Program: 41. IFN Response: Activity Program.

Program: 41. IFN Response: Activity Program.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 IFIT1 0.0119898 interferon induced protein with tetratricopeptide repeats 1 GTEx DepMap Descartes 3.74 125.06
2 IFI44 0.0118752 interferon induced protein 44 GTEx DepMap Descartes 2.69 240.25
3 IFIT3 0.0109563 interferon induced protein with tetratricopeptide repeats 3 GTEx DepMap Descartes 2.88 178.74
4 IFI27 0.0092068 interferon alpha inducible protein 27 GTEx DepMap Descartes 26.52 1606.78
5 CRABP1 0.0084962 cellular retinoic acid binding protein 1 GTEx DepMap Descartes 2.28 434.81
6 STAT1 0.0083173 signal transducer and activator of transcription 1 GTEx DepMap Descartes 3.98 141.58
7 NOS1 0.0081810 nitric oxide synthase 1 GTEx DepMap Descartes 0.35 4.13
8 SPATS2L 0.0074968 spermatogenesis associated serine rich 2 like GTEx DepMap Descartes 3.55 89.39
9 FGF10 0.0073169 fibroblast growth factor 10 GTEx DepMap Descartes 0.49 12.14
10 EIF2AK2 0.0071824 eukaryotic translation initiation factor 2 alpha kinase 2 GTEx DepMap Descartes 3.89 57.87
11 CALM1 0.0070880 calmodulin 1 GTEx DepMap Descartes 25.25 900.56
12 CNR1 0.0069005 cannabinoid receptor 1 GTEx DepMap Descartes 0.83 19.91
13 NTS 0.0068891 neurotensin GTEx DepMap Descartes 0.75 102.25
14 FBXO8 0.0062642 F-box protein 8 GTEx DepMap Descartes 1.39 106.09
15 NPY 0.0062200 neuropeptide Y GTEx DepMap Descartes 54.84 11736.49
16 UCHL1 0.0061251 ubiquitin C-terminal hydrolase L1 GTEx DepMap Descartes 21.90 2050.19
17 CSGALNACT1 0.0057991 chondroitin sulfate N-acetylgalactosaminyltransferase 1 GTEx DepMap Descartes 1.87 69.59
18 GREM2 0.0054936 gremlin 2, DAN family BMP antagonist GTEx DepMap Descartes 0.34 11.79
19 NBAS 0.0054123 NBAS subunit of NRZ tethering complex GTEx DepMap Descartes 19.89 354.87
20 HGF 0.0053251 hepatocyte growth factor GTEx DepMap Descartes 2.64 67.00
21 PKIB 0.0051928 cAMP-dependent protein kinase inhibitor beta GTEx DepMap Descartes 3.46 264.02
22 NNAT 0.0051197 neuronatin GTEx DepMap Descartes 7.58 911.70
23 RTN1 0.0050951 reticulon 1 GTEx DepMap Descartes 16.39 763.13
24 NRXN1 0.0050922 neurexin 1 GTEx DepMap Descartes 3.83 64.45
25 PLCB1 0.0050420 phospholipase C beta 1 GTEx DepMap Descartes 0.87 17.74
26 NR2F1 0.0049347 nuclear receptor subfamily 2 group F member 1 GTEx DepMap Descartes 4.42 177.72
27 MGAT4C 0.0049011 MGAT4 family member C GTEx DepMap Descartes 0.90 5.63
28 ARX 0.0048894 aristaless related homeobox GTEx DepMap Descartes 0.71 38.54
29 MAB21L2 0.0048588 mab-21 like 2 GTEx DepMap Descartes 3.11 188.54
30 EEF1A1 0.0047375 eukaryotic translation elongation factor 1 alpha 1 GTEx DepMap Descartes 155.85 5097.37
31 AIG1 0.0047192 androgen induced 1 GTEx DepMap Descartes 2.54 104.34
32 LRRN3 0.0046803 leucine rich repeat neuronal 3 GTEx DepMap Descartes 4.53 184.21
33 PMAIP1 0.0046232 phorbol-12-myristate-13-acetate-induced protein 1 GTEx DepMap Descartes 1.91 153.06
34 THADA 0.0044712 THADA armadillo repeat containing GTEx DepMap Descartes 1.92 41.81
35 CTHRC1 0.0044624 collagen triple helix repeat containing 1 GTEx DepMap Descartes 2.49 293.76
36 GSG1L 0.0044357 GSG1 like GTEx DepMap Descartes 0.18 5.07
37 PITX1 0.0044185 paired like homeodomain 1 GTEx DepMap Descartes 0.19 12.31
38 HMCN1 0.0041778 hemicentin 1 GTEx DepMap Descartes 0.08 0.69
39 TMEM108 0.0041530 transmembrane protein 108 GTEx DepMap Descartes 0.83 25.59
40 OAS3 0.0041313 2’-5’-oligoadenylate synthetase 3 GTEx DepMap Descartes 0.55 12.63
41 SNCG 0.0040906 synuclein gamma GTEx DepMap Descartes 0.66 105.85
42 NAP1L5 0.0040741 nucleosome assembly protein 1 like 5 GTEx DepMap Descartes 1.66 135.46
43 HERC6 0.0040685 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 GTEx DepMap Descartes 0.28 11.25
44 FAM49A 0.0039161 NA GTEx DepMap Descartes 11.62 NA
45 PCDHB6 0.0038871 protocadherin beta 6 GTEx DepMap Descartes 0.66 30.14
46 LGALS3BP 0.0038619 galectin 3 binding protein GTEx DepMap Descartes 2.98 199.68
47 MMD 0.0038208 monocyte to macrophage differentiation associated GTEx DepMap Descartes 2.45 140.40
48 CUTA 0.0038037 cutA divalent cation tolerance homolog GTEx DepMap Descartes 9.49 992.53
49 ADM 0.0037772 adrenomedullin GTEx DepMap Descartes 1.05 88.45
50 RTN4 0.0037733 reticulon 4 GTEx DepMap Descartes 8.20 253.10


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UMAP plots showing activity of gene expression program identified in GEP 41. IFN Response: Activity Program:

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HU_FETAL_RETINA_AMACRINE 1.17e-04 18.10 4.59 1.30e-02 7.82e-02
4CRABP1, NNAT, RTN1, NRXN1
 64
DESCARTES_FETAL_PANCREAS_ENS_NEURONS 4.04e-05 10.85 3.73 1.04e-02 2.71e-02
6CRABP1, NOS1, CNR1, NPY, UCHL1, NNAT
 163
TRAVAGLINI_LUNG_NEUROENDOCRINE_CELL 1.43e-04 11.29 3.44 1.37e-02 9.59e-02
5UCHL1, PKIB, NNAT, NRXN1, PITX1
 128
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MATURE_NEURONS 8.59e-05 9.42 3.24 1.30e-02 5.76e-02
6IFI27, CALM1, UCHL1, RTN1, NRXN1, CUTA
 187
MANNO_MIDBRAIN_NEUROTYPES_HRN 3.98e-05 7.28 2.93 1.04e-02 2.67e-02
8CNR1, UCHL1, GREM2, NNAT, RTN1, NRXN1, SNCG, NAP1L5
 335
DESCARTES_FETAL_MUSCLE_SATELLITE_CELLS 1.55e-03 14.50 2.80 8.69e-02 1.00e+00
3SPATS2L, NPY, GSG1L
 58
MANNO_MIDBRAIN_NEUROTYPES_HSERT 4.67e-05 6.22 2.64 1.04e-02 3.13e-02
9UCHL1, GREM2, RTN1, NRXN1, PLCB1, MGAT4C, CTHRC1, SNCG, NAP1L5
 450
DESCARTES_MAIN_FETAL_CHROMAFFIN_CELLS 4.05e-03 23.65 2.62 1.60e-01 1.00e+00
2NPY, MAB21L2
 24
MENON_FETAL_KIDNEY_5_PROXIMAL_TUBULE_CELLS 9.77e-04 10.06 2.58 8.03e-02 6.56e-01
4SPATS2L, CALM1, AIG1, RTN4
 112
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 1.10e-04 6.25 2.52 1.30e-02 7.40e-02
8UCHL1, GREM2, RTN1, PLCB1, MAB21L2, LRRN3, GSG1L, SNCG
 389
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_OLFACTORY_ENSHEATHING_GLIA 1.08e-03 9.79 2.52 8.03e-02 7.23e-01
4NPY, NRXN1, NR2F1, SNCG
 115
DESCARTES_FETAL_STOMACH_ENS_NEURONS 3.11e-03 11.23 2.19 1.39e-01 1.00e+00
3NOS1, NPY, UCHL1
 74
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_IMMATURE_NEURONS 2.15e-03 8.05 2.08 1.03e-01 1.00e+00
4CALM1, UCHL1, RTN1, NRXN1
 139
FAN_OVARY_CL16_LYMPHATIC_ENDOTHELIAL_CELL 2.06e-03 6.12 1.88 1.03e-01 1.00e+00
5CALM1, NTS, CTHRC1, ADM, RTN4
 232
DESCARTES_FETAL_INTESTINE_ENS_NEURONS 3.55e-03 6.97 1.80 1.49e-01 1.00e+00
4CRABP1, NOS1, CNR1, UCHL1
 160
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_GLOBOSE_BASAL_CELLS 8.47e-03 15.77 1.78 2.27e-01 1.00e+00
2UCHL1, RTN1
 35
HU_FETAL_RETINA_RGC 1.44e-03 4.67 1.76 8.69e-02 9.63e-01
7CRABP1, CNR1, UCHL1, RTN1, LRRN3, SNCG, RTN4
 443
MENON_FETAL_KIDNEY_6_COLLECTING_DUCT_CELLS 6.06e-03 8.76 1.71 2.01e-01 1.00e+00
3SPATS2L, CALM1, RTN4
 94
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_UNSPECIFIED 9.43e-03 14.87 1.69 2.34e-01 1.00e+00
2CALM1, NTS
 37
MANNO_MIDBRAIN_NEUROTYPES_HDA1 1.50e-03 4.14 1.67 8.69e-02 1.00e+00
8CNR1, UCHL1, NNAT, RTN1, NRXN1, PLCB1, NAP1L5, MMD
 584

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_INTERFERON_ALPHA_RESPONSE 2.11e-06 18.72 6.36 5.27e-05 1.05e-04
6IFI44, IFIT3, IFI27, EIF2AK2, HERC6, LGALS3BP
 97
HALLMARK_INTERFERON_GAMMA_RESPONSE 6.91e-08 14.37 6.05 3.45e-06 3.45e-06
9IFIT1, IFI44, IFIT3, IFI27, STAT1, EIF2AK2, OAS3, HERC6, LGALS3BP
 200
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 1.00e+00 1.00e+00
2HGF, PMAIP1
 161
HALLMARK_INFLAMMATORY_RESPONSE 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2EIF2AK2, ADM
 200
HALLMARK_HEDGEHOG_SIGNALING 1.34e-01 7.29 0.18 1.00e+00 1.00e+00
1RTN1
 36
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1STAT1
 87
HALLMARK_PEROXISOME 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1CRABP1
 104
HALLMARK_PI3K_AKT_MTOR_SIGNALING 3.41e-01 2.45 0.06 1.00e+00 1.00e+00
1PLCB1
 105
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 3.62e-01 2.28 0.06 1.00e+00 1.00e+00
1IFIT1
 113
HALLMARK_SPERMATOGENESIS 4.15e-01 1.90 0.05 1.00e+00 1.00e+00
1NOS1
 135
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ADM
 200
HALLMARK_ADIPOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1SNCG
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1PMAIP1
 200
HALLMARK_MYOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1NOS1
 200
HALLMARK_COMPLEMENT 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CALM1
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CTHRC1
 200
HALLMARK_ALLOGRAFT_REJECTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1STAT1
 200
HALLMARK_KRAS_SIGNALING_UP 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1MMD
 200
HALLMARK_KRAS_SIGNALING_DN 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1NOS1
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_ALZHEIMERS_DISEASE 2.74e-02 4.89 0.96 1.00e+00 1.00e+00
3NOS1, CALM1, PLCB1
 166
KEGG_CALCIUM_SIGNALING_PATHWAY 3.26e-02 4.56 0.90 1.00e+00 1.00e+00
3NOS1, CALM1, PLCB1
 178
KEGG_LONG_TERM_POTENTIATION 3.13e-02 7.66 0.88 1.00e+00 1.00e+00
2CALM1, PLCB1
 70
KEGG_LONG_TERM_DEPRESSION 3.13e-02 7.66 0.88 1.00e+00 1.00e+00
2NOS1, PLCB1
 70
KEGG_MELANOMA 3.21e-02 7.55 0.87 1.00e+00 1.00e+00
2FGF10, HGF
 71
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 3.64e-02 7.04 0.81 1.00e+00 1.00e+00
2CALM1, PLCB1
 76
KEGG_GNRH_SIGNALING_PATHWAY 6.04e-02 5.26 0.61 1.00e+00 1.00e+00
2CALM1, PLCB1
 101
KEGG_MELANOGENESIS 6.04e-02 5.26 0.61 1.00e+00 1.00e+00
2CALM1, PLCB1
 101
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 7.56e-02 4.61 0.54 1.00e+00 1.00e+00
2CALM1, PLCB1
 115
KEGG_PATHWAYS_IN_CANCER 1.32e-01 2.48 0.49 1.00e+00 1.00e+00
3STAT1, FGF10, HGF
 325
KEGG_CHEMOKINE_SIGNALING_PATHWAY 1.70e-01 2.79 0.33 1.00e+00 1.00e+00
2STAT1, PLCB1
 189
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE 8.40e-02 12.14 0.29 1.00e+00 1.00e+00
1CSGALNACT1
 22
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 1.90e-01 4.91 0.12 1.00e+00 1.00e+00
1NOS1
 53
KEGG_ARGININE_AND_PROLINE_METABOLISM 1.94e-01 4.81 0.12 1.00e+00 1.00e+00
1NOS1
 54
KEGG_INOSITOL_PHOSPHATE_METABOLISM 1.94e-01 4.81 0.12 1.00e+00 1.00e+00
1PLCB1
 54
KEGG_GLIOMA 2.28e-01 3.99 0.10 1.00e+00 1.00e+00
1CALM1
 65
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 2.34e-01 3.86 0.09 1.00e+00 1.00e+00
1NPY
 67
KEGG_P53_SIGNALING_PATHWAY 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1PMAIP1
 68
KEGG_RENAL_CELL_CARCINOMA 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1HGF
 70
KEGG_PANCREATIC_CANCER 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1STAT1
 70

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr4q22 3.13e-02 7.66 0.88 1.00e+00 1.00e+00
2NAP1L5, HERC6
 70
chr10q23 3.84e-02 4.27 0.84 1.00e+00 1.00e+00
3IFIT1, IFIT3, SNCG
 190
chr2p16 7.44e-02 4.65 0.54 1.00e+00 1.00e+00
2NRXN1, RTN4
 114
chr12q21 9.06e-02 4.13 0.48 1.00e+00 1.00e+00
2NTS, MGAT4C
 128
chr5q31 3.08e-01 1.83 0.21 1.00e+00 1.00e+00
2PITX1, PCDHB6
 287
chr4p13 1.16e-01 8.50 0.20 1.00e+00 1.00e+00
1UCHL1
 31
chr5p12 1.20e-01 8.23 0.20 1.00e+00 1.00e+00
1FGF10
 32
chr12q24 6.63e-01 1.34 0.16 1.00e+00 1.00e+00
2NOS1, OAS3
 390
chr6q15 1.74e-01 5.43 0.13 1.00e+00 1.00e+00
1CNR1
 48
chr6q13 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1EEF1A1
 56
chr14q32 1.00e+00 0.96 0.11 1.00e+00 1.00e+00
2IFI27, CALM1
 546
chr1q43 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1GREM2
 60
chr5q15 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1NR2F1
 60
chr6q24 2.49e-01 3.59 0.09 1.00e+00 1.00e+00
1AIG1
 72
chr2p24 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1NBAS
 74
chr2p21 2.73e-01 3.23 0.08 1.00e+00 1.00e+00
1THADA
 80
chrXp21 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1ARX
 82
chr17q22 2.90e-01 3.00 0.07 1.00e+00 1.00e+00
1MMD
 86
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1NPY
 96
chr2p22 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1EIF2AK2
 98

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
MSX1_01 5.98e-05 10.09 3.46 6.77e-02 6.77e-02
6CALM1, NTS, NR2F1, ARX, MAB21L2, AIG1
 175
RNTCANNRNNYNATTW_UNKNOWN 2.06e-03 13.07 2.53 5.14e-01 1.00e+00
3FGF10, NRXN1, MGAT4C
 64
MEF2_04 4.74e-03 21.66 2.42 5.37e-01 1.00e+00
2NR2F1, CTHRC1
 26
GRE_C 1.64e-03 8.69 2.24 5.14e-01 1.00e+00
4NNAT, NR2F1, ARX, LRRN3
 129
PER1_TARGET_GENES 7.55e-03 16.78 1.89 6.43e-01 1.00e+00
2NTS, EEF1A1
 33
TTCNRGNNNNTTC_HSF_Q6 3.17e-03 7.20 1.86 5.14e-01 1.00e+00
4FGF10, NNAT, RTN1, NR2F1
 155
CP2_02 2.97e-03 5.60 1.72 5.14e-01 1.00e+00
5NNAT, RTN1, NR2F1, ARX, CUTA
 253
OCT1_07 4.22e-03 6.63 1.71 5.31e-01 1.00e+00
4NOS1, PLCB1, NR2F1, MGAT4C
 168
TGANTCA_AP1_C 6.46e-04 3.51 1.66 3.66e-01 7.31e-01
12STAT1, FGF10, RTN1, NRXN1, ARX, EEF1A1, AIG1, LRRN3, CTHRC1, SNCG, ADM, RTN4
 1139
HNF4ALPHA_Q6 3.96e-03 5.22 1.60 5.31e-01 1.00e+00
5FGF10, NR2F1, MAB21L2, CUTA, RTN4
 271
STTTCRNTTT_IRF_Q6 6.70e-03 5.78 1.50 6.33e-01 1.00e+00
4IFI44, IFIT3, HGF, LGALS3BP
 192
TGGAAA_NFAT_Q4_01 2.42e-03 2.79 1.42 5.14e-01 1.00e+00
15NOS1, FGF10, CALM1, CNR1, UCHL1, HGF, NNAT, PLCB1, MAB21L2, AIG1, LRRN3, CTHRC1, TMEM108, NAP1L5, ADM
 1934
RP58_01 9.39e-03 5.22 1.35 6.49e-01 1.00e+00
4FGF10, CALM1, HGF, ARX
 212
TGCCAAR_NF1_Q6 5.41e-03 3.31 1.34 5.57e-01 1.00e+00
8CALM1, HGF, NNAT, PLCB1, NR2F1, MGAT4C, MAB21L2, PITX1
 727
YGCANTGCR_UNKNOWN 1.37e-02 6.43 1.26 6.49e-01 1.00e+00
3HGF, NNAT, NRXN1
 127
CTGCAGY_UNKNOWN 7.94e-03 3.09 1.25 6.43e-01 1.00e+00
8CALM1, HGF, NNAT, NRXN1, NR2F1, MGAT4C, TMEM108, RTN4
 779
NKX3A_01 1.38e-02 4.65 1.20 6.49e-01 1.00e+00
4NNAT, NR2F1, ARX, NAP1L5
 238
YATGNWAAT_OCT_C 1.34e-02 3.84 1.18 6.49e-01 1.00e+00
5NOS1, NRXN1, MAB21L2, NAP1L5, ADM
 367
SMAD4_Q6 1.50e-02 4.53 1.17 6.49e-01 1.00e+00
4CALM1, NR2F1, MGAT4C, EEF1A1
 244
IRF_Q6 1.50e-02 4.53 1.17 6.49e-01 1.00e+00
4IFI44, HMCN1, TMEM108, RTN4
 244

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING 4.91e-06 132.55 20.77 3.67e-02 3.67e-02
3NOS1, CNR1, PLCB1
 9
GOBP_RETROGRADE_TRANS_SYNAPTIC_SIGNALING_BY_LIPID 1.54e-04 172.68 14.09 2.31e-01 1.00e+00
2CNR1, PLCB1
 5
GOBP_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL 3.22e-04 103.49 9.64 2.61e-01 1.00e+00
2IFIT1, STAT1
 7
GOBP_MESENCHYMAL_EPITHELIAL_CELL_SIGNALING 3.22e-04 103.49 9.64 2.61e-01 1.00e+00
2FGF10, HGF
 7
GOBP_REGULATION_OF_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS 3.22e-04 103.49 9.64 2.61e-01 1.00e+00
2FGF10, HGF
 7
GOBP_TRANS_SYNAPTIC_SIGNALING_BY_LIPID 3.22e-04 103.49 9.64 2.61e-01 1.00e+00
2CNR1, PLCB1
 7
GOBP_EMBRYONIC_BODY_MORPHOGENESIS 8.35e-04 57.69 5.91 4.16e-01 1.00e+00
2GREM2, MAB21L2
 11
GOBP_RESPONSE_TO_TYPE_I_INTERFERON 4.68e-05 14.46 4.38 1.17e-01 3.50e-01
5IFIT1, IFIT3, IFI27, STAT1, OAS3
 101
GOBP_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL 2.03e-03 34.68 3.75 5.84e-01 1.00e+00
2NOS1, CALM1
 17
GOBP_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE 8.97e-04 17.71 3.40 4.20e-01 1.00e+00
3FGF10, HGF, RTN4
 48
GOBP_AXONAL_FASCICULATION 2.54e-03 30.58 3.34 7.02e-01 1.00e+00
2CNR1, RTN4
 19
GOBP_NEGATIVE_REGULATION_OF_VIRAL_PROCESS 4.13e-04 12.78 3.27 2.61e-01 1.00e+00
4IFIT1, STAT1, EIF2AK2, OAS3
 89
GOBP_SEROTONIN_TRANSPORT 2.81e-03 28.89 3.17 7.02e-01 1.00e+00
2NOS1, CNR1
 20
GOBP_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS 2.81e-03 28.89 3.17 7.02e-01 1.00e+00
2FGF10, HGF
 20
GOBP_DEFENSE_RESPONSE_TO_VIRUS 6.21e-05 8.04 3.02 1.17e-01 4.64e-01
7IFIT1, IFIT3, IFI27, STAT1, EIF2AK2, PMAIP1, OAS3
 260
GOBP_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION 1.26e-03 15.63 3.02 5.05e-01 1.00e+00
3IFIT1, EIF2AK2, OAS3
 54
GOBP_RESPONSE_TO_INTERFERON_ALPHA 3.10e-03 27.37 3.01 7.20e-01 1.00e+00
2IFIT3, EIF2AK2
 21
GOBP_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT 6.17e-04 11.44 2.93 3.55e-01 1.00e+00
4NOS1, CALM1, CNR1, SNCG
 99
GOBP_PALLIUM_DEVELOPMENT 3.55e-04 9.20 2.81 2.61e-01 1.00e+00
5NPY, PLCB1, ARX, TMEM108, RTN4
 156
GOBP_RESPONSE_TO_VIRUS 6.28e-05 6.80 2.74 1.17e-01 4.70e-01
8IFIT1, IFI44, IFIT3, IFI27, STAT1, EIF2AK2, PMAIP1, OAS3
 358

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE10325_CD4_TCELL_VS_LUPUS_CD4_TCELL_DN 1.08e-11 21.10 9.88 5.29e-08 5.29e-08
12IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, PMAIP1, OAS3, HERC6, LGALS3BP, MMD
 199
GSE6269_HEALTHY_VS_FLU_INF_PBMC_DN 6.02e-10 20.40 8.94 5.86e-07 2.93e-06
10IFIT1, IFI44, IFIT3, IFI27, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP, ADM
 163
GSE42724_NAIVE_BCELL_VS_PLASMABLAST_UP 2.01e-10 18.95 8.62 2.87e-07 9.78e-07
11IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, RTN1, OAS3, HERC6, LGALS3BP
 197
GSE10325_MYELOID_VS_LUPUS_MYELOID_DN 2.35e-10 18.65 8.48 2.87e-07 1.15e-06
11IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, CALM1, HERC6, LGALS3BP, ADM
 200
GSE42021_TREG_VS_TCONV_PLN_UP 2.35e-10 18.65 8.48 2.87e-07 1.15e-06
11IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, PMAIP1, OAS3, HERC6, LGALS3BP
 200
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_ELK1_KO_DP_THYMOCYTES_UP 2.63e-09 17.36 7.62 1.31e-06 1.28e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, EIF2AK2, RTN1, OAS3, HERC6, LGALS3BP
 190
GSE21546_WT_VS_SAP1A_KO_DP_THYMOCYTES_UP 3.54e-09 16.80 7.38 1.31e-06 1.72e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 196
GSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_DN 3.72e-09 16.71 7.34 1.31e-06 1.81e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 197
GSE13485_DAY1_VS_DAY7_YF17D_VACCINE_PBMC_DN 3.90e-09 16.62 7.30 1.31e-06 1.90e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 198
GSE13485_DAY3_VS_DAY7_YF17D_VACCINE_PBMC_DN 3.90e-09 16.62 7.30 1.31e-06 1.90e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 198
GSE13485_PRE_VS_POST_YF17D_VACCINATION_PBMC_DN 3.90e-09 16.62 7.30 1.31e-06 1.90e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 198
GSE13484_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_DN 4.29e-09 16.45 7.22 1.31e-06 2.09e-05
10IFIT1, IFI44, IFIT3, STAT1, SPATS2L, EIF2AK2, CALM1, OAS3, HERC6, LGALS3BP
 200
GSE13485_CTRL_VS_DAY7_YF17D_VACCINE_PBMC_DN 4.29e-09 16.45 7.22 1.31e-06 2.09e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 200
GSE22886_CTRL_VS_LPS_24H_DC_DN 4.29e-09 16.45 7.22 1.31e-06 2.09e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, EIF2AK2, PMAIP1, OAS3, HERC6, LGALS3BP
 200
GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_UP 4.29e-09 16.45 7.22 1.31e-06 2.09e-05
10IFIT1, IFI44, IFIT3, STAT1, EIF2AK2, PKIB, PITX1, OAS3, HERC6, LGALS3BP
 200
GSE42021_TREG_PLN_VS_TREG_PRECURSORS_THYMUS_DN 4.29e-09 16.45 7.22 1.31e-06 2.09e-05
10IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 200
GSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP 1.81e-08 16.93 7.12 5.20e-06 8.83e-05
9IFIT1, IFI44, IFIT3, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6, LGALS3BP
 171
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_UP 4.27e-08 15.24 6.41 1.16e-05 2.08e-04
9IFIT1, IFIT3, IFI27, STAT1, EIF2AK2, MGAT4C, OAS3, HERC6, LGALS3BP
 189
GSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_DN 6.34e-08 14.52 6.11 1.35e-05 3.09e-04
9IFIT1, IFI44, IFIT3, STAT1, SPATS2L, EIF2AK2, PMAIP1, OAS3, HERC6
 198
GSE13485_CTRL_VS_DAY3_YF17D_VACCINE_PBMC_DN 6.62e-08 14.44 6.08 1.35e-05 3.22e-04
9IFIT1, IFI44, IFIT3, IFI27, STAT1, SPATS2L, EIF2AK2, OAS3, HERC6
 199

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
STAT1 6 Yes Known motif Monomer or homomultimer In vivo/Misc source None Structure PDB:1BF5 is Tyrosine phosphorylated
EIF2AK2 10 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NR2F1 26 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ARX 28 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PITX1 37 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CDC5L 53 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Compelling evidence for DNA binding (PMID: 11082045).
PLSCR1 58 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None PLSCR1 has been demonstrated to bind a GTAACCATGTGGA sequence in the IP3R1 promoter (PMID:16091359), mediated by a specific portion of the protein.
TWIST1 68 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Can form both homodimers and heterodimers with TCF3 (PMID: 16502419).
TBX3 75 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HDAC9 80 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor
DDX58 84 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
YBX1 87 Yes Known motif Monomer or homomultimer High-throughput in vitro None Might also bind RNA
HMBOX1 102 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PRRX2 105 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
AFF3 106 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 8555498) only says that In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose - thats more consistent with nonspecific DNA binding. The key issue is whether the Transcription factor AF4/FMR2 (IPR007797) domain really is sequence specific. Most of the work has been done on the one Drosophila ortholog, lilliuputian. I see no evidence of DNA binding. Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 261712
SCOC 110 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Not a proper bZIP; contains only a small leucine zipper region but lacks the DNA-interfacing basic part.
BNC1 123 Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None
MBNL2 138 Yes Likely to be sequence specific TF Monomer or homomultimer High-throughput in vitro None Has methylated and unmethylated HT-SELEX motifs, despite this family largely binding RNA exclusively (PMID: 28473536 )
EDF1 152 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-factor that binds DNA indirectly through interactions with TFs (PMID:12040021)
TEAD1 177 Yes Known motif Monomer or homomultimer High-throughput in vitro None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T200_AATAGAGTCGCAATTG-1 Neurons:adrenal_medulla_cell_line 0.13 724.10
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.23
T200_GTGTTCCGTAGGTGCA-1 Neurons:adrenal_medulla_cell_line 0.13 719.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:skin_fibroblast-derived: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25
T200_TTGTTTGAGTTACGTC-1 Neurons:adrenal_medulla_cell_line 0.13 713.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.26, Embryonic_stem_cells: 0.26, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_2lox-17: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25
T200_AGGCTGCTCTGGCCAG-1 Neurons:adrenal_medulla_cell_line 0.14 697.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-22: 0.26
T200_GGCTGTGTCGATACGT-1 Neurons:adrenal_medulla_cell_line 0.14 650.91
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:Schwann_cell: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.24, Smooth_muscle_cells:bronchial: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, MSC: 0.24
T200_GGGAAGTCACAAACGG-1 Neurons:adrenal_medulla_cell_line 0.14 639.52
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.29, Embryonic_stem_cells: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26, Fibroblasts:breast: 0.26, MSC: 0.26, Smooth_muscle_cells:umbilical_vein: 0.26, iPS_cells:PDB_2lox-5: 0.26
T200_GTGGTTATCATCGCTC-1 Neurons:adrenal_medulla_cell_line 0.21 619.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-21: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_2lox-17: 0.33
T200_CGGTCAGTCAACGTGT-1 Neurons:adrenal_medulla_cell_line 0.14 609.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_2lox-17: 0.24, iPS_cells:PDB_2lox-5: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_2lox-21: 0.24
T200_ATTACCTTCGAAGCCC-1 Neurons:adrenal_medulla_cell_line 0.20 608.30
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neuroepithelial_cell:ESC-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.27, Embryonic_stem_cells: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_2lox-22: 0.26
T200_TCCGAAACAGCTACCG-1 Neurons:adrenal_medulla_cell_line 0.14 606.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26
T200_CTGTACCGTATAGCTC-1 Neurons:adrenal_medulla_cell_line 0.17 549.75
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.27, Embryonic_stem_cells: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-22: 0.26
T200_AATGGAATCTTCTGTA-1 Neurons:adrenal_medulla_cell_line 0.16 544.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neuroepithelial_cell:ESC-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, Embryonic_stem_cells: 0.26
T200_CCCATTGTCGAGAGAC-1 Neurons:adrenal_medulla_cell_line 0.14 543.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.27, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_2lox-5: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:iPS:minicircle-derived: 0.25, iPS_cells:skin_fibroblast-derived: 0.25
T200_GCGGAAAAGAAACTCA-1 Neurons:adrenal_medulla_cell_line 0.15 538.11
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22
T200_AGCTCAATCGCTCTAC-1 Neurons:adrenal_medulla_cell_line 0.17 500.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neuroepithelial_cell:ESC-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_2lox-21: 0.27
T200_GACCAATCATCAGCGC-1 Neurons:adrenal_medulla_cell_line 0.09 494.15
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.27, Fibroblasts:breast: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.27, Neurons:adrenal_medulla_cell_line: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Smooth_muscle_cells:bronchial: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:adipose_stem_cells: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.26, Chondrocytes:MSC-derived: 0.26
T200_CACTGAAGTTCCCACT-1 Neurons:adrenal_medulla_cell_line 0.17 487.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26, iPS_cells:PDB_2lox-22: 0.26
T200_TCATGCCTCACTTTGT-1 Neurons:adrenal_medulla_cell_line 0.14 475.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:skin_fibroblast-derived: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:PDB_2lox-5: 0.25
T200_TAACCAGTCTCCTACG-1 Neurons:adrenal_medulla_cell_line 0.18 474.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_2lox-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24
T200_GCCAGTGGTGGTCCCA-1 Neurons:adrenal_medulla_cell_line 0.14 464.77
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, Embryonic_stem_cells: 0.23
T200_GCTCAAATCATGAGAA-1 Neurons:adrenal_medulla_cell_line 0.16 463.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-22: 0.25, Embryonic_stem_cells: 0.25
T200_CCATAAGGTACTAACC-1 Neurons:adrenal_medulla_cell_line 0.17 460.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_2lox-21: 0.26
T200_GTTACCCAGCATTGAA-1 Neurons:adrenal_medulla_cell_line 0.16 457.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.27, Embryonic_stem_cells: 0.27, iPS_cells:PDB_2lox-22: 0.27
T200_TCTATACCAGGTCTCG-1 Neurons:adrenal_medulla_cell_line 0.13 454.99
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:PDB_2lox-5: 0.24, iPS_cells:PDB_2lox-21: 0.24
T200_TACTGCCAGGGAGGAC-1 Neurons:adrenal_medulla_cell_line 0.17 445.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23
T200_CCGATGGCAGTTTCAG-1 Neurons:adrenal_medulla_cell_line 0.14 437.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:skin_fibroblast-derived: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:iPS:minicircle-derived: 0.26, Embryonic_stem_cells: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.25
T200_GATCACAGTGACTGTT-1 Neurons:adrenal_medulla_cell_line 0.14 434.81
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:PDB_2lox-22: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-5: 0.25
T200_GTATTTCAGGCTCTAT-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.15 428.08
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, DC:monocyte-derived:LPS: 0.38, Macrophage:monocyte-derived:IFNa: 0.38, DC:monocyte-derived:AEC-conditioned: 0.38, DC:monocyte-derived:Poly(IC): 0.38, Macrophage:monocyte-derived:M-CSF: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, Macrophage:monocyte-derived:S._aureus: 0.38, DC:monocyte-derived:Galectin-1: 0.38
T200_CTCTCAGAGCCACCGT-1 Neurons:adrenal_medulla_cell_line 0.19 408.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-21: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31
T200_TTGTTCAGTGCAAGAC-1 Neurons:adrenal_medulla_cell_line 0.19 407.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, Embryonic_stem_cells: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_2lox-17: 0.34, iPS_cells:PDB_2lox-21: 0.34
T200_TCTTGCGAGAAACCCG-1 Fibroblasts:foreskin 0.13 406.80
Raw ScoresMSC: 0.35, Neuroepithelial_cell:ESC-derived: 0.34, Fibroblasts:foreskin: 0.34, Neurons:Schwann_cell: 0.34, Fibroblasts:breast: 0.34, iPS_cells:CRL2097_foreskin: 0.33, Tissue_stem_cells:BM_MSC: 0.33, Smooth_muscle_cells:vascular: 0.33, Neurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33
T200_TATTGGGCACGACGAA-1 Neurons:adrenal_medulla_cell_line 0.16 403.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-17: 0.26
T200_ATCAGGTAGACTTAAG-1 Neurons:adrenal_medulla_cell_line 0.15 402.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, Embryonic_stem_cells: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26
T200_ACGGTCGCACATTCTT-1 Neurons:adrenal_medulla_cell_line 0.12 399.30
Raw ScoresFibroblasts:breast: 0.32, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Smooth_muscle_cells:bronchial: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, iPS_cells:CRL2097_foreskin: 0.32, Smooth_muscle_cells:vascular: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, iPS_cells:adipose_stem_cells: 0.31, MSC: 0.31, Chondrocytes:MSC-derived: 0.31
T200_AGGGTCCCAGGAACCA-1 Neurons:adrenal_medulla_cell_line 0.14 392.44
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neuroepithelial_cell:ESC-derived: 0.3, Embryonic_stem_cells: 0.27, Tissue_stem_cells:dental_pulp: 0.26, Fibroblasts:breast: 0.26, Smooth_muscle_cells:umbilical_vein: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26
T200_TCCTCCCAGCCTCATA-1 Neurons:adrenal_medulla_cell_line 0.17 385.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_2lox-22: 0.27, Embryonic_stem_cells: 0.27
T200_CCTTGTGAGTTACGGG-1 DC:monocyte-derived:AEC-conditioned 0.12 383.02
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, Macrophage:monocyte-derived:S._aureus: 0.36, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.35, DC:monocyte-derived:anti-DC-SIGN_2h: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Macrophage:Alveolar:B._anthacis_spores: 0.35, DC:monocyte-derived:LPS: 0.35, Macrophage:monocyte-derived:M-CSF: 0.35, Macrophage:Alveolar: 0.35
T200_GAACTGTAGTACAACA-1 Neurons:adrenal_medulla_cell_line 0.16 382.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neuroepithelial_cell:ESC-derived: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:skin_fibroblast-derived: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_2lox-22: 0.28
T200_GTAGAGGGTGATTGGG-1 Neurons:adrenal_medulla_cell_line 0.14 380.96
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-17: 0.27
T200_TCATTACAGGGAGGAC-1 Neurons:adrenal_medulla_cell_line 0.18 380.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27
T200_CATGAGTGTTACACAC-1 Neurons:adrenal_medulla_cell_line 0.14 380.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.28, iPS_cells:PDB_2lox-22: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27
T200_ATCTTCACACAGCCTG-1 Neurons:adrenal_medulla_cell_line 0.15 367.82
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.28, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_2lox-21: 0.28
T200_CCCTAACGTTGTGTTG-1 Neurons:adrenal_medulla_cell_line 0.14 366.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, Embryonic_stem_cells: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26
T200_TGGGAGACACGACGAA-1 Neurons:adrenal_medulla_cell_line 0.14 364.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.28, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_2lox-22: 0.25
T200_GATAGAAAGACATCCT-1 Neurons:adrenal_medulla_cell_line 0.16 362.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24
T200_CAATCGACAAGGGTCA-1 Neurons:adrenal_medulla_cell_line 0.15 359.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.29, iPS_cells:PDB_2lox-17: 0.29
T200_CCGGTAGTCATAGACC-1 Macrophage:monocyte-derived:S._aureus 0.09 357.63
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.3, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.3, Macrophage:monocyte-derived:IFNa: 0.3, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.3, DC:monocyte-derived:LPS: 0.3, Monocyte:CD16-: 0.3, DC:monocyte-derived:anti-DC-SIGN_2h: 0.3, DC:monocyte-derived:Galectin-1: 0.3, DC:monocyte-derived:AEC-conditioned: 0.3, Macrophage:monocyte-derived:M-CSF/IFNg: 0.3
T200_GCACTAATCACATCAG-1 Neurons:adrenal_medulla_cell_line 0.13 356.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, Fibroblasts:breast: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23
T200_CTACCCAGTTTGGAAA-1 Neurons:adrenal_medulla_cell_line 0.15 356.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_2lox-21: 0.23
T200_CACAGGCCAACAAGTA-1 Neurons:adrenal_medulla_cell_line 0.15 344.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_2lox-21: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-17: 0.26


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.51e-05
Mean rank of genes in gene set: 2499.19
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NAP1L5 0.0040741 42 GTEx DepMap Descartes 1.66 135.46
SYN2 0.0032153 69 GTEx DepMap Descartes 0.27 11.04
CELF4 0.0029256 89 GTEx DepMap Descartes 3.47 133.65
SCG5 0.0028867 91 GTEx DepMap Descartes 5.31 644.91
CACNA2D1 0.0023589 135 GTEx DepMap Descartes 1.12 22.99
SCG3 0.0020511 180 GTEx DepMap Descartes 4.14 197.86
LGR5 0.0014562 323 GTEx DepMap Descartes 0.10 3.12
SNAP25 0.0008626 741 GTEx DepMap Descartes 1.58 104.68
GNAS 0.0006215 1112 GTEx DepMap Descartes 32.91 1225.20
PTPRN 0.0004796 1434 GTEx DepMap Descartes 0.65 19.78
PCLO 0.0003679 1735 GTEx DepMap Descartes 0.97 7.20
ADCYAP1R1 0.0001980 2502 GTEx DepMap Descartes 0.16 3.42
CXCL14 0.0001039 3110 GTEx DepMap Descartes 0.02 1.97
PPFIA2 0.0000639 3438 GTEx DepMap Descartes 0.21 5.97
SLCO3A1 -0.0013168 12450 GTEx DepMap Descartes 0.40 10.54
C1QL1 -0.0018901 12536 GTEx DepMap Descartes 0.27 26.61


Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.06e-03
Mean rank of genes in gene set: 274
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NPY 0.0062200 15 GTEx DepMap Descartes 54.84 11736.49
GAP43 0.0021549 162 GTEx DepMap Descartes 5.78 449.57
BCL2 0.0009714 645 GTEx DepMap Descartes 0.80 16.62


IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.50e-03
Mean rank of genes in gene set: 2044.4
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IFIT1 0.0119898 1 GTEx DepMap Descartes 3.74 125.06
IFIT3 0.0109563 3 GTEx DepMap Descartes 2.88 178.74
IFIT2 0.0023667 134 GTEx DepMap Descartes 0.52 21.74
ISG15 0.0018666 207 GTEx DepMap Descartes 7.97 1510.77
ISG20 -0.0004166 9877 GTEx DepMap Descartes 0.15 3.27




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.67e-02
Mean rank of genes in gene set: 5950.58
Median rank of genes in gene set: 5457
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FBXO8 0.0062642 14 GTEx DepMap Descartes 1.39 106.09
NPY 0.0062200 15 GTEx DepMap Descartes 54.84 11736.49
NNAT 0.0051197 22 GTEx DepMap Descartes 7.58 911.70
RTN1 0.0050951 23 GTEx DepMap Descartes 16.39 763.13
TMEM108 0.0041530 39 GTEx DepMap Descartes 0.83 25.59
NAP1L5 0.0040741 42 GTEx DepMap Descartes 1.66 135.46
MMD 0.0038208 47 GTEx DepMap Descartes 2.45 140.40
TUBB2A 0.0036454 52 GTEx DepMap Descartes 8.99 803.41
PRSS12 0.0034987 57 GTEx DepMap Descartes 0.99 32.82
CEP44 0.0032119 70 GTEx DepMap Descartes 1.61 58.25
RPS6KA2 0.0030018 85 GTEx DepMap Descartes 0.67 16.97
RBMS3 0.0029939 86 GTEx DepMap Descartes 4.12 74.73
MAP2 0.0028708 92 GTEx DepMap Descartes 3.16 47.59
SCN3A 0.0023221 136 GTEx DepMap Descartes 1.15 19.40
OLFM1 0.0023203 139 GTEx DepMap Descartes 1.49 83.10
NRSN1 0.0021778 155 GTEx DepMap Descartes 1.66 106.27
PKIA 0.0021587 161 GTEx DepMap Descartes 1.86 71.09
GAP43 0.0021549 162 GTEx DepMap Descartes 5.78 449.57
OLA1 0.0021071 169 GTEx DepMap Descartes 4.12 138.30
FKBP1B 0.0021063 171 GTEx DepMap Descartes 1.38 130.86
DPYSL2 0.0020939 175 GTEx DepMap Descartes 3.76 117.18
SCG3 0.0020511 180 GTEx DepMap Descartes 4.14 197.86
FAM171B 0.0020057 181 GTEx DepMap Descartes 1.02 27.36
SEC11C 0.0020037 182 GTEx DepMap Descartes 3.26 229.05
ELAVL4 0.0019962 183 GTEx DepMap Descartes 9.24 345.12
MYRIP 0.0019057 200 GTEx DepMap Descartes 0.11 3.02
CCNI 0.0018666 208 GTEx DepMap Descartes 21.93 1167.22
INA 0.0018604 211 GTEx DepMap Descartes 2.71 123.84
EIF1B 0.0018336 220 GTEx DepMap Descartes 5.45 845.01
ELAVL2 0.0018003 226 GTEx DepMap Descartes 2.01 75.60


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 7387.25
Median rank of genes in gene set: 8052
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
STAT1 0.0083173 6 GTEx DepMap Descartes 3.98 141.58
PLSCR1 0.0034636 58 GTEx DepMap Descartes 1.22 92.00
ATP1B1 0.0031777 72 GTEx DepMap Descartes 3.72 220.56
IGFBP5 0.0027284 100 GTEx DepMap Descartes 4.70 123.34
PTN 0.0019916 186 GTEx DepMap Descartes 1.25 124.37
CRABP2 0.0019325 195 GTEx DepMap Descartes 0.49 69.89
FGFR1 0.0019249 198 GTEx DepMap Descartes 0.52 12.19
DKK3 0.0016123 269 GTEx DepMap Descartes 0.60 9.96
COL11A1 0.0015231 295 GTEx DepMap Descartes 0.17 3.66
BMP5 0.0014576 321 GTEx DepMap Descartes 0.03 0.98
PDE3A 0.0013906 357 GTEx DepMap Descartes 0.25 4.87
BNC2 0.0013454 380 GTEx DepMap Descartes 0.09 0.96
CRTAP 0.0013398 385 GTEx DepMap Descartes 0.76 15.97
PPIB 0.0012015 456 GTEx DepMap Descartes 6.91 844.81
SVIL 0.0011276 507 GTEx DepMap Descartes 0.27 4.89
WNT5A 0.0010581 553 GTEx DepMap Descartes 0.05 1.13
SCRG1 0.0010468 565 GTEx DepMap Descartes 0.40 15.39
EGR3 0.0010302 574 GTEx DepMap Descartes 0.69 22.40
DMD 0.0010291 576 GTEx DepMap Descartes 0.39 4.39
KDM5B 0.0009823 628 GTEx DepMap Descartes 1.18 18.73
STAT3 0.0009739 642 GTEx DepMap Descartes 1.75 52.17
APP 0.0009397 670 GTEx DepMap Descartes 1.81 78.11
GPC6 0.0008748 729 GTEx DepMap Descartes 0.19 3.95
IL6ST 0.0008215 790 GTEx DepMap Descartes 0.44 7.09
ATXN1 0.0007971 818 GTEx DepMap Descartes 0.49 7.35
EXTL2 0.0007926 826 GTEx DepMap Descartes 0.53 24.76
ATP2B4 0.0007762 849 GTEx DepMap Descartes 0.25 4.40
ARMCX2 0.0007538 881 GTEx DepMap Descartes 0.41 20.85
MYL12B 0.0007527 884 GTEx DepMap Descartes 4.29 501.65
GNAI1 0.0007494 889 GTEx DepMap Descartes 0.73 11.30


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.47e-01
Mean rank of genes in gene set: 5862.42
Median rank of genes in gene set: 5701.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GSTA4 0.0018219 223 GTEx DepMap Descartes 2.11 184.77
SH3BP5 0.0015813 279 GTEx DepMap Descartes 1.09 48.11
TM7SF2 0.0011521 490 GTEx DepMap Descartes 0.81 59.02
SGCZ 0.0010864 535 GTEx DepMap Descartes 0.06 1.18
MSMO1 0.0006002 1160 GTEx DepMap Descartes 0.52 33.74
POR 0.0005612 1236 GTEx DepMap Descartes 0.52 29.99
CLU 0.0004922 1394 GTEx DepMap Descartes 1.82 104.67
GRAMD1B 0.0004139 1589 GTEx DepMap Descartes 0.12 2.30
PEG3 0.0003098 1961 GTEx DepMap Descartes 0.54 NA
PDE10A 0.0003028 1996 GTEx DepMap Descartes 0.18 3.27
JAKMIP2 0.0001876 2556 GTEx DepMap Descartes 0.55 8.93
SH3PXD2B 0.0000640 3436 GTEx DepMap Descartes 0.10 1.85
HMGCS1 0.0000350 3709 GTEx DepMap Descartes 0.35 9.15
HMGCR 0.0000317 3744 GTEx DepMap Descartes 0.36 11.67
DHCR7 -0.0000008 4112 GTEx DepMap Descartes 0.15 8.14
FDXR -0.0000480 4757 GTEx DepMap Descartes 0.20 11.30
INHA -0.0000513 4809 GTEx DepMap Descartes 0.01 0.45
BAIAP2L1 -0.0000789 5236 GTEx DepMap Descartes 0.01 0.44
FREM2 -0.0001357 6167 GTEx DepMap Descartes 0.00 0.01
STAR -0.0001374 6192 GTEx DepMap Descartes 0.02 0.82
ERN1 -0.0001496 6396 GTEx DepMap Descartes 0.11 2.27
FDPS -0.0001893 6964 GTEx DepMap Descartes 1.26 85.27
LDLR -0.0002234 7465 GTEx DepMap Descartes 0.06 1.36
SCAP -0.0002390 7670 GTEx DepMap Descartes 0.27 8.95
DHCR24 -0.0003022 8508 GTEx DepMap Descartes 0.09 1.93
CYB5B -0.0004006 9711 GTEx DepMap Descartes 0.37 11.84
NPC1 -0.0004496 10190 GTEx DepMap Descartes 0.05 1.83
SLC16A9 -0.0004503 10195 GTEx DepMap Descartes 0.10 3.20
IGF1R -0.0004511 10200 GTEx DepMap Descartes 0.37 4.33
FDX1 -0.0004701 10350 GTEx DepMap Descartes 0.62 27.74


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.47e-01
Mean rank of genes in gene set: 5887.98
Median rank of genes in gene set: 4168
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NPY 0.0062200 15 GTEx DepMap Descartes 54.84 11736.49
MAB21L2 0.0048588 29 GTEx DepMap Descartes 3.11 188.54
TUBB2A 0.0036454 52 GTEx DepMap Descartes 8.99 803.41
RYR2 0.0022885 143 GTEx DepMap Descartes 0.41 3.70
GAP43 0.0021549 162 GTEx DepMap Descartes 5.78 449.57
MAB21L1 0.0019871 188 GTEx DepMap Descartes 2.84 154.45
ELAVL2 0.0018003 226 GTEx DepMap Descartes 2.01 75.60
TUBB2B 0.0016726 256 GTEx DepMap Descartes 30.78 2424.10
TUBA1A 0.0013997 352 GTEx DepMap Descartes 46.96 3569.15
EYA1 0.0012056 451 GTEx DepMap Descartes 0.35 13.20
MAP1B 0.0009455 662 GTEx DepMap Descartes 13.78 170.38
SLC44A5 0.0009437 663 GTEx DepMap Descartes 0.14 4.61
REEP1 0.0009075 702 GTEx DepMap Descartes 0.75 27.63
SYNPO2 0.0008882 716 GTEx DepMap Descartes 0.63 6.40
BASP1 0.0008408 768 GTEx DepMap Descartes 13.87 1134.98
MARCH11 0.0006678 1023 GTEx DepMap Descartes 4.71 NA
RPH3A 0.0004849 1421 GTEx DepMap Descartes 0.14 4.06
EPHA6 0.0002680 2147 GTEx DepMap Descartes 0.06 2.00
MLLT11 0.0002387 2274 GTEx DepMap Descartes 8.29 492.00
CNKSR2 0.0000420 3636 GTEx DepMap Descartes 0.19 3.65
TMEFF2 -0.0000054 4168 GTEx DepMap Descartes 0.41 19.27
PTCHD1 -0.0000131 4262 GTEx DepMap Descartes 0.13 1.73
GAL -0.0002483 7784 GTEx DepMap Descartes 1.83 371.35
CNTFR -0.0003069 8577 GTEx DepMap Descartes 0.76 58.95
HS3ST5 -0.0003500 9127 GTEx DepMap Descartes 0.03 1.26
ANKFN1 -0.0004894 10523 GTEx DepMap Descartes 0.01 0.15
ALK -0.0004980 10577 GTEx DepMap Descartes 0.04 1.09
GREM1 -0.0005973 11234 GTEx DepMap Descartes 0.00 0.00
KCNB2 -0.0006958 11631 GTEx DepMap Descartes 0.07 3.07
STMN2 -0.0007238 11724 GTEx DepMap Descartes 22.60 1805.85


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.07e-01
Mean rank of genes in gene set: 6595.13
Median rank of genes in gene set: 7727.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MYRIP 0.0019057 200 GTEx DepMap Descartes 0.11 3.02
ARHGAP29 0.0016032 271 GTEx DepMap Descartes 0.71 11.88
CHRM3 0.0013316 387 GTEx DepMap Descartes 0.55 9.45
RAMP2 0.0007993 814 GTEx DepMap Descartes 1.92 328.74
GALNT15 0.0004101 1598 GTEx DepMap Descartes 0.03 NA
NOTCH4 0.0003897 1665 GTEx DepMap Descartes 0.22 4.90
EHD3 0.0002675 2148 GTEx DepMap Descartes 0.05 1.59
F8 0.0002419 2258 GTEx DepMap Descartes 0.03 0.55
CLDN5 0.0000446 3608 GTEx DepMap Descartes 0.15 8.22
ID1 0.0000252 3806 GTEx DepMap Descartes 0.28 35.13
SHANK3 0.0000104 3974 GTEx DepMap Descartes 0.04 0.78
NR5A2 -0.0000280 4460 GTEx DepMap Descartes 0.00 0.05
TEK -0.0001645 6624 GTEx DepMap Descartes 0.00 0.02
HYAL2 -0.0001730 6736 GTEx DepMap Descartes 0.69 24.90
SHE -0.0002102 7268 GTEx DepMap Descartes 0.01 0.13
RASIP1 -0.0002207 7424 GTEx DepMap Descartes 0.01 0.41
KANK3 -0.0002295 7549 GTEx DepMap Descartes 0.01 0.65
ESM1 -0.0002349 7611 GTEx DepMap Descartes 0.01 0.27
ROBO4 -0.0002422 7708 GTEx DepMap Descartes 0.02 0.39
NPR1 -0.0002452 7747 GTEx DepMap Descartes 0.00 0.04
CDH5 -0.0002529 7854 GTEx DepMap Descartes 0.02 0.49
CRHBP -0.0002555 7886 GTEx DepMap Descartes 0.01 0.89
KDR -0.0002615 7978 GTEx DepMap Descartes 0.02 0.48
BTNL9 -0.0002772 8186 GTEx DepMap Descartes 0.00 0.02
CEACAM1 -0.0002860 8293 GTEx DepMap Descartes 0.00 0.11
FLT4 -0.0002890 8326 GTEx DepMap Descartes 0.01 0.10
PTPRB -0.0002913 8363 GTEx DepMap Descartes 0.02 0.16
CALCRL -0.0003204 8757 GTEx DepMap Descartes 0.02 0.28
MMRN2 -0.0003243 8807 GTEx DepMap Descartes 0.02 0.40
PLVAP -0.0003360 8965 GTEx DepMap Descartes 0.07 3.20


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.98e-01
Mean rank of genes in gene set: 6409.84
Median rank of genes in gene set: 6182
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCOLCE 0.0018892 203 GTEx DepMap Descartes 2.95 284.24
CLDN11 0.0013128 402 GTEx DepMap Descartes 0.16 9.13
FREM1 0.0007934 823 GTEx DepMap Descartes 0.05 0.64
DKK2 0.0007900 829 GTEx DepMap Descartes 0.03 1.36
ADAMTSL3 0.0002885 2040 GTEx DepMap Descartes 0.02 0.31
EDNRA 0.0002502 2217 GTEx DepMap Descartes 0.08 2.41
PRICKLE1 0.0002333 2297 GTEx DepMap Descartes 0.31 7.64
LRRC17 0.0001541 2761 GTEx DepMap Descartes 0.03 2.18
LAMC3 0.0000495 3568 GTEx DepMap Descartes 0.01 0.10
GLI2 -0.0000094 4211 GTEx DepMap Descartes 0.00 0.06
PCDH18 -0.0000480 4756 GTEx DepMap Descartes 0.04 1.22
RSPO3 -0.0000617 4996 GTEx DepMap Descartes 0.00 NA
GAS2 -0.0000656 5056 GTEx DepMap Descartes 0.01 0.67
CCDC80 -0.0000873 5377 GTEx DepMap Descartes 0.06 0.78
ITGA11 -0.0000951 5505 GTEx DepMap Descartes 0.00 0.10
POSTN -0.0001085 5710 GTEx DepMap Descartes 0.04 1.57
IGFBP3 -0.0001142 5810 GTEx DepMap Descartes 0.02 1.01
ISLR -0.0001191 5893 GTEx DepMap Descartes 0.01 0.94
SFRP2 -0.0001215 5940 GTEx DepMap Descartes 0.00 0.07
BICC1 -0.0001242 5981 GTEx DepMap Descartes 0.03 0.71
COL6A3 -0.0001325 6107 GTEx DepMap Descartes 0.16 2.17
LOX -0.0001339 6134 GTEx DepMap Descartes 0.00 0.06
C7 -0.0001400 6230 GTEx DepMap Descartes 0.02 0.47
SCARA5 -0.0001539 6461 GTEx DepMap Descartes 0.00 0.00
PDGFRA -0.0001707 6706 GTEx DepMap Descartes 0.23 5.67
COL12A1 -0.0002016 7147 GTEx DepMap Descartes 0.04 0.55
PAMR1 -0.0002086 7248 GTEx DepMap Descartes 0.01 0.37
ABCA6 -0.0002185 7394 GTEx DepMap Descartes 0.01 0.24
COL27A1 -0.0002345 7607 GTEx DepMap Descartes 0.01 0.07
ACTA2 -0.0002612 7972 GTEx DepMap Descartes 0.50 36.86


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.01e-01
Mean rank of genes in gene set: 5969
Median rank of genes in gene set: 6622.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MGAT4C 0.0049011 27 GTEx DepMap Descartes 0.90 5.63
NTNG1 0.0030173 83 GTEx DepMap Descartes 0.76 23.89
PCSK1N 0.0021604 160 GTEx DepMap Descartes 11.96 1733.34
GRID2 0.0019947 184 GTEx DepMap Descartes 0.34 9.14
SPOCK3 0.0011203 516 GTEx DepMap Descartes 0.15 7.03
SLC35F3 0.0007290 916 GTEx DepMap Descartes 0.03 1.30
ARC 0.0006144 1124 GTEx DepMap Descartes 1.95 98.35
SORCS3 0.0005564 1251 GTEx DepMap Descartes 0.09 2.80
CHGB 0.0005352 1306 GTEx DepMap Descartes 5.71 397.12
PCSK2 0.0001572 2743 GTEx DepMap Descartes 0.04 1.42
GRM7 0.0001361 2871 GTEx DepMap Descartes 0.03 0.98
KSR2 0.0001157 3017 GTEx DepMap Descartes 0.10 0.92
CCSER1 0.0001022 3118 GTEx DepMap Descartes 0.12 NA
UNC80 0.0000311 3751 GTEx DepMap Descartes 0.29 3.04
HTATSF1 0.0000074 4018 GTEx DepMap Descartes 1.19 56.56
PENK 0.0000062 4032 GTEx DepMap Descartes 0.00 0.40
CDH12 -0.0000186 4338 GTEx DepMap Descartes 0.03 1.22
CDH18 -0.0001252 5995 GTEx DepMap Descartes 0.03 0.94
FAM155A -0.0001419 6265 GTEx DepMap Descartes 0.31 4.83
TENM1 -0.0001907 6980 GTEx DepMap Descartes 0.06 NA
CNTN3 -0.0001932 7029 GTEx DepMap Descartes 0.00 0.13
PACRG -0.0002136 7313 GTEx DepMap Descartes 0.09 7.84
ST18 -0.0002299 7555 GTEx DepMap Descartes 0.00 0.00
KCTD16 -0.0002624 7991 GTEx DepMap Descartes 0.46 4.98
ROBO1 -0.0002713 8112 GTEx DepMap Descartes 0.23 4.11
TBX20 -0.0002753 8163 GTEx DepMap Descartes 0.01 1.17
EML6 -0.0002762 8173 GTEx DepMap Descartes 0.03 0.43
SLC24A2 -0.0003019 8504 GTEx DepMap Descartes 0.00 0.06
LAMA3 -0.0003686 9328 GTEx DepMap Descartes 0.00 0.00
AGBL4 -0.0003701 9347 GTEx DepMap Descartes 0.04 1.64


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.64e-01
Mean rank of genes in gene set: 7013.1
Median rank of genes in gene set: 6498
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SNCA 0.0005532 1261 GTEx DepMap Descartes 0.67 32.02
GCLC 0.0003281 1890 GTEx DepMap Descartes 0.21 8.08
ANK1 0.0001389 2855 GTEx DepMap Descartes 0.11 1.71
TRAK2 0.0001038 3111 GTEx DepMap Descartes 0.17 4.05
CPOX 0.0000908 3216 GTEx DepMap Descartes 0.07 3.57
RGS6 0.0000305 3764 GTEx DepMap Descartes 0.00 0.09
RHD -0.0000160 4299 GTEx DepMap Descartes 0.00 0.00
SLC25A21 -0.0000430 4683 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000526 4836 GTEx DepMap Descartes 0.00 0.07
SPTB -0.0000626 5011 GTEx DepMap Descartes 0.07 1.18
ALAS2 -0.0000869 5372 GTEx DepMap Descartes 0.00 0.00
TSPAN5 -0.0001082 5703 GTEx DepMap Descartes 0.75 27.06
XPO7 -0.0001451 6328 GTEx DepMap Descartes 0.22 6.03
TMCC2 -0.0001557 6496 GTEx DepMap Descartes 0.03 1.28
ABCB10 -0.0001558 6498 GTEx DepMap Descartes 0.05 1.91
CAT -0.0001784 6810 GTEx DepMap Descartes 0.31 18.56
MICAL2 -0.0002466 7766 GTEx DepMap Descartes 0.02 0.31
SELENBP1 -0.0002827 8243 GTEx DepMap Descartes 0.01 0.36
MARCH3 -0.0002972 8445 GTEx DepMap Descartes 0.03 NA
FECH -0.0003285 8867 GTEx DepMap Descartes 0.09 1.53
RAPGEF2 -0.0003700 9345 GTEx DepMap Descartes 0.29 5.14
BLVRB -0.0003703 9350 GTEx DepMap Descartes 0.55 41.81
DENND4A -0.0004055 9762 GTEx DepMap Descartes 0.20 3.52
TFR2 -0.0004099 9811 GTEx DepMap Descartes 0.06 2.65
SPECC1 -0.0006577 11479 GTEx DepMap Descartes 0.03 0.36
GYPC -0.0006717 11535 GTEx DepMap Descartes 0.23 15.68
SOX6 -0.0007868 11890 GTEx DepMap Descartes 0.02 0.31
EPB41 -0.0011033 12342 GTEx DepMap Descartes 0.31 6.94
SLC25A37 -0.0012245 12412 GTEx DepMap Descartes 0.30 8.26
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9417.53
Median rank of genes in gene set: 10712.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FMN1 0.0008489 757 GTEx DepMap Descartes 0.35 4.15
HRH1 0.0002176 2383 GTEx DepMap Descartes 0.05 1.65
MSR1 0.0001244 2954 GTEx DepMap Descartes 0.26 8.94
SLC9A9 -0.0000278 4455 GTEx DepMap Descartes 0.05 1.73
IFNGR1 -0.0000587 4945 GTEx DepMap Descartes 0.49 27.31
WWP1 -0.0000832 5304 GTEx DepMap Descartes 0.16 4.87
PTPRE -0.0000863 5363 GTEx DepMap Descartes 0.18 4.05
RGL1 -0.0002113 7284 GTEx DepMap Descartes 0.07 1.54
SFMBT2 -0.0002598 7945 GTEx DepMap Descartes 0.04 0.68
FGD2 -0.0002683 8073 GTEx DepMap Descartes 0.02 0.31
SLC1A3 -0.0002992 8475 GTEx DepMap Descartes 0.04 1.42
ATP8B4 -0.0003093 8614 GTEx DepMap Descartes 0.01 0.10
MERTK -0.0003469 9090 GTEx DepMap Descartes 0.06 1.50
ABCA1 -0.0003591 9225 GTEx DepMap Descartes 0.18 2.33
MARCH1 -0.0003821 9508 GTEx DepMap Descartes 0.13 NA
CPVL -0.0004317 10018 GTEx DepMap Descartes 0.27 10.45
SPP1 -0.0004992 10591 GTEx DepMap Descartes 0.81 59.89
HCK -0.0005047 10630 GTEx DepMap Descartes 0.05 2.29
CST3 -0.0005075 10655 GTEx DepMap Descartes 3.99 155.84
LGMN -0.0005213 10770 GTEx DepMap Descartes 1.03 50.06
CD74 -0.0005800 11144 GTEx DepMap Descartes 2.88 93.76
CTSB -0.0005865 11173 GTEx DepMap Descartes 1.88 56.28
AXL -0.0006405 11416 GTEx DepMap Descartes 0.11 2.38
RBPJ -0.0006452 11443 GTEx DepMap Descartes 1.17 28.66
CSF1R -0.0006560 11476 GTEx DepMap Descartes 0.10 2.96
ADAP2 -0.0006657 11514 GTEx DepMap Descartes 0.13 5.18
CD163 -0.0006852 11588 GTEx DepMap Descartes 0.22 4.07
CTSD -0.0007054 11662 GTEx DepMap Descartes 2.79 127.76
SLCO2B1 -0.0007165 11697 GTEx DepMap Descartes 0.07 1.26
ITPR2 -0.0007169 11700 GTEx DepMap Descartes 0.07 0.57


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.38e-01
Mean rank of genes in gene set: 6467.27
Median rank of genes in gene set: 7368
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NRXN1 0.0050922 24 GTEx DepMap Descartes 3.83 64.45
SCN7A 0.0026351 108 GTEx DepMap Descartes 0.69 14.39
MARCKS 0.0025211 120 GTEx DepMap Descartes 15.82 546.91
PTN 0.0019916 186 GTEx DepMap Descartes 1.25 124.37
DST 0.0018315 221 GTEx DepMap Descartes 4.03 27.40
SFRP1 0.0015089 301 GTEx DepMap Descartes 1.68 59.50
PPP2R2B 0.0010484 563 GTEx DepMap Descartes 0.96 13.38
EGFLAM 0.0007111 943 GTEx DepMap Descartes 0.22 7.00
SLC35F1 0.0005495 1266 GTEx DepMap Descartes 0.18 5.12
IL1RAPL2 0.0004152 1582 GTEx DepMap Descartes 0.00 0.19
PLCE1 0.0002945 2022 GTEx DepMap Descartes 0.14 1.91
TRPM3 0.0002172 2386 GTEx DepMap Descartes 0.02 0.23
IL1RAPL1 0.0002030 2466 GTEx DepMap Descartes 0.02 0.96
COL25A1 0.0001755 2628 GTEx DepMap Descartes 0.13 2.22
SORCS1 0.0000663 3410 GTEx DepMap Descartes 0.14 2.89
PTPRZ1 0.0000039 4061 GTEx DepMap Descartes 0.01 0.34
HMGA2 -0.0000113 4242 GTEx DepMap Descartes 0.00 0.00
MDGA2 -0.0000179 4330 GTEx DepMap Descartes 0.00 0.06
NRXN3 -0.0000492 4775 GTEx DepMap Descartes 0.03 0.45
STARD13 -0.0000810 5271 GTEx DepMap Descartes 0.05 0.89
LRRTM4 -0.0001714 6714 GTEx DepMap Descartes 0.03 1.42
PLP1 -0.0002051 7194 GTEx DepMap Descartes 0.03 2.30
ERBB3 -0.0002292 7542 GTEx DepMap Descartes 0.01 0.37
XKR4 -0.0002355 7618 GTEx DepMap Descartes 0.02 0.19
COL5A2 -0.0002406 7685 GTEx DepMap Descartes 0.13 2.52
MPZ -0.0002588 7928 GTEx DepMap Descartes 0.03 2.79
SOX5 -0.0003243 8808 GTEx DepMap Descartes 0.36 7.55
ADAMTS5 -0.0003720 9378 GTEx DepMap Descartes 0.01 0.09
ERBB4 -0.0003900 9596 GTEx DepMap Descartes 0.02 0.26
GAS7 -0.0004381 10077 GTEx DepMap Descartes 0.06 1.29


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-01
Mean rank of genes in gene set: 7023.27
Median rank of genes in gene set: 7131
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ANGPT1 0.0018779 205 GTEx DepMap Descartes 0.16 5.42
CD9 0.0016792 253 GTEx DepMap Descartes 2.04 176.59
PDE3A 0.0013906 357 GTEx DepMap Descartes 0.25 4.87
MCTP1 0.0006794 1004 GTEx DepMap Descartes 0.06 1.46
HIPK2 0.0006615 1039 GTEx DepMap Descartes 0.75 6.83
PRKAR2B 0.0005535 1259 GTEx DepMap Descartes 0.88 36.31
LIMS1 0.0000994 3137 GTEx DepMap Descartes 1.01 30.50
DOK6 0.0000803 3298 GTEx DepMap Descartes 0.17 2.57
LTBP1 0.0000280 3785 GTEx DepMap Descartes 0.04 0.70
INPP4B 0.0000233 3827 GTEx DepMap Descartes 0.10 1.63
ITGB3 0.0000221 3839 GTEx DepMap Descartes 0.00 0.02
SLC24A3 -0.0000075 4188 GTEx DepMap Descartes 0.01 0.23
ITGA2B -0.0000309 4509 GTEx DepMap Descartes 0.01 0.46
MED12L -0.0000774 5216 GTEx DepMap Descartes 0.04 0.56
P2RX1 -0.0001067 5675 GTEx DepMap Descartes 0.00 0.02
ACTB -0.0001230 5963 GTEx DepMap Descartes 32.24 2011.59
TRPC6 -0.0001281 6040 GTEx DepMap Descartes 0.01 0.22
TUBB1 -0.0001352 6156 GTEx DepMap Descartes 0.00 0.09
ARHGAP6 -0.0001412 6252 GTEx DepMap Descartes 0.01 0.12
GP1BA -0.0001448 6323 GTEx DepMap Descartes 0.00 0.02
STON2 -0.0001789 6817 GTEx DepMap Descartes 0.08 2.68
UBASH3B -0.0001908 6984 GTEx DepMap Descartes 0.04 0.84
ACTN1 -0.0002005 7131 GTEx DepMap Descartes 0.74 23.02
VCL -0.0002118 7291 GTEx DepMap Descartes 0.20 3.33
RAP1B -0.0002201 7412 GTEx DepMap Descartes 1.05 11.12
PSTPIP2 -0.0002514 7827 GTEx DepMap Descartes 0.03 0.86
TLN1 -0.0002928 8378 GTEx DepMap Descartes 0.45 6.62
MMRN1 -0.0002988 8466 GTEx DepMap Descartes 0.01 0.31
RAB27B -0.0003253 8826 GTEx DepMap Descartes 0.02 0.31
SPN -0.0003277 8855 GTEx DepMap Descartes 0.01 0.20


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 7350.71
Median rank of genes in gene set: 9172
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMSB10 0.0030627 79 GTEx DepMap Descartes 102.83 32472.88
STK39 0.0013825 361 GTEx DepMap Descartes 0.79 36.81
ARID5B 0.0009763 639 GTEx DepMap Descartes 0.67 13.98
BCL2 0.0009714 645 GTEx DepMap Descartes 0.80 16.62
BACH2 0.0004853 1419 GTEx DepMap Descartes 0.32 5.63
PITPNC1 0.0004667 1464 GTEx DepMap Descartes 0.38 8.74
SP100 0.0003587 1761 GTEx DepMap Descartes 0.26 6.73
ABLIM1 0.0003061 1979 GTEx DepMap Descartes 0.43 7.69
GNG2 0.0001587 2732 GTEx DepMap Descartes 0.88 35.94
SORL1 0.0001284 2932 GTEx DepMap Descartes 0.36 4.99
FYN 0.0000660 3414 GTEx DepMap Descartes 1.58 66.91
MCTP2 0.0000517 3548 GTEx DepMap Descartes 0.07 1.23
B2M 0.0000365 3691 GTEx DepMap Descartes 33.79 1879.39
CCND3 0.0000058 4036 GTEx DepMap Descartes 0.31 18.73
EVL -0.0000338 4554 GTEx DepMap Descartes 2.54 98.60
NCALD -0.0000389 4632 GTEx DepMap Descartes 0.12 4.59
ITPKB -0.0002456 7753 GTEx DepMap Descartes 0.01 0.13
SAMD3 -0.0002465 7765 GTEx DepMap Descartes 0.01 0.35
ANKRD44 -0.0002634 8004 GTEx DepMap Descartes 0.16 3.36
WIPF1 -0.0003321 8915 GTEx DepMap Descartes 0.19 5.62
PLEKHA2 -0.0003475 9099 GTEx DepMap Descartes 0.04 0.88
SKAP1 -0.0003604 9245 GTEx DepMap Descartes 0.01 0.75
PRKCH -0.0003718 9373 GTEx DepMap Descartes 0.01 0.44
CCL5 -0.0003734 9395 GTEx DepMap Descartes 0.12 15.32
SCML4 -0.0003803 9481 GTEx DepMap Descartes 0.07 2.33
LEF1 -0.0003881 9573 GTEx DepMap Descartes 0.02 1.07
RCSD1 -0.0004325 10033 GTEx DepMap Descartes 0.02 0.41
IKZF1 -0.0004489 10181 GTEx DepMap Descartes 0.03 0.47
ETS1 -0.0004532 10221 GTEx DepMap Descartes 0.06 1.46
ARHGAP15 -0.0005213 10768 GTEx DepMap Descartes 0.04 1.30


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Epithelial cells: Epithelial cells (model markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.74e-02
Mean rank of genes in gene set: 2235
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
WFDC2 0.0006825 998 GTEx DepMap Descartes 0.27 52.20
CDH3 0.0000599 3472 GTEx DepMap Descartes 0.01 0.61


Megakaryocyte precursor: Megakaryocyte precursor (model markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.27e-02
Mean rank of genes in gene set: 2349.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ADRA2A 0.0026996 101 GTEx DepMap Descartes 0.07 2.53
SLC10A5 -0.0000365 4598 GTEx DepMap Descartes 0.01 0.35


Mast cells: Mast cells (model markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.46e-02
Mean rank of genes in gene set: 777
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CPA3 0.0008332 777 GTEx DepMap Descartes 0 0.05