Program: 5. M2 Macrophages.

Program: 5. M2 Macrophages.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 GPR34 0.0056666 G protein-coupled receptor 34 GTEx DepMap Descartes 1.04 139.12
2 CD74 0.0054301 CD74 molecule GTEx DepMap Descartes 65.93 4913.08
3 LY96 0.0048981 lymphocyte antigen 96 GTEx DepMap Descartes 2.78 1167.38
4 APOE 0.0048557 apolipoprotein E GTEx DepMap Descartes 111.84 19982.59
5 CSF1R 0.0046462 colony stimulating factor 1 receptor GTEx DepMap Descartes 1.62 101.09
6 RGS1 0.0046097 regulator of G protein signaling 1 GTEx DepMap Descartes 11.69 1092.35
7 TYROBP 0.0045763 transmembrane immune signaling adaptor TYROBP GTEx DepMap Descartes 24.57 9093.27
8 CTSC 0.0045505 cathepsin C GTEx DepMap Descartes 6.69 215.02
9 MS4A4A 0.0045325 membrane spanning 4-domains A4A GTEx DepMap Descartes 2.87 390.85
10 GRN 0.0044949 granulin precursor GTEx DepMap Descartes 9.02 866.07
11 GPR183 0.0044557 G protein-coupled receptor 183 GTEx DepMap Descartes 8.17 1138.42
12 LY86 0.0044419 lymphocyte antigen 86 GTEx DepMap Descartes 1.61 304.76
13 SLC40A1 0.0043502 solute carrier family 40 member 1 GTEx DepMap Descartes 3.43 229.09
14 CD14 0.0043031 CD14 molecule GTEx DepMap Descartes 9.04 1277.56
15 AIF1 0.0042618 allograft inflammatory factor 1 GTEx DepMap Descartes 10.76 2007.16
16 LPAR6 0.0042585 lysophosphatidic acid receptor 6 GTEx DepMap Descartes 1.05 91.36
17 ITM2B 0.0041823 integral membrane protein 2B GTEx DepMap Descartes 13.56 309.41
18 C3AR1 0.0041516 complement C3a receptor 1 GTEx DepMap Descartes 0.96 66.56
19 AXL 0.0038739 AXL receptor tyrosine kinase GTEx DepMap Descartes 0.97 48.90
20 NPC2 0.0038508 NPC intracellular cholesterol transporter 2 GTEx DepMap Descartes 10.69 1683.04
21 FCGRT 0.0038318 Fc gamma receptor and transporter GTEx DepMap Descartes 8.62 775.87
22 SLCO2B1 0.0038006 solute carrier organic anion transporter family member 2B1 GTEx DepMap Descartes 0.93 37.17
23 MSR1 0.0037970 macrophage scavenger receptor 1 GTEx DepMap Descartes 1.07 67.98
24 SAT1 0.0037539 spermidine/spermine N1-acetyltransferase 1 GTEx DepMap Descartes 35.19 7055.67
25 CREG1 0.0037000 cellular repressor of E1A stimulated genes 1 GTEx DepMap Descartes 3.29 354.41
26 CYBB 0.0036684 cytochrome b-245 beta chain GTEx DepMap Descartes 1.57 80.84
27 CXCL16 0.0036238 C-X-C motif chemokine ligand 16 GTEx DepMap Descartes 2.07 209.99
28 PILRA 0.0036220 paired immunoglobin like type 2 receptor alpha GTEx DepMap Descartes 1.20 214.30
29 LGMN 0.0035878 legumain GTEx DepMap Descartes 5.39 553.58
30 ADAP2 0.0035641 ArfGAP with dual PH domains 2 GTEx DepMap Descartes 1.12 100.05
31 CTSS 0.0035584 cathepsin S GTEx DepMap Descartes 6.40 319.89
32 TNF 0.0035490 tumor necrosis factor GTEx DepMap Descartes 1.49 195.94
33 ZFP36 0.0034986 ZFP36 ring finger protein GTEx DepMap Descartes 11.38 1561.60
34 TBXAS1 0.0034728 thromboxane A synthase 1 GTEx DepMap Descartes 0.75 70.75
35 GADD45B 0.0034341 growth arrest and DNA damage inducible beta GTEx DepMap Descartes 8.62 995.44
36 PSAP 0.0034142 prosaposin GTEx DepMap Descartes 13.76 1005.97
37 CD163 0.0033668 CD163 molecule GTEx DepMap Descartes 1.52 69.97
38 IGSF6 0.0033665 immunoglobulin superfamily member 6 GTEx DepMap Descartes 2.39 177.37
39 B2M 0.0033605 beta-2-microglobulin GTEx DepMap Descartes 118.31 10721.59
40 PLD4 0.0032722 phospholipase D family member 4 GTEx DepMap Descartes 0.87 98.23
41 HNMT 0.0032551 histamine N-methyltransferase GTEx DepMap Descartes 1.20 85.77
42 SGK1 0.0032475 serum/glucocorticoid regulated kinase 1 GTEx DepMap Descartes 4.09 168.95
43 RB1 0.0032193 RB transcriptional corepressor 1 GTEx DepMap Descartes 1.23 60.99
44 TMEM176B 0.0032119 transmembrane protein 176B GTEx DepMap Descartes 4.49 673.71
45 DAB2 0.0032004 DAB adaptor protein 2 GTEx DepMap Descartes 1.83 95.63
46 PRDM1 0.0031574 PR/SET domain 1 GTEx DepMap Descartes 0.94 42.41
47 TNFSF13B 0.0031291 TNF superfamily member 13b GTEx DepMap Descartes 2.07 168.09
48 TLR7 0.0031060 toll like receptor 7 GTEx DepMap Descartes 0.25 11.63
49 CPVL 0.0030611 carboxypeptidase vitellogenic like GTEx DepMap Descartes 2.19 212.30
50 FGL2 0.0030344 fibrinogen like 2 GTEx DepMap Descartes 2.54 131.78


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UMAP plots showing activity of gene expression program identified in GEP 5. M2 Macrophages:

Interactive UMAP Plot
Interactive UMAP Plot
Interactive Boxplot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MACROPHAGES 3.10e-34 149.65 76.79 2.60e-32 2.08e-31
21GPR34, CD74, APOE, CSF1R, RGS1, TYROBP, GRN, GPR183, LY86, SLC40A1, CD14, AIF1, C3AR1, NPC2, MSR1, CXCL16, CTSS, IGSF6, PLD4, SGK1, FGL2
 81
CUI_DEVELOPING_HEART_C8_MACROPHAGE 4.23e-52 149.37 76.38 2.84e-49 2.84e-49
37GPR34, CD74, LY96, CSF1R, RGS1, TYROBP, CTSC, MS4A4A, GRN, GPR183, LY86, CD14, AIF1, LPAR6, C3AR1, NPC2, FCGRT, SLCO2B1, MSR1, CREG1, CYBB, CXCL16, PILRA, LGMN, ADAP2, CTSS, ZFP36, TBXAS1, GADD45B, PSAP, CD163, IGSF6, PLD4, SGK1, RB1, CPVL, FGL2
 275
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 1.39e-46 124.03 65.97 2.33e-44 9.33e-44
33GPR34, CSF1R, RGS1, TYROBP, CTSC, MS4A4A, GRN, SLC40A1, CD14, AIF1, C3AR1, AXL, NPC2, FCGRT, SLCO2B1, MSR1, SAT1, CREG1, CYBB, CXCL16, PILRA, LGMN, ADAP2, CTSS, TBXAS1, PSAP, CD163, IGSF6, SGK1, DAB2, TNFSF13B, CPVL, FGL2
 228
ZHONG_PFC_MAJOR_TYPES_MICROGLIA 1.93e-48 111.07 55.33 6.46e-46 1.29e-45
39GPR34, CD74, LY96, APOE, CSF1R, RGS1, TYROBP, CTSC, GRN, GPR183, LY86, CD14, AIF1, LPAR6, ITM2B, C3AR1, AXL, NPC2, FCGRT, SLCO2B1, SAT1, CREG1, CYBB, CXCL16, LGMN, ADAP2, CTSS, ZFP36, TBXAS1, GADD45B, PSAP, IGSF6, B2M, PLD4, SGK1, RB1, DAB2, TLR7, CPVL
 438
FAN_EMBRYONIC_CTX_BIG_GROUPS_MICROGLIA 3.73e-47 106.58 54.74 8.34e-45 2.50e-44
37GPR34, CD74, LY96, APOE, CSF1R, RGS1, TYROBP, CTSC, GRN, GPR183, LY86, CD14, AIF1, LPAR6, ITM2B, C3AR1, NPC2, FCGRT, SLCO2B1, SAT1, CREG1, CYBB, CXCL16, LGMN, ADAP2, CTSS, ZFP36, TBXAS1, GADD45B, PSAP, IGSF6, B2M, PLD4, RB1, DAB2, TLR7, CPVL
 371
HU_FETAL_RETINA_MICROGLIA 1.07e-44 92.92 48.41 1.43e-42 7.16e-42
36GPR34, CD74, LY96, CSF1R, RGS1, TYROBP, CTSC, GRN, GPR183, LY86, CD14, AIF1, LPAR6, ITM2B, C3AR1, NPC2, FCGRT, SLCO2B1, SAT1, CREG1, CYBB, CXCL16, LGMN, ADAP2, CTSS, ZFP36, TBXAS1, GADD45B, PSAP, IGSF6, B2M, PLD4, SGK1, RB1, CPVL, FGL2
 382
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 2.48e-36 84.74 45.75 2.38e-34 1.67e-33
27GPR34, CSF1R, RGS1, TYROBP, MS4A4A, GRN, GPR183, LY86, AIF1, C3AR1, AXL, NPC2, SLCO2B1, MSR1, SAT1, CYBB, CXCL16, CTSS, TBXAS1, PSAP, CD163, IGSF6, PLD4, SGK1, TNFSF13B, CPVL, FGL2
 200
MANNO_MIDBRAIN_NEUROTYPES_HMGL 6.15e-42 73.48 37.39 6.87e-40 4.12e-39
38GPR34, CD74, LY96, APOE, CSF1R, RGS1, TYROBP, CTSC, MS4A4A, GRN, GPR183, LY86, CD14, LPAR6, ITM2B, C3AR1, AXL, NPC2, FCGRT, SLCO2B1, SAT1, CREG1, CYBB, LGMN, ADAP2, CTSS, ZFP36, GADD45B, CD163, IGSF6, B2M, PLD4, SGK1, DAB2, PRDM1, TLR7, CPVL, FGL2
 577
FAN_EMBRYONIC_CTX_MICROGLIA_3 1.08e-10 121.28 36.43 1.81e-09 7.24e-08
6GPR34, CTSC, SLCO2B1, CREG1, LGMN, TBXAS1
 20
TRAVAGLINI_LUNG_IGSF21_DENDRITIC_CELL 1.13e-13 73.77 29.45 2.23e-12 7.58e-11
9CSF1R, MS4A4A, SLCO2B1, MSR1, CXCL16, LGMN, HNMT, TMEM176B, DAB2
 46
AIZARANI_LIVER_C18_NK_NKT_CELLS_5 6.46e-21 55.87 27.93 2.55e-19 4.34e-18
16CSF1R, TYROBP, GPR183, AIF1, C3AR1, NPC2, SAT1, CYBB, CTSS, GADD45B, PSAP, CD163, IGSF6, SGK1, CPVL, FGL2
 121
AIZARANI_LIVER_C25_KUPFFER_CELLS_4 2.97e-23 49.37 25.76 1.33e-21 1.99e-20
19CSF1R, RGS1, TYROBP, GRN, GPR183, AIF1, NPC2, SAT1, CYBB, CXCL16, CTSS, PSAP, CD163, IGSF6, PLD4, SGK1, TNFSF13B, CPVL, FGL2
 174
TRAVAGLINI_LUNG_MACROPHAGE_CELL 1.07e-23 46.02 24.28 5.15e-22 7.21e-21
20CD74, APOE, TYROBP, CTSC, MS4A4A, GRN, C3AR1, NPC2, FCGRT, SLCO2B1, MSR1, CYBB, CXCL16, PILRA, CTSS, PSAP, CD163, IGSF6, HNMT, DAB2
 201
TRAVAGLINI_LUNG_TREM2_DENDRITIC_CELL 2.52e-33 45.08 24.22 1.88e-31 1.69e-30
33CD74, LY96, APOE, CSF1R, TYROBP, CTSC, MS4A4A, GRN, LY86, SLC40A1, CD14, AIF1, ITM2B, C3AR1, AXL, NPC2, FCGRT, SLCO2B1, MSR1, CREG1, CYBB, CXCL16, PILRA, LGMN, CTSS, PSAP, IGSF6, HNMT, SGK1, TMEM176B, DAB2, TNFSF13B, CPVL
 572
DESCARTES_FETAL_INTESTINE_MYELOID_CELLS 2.93e-24 43.93 23.39 1.51e-22 1.97e-21
21GPR34, CD74, CSF1R, TYROBP, MS4A4A, GPR183, LY86, CD14, AIF1, C3AR1, CYBB, LGMN, ADAP2, CTSS, TBXAS1, CD163, IGSF6, PLD4, TLR7, CPVL, FGL2
 227
GAO_LARGE_INTESTINE_24W_C11_PANETH_LIKE_CELL 3.22e-27 41.72 22.68 2.16e-25 2.16e-24
25GPR34, CD74, CSF1R, TYROBP, CTSC, MS4A4A, LY86, CD14, AIF1, LPAR6, SLCO2B1, CREG1, CYBB, CXCL16, LGMN, ADAP2, TNF, TBXAS1, CD163, IGSF6, SGK1, DAB2, TNFSF13B, CPVL, FGL2
 325
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MONOCYTES 1.41e-10 63.40 22.38 2.30e-09 9.44e-08
7CD74, RGS1, TYROBP, GPR183, AIF1, SGK1, FGL2
 39
DESCARTES_FETAL_HEART_MYELOID_CELLS 1.68e-18 44.97 22.20 5.65e-17 1.13e-15
15GPR34, CD74, CSF1R, TYROBP, MS4A4A, CD14, C3AR1, SLCO2B1, CYBB, PILRA, LGMN, CD163, IGSF6, PLD4, TLR7
 134
DESCARTES_FETAL_STOMACH_MYELOID_CELLS 2.87e-13 47.27 20.21 5.50e-12 1.92e-10
10CD74, TYROBP, LY86, CD14, CYBB, ADAP2, TBXAS1, IGSF6, PLD4, CPVL
 76
MENON_FETAL_KIDNEY_10_IMMUNE_CELLS 7.12e-13 42.73 18.35 1.30e-11 4.78e-10
10CD74, TYROBP, AIF1, SAT1, CYBB, PSAP, IGSF6, B2M, DAB2, FGL2
 83

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_INFLAMMATORY_RESPONSE 1.19e-05 10.54 3.95 5.94e-04 5.94e-04
7RGS1, GPR183, CD14, C3AR1, AXL, MSR1, CYBB
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.24e-04 8.78 3.02 2.06e-03 6.18e-03
6GPR183, SAT1, TNF, ZFP36, GADD45B, SGK1
 200
HALLMARK_ALLOGRAFT_REJECTION 1.24e-04 8.78 3.02 2.06e-03 6.18e-03
6CD74, LY86, CTSS, TNF, IGSF6, B2M
 200
HALLMARK_KRAS_SIGNALING_UP 1.08e-03 7.12 2.18 1.35e-02 5.40e-02
5LY96, C3AR1, CTSS, TMEM176B, PRDM1
 200
HALLMARK_APOPTOSIS 3.63e-03 6.92 1.79 3.63e-02 1.82e-01
4CD14, SAT1, TNF, GADD45B
 161
HALLMARK_INTERFERON_ALPHA_RESPONSE 6.61e-03 8.48 1.66 5.13e-02 3.30e-01
3CD74, LPAR6, B2M
 97
HALLMARK_ANDROGEN_RESPONSE 7.18e-03 8.22 1.61 5.13e-02 3.59e-01
3SAT1, B2M, SGK1
 100
HALLMARK_CHOLESTEROL_HOMEOSTASIS 3.47e-02 7.23 0.84 1.66e-01 1.00e+00
2CXCL16, LGMN
 74
HALLMARK_IL2_STAT5_SIGNALING 4.30e-02 4.07 0.80 1.66e-01 1.00e+00
3GADD45B, TLR7, FGL2
 199
HALLMARK_INTERFERON_GAMMA_RESPONSE 4.35e-02 4.05 0.80 1.66e-01 1.00e+00
3CD74, B2M, FGL2
 200
HALLMARK_COMPLEMENT 4.35e-02 4.05 0.80 1.66e-01 1.00e+00
3CTSC, LGMN, CTSS
 200
HALLMARK_MTORC1_SIGNALING 4.35e-02 4.05 0.80 1.66e-01 1.00e+00
3CTSC, LGMN, FGL2
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 4.35e-02 4.05 0.80 1.66e-01 1.00e+00
3SAT1, GADD45B, DAB2
 200
HALLMARK_IL6_JAK_STAT3_SIGNALING 4.64e-02 6.13 0.71 1.66e-01 1.00e+00
2CD14, TNF
 87
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 5.13e-01 1.00e+00
2ZFP36, SGK1
 200
HALLMARK_MYOGENESIS 1.85e-01 2.63 0.31 5.13e-01 1.00e+00
2GADD45B, RB1
 200
HALLMARK_XENOBIOTIC_METABOLISM 1.85e-01 2.63 0.31 5.13e-01 1.00e+00
2APOE, TMEM176B
 200
HALLMARK_P53_PATHWAY 1.85e-01 2.63 0.31 5.13e-01 1.00e+00
2SAT1, RB1
 200
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 8.35e-01 1.00e+00
1CTSC
 96
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 1.00e+00 1.00e+00
1LGMN
 138

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_LYSOSOME 1.10e-04 11.97 3.64 2.04e-02 2.04e-02
5CTSC, NPC2, LGMN, CTSS, PSAP
 121
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 3.96e-04 12.93 3.31 3.68e-02 7.37e-02
4CD74, LGMN, CTSS, B2M
 88
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 6.90e-04 11.09 2.84 4.28e-02 1.28e-01
4LY96, CD14, TNF, TLR7
 102
KEGG_HEMATOPOIETIC_CELL_LINEAGE 4.89e-03 9.50 1.85 2.28e-01 9.10e-01
3CSF1R, CD14, TNF
 87
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.07e-02 9.64 1.11 6.42e-01 1.00e+00
2LY96, CD14
 56
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 1.96e-02 4.16 1.08 6.42e-01 1.00e+00
4CSF1R, CXCL16, TNF, TNFSF13B
 265
KEGG_MAPK_SIGNALING_PATHWAY 8.58e-02 3.02 0.60 1.00e+00 1.00e+00
3CD14, TNF, GADD45B
 267
KEGG_CELL_CYCLE 8.71e-02 4.23 0.49 1.00e+00 1.00e+00
2GADD45B, RB1
 125
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.01e-01 3.86 0.45 1.00e+00 1.00e+00
2TYROBP, TNF
 137
KEGG_ALZHEIMERS_DISEASE 1.39e-01 3.18 0.37 1.00e+00 1.00e+00
2APOE, TNF
 166
KEGG_ENDOCYTOSIS 1.59e-01 2.91 0.34 1.00e+00 1.00e+00
2CSF1R, DAB2
 181
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.87e-01 1.93 0.23 1.00e+00 1.00e+00
2LPAR6, C3AR1
 272
KEGG_HISTIDINE_METABOLISM 1.09e-01 9.11 0.22 1.00e+00 1.00e+00
1HNMT
 29
KEGG_ASTHMA 1.13e-01 8.79 0.21 1.00e+00 1.00e+00
1TNF
 30
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2CSF1R, RB1
 325
KEGG_ALLOGRAFT_REJECTION 1.37e-01 7.08 0.17 1.00e+00 1.00e+00
1TNF
 37
KEGG_GRAFT_VERSUS_HOST_DISEASE 1.51e-01 6.37 0.15 1.00e+00 1.00e+00
1TNF
 41
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1SGK1
 42
KEGG_BLADDER_CANCER 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1RB1
 42
KEGG_TYPE_I_DIABETES_MELLITUS 1.57e-01 6.07 0.15 1.00e+00 1.00e+00
1TNF
 43

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr13q14 6.72e-02 3.37 0.67 1.00e+00 1.00e+00
3LPAR6, ITM2B, RB1
 240
chr19q13 6.12e-01 1.20 0.37 1.00e+00 1.00e+00
5APOE, TYROBP, AXL, FCGRT, ZFP36
 1165
chrXp22 2.31e-01 2.25 0.26 1.00e+00 1.00e+00
2SAT1, TLR7
 233
chr12p13 3.72e-01 1.57 0.18 1.00e+00 1.00e+00
2C3AR1, CD163
 333
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1MSR1
 45
chr6p21 7.00e-01 1.12 0.13 1.00e+00 1.00e+00
2AIF1, TNF
 467
chr13q33 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1TNFSF13B
 55
chr14q32 1.00e+00 0.96 0.11 1.00e+00 1.00e+00
2LGMN, PLD4
 546
chr2q22 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1HNMT
 68
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1RGS1
 71
chr6p25 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1LY86
 82
chrXp21 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1CYBB
 82
chr13q32 3.15e-01 2.71 0.07 1.00e+00 1.00e+00
1GPR183
 95
chr6q23 3.44e-01 2.43 0.06 1.00e+00 1.00e+00
1SGK1
 106
chr2q32 3.49e-01 2.38 0.06 1.00e+00 1.00e+00
1SLC40A1
 108
chr5q33 3.52e-01 2.36 0.06 1.00e+00 1.00e+00
1CD74
 109
chr6q21 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1PRDM1
 117
chr1q24 3.87e-01 2.09 0.05 1.00e+00 1.00e+00
1CREG1
 123
chr5p13 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1DAB2
 128
chr11q14 4.29e-01 1.82 0.04 1.00e+00 1.00e+00
1CTSC
 141

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
IRF_Q6 4.18e-05 8.59 3.23 2.97e-02 4.74e-02
7LY86, SLC40A1, SAT1, CYBB, B2M, TNFSF13B, TLR7
 244
ICSBP_Q6 5.24e-05 8.27 3.11 2.97e-02 5.94e-02
7LY86, AIF1, CXCL16, CTSS, B2M, TNFSF13B, TLR7
 253
ISRE_01 2.97e-03 5.60 1.72 5.66e-01 1.00e+00
5LY86, AIF1, B2M, TNFSF13B, TLR7
 253
IRF1_Q6 3.50e-03 5.38 1.65 5.66e-01 1.00e+00
5TYROBP, LY86, CTSS, SGK1, TNFSF13B
 263
TGANTCA_AP1_C 7.29e-03 2.77 1.23 8.56e-01 1.00e+00
10CSF1R, GPR183, ITM2B, C3AR1, SAT1, ADAP2, TBXAS1, GADD45B, SGK1, PRDM1
 1139
ZNF768_TARGET_GENES 7.32e-03 2.64 1.22 8.56e-01 1.00e+00
11APOE, TYROBP, CTSC, GRN, GPR183, LY86, SLCO2B1, CTSS, B2M, SGK1, CPVL
 1346
TERF1_TARGET_GENES 2.75e-02 3.74 0.97 1.00e+00 1.00e+00
4CD74, RGS1, CTSS, PRDM1
 295
MAPK3_TARGET_GENES 2.73e-02 8.26 0.95 1.00e+00 1.00e+00
2SAT1, B2M
 65
HTF_01 3.21e-02 7.55 0.87 1.00e+00 1.00e+00
2RGS1, SGK1
 71
FOXJ2_01 3.69e-02 4.34 0.86 1.00e+00 1.00e+00
3TNF, TBXAS1, PRDM1
 187
HNF3_Q6 3.94e-02 4.22 0.83 1.00e+00 1.00e+00
3TBXAS1, SGK1, PRDM1
 192
BACH2_TARGET_GENES 9.82e-02 1.78 0.82 1.00e+00 1.00e+00
11LY96, CSF1R, RGS1, GPR183, SLCO2B1, MSR1, TBXAS1, PSAP, DAB2, PRDM1, FGL2
 1998
HFH3_01 4.14e-02 4.13 0.82 1.00e+00 1.00e+00
3TNF, SGK1, PRDM1
 196
HNF3ALPHA_Q6 4.95e-02 3.84 0.76 1.00e+00 1.00e+00
3TBXAS1, SGK1, PRDM1
 211
ZNF213_TARGET_GENES 7.45e-02 2.35 0.73 1.00e+00 1.00e+00
5GRN, FCGRT, CXCL16, ADAP2, GADD45B
 595
FAC1_01 5.71e-02 3.61 0.71 1.00e+00 1.00e+00
3SAT1, TBXAS1, SGK1
 224
MAP2K1_TARGET_GENES 3.53e-02 31.82 0.70 1.00e+00 1.00e+00
1SGK1
 9
RYTTCCTG_ETS2_B 1.23e-01 1.84 0.70 1.00e+00 1.00e+00
7TYROBP, GPR183, CTSS, PSAP, SGK1, PRDM1, TNFSF13B
 1112
NOTCH3_TARGET_GENES 1.89e-01 1.80 0.68 1.00e+00 1.00e+00
7GRN, SLC40A1, SAT1, CXCL16, LGMN, CD163, RB1
 1135
NFKAPPAB65_01 6.79e-02 3.35 0.66 1.00e+00 1.00e+00
3CSF1R, CXCL16, GADD45B
 241

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_RESPONSE_TO_ALDOSTERONE 1.54e-04 172.68 14.09 2.34e-02 1.00e+00
2CYBB, SGK1
 5
GOBP_MICROGLIAL_CELL_ACTIVATION 2.72e-08 41.49 13.69 3.89e-05 2.04e-04
6TYROBP, CTSC, GRN, AIF1, TNF, TLR7
 47
GOBP_GLYCOLIPID_TRANSPORT 3.22e-04 103.49 9.64 3.60e-02 1.00e+00
2NPC2, PSAP
 7
GOBP_POSITIVE_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY 4.28e-04 86.37 8.33 4.33e-02 1.00e+00
2LY96, LY86
 8
GOBP_REGULATION_OF_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 4.28e-04 86.37 8.33 4.33e-02 1.00e+00
2LY96, CD14
 8
GOBP_MACROPHAGE_ACTIVATION 1.35e-07 21.41 7.92 1.26e-04 1.01e-03
7CD74, TYROBP, CTSC, GRN, AIF1, TNF, TLR7
 102
GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION 3.70e-06 25.20 7.53 1.54e-03 2.77e-02
5CD74, CSF1R, AIF1, TNF, TLR7
 60
GOBP_CELLULAR_RESPONSE_TO_NICOTINE 5.49e-04 74.10 7.33 4.84e-02 1.00e+00
2TNF, B2M
 9
GOBP_REGULATION_OF_NATURAL_KILLER_CELL_DIFFERENTIATION 6.85e-04 64.86 6.55 5.66e-02 1.00e+00
2AXL, PRDM1
 10
GOBP_POSITIVE_REGULATION_OF_CHEMOKINE_C_X_C_MOTIF_LIGAND_2_PRODUCTION 6.85e-04 64.86 6.55 5.66e-02 1.00e+00
2CD74, TNF
 10
GOBP_REGULATION_OF_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION 8.35e-04 57.69 5.91 6.50e-02 1.00e+00
2CD74, FGL2
 11
GOBP_ACTIVATION_OF_MAPKKK_ACTIVITY 9.99e-04 51.89 5.39 7.26e-02 1.00e+00
2TNF, GADD45B
 12
GOBP_NEGATIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION 9.99e-04 51.89 5.39 7.26e-02 1.00e+00
2APOE, TYROBP
 12
GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION 2.16e-05 17.14 5.17 5.78e-03 1.62e-01
5CD74, TYROBP, AIF1, TNF, TLR7
 86
GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION 7.41e-05 20.48 5.17 1.45e-02 5.54e-01
4CD74, CD14, TNF, TLR7
 57
GOBP_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION 7.93e-05 20.12 5.08 1.45e-02 5.93e-01
4CD74, TYROBP, TNF, RB1
 58
GOBP_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY 7.93e-05 20.12 5.08 1.45e-02 5.93e-01
4LY96, LY86, CD14, TNF
 58
GOBP_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION 2.96e-04 26.56 5.01 3.52e-02 1.00e+00
3TYROBP, AXL, PRDM1
 33
GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS 2.84e-05 16.14 4.88 6.86e-03 2.13e-01
5CD74, CSF1R, AIF1, C3AR1, LGMN
 91
GOBP_REGULATION_OF_B_CELL_PROLIFERATION 9.66e-05 19.05 4.82 1.72e-02 7.23e-01
4CD74, TYROBP, GPR183, TNFSF13B
 61

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_DN 6.65e-19 35.18 18.04 3.24e-15 3.24e-15
17LY96, CSF1R, TYROBP, CTSC, MS4A4A, GRN, CD14, LPAR6, NPC2, FCGRT, CREG1, PILRA, PSAP, CD163, IGSF6, TMEM176B, FGL2
 200
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 2.27e-17 31.95 16.17 2.76e-14 1.10e-13
16CD74, CSF1R, TYROBP, GRN, CD14, AIF1, FCGRT, CREG1, CYBB, PILRA, ADAP2, TBXAS1, PSAP, IGSF6, HNMT, FGL2
 200
GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_DN 2.27e-17 31.95 16.17 2.76e-14 1.10e-13
16CSF1R, TYROBP, AIF1, LPAR6, C3AR1, FCGRT, SAT1, CREG1, PILRA, ADAP2, TBXAS1, PSAP, CD163, IGSF6, HNMT, FGL2
 200
GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN 2.27e-17 31.95 16.17 2.76e-14 1.10e-13
16LY96, CSF1R, TYROBP, GRN, CD14, NPC2, SAT1, CREG1, CYBB, PILRA, ADAP2, CTSS, PSAP, IGSF6, CPVL, FGL2
 200
GSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_UP 5.62e-16 29.42 14.66 4.92e-13 2.74e-12
15CSF1R, TYROBP, GRN, CD14, C3AR1, FCGRT, MSR1, SAT1, CREG1, CYBB, CXCL16, PILRA, PSAP, CD163, IGSF6
 197
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_DN 6.06e-16 29.25 14.58 4.92e-13 2.95e-12
15LY96, TYROBP, CTSC, CD14, LPAR6, FCGRT, SAT1, CREG1, CYBB, CTSS, PSAP, CD163, HNMT, TMEM176B, FGL2
 198
GSE34156_UNTREATED_VS_6H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_UP 1.61e-14 26.55 13.00 9.64e-12 7.83e-11
14LY96, CSF1R, GRN, CD14, NPC2, FCGRT, MSR1, CREG1, CYBB, CXCL16, PILRA, PSAP, CD163, IGSF6
 197
GSE24634_TEFF_VS_TCONV_DAY3_IN_CULTURE_DN 1.98e-14 26.13 12.79 9.64e-12 9.64e-11
14LY96, MS4A4A, CD14, LPAR6, FCGRT, CYBB, PILRA, ADAP2, CD163, HNMT, RB1, DAB2, CPVL, FGL2
 200
GSE29618_MONOCYTE_VS_PDC_DAY7_FLU_VACCINE_UP 1.98e-14 26.13 12.79 9.64e-12 9.64e-11
14CSF1R, CD14, AIF1, ITM2B, SAT1, CREG1, PILRA, ADAP2, CTSS, TBXAS1, CD163, IGSF6, SGK1, FGL2
 200
GSE29618_MONOCYTE_VS_MDC_DAY7_FLU_VACCINE_UP 1.98e-14 26.13 12.79 9.64e-12 9.64e-11
14CD14, AIF1, ITM2B, C3AR1, NPC2, SAT1, CREG1, CYBB, PILRA, CTSS, TBXAS1, PSAP, CD163, HNMT
 200
GSE34156_NOD2_LIGAND_VS_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_DN 9.65e-12 21.32 9.98 2.80e-09 4.70e-08
12TYROBP, GRN, CD14, C3AR1, MSR1, SAT1, CREG1, CYBB, CXCL16, PILRA, CD163, IGSF6
 197
GSE29618_MONOCYTE_VS_PDC_UP 1.08e-11 21.10 9.88 2.80e-09 5.29e-08
12CSF1R, TYROBP, LY86, CD14, AIF1, ITM2B, CREG1, PILRA, CTSS, TBXAS1, CD163, FGL2
 199
GSE10325_BCELL_VS_MYELOID_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12CSF1R, AIF1, C3AR1, FCGRT, SAT1, PILRA, TBXAS1, PSAP, CD163, IGSF6, CPVL, FGL2
 200
GSE22886_NAIVE_TCELL_VS_MONOCYTE_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12LY96, GRN, CD14, NPC2, CREG1, CYBB, PILRA, ADAP2, PSAP, IGSF6, CPVL, FGL2
 200
GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12LY96, GRN, CD14, NPC2, CREG1, CYBB, PILRA, ADAP2, CTSS, PSAP, IGSF6, FGL2
 200
GSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY5_UP 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12CSF1R, MS4A4A, NPC2, SLCO2B1, CREG1, PILRA, LGMN, TBXAS1, IGSF6, HNMT, TMEM176B, CPVL
 200
GSE29618_MONOCYTE_VS_MDC_UP 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12TYROBP, CD14, AIF1, ITM2B, NPC2, CREG1, CYBB, PILRA, CTSS, PSAP, CD163, HNMT
 200
GSE29618_BCELL_VS_MONOCYTE_DAY7_FLU_VACCINE_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12CSF1R, TYROBP, GRN, CD14, ITM2B, FCGRT, CREG1, PILRA, TBXAS1, PSAP, CD163, SGK1
 200
GSE21774_CD62L_POS_CD56_BRIGHT_VS_CD62L_NEG_CD56_DIM_NK_CELL_UP 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12CSF1R, TYROBP, LY86, CD14, CYBB, TNF, CD163, IGSF6, PLD4, DAB2, TNFSF13B, TLR7
 200
GSE34156_UNTREATED_VS_24H_NOD2_LIGAND_TREATED_MONOCYTE_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12LY96, CSF1R, GRN, CD14, NPC2, SAT1, CREG1, CYBB, CXCL16, PILRA, CD163, IGSF6
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
CREG1 25 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Regulates transcription in tethering assays (PMID: 9710587). Unlikely to be a TF, based on the lack of a canonical DBD
TNF 32 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The protein is a secreted cytokine and operates far upstream in the signaling cascade
ZFP36 33 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA binding protein (PMID: 10330172).
SGK1 42 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RB1 43 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Classic co-factor
PRDM1 46 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
IL10 69 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ICAM1 73 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZFP36L1 74 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 27102483; PMID: 17013884).
LGALS9 77 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SPI1 79 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MAFB 93 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence
CMKLR1 98 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a G protein-coupled receptor for the chemoattractant adipokine chemerin
NR4A2 101 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NFKBIA 104 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is I kappa B alpha, which interacts with NFkappaB. No DBD, and evidence indicates that it is not a TF.
NFKBIZ 106 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PYCARD 107 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PLEK 111 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs
TLR4 115 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HES1 118 Yes Known motif Monomer or homomultimer High-throughput in vitro None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T230_AGTTCCCCACTACACA-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.21 2249.28
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.45, DC:monocyte-derived:anti-DC-SIGN_2h: 0.45, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.45, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.44, DC:monocyte-derived: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, DC:monocyte-derived:LPS: 0.43, DC:monocyte-derived:Galectin-1: 0.43, Monocyte:leukotriene_D4: 0.43
T230_CGTTAGATCGCCAGTG-1 Macrophage:monocyte-derived:M-CSF 0.18 1860.42
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived: 0.43, Macrophage:monocyte-derived:IFNa: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, DC:monocyte-derived:immature: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.41, DC:monocyte-derived:Galectin-1: 0.41
T230_CCTCATGGTACAGTAA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.23 1834.62
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg: 0.49, Monocyte:leukotriene_D4: 0.48, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.47, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.47, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46, Monocyte:anti-FcgRIIB: 0.46, Monocyte: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Macrophage:monocyte-derived: 0.46
T230_GTGCTGGAGCCAGTAG-1 Macrophage:monocyte-derived:M-CSF 0.20 1726.62
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.44, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, DC:monocyte-derived: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, DC:monocyte-derived:Galectin-1: 0.42, DC:monocyte-derived:AEC-conditioned: 0.41, Macrophage:Alveolar:B._anthacis_spores: 0.41
T230_CGATGGCTCTCCTGTG-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.19 1701.18
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Macrophage:monocyte-derived:M-CSF: 0.42, DC:monocyte-derived:AEC-conditioned: 0.41, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.41, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.41, DC:monocyte-derived:LPS: 0.41, DC:monocyte-derived: 0.41, DC:monocyte-derived:Galectin-1: 0.41, DC:monocyte-derived:antiCD40/VAF347: 0.41
T200_CCTTGTGAGTTACGGG-1 DC:monocyte-derived:AEC-conditioned 0.12 1476.10
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, Macrophage:monocyte-derived:S._aureus: 0.36, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.35, DC:monocyte-derived:anti-DC-SIGN_2h: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Macrophage:Alveolar:B._anthacis_spores: 0.35, DC:monocyte-derived:LPS: 0.35, Macrophage:monocyte-derived:M-CSF: 0.35, Macrophage:Alveolar: 0.35
T200_GTATTTCAGGCTCTAT-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.15 1320.30
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, DC:monocyte-derived:LPS: 0.38, Macrophage:monocyte-derived:IFNa: 0.38, DC:monocyte-derived:AEC-conditioned: 0.38, DC:monocyte-derived:Poly(IC): 0.38, Macrophage:monocyte-derived:M-CSF: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, Macrophage:monocyte-derived:S._aureus: 0.38, DC:monocyte-derived:Galectin-1: 0.38
T230_TGCGATAAGCCTCACG-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.23 1287.08
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, DC:monocyte-derived:LPS: 0.45, DC:monocyte-derived:Galectin-1: 0.44, Macrophage:monocyte-derived:IFNa: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, DC:monocyte-derived:Poly(IC): 0.44, DC:monocyte-derived:antiCD40/VAF347: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44
T200_AGTACTGTCCCGTTCA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.18 1272.21
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.45, Macrophage:monocyte-derived:M-CSF: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44, Monocyte:leukotriene_D4: 0.44, Monocyte:CD14+: 0.44, Monocyte:CD16-: 0.43, Monocyte:anti-FcgRIIB: 0.43, Monocyte:CD16+: 0.43, Monocyte: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43
T200_ACTGTGATCCTACTGC-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.20 1260.35
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:M-CSF: 0.46, Monocyte:leukotriene_D4: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Monocyte:anti-FcgRIIB: 0.45, DC:monocyte-derived:LPS: 0.45, Monocyte: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, DC:monocyte-derived:Galectin-1: 0.44
T200_TAACCAGCATGGGTTT-1 Monocyte:CD14+ 0.20 1250.60
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.45, Monocyte:leukotriene_D4: 0.44, Monocyte:anti-FcgRIIB: 0.44, Monocyte:CD14+: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, Monocyte:CD16-: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44, Monocyte: 0.43, Macrophage:monocyte-derived:IFNa: 0.43
T188_TTTCAGTGTAATGCGG-1 Macrophage:monocyte-derived:M-CSF 0.21 1236.46
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.41, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.41, Monocyte:leukotriene_D4: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.41, DC:monocyte-derived:AEC-conditioned: 0.41, Monocyte:CD16-: 0.4, Monocyte:anti-FcgRIIB: 0.4, Macrophage:monocyte-derived: 0.4
T200_TGTACAGCAACGACTT-1 Monocyte:CD16+ 0.19 1173.73
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.47, Macrophage:monocyte-derived:M-CSF: 0.47, Monocyte:leukotriene_D4: 0.47, Monocyte:CD16-: 0.47, Monocyte:CD14+: 0.47, Monocyte:anti-FcgRIIB: 0.46, Monocyte:CD16+: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46
T200_ATACTTCTCATTACCT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.21 1163.10
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Monocyte:leukotriene_D4: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44, DC:monocyte-derived:LPS: 0.43, Monocyte:anti-FcgRIIB: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Macrophage:monocyte-derived:IFNa: 0.43, DC:monocyte-derived:Poly(IC): 0.43
T200_TCACTCGCACTACCGG-1 Monocyte:CD14+ 0.18 1157.15
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.44, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, Monocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Monocyte:anti-FcgRIIB: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, Monocyte: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43
T188_ACGGTCGCAAATGGTA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.18 1149.55
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.4, DC:monocyte-derived:LPS: 0.4, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.4, Monocyte:leukotriene_D4: 0.4, DC:monocyte-derived:AEC-conditioned: 0.39
T230_ATGACCATCGATGCAT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.19 1127.27
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.46, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.46, Macrophage:monocyte-derived:IL-4/cntrl: 0.45, Macrophage:monocyte-derived:IL-4/TGFb: 0.45, DC:monocyte-derived:anti-DC-SIGN_2h: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Monocyte:leukotriene_D4: 0.45, Macrophage:monocyte-derived: 0.45
T200_AACAACCTCAGGAAGC-1 DC:monocyte-derived:AEC-conditioned 0.13 1084.17
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.4, Macrophage:monocyte-derived:IFNa: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, Monocyte:CD16-: 0.38, DC:monocyte-derived:LPS: 0.38, Monocyte:leukotriene_D4: 0.38, Macrophage:monocyte-derived:M-CSF: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, Pre-B_cell_CD34-: 0.38
T200_CGAGTGCGTAATGCGG-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.18 1043.37
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, Macrophage:monocyte-derived:IFNa: 0.43, DC:monocyte-derived:LPS: 0.43, Monocyte:anti-FcgRIIB: 0.43, DC:monocyte-derived:Galectin-1: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Monocyte:leukotriene_D4: 0.42
T200_AAGCCATCACTAACGT-1 Monocyte:CD16+ 0.18 1038.58
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.47, Macrophage:monocyte-derived:M-CSF: 0.46, Monocyte:leukotriene_D4: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Monocyte:anti-FcgRIIB: 0.45, Monocyte:CD16+: 0.45, Monocyte:CD16-: 0.45, Monocyte: 0.45, Monocyte:CD14+: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45
T188_TTAGGCATCACTACTT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.16 915.27
Raw ScoresMonocyte:leukotriene_D4: 0.41, Monocyte: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, Monocyte:anti-FcgRIIB: 0.4, DC:monocyte-derived:anti-DC-SIGN_2h: 0.4, Monocyte:CD16+: 0.4, Monocyte:CD14+: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:CD16-: 0.39
T200_CCGTGAGAGGCACAAC-1 DC:monocyte-derived:AEC-conditioned 0.13 907.71
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37, Monocyte:CD16-: 0.37, Monocyte:leukotriene_D4: 0.36, Monocyte:anti-FcgRIIB: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, Monocyte:CD16+: 0.36, Monocyte:CD14+: 0.36, Macrophage:monocyte-derived:IFNa: 0.36, Monocyte: 0.36
T200_TCGCTCAAGCGATGAC-1 Monocyte:CD16+ 0.19 905.50
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Monocyte:leukotriene_D4: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48, Macrophage:monocyte-derived:M-CSF: 0.48, Monocyte:anti-FcgRIIB: 0.47, Monocyte: 0.47, DC:monocyte-derived:AEC-conditioned: 0.47, Monocyte:CD16-: 0.47, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46
T200_GAAGGACAGGTATTGA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.22 883.21
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.47, Macrophage:monocyte-derived:M-CSF: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, DC:monocyte-derived:LPS: 0.45, Monocyte:leukotriene_D4: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, DC:monocyte-derived:Galectin-1: 0.45, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.45, Macrophage:monocyte-derived:IFNa: 0.45, Monocyte:anti-FcgRIIB: 0.44
T200_TCTCCGATCTGTCCCA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.19 881.91
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.41, Macrophage:monocyte-derived:IFNa: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, DC:monocyte-derived:LPS: 0.4, DC:monocyte-derived:Galectin-1: 0.4, Macrophage:Alveolar:B._anthacis_spores: 0.39, DC:monocyte-derived:Poly(IC): 0.39, DC:monocyte-derived:AEC-conditioned: 0.39, Monocyte:leukotriene_D4: 0.39, Macrophage:Alveolar: 0.39
T200_CCTAAGACACGACGTC-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.20 866.85
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:M-CSF: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.44, Macrophage:monocyte-derived:IFNa: 0.44, DC:monocyte-derived:LPS: 0.44, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.44, DC:monocyte-derived:immature: 0.44, Monocyte:leukotriene_D4: 0.44, DC:monocyte-derived:Galectin-1: 0.44
T188_TTCGATTCAATCAGCT-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.18 842.60
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, Monocyte:leukotriene_D4: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42, Monocyte:CD16-: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, Monocyte: 0.42, Monocyte:anti-FcgRIIB: 0.42
T188_CAGTGCGAGCCTGACC-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.16 798.78
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.41, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, DC:monocyte-derived: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.4, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, Macrophage:Alveolar:B._anthacis_spores: 0.4
T200_GGGTGTCTCTTTCAGT-1 DC:monocyte-derived:AEC-conditioned 0.16 775.13
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:M-CSF: 0.45, Monocyte:leukotriene_D4: 0.45, Monocyte:CD16-: 0.45, Monocyte:CD16+: 0.45, Monocyte:CD14+: 0.45, DC:monocyte-derived:AEC-conditioned: 0.44, Monocyte:anti-FcgRIIB: 0.44, Monocyte: 0.44, DC:monocyte-derived:anti-DC-SIGN_2h: 0.44
T200_AATCACGGTGAGAGGG-1 Macrophage:monocyte-derived:M-CSF 0.19 760.60
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:leukotriene_D4: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Monocyte:anti-FcgRIIB: 0.46, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.45, Monocyte: 0.45, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.45, Macrophage:monocyte-derived: 0.45, Monocyte:CD16-: 0.45
T200_ATCACAGCAGCACAGA-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.22 754.86
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.49, Macrophage:monocyte-derived:M-CSF: 0.49, DC:monocyte-derived:LPS: 0.49, DC:monocyte-derived:AEC-conditioned: 0.48, Macrophage:monocyte-derived:S._aureus: 0.48, DC:monocyte-derived:Galectin-1: 0.48, Monocyte:leukotriene_D4: 0.48, Macrophage:monocyte-derived:IFNa: 0.48, Macrophage:Alveolar:B._anthacis_spores: 0.48
T188_GAGTCTAAGGCACTCC-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.18 751.38
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.41, Monocyte:leukotriene_D4: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.41, DC:monocyte-derived:AEC-conditioned: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.4, Monocyte: 0.4, DC:monocyte-derived:LPS: 0.4
T214_TCAAGACGTGTCACAT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.21 725.83
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Macrophage:monocyte-derived:IL-4/cntrl: 0.43, Macrophage:monocyte-derived:IL-4/TGFb: 0.43, DC:monocyte-derived: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Monocyte:leukotriene_D4: 0.42, DC:monocyte-derived:AEC-conditioned: 0.42
T200_CCCTGATGTGGCCCAT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.19 716.66
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:M-CSF: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.44, Monocyte:anti-FcgRIIB: 0.44, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.44, DC:monocyte-derived:immature: 0.44, DC:monocyte-derived:LPS: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43
T200_TGCATGATCTGTTGGA-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.09 712.98
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.31, Macrophage:monocyte-derived:M-CSF: 0.31, Macrophage:monocyte-derived:M-CSF/IFNg: 0.31, DC:monocyte-derived:AEC-conditioned: 0.31, Monocyte:CD16-: 0.31, Macrophage:monocyte-derived:IFNa: 0.31, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.3, Monocyte:anti-FcgRIIB: 0.3, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.3, Monocyte:CD14+: 0.3
T188_TGCACGGCAAAGCACG-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.19 676.97
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Monocyte:leukotriene_D4: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, DC:monocyte-derived:AEC-conditioned: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Monocyte: 0.41, Monocyte:CD16-: 0.41
T200_AATCACGGTGTCGATT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.22 676.95
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Macrophage:monocyte-derived:M-CSF: 0.46, Monocyte:leukotriene_D4: 0.46, Monocyte:anti-FcgRIIB: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Macrophage:monocyte-derived:IFNa: 0.45, Monocyte: 0.45, Monocyte:CD16-: 0.45, DC:monocyte-derived:LPS: 0.45
T214_AGTTAGCAGCACACCC-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.17 674.09
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, DC:monocyte-derived: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Macrophage:monocyte-derived:IL-4/TGFb: 0.41, Macrophage:monocyte-derived:IL-4/cntrl: 0.41, DC:monocyte-derived:AEC-conditioned: 0.4, Monocyte:leukotriene_D4: 0.4
T200_CAGGTATTCAACACCA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.19 661.74
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:leukotriene_D4: 0.46, Macrophage:monocyte-derived:M-CSF: 0.46, DC:monocyte-derived:AEC-conditioned: 0.45, Monocyte:anti-FcgRIIB: 0.45, Monocyte:CD16-: 0.45, Monocyte:CD16+: 0.45, Monocyte: 0.45, Monocyte:CD14+: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45
T200_TAAGTCGAGACGGATC-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.22 657.18
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:leukotriene_D4: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:anti-FcgRIIB: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Monocyte:CD16-: 0.45, Monocyte: 0.45, DC:monocyte-derived:LPS: 0.45, DC:monocyte-derived:anti-DC-SIGN_2h: 0.44
T200_CTGAGGCAGCTTCTAG-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.15 648.50
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.38, DC:monocyte-derived:AEC-conditioned: 0.38, Monocyte:leukotriene_D4: 0.38, Macrophage:monocyte-derived:M-CSF: 0.37, Monocyte:CD14+: 0.37, Monocyte:anti-FcgRIIB: 0.37, Monocyte:CD16-: 0.37, DC:monocyte-derived:anti-DC-SIGN_2h: 0.37, Monocyte: 0.37, Monocyte:CD16+: 0.37
T200_ATCCTATCATAGGTTC-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.20 644.29
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Macrophage:monocyte-derived:M-CSF: 0.47, DC:monocyte-derived:LPS: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Monocyte:anti-FcgRIIB: 0.46, Monocyte:leukotriene_D4: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Monocyte: 0.45, DC:monocyte-derived:Galectin-1: 0.45, DC:monocyte-derived:Poly(IC): 0.45
T188_AGTTAGCGTCCGAAGA-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.18 637.88
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, DC:monocyte-derived:AEC-conditioned: 0.42, Monocyte:leukotriene_D4: 0.41, DC:monocyte-derived:LPS: 0.41, DC:monocyte-derived: 0.41
T200_ACCTGAAAGGGTGAGG-1 DC:monocyte-derived:AEC-conditioned 0.14 636.86
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.36, Monocyte:CD16-: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, DC:monocyte-derived:anti-DC-SIGN_2h: 0.36, Monocyte:leukotriene_D4: 0.36, Monocyte:CD14+: 0.36, DC:monocyte-derived:LPS: 0.35, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.35, Monocyte:CD16+: 0.35
T200_GGTGTCGTCCTTTGAT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.23 634.52
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.49, DC:monocyte-derived:Poly(IC): 0.48, Macrophage:monocyte-derived:M-CSF: 0.48, DC:monocyte-derived:LPS: 0.48, DC:monocyte-derived:AEC-conditioned: 0.47, Macrophage:monocyte-derived:IFNa: 0.47, DC:monocyte-derived:Galectin-1: 0.47, Monocyte:anti-FcgRIIB: 0.47, Monocyte:leukotriene_D4: 0.47
T200_GTGAGTTGTACTGCGC-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.20 632.72
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.49, Macrophage:monocyte-derived:M-CSF: 0.48, Monocyte:leukotriene_D4: 0.47, Monocyte:CD16-: 0.47, Monocyte:anti-FcgRIIB: 0.47, DC:monocyte-derived:AEC-conditioned: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:CD16+: 0.46, Monocyte:CD14+: 0.46, Monocyte: 0.46
T200_TCAAGTGGTGATGGCA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.21 627.70
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg: 0.48, Monocyte:leukotriene_D4: 0.48, DC:monocyte-derived:AEC-conditioned: 0.47, Monocyte:anti-FcgRIIB: 0.47, Monocyte: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46, DC:monocyte-derived:Poly(IC): 0.45, DC:monocyte-derived:LPS: 0.45
T200_GGGTGAATCCGACATA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.17 615.47
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Monocyte:leukotriene_D4: 0.44, DC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.43, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.43, Monocyte: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Monocyte:CD16+: 0.42, Monocyte:CD16-: 0.42
T200_CTCAGAATCCGATTAG-1 Monocyte:CD16+ 0.11 592.46
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.35, DC:monocyte-derived:AEC-conditioned: 0.34, Macrophage:monocyte-derived:M-CSF: 0.34, Monocyte:leukotriene_D4: 0.34, DC:monocyte-derived:LPS: 0.34, DC:monocyte-derived:anti-DC-SIGN_2h: 0.34, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.33, Macrophage:monocyte-derived:IFNa: 0.33, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.33, DC:monocyte-derived:Poly(IC): 0.33
T200_ACTGTGACATAGCACT-1 DC:monocyte-derived:AEC-conditioned 0.15 586.31
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:M-CSF: 0.39, DC:monocyte-derived:LPS: 0.38, Macrophage:monocyte-derived:IFNa: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, Monocyte:leukotriene_D4: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, Monocyte:anti-FcgRIIB: 0.38, Macrophage:Alveolar:B._anthacis_spores: 0.38


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.86e-06
Mean rank of genes in gene set: 1223.36
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD14 0.0043031 14 GTEx DepMap Descartes 9.04 1277.56
CXCL16 0.0036238 27 GTEx DepMap Descartes 2.07 209.99
TNF 0.0035490 32 GTEx DepMap Descartes 1.49 195.94
TLR4 0.0021696 115 GTEx DepMap Descartes 0.39 6.84
IL18 0.0018670 164 GTEx DepMap Descartes 1.80 211.35
IL1B 0.0013639 250 GTEx DepMap Descartes 9.53 1238.66
CCL2 0.0008576 443 GTEx DepMap Descartes 2.65 653.02
CD80 0.0006457 589 GTEx DepMap Descartes 0.12 8.00
ITGAX 0.0003408 997 GTEx DepMap Descartes 0.53 23.91
IL33 -0.0000534 4766 GTEx DepMap Descartes 0.01 0.29
CCL5 -0.0000875 6060 GTEx DepMap Descartes 0.82 154.78


Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.11e-04
Mean rank of genes in gene set: 3602.04
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
C3 0.0028644 57 GTEx DepMap Descartes 0.97 46.76
IL10 0.0027023 69 GTEx DepMap Descartes 0.88 90.70
SERPING1 0.0020210 142 GTEx DepMap Descartes 1.14 111.02
CXCL2 0.0017998 176 GTEx DepMap Descartes 6.63 1340.59
IGF1 0.0014935 224 GTEx DepMap Descartes 0.56 19.37
CFD 0.0014003 240 GTEx DepMap Descartes 2.48 410.91
CXCL12 0.0013796 245 GTEx DepMap Descartes 0.49 35.14
SOD2 0.0012218 286 GTEx DepMap Descartes 4.65 73.95
CCL2 0.0008576 443 GTEx DepMap Descartes 2.65 653.02
PDPN 0.0003735 939 GTEx DepMap Descartes 0.10 8.72
GPX3 0.0001838 1430 GTEx DepMap Descartes 0.18 22.03
CFB 0.0001066 1791 GTEx DepMap Descartes 0.01 1.05
CXCL14 -0.0000380 4210 GTEx DepMap Descartes 0.02 1.71
LIF -0.0000469 4547 GTEx DepMap Descartes 0.01 1.11
HGF -0.0000523 4732 GTEx DepMap Descartes 0.17 5.01
IL33 -0.0000534 4766 GTEx DepMap Descartes 0.01 0.29
PDGFRB -0.0000645 5169 GTEx DepMap Descartes 0.05 1.56
SCARA5 -0.0000759 5634 GTEx DepMap Descartes 0.00 0.12
IGFBP6 -0.0000774 5690 GTEx DepMap Descartes 0.25 49.17
C7 -0.0000903 6171 GTEx DepMap Descartes 0.01 0.34
SCARA3 -0.0001113 7027 GTEx DepMap Descartes 0.01 0.37
PDGFD -0.0001345 7826 GTEx DepMap Descartes 0.00 0.15
RGMA -0.0001491 8306 GTEx DepMap Descartes 0.02 0.30
PDGFRA -0.0001933 9513 GTEx DepMap Descartes 0.05 1.37
IL1R1 -0.0002361 10418 GTEx DepMap Descartes 0.03 1.14


M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.38e-04
Mean rank of genes in gene set: 3164.27
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD14 0.0043031 14 GTEx DepMap Descartes 9.04 1277.56
TNF 0.0035490 32 GTEx DepMap Descartes 1.49 195.94
IL10 0.0027023 69 GTEx DepMap Descartes 0.88 90.70
CD84 0.0017730 179 GTEx DepMap Descartes 0.91 23.28
IL1B 0.0013639 250 GTEx DepMap Descartes 9.53 1238.66
HIF1A 0.0009972 372 GTEx DepMap Descartes 1.05 62.77
TGFB1 0.0005031 741 GTEx DepMap Descartes 0.88 70.32
CD274 0.0004438 818 GTEx DepMap Descartes 0.06 3.72
TNFRSF10B 0.0000129 2747 GTEx DepMap Descartes 0.19 9.61
ARG1 -0.0000095 3256 GTEx DepMap Descartes 0.00 0.00
NOS2 -0.0000118 3323 GTEx DepMap Descartes 0.00 0.00
CD36 -0.0000380 4211 GTEx DepMap Descartes 0.71 24.74
VEGFA -0.0001946 9544 GTEx DepMap Descartes 0.45 8.26
ARG2 -0.0002384 10456 GTEx DepMap Descartes 0.06 6.47
STAT3 -0.0003216 11452 GTEx DepMap Descartes 0.77 30.82




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10399.42
Median rank of genes in gene set: 11326
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LYN 0.0021492 119 GTEx DepMap Descartes 1.03 38.78
GLRX 0.0012211 287 GTEx DepMap Descartes 1.78 107.50
UCP2 0.0009370 403 GTEx DepMap Descartes 2.25 226.55
CXCR4 0.0006011 625 GTEx DepMap Descartes 3.38 436.58
DAPK1 0.0004936 754 GTEx DepMap Descartes 0.32 10.94
ST3GAL6 0.0003665 952 GTEx DepMap Descartes 0.29 18.16
CELF2 0.0002900 1112 GTEx DepMap Descartes 0.64 18.48
MYO5A 0.0001770 1458 GTEx DepMap Descartes 0.23 4.33
ATP6V1B2 0.0001506 1565 GTEx DepMap Descartes 0.96 27.89
ARL6IP1 0.0000734 2030 GTEx DepMap Descartes 1.36 127.02
AP1S2 0.0000730 2034 GTEx DepMap Descartes 1.29 80.45
NFIL3 -0.0000298 3940 GTEx DepMap Descartes 0.35 38.50
ANP32A -0.0000300 3948 GTEx DepMap Descartes 0.86 47.00
TIAM1 -0.0000521 4720 GTEx DepMap Descartes 0.09 2.73
EML4 -0.0000568 4893 GTEx DepMap Descartes 0.36 13.96
GLDC -0.0000612 5055 GTEx DepMap Descartes 0.01 0.17
SETD7 -0.0000638 5149 GTEx DepMap Descartes 0.10 2.96
INO80C -0.0000660 5240 GTEx DepMap Descartes 0.16 11.04
RBBP8 -0.0000701 5398 GTEx DepMap Descartes 0.11 6.24
BEND4 -0.0000709 5437 GTEx DepMap Descartes 0.00 0.11
SHC3 -0.0000713 5449 GTEx DepMap Descartes 0.01 0.09
STRA6 -0.0000892 6129 GTEx DepMap Descartes 0.01 0.32
POPDC3 -0.0000938 6311 GTEx DepMap Descartes 0.01 0.69
TBC1D30 -0.0001052 6787 GTEx DepMap Descartes 0.03 0.75
RET -0.0001092 6953 GTEx DepMap Descartes 0.02 0.43
ESRRG -0.0001098 6973 GTEx DepMap Descartes 0.01 0.28
FAM167A -0.0001128 7074 GTEx DepMap Descartes 0.01 0.36
LEPROTL1 -0.0001153 7169 GTEx DepMap Descartes 0.79 52.37
PRIM1 -0.0001198 7334 GTEx DepMap Descartes 0.08 8.65
DIABLO -0.0001218 7402 GTEx DepMap Descartes 0.03 1.70


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.58e-14
Mean rank of genes in gene set: 4997.63
Median rank of genes in gene set: 4439
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOE 0.0048557 4 GTEx DepMap Descartes 111.84 19982.59
CTSC 0.0045505 8 GTEx DepMap Descartes 6.69 215.02
GRN 0.0044949 10 GTEx DepMap Descartes 9.02 866.07
ITM2B 0.0041823 17 GTEx DepMap Descartes 13.56 309.41
NPC2 0.0038508 20 GTEx DepMap Descartes 10.69 1683.04
CREG1 0.0037000 25 GTEx DepMap Descartes 3.29 354.41
B2M 0.0033605 39 GTEx DepMap Descartes 118.31 10721.59
HNMT 0.0032551 41 GTEx DepMap Descartes 1.20 85.77
SGK1 0.0032475 42 GTEx DepMap Descartes 4.09 168.95
ZFP36L1 0.0025804 74 GTEx DepMap Descartes 3.85 295.58
RGS10 0.0023662 88 GTEx DepMap Descartes 3.65 889.13
HEXB 0.0023294 91 GTEx DepMap Descartes 1.30 144.35
PLXDC2 0.0023234 92 GTEx DepMap Descartes 0.70 13.47
PPT1 0.0022898 99 GTEx DepMap Descartes 1.82 99.82
HES1 0.0021535 118 GTEx DepMap Descartes 1.53 183.77
KLF4 0.0020708 134 GTEx DepMap Descartes 2.06 168.74
LIPA 0.0020651 136 GTEx DepMap Descartes 3.38 279.58
IL13RA1 0.0019951 147 GTEx DepMap Descartes 0.54 30.87
PLSCR1 0.0019809 149 GTEx DepMap Descartes 1.38 151.99
KCTD12 0.0019109 159 GTEx DepMap Descartes 0.80 29.97
SH3BGRL 0.0017051 191 GTEx DepMap Descartes 2.12 263.39
CD63 0.0016051 207 GTEx DepMap Descartes 11.43 2013.84
TNFRSF1A 0.0016030 208 GTEx DepMap Descartes 0.66 69.53
SDCBP 0.0015003 223 GTEx DepMap Descartes 3.20 186.59
CMTM6 0.0014183 237 GTEx DepMap Descartes 1.50 103.22
IFITM3 0.0013924 242 GTEx DepMap Descartes 7.00 2137.27
DSE 0.0013894 243 GTEx DepMap Descartes 0.46 10.55
CXCL12 0.0013796 245 GTEx DepMap Descartes 0.49 35.14
KLF6 0.0013431 256 GTEx DepMap Descartes 6.67 357.31
A2M 0.0013324 258 GTEx DepMap Descartes 1.40 68.93


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 7469.83
Median rank of genes in gene set: 8461.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOC1 0.0027202 68 GTEx DepMap Descartes 42.58 12007.64
NPC1 0.0003540 970 GTEx DepMap Descartes 0.13 5.47
SCARB1 0.0002575 1198 GTEx DepMap Descartes 0.20 7.28
POR 0.0001358 1630 GTEx DepMap Descartes 0.38 32.09
SH3PXD2B 0.0000554 2186 GTEx DepMap Descartes 0.06 1.80
ERN1 0.0000020 2953 GTEx DepMap Descartes 0.31 8.17
GRAMD1B -0.0000140 3412 GTEx DepMap Descartes 0.05 1.15
BAIAP2L1 -0.0000155 3452 GTEx DepMap Descartes 0.00 0.10
CYB5B -0.0000339 4090 GTEx DepMap Descartes 0.23 11.53
INHA -0.0000404 4318 GTEx DepMap Descartes 0.00 0.28
STAR -0.0000421 4386 GTEx DepMap Descartes 0.00 0.22
FDXR -0.0000659 5235 GTEx DepMap Descartes 0.08 6.13
FDX1 -0.0000730 5511 GTEx DepMap Descartes 0.50 31.75
FREM2 -0.0000732 5517 GTEx DepMap Descartes 0.00 0.01
SGCZ -0.0001016 6631 GTEx DepMap Descartes 0.00 0.00
SCAP -0.0001137 7110 GTEx DepMap Descartes 0.11 4.64
SLC16A9 -0.0001410 8057 GTEx DepMap Descartes 0.02 0.96
FRMD5 -0.0001451 8185 GTEx DepMap Descartes 0.01 0.21
DHCR24 -0.0001627 8738 GTEx DepMap Descartes 0.02 0.76
DHCR7 -0.0001717 8961 GTEx DepMap Descartes 0.06 4.36
PDE10A -0.0001889 9406 GTEx DepMap Descartes 0.02 0.31
MSMO1 -0.0002085 9879 GTEx DepMap Descartes 0.07 7.20
HMGCS1 -0.0002181 10085 GTEx DepMap Descartes 0.13 5.19
PAPSS2 -0.0002226 10180 GTEx DepMap Descartes 0.17 7.81
SLC1A2 -0.0002389 10465 GTEx DepMap Descartes 0.03 0.34
HMGCR -0.0002428 10530 GTEx DepMap Descartes 0.08 3.44
DNER -0.0002599 10783 GTEx DepMap Descartes 0.02 1.01
TM7SF2 -0.0002658 10877 GTEx DepMap Descartes 0.10 9.19
IGF1R -0.0002777 11049 GTEx DepMap Descartes 0.06 0.85
PEG3 -0.0003382 11580 GTEx DepMap Descartes 0.05 NA


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10785.61
Median rank of genes in gene set: 11594
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EPHA6 -0.0001009 6604 GTEx DepMap Descartes 0.01 0.23
RPH3A -0.0001131 7086 GTEx DepMap Descartes 0.01 0.60
ANKFN1 -0.0001251 7517 GTEx DepMap Descartes 0.00 0.13
SLC44A5 -0.0001321 7732 GTEx DepMap Descartes 0.01 0.47
GREM1 -0.0001407 8043 GTEx DepMap Descartes 0.01 0.09
ALK -0.0001479 8262 GTEx DepMap Descartes 0.02 0.58
HS3ST5 -0.0001516 8398 GTEx DepMap Descartes 0.01 0.52
FAT3 -0.0001707 8932 GTEx DepMap Descartes 0.02 0.12
KCNB2 -0.0001772 9114 GTEx DepMap Descartes 0.01 0.56
RYR2 -0.0001892 9416 GTEx DepMap Descartes 0.02 0.14
EYA1 -0.0002052 9790 GTEx DepMap Descartes 0.02 0.89
EYA4 -0.0002103 9915 GTEx DepMap Descartes 0.02 0.34
PTCHD1 -0.0002142 9998 GTEx DepMap Descartes 0.01 0.08
CNKSR2 -0.0002224 10176 GTEx DepMap Descartes 0.02 0.23
PLXNA4 -0.0002353 10411 GTEx DepMap Descartes 0.03 0.41
TMEM132C -0.0002360 10417 GTEx DepMap Descartes 0.01 0.39
SLC6A2 -0.0002416 10515 GTEx DepMap Descartes 0.03 1.07
SYNPO2 -0.0002651 10865 GTEx DepMap Descartes 0.08 0.78
TMEFF2 -0.0003040 11309 GTEx DepMap Descartes 0.05 2.59
RBFOX1 -0.0003268 11493 GTEx DepMap Descartes 0.02 0.72
REEP1 -0.0003396 11594 GTEx DepMap Descartes 0.05 1.95
NTRK1 -0.0003417 11607 GTEx DepMap Descartes 0.07 3.45
RGMB -0.0003630 11739 GTEx DepMap Descartes 0.07 2.70
IL7 -0.0003687 11779 GTEx DepMap Descartes 0.05 4.99
GAL -0.0003799 11841 GTEx DepMap Descartes 0.18 41.08
NPY -0.0004373 12114 GTEx DepMap Descartes 2.88 579.07
MAB21L2 -0.0004449 12135 GTEx DepMap Descartes 0.12 5.85
CNTFR -0.0004473 12142 GTEx DepMap Descartes 0.11 8.29
MAB21L1 -0.0004604 12174 GTEx DepMap Descartes 0.14 7.14
ELAVL2 -0.0004776 12210 GTEx DepMap Descartes 0.11 4.17


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 7893.74
Median rank of genes in gene set: 8096.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CRHBP 0.0011931 298 GTEx DepMap Descartes 0.10 13.02
NR5A2 0.0000913 1906 GTEx DepMap Descartes 0.00 0.06
F8 0.0000678 2072 GTEx DepMap Descartes 0.02 0.47
NPR1 -0.0000166 3486 GTEx DepMap Descartes 0.00 0.19
CEACAM1 -0.0000179 3529 GTEx DepMap Descartes 0.01 0.70
ESM1 -0.0000334 4072 GTEx DepMap Descartes 0.03 1.00
TMEM88 -0.0000350 4130 GTEx DepMap Descartes 0.14 34.73
BTNL9 -0.0000447 4464 GTEx DepMap Descartes 0.01 0.21
CLDN5 -0.0000653 5204 GTEx DepMap Descartes 0.08 5.84
SHANK3 -0.0000797 5769 GTEx DepMap Descartes 0.01 0.16
ROBO4 -0.0000961 6387 GTEx DepMap Descartes 0.02 0.50
EHD3 -0.0001022 6653 GTEx DepMap Descartes 0.01 0.15
CDH13 -0.0001101 6985 GTEx DepMap Descartes 0.01 0.15
IRX3 -0.0001165 7218 GTEx DepMap Descartes 0.01 0.64
RASIP1 -0.0001197 7328 GTEx DepMap Descartes 0.02 0.75
SHE -0.0001235 7458 GTEx DepMap Descartes 0.01 0.49
KANK3 -0.0001331 7778 GTEx DepMap Descartes 0.01 0.44
MYRIP -0.0001334 7788 GTEx DepMap Descartes 0.01 0.14
CYP26B1 -0.0001386 7957 GTEx DepMap Descartes 0.01 0.36
FLT4 -0.0001470 8236 GTEx DepMap Descartes 0.01 0.10
GALNT15 -0.0001557 8508 GTEx DepMap Descartes 0.01 NA
CALCRL -0.0001813 9235 GTEx DepMap Descartes 0.02 0.48
CDH5 -0.0001829 9275 GTEx DepMap Descartes 0.03 0.68
NOTCH4 -0.0001921 9496 GTEx DepMap Descartes 0.07 1.93
KDR -0.0001944 9538 GTEx DepMap Descartes 0.02 0.28
TEK -0.0002037 9737 GTEx DepMap Descartes 0.01 0.14
TIE1 -0.0002140 9990 GTEx DepMap Descartes 0.01 0.39
CHRM3 -0.0002158 10029 GTEx DepMap Descartes 0.04 0.67
MMRN2 -0.0002450 10566 GTEx DepMap Descartes 0.02 0.53
PLVAP -0.0002566 10754 GTEx DepMap Descartes 0.07 4.85


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.14e-01
Mean rank of genes in gene set: 5843.3
Median rank of genes in gene set: 5528.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IGFBP3 0.0001271 1679 GTEx DepMap Descartes 0.04 1.98
ABCC9 0.0000376 2387 GTEx DepMap Descartes 0.01 0.10
PAMR1 0.0000152 2708 GTEx DepMap Descartes 0.03 2.08
FREM1 -0.0000100 3272 GTEx DepMap Descartes 0.01 0.15
ADAMTSL3 -0.0000169 3493 GTEx DepMap Descartes 0.00 0.11
ITGA11 -0.0000275 3858 GTEx DepMap Descartes 0.00 0.06
COL27A1 -0.0000298 3938 GTEx DepMap Descartes 0.01 0.21
GLI2 -0.0000314 3997 GTEx DepMap Descartes 0.00 0.00
LOX -0.0000315 4001 GTEx DepMap Descartes 0.01 0.56
GAS2 -0.0000381 4217 GTEx DepMap Descartes 0.00 0.20
ACTA2 -0.0000388 4249 GTEx DepMap Descartes 0.09 14.07
POSTN -0.0000399 4297 GTEx DepMap Descartes 0.01 0.75
LAMC3 -0.0000453 4486 GTEx DepMap Descartes 0.00 0.00
COL3A1 -0.0000485 4606 GTEx DepMap Descartes 0.24 10.07
PCDH18 -0.0000536 4767 GTEx DepMap Descartes 0.01 0.24
SFRP2 -0.0000573 4908 GTEx DepMap Descartes 0.00 0.00
COL12A1 -0.0000575 4918 GTEx DepMap Descartes 0.01 0.24
ABCA6 -0.0000612 5054 GTEx DepMap Descartes 0.07 2.18
OGN -0.0000634 5132 GTEx DepMap Descartes 0.03 2.21
CCDC80 -0.0000721 5479 GTEx DepMap Descartes 0.03 0.56
DKK2 -0.0000724 5489 GTEx DepMap Descartes 0.01 0.73
LRRC17 -0.0000725 5495 GTEx DepMap Descartes 0.01 0.88
ISLR -0.0000742 5562 GTEx DepMap Descartes 0.03 3.17
COL1A1 -0.0000747 5580 GTEx DepMap Descartes 0.31 12.11
SCARA5 -0.0000759 5634 GTEx DepMap Descartes 0.00 0.12
COL6A3 -0.0000781 5716 GTEx DepMap Descartes 0.06 1.35
EDNRA -0.0000807 5807 GTEx DepMap Descartes 0.01 0.23
C7 -0.0000903 6171 GTEx DepMap Descartes 0.01 0.34
COL1A2 -0.0000909 6189 GTEx DepMap Descartes 0.28 10.85
RSPO3 -0.0000983 6475 GTEx DepMap Descartes 0.00 NA


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8272.58
Median rank of genes in gene set: 8233.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ST18 0.0000933 1892 GTEx DepMap Descartes 0.02 0.89
SLC35F3 -0.0000515 4695 GTEx DepMap Descartes 0.01 0.62
TIAM1 -0.0000521 4720 GTEx DepMap Descartes 0.09 2.73
GRM7 -0.0000636 5143 GTEx DepMap Descartes 0.00 0.01
TBX20 -0.0000722 5482 GTEx DepMap Descartes 0.00 0.00
LAMA3 -0.0000734 5526 GTEx DepMap Descartes 0.00 0.03
CNTN3 -0.0000740 5548 GTEx DepMap Descartes 0.00 0.14
SLC24A2 -0.0000820 5846 GTEx DepMap Descartes 0.00 0.00
SORCS3 -0.0000841 5914 GTEx DepMap Descartes 0.01 0.25
CDH12 -0.0000993 6523 GTEx DepMap Descartes 0.00 0.16
DGKK -0.0000996 6543 GTEx DepMap Descartes 0.01 0.21
TENM1 -0.0001014 6617 GTEx DepMap Descartes 0.01 NA
CDH18 -0.0001027 6682 GTEx DepMap Descartes 0.00 0.13
AGBL4 -0.0001045 6757 GTEx DepMap Descartes 0.01 0.52
PCSK2 -0.0001124 7063 GTEx DepMap Descartes 0.01 0.29
PENK -0.0001157 7187 GTEx DepMap Descartes 0.00 1.07
GALNTL6 -0.0001194 7315 GTEx DepMap Descartes 0.00 0.08
CCSER1 -0.0001234 7453 GTEx DepMap Descartes 0.03 NA
EML6 -0.0001337 7795 GTEx DepMap Descartes 0.01 0.09
GCH1 -0.0001605 8672 GTEx DepMap Descartes 0.24 17.00
GRID2 -0.0001630 8747 GTEx DepMap Descartes 0.02 0.30
PACRG -0.0001639 8775 GTEx DepMap Descartes 0.01 0.72
FGF14 -0.0001781 9140 GTEx DepMap Descartes 0.03 0.40
KSR2 -0.0001804 9209 GTEx DepMap Descartes 0.02 0.15
SPOCK3 -0.0001827 9270 GTEx DepMap Descartes 0.01 0.41
SLC18A1 -0.0002017 9696 GTEx DepMap Descartes 0.02 0.97
ROBO1 -0.0002096 9901 GTEx DepMap Descartes 0.05 1.26
NTNG1 -0.0002276 10267 GTEx DepMap Descartes 0.01 0.28
UNC80 -0.0002302 10312 GTEx DepMap Descartes 0.03 0.36
FAM155A -0.0002414 10507 GTEx DepMap Descartes 0.04 0.68


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.47e-02
Mean rank of genes in gene set: 4954.07
Median rank of genes in gene set: 4301
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BLVRB 0.0017028 192 GTEx DepMap Descartes 3.05 481.63
GYPC 0.0010043 368 GTEx DepMap Descartes 1.21 169.73
GCLC 0.0005269 710 GTEx DepMap Descartes 0.17 9.38
CAT 0.0004700 789 GTEx DepMap Descartes 0.49 43.64
MARCH3 0.0003619 959 GTEx DepMap Descartes 0.10 NA
SPECC1 0.0001538 1552 GTEx DepMap Descartes 0.12 3.02
CPOX 0.0000869 1933 GTEx DepMap Descartes 0.05 3.72
FECH 0.0000491 2250 GTEx DepMap Descartes 0.09 2.21
RGS6 0.0000307 2456 GTEx DepMap Descartes 0.00 0.07
RAPGEF2 0.0000256 2527 GTEx DepMap Descartes 0.19 4.93
SLC4A1 0.0000220 2586 GTEx DepMap Descartes 0.01 0.37
RHD -0.0000158 3464 GTEx DepMap Descartes 0.00 0.00
SLC25A21 -0.0000203 3614 GTEx DepMap Descartes 0.00 0.00
ABCB10 -0.0000338 4082 GTEx DepMap Descartes 0.04 2.18
ALAS2 -0.0000401 4301 GTEx DepMap Descartes 0.00 0.13
XPO7 -0.0000561 4871 GTEx DepMap Descartes 0.10 3.74
MICAL2 -0.0000680 5309 GTEx DepMap Descartes 0.02 0.93
TRAK2 -0.0000865 6015 GTEx DepMap Descartes 0.07 2.00
SELENBP1 -0.0000988 6500 GTEx DepMap Descartes 0.02 1.25
TMCC2 -0.0001067 6838 GTEx DepMap Descartes 0.01 0.45
SPTB -0.0001389 7965 GTEx DepMap Descartes 0.01 0.06
TFR2 -0.0001413 8063 GTEx DepMap Descartes 0.01 0.40
SNCA -0.0001524 8424 GTEx DepMap Descartes 0.23 16.08
DENND4A -0.0001595 8648 GTEx DepMap Descartes 0.15 3.81
ANK1 -0.0001753 9068 GTEx DepMap Descartes 0.01 0.13
SOX6 -0.0001764 9095 GTEx DepMap Descartes 0.01 0.16
SLC25A37 -0.0001842 9312 GTEx DepMap Descartes 0.24 12.04
EPB41 -0.0002008 9683 GTEx DepMap Descartes 0.14 4.34
TSPAN5 -0.0004314 12094 GTEx DepMap Descartes 0.09 3.25
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.37e-21
Mean rank of genes in gene set: 801.05
Median rank of genes in gene set: 136.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD74 0.0054301 2 GTEx DepMap Descartes 65.93 4913.08
CSF1R 0.0046462 5 GTEx DepMap Descartes 1.62 101.09
CTSC 0.0045505 8 GTEx DepMap Descartes 6.69 215.02
MS4A4A 0.0045325 9 GTEx DepMap Descartes 2.87 390.85
CD14 0.0043031 14 GTEx DepMap Descartes 9.04 1277.56
AXL 0.0038739 19 GTEx DepMap Descartes 0.97 48.90
SLCO2B1 0.0038006 22 GTEx DepMap Descartes 0.93 37.17
MSR1 0.0037970 23 GTEx DepMap Descartes 1.07 67.98
CYBB 0.0036684 26 GTEx DepMap Descartes 1.57 80.84
LGMN 0.0035878 29 GTEx DepMap Descartes 5.39 553.58
ADAP2 0.0035641 30 GTEx DepMap Descartes 1.12 100.05
CTSS 0.0035584 31 GTEx DepMap Descartes 6.40 319.89
CD163 0.0033668 37 GTEx DepMap Descartes 1.52 69.97
CPVL 0.0030611 49 GTEx DepMap Descartes 2.19 212.30
FGL2 0.0030344 50 GTEx DepMap Descartes 2.54 131.78
CST3 0.0027673 67 GTEx DepMap Descartes 21.88 1483.06
MARCH1 0.0023092 94 GTEx DepMap Descartes 0.73 NA
SLC1A3 0.0022314 108 GTEx DepMap Descartes 0.44 25.35
MERTK 0.0022066 113 GTEx DepMap Descartes 0.38 22.30
HCK 0.0019063 160 GTEx DepMap Descartes 0.70 66.23
SLC9A9 0.0017669 180 GTEx DepMap Descartes 0.28 19.23
FGD2 0.0013072 267 GTEx DepMap Descartes 0.20 7.60
TGFBI 0.0012802 273 GTEx DepMap Descartes 1.40 66.74
ATP8B4 0.0012625 281 GTEx DepMap Descartes 0.12 5.46
ABCA1 0.0011721 304 GTEx DepMap Descartes 0.92 19.84
PTPRE 0.0011296 319 GTEx DepMap Descartes 0.87 34.31
IFNGR1 0.0009707 383 GTEx DepMap Descartes 1.23 106.69
WWP1 0.0009606 390 GTEx DepMap Descartes 0.31 13.69
CTSB 0.0009181 413 GTEx DepMap Descartes 13.19 785.70
RGL1 0.0009077 418 GTEx DepMap Descartes 0.31 12.56


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 7217.02
Median rank of genes in gene set: 7453
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
KCTD12 0.0019109 159 GTEx DepMap Descartes 0.80 29.97
GAS7 0.0002968 1086 GTEx DepMap Descartes 0.22 6.19
STARD13 0.0002428 1243 GTEx DepMap Descartes 0.09 3.76
MARCKS 0.0002246 1293 GTEx DepMap Descartes 4.93 230.02
PTPRZ1 0.0000664 2081 GTEx DepMap Descartes 0.00 0.11
COL18A1 0.0000448 2294 GTEx DepMap Descartes 0.13 4.40
NRXN3 0.0000288 2480 GTEx DepMap Descartes 0.01 0.28
HMGA2 0.0000111 2776 GTEx DepMap Descartes 0.00 0.06
PAG1 -0.0000172 3502 GTEx DepMap Descartes 0.32 6.83
TRPM3 -0.0000224 3679 GTEx DepMap Descartes 0.00 0.03
MDGA2 -0.0000265 3827 GTEx DepMap Descartes 0.00 0.12
IL1RAPL2 -0.0000343 4105 GTEx DepMap Descartes 0.00 0.00
IL1RAPL1 -0.0000346 4120 GTEx DepMap Descartes 0.01 0.48
GRIK3 -0.0000696 5376 GTEx DepMap Descartes 0.01 0.21
PLCE1 -0.0000820 5844 GTEx DepMap Descartes 0.03 0.61
ERBB4 -0.0000824 5854 GTEx DepMap Descartes 0.01 0.17
COL25A1 -0.0000879 6075 GTEx DepMap Descartes 0.00 0.04
ERBB3 -0.0000950 6358 GTEx DepMap Descartes 0.03 1.04
XKR4 -0.0001006 6592 GTEx DepMap Descartes 0.01 0.17
LRRTM4 -0.0001145 7141 GTEx DepMap Descartes 0.01 0.26
EDNRB -0.0001164 7213 GTEx DepMap Descartes 0.06 3.35
LAMC1 -0.0001227 7432 GTEx DepMap Descartes 0.08 2.03
OLFML2A -0.0001240 7474 GTEx DepMap Descartes 0.03 0.63
SLC35F1 -0.0001307 7696 GTEx DepMap Descartes 0.02 0.59
COL5A2 -0.0001345 7822 GTEx DepMap Descartes 0.04 1.30
MPZ -0.0001466 8221 GTEx DepMap Descartes 0.10 13.03
EGFLAM -0.0001570 8562 GTEx DepMap Descartes 0.02 0.65
SORCS1 -0.0001597 8654 GTEx DepMap Descartes 0.03 0.70
FIGN -0.0001744 9040 GTEx DepMap Descartes 0.03 0.52
SCN7A -0.0002221 10167 GTEx DepMap Descartes 0.09 2.44


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.29e-02
Mean rank of genes in gene set: 5449.71
Median rank of genes in gene set: 5810
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLEK 0.0022170 111 GTEx DepMap Descartes 2.20 173.06
TMSB4X 0.0018485 167 GTEx DepMap Descartes 145.65 18449.07
CD84 0.0017730 179 GTEx DepMap Descartes 0.91 23.28
STOM 0.0011414 316 GTEx DepMap Descartes 0.62 41.55
FLI1 0.0008472 451 GTEx DepMap Descartes 0.18 8.12
FERMT3 0.0007206 531 GTEx DepMap Descartes 0.69 57.06
LIMS1 0.0005769 646 GTEx DepMap Descartes 1.58 75.37
PSTPIP2 0.0005299 702 GTEx DepMap Descartes 0.15 10.07
TGFB1 0.0005031 741 GTEx DepMap Descartes 0.88 70.32
MCTP1 0.0004334 827 GTEx DepMap Descartes 0.12 4.24
TLN1 0.0004117 861 GTEx DepMap Descartes 0.76 18.21
ZYX 0.0003620 958 GTEx DepMap Descartes 0.61 56.68
ARHGAP6 0.0000765 2003 GTEx DepMap Descartes 0.01 0.31
STON2 0.0000721 2039 GTEx DepMap Descartes 0.05 2.39
TRPC6 0.0000406 2341 GTEx DepMap Descartes 0.00 0.13
GP1BA 0.0000232 2569 GTEx DepMap Descartes 0.00 0.45
MMRN1 -0.0000104 3285 GTEx DepMap Descartes 0.01 0.13
GSN -0.0000439 4439 GTEx DepMap Descartes 1.59 50.52
MYH9 -0.0000532 4756 GTEx DepMap Descartes 0.42 11.48
SLC24A3 -0.0000539 4775 GTEx DepMap Descartes 0.00 0.13
UBASH3B -0.0000580 4937 GTEx DepMap Descartes 0.11 3.67
CD9 -0.0000639 5150 GTEx DepMap Descartes 1.15 136.65
ITGA2B -0.0000807 5810 GTEx DepMap Descartes 0.00 0.05
TUBB1 -0.0000860 5990 GTEx DepMap Descartes 0.00 0.00
P2RX1 -0.0000908 6184 GTEx DepMap Descartes 0.02 1.18
MED12L -0.0000931 6281 GTEx DepMap Descartes 0.01 0.09
ITGB3 -0.0001054 6792 GTEx DepMap Descartes 0.00 0.00
MYLK -0.0001111 7021 GTEx DepMap Descartes 0.02 0.33
THBS1 -0.0001153 7167 GTEx DepMap Descartes 0.14 4.05
RAB27B -0.0001277 7593 GTEx DepMap Descartes 0.01 0.31


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.38e-01
Mean rank of genes in gene set: 6187.86
Median rank of genes in gene set: 8038.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0033605 39 GTEx DepMap Descartes 118.31 10721.59
ARHGDIB 0.0010893 334 GTEx DepMap Descartes 4.40 793.63
SORL1 0.0009430 399 GTEx DepMap Descartes 0.45 9.82
SP100 0.0007845 493 GTEx DepMap Descartes 0.59 23.59
RCSD1 0.0006809 564 GTEx DepMap Descartes 0.36 16.12
PTPRC 0.0006271 604 GTEx DepMap Descartes 1.63 68.56
WIPF1 0.0006087 618 GTEx DepMap Descartes 0.75 35.90
ARHGAP15 0.0005531 678 GTEx DepMap Descartes 0.40 31.84
MBNL1 0.0004162 850 GTEx DepMap Descartes 0.61 20.96
PLEKHA2 0.0003838 916 GTEx DepMap Descartes 0.24 9.72
DOCK10 0.0003144 1047 GTEx DepMap Descartes 0.24 7.33
CELF2 0.0002900 1112 GTEx DepMap Descartes 0.64 18.48
LCP1 0.0002681 1171 GTEx DepMap Descartes 1.28 66.04
ANKRD44 0.0001931 1395 GTEx DepMap Descartes 0.25 7.86
MSN 0.0001806 1442 GTEx DepMap Descartes 0.85 46.71
IKZF1 0.0001744 1471 GTEx DepMap Descartes 0.31 11.31
PRKCH -0.0000578 4927 GTEx DepMap Descartes 0.07 4.09
ITPKB -0.0000676 5299 GTEx DepMap Descartes 0.06 2.22
SAMD3 -0.0000867 6021 GTEx DepMap Descartes 0.02 1.33
CCL5 -0.0000875 6060 GTEx DepMap Descartes 0.82 154.78
MCTP2 -0.0001276 7591 GTEx DepMap Descartes 0.01 0.38
SKAP1 -0.0001547 8486 GTEx DepMap Descartes 0.02 2.56
EVL -0.0001586 8617 GTEx DepMap Descartes 1.04 61.08
TMSB10 -0.0001615 8703 GTEx DepMap Descartes 54.17 23941.70
CCND3 -0.0001667 8831 GTEx DepMap Descartes 0.24 21.51
SCML4 -0.0001821 9258 GTEx DepMap Descartes 0.02 0.92
LEF1 -0.0001903 9455 GTEx DepMap Descartes 0.03 1.38
PDE3B -0.0001933 9514 GTEx DepMap Descartes 0.06 1.87
BCL2 -0.0002061 9817 GTEx DepMap Descartes 0.20 5.28
ETS1 -0.0002121 9958 GTEx DepMap Descartes 0.07 2.34


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.73e-04
Mean rank of genes in gene set: 167.25
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
APOE 0.0048557 4 GTEx DepMap Descartes 111.84 19982.59
APOC1 0.0027202 68 GTEx DepMap Descartes 42.58 12007.64
FTH1 0.0018037 174 GTEx DepMap Descartes 146.20 26052.21
CD5L 0.0008956 423 GTEx DepMap Descartes 0.97 110.91


Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.55e-03
Mean rank of genes in gene set: 89
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TYROBP 0.0045763 7 GTEx DepMap Descartes 24.57 9093.27
SAT1 0.0037539 24 GTEx DepMap Descartes 35.19 7055.67
NEAT1 0.0014314 236 GTEx DepMap Descartes 10.28 105.61


ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.49e-03
Mean rank of genes in gene set: 1079
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
LST1 0.0018036 175 GTEx DepMap Descartes 4.36 524.68
SCN1B 0.0005733 654 GTEx DepMap Descartes 0.14 7.12
HPN 0.0000351 2408 GTEx DepMap Descartes 0.01 0.70