Program: 4. M2 Macrophage.

Program: 4. M2 Macrophage.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program. Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret. The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program (currently only calculated for the cells in the first 50/50 split of the data). Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 LIPA 0.0106928 lipase A, lysosomal acid type GTEx DepMap Descartes 7.20 701.83
2 APOE 0.0095484 apolipoprotein E GTEx DepMap Descartes 34.27 7483.78
3 LGMN 0.0084108 legumain GTEx DepMap Descartes 7.74 951.93
4 CTSB 0.0081959 cathepsin B GTEx DepMap Descartes 24.48 1833.57
5 PSAP 0.0081839 prosaposin GTEx DepMap Descartes 44.86 3703.97
6 APOC1 0.0080386 apolipoprotein C1 GTEx DepMap Descartes 8.05 2748.16
7 CTSD 0.0080343 cathepsin D GTEx DepMap Descartes 19.69 2418.32
8 GPNMB 0.0078106 glycoprotein nmb GTEx DepMap Descartes 11.84 1032.70
9 SLC40A1 0.0076944 solute carrier family 40 member 1 GTEx DepMap Descartes 3.76 464.59
10 CD68 0.0075716 CD68 molecule GTEx DepMap Descartes 6.61 1049.94
11 CD163 0.0074670 CD163 molecule GTEx DepMap Descartes 4.24 245.25
12 SLCO2B1 0.0072832 solute carrier organic anion transporter family member 2B1 GTEx DepMap Descartes 2.32 130.09
13 CSF1R 0.0069906 colony stimulating factor 1 receptor GTEx DepMap Descartes 3.69 298.03
14 IGSF6 0.0066704 immunoglobulin superfamily member 6 GTEx DepMap Descartes 2.55 257.16
15 MS4A4A 0.0066294 membrane spanning 4-domains A4A GTEx DepMap Descartes 2.58 495.21
16 ASAH1 0.0066077 N-acylsphingosine amidohydrolase 1 GTEx DepMap Descartes 6.65 302.28
17 CD5L 0.0062905 CD5 molecule like GTEx DepMap Descartes 2.20 249.66
18 CTSS 0.0062604 cathepsin S GTEx DepMap Descartes 9.08 567.56
19 CD14 0.0061947 CD14 molecule GTEx DepMap Descartes 4.69 1018.07
20 GRN 0.0061328 granulin precursor GTEx DepMap Descartes 11.60 1336.07
21 C2 0.0059589 complement C2 GTEx DepMap Descartes 1.62 167.22
22 CPVL 0.0059359 carboxypeptidase vitellogenic like GTEx DepMap Descartes 3.99 467.94
23 TYROBP 0.0058975 transmembrane immune signaling adaptor TYROBP GTEx DepMap Descartes 14.30 6850.13
24 PLD3 0.0055671 phospholipase D family member 3 GTEx DepMap Descartes 4.00 557.29
25 CD74 0.0055652 CD74 molecule GTEx DepMap Descartes 174.08 14110.95
26 CD163L1 0.0055483 CD163 molecule like 1 GTEx DepMap Descartes 0.66 54.05
27 MRC1 0.0053636 mannose receptor C-type 1 GTEx DepMap Descartes 2.31 175.36
28 NPL 0.0053510 N-acetylneuraminate pyruvate lyase GTEx DepMap Descartes 1.39 148.66
29 NPC2 0.0051896 NPC intracellular cholesterol transporter 2 GTEx DepMap Descartes 6.10 1166.07
30 ADAP2 0.0051791 ArfGAP with dual PH domains 2 GTEx DepMap Descartes 1.43 204.01
31 FGL2 0.0050760 fibrinogen like 2 GTEx DepMap Descartes 6.40 400.16
32 AIF1 0.0048874 allograft inflammatory factor 1 GTEx DepMap Descartes 3.18 726.55
33 FUCA1 0.0048867 alpha-L-fucosidase 1 GTEx DepMap Descartes 1.27 170.55
34 CYBB 0.0048465 cytochrome b-245 beta chain GTEx DepMap Descartes 3.33 209.94
35 ACP5 0.0048350 acid phosphatase 5, tartrate resistant GTEx DepMap Descartes 1.27 147.24
36 CTSC 0.0048188 cathepsin C GTEx DepMap Descartes 4.31 237.27
37 CD4 0.0046277 CD4 molecule GTEx DepMap Descartes 5.75 446.65
38 FCGRT 0.0046043 Fc gamma receptor and transporter GTEx DepMap Descartes 4.54 549.81
39 PLA2G7 0.0045287 phospholipase A2 group VII GTEx DepMap Descartes 1.55 176.12
40 TMEM37 0.0044583 transmembrane protein 37 GTEx DepMap Descartes 0.30 53.46
41 CD84 0.0042484 CD84 molecule GTEx DepMap Descartes 3.49 133.38
42 GM2A 0.0041844 GM2 ganglioside activator GTEx DepMap Descartes 3.20 195.03
43 MFSD1 0.0041332 major facilitator superfamily domain containing 1 GTEx DepMap Descartes 2.10 252.80
44 IL18 0.0041192 interleukin 18 GTEx DepMap Descartes 1.61 240.07
45 CREG1 0.0040593 cellular repressor of E1A stimulated genes 1 GTEx DepMap Descartes 4.39 532.32
46 MSR1 0.0040519 macrophage scavenger receptor 1 GTEx DepMap Descartes 2.37 226.77
47 MERTK 0.0039596 MER proto-oncogene, tyrosine kinase GTEx DepMap Descartes 0.54 35.26
48 TPP1 0.0039374 tripeptidyl peptidase 1 GTEx DepMap Descartes 5.63 297.03
49 LAIR1 0.0037938 leukocyte associated immunoglobulin like receptor 1 GTEx DepMap Descartes 1.77 94.77
50 SLAMF8 0.0037766 SLAM family member 8 GTEx DepMap Descartes 0.46 41.77


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UMAP plots showing activity of gene expression program identified in community:4. M2 Macrophage

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 4. M2 Macrophage:
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 2.84e-55 185.86 94.91 1.90e-52 1.90e-52
37LIPA, LGMN, CTSB, PSAP, CTSD, GPNMB, SLC40A1, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, ASAH1, CD5L, CTSS, CD14, GRN, CPVL, TYROBP, PLD3, MRC1, NPC2, ADAP2, FGL2, AIF1, CYBB, CTSC, CD4, FCGRT, CD84, MFSD1, IL18, CREG1, MSR1, MERTK, TPP1, LAIR1
 228
FAN_EMBRYONIC_CTX_MICROGLIA_3 1.89e-17 246.99 85.69 6.05e-16 1.27e-14
9LGMN, CTSB, CTSD, CD68, SLCO2B1, ASAH1, CTSC, CREG1, MERTK
 20
TRAVAGLINI_LUNG_TREM2_DENDRITIC_CELL 5.00e-52 145.49 64.43 1.68e-49 3.36e-49
43LIPA, APOE, LGMN, CTSB, PSAP, APOC1, CTSD, GPNMB, SLC40A1, CD68, SLCO2B1, CSF1R, IGSF6, MS4A4A, ASAH1, CTSS, CD14, GRN, C2, CPVL, TYROBP, PLD3, CD74, MRC1, NPL, NPC2, AIF1, FUCA1, CYBB, ACP5, CTSC, CD4, FCGRT, PLA2G7, CD84, GM2A, MFSD1, IL18, CREG1, MSR1, TPP1, LAIR1, SLAMF8
 572
FAN_EMBRYONIC_CTX_BIG_GROUPS_MICROGLIA 3.69e-45 95.96 49.97 8.26e-43 2.48e-42
36LIPA, APOE, LGMN, CTSB, PSAP, APOC1, CTSD, CD68, SLCO2B1, CSF1R, IGSF6, ASAH1, CTSS, CD14, GRN, C2, CPVL, TYROBP, PLD3, CD74, MRC1, NPL, NPC2, ADAP2, AIF1, CYBB, CTSC, CD4, FCGRT, CD84, GM2A, MFSD1, CREG1, MERTK, TPP1, LAIR1
 371
ZHONG_PFC_MAJOR_TYPES_MICROGLIA 1.80e-44 88.81 45.71 3.02e-42 1.21e-41
37LIPA, APOE, LGMN, CTSB, PSAP, APOC1, CTSD, CD68, SLCO2B1, CSF1R, IGSF6, ASAH1, CTSS, CD14, GRN, C2, CPVL, TYROBP, PLD3, CD74, MRC1, NPL, NPC2, ADAP2, AIF1, CYBB, CTSC, CD4, FCGRT, PLA2G7, CD84, GM2A, MFSD1, CREG1, MERTK, TPP1, LAIR1
 438
CUI_DEVELOPING_HEART_C8_MACROPHAGE 5.65e-38 76.36 41.38 6.31e-36 3.79e-35
30LGMN, CTSB, PSAP, CTSD, CD68, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, CTSS, CD14, GRN, CPVL, TYROBP, CD74, MRC1, NPC2, ADAP2, FGL2, AIF1, CYBB, CTSC, CD4, FCGRT, MFSD1, CREG1, MSR1, TPP1, LAIR1
 275
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MACROPHAGES 6.13e-22 81.04 39.11 2.74e-20 4.11e-19
15APOE, APOC1, SLC40A1, CD68, CSF1R, IGSF6, CTSS, CD14, GRN, TYROBP, CD74, NPC2, FGL2, AIF1, MSR1
 81
GAO_LARGE_INTESTINE_24W_C11_PANETH_LIKE_CELL 1.38e-37 69.39 37.52 1.32e-35 9.24e-35
31LIPA, LGMN, CD68, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, CD14, C2, CPVL, TYROBP, CD74, CD163L1, MRC1, NPL, ADAP2, FGL2, AIF1, CYBB, ACP5, CTSC, CD4, PLA2G7, CD84, GM2A, MFSD1, CREG1, MERTK, TPP1, SLAMF8
 325
MANNO_MIDBRAIN_NEUROTYPES_HMGL 6.15e-42 73.48 37.39 8.25e-40 4.12e-39
38LIPA, APOE, LGMN, CTSB, APOC1, CTSD, GPNMB, CD68, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, ASAH1, CD5L, CTSS, CD14, GRN, CPVL, TYROBP, CD74, MRC1, NPL, NPC2, ADAP2, FGL2, CYBB, CTSC, CD4, FCGRT, CD84, GM2A, MFSD1, IL18, CREG1, MERTK, TPP1, LAIR1
 577
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 3.75e-27 55.14 29.44 2.51e-25 2.51e-24
22LIPA, CTSB, PSAP, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, CTSS, GRN, CPVL, TYROBP, MRC1, NPC2, FGL2, AIF1, CYBB, CD84, MFSD1, IL18, MSR1, TPP1
 200
TRAVAGLINI_LUNG_MACROPHAGE_CELL 4.19e-27 54.83 29.28 2.56e-25 2.81e-24
22APOE, CTSB, PSAP, APOC1, CTSD, GPNMB, CD163, SLCO2B1, IGSF6, MS4A4A, ASAH1, CTSS, GRN, TYROBP, CD74, MRC1, NPC2, CYBB, ACP5, CTSC, FCGRT, MSR1
 201
HU_FETAL_RETINA_MICROGLIA 5.84e-32 48.92 26.66 4.90e-30 3.92e-29
29LIPA, LGMN, CTSB, PSAP, CTSD, SLCO2B1, CSF1R, IGSF6, CTSS, CD14, GRN, CPVL, TYROBP, CD74, NPL, NPC2, ADAP2, FGL2, AIF1, CYBB, CTSC, CD4, FCGRT, CD84, GM2A, MFSD1, CREG1, MERTK, LAIR1
 382
DESCARTES_FETAL_LIVER_MYELOID_CELLS 5.09e-25 48.13 25.58 2.85e-23 3.42e-22
21LIPA, LGMN, CTSB, CD68, CD163, CSF1R, IGSF6, MS4A4A, CD5L, CTSS, CPVL, TYROBP, CD163L1, ADAP2, FGL2, FUCA1, CYBB, PLA2G7, CREG1, MSR1, MERTK
 209
DESCARTES_FETAL_STOMACH_MYELOID_CELLS 5.49e-15 54.12 23.93 1.47e-13 3.68e-12
11IGSF6, CD14, CPVL, TYROBP, CD74, CD163L1, ADAP2, CYBB, CD4, CD84, MERTK
 76
DESCARTES_FETAL_ADRENAL_MYELOID_CELLS 3.55e-21 42.59 22.03 1.49e-19 2.38e-18
18LGMN, CD68, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, CD5L, CD14, CPVL, CD163L1, ADAP2, CYBB, CD4, PLA2G7, MSR1, MERTK, SLAMF8
 183
DESCARTES_FETAL_MUSCLE_MYELOID_CELLS 4.76e-17 41.82 20.29 1.45e-15 3.20e-14
14CD163, CSF1R, IGSF6, MS4A4A, CTSS, CD14, C2, CD74, CD163L1, ADAP2, AIF1, CYBB, PLA2G7, MERTK
 130
DESCARTES_FETAL_PLACENTA_MYELOID_CELLS 6.24e-18 40.86 20.21 2.09e-16 4.19e-15
15LGMN, CD163, IGSF6, CD5L, CD14, CPVL, TYROBP, CD74, CD163L1, ADAP2, FGL2, CYBB, ACP5, LAIR1, SLAMF8
 146
DESCARTES_FETAL_THYMUS_ANTIGEN_PRESENTING_CELLS 2.03e-18 37.68 19.01 7.58e-17 1.36e-15
16LGMN, CD68, IGSF6, CTSS, CD14, CPVL, TYROBP, CD74, CD163L1, ADAP2, FGL2, FUCA1, CYBB, CD84, IL18, SLAMF8
 172
DESCARTES_FETAL_CEREBELLUM_MICROGLIA 1.27e-28 33.43 18.17 9.47e-27 8.52e-26
31APOE, LGMN, CTSB, APOC1, GPNMB, CD68, CD163, CSF1R, IGSF6, MS4A4A, CD5L, CTSS, CD14, C2, CPVL, TYROBP, CD74, NPL, ADAP2, AIF1, CYBB, CTSC, CD4, PLA2G7, CD84, GM2A, MFSD1, IL18, CREG1, MERTK, LAIR1
 642
DESCARTES_FETAL_HEART_MYELOID_CELLS 2.88e-15 36.26 17.24 8.04e-14 1.93e-12
13LGMN, CD163, SLCO2B1, CSF1R, IGSF6, MS4A4A, CD14, TYROBP, CD74, CD163L1, CYBB, PLA2G7, SLAMF8
 134

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_COMPLEMENT 6.91e-08 14.37 6.05 3.45e-06 3.45e-06
9LIPA, LGMN, CTSB, APOC1, CTSD, CTSS, C2, CTSC, PLA2G7
 200
HALLMARK_ALLOGRAFT_REJECTION 1.24e-04 8.78 3.02 3.09e-03 6.18e-03
6IGSF6, CTSS, C2, CD74, CD4, IL18
 200
HALLMARK_COAGULATION 2.09e-03 8.11 2.09 3.49e-02 1.05e-01
4LGMN, CTSB, APOC1, C2
 138
HALLMARK_INFLAMMATORY_RESPONSE 7.71e-03 5.55 1.44 9.64e-02 3.85e-01
4CD14, CYBB, IL18, MSR1
 200
HALLMARK_MTORC1_SIGNALING 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3LGMN, FGL2, CTSC
 200
HALLMARK_P53_PATHWAY 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3CTSD, FUCA1, GM2A
 200
HALLMARK_KRAS_SIGNALING_UP 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3GPNMB, CTSS, FUCA1
 200
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 8.25e-01 1.00e+00
2CD14, IL18
 161
HALLMARK_INTERFERON_GAMMA_RESPONSE 1.85e-01 2.63 0.31 9.24e-01 1.00e+00
2CD74, FGL2
 200
HALLMARK_HEME_METABOLISM 1.85e-01 2.63 0.31 9.24e-01 1.00e+00
2CTSB, ACP5
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1LGMN
 74
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1CD14
 87
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1CTSC
 96
HALLMARK_INTERFERON_ALPHA_RESPONSE 3.20e-01 2.66 0.07 1.00e+00 1.00e+00
1CD74
 97
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 1.00e+00 1.00e+00
1MERTK
 100
HALLMARK_UV_RESPONSE_UP 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1CREG1
 158
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1FGL2
 199
HALLMARK_TNFA_SIGNALING_VIA_NFKB 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1IL18
 200
HALLMARK_ADIPOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1APOE
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1FUCA1
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_LYSOSOME 1.71e-17 45.36 21.95 3.17e-15 3.17e-15
14LIPA, LGMN, CTSB, PSAP, CTSD, CD68, ASAH1, CTSS, NPC2, FUCA1, ACP5, CTSC, GM2A, TPP1
 121
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 2.42e-05 16.72 5.05 2.25e-03 4.50e-03
5LGMN, CTSB, CTSS, CD74, CD4
 88
KEGG_HEMATOPOIETIC_CELL_LINEAGE 4.89e-03 9.50 1.85 3.03e-01 9.10e-01
3CSF1R, CD14, CD4
 87
KEGG_OTHER_GLYCAN_DEGRADATION 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1FUCA1
 16
KEGG_RIBOFLAVIN_METABOLISM 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1ACP5
 16
KEGG_STEROID_BIOSYNTHESIS 6.56e-02 15.93 0.37 1.00e+00 1.00e+00
1LIPA
 17
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 2.77e-01 1.98 0.23 1.00e+00 1.00e+00
2CSF1R, IL18
 265
KEGG_ETHER_LIPID_METABOLISM 1.23e-01 7.97 0.19 1.00e+00 1.00e+00
1PLA2G7
 33
KEGG_PRIMARY_IMMUNODEFICIENCY 1.30e-01 7.50 0.18 1.00e+00 1.00e+00
1CD4
 35
KEGG_SPHINGOLIPID_METABOLISM 1.44e-01 6.71 0.16 1.00e+00 1.00e+00
1ASAH1
 39
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1NPL
 44
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1IL18
 55
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1CD14
 56
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1IL18
 62
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 2.40e-01 3.75 0.09 1.00e+00 1.00e+00
1C2
 69
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 3.33e-01 2.53 0.06 1.00e+00 1.00e+00
1CD14
 102
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 3.49e-01 2.38 0.06 1.00e+00 1.00e+00
1CD4
 108
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 3.69e-01 2.22 0.05 1.00e+00 1.00e+00
1CYBB
 116
KEGG_CELL_ADHESION_MOLECULES_CAMS 4.10e-01 1.93 0.05 1.00e+00 1.00e+00
1CD4
 133
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 4.20e-01 1.88 0.05 1.00e+00 1.00e+00
1TYROBP
 137

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr8p22 1.37e-02 12.10 1.38 1.00e+00 1.00e+00
2ASAH1, MSR1
 45
chr1q23 5.30e-02 3.73 0.74 1.00e+00 1.00e+00
3CD5L, CD84, SLAMF8
 217
chr5q33 6.89e-02 4.87 0.57 1.00e+00 1.00e+00
2CD74, GM2A
 109
chr19q13 3.15e-01 1.47 0.51 1.00e+00 1.00e+00
6APOE, APOC1, TYROBP, PLD3, FCGRT, LAIR1
 1165
chr12p13 1.39e-01 2.42 0.48 1.00e+00 1.00e+00
3CD163, CD163L1, CD4
 333
chr6p21 7.00e-01 1.12 0.13 1.00e+00 1.00e+00
2C2, AIF1
 467
chr2q13 2.09e-01 4.40 0.11 1.00e+00 1.00e+00
1MERTK
 59
chrXp21 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1CYBB
 82
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1GPNMB
 96
chr2q32 3.49e-01 2.38 0.06 1.00e+00 1.00e+00
1SLC40A1
 108
chr1q24 3.87e-01 2.09 0.05 1.00e+00 1.00e+00
1CREG1
 123
chr10p12 4.15e-01 1.90 0.05 1.00e+00 1.00e+00
1MRC1
 135
chr11q14 4.29e-01 1.82 0.04 1.00e+00 1.00e+00
1CTSC
 141
chr3q25 4.53e-01 1.69 0.04 1.00e+00 1.00e+00
1MFSD1
 152
chr2q14 4.57e-01 1.67 0.04 1.00e+00 1.00e+00
1TMEM37
 154
chr1q25 4.70e-01 1.60 0.04 1.00e+00 1.00e+00
1NPL
 160
chr17q11 4.72e-01 1.59 0.04 1.00e+00 1.00e+00
1ADAP2
 161
chr7p14 4.76e-01 1.57 0.04 1.00e+00 1.00e+00
1CPVL
 163
chr16p12 4.78e-01 1.56 0.04 1.00e+00 1.00e+00
1IGSF6
 164
chr10q23 5.29e-01 1.35 0.03 1.00e+00 1.00e+00
1LIPA
 190

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
TCANNTGAY_SREBP1_01 4.34e-04 5.06 2.04 4.92e-01 4.92e-01
8PSAP, CTSD, GPNMB, CD5L, CTSS, GRN, C2, TPP1
 479
ZNF354B_TARGET_GENES 8.25e-03 5.43 1.41 1.00e+00 1.00e+00
4CTSD, GRN, MFSD1, TPP1
 204
GGGNNTTTCC_NFKB_Q6_01 1.57e-02 6.09 1.20 1.00e+00 1.00e+00
3CSF1R, CD74, SLAMF8
 134
TFEB_TARGET_GENES 1.42e-02 2.56 1.18 1.00e+00 1.00e+00
11CTSB, CTSD, CD68, CD5L, GRN, C2, PLD3, ACP5, FCGRT, MFSD1, TPP1
 1387
PEA3_Q6 1.91e-02 4.20 1.09 1.00e+00 1.00e+00
4CTSS, FUCA1, CD84, IL18
 263
ZNF768_TARGET_GENES 2.60e-02 2.34 1.04 1.00e+00 1.00e+00
10APOE, SLCO2B1, ASAH1, CTSS, GRN, CPVL, TYROBP, CTSC, TMEM37, SLAMF8
 1346
CBFA2T2_TARGET_GENES 4.41e-02 2.10 0.97 1.00e+00 1.00e+00
11CTSB, APOC1, CTSD, GPNMB, SLC40A1, GRN, PLD3, NPL, ACP5, MFSD1, TPP1
 1694
ZNF410_TARGET_GENES 2.97e-02 2.76 0.96 1.00e+00 1.00e+00
6CTSD, SLC40A1, GRN, PLD3, MFSD1, TPP1
 623
ZNF507_TARGET_GENES 3.58e-02 2.64 0.91 1.00e+00 1.00e+00
6CTSD, GPNMB, GRN, PLD3, MFSD1, TPP1
 653
BACH2_TARGET_GENES 9.82e-02 1.78 0.82 1.00e+00 1.00e+00
11PSAP, GPNMB, CD68, SLCO2B1, CSF1R, ASAH1, PLD3, FGL2, TMEM37, CD84, MSR1
 1998
TBX3_TARGET_GENES 4.66e-02 3.13 0.81 1.00e+00 1.00e+00
4CD68, C2, PLD3, TPP1
 351
ADNP_TARGET_GENES 5.32e-02 5.66 0.66 1.00e+00 1.00e+00
2CTSS, FCGRT
 94
LCORL_TARGET_GENES 9.69e-02 2.41 0.63 1.00e+00 1.00e+00
4CTSB, SLCO2B1, C2, PLD3
 455
MAFG_TARGET_GENES 2.94e-01 1.46 0.62 1.00e+00 1.00e+00
9PSAP, APOC1, GPNMB, SLCO2B1, PLD3, CD163L1, NPL, FCGRT, TMEM37
 1893
CREL_01 7.87e-02 3.14 0.62 1.00e+00 1.00e+00
3CSF1R, CD74, SLAMF8
 257
TERF1_TARGET_GENES 1.07e-01 2.73 0.54 1.00e+00 1.00e+00
3CTSS, CD74, TPP1
 295
IRF9_TARGET_GENES 5.23e-01 1.29 0.52 1.00e+00 1.00e+00
8CTSB, SLCO2B1, CSF1R, NPL, NPC2, FUCA1, MFSD1, SLAMF8
 1857
ZBTB24_TARGET_GENES 5.01e-01 1.28 0.49 1.00e+00 1.00e+00
7CTSB, GPNMB, ASAH1, CPVL, ADAP2, GM2A, CREG1
 1595
ZNF549_TARGET_GENES 2.87e-01 1.84 0.48 1.00e+00 1.00e+00
4LIPA, GRN, PLD3, ADAP2
 594
ZNF213_TARGET_GENES 2.88e-01 1.84 0.48 1.00e+00 1.00e+00
4LIPA, GRN, ADAP2, FCGRT
 595

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_REGULATION_OF_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION 9.58e-06 99.16 16.45 3.98e-03 7.17e-02
3CD68, CD74, FGL2
 11
GOBP_NEGATIVE_REGULATION_OF_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE 1.54e-04 172.68 14.09 3.04e-02 1.00e+00
2GRN, SLAMF8
 5
GOBP_DENDRITIC_CELL_ANTIGEN_PROCESSING_AND_PRESENTATION 2.61e-05 66.24 11.62 8.87e-03 1.95e-01
3CD68, CD74, FGL2
 15
GOBP_REGULATION_OF_MONOCYTE_CHEMOTAXIS 3.63e-06 47.11 11.40 1.81e-03 2.71e-02
4LGMN, AIF1, PLA2G7, SLAMF8
 27
GOBP_RESPIRATORY_BURST_INVOLVED_IN_INFLAMMATORY_RESPONSE 3.22e-04 103.49 9.64 4.61e-02 1.00e+00
2GRN, SLAMF8
 7
GOBP_GLYCOLIPID_TRANSPORT 3.22e-04 103.49 9.64 4.61e-02 1.00e+00
2PSAP, NPC2
 7
GOBP_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION 6.44e-05 46.77 8.51 1.51e-02 4.82e-01
3CD68, CD74, FGL2
 20
GOBP_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS 6.44e-05 46.77 8.51 1.51e-02 4.82e-01
3LGMN, AIF1, PLA2G7
 20
GOBP_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE 4.28e-04 86.37 8.33 5.62e-02 1.00e+00
2APOE, APOC1
 8
GOBP_MYELOID_LEUKOCYTE_ACTIVATION 5.74e-15 14.20 7.65 4.30e-11 4.30e-11
21CTSB, PSAP, CTSD, CD68, ASAH1, CTSS, CD14, GRN, TYROBP, CD74, NPC2, FGL2, AIF1, FUCA1, CYBB, CTSC, CD84, GM2A, IL18, CREG1, LAIR1
 659
GOBP_NEGATIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION 5.49e-04 74.10 7.33 6.63e-02 1.00e+00
2CD68, FGL2
 9
GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_ESTERIFICATION 5.49e-04 74.10 7.33 6.63e-02 1.00e+00
2APOE, APOC1
 9
GOBP_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY 6.46e-13 13.23 6.94 1.21e-09 4.83e-09
18CTSB, PSAP, CTSD, CD68, ASAH1, CTSS, CD14, GRN, TYROBP, NPC2, FGL2, FUCA1, CYBB, CTSC, CD84, GM2A, CREG1, LAIR1
 550
GOBP_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE 5.50e-06 23.11 6.92 2.57e-03 4.12e-02
5LIPA, APOE, APOC1, NPC2, MSR1
 65
GOBP_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE 6.85e-04 64.86 6.55 7.88e-02 1.00e+00
2APOE, APOC1
 10
GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 4.01e-13 11.88 6.36 9.99e-10 3.00e-09
20CTSB, PSAP, CTSD, CD68, ASAH1, CTSS, CD14, GRN, TYROBP, CD74, NPC2, FGL2, FUCA1, CYBB, CTSC, CD84, GM2A, IL18, CREG1, LAIR1
 722
GOBP_MICROGLIAL_CELL_ACTIVATION 3.46e-05 25.26 6.32 1.03e-02 2.58e-01
4GRN, TYROBP, AIF1, CTSC
 47
GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS 2.67e-06 17.93 6.10 1.43e-03 2.00e-02
6LIPA, APOE, APOC1, NPC2, PLA2G7, MSR1
 101
GOBP_POSITIVE_REGULATION_OF_MONOCYTE_DIFFERENTIATION 8.35e-04 57.69 5.91 8.42e-02 1.00e+00
2CD74, CD4
 11
GOBP_POSITIVE_REGULATION_BY_SYMBIONT_OF_ENTRY_INTO_HOST 8.35e-04 57.69 5.91 8.42e-02 1.00e+00
2CD74, CD4
 11

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_DN 1.99e-25 50.47 26.84 9.70e-22 9.70e-22
21LIPA, CTSB, PSAP, APOC1, CD163, CSF1R, IGSF6, MS4A4A, CD14, GRN, C2, TYROBP, MRC1, NPC2, FGL2, FUCA1, CTSC, FCGRT, CREG1, MERTK, SLAMF8
 200
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_DN 3.58e-22 42.78 22.37 7.05e-19 1.75e-18
19LIPA, CTSB, PSAP, CD68, CD163, ASAH1, CTSS, CD14, TYROBP, NPL, FGL2, CYBB, ACP5, CTSC, FCGRT, PLA2G7, GM2A, IL18, CREG1
 198
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 4.34e-22 42.31 22.14 7.05e-19 2.12e-18
19CTSB, PSAP, CTSD, CSF1R, IGSF6, ASAH1, CD14, GRN, TYROBP, CD74, NPL, ADAP2, FGL2, AIF1, CYBB, FCGRT, GM2A, CREG1, TPP1
 200
GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN 6.65e-19 35.18 18.04 5.40e-16 3.24e-15
17CTSB, PSAP, CSF1R, IGSF6, ASAH1, CTSS, CD14, GRN, CPVL, TYROBP, NPL, NPC2, ADAP2, FGL2, CYBB, MFSD1, CREG1
 200
GSE24634_TEFF_VS_TCONV_DAY3_IN_CULTURE_DN 6.65e-19 35.18 18.04 5.40e-16 3.24e-15
17LIPA, CD68, CD163, MS4A4A, CD14, C2, CPVL, NPL, ADAP2, FGL2, CYBB, FCGRT, CD84, MFSD1, MERTK, LAIR1, SLAMF8
 200
GSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_IL6_TREATED_DN 6.65e-19 35.18 18.04 5.40e-16 3.24e-15
17CTSB, PSAP, GPNMB, ASAH1, CTSS, GRN, CPVL, PLD3, NPL, FGL2, FUCA1, ACP5, CD4, CREG1, MSR1, TPP1, LAIR1
 200
GSE29618_MONOCYTE_VS_MDC_DAY7_FLU_VACCINE_UP 2.27e-17 31.95 16.17 1.58e-14 1.10e-13
16CTSB, PSAP, CTSD, CD68, CD163, ASAH1, CTSS, CD14, NPL, NPC2, AIF1, FUCA1, CYBB, PLA2G7, CREG1, LAIR1
 200
GSE34156_UNTREATED_VS_6H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_UP 5.62e-16 29.42 14.66 3.04e-13 2.74e-12
15PSAP, CD163, CSF1R, IGSF6, ASAH1, CD14, GRN, NPC2, CYBB, FCGRT, GM2A, MFSD1, CREG1, MSR1, TPP1
 197
GSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_UP 5.62e-16 29.42 14.66 3.04e-13 2.74e-12
15PSAP, CTSD, CD163, CSF1R, IGSF6, ASAH1, CD14, GRN, TYROBP, CYBB, FCGRT, GM2A, CREG1, MSR1, MERTK
 197
GSE22886_NAIVE_TCELL_VS_MONOCYTE_DN 7.03e-16 28.93 14.43 3.11e-13 3.43e-12
15CTSB, PSAP, IGSF6, ASAH1, CD14, GRN, CPVL, NPL, NPC2, ADAP2, FGL2, CYBB, MFSD1, CREG1, TPP1
 200
GSE29618_MONOCYTE_VS_MDC_UP 7.03e-16 28.93 14.43 3.11e-13 3.43e-12
15CTSB, PSAP, CTSD, CD68, CD163, ASAH1, CTSS, CD14, TYROBP, NPL, NPC2, AIF1, CYBB, PLA2G7, CREG1
 200
GSE24634_TREG_VS_TCONV_POST_DAY5_IL4_CONVERSION_DN 1.72e-14 26.41 12.93 6.88e-12 8.39e-11
14LIPA, CTSB, CD68, CSF1R, IGSF6, CTSS, GRN, TYROBP, NPC2, CYBB, ACP5, FCGRT, CD84, CREG1
 198
GSE6259_33D1_POS_DC_VS_CD4_TCELL_DN 9.87e-14 26.92 12.88 3.20e-11 4.81e-10
13APOE, LGMN, GPNMB, SLCO2B1, TYROBP, PLD3, NPL, ACP5, CD4, CD84, MERTK, TPP1, LAIR1
 176
GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_DN 1.98e-14 26.13 12.79 6.88e-12 9.64e-11
14CTSB, PSAP, IGSF6, ASAH1, CTSS, CD14, GRN, NPC2, ADAP2, FGL2, CYBB, MFSD1, CREG1, TPP1
 200
GSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY5_UP 1.98e-14 26.13 12.79 6.88e-12 9.64e-11
14LGMN, CD68, SLCO2B1, CSF1R, IGSF6, MS4A4A, CPVL, MRC1, NPL, NPC2, FUCA1, PLA2G7, CREG1, LAIR1
 200
GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_DN 5.03e-13 23.47 11.26 1.44e-10 2.45e-09
13CTSB, PSAP, CTSD, CD163, CSF1R, IGSF6, TYROBP, NPL, ADAP2, FGL2, AIF1, FCGRT, CREG1
 200
GSE19401_PAM2CSK4_VS_RETINOIC_ACID_AND_PAM2CSK4_STIM_FOLLICULAR_DC_DN 5.03e-13 23.47 11.26 1.44e-10 2.45e-09
13LIPA, APOE, APOC1, CTSD, GPNMB, CD163, SLCO2B1, ASAH1, GRN, MRC1, ACP5, GM2A, LAIR1
 200
GSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_DN 1.15e-11 20.99 9.83 2.67e-09 5.60e-08
12LIPA, CTSB, PSAP, CTSS, TYROBP, NPC2, AIF1, ACP5, FCGRT, PLA2G7, CD84, GM2A
 200
GSE29618_BCELL_VS_MONOCYTE_DAY7_FLU_VACCINE_DN 1.15e-11 20.99 9.83 2.67e-09 5.60e-08
12PSAP, CTSD, CD68, CD163, CSF1R, CD14, GRN, TYROBP, NPL, CD4, FCGRT, CREG1
 200
GSE21670_UNTREATED_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_UP 1.15e-11 20.99 9.83 2.67e-09 5.60e-08
12PSAP, CSF1R, CTSS, PLD3, FGL2, CYBB, ACP5, CD4, GM2A, CREG1, TPP1, LAIR1
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
CREG1 45 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Regulates transcription in tethering assays (PMID: 9710587). Unlikely to be a TF, based on the lack of a canonical DBD
SGK1 53 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ITGB2 56 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MAFB 70 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence
NR1H3 77 Yes Inferred motif Obligate heteromer In vivo/Misc source None Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA
LGALS9 81 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SYK 91 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-factor
STAT1 95 Yes Known motif Monomer or homomultimer In vivo/Misc source None Structure PDB:1BF5 is Tyrosine phosphorylated
SPI1 106 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CEBPA 125 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
TLR4 129 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NFAM1 140 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development (PMID: 15143214)
HCK 144 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits TP73-mediated transcription activation (PMID: 17535448)
PYCARD 174 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
CREBL2 183 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
TRIM14 208 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
CIITA 217 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Chromatin modifier
NR4A2 235 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CMKLR1 246 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a G protein-coupled receptor for the chemoattractant adipokine chemerin
NCOA4 269 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
WK067-G18 Macrophage:monocyte-derived:M-CSF 0.20 1361.46
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.5, DC:monocyte-derived:anti-DC-SIGN_2h: 0.5, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.49, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.49, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg: 0.49, Monocyte:leukotriene_D4: 0.49, DC:monocyte-derived:antiCD40/VAF347: 0.48, DC:monocyte-derived: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48
WK071-B16 Monocyte:CD16+ 0.15 1287.99
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.48, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.47, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.47, Monocyte:leukotriene_D4: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, Monocyte:CD16+: 0.46, Monocyte: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Monocyte:anti-FcgRIIB: 0.46
WK069-F4 DC:monocyte-derived:anti-DC-SIGN_2h 0.16 907.06
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.43, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.43, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, DC:monocyte-derived: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42
KK002-L23 Macrophage:monocyte-derived:M-CSF 0.21 886.03
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.57, Monocyte:leukotriene_D4: 0.56, Macrophage:monocyte-derived:M-CSF/IFNg: 0.55, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.55, Monocyte: 0.55, DC:monocyte-derived:Galectin-1: 0.55, DC:monocyte-derived:LPS: 0.55, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.55, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.55, Macrophage:monocyte-derived: 0.55
WK024-A19 Macrophage:monocyte-derived:M-CSF/IFNg 0.21 827.85
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.5, Macrophage:monocyte-derived:IL-4/cntrl: 0.5, Macrophage:monocyte-derived:IL-4/TGFb: 0.5, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.5, Macrophage:monocyte-derived:M-CSF: 0.5, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.49, Macrophage:monocyte-derived:IFNa: 0.49, DC:monocyte-derived:AEC-conditioned: 0.48, DC:monocyte-derived: 0.48, Macrophage:monocyte-derived: 0.48
WK014-C17 Macrophage:monocyte-derived:M-CSF 0.21 741.96
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.52, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.52, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.52, Macrophage:monocyte-derived:IL-4/cntrl: 0.5, Macrophage:monocyte-derived:IL-4/TGFb: 0.5, Macrophage:monocyte-derived: 0.5, DC:monocyte-derived:anti-DC-SIGN_2h: 0.5, DC:monocyte-derived: 0.49, Monocyte:leukotriene_D4: 0.49, DC:monocyte-derived:antiCD40/VAF347: 0.49
WK074-O1 DC:monocyte-derived:anti-DC-SIGN_2h 0.16 606.33
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:M-CSF: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, DC:monocyte-derived: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, DC:monocyte-derived:Galectin-1: 0.41
WK073-P9 Macrophage:monocyte-derived:M-CSF 0.16 598.09
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.43, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Monocyte:anti-FcgRIIB: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Monocyte:S._typhimurium_flagellin: 0.42
WK074-M5 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.17 556.86
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.4, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, Monocyte:leukotriene_D4: 0.38, Monocyte: 0.38, Monocyte:anti-FcgRIIB: 0.37, Macrophage:monocyte-derived:IL-4/TGFb: 0.37, DC:monocyte-derived:immature: 0.37
KK053-N11 Macrophage:monocyte-derived:M-CSF 0.18 535.29
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.51, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.51, Macrophage:monocyte-derived:M-CSF: 0.51, DC:monocyte-derived: 0.5, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.5, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.5, DC:monocyte-derived:LPS: 0.5, DC:monocyte-derived:Galectin-1: 0.5, Macrophage:monocyte-derived:IL-4/TGFb: 0.5, DC:monocyte-derived:anti-DC-SIGN_2h: 0.5
WK073-L16 DC:monocyte-derived:antiCD40/VAF347 0.17 516.81
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, DC:monocyte-derived:antiCD40/VAF347: 0.46, Monocyte:S._typhimurium_flagellin: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Macrophage:monocyte-derived:S._aureus: 0.45, Monocyte:anti-FcgRIIB: 0.44, DC:monocyte-derived:LPS: 0.44, DC:monocyte-derived:Galectin-1: 0.44
WK065-E2 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.13 466.21
Raw ScoresMonocyte:leukotriene_D4: 0.51, Monocyte:anti-FcgRIIB: 0.49, Monocyte: 0.49, DC:monocyte-derived:anti-DC-SIGN_2h: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48, Macrophage:monocyte-derived:M-CSF: 0.48, Macrophage:monocyte-derived:IFNa: 0.48, Pre-B_cell_CD34-: 0.48, Monocyte:CD16+: 0.47
WK073-O22 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.20 462.23
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.51, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.5, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.49, DC:monocyte-derived:antiCD40/VAF347: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg: 0.49, Macrophage:monocyte-derived:S._aureus: 0.49, Macrophage:monocyte-derived:M-CSF: 0.49, DC:monocyte-derived:LPS: 0.49, DC:monocyte-derived:Galectin-1: 0.49, Macrophage:Alveolar:B._anthacis_spores: 0.49
WK024-P3 Macrophage:monocyte-derived:M-CSF/IFNg 0.17 459.32
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:M-CSF: 0.38, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.38, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, Monocyte:leukotriene_D4: 0.37, DC:monocyte-derived: 0.37, DC:monocyte-derived:AEC-conditioned: 0.37, Monocyte:anti-FcgRIIB: 0.36, Monocyte: 0.36
WK024-K7 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.15 427.40
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.37, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37, DC:monocyte-derived:anti-DC-SIGN_2h: 0.37, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, Monocyte:leukotriene_D4: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, DC:monocyte-derived: 0.35, DC:monocyte-derived:LPS: 0.35, Monocyte:anti-FcgRIIB: 0.35
WK024-O21 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.17 422.41
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.37, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37, DC:monocyte-derived:anti-DC-SIGN_2h: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, DC:monocyte-derived: 0.36, Macrophage:monocyte-derived:IL-4/TGFb: 0.35, Macrophage:monocyte-derived:IL-4/cntrl: 0.35, DC:monocyte-derived:AEC-conditioned: 0.35, Monocyte:leukotriene_D4: 0.35
WK024-I21 Macrophage:monocyte-derived:M-CSF/IFNg 0.17 410.13
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.4, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.39, Macrophage:monocyte-derived:IL-4/cntrl: 0.39, Macrophage:monocyte-derived:IL-4/TGFb: 0.38, DC:monocyte-derived:AEC-conditioned: 0.38, DC:monocyte-derived:immature: 0.38, Monocyte:leukotriene_D4: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38
WK074-E23 Macrophage:monocyte-derived:S._aureus 0.15 406.78
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.46, DC:monocyte-derived:antiCD40/VAF347: 0.45, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.45, Macrophage:monocyte-derived:S._aureus: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, DC:monocyte-derived:Galectin-1: 0.44, DC:monocyte-derived:LPS: 0.44, Macrophage:Alveolar:B._anthacis_spores: 0.43, DC:monocyte-derived: 0.43, DC:monocyte-derived:Schuler_treatment: 0.43
TM96-D4 DC:monocyte-derived:antiCD40/VAF347 0.17 404.86
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.56, Macrophage:monocyte-derived:S._aureus: 0.55, Macrophage:monocyte-derived: 0.55, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.55, DC:monocyte-derived:Galectin-1: 0.55, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.54, DC:monocyte-derived: 0.54, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.54, DC:monocyte-derived:LPS: 0.54, DC:monocyte-derived:CD40L: 0.54
WK024-P21 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.16 391.19
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.31, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.31, Macrophage:monocyte-derived:M-CSF: 0.3, DC:monocyte-derived:immature: 0.29, Macrophage:monocyte-derived: 0.29, Macrophage:monocyte-derived:IL-4/cntrl: 0.29, DC:monocyte-derived:anti-DC-SIGN_2h: 0.29, Macrophage:monocyte-derived:M-CSF/IFNg: 0.28, DC:monocyte-derived: 0.28, Macrophage:monocyte-derived:IL-4/TGFb: 0.28
TM37-E5 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.18 376.30
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.45, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.45, DC:monocyte-derived:antiCD40/VAF347: 0.45, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Monocyte:leukotriene_D4: 0.44, Monocyte:anti-FcgRIIB: 0.44, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.44, DC:monocyte-derived: 0.44
WK073-N11 DC:monocyte-derived:A._fumigatus_germ_tubes_6h 0.17 361.69
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.45, DC:monocyte-derived:anti-DC-SIGN_2h: 0.44, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.44, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.44, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.44, Monocyte:leukotriene_D4: 0.43, DC:monocyte-derived: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.43, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43
WK024-H21 Monocyte:CD16+ 0.17 356.92
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Monocyte:CD16-: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Monocyte:CD14+: 0.42, Monocyte:CD16+: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Monocyte: 0.41, Monocyte:leukotriene_D4: 0.41, Monocyte:anti-FcgRIIB: 0.41
WK024-H8 Monocyte:CD16+ 0.14 335.57
Raw ScoresMonocyte:leukotriene_D4: 0.48, Monocyte:CD16+: 0.47, Monocyte: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:anti-FcgRIIB: 0.47, Monocyte:CD14+: 0.46, HSC_-G-CSF: 0.46, Monocyte:CD16-: 0.46, Pre-B_cell_CD34-: 0.46, Macrophage:monocyte-derived:M-CSF: 0.45
WK024-M22 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.16 318.55
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.34, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.34, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.34, DC:monocyte-derived:anti-DC-SIGN_2h: 0.33, Monocyte:leukotriene_D4: 0.33, Macrophage:monocyte-derived:M-CSF/IFNg: 0.32, DC:monocyte-derived: 0.32, DC:monocyte-derived:AEC-conditioned: 0.32, Monocyte: 0.32, Monocyte:anti-FcgRIIB: 0.32
WK024-N23 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.14 312.88
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.34, Macrophage:monocyte-derived:M-CSF/IFNg: 0.33, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.33, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.33, DC:monocyte-derived:anti-DC-SIGN_2h: 0.32, Monocyte:leukotriene_D4: 0.32, DC:monocyte-derived: 0.32, DC:monocyte-derived:immature: 0.32, Macrophage:monocyte-derived:IL-4/cntrl: 0.32, DC:monocyte-derived:AEC-conditioned: 0.32
WK012-C9 Macrophage:monocyte-derived:M-CSF/Pam3Cys 0.19 310.37
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.46, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, Monocyte:S._typhimurium_flagellin: 0.45, DC:monocyte-derived:anti-DC-SIGN_2h: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, Monocyte:anti-FcgRIIB: 0.43, DC:monocyte-derived:Galectin-1: 0.43
WK014-F23 DC:monocyte-derived:antiCD40/VAF347 0.19 308.88
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.47, DC:monocyte-derived:antiCD40/VAF347: 0.47, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46, Macrophage:monocyte-derived:S._aureus: 0.46, DC:monocyte-derived: 0.46, Monocyte:S._typhimurium_flagellin: 0.46, Macrophage:monocyte-derived:M-CSF: 0.46, DC:monocyte-derived:Galectin-1: 0.46
WK012-O10 Macrophage:monocyte-derived:M-CSF 0.17 299.10
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Macrophage:Alveolar:B._anthacis_spores: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.41, DC:monocyte-derived: 0.41
KK055-N5 Macrophage:monocyte-derived:M-CSF 0.15 296.56
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.47, Monocyte:leukotriene_D4: 0.47, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46, Monocyte:anti-FcgRIIB: 0.46, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.46, Monocyte: 0.46, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.46, DC:monocyte-derived:LPS: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, DC:monocyte-derived:Galectin-1: 0.46
WK024-M16 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.14 286.94
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.32, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.32, DC:monocyte-derived:anti-DC-SIGN_2h: 0.31, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.31, Macrophage:monocyte-derived:M-CSF/IFNg: 0.31, Monocyte:leukotriene_D4: 0.31, DC:monocyte-derived:AEC-conditioned: 0.3, DC:monocyte-derived: 0.3, Monocyte: 0.3, Monocyte:anti-FcgRIIB: 0.3
WK073-L8 DC:monocyte-derived:antiCD40/VAF347 0.18 279.04
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.45, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.45, Monocyte:S._typhimurium_flagellin: 0.45, Macrophage:monocyte-derived:S._aureus: 0.44, DC:monocyte-derived:LPS: 0.44, DC:monocyte-derived:Schuler_treatment: 0.43, DC:monocyte-derived:Galectin-1: 0.43, DC:monocyte-derived:Poly(IC): 0.43
WK024-B21 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.15 278.80
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.34, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.34, Macrophage:monocyte-derived:M-CSF: 0.34, DC:monocyte-derived:anti-DC-SIGN_2h: 0.33, DC:monocyte-derived: 0.32, Macrophage:monocyte-derived:M-CSF/IFNg: 0.32, DC:monocyte-derived:immature: 0.32, DC:monocyte-derived:AEC-conditioned: 0.32, Monocyte:leukotriene_D4: 0.32, Macrophage:monocyte-derived:IL-4/cntrl: 0.32
WK024-H12 Macrophage:monocyte-derived:M-CSF/IFNg 0.16 277.36
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.4, Macrophage:monocyte-derived:M-CSF: 0.39, Monocyte:leukotriene_D4: 0.39, Monocyte:CD16-: 0.38, Monocyte: 0.38, Monocyte:anti-FcgRIIB: 0.38, Monocyte:CD16+: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, DC:monocyte-derived:AEC-conditioned: 0.38, Monocyte:CD14+: 0.38
WK012-F20 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.18 276.75
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.43, Monocyte:leukotriene_D4: 0.41, Macrophage:monocyte-derived:IL-4/TGFb: 0.41, Macrophage:monocyte-derived:IL-4/cntrl: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.41, DC:monocyte-derived: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.4
TM96-C13 Macrophage:monocyte-derived 0.12 274.56
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.45, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.45, DC:monocyte-derived: 0.45, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Macrophage:monocyte-derived: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.44
WK032-B13 DC:monocyte-derived:antiCD40/VAF347 0.18 269.97
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48, DC:monocyte-derived:antiCD40/VAF347: 0.48, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.48, Macrophage:monocyte-derived:S._aureus: 0.48, Macrophage:Alveolar:B._anthacis_spores: 0.47, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.47, DC:monocyte-derived:Galectin-1: 0.47, DC:monocyte-derived:LPS: 0.47, Macrophage:Alveolar: 0.47, DC:monocyte-derived:CD40L: 0.46
WMK004-J2 Macrophage:monocyte-derived:M-CSF/IFNg 0.16 269.36
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Monocyte:leukotriene_D4: 0.41, Macrophage:monocyte-derived:M-CSF: 0.41, DC:monocyte-derived:antiCD40/VAF347: 0.41, DC:monocyte-derived:LPS: 0.4, DC:monocyte-derived:anti-DC-SIGN_2h: 0.4, Monocyte:anti-FcgRIIB: 0.4, DC:monocyte-derived:Galectin-1: 0.4, Monocyte: 0.4
WK024-M19 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.14 265.27
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.32, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.32, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.31, Macrophage:monocyte-derived:M-CSF/IFNg: 0.31, DC:monocyte-derived:anti-DC-SIGN_2h: 0.31, Monocyte:leukotriene_D4: 0.3, DC:monocyte-derived:AEC-conditioned: 0.3, DC:monocyte-derived: 0.3, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.3, Monocyte: 0.3
WK027-C6 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.12 259.52
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.37, Macrophage:monocyte-derived:M-CSF: 0.36, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.35, Monocyte:leukotriene_D4: 0.35, DC:monocyte-derived:AEC-conditioned: 0.35, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.35, Monocyte: 0.35, Monocyte:anti-FcgRIIB: 0.35, Macrophage:monocyte-derived: 0.35, Macrophage:monocyte-derived:IFNa: 0.34
WK024-M15 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.14 250.23
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.32, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.31, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.31, Macrophage:monocyte-derived:M-CSF/IFNg: 0.3, DC:monocyte-derived:AEC-conditioned: 0.3, Monocyte:leukotriene_D4: 0.3, Macrophage:monocyte-derived:IL-4/TGFb: 0.29, Macrophage:monocyte-derived:IL-4/cntrl: 0.29, DC:monocyte-derived: 0.29, DC:monocyte-derived:anti-DC-SIGN_2h: 0.29
WK024-L20 Monocyte:CD16- 0.16 250.22
Raw ScoresMonocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Macrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Monocyte:leukotriene_D4: 0.42, Monocyte: 0.42, Monocyte:CD16+: 0.42, Monocyte:anti-FcgRIIB: 0.41, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.41, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.41
WMK006-D1 Macrophage:monocyte-derived:M-CSF 0.15 246.18
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.37, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.37, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.37, DC:monocyte-derived:antiCD40/VAF347: 0.37, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.37, DC:monocyte-derived:LPS: 0.37, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.37, Macrophage:monocyte-derived:IFNa: 0.37
WK024-B15 Monocyte:CD16+ 0.16 245.46
Raw ScoresMonocyte:CD16-: 0.46, Monocyte:CD16+: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Monocyte:leukotriene_D4: 0.45, Monocyte: 0.45, Monocyte:CD14+: 0.45, Monocyte:anti-FcgRIIB: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43
KK057-F17 T_cell:CD4+ 0.08 245.07
Raw ScoresMonocyte:leukotriene_D4: 0.51, DC:monocyte-derived:anti-DC-SIGN_2h: 0.51, Monocyte: 0.51, Monocyte:CD16+: 0.51, Pre-B_cell_CD34-: 0.51, Monocyte:CD16-: 0.51, NK_cell: 0.51, Monocyte:CD14+: 0.5, B_cell:Memory: 0.5, Macrophage:monocyte-derived:M-CSF/IFNg: 0.5
WK074-C18 DC:monocyte-derived:antiCD40/VAF347 0.19 241.73
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.46, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:S._typhimurium_flagellin: 0.45, Macrophage:monocyte-derived:S._aureus: 0.44, DC:monocyte-derived:Galectin-1: 0.44, DC:monocyte-derived:LPS: 0.44, DC:monocyte-derived:Schuler_treatment: 0.44, DC:monocyte-derived:CD40L: 0.44
WK016-N23 Tissue_stem_cells:BM_MSC:BMP2 0.07 241.16
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.34, DC:monocyte-derived:AEC-conditioned: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, iPS_cells:adipose_stem_cells: 0.34, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.33, DC:monocyte-derived:antiCD40/VAF347: 0.33, DC:monocyte-derived:mature: 0.33, Smooth_muscle_cells:vascular:IL-17: 0.33, DC:monocyte-derived:LPS: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33
WK012-C10 DC:monocyte-derived:antiCD40/VAF347 0.19 239.62
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.43, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Monocyte:S._typhimurium_flagellin: 0.42, Macrophage:monocyte-derived:M-CSF: 0.41, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.41, DC:monocyte-derived:Galectin-1: 0.41, DC:monocyte-derived:LPS: 0.41
KK002-H6 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.13 235.95
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.4, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.4, DC:monocyte-derived:AEC-conditioned: 0.4, DC:monocyte-derived: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Macrophage:monocyte-derived: 0.4, Macrophage:monocyte-derived:IL-4/TGFb: 0.4
WK016-M1 DC:monocyte-derived:antiCD40/VAF347 0.16 230.88
Raw ScoresMacrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, DC:monocyte-derived:antiCD40/VAF347: 0.38, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.37, Monocyte:S._typhimurium_flagellin: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, DC:monocyte-derived:LPS: 0.37, Macrophage:Alveolar:B._anthacis_spores: 0.37, DC:monocyte-derived:Galectin-1: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.74e-03
Mean rank of genes in gene set: 164
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD163 0.0074670 11 GTEx DepMap Descartes 4.24 245.25
AIF1 0.0048874 32 GTEx DepMap Descartes 3.18 726.55
RGS10 0.0009311 449 GTEx DepMap Descartes 1.24 390.57


Protein maturation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.56e-03
Mean rank of genes in gene set: 821.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RPN2 0.0008935 471 GTEx DepMap Descartes 1.58 174.99
OS9 0.0006076 718 GTEx DepMap Descartes 1.40 102.14
PDIA3 0.0003379 1275 GTEx DepMap Descartes 1.71 108.93


Stress response (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.02e-03
Mean rank of genes in gene set: 890.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FOS 0.0009879 407 GTEx DepMap Descartes 13.71 1782.22
JUN 0.0005878 749 GTEx DepMap Descartes 5.65 458.25
JUNB 0.0002707 1515 GTEx DepMap Descartes 9.74 1334.75




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8806.19
Median rank of genes in gene set: 9895
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
UCP2 0.0023577 123 GTEx DepMap Descartes 2.33 296.92
DAPK1 0.0022188 137 GTEx DepMap Descartes 1.02 42.17
ATP6V1B2 0.0014798 244 GTEx DepMap Descartes 4.53 169.10
MYO5A 0.0009333 447 GTEx DepMap Descartes 0.80 15.20
LYN 0.0009312 448 GTEx DepMap Descartes 2.28 92.58
ST3GAL6 0.0008896 473 GTEx DepMap Descartes 0.92 66.83
GLRX 0.0007968 525 GTEx DepMap Descartes 1.29 90.13
AP1S2 0.0007368 580 GTEx DepMap Descartes 1.53 103.21
DPYSL2 0.0003976 1116 GTEx DepMap Descartes 1.43 76.32
NARS2 0.0003768 1167 GTEx DepMap Descartes 0.09 7.31
LSM4 0.0003222 1326 GTEx DepMap Descartes 0.44 64.21
PBX3 0.0003088 1373 GTEx DepMap Descartes 0.62 58.59
RPS6KA2 0.0002809 1475 GTEx DepMap Descartes 0.23 8.44
MMD 0.0002722 1507 GTEx DepMap Descartes 0.30 31.78
CELF2 0.0002218 1748 GTEx DepMap Descartes 1.64 58.40
RALGDS 0.0002063 1828 GTEx DepMap Descartes 1.46 57.27
GGCT 0.0001934 1900 GTEx DepMap Descartes 0.18 27.04
TBC1D30 0.0001363 2257 GTEx DepMap Descartes 0.06 1.99
QDPR 0.0001336 2276 GTEx DepMap Descartes 0.20 34.50
CETN3 0.0001226 2369 GTEx DepMap Descartes 0.06 11.81
TIAM1 0.0001209 2383 GTEx DepMap Descartes 0.66 22.88
EVL 0.0001036 2539 GTEx DepMap Descartes 1.08 89.20
BEND4 0.0001003 2568 GTEx DepMap Descartes 0.05 1.12
NANOS1 0.0000858 2693 GTEx DepMap Descartes 0.02 1.47
PARP6 0.0000845 2713 GTEx DepMap Descartes 0.42 29.00
CHML 0.0000744 2827 GTEx DepMap Descartes 0.56 17.18
ATP6V0E2 0.0000672 2898 GTEx DepMap Descartes 0.10 11.20
ARL6IP1 0.0000647 2925 GTEx DepMap Descartes 1.95 205.46
IRS2 0.0000606 2974 GTEx DepMap Descartes 1.15 40.00
TMTC4 0.0000489 3125 GTEx DepMap Descartes 0.03 3.03


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 7462.75
Median rank of genes in gene set: 8929
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LIPA 0.0106928 1 GTEx DepMap Descartes 7.20 701.83
APOE 0.0095484 2 GTEx DepMap Descartes 34.27 7483.78
CTSB 0.0081959 4 GTEx DepMap Descartes 24.48 1833.57
GRN 0.0061328 20 GTEx DepMap Descartes 11.60 1336.07
NPC2 0.0051896 29 GTEx DepMap Descartes 6.10 1166.07
CTSC 0.0048188 36 GTEx DepMap Descartes 4.31 237.27
CREG1 0.0040593 45 GTEx DepMap Descartes 4.39 532.32
SGK1 0.0036634 53 GTEx DepMap Descartes 7.94 376.57
HNMT 0.0031470 69 GTEx DepMap Descartes 0.83 88.97
ITM2B 0.0030321 75 GTEx DepMap Descartes 13.89 416.14
PPT1 0.0028685 86 GTEx DepMap Descartes 3.94 222.74
STAT1 0.0026967 95 GTEx DepMap Descartes 2.26 183.90
A2M 0.0024697 111 GTEx DepMap Descartes 5.03 343.78
GNS 0.0022265 134 GTEx DepMap Descartes 2.58 123.99
TSPAN4 0.0021844 141 GTEx DepMap Descartes 0.84 95.17
SLC38A6 0.0021800 143 GTEx DepMap Descartes 0.66 81.53
KCTD12 0.0019091 162 GTEx DepMap Descartes 3.33 167.66
LAMP1 0.0018991 164 GTEx DepMap Descartes 2.35 118.02
SCPEP1 0.0016967 196 GTEx DepMap Descartes 0.60 104.24
RGL1 0.0016938 197 GTEx DepMap Descartes 0.83 53.95
B2M 0.0014314 251 GTEx DepMap Descartes 61.41 7139.16
CYFIP1 0.0014153 258 GTEx DepMap Descartes 1.50 59.29
ATP1B1 0.0013960 261 GTEx DepMap Descartes 2.90 266.23
HEXB 0.0013638 271 GTEx DepMap Descartes 1.25 156.78
CD63 0.0013272 281 GTEx DepMap Descartes 5.95 1292.01
IL13RA1 0.0013214 285 GTEx DepMap Descartes 0.90 60.85
PDGFC 0.0012595 299 GTEx DepMap Descartes 0.29 19.59
ARPC1B 0.0011670 327 GTEx DepMap Descartes 1.54 203.89
SNAP23 0.0011142 350 GTEx DepMap Descartes 0.74 75.52
PYGL 0.0010861 361 GTEx DepMap Descartes 0.35 36.34


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.92e-01
Mean rank of genes in gene set: 6765.58
Median rank of genes in gene set: 6738.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOC1 0.0080386 6 GTEx DepMap Descartes 8.05 2748.16
SCARB1 0.0013544 274 GTEx DepMap Descartes 0.41 22.91
SH3BP5 0.0006666 658 GTEx DepMap Descartes 1.47 119.20
PAPSS2 0.0005551 797 GTEx DepMap Descartes 0.86 50.54
NPC1 0.0004547 994 GTEx DepMap Descartes 0.72 39.09
POR 0.0002730 1503 GTEx DepMap Descartes 0.78 84.09
SH3PXD2B 0.0001821 1967 GTEx DepMap Descartes 0.26 7.87
FDX1 0.0000603 2975 GTEx DepMap Descartes 0.27 21.95
ERN1 0.0000583 3000 GTEx DepMap Descartes 0.80 27.59
GRAMD1B 0.0000087 3657 GTEx DepMap Descartes 0.34 11.50
FDXR -0.0000154 4053 GTEx DepMap Descartes 0.04 5.07
INHA -0.0000444 4724 GTEx DepMap Descartes 0.00 0.00
SGCZ -0.0000544 4981 GTEx DepMap Descartes 0.00 0.00
STAR -0.0000775 5651 GTEx DepMap Descartes 0.00 0.00
DNER -0.0000900 6005 GTEx DepMap Descartes 0.01 1.18
SLC16A9 -0.0000940 6133 GTEx DepMap Descartes 0.00 0.60
TM7SF2 -0.0001025 6357 GTEx DepMap Descartes 0.03 2.15
CYB5B -0.0001120 6634 GTEx DepMap Descartes 0.36 23.05
FRMD5 -0.0001194 6843 GTEx DepMap Descartes 0.02 1.48
FREM2 -0.0001379 7358 GTEx DepMap Descartes 0.03 0.29
SCAP -0.0001663 8097 GTEx DepMap Descartes 0.17 11.48
BAIAP2L1 -0.0001680 8148 GTEx DepMap Descartes 0.00 0.40
DHCR7 -0.0001832 8525 GTEx DepMap Descartes 0.09 7.19
DHCR24 -0.0001966 8825 GTEx DepMap Descartes 0.04 2.72
GSTA4 -0.0002740 10220 GTEx DepMap Descartes 0.06 6.02
JAKMIP2 -0.0002959 10530 GTEx DepMap Descartes 0.05 0.58
PDE10A -0.0003084 10695 GTEx DepMap Descartes 0.02 0.39
MSMO1 -0.0003131 10738 GTEx DepMap Descartes 0.16 18.68
SLC1A2 -0.0003330 10950 GTEx DepMap Descartes 0.04 0.80
HMGCR -0.0003531 11160 GTEx DepMap Descartes 0.20 12.78


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9464.12
Median rank of genes in gene set: 10242
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RYR2 0.0001326 2283 GTEx DepMap Descartes 0.08 3.84
REEP1 -0.0000338 4449 GTEx DepMap Descartes 0.07 5.50
HS3ST5 -0.0000472 4787 GTEx DepMap Descartes 0.03 0.90
ANKFN1 -0.0000646 5258 GTEx DepMap Descartes 0.00 0.16
EPHA6 -0.0001050 6422 GTEx DepMap Descartes 0.00 0.00
KCNB2 -0.0001132 6670 GTEx DepMap Descartes 0.00 0.00
ALK -0.0001153 6723 GTEx DepMap Descartes 0.02 2.04
GAL -0.0001266 7047 GTEx DepMap Descartes 0.01 2.13
PLXNA4 -0.0001475 7626 GTEx DepMap Descartes 0.00 0.10
TMEFF2 -0.0001528 7768 GTEx DepMap Descartes 0.03 0.76
MAB21L2 -0.0001679 8147 GTEx DepMap Descartes 0.04 2.20
PTCHD1 -0.0001737 8302 GTEx DepMap Descartes 0.06 1.39
RPH3A -0.0001863 8590 GTEx DepMap Descartes 0.01 0.21
IL7 -0.0001927 8744 GTEx DepMap Descartes 0.02 2.33
SLC44A5 -0.0002011 8902 GTEx DepMap Descartes 0.00 0.00
EYA4 -0.0002146 9168 GTEx DepMap Descartes 0.01 0.65
NTRK1 -0.0002193 9262 GTEx DepMap Descartes 0.00 0.00
EYA1 -0.0002479 9796 GTEx DepMap Descartes 0.00 0.00
FAT3 -0.0002659 10090 GTEx DepMap Descartes 0.00 0.04
GREM1 -0.0002753 10240 GTEx DepMap Descartes 0.03 0.27
RBFOX1 -0.0002755 10242 GTEx DepMap Descartes 0.01 0.21
CNTFR -0.0002769 10266 GTEx DepMap Descartes 0.00 0.09
ELAVL2 -0.0002789 10293 GTEx DepMap Descartes 0.01 0.46
NPY -0.0002837 10367 GTEx DepMap Descartes 0.30 111.20
CNKSR2 -0.0003004 10600 GTEx DepMap Descartes 0.00 0.44
TMEM132C -0.0003213 10820 GTEx DepMap Descartes 0.00 0.00
GAP43 -0.0003234 10845 GTEx DepMap Descartes 0.37 40.84
ISL1 -0.0003416 11043 GTEx DepMap Descartes 0.04 2.57
CCND1 -0.0003458 11092 GTEx DepMap Descartes 0.66 37.70
MARCH11 -0.0003645 11254 GTEx DepMap Descartes 0.00 NA


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.74e-01
Mean rank of genes in gene set: 7420.03
Median rank of genes in gene set: 7210
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CRHBP 0.0013012 291 GTEx DepMap Descartes 0.12 34.00
PLVAP 0.0000113 3624 GTEx DepMap Descartes 0.51 39.58
SHE 0.0000048 3716 GTEx DepMap Descartes 0.09 3.04
BTNL9 -0.0000217 4184 GTEx DepMap Descartes 0.01 0.79
HYAL2 -0.0000302 4366 GTEx DepMap Descartes 0.09 5.41
FLT4 -0.0000635 5226 GTEx DepMap Descartes 0.03 1.69
EHD3 -0.0000661 5308 GTEx DepMap Descartes 0.03 1.74
CEACAM1 -0.0000841 5837 GTEx DepMap Descartes 0.04 2.09
CYP26B1 -0.0000927 6088 GTEx DepMap Descartes 0.02 3.68
IRX3 -0.0001052 6425 GTEx DepMap Descartes 0.01 1.24
F8 -0.0001128 6659 GTEx DepMap Descartes 0.04 0.74
NR5A2 -0.0001135 6679 GTEx DepMap Descartes 0.00 0.23
NOTCH4 -0.0001142 6695 GTEx DepMap Descartes 0.08 2.24
TEK -0.0001153 6725 GTEx DepMap Descartes 0.02 2.35
ROBO4 -0.0001189 6830 GTEx DepMap Descartes 0.08 3.84
KANK3 -0.0001195 6848 GTEx DepMap Descartes 0.01 1.73
CLDN5 -0.0001271 7055 GTEx DepMap Descartes 0.07 4.11
NPR1 -0.0001273 7059 GTEx DepMap Descartes 0.01 0.30
CHRM3 -0.0001317 7183 GTEx DepMap Descartes 0.00 0.06
ESM1 -0.0001337 7237 GTEx DepMap Descartes 0.01 0.36
TIE1 -0.0001348 7263 GTEx DepMap Descartes 0.15 6.84
RAMP2 -0.0001470 7607 GTEx DepMap Descartes 0.04 11.53
KDR -0.0001473 7621 GTEx DepMap Descartes 0.03 0.54
GALNT15 -0.0001611 7978 GTEx DepMap Descartes 0.03 NA
SLCO2A1 -0.0001664 8098 GTEx DepMap Descartes 0.06 2.38
PODXL -0.0001747 8326 GTEx DepMap Descartes 0.07 2.57
MMRN2 -0.0001951 8792 GTEx DepMap Descartes 0.04 2.23
RASIP1 -0.0001999 8882 GTEx DepMap Descartes 0.04 2.95
MYRIP -0.0002228 9326 GTEx DepMap Descartes 0.03 0.90
CDH5 -0.0002366 9596 GTEx DepMap Descartes 0.06 2.04


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10103.16
Median rank of genes in gene set: 10903
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LAMC3 -0.0000137 4020 GTEx DepMap Descartes 0.01 0.37
RSPO3 -0.0000359 4505 GTEx DepMap Descartes 0.00 NA
ITGA11 -0.0000424 4661 GTEx DepMap Descartes 0.06 0.88
GAS2 -0.0000669 5349 GTEx DepMap Descartes 0.00 0.00
DKK2 -0.0000841 5836 GTEx DepMap Descartes 0.01 1.80
POSTN -0.0001381 7361 GTEx DepMap Descartes 0.06 4.32
LRRC17 -0.0001505 7706 GTEx DepMap Descartes 0.00 0.29
CLDN11 -0.0001578 7892 GTEx DepMap Descartes 0.03 3.99
ABCC9 -0.0001765 8357 GTEx DepMap Descartes 0.03 0.73
GLI2 -0.0001812 8478 GTEx DepMap Descartes 0.01 0.48
HHIP -0.0002035 8948 GTEx DepMap Descartes 0.01 0.21
ADAMTSL3 -0.0002043 8967 GTEx DepMap Descartes 0.02 1.09
EDNRA -0.0002251 9382 GTEx DepMap Descartes 0.03 1.74
SFRP2 -0.0002390 9644 GTEx DepMap Descartes 0.20 21.92
FREM1 -0.0002403 9667 GTEx DepMap Descartes 0.00 0.59
ADAMTS2 -0.0002498 9828 GTEx DepMap Descartes 0.16 3.31
PCDH18 -0.0002500 9830 GTEx DepMap Descartes 0.01 0.28
ACTA2 -0.0002664 10101 GTEx DepMap Descartes 0.36 54.98
CD248 -0.0002873 10414 GTEx DepMap Descartes 0.02 1.49
IGFBP3 -0.0003050 10660 GTEx DepMap Descartes 0.03 1.56
COL27A1 -0.0003258 10875 GTEx DepMap Descartes 0.03 0.85
SCARA5 -0.0003274 10891 GTEx DepMap Descartes 0.04 2.64
PRICKLE1 -0.0003293 10915 GTEx DepMap Descartes 0.03 2.03
LOX -0.0003341 10970 GTEx DepMap Descartes 0.07 3.28
COL1A1 -0.0003441 11069 GTEx DepMap Descartes 17.73 334.41
ELN -0.0003511 11137 GTEx DepMap Descartes 0.18 12.25
PAMR1 -0.0003591 11204 GTEx DepMap Descartes 0.02 3.56
ABCA6 -0.0003599 11214 GTEx DepMap Descartes 0.06 1.13
BICC1 -0.0004176 11649 GTEx DepMap Descartes 0.03 1.71
COL12A1 -0.0004389 11776 GTEx DepMap Descartes 0.15 2.64


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.31e-01
Mean rank of genes in gene set: 7145.47
Median rank of genes in gene set: 7141.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GALNTL6 0.0002663 1539 GTEx DepMap Descartes 0.02 0.54
TIAM1 0.0001209 2383 GTEx DepMap Descartes 0.66 22.88
CCSER1 0.0000655 2918 GTEx DepMap Descartes 0.09 NA
ST18 0.0000581 3004 GTEx DepMap Descartes 0.12 3.42
SLC24A2 0.0000147 3570 GTEx DepMap Descartes 0.00 0.07
GRID2 -0.0000115 3982 GTEx DepMap Descartes 0.01 0.33
GRM7 -0.0000188 4119 GTEx DepMap Descartes 0.00 0.20
KSR2 -0.0000240 4231 GTEx DepMap Descartes 0.01 0.09
CDH18 -0.0000329 4424 GTEx DepMap Descartes 0.00 0.00
SPOCK3 -0.0000482 4813 GTEx DepMap Descartes 0.01 0.59
PACRG -0.0000501 4868 GTEx DepMap Descartes 0.03 2.20
SLC35F3 -0.0000611 5172 GTEx DepMap Descartes 0.00 0.00
TBX20 -0.0000818 5767 GTEx DepMap Descartes 0.00 0.00
PENK -0.0001107 6588 GTEx DepMap Descartes 0.00 0.00
SORCS3 -0.0001123 6643 GTEx DepMap Descartes 0.00 0.00
ARC -0.0001131 6666 GTEx DepMap Descartes 0.33 27.75
MGAT4C -0.0001190 6833 GTEx DepMap Descartes 0.01 0.13
AGBL4 -0.0001209 6891 GTEx DepMap Descartes 0.00 0.00
CDH12 -0.0001257 7018 GTEx DepMap Descartes 0.00 0.00
LAMA3 -0.0001349 7265 GTEx DepMap Descartes 0.00 0.45
KCTD16 -0.0001424 7488 GTEx DepMap Descartes 0.03 0.37
PCSK2 -0.0001490 7660 GTEx DepMap Descartes 0.01 1.14
TENM1 -0.0001560 7840 GTEx DepMap Descartes 0.05 NA
FGF14 -0.0001659 8082 GTEx DepMap Descartes 0.00 0.00
EML6 -0.0001743 8321 GTEx DepMap Descartes 0.01 0.16
SLC18A1 -0.0001873 8619 GTEx DepMap Descartes 0.01 1.09
NTNG1 -0.0001876 8622 GTEx DepMap Descartes 0.01 0.33
CNTN3 -0.0001896 8675 GTEx DepMap Descartes 0.00 0.00
PCSK1N -0.0002226 9324 GTEx DepMap Descartes 0.18 38.58
UNC80 -0.0002309 9492 GTEx DepMap Descartes 0.03 0.72


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.99e-01
Mean rank of genes in gene set: 6273.21
Median rank of genes in gene set: 6016
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BLVRB 0.0032852 66 GTEx DepMap Descartes 1.03 209.57
CAT 0.0008770 478 GTEx DepMap Descartes 0.76 86.19
GCLC 0.0003950 1122 GTEx DepMap Descartes 0.47 28.59
FECH 0.0002927 1435 GTEx DepMap Descartes 0.07 2.71
SPECC1 0.0002832 1466 GTEx DepMap Descartes 0.20 5.18
GYPC 0.0001767 1998 GTEx DepMap Descartes 0.86 135.68
ABCB10 0.0001478 2169 GTEx DepMap Descartes 0.14 8.69
XPO7 0.0000545 3047 GTEx DepMap Descartes 0.21 10.11
SPTB 0.0000518 3085 GTEx DepMap Descartes 0.02 0.70
TRAK2 0.0000512 3088 GTEx DepMap Descartes 0.16 7.74
SLC25A21 -0.0000058 3892 GTEx DepMap Descartes 0.00 0.00
RHD -0.0000310 4386 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000503 4873 GTEx DepMap Descartes 0.01 0.40
ALAS2 -0.0000634 5224 GTEx DepMap Descartes 0.00 0.00
TMCC2 -0.0000903 6016 GTEx DepMap Descartes 0.03 1.71
TFR2 -0.0001354 7275 GTEx DepMap Descartes 0.01 1.04
CPOX -0.0001421 7483 GTEx DepMap Descartes 0.10 11.34
SNCA -0.0001650 8066 GTEx DepMap Descartes 0.12 9.14
RGS6 -0.0001792 8428 GTEx DepMap Descartes 0.00 0.00
SOX6 -0.0001911 8706 GTEx DepMap Descartes 0.03 1.41
SELENBP1 -0.0002287 9435 GTEx DepMap Descartes 0.02 2.26
MICAL2 -0.0002511 9846 GTEx DepMap Descartes 0.21 8.65
ANK1 -0.0002653 10082 GTEx DepMap Descartes 0.01 0.12
MARCH3 -0.0002843 10379 GTEx DepMap Descartes 0.10 NA
EPB41 -0.0003904 11479 GTEx DepMap Descartes 0.22 9.76
TSPAN5 -0.0003993 11541 GTEx DepMap Descartes 0.07 3.51
DENND4A -0.0005074 12078 GTEx DepMap Descartes 0.92 25.81
SLC25A37 -0.0006596 12375 GTEx DepMap Descartes 0.64 35.62
RAPGEF2 -0.0006818 12405 GTEx DepMap Descartes 1.11 32.36
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.38e-24
Mean rank of genes in gene set: 339.79
Median rank of genes in gene set: 69.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LGMN 0.0084108 3 GTEx DepMap Descartes 7.74 951.93
CTSB 0.0081959 4 GTEx DepMap Descartes 24.48 1833.57
CTSD 0.0080343 7 GTEx DepMap Descartes 19.69 2418.32
CD163 0.0074670 11 GTEx DepMap Descartes 4.24 245.25
SLCO2B1 0.0072832 12 GTEx DepMap Descartes 2.32 130.09
CSF1R 0.0069906 13 GTEx DepMap Descartes 3.69 298.03
MS4A4A 0.0066294 15 GTEx DepMap Descartes 2.58 495.21
CTSS 0.0062604 18 GTEx DepMap Descartes 9.08 567.56
CD14 0.0061947 19 GTEx DepMap Descartes 4.69 1018.07
CPVL 0.0059359 22 GTEx DepMap Descartes 3.99 467.94
CD74 0.0055652 25 GTEx DepMap Descartes 174.08 14110.95
CD163L1 0.0055483 26 GTEx DepMap Descartes 0.66 54.05
ADAP2 0.0051791 30 GTEx DepMap Descartes 1.43 204.01
FGL2 0.0050760 31 GTEx DepMap Descartes 6.40 400.16
CYBB 0.0048465 34 GTEx DepMap Descartes 3.33 209.94
CTSC 0.0048188 36 GTEx DepMap Descartes 4.31 237.27
MSR1 0.0040519 46 GTEx DepMap Descartes 2.37 226.77
MERTK 0.0039596 47 GTEx DepMap Descartes 0.54 35.26
SLC1A3 0.0033010 65 GTEx DepMap Descartes 1.22 79.51
MARCH1 0.0030426 74 GTEx DepMap Descartes 0.90 NA
FGD2 0.0025793 99 GTEx DepMap Descartes 0.54 30.14
CST3 0.0022685 131 GTEx DepMap Descartes 20.35 1502.23
HCK 0.0021135 144 GTEx DepMap Descartes 2.31 267.02
ABCA1 0.0021135 145 GTEx DepMap Descartes 3.59 95.33
ITPR2 0.0017438 187 GTEx DepMap Descartes 1.09 28.51
RGL1 0.0016938 197 GTEx DepMap Descartes 0.83 53.95
AXL 0.0016810 199 GTEx DepMap Descartes 1.49 91.55
SLC9A9 0.0014067 260 GTEx DepMap Descartes 0.65 44.38
WWP1 0.0013083 289 GTEx DepMap Descartes 0.37 25.13
FMN1 0.0011585 331 GTEx DepMap Descartes 0.44 11.53


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8494.82
Median rank of genes in gene set: 9084
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
KCTD12 0.0019091 162 GTEx DepMap Descartes 3.33 167.66
MARCKS 0.0002220 1746 GTEx DepMap Descartes 10.01 593.29
GAS7 0.0001078 2505 GTEx DepMap Descartes 0.94 31.36
PMP22 0.0000697 2874 GTEx DepMap Descartes 0.81 105.18
STARD13 0.0000252 3411 GTEx DepMap Descartes 0.22 11.96
IL1RAPL2 -0.0000425 4662 GTEx DepMap Descartes 0.00 0.00
MDGA2 -0.0000743 5557 GTEx DepMap Descartes 0.00 0.42
PTPRZ1 -0.0000961 6197 GTEx DepMap Descartes 0.01 0.22
TRPM3 -0.0000967 6211 GTEx DepMap Descartes 0.01 0.29
LRRTM4 -0.0001095 6543 GTEx DepMap Descartes 0.00 0.00
MPZ -0.0001244 6993 GTEx DepMap Descartes 0.04 6.91
IL1RAPL1 -0.0001246 6996 GTEx DepMap Descartes 0.00 0.00
COL25A1 -0.0001344 7253 GTEx DepMap Descartes 0.00 0.00
ERBB4 -0.0001366 7314 GTEx DepMap Descartes 0.00 0.00
ERBB3 -0.0001512 7729 GTEx DepMap Descartes 0.03 1.08
XKR4 -0.0001692 8188 GTEx DepMap Descartes 0.04 0.38
ADAMTS5 -0.0001697 8203 GTEx DepMap Descartes 0.01 0.36
HMGA2 -0.0001730 8284 GTEx DepMap Descartes 0.00 0.22
PAG1 -0.0001869 8606 GTEx DepMap Descartes 0.90 19.60
PTN -0.0001913 8713 GTEx DepMap Descartes 0.06 6.66
SLC35F1 -0.0001943 8771 GTEx DepMap Descartes 0.01 0.80
PLCE1 -0.0002052 8989 GTEx DepMap Descartes 0.02 1.29
NRXN3 -0.0002152 9179 GTEx DepMap Descartes 0.00 0.04
GRIK3 -0.0002155 9191 GTEx DepMap Descartes 0.00 0.12
DST -0.0002232 9336 GTEx DepMap Descartes 0.90 9.27
EDNRB -0.0002302 9468 GTEx DepMap Descartes 0.09 4.92
SORCS1 -0.0002430 9717 GTEx DepMap Descartes 0.04 1.22
PLP1 -0.0002532 9880 GTEx DepMap Descartes 0.03 2.72
FIGN -0.0002592 9979 GTEx DepMap Descartes 0.03 0.52
GFRA3 -0.0002593 9981 GTEx DepMap Descartes 0.04 6.20


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.24e-01
Mean rank of genes in gene set: 6595.87
Median rank of genes in gene set: 6941
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD84 0.0042484 41 GTEx DepMap Descartes 3.49 133.38
TMSB4X 0.0017424 188 GTEx DepMap Descartes 37.63 5143.27
ACTB 0.0014996 238 GTEx DepMap Descartes 36.15 3298.74
STON2 0.0010896 360 GTEx DepMap Descartes 0.12 8.40
FERMT3 0.0007978 524 GTEx DepMap Descartes 1.11 128.14
TLN1 0.0007912 533 GTEx DepMap Descartes 2.91 84.98
MCTP1 0.0007533 567 GTEx DepMap Descartes 0.66 33.65
ZYX 0.0005364 840 GTEx DepMap Descartes 2.74 313.39
PLEK 0.0004659 969 GTEx DepMap Descartes 7.73 694.90
CD9 0.0003551 1219 GTEx DepMap Descartes 1.08 130.29
LIMS1 0.0002874 1454 GTEx DepMap Descartes 3.02 165.04
UBASH3B 0.0002342 1679 GTEx DepMap Descartes 0.54 17.31
FLI1 0.0001991 1867 GTEx DepMap Descartes 0.26 12.76
P2RX1 0.0000781 2782 GTEx DepMap Descartes 0.09 9.62
TUBB1 0.0000537 3062 GTEx DepMap Descartes 0.03 1.40
ARHGAP6 0.0000300 3339 GTEx DepMap Descartes 0.04 2.96
STOM -0.0000208 4158 GTEx DepMap Descartes 1.84 178.07
MMRN1 -0.0000568 5049 GTEx DepMap Descartes 0.00 0.07
RAB27B -0.0000701 5436 GTEx DepMap Descartes 0.00 0.98
TRPC6 -0.0000742 5555 GTEx DepMap Descartes 0.00 0.23
GP1BA -0.0000800 5718 GTEx DepMap Descartes 0.00 0.26
SLC24A3 -0.0000845 5849 GTEx DepMap Descartes 0.00 0.00
ITGA2B -0.0001226 6941 GTEx DepMap Descartes 0.01 0.48
ITGB3 -0.0001473 7614 GTEx DepMap Descartes 0.00 0.00
PRKAR2B -0.0001683 8158 GTEx DepMap Descartes 0.14 11.22
DOK6 -0.0001756 8341 GTEx DepMap Descartes 0.03 0.74
MED12L -0.0001871 8612 GTEx DepMap Descartes 0.02 0.19
ANGPT1 -0.0002080 9048 GTEx DepMap Descartes 0.01 0.45
SPN -0.0002195 9267 GTEx DepMap Descartes 0.40 10.85
INPP4B -0.0002261 9400 GTEx DepMap Descartes 0.06 1.39


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8700
Median rank of genes in gene set: 10598
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0014314 251 GTEx DepMap Descartes 61.41 7139.16
TMSB10 0.0010750 366 GTEx DepMap Descartes 14.67 7588.78
RCSD1 0.0005242 862 GTEx DepMap Descartes 0.66 32.77
CELF2 0.0002218 1748 GTEx DepMap Descartes 1.64 58.40
SORL1 0.0001583 2116 GTEx DepMap Descartes 1.55 41.37
LCP1 0.0001172 2414 GTEx DepMap Descartes 5.20 281.60
EVL 0.0001036 2539 GTEx DepMap Descartes 1.08 89.20
ITPKB 0.0000533 3069 GTEx DepMap Descartes 1.14 47.47
ANKRD44 0.0000260 3400 GTEx DepMap Descartes 0.40 13.43
ARHGDIB -0.0000369 4529 GTEx DepMap Descartes 4.59 889.19
PLEKHA2 -0.0000637 5237 GTEx DepMap Descartes 1.14 56.92
DOCK10 -0.0000723 5512 GTEx DepMap Descartes 0.64 23.53
ARHGAP15 -0.0001408 7441 GTEx DepMap Descartes 0.23 23.68
RAP1GAP2 -0.0001671 8119 GTEx DepMap Descartes 0.10 3.03
CCND3 -0.0002092 9068 GTEx DepMap Descartes 0.19 15.12
MSN -0.0002235 9344 GTEx DepMap Descartes 2.34 139.16
SCML4 -0.0002782 10286 GTEx DepMap Descartes 0.04 0.87
SKAP1 -0.0002822 10340 GTEx DepMap Descartes 0.03 1.95
MCTP2 -0.0002878 10424 GTEx DepMap Descartes 0.02 0.76
WIPF1 -0.0002952 10522 GTEx DepMap Descartes 1.50 87.49
SAMD3 -0.0002953 10523 GTEx DepMap Descartes 0.01 0.76
IKZF1 -0.0003056 10673 GTEx DepMap Descartes 0.56 23.29
NCALD -0.0003128 10734 GTEx DepMap Descartes 0.04 1.85
SP100 -0.0003153 10763 GTEx DepMap Descartes 0.85 43.47
PTPRC -0.0003306 10928 GTEx DepMap Descartes 3.74 180.83
TOX -0.0003318 10940 GTEx DepMap Descartes 0.03 1.25
MBNL1 -0.0003723 11335 GTEx DepMap Descartes 1.51 55.06
LEF1 -0.0003811 11408 GTEx DepMap Descartes 0.06 4.31
STK39 -0.0003983 11532 GTEx DepMap Descartes 0.06 5.81
PRKCH -0.0004554 11863 GTEx DepMap Descartes 0.24 19.23


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.69e-03
Mean rank of genes in gene set: 967
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
APOE 0.0095484 2 GTEx DepMap Descartes 34.27 7483.78
APOC1 0.0080386 6 GTEx DepMap Descartes 8.05 2748.16
CD5L 0.0062905 17 GTEx DepMap Descartes 2.20 249.66
FTH1 -0.0000028 3843 GTEx DepMap Descartes 55.32 10530.80


ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.88e-03
Mean rank of genes in gene set: 870
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
LST1 0.0024702 110 GTEx DepMap Descartes 1.80 232.12
HPN 0.0003606 1210 GTEx DepMap Descartes 0.10 12.23
SCN1B 0.0003339 1290 GTEx DepMap Descartes 0.44 20.50


Macrophages: Kupffer cells (curated markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.71e-03
Mean rank of genes in gene set: 184
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD5L 0.0062905 17 GTEx DepMap Descartes 2.20 249.66
VCAM1 0.0011057 351 GTEx DepMap Descartes 0.86 47.61