0.47 3.10e-01 1.00e+00
2SLC7A11, ZFP36L1
 200
HALLMARK_INTERFERON_ALPHA_RESPONSE 2.22e-01 4.10 0.10 6.70e-01 1.00e+00
1IFITM1
 97
HALLMARK_ANDROGEN_RESPONSE 2.28e-01 3.97 0.10 6.70e-01 1.00e+00
1AKAP12
 100
HALLMARK_FATTY_ACID_METABOLISM 3.35e-01 2.51 0.06 8.75e-01 1.00e+00
1LGALS1
 158
HALLMARK_APOPTOSIS 3.40e-01 2.46 0.06 8.75e-01 1.00e+00
1BGN
 161
HALLMARK_IL2_STAT5_SIGNALING 4.01e-01 1.99 0.05 8.75e-01 1.00e+00
1COL6A1
 199

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_ECM_RECEPTOR_INTERACTION 7.42e-13 56.30 23.24 1.38e-10 1.38e-10
9VTN, COL1A2, COL1A1, COL3A1, COL5A2, COL5A1, FN1, COL6A1, COL6A3
 84
KEGG_FOCAL_ADHESION 6.94e-11 25.49 11.20 6.45e-09 1.29e-08
10VTN, COL1A2, COL1A1, COL3A1, COL5A2, COL5A1, FN1, COL6A1, COL6A3, PDGFRA
 199
KEGG_PROSTATE_CANCER 2.21e-02 9.23 1.07 1.00e+00 1.00e+00
2CREB3L1, PDGFRA
 89
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES 3.56e-02 30.23 0.70 1.00e+00 1.00e+00
1A4GALT
 14
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 1.03e-01 3.81 0.45 1.00e+00 1.00e+00
2FN1, PDGFRA
 213
KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 5.78e-02 17.87 0.42 1.00e+00 1.00e+00
1ATP1A2
 23
KEGG_PATHWAYS_IN_CANCER 2.00e-01 2.49 0.29 1.00e+00 1.00e+00
2FN1, PDGFRA
 325
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 1.03e-01 9.59 0.23 1.00e+00 1.00e+00
1ATP1A2
 42
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.08e-01 9.15 0.22 1.00e+00 1.00e+00
1CREB3L1
 44
KEGG_HEDGEHOG_SIGNALING_PATHWAY 1.35e-01 7.15 0.17 1.00e+00 1.00e+00
1ZIC2
 56
KEGG_GLIOMA 1.55e-01 6.15 0.15 1.00e+00 1.00e+00
1PDGFRA
 65
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 1.63e-01 5.78 0.14 1.00e+00 1.00e+00
1CFH
 69
KEGG_MELANOMA 1.68e-01 5.62 0.14 1.00e+00 1.00e+00
1PDGFRA
 71
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 1.76e-01 5.32 0.13 1.00e+00 1.00e+00
1IFITM1
 75
KEGG_CARDIAC_MUSCLE_CONTRACTION 1.85e-01 5.04 0.12 1.00e+00 1.00e+00
1ATP1A2
 79
KEGG_SMALL_CELL_LUNG_CANCER 1.95e-01 4.74 0.12 1.00e+00 1.00e+00
1FN1
 84
KEGG_GAP_JUNCTION 2.08e-01 4.42 0.11 1.00e+00 1.00e+00
1PDGFRA
 90
KEGG_MELANOGENESIS 2.30e-01 3.93 0.10 1.00e+00 1.00e+00
1CREB3L1
 101
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 2.59e-01 3.42 0.08 1.00e+00 1.00e+00
1CLDN11
 116
KEGG_TIGHT_JUNCTION 2.89e-01 3.00 0.07 1.00e+00 1.00e+00
1CLDN11
 132

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2q32 3.15e-02 7.58 0.88 1.00e+00 1.00e+00
2COL3A1, COL5A2
 108
chr5q23 3.31e-02 7.37 0.86 1.00e+00 1.00e+00
2FBN2, LOX
 111
chr11p11 5.35e-02 5.62 0.66 1.00e+00 1.00e+00
2MDK, CREB3L1
 145
chr1q23 1.06e-01 3.74 0.44 1.00e+00 1.00e+00
2CD244, ATP1A2
 217
chr22q13 1.82e-01 2.65 0.31 1.00e+00 1.00e+00
2LGALS1, A4GALT
 305
chr17p13 2.10e-01 2.41 0.28 1.00e+00 1.00e+00
2ASGR1, SERPINF1
 336
chr17q21 3.22e-01 1.77 0.21 1.00e+00 1.00e+00
2COL1A1, IGFBP4
 457
chr7p13 1.21e-01 8.03 0.20 1.00e+00 1.00e+00
1AEBP1
 50
chr1p36 6.80e-01 1.23 0.14 1.00e+00 1.00e+00
2MFAP2, NBL1
 656
chr1q31 1.68e-01 5.62 0.14 1.00e+00 1.00e+00
1CFH
 71
chr16q21 1.74e-01 5.39 0.13 1.00e+00 1.00e+00
1CDH11
 74
chr4q12 1.85e-01 5.04 0.12 1.00e+00 1.00e+00
1PDGFRA
 79
chr6p25 1.91e-01 4.86 0.12 1.00e+00 1.00e+00
1FOXC1
 82
chr7q32 2.08e-01 4.42 0.11 1.00e+00 1.00e+00
1MEST
 90
chr6q14 2.14e-01 4.28 0.11 1.00e+00 1.00e+00
1COL12A1
 93
chr13q32 2.18e-01 4.19 0.10 1.00e+00 1.00e+00
1ZIC2
 95
chr15q24 2.59e-01 3.42 0.08 1.00e+00 1.00e+00
1ISLR
 116
chr2q35 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1FN1
 126
chr5p13 2.81e-01 3.10 0.08 1.00e+00 1.00e+00
1RANBP3L
 128
chr16q24 2.85e-01 3.05 0.08 1.00e+00 1.00e+00
1FOXC2
 130

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
CTTTAAR_UNKNOWN 1.29e-04 4.90 2.18 1.46e-01 1.46e-01
10SLC6A13, CLDN11, CREB3L1, ATP1A2, NBL1, SERPINF1, COL6A3, ZFP36L1, PDGFRA, ZIC2
 994
OCT1_02 2.17e-03 7.98 2.07 4.60e-01 1.00e+00
4GPC3, CREB3L1, LOX, ZIC2
 214
PBX1_02 4.74e-03 9.54 1.87 4.60e-01 1.00e+00
3AKAP12, IGF2, ZFP36L1
 132
OCT1_03 3.08e-03 7.23 1.87 4.60e-01 1.00e+00
4SLC7A11, GPC3, ZFP36L1, PDGFRA
 236
SRF_Q6 3.67e-03 6.87 1.78 4.60e-01 1.00e+00
4COL1A2, COL1A1, CD248, ATP1A2
 248
TFIIA_Q6 4.10e-03 6.65 1.73 4.60e-01 1.00e+00
4COL1A1, CD248, GPC3, ZIC2
 256
STAT_01 4.21e-03 6.60 1.71 4.60e-01 1.00e+00
4VTN, FN1, PCOLCE, ZFP36L1
 258
CP2_01 4.33e-03 6.55 1.70 4.60e-01 1.00e+00
4COL1A2, COL1A1, GPC3, ZIC2
 260
CEBPB_02 4.69e-03 6.40 1.66 4.60e-01 1.00e+00
4SLC7A11, ASGR1, SERPINF1, PDGFRA
 266
DR4_Q2 4.69e-03 6.40 1.66 4.60e-01 1.00e+00
4COL1A2, CD248, ATP1A2, ZIC2
 266
EGR1_01 4.87e-03 6.33 1.64 4.60e-01 1.00e+00
4VTN, AKAP12, CREB3L1, PCOLCE
 269
TTGCWCAAY_CEBPB_02 1.15e-02 13.16 1.52 7.08e-01 1.00e+00
2SLC7A11, ZFP36L1
 63
TGGAAA_NFAT_Q4_01 1.43e-03 3.17 1.51 4.60e-01 1.00e+00
12RANBP3L, COL1A2, LGALS1, FSTL1, FN1, COL12A1, COLEC12, ATP1A2, ZFP36L1, LOX, PDGFRA, ZIC2
 1934
HTF_01 1.44e-02 11.64 1.34 7.08e-01 1.00e+00
2COL1A2, CREB3L1
 71
TGANTCA_AP1_C 5.99e-03 3.25 1.31 5.22e-01 1.00e+00
8COL1A1, LGALS1, COL5A2, CD244, GPC3, AEBP1, ZFP36L1, PDGFRA
 1139
AAANWWTGC_UNKNOWN 1.36e-02 6.41 1.27 7.08e-01 1.00e+00
3FN1, GPC3, LOX
 195
EGR2_01 1.42e-02 6.31 1.25 7.08e-01 1.00e+00
3VTN, COLEC12, PCOLCE
 198
GR_01 1.52e-02 6.15 1.21 7.08e-01 1.00e+00
3SLC7A11, LOX, ZIC2
 203
AAAYRNCTG_UNKNOWN 1.49e-02 4.52 1.18 7.08e-01 1.00e+00
4COL1A2, COL12A1, ATP1A2, PDGFRA
 375
RP58_01 1.70e-02 5.89 1.16 7.08e-01 1.00e+00
3COL3A1, COLEC12, PCOLCE
 212

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_COLLAGEN_FIBRIL_ORGANIZATION 1.10e-16 108.95 45.77 4.11e-13 8.23e-13
10COL1A2, COL1A1, COL3A1, COL5A2, COL5A1, FOXC1, COL12A1, AEBP1, LOX, FOXC2
 54
GOBP_ENDODERMAL_CELL_DIFFERENTIATION 1.42e-09 69.14 22.69 9.66e-07 1.06e-05
6VTN, COL5A2, COL5A1, FN1, COL12A1, COL6A1
 44
GOBP_APOPTOTIC_PROCESS_INVOLVED_IN_HEART_MORPHOGENESIS 6.52e-05 265.22 21.74 8.41e-03 4.88e-01
2FOXC1, FOXC2
 5
GOBP_REGULATION_OF_ENDODERMAL_CELL_DIFFERENTIATION 6.52e-05 265.22 21.74 8.41e-03 4.88e-01
2COL5A2, COL5A1
 5
GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT 6.52e-05 265.22 21.74 8.41e-03 4.88e-01
2FOXC1, FOXC2
 5
GOBP_ENDODERM_FORMATION 4.52e-09 55.84 18.55 2.12e-06 3.38e-05
6VTN, COL5A2, COL5A1, FN1, COL12A1, COL6A1
 53
GOBP_ENDODERM_DEVELOPMENT 9.30e-10 45.48 16.65 6.96e-07 6.96e-06
7VTN, COL5A2, COL5A1, FN1, COL12A1, COL6A1, ZFP36L1
 76
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION 6.31e-20 31.35 16.57 4.72e-16 4.72e-16
19VTN, COL1A2, COL1A1, COL3A1, FBN2, MFAP2, COL5A2, COL5A1, FN1, FOXC1, COL12A1, BGN, AEBP1, CREB3L1, COL6A1, COL6A3, LOX, FOXC2, PDGFRA
 396
GOBP_PARAXIAL_MESODERM_FORMATION 1.36e-04 159.06 14.87 1.39e-02 1.00e+00
2FOXC1, FOXC2
 7
GOBP_MAINTENANCE_OF_PROTEIN_LOCATION_IN_EXTRACELLULAR_REGION 1.36e-04 159.06 14.87 1.39e-02 1.00e+00
2FBN2, NBL1
 7
GOBP_FORMATION_OF_PRIMARY_GERM_LAYER 5.11e-10 34.29 13.58 4.78e-07 3.82e-06
8VTN, COL5A2, COL5A1, FN1, FOXC1, COL12A1, COL6A1, FOXC2
 115
GOBP_BONE_TRABECULA_FORMATION 2.33e-04 114.17 11.31 2.10e-02 1.00e+00
2COL1A1, FBN2
 9
GOBP_OSSIFICATION 3.53e-14 21.53 10.83 8.79e-11 2.64e-10
15RANBP3L, COL1A2, COL1A1, FBN2, COL5A2, IGF2, CDH11, FOXC1, GPC3, MDK, CREB3L1, COL6A1, IFITM1, LOX, FOXC2
 399
GOBP_GASTRULATION 6.83e-10 24.88 10.46 5.68e-07 5.11e-06
9VTN, COL5A2, COL5A1, FN1, FOXC1, COL12A1, GPC3, COL6A1, FOXC2
 179
GOBP_SEQUESTERING_OF_EXTRACELLULAR_LIGAND_FROM_RECEPTOR 2.91e-04 100.19 10.10 2.37e-02 1.00e+00
2FBN2, NBL1
 10
GOBP_PARAXIAL_MESODERM_MORPHOGENESIS 2.91e-04 100.19 10.10 2.37e-02 1.00e+00
2FOXC1, FOXC2
 10
GOBP_CELLULAR_RESPONSE_TO_ACID_CHEMICAL 9.20e-07 33.43 10.03 2.46e-04 6.88e-03
5COL1A2, COL1A1, COL5A2, COL6A1, PDGFRA
 69
GOBP_SKIN_MORPHOGENESIS 3.55e-04 88.95 9.12 2.71e-02 1.00e+00
2COL1A2, COL1A1
 11
GOBP_REGULATION_OF_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT 3.55e-04 88.95 9.12 2.71e-02 1.00e+00
2FOXC1, FOXC2
 11
GOBP_BONE_TRABECULA_MORPHOGENESIS 4.25e-04 79.97 8.32 3.15e-02 1.00e+00
2COL1A1, FBN2
 12

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE4748_CTRL_VS_LPS_STIM_DC_3H_UP 3.91e-08 19.12 7.65 1.90e-04 1.90e-04
8AKAP12, COL3A1, FSTL1, COL5A2, CDH11, CD248, CREB3L1, PDGFRA
 200
GSE3039_CD4_TCELL_VS_B2_BCELL_UP 1.17e-05 13.54 4.66 1.42e-02 5.69e-02
6IGFBP4, FSTL1, FN1, CDH11, BGN, CFH
 200
GSE22935_WT_VS_MYD88_KO_MACROPHAGE_48H_MBOVIS_BCG_STIM_DN 1.17e-05 13.54 4.66 1.42e-02 5.69e-02
6COL3A1, LGALS1, SLC7A11, FSTL1, CD244, AEBP1
 200
GSE28737_BCL6_HET_VS_BCL6_KO_FOLLICULAR_BCELL_DN 1.17e-05 13.54 4.66 1.42e-02 5.69e-02
6COL1A2, COL1A1, FSTL1, BGN, COL6A3, LOX
 200
GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_DN 7.33e-05 12.98 3.97 7.14e-02 3.57e-01
5COL1A1, FSTL1, COL5A2, GPC3, ZFP36L1
 170
GSE17721_0.5H_VS_24H_CPG_BMDC_DN 1.56e-04 10.98 3.37 8.45e-02 7.61e-01
5SLC6A13, IGFBP4, FSTL1, COL5A1, LOX
 200
GSE9650_GP33_VS_GP276_LCMV_SPECIFIC_EXHAUSTED_CD8_TCELL_UP 1.56e-04 10.98 3.37 8.45e-02 7.61e-01
5CLDN11, FSTL1, IGF2, CFH, PDGFRA
 200
GSE8835_HEALTHY_VS_CLL_CD8_TCELL_DN 1.56e-04 10.98 3.37 8.45e-02 7.61e-01
5COL1A2, COL1A1, COL3A1, COL5A1, ZFP36L1
 200
GSE37301_RAG2_KO_VS_RAG2_AND_ETS1_KO_NK_CELL_UP 1.56e-04 10.98 3.37 8.45e-02 7.61e-01
5COL1A1, GPC3, COL6A1, ZFP36L1, CFH
 200
GSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP 8.42e-04 10.41 2.69 2.30e-01 1.00e+00
4LGALS1, ISLR, IGF2, COL12A1
 165
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP 1.33e-03 9.16 2.37 2.30e-01 1.00e+00
4FSTL1, COLEC12, PCOLCE, SERPINF1
 187
GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_2H_ACT_CD4_TCELL_DN 1.39e-03 9.06 2.34 2.30e-01 1.00e+00
4FSTL1, GPC3, COLEC12, COL6A3
 189
GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_UP 1.55e-03 8.78 2.27 2.30e-01 1.00e+00
4COL5A2, CD248, AEBP1, MEST
 195
GSE11057_NAIVE_VS_CENT_MEMORY_CD4_TCELL_UP 1.58e-03 8.73 2.26 2.30e-01 1.00e+00
4COL5A2, CD248, AEBP1, MEST
 196
GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_BCELL_UP 1.58e-03 8.73 2.26 2.30e-01 1.00e+00
4IGFBP4, ISLR, BGN, CFH
 196
GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN 1.61e-03 8.68 2.25 2.30e-01 1.00e+00
4COL6A1, IFITM1, ZFP36L1, LOX
 197
GSE360_DC_VS_MAC_T_GONDII_UP 1.64e-03 8.64 2.24 2.30e-01 1.00e+00
4FN1, CDH11, PCOLCE, ATP1A2
 198
GSE360_T_GONDII_VS_M_TUBERCULOSIS_MAC_DN 1.64e-03 8.64 2.24 2.30e-01 1.00e+00
4FSTL1, CDH11, CREB3L1, IFITM1
 198
GSE17186_MEMORY_VS_CD21HIGH_TRANSITIONAL_BCELL_UP 1.64e-03 8.64 2.24 2.30e-01 1.00e+00
4SLC7A11, A4GALT, NBL1, ZFP36L1
 198
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_DP_THYMOCYTES_UP 1.64e-03 8.64 2.24 2.30e-01 1.00e+00
4FSTL1, FN1, FOXC1, IFITM1
 198

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
FOXC1 24 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FOXD1 27 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
AEBP1 33 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).
CREB3L1 36 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZFP36L1 44 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 27102483; PMID: 17013884).
FOXC2 47 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZIC2 50 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
TWIST1 54 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Can form both homodimers and heterodimers with TCF3 (PMID: 16502419).
EGR1 56 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
OSR1 69 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CYP1B1 70 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
FOS 107 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HIC1 109 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PRRX1 111 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
BTG2 116 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-factor (PMID: 10617598)
ZIC4 120 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
JUND 144 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FBN1 155 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PRDM6 161 Yes Known motif Monomer or homomultimer In vivo/Misc source Motif obtained from MEME - not supported by recognition code (RCADE) and may be inaccurate or indirect None
ID3 165 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
X71_AACCAACGTCACCCTT iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.41 1444.91
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.63, Neuroepithelial_cell:ESC-derived: 0.62, Neurons:ES_cell-derived_neural_precursor: 0.61, Astrocyte:Embryonic_stem_cell-derived: 0.6, Embryonic_stem_cells: 0.6, Fibroblasts:breast: 0.6, Keratinocytes: 0.6, Keratinocytes:IL26: 0.6, iPS_cells:adipose_stem_cells: 0.59, Keratinocytes:KGF: 0.57
X71_GCTACAACACAATGAA Neuroepithelial_cell:ESC-derived 0.33 1102.14
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X71_TAACCAGTCCCAGGAC Keratinocytes:KGF 0.48 1031.00
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X72_GGTGTCGTCCTCACCA Neurons:ES_cell-derived_neural_precursor 0.33 988.85
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.64, Chondrocytes:MSC-derived: 0.63, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.57, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.55
X71_CAGATACGTGGCATCC Neuroepithelial_cell:ESC-derived 0.35 988.57
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_TGTTACTGTCTAACGT Neuroepithelial_cell:ESC-derived 0.38 928.45
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.75, Neurons:ES_cell-derived_neural_precursor: 0.75, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.73, Embryonic_stem_cells: 0.72, Fibroblasts:breast: 0.68, Keratinocytes: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.68, Astrocyte:Embryonic_stem_cell-derived: 0.67
X72_TCTATCATCCTGTTAT Neuroepithelial_cell:ESC-derived 0.40 909.16
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X72_ACACAGTTCCTACTGC Chondrocytes:MSC-derived 0.31 902.86
Raw ScoresChondrocytes:MSC-derived: 0.72, MSC: 0.66, iPS_cells:adipose_stem_cells: 0.66, Osteoblasts: 0.65, Smooth_muscle_cells:bronchial: 0.64, Smooth_muscle_cells:bronchial:vit_D: 0.64, Fibroblasts:breast: 0.63, Neuroepithelial_cell:ESC-derived: 0.62, Neurons:ES_cell-derived_neural_precursor: 0.62, Osteoblasts:BMP2: 0.61
X72_CGAGTTACACAGACGA Neurons:ES_cell-derived_neural_precursor 0.33 902.30
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.64, Chondrocytes:MSC-derived: 0.63, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.57, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.55
X71_CGGCAGTAGGCTTTCA Neuroepithelial_cell:ESC-derived 0.40 899.22
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X71_GAAGCCCCAGCTTCGG Neuroepithelial_cell:ESC-derived 0.37 897.07
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.75, Embryonic_stem_cells: 0.73, MSC: 0.73, Keratinocytes: 0.69, Keratinocytes:IL26: 0.69, Fibroblasts:breast: 0.69, iPS_cells:adipose_stem_cells: 0.69, Keratinocytes:KGF: 0.67
X71_AGTCTCCCACACAGCC Neuroepithelial_cell:ESC-derived 0.33 862.80
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X71_TGGGAAGCACAAGCTT Neurons:ES_cell-derived_neural_precursor 0.40 859.66
Raw ScoresNeurons:ES_cell-derived_neural_precursor: 0.68, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.68, Neuroepithelial_cell:ESC-derived: 0.65, Embryonic_stem_cells: 0.65, Keratinocytes:KGF: 0.64, iPS_cells:adipose_stem_cells: 0.64, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.64, Keratinocytes:IL26: 0.63, Fibroblasts:breast: 0.63, Keratinocytes: 0.63
X71_GTATTGGCAAATGCGG Neuroepithelial_cell:ESC-derived 0.33 845.18
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.58, Embryonic_stem_cells: 0.57, Neurons:adrenal_medulla_cell_line: 0.55
X72_TCGTAGATCTGACGCG Neuroepithelial_cell:ESC-derived 0.35 821.21
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_CGGGACTCAGAACCGA Neuroepithelial_cell:ESC-derived 0.38 797.36
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.75, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.74, Embryonic_stem_cells: 0.72, Fibroblasts:breast: 0.68, Keratinocytes: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.67, Astrocyte:Embryonic_stem_cell-derived: 0.66
X71_AGGAATATCGCACTCT Neuroepithelial_cell:ESC-derived 0.35 790.66
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_ATGCATGAGATTGCGG Neuroepithelial_cell:ESC-derived 0.35 770.50
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_CTGTCGTAGGCCATAG Neurons:ES_cell-derived_neural_precursor 0.33 735.27
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.64, Chondrocytes:MSC-derived: 0.63, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.57, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.55
X71_ACAAAGAGTACCGTCG Keratinocytes:KGF 0.48 733.08
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X71_CTGCATCCACCATAAC Neuroepithelial_cell:ESC-derived 0.33 732.13
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.58, Embryonic_stem_cells: 0.57, Neurons:adrenal_medulla_cell_line: 0.55
X71_TCTATCAAGCACTCGC Neuroepithelial_cell:ESC-derived 0.33 729.67
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X72_GTCTTTAGTGGCACTC Neuroepithelial_cell:ESC-derived 0.32 726.28
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.71, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.67, Keratinocytes:IL26: 0.65, Keratinocytes: 0.65, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.64, Embryonic_stem_cells: 0.64, Chondrocytes:MSC-derived: 0.63, Keratinocytes:IL20: 0.63, Keratinocytes:IFNg: 0.62
X72_GGCGTCAAGAGGTTTA Keratinocytes:KGF 0.46 724.54
Raw ScoresKeratinocytes:KGF: 0.58, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.58, iPS_cells:adipose_stem_cells: 0.58, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.57, Keratinocytes: 0.57, Keratinocytes:IFNg: 0.57, Keratinocytes:IL19: 0.57, Keratinocytes:IL1b: 0.57, Keratinocytes:IL20: 0.57, Keratinocytes:IL22: 0.57
X71_CAACCTCTCCGTAGGC Neuroepithelial_cell:ESC-derived 0.40 722.14
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X72_ATCGTAGGTTGCCGAC Neuroepithelial_cell:ESC-derived 0.35 718.21
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_AGGGAGTAGATCGGTG iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.41 715.50
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.64, Astrocyte:Embryonic_stem_cell-derived: 0.62, Fibroblasts:breast: 0.62, Keratinocytes: 0.62, Keratinocytes:IL26: 0.62, Neuroepithelial_cell:ESC-derived: 0.61, Neurons:ES_cell-derived_neural_precursor: 0.61, Embryonic_stem_cells: 0.61, iPS_cells:adipose_stem_cells: 0.61, Keratinocytes:KGF: 0.59
X71_TTTGTTGCAGGATGAC Neuroepithelial_cell:ESC-derived 0.35 707.56
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_CGCCAGACAGGCCTGT Neuroepithelial_cell:ESC-derived 0.40 707.56
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X71_TTTAGTCAGATTAGAC Keratinocytes:KGF 0.48 661.66
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X71_CATTCATGTTTGAACC iPS_cells:adipose_stem_cells 0.43 658.73
Raw ScoresiPS_cells:adipose_stem_cells: 0.76, Fibroblasts:breast: 0.76, Chondrocytes:MSC-derived: 0.67, Tissue_stem_cells:BM_MSC:TGFb3: 0.65, Neurons:ES_cell-derived_neural_precursor: 0.64, Smooth_muscle_cells:vascular: 0.64, MSC: 0.63, Smooth_muscle_cells:vascular:IL-17: 0.62, Keratinocytes:KGF: 0.6, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.6
X71_CACAACATCCGCTTAC Neuroepithelial_cell:ESC-derived 0.33 653.90
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X72_CTCAACCTCAGTCCGG Neuroepithelial_cell:ESC-derived 0.33 647.10
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X71_AAGATAGAGAACTCCT Neuroepithelial_cell:ESC-derived 0.40 638.21
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X71_CAAGAGGCAAGCCATT Neuroepithelial_cell:ESC-derived 0.35 636.64
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_GACTCAAGTCTGTGCG Neuroepithelial_cell:ESC-derived 0.37 599.71
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.75, Embryonic_stem_cells: 0.73, MSC: 0.73, Keratinocytes: 0.69, Keratinocytes:IL26: 0.69, Fibroblasts:breast: 0.69, iPS_cells:adipose_stem_cells: 0.69, Keratinocytes:KGF: 0.67
X72_AAGGAATGTTTCACAG Keratinocytes:KGF 0.48 590.53
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X71_CACAGATAGGTGCTTT Neuroepithelial_cell:ESC-derived 0.35 583.00
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_CTATCCGGTTCTATCT Neurons:ES_cell-derived_neural_precursor 0.33 582.71
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.64, Chondrocytes:MSC-derived: 0.63, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.57, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.55
X71_TCATTACCATGAGAAT Neuroepithelial_cell:ESC-derived 0.35 574.15
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_CGCATAAAGGATTACA Neuroepithelial_cell:ESC-derived 0.35 570.96
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_ACGTACATCTGCATGA Neuroepithelial_cell:ESC-derived 0.35 567.83
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_GCGGAAATCGGCATAT Keratinocytes:KGF 0.48 563.63
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X70_CCTCATGCAGCTATAC Neuroepithelial_cell:ESC-derived 0.27 562.44
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.61, Neurons:ES_cell-derived_neural_precursor: 0.59, Erythroblast: 0.56, Gametocytes:oocyte: 0.56, Chondrocytes:MSC-derived: 0.56, MSC: 0.55, DC:monocyte-derived:immature: 0.54, iPS_cells:PDB_2lox-17: 0.5, Smooth_muscle_cells:bronchial: 0.48, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.48
X71_TGTAACGGTTAACCTG Neuroepithelial_cell:ESC-derived 0.35 553.08
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_ACAAAGAAGACGTCGA Neuroepithelial_cell:ESC-derived 0.33 551.62
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.58, Embryonic_stem_cells: 0.57, Neurons:adrenal_medulla_cell_line: 0.55
X72_ATCGTCCCAAGCAGGT Neuroepithelial_cell:ESC-derived 0.33 542.20
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.69, Neurons:ES_cell-derived_neural_precursor: 0.66, MSC: 0.65, Keratinocytes:IL26: 0.64, Keratinocytes: 0.64, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.62, Astrocyte:Embryonic_stem_cell-derived: 0.62, Embryonic_stem_cells: 0.61, Keratinocytes:IFNg: 0.61, Keratinocytes:IL20: 0.61
X71_GTGGAGAAGACATACA Keratinocytes:KGF 0.48 542.16
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X71_TCCCAGTCATTGGCAT iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.42 540.61
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.81, Embryonic_stem_cells: 0.78, Neuroepithelial_cell:ESC-derived: 0.75, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.73, Gametocytes:oocyte: 0.71, iPS_cells:fibroblast-derived:Retroviral_transf: 0.71, Astrocyte:Embryonic_stem_cell-derived: 0.69, Keratinocytes:IL26: 0.69, MSC: 0.68, Keratinocytes:KGF: 0.67
X71_TTGTTGTGTACGATCT Neuroepithelial_cell:ESC-derived 0.35 536.60
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.64e-11
Mean rank of genes in gene set: 4383.76
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A2 0.0028180 5 GTEx DepMap Descartes 15.45 118.86
COL1A1 0.0026634 7 GTEx DepMap Descartes 13.21 247.54
COL3A1 0.0026041 9 GTEx DepMap Descartes 17.30 130.82
COL5A2 0.0020655 18 GTEx DepMap Descartes 3.98 8.85
COL5A1 0.0019739 19 GTEx DepMap Descartes 2.47 4.70
FN1 0.0019504 21 GTEx DepMap Descartes 5.06 23.52
COL12A1 0.0018242 28 GTEx DepMap Descartes 1.95 4.75
BGN 0.0018053 30 GTEx DepMap Descartes 3.04 96.42
DCN 0.0012615 103 GTEx DepMap Descartes 5.78 42.80
TPM1 0.0011918 118 GTEx DepMap Descartes 13.92 167.40
LUM 0.0011886 119 GTEx DepMap Descartes 2.61 101.48
CNN2 0.0011102 163 GTEx DepMap Descartes 3.70 145.88
COL14A1 0.0010569 184 GTEx DepMap Descartes 1.79 2.61
IGFBP7 0.0010544 186 GTEx DepMap Descartes 0.35 1.81
TMEM119 0.0010380 192 GTEx DepMap Descartes 0.81 45.40
COL8A1 0.0010246 202 GTEx DepMap Descartes 0.53 1.17
MMP11 0.0009073 266 GTEx DepMap Descartes 0.86 21.69
TGFBR2 0.0008840 284 GTEx DepMap Descartes 0.40 1.29
VCAN 0.0008524 302 GTEx DepMap Descartes 4.67 14.98
TGFB2 0.0008253 324 GTEx DepMap Descartes 2.28 9.30
CNN3 0.0007794 367 GTEx DepMap Descartes 5.97 49.01
IGFBP3 0.0007713 385 GTEx DepMap Descartes 1.49 50.65
COL4A1 0.0007618 393 GTEx DepMap Descartes 2.25 5.63
TNC 0.0007158 441 GTEx DepMap Descartes 0.78 2.48
MMP2 0.0006829 482 GTEx DepMap Descartes 2.22 29.81
THBS2 0.0006379 549 GTEx DepMap Descartes 0.47 4.90
THBS1 0.0005745 654 GTEx DepMap Descartes 1.03 15.39
POSTN 0.0005724 656 GTEx DepMap Descartes 4.05 33.58
COL13A1 0.0004122 1040 GTEx DepMap Descartes 0.19 0.45
WNT5A 0.0003853 1127 GTEx DepMap Descartes 0.86 11.49
RGS5 0.0003629 1222 GTEx DepMap Descartes 0.18 1.46
VEGFA 0.0003297 1406 GTEx DepMap Descartes 0.45 8.34
PGF 0.0002260 2146 GTEx DepMap Descartes 0.30 9.61
TAGLN 0.0001062 4063 GTEx DepMap Descartes 1.77 60.03
THY1 0.0001038 4125 GTEx DepMap Descartes 0.14 7.38
TGFB1 0.0001010 4181 GTEx DepMap Descartes 0.12 2.28
TGFBR1 0.0000415 6200 GTEx DepMap Descartes 0.74 3.33
COL15A1 -0.0000057 8906 GTEx DepMap Descartes 0.07 0.21
MYL9 -0.0000299 11039 GTEx DepMap Descartes 3.44 152.74
TPM2 -0.0000397 11880 GTEx DepMap Descartes 2.14 53.34
MYLK -0.0000487 12566 GTEx DepMap Descartes 0.87 0.88
COL10A1 -0.0000643 13573 GTEx DepMap Descartes 0.00 0.06
ITGA7 -0.0001570 16621 GTEx DepMap Descartes 0.01 0.07
HOPX -0.0001701 16880 GTEx DepMap Descartes 0.17 1.35
MEF2C -0.0002439 17875 GTEx DepMap Descartes 1.11 1.58
COL11A1 -0.0002474 17903 GTEx DepMap Descartes 4.03 5.82
MYH11 -0.0003178 18466 GTEx DepMap Descartes 0.58 0.87
ACTA2 -0.0003302 18535 GTEx DepMap Descartes 5.07 69.17
ACTG2 -0.0003318 18543 GTEx DepMap Descartes 1.03 6.18


Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.34e-10
Mean rank of genes in gene set: 114.08
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A2 0.0028180 5 GTEx DepMap Descartes 15.45 118.86
COL1A1 0.0026634 7 GTEx DepMap Descartes 13.21 247.54
COL3A1 0.0026041 9 GTEx DepMap Descartes 17.30 130.82
BGN 0.0018053 30 GTEx DepMap Descartes 3.04 96.42
PDGFRA 0.0015469 49 GTEx DepMap Descartes 1.70 12.56
COL6A2 0.0015247 53 GTEx DepMap Descartes 1.94 26.01
DCN 0.0012615 103 GTEx DepMap Descartes 5.78 42.80
SPARC 0.0012598 104 GTEx DepMap Descartes 18.23 197.95
PRRX1 0.0012169 111 GTEx DepMap Descartes 2.56 12.60
LUM 0.0011886 119 GTEx DepMap Descartes 2.61 101.48
LEPR 0.0011578 136 GTEx DepMap Descartes 0.07 0.26
MGP 0.0008198 327 GTEx DepMap Descartes 2.36 222.68
CALD1 0.0007232 430 GTEx DepMap Descartes 8.74 14.53


Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.12e-09
Mean rank of genes in gene set: 383.83
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FSTL1 0.0023451 13 GTEx DepMap Descartes 5.54 29.46
FBN2 0.0022813 14 GTEx DepMap Descartes 3.77 5.82
COL5A2 0.0020655 18 GTEx DepMap Descartes 3.98 8.85
GAS1 0.0012057 115 GTEx DepMap Descartes 4.72 422.22
FBN1 0.0011182 155 GTEx DepMap Descartes 1.28 1.95
COL14A1 0.0010569 184 GTEx DepMap Descartes 1.79 2.61
GSN 0.0007967 345 GTEx DepMap Descartes 1.44 8.69
PENK 0.0006154 581 GTEx DepMap Descartes 1.18 70.04
POSTN 0.0005724 656 GTEx DepMap Descartes 4.05 33.58
ITM2A 0.0005465 703 GTEx DepMap Descartes 9.80 446.80
IGFBP5 0.0004695 871 GTEx DepMap Descartes 10.52 166.43
SFRP1 0.0004390 951 GTEx DepMap Descartes 3.23 26.59




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15065.58
Median rank of genes in gene set: 17759.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
AKAP12 0.0029162 3 GTEx DepMap Descartes 3.41 10.73
STRA6 0.0011704 131 GTEx DepMap Descartes 0.36 1.19
RBP1 0.0010943 171 GTEx DepMap Descartes 4.62 49.75
GRB10 0.0009626 235 GTEx DepMap Descartes 6.81 18.07
PEG3 0.0008898 281 GTEx DepMap Descartes 10.46 107.71
BMP7 0.0008521 304 GTEx DepMap Descartes 0.65 2.62
DLK1 0.0006211 573 GTEx DepMap Descartes 10.08 279.25
EML4 0.0005136 762 GTEx DepMap Descartes 1.68 3.59
MCM6 0.0005126 764 GTEx DepMap Descartes 1.82 17.28
SLIT3 0.0004970 799 GTEx DepMap Descartes 0.53 0.30
CDC42EP3 0.0004371 958 GTEx DepMap Descartes 0.96 11.87
RBMS3 0.0004100 1047 GTEx DepMap Descartes 1.62 0.29
TTC8 0.0003695 1188 GTEx DepMap Descartes 0.26 1.01
RGS5 0.0003629 1222 GTEx DepMap Descartes 0.18 1.46
TMTC4 0.0002854 1676 GTEx DepMap Descartes 0.51 2.21
HS6ST2 0.0002400 2014 GTEx DepMap Descartes 0.56 0.53
TENM4 0.0002256 2153 GTEx DepMap Descartes 1.26 0.60
MSH6 0.0002243 2168 GTEx DepMap Descartes 0.56 8.73
GPR27 0.0002191 2213 GTEx DepMap Descartes 0.50 71.63
MCM2 0.0002103 2293 GTEx DepMap Descartes 0.99 15.27
CETN3 0.0001973 2447 GTEx DepMap Descartes 2.17 35.26
PRIM1 0.0001790 2699 GTEx DepMap Descartes 0.87 15.12
DNAJB1 0.0001653 2883 GTEx DepMap Descartes 1.06 74.01
PIK3R1 0.0001590 2988 GTEx DepMap Descartes 1.12 3.56
SEPT6 0.0001448 3234 GTEx DepMap Descartes 1.12 4.31
NCOA7 0.0001399 3334 GTEx DepMap Descartes 0.53 0.91
ANKRD46 0.0001397 3337 GTEx DepMap Descartes 0.54 8.45
SYNPO2 0.0001393 3340 GTEx DepMap Descartes 0.26 0.38
NET1 0.0001386 3354 GTEx DepMap Descartes 1.12 7.67
IRS2 0.0001385 3361 GTEx DepMap Descartes 0.48 6.12


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.08e-130
Mean rank of genes in gene set: 3440.43
Median rank of genes in gene set: 1199
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL1A1 0.0026634 7 GTEx DepMap Descartes 13.21 247.54
COL3A1 0.0026041 9 GTEx DepMap Descartes 17.30 130.82
LGALS1 0.0025008 10 GTEx DepMap Descartes 19.91 1598.66
FSTL1 0.0023451 13 GTEx DepMap Descartes 5.54 29.46
FBN2 0.0022813 14 GTEx DepMap Descartes 3.77 5.82
COL5A2 0.0020655 18 GTEx DepMap Descartes 3.98 8.85
COL5A1 0.0019739 19 GTEx DepMap Descartes 2.47 4.70
FN1 0.0019504 21 GTEx DepMap Descartes 5.06 23.52
CDH11 0.0019397 22 GTEx DepMap Descartes 2.71 5.11
COL12A1 0.0018242 28 GTEx DepMap Descartes 1.95 4.75
BGN 0.0018053 30 GTEx DepMap Descartes 3.04 96.42
AEBP1 0.0017896 33 GTEx DepMap Descartes 0.66 24.21
COL6A1 0.0017167 37 GTEx DepMap Descartes 2.29 45.51
COL6A3 0.0016097 43 GTEx DepMap Descartes 1.44 5.64
ZFP36L1 0.0015983 44 GTEx DepMap Descartes 4.36 205.54
CFH 0.0015849 45 GTEx DepMap Descartes 0.20 0.57
MEST 0.0015582 48 GTEx DepMap Descartes 18.71 217.47
COL6A2 0.0015247 53 GTEx DepMap Descartes 1.94 26.01
EGR1 0.0015169 56 GTEx DepMap Descartes 13.06 796.69
SERPINH1 0.0015080 58 GTEx DepMap Descartes 15.05 532.68
CD63 0.0014747 62 GTEx DepMap Descartes 7.82 210.66
OLFML3 0.0014537 65 GTEx DepMap Descartes 1.68 40.09
LAPTM4A 0.0014199 71 GTEx DepMap Descartes 6.68 121.80
PPIC 0.0014061 74 GTEx DepMap Descartes 3.07 68.36
CXCL12 0.0013718 77 GTEx DepMap Descartes 2.21 64.89
LOXL2 0.0013525 80 GTEx DepMap Descartes 1.53 5.69
RHOJ 0.0013265 84 GTEx DepMap Descartes 0.58 1.98
ITM2C 0.0013195 88 GTEx DepMap Descartes 1.83 37.29
RHOC 0.0013172 90 GTEx DepMap Descartes 3.29 182.18
GAS2 0.0013156 91 GTEx DepMap Descartes 1.64 4.52


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12127.9
Median rank of genes in gene set: 14929.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PEG3 0.0008898 281 GTEx DepMap Descartes 10.46 107.71
GSTA4 0.0006379 548 GTEx DepMap Descartes 1.86 23.59
FDX1 0.0006079 595 GTEx DepMap Descartes 0.85 10.31
SLC16A9 0.0003413 1349 GTEx DepMap Descartes 0.04 0.35
BAIAP2L1 0.0002797 1713 GTEx DepMap Descartes 0.10 0.28
SH3PXD2B 0.0002429 1988 GTEx DepMap Descartes 0.49 1.62
CLU 0.0002090 2311 GTEx DepMap Descartes 0.34 7.50
MC2R 0.0001441 3248 GTEx DepMap Descartes 0.01 0.08
NPC1 0.0000496 5849 GTEx DepMap Descartes 0.32 1.93
SH3BP5 0.0000214 7225 GTEx DepMap Descartes 0.52 2.07
POR 0.0000211 7248 GTEx DepMap Descartes 0.63 3.00
CYP17A1 0.0000149 7626 GTEx DepMap Descartes 0.00 0.01
SCARB1 0.0000099 7929 GTEx DepMap Descartes 0.22 0.89
ERN1 0.0000035 8304 GTEx DepMap Descartes 0.04 0.11
IGF1R 0.0000032 8323 GTEx DepMap Descartes 1.68 1.47
SCAP -0.0000029 8711 GTEx DepMap Descartes 0.29 1.50
PDE10A -0.0000327 11290 GTEx DepMap Descartes 0.34 0.20
SGCZ -0.0000458 12365 GTEx DepMap Descartes 0.02 0.01
INHA -0.0000704 13894 GTEx DepMap Descartes 0.11 8.51
STAR -0.0000845 14529 GTEx DepMap Descartes 0.01 0.16
LDLR -0.0000888 14714 GTEx DepMap Descartes 0.25 2.30
FDXR -0.0001000 15145 GTEx DepMap Descartes 0.17 5.39
DHCR24 -0.0001019 15216 GTEx DepMap Descartes 0.58 4.73
CYP11A1 -0.0001164 15641 GTEx DepMap Descartes 0.00 0.02
DHCR7 -0.0001267 15936 GTEx DepMap Descartes 0.37 3.79
CYB5B -0.0001378 16210 GTEx DepMap Descartes 0.58 3.41
CYP11B1 -0.0001489 16467 GTEx DepMap Descartes 0.00 0.00
TM7SF2 -0.0001505 16496 GTEx DepMap Descartes 0.12 5.38
GRAMD1B -0.0001776 17010 GTEx DepMap Descartes 0.07 0.06
MSMO1 -0.0002189 17591 GTEx DepMap Descartes 0.86 14.93


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 14572.43
Median rank of genes in gene set: 17485
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMEM132C 0.0009600 237 GTEx DepMap Descartes 0.53 0.47
EYA4 0.0002939 1616 GTEx DepMap Descartes 0.11 0.15
GREM1 0.0002267 2140 GTEx DepMap Descartes 0.14 3.55
RGMB 0.0001491 3156 GTEx DepMap Descartes 0.49 4.48
SYNPO2 0.0001393 3340 GTEx DepMap Descartes 0.26 0.38
ALK 0.0000460 6012 GTEx DepMap Descartes 0.00 0.00
PTCHD1 0.0000255 7001 GTEx DepMap Descartes 0.04 0.19
IL7 0.0000188 7396 GTEx DepMap Descartes 0.00 0.02
SLC44A5 0.0000004 8514 GTEx DepMap Descartes 0.02 0.01
CNTFR -0.0000193 10057 GTEx DepMap Descartes 0.64 5.60
CCND1 -0.0000209 10209 GTEx DepMap Descartes 3.19 81.93
ANKFN1 -0.0000383 11766 GTEx DepMap Descartes 0.00 0.00
EPHA6 -0.0000424 12089 GTEx DepMap Descartes 0.00 0.00
EYA1 -0.0000696 13860 GTEx DepMap Descartes 0.28 0.64
CNKSR2 -0.0000954 14976 GTEx DepMap Descartes 0.17 0.21
KCNB2 -0.0001143 15573 GTEx DepMap Descartes 0.12 0.08
FAT3 -0.0001329 16087 GTEx DepMap Descartes 0.27 0.14
SLC6A2 -0.0001489 16469 GTEx DepMap Descartes 0.01 0.06
RYR2 -0.0001554 16589 GTEx DepMap Descartes 0.06 0.02
RPH3A -0.0001607 16708 GTEx DepMap Descartes 0.01 0.03
HMX1 -0.0001743 16959 GTEx DepMap Descartes 0.04 0.41
HS3ST5 -0.0002056 17425 GTEx DepMap Descartes 0.03 0.03
MAB21L1 -0.0002149 17545 GTEx DepMap Descartes 0.21 26.97
PRPH -0.0002458 17894 GTEx DepMap Descartes 0.86 23.26
GAL -0.0002467 17896 GTEx DepMap Descartes 0.25 6.12
NTRK1 -0.0002536 17969 GTEx DepMap Descartes 0.41 3.13
MAB21L2 -0.0002718 18128 GTEx DepMap Descartes 0.49 38.26
MARCH11 -0.0002837 18225 GTEx DepMap Descartes 0.05 0.10
NPY -0.0003192 18476 GTEx DepMap Descartes 0.55 31.33
TMEFF2 -0.0003265 18516 GTEx DepMap Descartes 0.32 0.27


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.45e-01
Mean rank of genes in gene set: 9077.7
Median rank of genes in gene set: 9743
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ESM1 0.0011939 117 GTEx DepMap Descartes 0.00 0.05
ARHGAP29 0.0009842 223 GTEx DepMap Descartes 0.75 2.69
RAMP2 0.0008649 294 GTEx DepMap Descartes 0.78 20.26
GALNT15 0.0007725 383 GTEx DepMap Descartes 0.00 0.00
ID1 0.0004644 886 GTEx DepMap Descartes 4.60 1170.87
CDH5 0.0004314 982 GTEx DepMap Descartes 0.06 0.29
EFNB2 0.0003843 1129 GTEx DepMap Descartes 0.63 3.30
CALCRL 0.0003106 1525 GTEx DepMap Descartes 0.11 0.36
HYAL2 0.0001757 2742 GTEx DepMap Descartes 0.77 41.47
ECSCR 0.0001745 2760 GTEx DepMap Descartes 0.09 2.68
SLCO2A1 0.0001737 2766 GTEx DepMap Descartes 0.05 0.14
CYP26B1 0.0001566 3030 GTEx DepMap Descartes 0.23 3.86
TEK 0.0001172 3787 GTEx DepMap Descartes 0.05 0.09
KANK3 0.0000859 4616 GTEx DepMap Descartes 0.10 2.44
MMRN2 0.0000732 5030 GTEx DepMap Descartes 0.02 0.18
SHE 0.0000606 5451 GTEx DepMap Descartes 0.02 0.28
F8 0.0000574 5560 GTEx DepMap Descartes 0.03 0.05
SHANK3 0.0000506 5814 GTEx DepMap Descartes 0.03 0.11
NPR1 0.0000100 7927 GTEx DepMap Descartes 0.03 0.64
TMEM88 0.0000099 7930 GTEx DepMap Descartes 0.09 11.00
CEACAM1 -0.0000132 9534 GTEx DepMap Descartes 0.00 0.13
DNASE1L3 -0.0000157 9743 GTEx DepMap Descartes 0.00 0.00
FCGR2B -0.0000230 10430 GTEx DepMap Descartes 0.00 0.03
CRHBP -0.0000444 12261 GTEx DepMap Descartes 0.01 0.19
NOTCH4 -0.0000482 12534 GTEx DepMap Descartes 0.04 0.58
PTPRB -0.0000497 12627 GTEx DepMap Descartes 0.01 0.02
MYRIP -0.0000521 12793 GTEx DepMap Descartes 0.01 0.01
CHRM3 -0.0000630 13504 GTEx DepMap Descartes 0.01 0.01
CLDN5 -0.0000649 13599 GTEx DepMap Descartes 0.05 7.92
BTNL9 -0.0000656 13646 GTEx DepMap Descartes 0.00 0.01


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.09e-25
Mean rank of genes in gene set: 1267.04
Median rank of genes in gene set: 205
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL1A2 0.0028180 5 GTEx DepMap Descartes 15.45 118.86
COL1A1 0.0026634 7 GTEx DepMap Descartes 13.21 247.54
CLDN11 0.0026631 8 GTEx DepMap Descartes 0.50 13.16
COL3A1 0.0026041 9 GTEx DepMap Descartes 17.30 130.82
ISLR 0.0020762 17 GTEx DepMap Descartes 1.65 10.38
CDH11 0.0019397 22 GTEx DepMap Descartes 2.71 5.11
CD248 0.0019281 23 GTEx DepMap Descartes 0.97 119.41
COL12A1 0.0018242 28 GTEx DepMap Descartes 1.95 4.75
PCOLCE 0.0016908 39 GTEx DepMap Descartes 1.73 66.22
COL6A3 0.0016097 43 GTEx DepMap Descartes 1.44 5.64
LOX 0.0015811 46 GTEx DepMap Descartes 0.97 20.93
PDGFRA 0.0015469 49 GTEx DepMap Descartes 1.70 12.56
LAMC3 0.0014758 61 GTEx DepMap Descartes 0.03 0.29
OGN 0.0014719 63 GTEx DepMap Descartes 1.90 38.49
BICC1 0.0013209 86 GTEx DepMap Descartes 1.41 1.98
GAS2 0.0013156 91 GTEx DepMap Descartes 1.64 4.52
DCN 0.0012615 103 GTEx DepMap Descartes 5.78 42.80
PRRX1 0.0012169 111 GTEx DepMap Descartes 2.56 12.60
LUM 0.0011886 119 GTEx DepMap Descartes 2.61 101.48
PCDH18 0.0011555 137 GTEx DepMap Descartes 1.26 27.86
DKK2 0.0011269 149 GTEx DepMap Descartes 0.96 2.65
CCDC80 0.0010721 178 GTEx DepMap Descartes 1.01 9.83
EDNRA 0.0010289 200 GTEx DepMap Descartes 0.45 2.18
LRRC17 0.0010043 210 GTEx DepMap Descartes 0.97 8.43
ADAMTS2 0.0009228 254 GTEx DepMap Descartes 0.25 0.37
SFRP2 0.0008446 310 GTEx DepMap Descartes 4.30 174.63
MGP 0.0008198 327 GTEx DepMap Descartes 2.36 222.68
IGFBP3 0.0007713 385 GTEx DepMap Descartes 1.49 50.65
ABCC9 0.0007256 428 GTEx DepMap Descartes 0.11 0.24
SCARA5 0.0006953 470 GTEx DepMap Descartes 0.10 0.37


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13173.24
Median rank of genes in gene set: 16630
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PENK 0.0006154 581 GTEx DepMap Descartes 1.18 70.04
NTNG1 0.0003927 1102 GTEx DepMap Descartes 0.46 0.43
CNTN3 0.0003192 1478 GTEx DepMap Descartes 0.06 0.04
ROBO1 0.0002345 2064 GTEx DepMap Descartes 0.60 0.23
GALNTL6 0.0001874 2575 GTEx DepMap Descartes 0.04 0.01
SORCS3 0.0001490 3159 GTEx DepMap Descartes 0.11 0.06
SLC35F3 0.0000654 5293 GTEx DepMap Descartes 0.02 0.03
CDH18 0.0000483 5910 GTEx DepMap Descartes 0.02 0.01
AGBL4 0.0000103 7902 GTEx DepMap Descartes 0.00 0.00
GRM7 0.0000100 7922 GTEx DepMap Descartes 0.02 0.01
KCTD16 0.0000096 7947 GTEx DepMap Descartes 0.00 0.00
ARC 0.0000062 8144 GTEx DepMap Descartes 0.04 3.59
HTATSF1 -0.0000254 10633 GTEx DepMap Descartes 1.69 34.16
CDH12 -0.0000362 11595 GTEx DepMap Descartes 0.01 0.00
FGF14 -0.0000535 12899 GTEx DepMap Descartes 0.01 0.00
SLC24A2 -0.0000582 13207 GTEx DepMap Descartes 0.02 0.02
PNMT -0.0000615 13410 GTEx DepMap Descartes 0.01 1.94
EML6 -0.0000949 14957 GTEx DepMap Descartes 0.01 0.01
TBX20 -0.0000985 15088 GTEx DepMap Descartes 0.08 0.26
TIAM1 -0.0001457 16385 GTEx DepMap Descartes 0.42 0.26
TENM1 -0.0001502 16487 GTEx DepMap Descartes 0.04 0.01
SCG2 -0.0001639 16773 GTEx DepMap Descartes 0.03 1.07
SPOCK3 -0.0001645 16787 GTEx DepMap Descartes 0.24 0.17
CCSER1 -0.0001712 16897 GTEx DepMap Descartes 0.04 0.01
C1QL1 -0.0001800 17053 GTEx DepMap Descartes 0.13 4.44
PACRG -0.0001811 17068 GTEx DepMap Descartes 0.03 0.02
GRID2 -0.0001976 17304 GTEx DepMap Descartes 0.13 0.02
MGAT4C -0.0002055 17424 GTEx DepMap Descartes 0.03 0.02
LAMA3 -0.0002298 17713 GTEx DepMap Descartes 0.07 0.04
CHGB -0.0002370 17800 GTEx DepMap Descartes 0.24 4.04


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.64e-01
Mean rank of genes in gene set: 9579.97
Median rank of genes in gene set: 11465
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GYPC 0.0008713 291 GTEx DepMap Descartes 0.37 3.61
BLVRB 0.0004622 891 GTEx DepMap Descartes 0.65 10.84
SELENBP1 0.0003565 1254 GTEx DepMap Descartes 0.35 9.20
MARCH3 0.0002847 1681 GTEx DepMap Descartes 0.02 0.05
CR1L 0.0002803 1708 GTEx DepMap Descartes 0.53 4.37
CAT 0.0001712 2804 GTEx DepMap Descartes 0.68 6.42
SLC25A21 0.0001146 3847 GTEx DepMap Descartes 0.01 0.01
RGS6 0.0001054 4088 GTEx DepMap Descartes 0.04 0.02
TFR2 0.0001026 4151 GTEx DepMap Descartes 0.01 0.15
DENND4A 0.0000971 4299 GTEx DepMap Descartes 0.09 0.21
RAPGEF2 0.0000743 5000 GTEx DepMap Descartes 0.36 0.47
FECH 0.0000703 5139 GTEx DepMap Descartes 0.42 3.52
MICAL2 0.0000520 5754 GTEx DepMap Descartes 0.08 0.10
SPECC1 0.0000488 5889 GTEx DepMap Descartes 0.34 0.35
ABCB10 0.0000171 7489 GTEx DepMap Descartes 0.20 1.69
RHD 0.0000125 7764 GTEx DepMap Descartes 0.01 0.13
TMEM56 -0.0000101 9253 GTEx DepMap Descartes 0.02 0.05
EPB42 -0.0000296 11021 GTEx DepMap Descartes 0.00 0.00
SLC25A37 -0.0000400 11909 GTEx DepMap Descartes 0.16 0.79
SLC4A1 -0.0000488 12571 GTEx DepMap Descartes 0.00 0.00
RHAG -0.0000530 12863 GTEx DepMap Descartes 0.00 0.00
GYPA -0.0000541 12948 GTEx DepMap Descartes 0.00 0.01
HEMGN -0.0000542 12954 GTEx DepMap Descartes 0.00 0.03
SOX6 -0.0000555 13033 GTEx DepMap Descartes 0.54 0.26
TRAK2 -0.0000557 13053 GTEx DepMap Descartes 0.18 0.70
SPTA1 -0.0000566 13114 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0000578 13177 GTEx DepMap Descartes 0.01 0.05
CPOX -0.0000695 13851 GTEx DepMap Descartes 0.27 1.38
SNCA -0.0000822 14442 GTEx DepMap Descartes 0.14 0.22
XPO7 -0.0000872 14641 GTEx DepMap Descartes 0.58 1.46


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.53e-02
Mean rank of genes in gene set: 7983.36
Median rank of genes in gene set: 7775.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TGFBI 0.0015277 52 GTEx DepMap Descartes 2.42 29.52
SLC1A3 0.0011541 138 GTEx DepMap Descartes 1.11 5.03
AXL 0.0007767 375 GTEx DepMap Descartes 0.83 9.13
RGL1 0.0006275 567 GTEx DepMap Descartes 0.42 0.48
ABCA1 0.0005290 726 GTEx DepMap Descartes 0.25 0.59
ADAP2 0.0004561 907 GTEx DepMap Descartes 0.00 0.07
MERTK 0.0004217 1019 GTEx DepMap Descartes 0.14 0.45
ITPR2 0.0002875 1658 GTEx DepMap Descartes 0.22 0.21
IFNGR1 0.0002832 1691 GTEx DepMap Descartes 0.28 4.22
HCK 0.0002715 1766 GTEx DepMap Descartes 0.03 0.19
CTSB 0.0002682 1786 GTEx DepMap Descartes 1.79 23.43
SLCO2B1 0.0002436 1976 GTEx DepMap Descartes 0.00 0.01
CST3 0.0001867 2582 GTEx DepMap Descartes 5.56 407.02
SFMBT2 0.0001380 3368 GTEx DepMap Descartes 0.05 0.08
RBPJ 0.0001377 3375 GTEx DepMap Descartes 0.92 1.32
CTSD 0.0001237 3631 GTEx DepMap Descartes 1.92 50.28
SPP1 0.0000563 5597 GTEx DepMap Descartes 0.12 3.83
ATP8B4 0.0000405 6240 GTEx DepMap Descartes 0.00 0.00
SLC9A9 0.0000350 6493 GTEx DepMap Descartes 0.05 0.02
CPVL 0.0000225 7178 GTEx DepMap Descartes 0.00 0.00
WWP1 0.0000212 7242 GTEx DepMap Descartes 0.47 1.19
MSR1 0.0000035 8309 GTEx DepMap Descartes 0.00 0.01
LGMN -0.0000171 9867 GTEx DepMap Descartes 0.43 2.30
RNASE1 -0.0000290 10948 GTEx DepMap Descartes 0.00 0.00
MS4A7 -0.0000292 10976 GTEx DepMap Descartes 0.00 0.00
MS4A4A -0.0000325 11266 GTEx DepMap Descartes 0.00 0.00
HRH1 -0.0000364 11615 GTEx DepMap Descartes 0.00 0.00
C1QA -0.0000428 12113 GTEx DepMap Descartes 0.03 2.49
FGL2 -0.0000435 12186 GTEx DepMap Descartes 0.02 0.82
CD14 -0.0000483 12545 GTEx DepMap Descartes 0.01 0.94


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.06e-01
Mean rank of genes in gene set: 10367.87
Median rank of genes in gene set: 13598
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL5A2 0.0020655 18 GTEx DepMap Descartes 3.98 8.85
PMP22 0.0008984 274 GTEx DepMap Descartes 2.15 23.21
PTN 0.0008765 288 GTEx DepMap Descartes 15.57 43.79
VCAN 0.0008524 302 GTEx DepMap Descartes 4.67 14.98
EGFLAM 0.0007771 374 GTEx DepMap Descartes 0.38 0.76
KCTD12 0.0007460 412 GTEx DepMap Descartes 2.16 117.53
LAMA4 0.0005705 659 GTEx DepMap Descartes 1.09 2.19
LAMB1 0.0004881 823 GTEx DepMap Descartes 1.75 7.11
MARCKS 0.0004577 904 GTEx DepMap Descartes 12.76 593.45
SFRP1 0.0004390 951 GTEx DepMap Descartes 3.23 26.59
VIM 0.0004234 1012 GTEx DepMap Descartes 17.66 475.35
LAMC1 0.0003641 1217 GTEx DepMap Descartes 0.60 1.16
COL25A1 0.0003236 1441 GTEx DepMap Descartes 0.46 0.33
PLCE1 0.0002663 1803 GTEx DepMap Descartes 0.38 0.36
IL1RAPL2 0.0001317 3474 GTEx DepMap Descartes 0.03 0.01
LRRTM4 0.0001103 3934 GTEx DepMap Descartes 0.04 0.02
GAS7 0.0000861 4609 GTEx DepMap Descartes 0.26 0.26
HMGA2 0.0000702 5144 GTEx DepMap Descartes 7.15 20.43
PAG1 0.0000618 5410 GTEx DepMap Descartes 0.20 0.33
OLFML2A 0.0000522 5744 GTEx DepMap Descartes 0.08 0.42
COL18A1 0.0000477 5930 GTEx DepMap Descartes 1.27 2.33
ADAMTS5 0.0000424 6159 GTEx DepMap Descartes 0.44 2.00
STARD13 -0.0000318 11207 GTEx DepMap Descartes 0.15 0.16
IL1RAPL1 -0.0000649 13598 GTEx DepMap Descartes 0.07 0.01
TRPM3 -0.0000713 13930 GTEx DepMap Descartes 0.03 0.01
SCN7A -0.0001014 15202 GTEx DepMap Descartes 0.03 0.03
GRIK3 -0.0001309 16038 GTEx DepMap Descartes 0.03 0.04
SOX5 -0.0001363 16168 GTEx DepMap Descartes 0.59 0.19
MDGA2 -0.0001471 16421 GTEx DepMap Descartes 0.08 0.03
SORCS1 -0.0001508 16502 GTEx DepMap Descartes 0.13 0.06


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.10e-01
Mean rank of genes in gene set: 9010.23
Median rank of genes in gene set: 10467
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ANGPT1 0.0011086 164 GTEx DepMap Descartes 0.31 0.38
TPM4 0.0010676 181 GTEx DepMap Descartes 3.51 40.66
LTBP1 0.0010184 203 GTEx DepMap Descartes 0.99 0.76
FLNA 0.0008099 337 GTEx DepMap Descartes 3.45 35.45
GSN 0.0007967 345 GTEx DepMap Descartes 1.44 8.69
ZYX 0.0006172 579 GTEx DepMap Descartes 2.04 57.50
THBS1 0.0005745 654 GTEx DepMap Descartes 1.03 15.39
TLN1 0.0005545 685 GTEx DepMap Descartes 2.00 17.85
FLI1 0.0005471 702 GTEx DepMap Descartes 0.33 0.90
RAP1B 0.0004416 946 GTEx DepMap Descartes 2.04 19.89
LIMS1 0.0004278 993 GTEx DepMap Descartes 1.26 3.08
ACTN1 0.0004277 994 GTEx DepMap Descartes 1.33 4.12
PDE3A 0.0003753 1170 GTEx DepMap Descartes 0.26 0.28
VCL 0.0003653 1208 GTEx DepMap Descartes 0.80 1.86
ARHGAP6 0.0003065 1545 GTEx DepMap Descartes 0.10 0.05
INPP4B 0.0003051 1549 GTEx DepMap Descartes 0.12 0.05
TGFB1 0.0001010 4181 GTEx DepMap Descartes 0.12 2.28
STOM 0.0000885 4544 GTEx DepMap Descartes 0.14 2.01
MYH9 0.0000581 5533 GTEx DepMap Descartes 1.05 2.87
TRPC6 0.0000142 7670 GTEx DepMap Descartes 0.01 0.01
PPBP 0.0000041 8267 GTEx DepMap Descartes 0.01 1.55
ITGA2B 0.0000014 8450 GTEx DepMap Descartes 0.04 0.69
PSTPIP2 -0.0000156 9737 GTEx DepMap Descartes 0.00 0.01
P2RX1 -0.0000233 10467 GTEx DepMap Descartes 0.00 0.04
GP9 -0.0000393 11853 GTEx DepMap Descartes 0.01 0.95
PF4 -0.0000485 12560 GTEx DepMap Descartes 0.09 24.49
MYLK -0.0000487 12566 GTEx DepMap Descartes 0.87 0.88
BIN2 -0.0000521 12791 GTEx DepMap Descartes 0.00 0.01
PLEK -0.0000548 12993 GTEx DepMap Descartes 0.01 0.04
CD84 -0.0000588 13251 GTEx DepMap Descartes 0.00 0.01


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.04e-01
Mean rank of genes in gene set: 10401.24
Median rank of genes in gene set: 12536.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RCSD1 0.0008363 314 GTEx DepMap Descartes 0.31 1.48
B2M 0.0007329 421 GTEx DepMap Descartes 0.91 44.49
CCND3 0.0006595 515 GTEx DepMap Descartes 5.63 17.85
ETS1 0.0005984 607 GTEx DepMap Descartes 0.48 1.19
FOXP1 0.0005672 668 GTEx DepMap Descartes 3.16 1.60
WIPF1 0.0004288 991 GTEx DepMap Descartes 0.28 0.87
ITPKB 0.0002427 1990 GTEx DepMap Descartes 0.34 1.10
PLEKHA2 0.0001990 2425 GTEx DepMap Descartes 0.04 0.20
ARID5B 0.0001919 2514 GTEx DepMap Descartes 0.84 1.33
TMSB10 0.0001856 2603 GTEx DepMap Descartes 31.89 6054.12
CD44 0.0001067 4050 GTEx DepMap Descartes 0.12 0.32
MSN 0.0000910 4471 GTEx DepMap Descartes 0.67 2.34
PDE3B 0.0000827 4724 GTEx DepMap Descartes 0.20 0.45
BCL2 0.0000779 4887 GTEx DepMap Descartes 0.92 1.76
DOCK10 0.0000658 5275 GTEx DepMap Descartes 0.15 0.17
PITPNC1 0.0000532 5699 GTEx DepMap Descartes 0.61 0.63
SP100 0.0000202 7307 GTEx DepMap Descartes 0.00 0.00
STK39 0.0000044 8254 GTEx DepMap Descartes 0.52 0.59
TOX -0.0000034 8732 GTEx DepMap Descartes 0.51 0.58
FAM65B -0.0000378 11718 GTEx DepMap Descartes 0.05 NA
NKG7 -0.0000449 12305 GTEx DepMap Descartes 0.00 0.07
SCML4 -0.0000518 12768 GTEx DepMap Descartes 0.01 0.03
MCTP2 -0.0000561 13084 GTEx DepMap Descartes 0.02 0.02
PTPRC -0.0000679 13773 GTEx DepMap Descartes 0.00 0.00
ARHGAP15 -0.0000792 14293 GTEx DepMap Descartes 0.01 0.00
MBNL1 -0.0000794 14302 GTEx DepMap Descartes 1.02 1.73
ANKRD44 -0.0000905 14791 GTEx DepMap Descartes 0.37 0.43
IKZF1 -0.0000906 14798 GTEx DepMap Descartes 0.00 0.01
LEF1 -0.0001333 16102 GTEx DepMap Descartes 0.54 1.16
NCALD -0.0001414 16288 GTEx DepMap Descartes 0.24 0.13


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.94e-04
Mean rank of genes in gene set: 3066.89
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PDGFRA 0.0015469 49 GTEx DepMap Descartes 1.70 12.56
PRRX1 0.0012169 111 GTEx DepMap Descartes 2.56 12.60
ANGPTL1 0.0009376 247 GTEx DepMap Descartes 1.07 17.85
SMOC2 0.0008257 322 GTEx DepMap Descartes 1.56 3.71
OLFML1 0.0005075 771 GTEx DepMap Descartes 0.12 1.59
SFRP1 0.0004390 951 GTEx DepMap Descartes 3.23 26.59
NTRK2 0.0001972 2449 GTEx DepMap Descartes 0.62 0.74
EBF2 0.0000008 8494 GTEx DepMap Descartes 0.89 1.59
F10 -0.0000775 14208 GTEx DepMap Descartes 0.00 0.02


Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.40e-03
Mean rank of genes in gene set: 38.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A2 0.0028180 5 GTEx DepMap Descartes 15.45 118.86
COL1A1 0.0026634 7 GTEx DepMap Descartes 13.21 247.54
DCN 0.0012615 103 GTEx DepMap Descartes 5.78 42.80


Macrophages: Kupffer cells (model markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.08e-02
Mean rank of genes in gene set: 4435.83
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PENK 0.0006154 581 GTEx DepMap Descartes 1.18 70.04
EGR2 0.0002033 2377 GTEx DepMap Descartes 0.27 12.23
ECSCR 0.0001745 2760 GTEx DepMap Descartes 0.09 2.68
ARRDC3 0.0000869 4584 GTEx DepMap Descartes 0.48 10.40
CD5L 0.0000288 6798 GTEx DepMap Descartes 0.00 0.01
TCHH -0.0000131 9515 GTEx DepMap Descartes 0.06 2.62