Program: 14. Unknown NFkB.

Program: 14. Unknown NFkB.

Program description and justification of annotation: 14.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 AOAH 0.0229321 acyloxyacyl hydrolase GTEx DepMap Descartes 1.25 1462.72
2 IL18 0.0222444 interleukin 18 GTEx DepMap Descartes 0.77 1242.60
3 SAT1 0.0210541 spermidine/spermine N1-acetyltransferase 1 GTEx DepMap Descartes 3.00 7116.04
4 RBM47 0.0188444 RNA binding motif protein 47 GTEx DepMap Descartes 1.37 790.49
5 SLC9A9 0.0161499 solute carrier family 9 member A9 GTEx DepMap Descartes 0.84 650.69
6 NPL 0.0145672 N-acetylneuraminate pyruvate lyase GTEx DepMap Descartes 0.67 630.08
7 CD74 0.0138495 CD74 molecule GTEx DepMap Descartes 1.27 1028.86
8 PLXDC2 0.0123362 plexin domain containing 2 GTEx DepMap Descartes 1.60 353.29
9 MITF 0.0119390 melanocyte inducing transcription factor GTEx DepMap Descartes 0.72 396.29
10 ARHGAP25 0.0114772 Rho GTPase activating protein 25 GTEx DepMap Descartes 0.38 311.11
11 ITPR2 0.0114407 inositol 1,4,5-trisphosphate receptor type 2 GTEx DepMap Descartes 0.83 181.08
12 SRGN 0.0111735 serglycin GTEx DepMap Descartes 0.63 1350.91
13 ARHGAP15 0.0103456 Rho GTPase activating protein 15 GTEx DepMap Descartes 0.79 655.89
14 ABCA1 0.0103351 ATP binding cassette subfamily A member 1 GTEx DepMap Descartes 0.63 169.49
15 SLC1A3 0.0102776 solute carrier family 1 member 3 GTEx DepMap Descartes 0.30 227.12
16 SYK 0.0102233 spleen associated tyrosine kinase GTEx DepMap Descartes 0.33 163.51
17 MYO1F 0.0100847 myosin IF GTEx DepMap Descartes 0.41 267.69
18 FGD2 0.0100365 FYVE, RhoGEF and PH domain containing 2 GTEx DepMap Descartes 0.23 97.37
19 ZEB2 0.0098892 zinc finger E-box binding homeobox 2 GTEx DepMap Descartes 1.82 516.93
20 LGMN 0.0097330 legumain GTEx DepMap Descartes 0.56 747.63
21 SLCO2B1 0.0096352 solute carrier organic anion transporter family member 2B1 GTEx DepMap Descartes 0.35 172.03
22 MERTK 0.0094157 MER proto-oncogene, tyrosine kinase GTEx DepMap Descartes 0.29 229.61
23 LYN 0.0091288 LYN proto-oncogene, Src family tyrosine kinase GTEx DepMap Descartes 0.41 205.42
24 PLA2G7 0.0090791 phospholipase A2 group VII GTEx DepMap Descartes 0.20 291.58
25 EPB41L2 0.0089929 erythrocyte membrane protein band 4.1 like 2 GTEx DepMap Descartes 0.42 251.50
26 TNFAIP2 0.0089456 TNF alpha induced protein 2 GTEx DepMap Descartes 0.44 269.99
27 PARP14 0.0089410 poly(ADP-ribose) polymerase family member 14 GTEx DepMap Descartes 0.40 127.70
28 ATG7 0.0086705 autophagy related 7 GTEx DepMap Descartes 1.28 651.56
29 RAB20 0.0084975 RAB20, member RAS oncogene family GTEx DepMap Descartes 0.29 549.99
30 LCP2 0.0083127 lymphocyte cytosolic protein 2 GTEx DepMap Descartes 0.25 164.85
31 SAMSN1 0.0081857 SAM domain, SH3 domain and nuclear localization signals 1 GTEx DepMap Descartes 0.30 273.30
32 DOCK2 0.0081480 dedicator of cytokinesis 2 GTEx DepMap Descartes 0.45 181.61
33 RASSF4 0.0081230 Ras association domain family member 4 GTEx DepMap Descartes 0.38 273.30
34 MEF2C 0.0080532 myocyte enhancer factor 2C GTEx DepMap Descartes 0.61 232.26
35 PDGFC 0.0080390 platelet derived growth factor C GTEx DepMap Descartes 0.27 210.77
36 IFI30 0.0079685 IFI30 lysosomal thiol reductase GTEx DepMap Descartes 0.16 220.69
37 ITGAX 0.0079169 integrin subunit alpha X GTEx DepMap Descartes 0.40 224.67
38 CD84 0.0078611 CD84 molecule GTEx DepMap Descartes 0.17 48.54
39 ETV6 0.0078583 ETS variant transcription factor 6 GTEx DepMap Descartes 1.07 478.97
40 SFMBT2 0.0078210 Scm like with four mbt domains 2 GTEx DepMap Descartes 0.83 250.51
41 ADAP2 0.0078164 ArfGAP with dual PH domains 2 GTEx DepMap Descartes 0.38 414.00
42 CD83 0.0077866 CD83 molecule GTEx DepMap Descartes 0.33 386.66
43 ENTPD1 0.0077617 ectonucleoside triphosphate diphosphohydrolase 1 GTEx DepMap Descartes 0.37 80.59
44 PTPRJ 0.0077577 protein tyrosine phosphatase receptor type J GTEx DepMap Descartes 0.59 199.51
45 ARHGAP18 0.0077392 Rho GTPase activating protein 18 GTEx DepMap Descartes 0.36 NA
46 BMP2K 0.0077212 BMP2 inducible kinase GTEx DepMap Descartes 0.62 234.60
47 TNS3 0.0077167 tensin 3 GTEx DepMap Descartes 0.57 215.29
48 IQGAP2 0.0076808 IQ motif containing GTPase activating protein 2 GTEx DepMap Descartes 0.37 167.99
49 GSAP 0.0075742 gamma-secretase activating protein GTEx DepMap Descartes 0.34 NA
50 KYNU 0.0074950 kynureninase GTEx DepMap Descartes 0.26 57.61


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UMAP plots showing activity of gene expression program identified in community:14. Unknown NFkB

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DESCARTES_FETAL_EYE_MICROGLIA 2.47e-19 43.58 21.89 1.84e-17 1.66e-16
16AOAH, SLC9A9, CD74, ARHGAP25, ITPR2, ARHGAP15, MYO1F, FGD2, LGMN, SLCO2B1, MERTK, RAB20, DOCK2, CD84, ADAP2, CD83
 151
FAN_EMBRYONIC_CTX_BIG_GROUPS_MICROGLIA 2.21e-27 39.26 21.44 1.48e-24 1.48e-24
26AOAH, SAT1, SLC9A9, NPL, CD74, PLXDC2, ITPR2, SRGN, SLC1A3, SYK, MYO1F, FGD2, LGMN, SLCO2B1, MERTK, LYN, EPB41L2, SAMSN1, DOCK2, IFI30, ITGAX, CD84, SFMBT2, ADAP2, CD83, ENTPD1
 371
HU_FETAL_RETINA_MICROGLIA 4.66e-27 38.06 20.77 1.56e-24 3.13e-24
26AOAH, SAT1, NPL, CD74, PLXDC2, ARHGAP25, ITPR2, SRGN, SYK, MYO1F, FGD2, LGMN, SLCO2B1, MERTK, LYN, PARP14, LCP2, SAMSN1, DOCK2, MEF2C, ITGAX, CD84, SFMBT2, ADAP2, CD83, ENTPD1
 382
GAO_LARGE_INTESTINE_24W_C11_PANETH_LIKE_CELL 4.77e-24 35.25 19.08 5.95e-22 3.20e-21
23AOAH, SLC9A9, NPL, CD74, SRGN, ABCA1, FGD2, LGMN, SLCO2B1, MERTK, LYN, PLA2G7, TNFAIP2, LCP2, SAMSN1, DOCK2, IFI30, ITGAX, CD84, SFMBT2, ADAP2, CD83, KYNU
 325
ZHONG_PFC_MAJOR_TYPES_MICROGLIA 1.48e-25 32.89 17.98 2.48e-23 9.92e-23
26AOAH, SAT1, SLC9A9, NPL, CD74, PLXDC2, ITPR2, SRGN, SYK, MYO1F, FGD2, LGMN, SLCO2B1, MERTK, LYN, PLA2G7, SAMSN1, DOCK2, RASSF4, IFI30, ITGAX, CD84, SFMBT2, ADAP2, CD83, ENTPD1
 438
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 1.87e-19 33.48 17.40 1.57e-17 1.25e-16
18IL18, SAT1, RBM47, PLXDC2, SLC1A3, FGD2, ZEB2, LGMN, SLCO2B1, MERTK, LYN, EPB41L2, TNFAIP2, RASSF4, ITGAX, CD84, ADAP2, CD83
 228
DESCARTES_FETAL_STOMACH_MYELOID_CELLS 1.31e-11 40.92 16.80 4.88e-10 8.79e-09
9CD74, MYO1F, FGD2, MERTK, IFI30, ITGAX, CD84, ADAP2, CD83
 76
FAN_EMBRYONIC_CTX_MICROGLIA_3 1.02e-06 67.68 15.86 2.29e-05 6.87e-04
4SLC1A3, LGMN, SLCO2B1, MERTK
 20
CUI_DEVELOPING_HEART_C8_MACROPHAGE 1.77e-19 29.91 15.75 1.57e-17 1.19e-16
19AOAH, RBM47, CD74, SRGN, SYK, MYO1F, LGMN, SLCO2B1, LYN, LCP2, SAMSN1, DOCK2, MEF2C, IFI30, ITGAX, ADAP2, CD83, ARHGAP18, IQGAP2
 275
DESCARTES_FETAL_CEREBELLUM_MICROGLIA 1.18e-25 28.20 15.43 2.48e-23 7.94e-23
29AOAH, IL18, RBM47, SLC9A9, NPL, CD74, PLXDC2, MITF, ARHGAP25, ARHGAP15, SYK, MYO1F, FGD2, LGMN, MERTK, LYN, PLA2G7, ATG7, RAB20, LCP2, SAMSN1, DOCK2, ITGAX, CD84, SFMBT2, ADAP2, CD83, ENTPD1, BMP2K
 642
DESCARTES_FETAL_THYMUS_ANTIGEN_PRESENTING_CELLS 2.46e-15 30.74 15.01 1.37e-13 1.65e-12
14IL18, CD74, SRGN, SLC1A3, MYO1F, FGD2, LGMN, SAMSN1, RASSF4, ITGAX, CD84, ADAP2, CD83, KYNU
 172
MANNO_MIDBRAIN_NEUROTYPES_HMGL 5.32e-24 26.71 14.64 5.95e-22 3.57e-21
27IL18, SAT1, RBM47, SLC9A9, NPL, CD74, PLXDC2, ARHGAP25, ITPR2, SRGN, SYK, MYO1F, FGD2, LGMN, SLCO2B1, MERTK, LYN, PARP14, SAMSN1, RASSF4, MEF2C, CD84, SFMBT2, ADAP2, CD83, ENTPD1, BMP2K
 577
DESCARTES_MAIN_FETAL_MICROGLIA 1.14e-13 26.58 12.73 5.46e-12 7.65e-11
13SLC9A9, NPL, PLXDC2, ARHGAP25, ITPR2, SLCO2B1, MERTK, ATG7, SAMSN1, ITGAX, SFMBT2, ENTPD1, PTPRJ
 178
DESCARTES_FETAL_CEREBRUM_MICROGLIA 3.44e-17 18.72 10.07 2.31e-15 2.31e-14
21AOAH, IL18, RBM47, NPL, CD74, ARHGAP15, MYO1F, FGD2, LGMN, MERTK, PLA2G7, ATG7, RAB20, SAMSN1, DOCK2, IFI30, ITGAX, SFMBT2, ADAP2, CD83, ENTPD1
 505
TRAVAGLINI_LUNG_IGSF21_DENDRITIC_CELL 9.74e-07 33.82 9.97 2.25e-05 6.53e-04
5LGMN, SLCO2B1, PDGFC, CD83, ARHGAP18
 46
DESCARTES_FETAL_INTESTINE_MYELOID_CELLS 2.48e-12 20.51 9.86 9.77e-11 1.66e-09
13AOAH, CD74, ITPR2, ABCA1, FGD2, LGMN, MERTK, RAB20, IFI30, ITGAX, ADAP2, CD83, KYNU
 227
TRAVAGLINI_LUNG_CLASSICAL_MONOCYTE_CELL 1.15e-12 18.99 9.34 5.12e-11 7.72e-10
14AOAH, SAT1, RBM47, PLXDC2, SYK, MYO1F, FGD2, ZEB2, LYN, TNFAIP2, MEF2C, IFI30, ENTPD1, KYNU
 270
TRAVAGLINI_LUNG_EREG_DENDRITIC_CELL 4.87e-16 16.24 8.74 2.97e-14 3.27e-13
21SAT1, RBM47, CD74, PLXDC2, SRGN, ABCA1, SLC1A3, ZEB2, LGMN, SLCO2B1, EPB41L2, RAB20, LCP2, SAMSN1, IFI30, ITGAX, ETV6, CD83, ENTPD1, ARHGAP18, KYNU
 579
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 2.35e-10 18.65 8.48 8.31e-09 1.58e-07
11IL18, SAT1, PLXDC2, SRGN, SYK, FGD2, SLCO2B1, LYN, ITGAX, CD84, CD83
 200
DESCARTES_FETAL_MUSCLE_MYELOID_CELLS 3.68e-08 19.51 7.74 1.18e-06 2.47e-05
8RBM47, CD74, FGD2, MERTK, PLA2G7, ADAP2, CD83, KYNU
 130

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.24e-04 8.78 3.02 6.18e-03 6.18e-03
6IL18, SAT1, ABCA1, TNFAIP2, CD83, KYNU
 200
HALLMARK_INTERFERON_GAMMA_RESPONSE 1.08e-03 7.12 2.18 1.35e-02 5.40e-02
5CD74, TNFAIP2, PARP14, LCP2, IFI30
 200
HALLMARK_COMPLEMENT 1.08e-03 7.12 2.18 1.35e-02 5.40e-02
5LGMN, LYN, PLA2G7, LCP2, KYNU
 200
HALLMARK_ALLOGRAFT_REJECTION 1.08e-03 7.12 2.18 1.35e-02 5.40e-02
5IL18, CD74, SRGN, LYN, LCP2
 200
HALLMARK_INTERFERON_ALPHA_RESPONSE 6.61e-03 8.48 1.66 5.51e-02 3.30e-01
3CD74, PARP14, IFI30
 97
HALLMARK_ANDROGEN_RESPONSE 7.18e-03 8.22 1.61 5.51e-02 3.59e-01
3SAT1, MERTK, IQGAP2
 100
HALLMARK_INFLAMMATORY_RESPONSE 7.71e-03 5.55 1.44 5.51e-02 3.85e-01
4IL18, ABCA1, LYN, LCP2
 200
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 7.11e-01 1.00e+00
2IL18, SAT1
 161
HALLMARK_MITOTIC_SPINDLE 1.83e-01 2.64 0.31 7.11e-01 1.00e+00
2EPB41L2, DOCK2
 199
HALLMARK_APICAL_JUNCTION 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2SYK, EPB41L2
 200
HALLMARK_MTORC1_SIGNALING 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2LGMN, IFI30
 200
HALLMARK_P53_PATHWAY 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2SAT1, IFI30
 200
HALLMARK_APICAL_SURFACE 1.61e-01 5.93 0.14 7.11e-01 1.00e+00
1LYN
 44
HALLMARK_CHOLESTEROL_HOMEOSTASIS 2.55e-01 3.49 0.09 9.11e-01 1.00e+00
1LGMN
 74
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 9.43e-01 1.00e+00
1PDGFC
 87
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 9.43e-01 1.00e+00
1ABCA1
 96
HALLMARK_PI3K_AKT_MTOR_SIGNALING 3.41e-01 2.45 0.06 9.43e-01 1.00e+00
1ITPR2
 105
HALLMARK_BILE_ACID_METABOLISM 3.59e-01 2.30 0.06 9.43e-01 1.00e+00
1ABCA1
 112
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 9.43e-01 1.00e+00
1LGMN
 138
HALLMARK_UV_RESPONSE_UP 4.66e-01 1.62 0.04 9.43e-01 1.00e+00
1LYN
 158

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 3.74e-03 10.49 2.04 3.98e-01 6.95e-01
3SYK, LYN, LCP2
 79
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 5.05e-03 9.38 1.83 3.98e-01 9.39e-01
3CD74, LGMN, IFI30
 88
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 6.42e-03 8.57 1.68 3.98e-01 1.00e+00
3SYK, LYN, DOCK2
 96
KEGG_LONG_TERM_DEPRESSION 3.13e-02 7.66 0.88 1.00e+00 1.00e+00
2ITPR2, LYN
 70
KEGG_MELANOMA 3.21e-02 7.55 0.87 1.00e+00 1.00e+00
2MITF, PDGFC
 71
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 3.55e-02 7.13 0.82 1.00e+00 1.00e+00
2SYK, LYN
 75
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.07e-02 3.80 0.75 1.00e+00 1.00e+00
3PDGFC, ITGAX, IQGAP2
 213
KEGG_GAP_JUNCTION 4.93e-02 5.92 0.69 1.00e+00 1.00e+00
2ITPR2, PDGFC
 90
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.01e-01 3.86 0.45 1.00e+00 1.00e+00
2SYK, LCP2
 137
KEGG_CHEMOKINE_SIGNALING_PATHWAY 1.70e-01 2.79 0.33 1.00e+00 1.00e+00
2LYN, DOCK2
 189
KEGG_DORSO_VENTRAL_AXIS_FORMATION 9.13e-02 11.08 0.26 1.00e+00 1.00e+00
1ETV6
 24
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 2.77e-01 1.98 0.23 1.00e+00 1.00e+00
2IL18, PDGFC
 265
KEGG_ETHER_LIPID_METABOLISM 1.23e-01 7.97 0.19 1.00e+00 1.00e+00
1PLA2G7
 33
KEGG_REGULATION_OF_AUTOPHAGY 1.30e-01 7.50 0.18 1.00e+00 1.00e+00
1ATG7
 35
KEGG_TRYPTOPHAN_METABOLISM 1.47e-01 6.54 0.16 1.00e+00 1.00e+00
1KYNU
 40
KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1NPL
 44
KEGG_ABC_TRANSPORTERS 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1ABCA1
 44
KEGG_ARGININE_AND_PROLINE_METABOLISM 1.94e-01 4.81 0.12 1.00e+00 1.00e+00
1SAT1
 54
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1IL18
 55
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1IL18
 62

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2q22 2.45e-03 12.27 2.38 6.81e-01 6.81e-01
3ARHGAP15, ZEB2, KYNU
 68
chr6p23 5.81e-02 18.20 0.42 1.00e+00 1.00e+00
1CD83
 15
chr5q35 2.16e-01 2.37 0.28 1.00e+00 1.00e+00
2LCP2, DOCK2
 222
chr3p13 1.47e-01 6.54 0.16 1.00e+00 1.00e+00
1MITF
 40
chr21q11 1.67e-01 5.67 0.14 1.00e+00 1.00e+00
1SAMSN1
 46
chr10p14 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1SFMBT2
 47
chr14q32 1.00e+00 0.96 0.11 1.00e+00 1.00e+00
2LGMN, TNFAIP2
 546
chr7p12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1TNS3
 58
chr2q13 2.09e-01 4.40 0.11 1.00e+00 1.00e+00
1MERTK
 59
chr4p14 2.25e-01 4.05 0.10 1.00e+00 1.00e+00
1RBM47
 64
chr12p11 2.64e-01 3.36 0.08 1.00e+00 1.00e+00
1ITPR2
 77
chr19p13 1.00e+00 0.68 0.08 1.00e+00 1.00e+00
2MYO1F, IFI30
 773
chr8q12 2.95e-01 2.93 0.07 1.00e+00 1.00e+00
1LYN
 88
chr6q23 3.44e-01 2.43 0.06 1.00e+00 1.00e+00
1EPB41L2
 106
chr5q33 3.52e-01 2.36 0.06 1.00e+00 1.00e+00
1CD74
 109
chr4q32 3.62e-01 2.28 0.06 1.00e+00 1.00e+00
1PDGFC
 113
chr6q22 3.77e-01 2.16 0.05 1.00e+00 1.00e+00
1ARHGAP18
 119
chr5p13 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1SLC1A3
 128
chr9q31 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1ABCA1
 128
chr5q14 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1MEF2C
 130

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
LXR_DR4_Q3 4.88e-04 12.21 3.12 1.56e-01 5.53e-01
4MITF, ABCA1, MEF2C, ETV6
 93
ELF1_Q6 3.96e-04 7.01 2.42 1.56e-01 4.49e-01
6SAT1, SLC9A9, MITF, ITPR2, FGD2, SAMSN1
 249
ETS1_B 5.80e-04 6.51 2.25 1.56e-01 6.58e-01
6SLC9A9, ITPR2, ARHGAP15, LYN, LCP2, ETV6
 268
HNF3ALPHA_Q6 1.36e-03 6.74 2.07 2.58e-01 1.00e+00
5IL18, RBM47, SRGN, LCP2, MEF2C
 211
RGAGGAARY_PU1_Q6 6.88e-04 4.70 1.89 1.56e-01 7.80e-01
8ITPR2, FGD2, LYN, RAB20, LCP2, SAMSN1, ETV6, PTPRJ
 515
BACH2_TARGET_GENES 6.32e-05 3.56 1.88 7.16e-02 7.16e-02
18RBM47, ARHGAP25, SRGN, ARHGAP15, SYK, ZEB2, SLCO2B1, LYN, PARP14, SAMSN1, MEF2C, IFI30, ITGAX, CD84, ETV6, TNS3, IQGAP2, GSAP
 1998
PAX4_02 2.42e-03 5.88 1.81 3.43e-01 1.00e+00
5SAT1, MITF, ARHGAP15, ETV6, KYNU
 241
ETS_Q4 2.92e-03 5.62 1.73 3.68e-01 1.00e+00
5SLC9A9, ITPR2, ARHGAP15, LYN, LCP2
 252
HBZ_TARGET_GENES 2.17e-03 3.57 1.52 3.43e-01 1.00e+00
9SLC9A9, SLC1A3, FGD2, SLCO2B1, EPB41L2, SAMSN1, MEF2C, CD83, GSAP
 778
PU1_Q6 1.34e-02 4.69 1.21 7.64e-01 1.00e+00
4IL18, LYN, RAB20, LCP2
 236
IRF_Q6 1.50e-02 4.53 1.17 7.64e-01 1.00e+00
4SAT1, ZEB2, ETV6, KYNU
 244
EVI1_02 1.67e-02 5.95 1.17 7.64e-01 1.00e+00
3RBM47, SLC9A9, KYNU
 137
GATA1_03 1.54e-02 4.49 1.17 7.64e-01 1.00e+00
4NPL, ARHGAP15, ZEB2, MEF2C
 246
FOXO1_01 1.58e-02 4.45 1.16 7.64e-01 1.00e+00
4PLXDC2, MITF, ZEB2, LCP2
 248
ISRE_01 1.69e-02 4.37 1.13 7.64e-01 1.00e+00
4ZEB2, MEF2C, ETV6, KYNU
 253
NFKAPPAB_01 1.73e-02 4.33 1.12 7.64e-01 1.00e+00
4SAMSN1, ETV6, CD83, BMP2K
 255
IRF1_01 1.73e-02 4.33 1.12 7.64e-01 1.00e+00
4SAT1, MITF, PDGFC, KYNU
 255
TFIIA_Q6 1.75e-02 4.31 1.12 7.64e-01 1.00e+00
4SLC9A9, SRGN, ABCA1, ETV6
 256
NFKB_Q6 1.80e-02 4.28 1.11 7.64e-01 1.00e+00
4PLXDC2, SAMSN1, CD83, PTPRJ
 258
PXR_Q2 1.84e-02 4.25 1.10 7.64e-01 1.00e+00
4SAT1, MITF, ARHGAP15, ARHGAP18
 260

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION 3.20e-05 61.17 10.83 3.42e-02 2.40e-01
3IL18, SYK, CD84
 16
GOBP_POSITIVE_REGULATION_OF_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY 3.22e-04 103.49 9.64 9.69e-02 1.00e+00
2LYN, PTPRJ
 7
GOBP_MELANOCYTE_DIFFERENTIATION 1.13e-04 37.87 7.01 8.45e-02 8.45e-01
3MITF, ZEB2, MEF2C
 24
GOBP_REGULATION_OF_MONOCYTE_CHEMOTAXIS 1.62e-04 33.18 6.19 8.86e-02 1.00e+00
3LGMN, LYN, PLA2G7
 27
GOBP_B_CELL_HOMEOSTASIS 1.81e-04 31.85 5.95 8.86e-02 1.00e+00
3CD74, LYN, MEF2C
 28
GOBP_REGULATION_OF_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY 8.35e-04 57.69 5.91 1.40e-01 1.00e+00
2LYN, PTPRJ
 11
GOBP_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 2.22e-04 29.50 5.54 9.25e-02 1.00e+00
3SYK, LYN, CD84
 30
GOBP_NEGATIVE_T_CELL_SELECTION 9.99e-04 51.89 5.39 1.49e-01 1.00e+00
2CD74, DOCK2
 12
GOBP_POSITIVE_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION 1.18e-03 47.19 4.96 1.59e-01 1.00e+00
2IL18, SYK
 13
GOBP_MAST_CELL_ACTIVATION 9.06e-05 19.39 4.91 8.45e-02 6.78e-01
4SYK, LYN, LCP2, CD84
 60
GOBP_PIGMENT_CELL_DIFFERENTIATION 3.24e-04 25.71 4.86 9.69e-02 1.00e+00
3MITF, ZEB2, MEF2C
 34
GOBP_POSITIVE_THYMIC_T_CELL_SELECTION 1.37e-03 43.30 4.59 1.67e-01 1.00e+00
2CD74, DOCK2
 14
GOBP_ALPHA_BETA_T_CELL_PROLIFERATION 4.17e-04 23.45 4.45 1.11e-01 1.00e+00
3IL18, SYK, DOCK2
 37
GOBP_REGULATION_OF_MAST_CELL_ACTIVATION 5.65e-04 20.97 4.00 1.27e-01 1.00e+00
3SYK, LYN, CD84
 41
GOBP_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE 1.80e-03 37.11 3.99 1.98e-01 1.00e+00
2IL18, CD74
 16
GOBP_REGULATION_OF_LEUKOCYTE_DEGRANULATION 6.50e-04 19.93 3.81 1.33e-01 1.00e+00
3SYK, LYN, CD84
 43
GOBP_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION 7.02e-06 9.37 3.76 3.42e-02 5.25e-02
8IL18, CD74, SYK, LYN, PARP14, SAMSN1, PDGFC, PTPRJ
 262
GOBP_DEVELOPMENTAL_PIGMENTATION 6.96e-04 19.44 3.72 1.33e-01 1.00e+00
3MITF, ZEB2, MEF2C
 44
GOBP_LEUKOCYTE_HOMEOSTASIS 2.63e-04 14.48 3.69 9.50e-02 1.00e+00
4CD74, MERTK, LYN, MEF2C
 79
GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS 2.76e-04 14.30 3.65 9.50e-02 1.00e+00
4CD74, MERTK, LYN, MEF2C
 80

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 5.03e-13 23.47 11.26 2.45e-09 2.45e-09
13RBM47, NPL, CD74, SYK, LYN, TNFAIP2, RASSF4, MEF2C, IFI30, ITGAX, ADAP2, TNS3, KYNU
 200
GSE11057_PBMC_VS_MEM_CD4_TCELL_UP 9.65e-12 21.32 9.98 2.35e-08 4.70e-08
12AOAH, IL18, SRGN, ZEB2, PLA2G7, TNFAIP2, RASSF4, MEF2C, PDGFC, IFI30, BMP2K, KYNU
 197
GSE10325_CD4_TCELL_VS_MYELOID_DN 2.35e-10 18.65 8.48 2.29e-07 1.15e-06
11SAT1, RBM47, NPL, SYK, LYN, MEF2C, IFI30, ITGAX, ENTPD1, TNS3, KYNU
 200
GSE24634_TEFF_VS_TCONV_DAY3_IN_CULTURE_DN 2.35e-10 18.65 8.48 2.29e-07 1.15e-06
11AOAH, NPL, SYK, MERTK, PDGFC, IFI30, ITGAX, CD84, ADAP2, GSAP, KYNU
 200
GSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY5_UP 2.35e-10 18.65 8.48 2.29e-07 1.15e-06
11NPL, LGMN, SLCO2B1, PLA2G7, EPB41L2, TNFAIP2, RAB20, RASSF4, PDGFC, CD83, BMP2K
 200
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_DN 3.90e-09 16.62 7.30 2.61e-06 1.90e-05
10IL18, SAT1, RBM47, NPL, SLC1A3, SYK, PLA2G7, RAB20, PDGFC, KYNU
 198
GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN 4.29e-09 16.45 7.22 2.61e-06 2.09e-05
10SAT1, NPL, SYK, LYN, TNFAIP2, ATG7, IFI30, ETV6, ADAP2, TNS3
 200
GSE17301_CTRL_VS_48H_ACD3_ACD28_STIM_CD8_TCELL_DN 4.29e-09 16.45 7.22 2.61e-06 2.09e-05
10AOAH, CD74, LYN, PLA2G7, TNFAIP2, RAB20, LCP2, RASSF4, PTPRJ, GSAP
 200
GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD4_TCELL_UP 1.81e-08 16.93 7.12 9.82e-06 8.83e-05
9AOAH, NPL, SLC1A3, SLCO2B1, MERTK, PARP14, LCP2, PDGFC, CD84
 171
GSE6259_33D1_POS_DC_VS_CD4_TCELL_DN 2.32e-08 16.43 6.91 1.04e-05 1.13e-04
9AOAH, NPL, ABCA1, LGMN, SLCO2B1, MERTK, LCP2, PDGFC, CD84
 176
GSE15330_MEGAKARYOCYTE_ERYTHROID_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_UP 2.56e-08 16.23 6.83 1.04e-05 1.25e-04
9RBM47, SRGN, MYO1F, ZEB2, ITGAX, ENTPD1, PTPRJ, ARHGAP18, GSAP
 178
GSE15330_LYMPHOID_MULTIPOTENT_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_IKAROS_KO_DN 2.56e-08 16.23 6.83 1.04e-05 1.25e-04
9RBM47, SRGN, MYO1F, ZEB2, ITGAX, ENTPD1, PTPRJ, ARHGAP18, GSAP
 178
GSE11057_CD4_EFF_MEM_VS_PBMC_DN 5.33e-08 14.83 6.24 1.87e-05 2.60e-04
9AOAH, CD74, PLXDC2, SRGN, SYK, RAB20, PDGFC, ITGAX, BMP2K
 194
GSE36826_WT_VS_IL1R_KO_SKIN_UP 6.08e-08 14.60 6.15 1.87e-05 2.96e-04
9AOAH, SAT1, MITF, FGD2, EPB41L2, TNFAIP2, RAB20, PDGFC, ITGAX
 197
GSE22886_NAIVE_TCELL_VS_DC_DN 6.91e-08 14.37 6.05 1.87e-05 3.36e-04
9RBM47, MITF, SYK, SLCO2B1, PLA2G7, ATG7, ADAP2, ENTPD1, KYNU
 200
GSE29618_MONOCYTE_VS_PDC_DAY7_FLU_VACCINE_UP 6.91e-08 14.37 6.05 1.87e-05 3.36e-04
9AOAH, SAT1, NPL, MYO1F, TNFAIP2, RAB20, IFI30, ADAP2, ENTPD1
 200
GSE23568_ID3_KO_VS_WT_CD8_TCELL_DN 6.91e-08 14.37 6.05 1.87e-05 3.36e-04
9ABCA1, SYK, LGMN, LYN, PLA2G7, MEF2C, IFI30, CD83, BMP2K
 200
GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP 6.91e-08 14.37 6.05 1.87e-05 3.36e-04
9RBM47, MYO1F, ZEB2, SAMSN1, ITGAX, ENTPD1, PTPRJ, ARHGAP18, IQGAP2
 200
GSE21360_PRIMARY_VS_QUATERNARY_MEMORY_CD8_TCELL_UP 3.43e-07 14.34 5.72 8.79e-05 1.67e-03
8CD74, MYO1F, TNFAIP2, RASSF4, CD83, ENTPD1, PTPRJ, TNS3
 174
GSE13946_CTRL_VS_DSS_COLITIS_GD_TCELL_FROM_COLON_UP 4.07e-07 14.01 5.59 9.44e-05 1.98e-03
8RBM47, SRGN, MYO1F, ZEB2, ITGAX, PTPRJ, ARHGAP18, GSAP
 178

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MITF 9 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Binds DNA both as homo- and heterodimers (PMID: 23207919). The structure 4ATI is a homodimer with DNA GTTAGCACATGACCCT.
SYK 16 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-factor
ZEB2 19 Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None
MEF2C 34 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ETV6 39 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CIITA 55 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Chromatin modifier
TRPS1 66 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
TLR4 67 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PREX1 71 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because Vasquerizas 2009 includes it with an x. No DBD and no other data to support being a TF.
HCK 79 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits TP73-mediated transcription activation (PMID: 17535448)
GAS7 88 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 9736752) only shows that it has a proline-rich domain similar to the one in Oct2. No evidence of DNA binding.
RREB1 91 Yes Known motif Monomer or homomultimer In vivo/Misc source None None
CFLAR 96 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
AFF1 97 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Has a putative AT-hook MLL fusion partner
CMKLR1 99 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a G protein-coupled receptor for the chemoattractant adipokine chemerin
FLI1 100 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZFP36L1 103 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 27102483; PMID: 17013884).
PLEK 106 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs
PLSCR1 112 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None PLSCR1 has been demonstrated to bind a GTAACCATGTGGA sequence in the IP3R1 promoter (PMID:16091359), mediated by a specific portion of the protein.
ICAM1 114 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB13_GGCAATTCATCACCCT-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.06 1373.98
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.24, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.24, Macrophage:monocyte-derived:M-CSF: 0.24, DC:monocyte-derived:anti-DC-SIGN_2h: 0.23, DC:monocyte-derived: 0.23, DC:monocyte-derived:AEC-conditioned: 0.23, Macrophage:monocyte-derived: 0.23, Macrophage:monocyte-derived:IL-4/cntrl: 0.23, Macrophage:monocyte-derived:M-CSF/IFNg: 0.23, Endothelial_cells:lymphatic:TNFa_48h: 0.23
NB12_TCAGGATTCGTTACGA-1 Neurons:adrenal_medulla_cell_line 0.13 680.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:skin_fibroblast-derived: 0.16
NB12_CTTTGCGGTGGGTCAA-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.07 542.03
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.2, Macrophage:monocyte-derived:IL-4/cntrl: 0.2, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.2, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.2, Macrophage:monocyte-derived:IL-4/TGFb: 0.19, DC:monocyte-derived:AEC-conditioned: 0.19, DC:monocyte-derived: 0.19, DC:monocyte-derived:AM580: 0.19, DC:monocyte-derived:anti-DC-SIGN_2h: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg: 0.19
NB13_GTTCATTCACATGTGT-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.13 495.82
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.28, Macrophage:monocyte-derived:M-CSF: 0.28, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.28, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.28, Macrophage:monocyte-derived:IL-4/cntrl: 0.28, Macrophage:monocyte-derived:IL-4/TGFb: 0.28, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.27, DC:monocyte-derived:AEC-conditioned: 0.27, Macrophage:Alveolar:B._anthacis_spores: 0.27, Macrophage:Alveolar: 0.27
NB13_TCAACGATCGATAGAA-1 Endothelial_cells:lymphatic:TNFa_48h 0.05 495.01
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.19, Endothelial_cells:lymphatic: 0.18, Endothelial_cells:HUVEC:VEGF: 0.18, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Endothelial_cells:blood_vessel: 0.17, DC:monocyte-derived: 0.17, Endothelial_cells:lymphatic:KSHV: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17
NB13_CGTAGCGGTGTTCTTT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.04 461.60
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.17, Macrophage:monocyte-derived:M-CSF/IFNg: 0.16, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.16, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.16, DC:monocyte-derived:AEC-conditioned: 0.16, Monocyte:leukotriene_D4: 0.16, DC:monocyte-derived:immature: 0.16, DC:monocyte-derived:LPS: 0.16, Macrophage:monocyte-derived: 0.16, Macrophage:Alveolar: 0.16
NB07_CACCACTAGGCGTACA-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.09 417.52
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Macrophage:monocyte-derived:M-CSF/IFNg: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18, DC:monocyte-derived: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.17, Monocyte:leukotriene_D4: 0.17
NB12_GTCGGGTAGTACGCGA-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.08 399.76
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.16, DC:monocyte-derived: 0.16, Macrophage:monocyte-derived:M-CSF/IFNg: 0.16, DC:monocyte-derived:immature: 0.15, Monocyte:leukotriene_D4: 0.15, DC:monocyte-derived:AEC-conditioned: 0.15, Macrophage:monocyte-derived:IL-4/cntrl: 0.15
NB12_GTCCTCATCACCAGGC-1 Neurons:adrenal_medulla_cell_line 0.09 397.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neuroepithelial_cell:ESC-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.12, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.12
NB12_GGTGTTATCCGGCACA-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.11 390.94
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.2, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.2, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.2, DC:monocyte-derived:anti-DC-SIGN_2h: 0.19, DC:monocyte-derived: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18, DC:monocyte-derived:immature: 0.18, DC:monocyte-derived:AM580: 0.18
NB13_CATCCACGTCTAGTCA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.10 388.59
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.23, Macrophage:monocyte-derived:M-CSF: 0.22, DC:monocyte-derived:AEC-conditioned: 0.22, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.22, Monocyte:leukotriene_D4: 0.22, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.21, Monocyte: 0.21, DC:monocyte-derived:LPS: 0.21, Monocyte:anti-FcgRIIB: 0.21, DC:monocyte-derived:anti-DC-SIGN_2h: 0.21
NB13_GACAGAGAGCTAGTCT-1 Macrophage:monocyte-derived:M-CSF 0.07 388.05
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Macrophage:monocyte-derived:M-CSF: 0.18, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.18, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, DC:monocyte-derived: 0.17, DC:monocyte-derived:LPS: 0.17, Macrophage:monocyte-derived:M-CSF/IFNg: 0.17, DC:monocyte-derived:AEC-conditioned: 0.17, DC:monocyte-derived:immature: 0.17, Monocyte:leukotriene_D4: 0.17
NB13_CGCTTCACACATGGGA-1 DC:monocyte-derived:LPS 0.09 386.80
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.19, DC:monocyte-derived:Galectin-1: 0.19, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, DC:monocyte-derived:LPS: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.19, DC:monocyte-derived:AEC-conditioned: 0.19
NB07_AGGTCCGAGCAATATG-1 Monocyte:CD16- 0.08 367.10
Raw ScoresMonocyte:CD16-: 0.26, Monocyte:CD14+: 0.26, Monocyte:CD16+: 0.26, Macrophage:monocyte-derived:M-CSF/IFNg: 0.26, Monocyte: 0.25, Macrophage:monocyte-derived:M-CSF: 0.25, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.25, DC:monocyte-derived:anti-DC-SIGN_2h: 0.25, DC:monocyte-derived: 0.25, Monocyte:leukotriene_D4: 0.25
NB13_ACTTGTTTCCAAACTG-1 DC:monocyte-derived:LPS 0.04 365.23
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.16, DC:monocyte-derived:anti-DC-SIGN_2h: 0.16, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15, Macrophage:monocyte-derived: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.15, Macrophage:monocyte-derived:M-CSF: 0.15, DC:monocyte-derived:LPS: 0.15, Macrophage:Alveolar:B._anthacis_spores: 0.15, DC:monocyte-derived: 0.15, Macrophage:monocyte-derived:IFNa: 0.15
NB06_GTGAAGGAGAGCTATA-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.11 358.00
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.23, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.23, Macrophage:monocyte-derived:M-CSF: 0.22, Macrophage:monocyte-derived:IL-4/cntrl: 0.22, Macrophage:monocyte-derived:IL-4/TGFb: 0.22, Macrophage:monocyte-derived: 0.22, DC:monocyte-derived:anti-DC-SIGN_2h: 0.22, Macrophage:monocyte-derived:IFNa: 0.22, Macrophage:monocyte-derived:S._aureus: 0.22, DC:monocyte-derived: 0.21
NB06_TGTGTTTGTTTGGGCC-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.11 355.79
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.22, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.22, Macrophage:monocyte-derived:M-CSF: 0.22, DC:monocyte-derived: 0.21, DC:monocyte-derived:anti-DC-SIGN_2h: 0.21, Monocyte:leukotriene_D4: 0.21, Macrophage:monocyte-derived:M-CSF/IFNg: 0.21, DC:monocyte-derived:immature: 0.2, Monocyte: 0.2, Macrophage:monocyte-derived:IL-4/cntrl: 0.2
NB01_ACACCCTCATCCGGGT-1 Neurons:adrenal_medulla_cell_line 0.07 341.74
Raw ScoresAstrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:adrenal_medulla_cell_line: 0.17, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, Smooth_muscle_cells:bronchial: 0.12, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.12, Smooth_muscle_cells:bronchial:vit_D: 0.12, DC:monocyte-derived:immature: 0.12, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.12, Embryonic_stem_cells: 0.11
NB13_TTAGGACTCATGCAAC-1 Neurons:adrenal_medulla_cell_line 0.11 329.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, Neurons:Schwann_cell: 0.21, B_cell:Memory: 0.21, T_cell:CD4+_central_memory: 0.2, Pro-B_cell_CD34+: 0.2, T_cell:CD4+: 0.2, T_cell:CD4+_Naive: 0.2
NB07_CTTGGCTAGCCCTAAT-1 Macrophage:monocyte-derived:M-CSF 0.08 323.24
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18, DC:monocyte-derived: 0.17, Macrophage:Alveolar: 0.17, DC:monocyte-derived:immature: 0.17, Monocyte:leukotriene_D4: 0.17
NB13_CTGATCCCATGGTTGT-1 Tissue_stem_cells:BM_MSC 0.09 313.71
Raw ScoresiPS_cells:CRL2097_foreskin: 0.28, Smooth_muscle_cells:bronchial: 0.28, iPS_cells:PDB_fibroblasts: 0.28, Chondrocytes:MSC-derived: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Osteoblasts: 0.27, iPS_cells:skin_fibroblast: 0.27, Fibroblasts:breast: 0.27, iPS_cells:fibroblasts: 0.27, iPS_cells:adipose_stem_cells: 0.27
NB13_TATTACCCACCTCGTT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.10 299.95
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.22, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.22, Macrophage:monocyte-derived:M-CSF: 0.22, Macrophage:monocyte-derived:M-CSF/IFNg: 0.21, Macrophage:monocyte-derived: 0.21, Macrophage:monocyte-derived:IL-4/cntrl: 0.21, DC:monocyte-derived:anti-DC-SIGN_2h: 0.21, DC:monocyte-derived:AEC-conditioned: 0.2, Monocyte:leukotriene_D4: 0.2, Macrophage:monocyte-derived:IL-4/TGFb: 0.2
NB13_AATCGGTCATGGTCAT-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.09 295.45
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, DC:monocyte-derived:AEC-conditioned: 0.18, Monocyte:leukotriene_D4: 0.18, DC:monocyte-derived: 0.18, Monocyte: 0.18, Monocyte:anti-FcgRIIB: 0.18
NB08_AAATGCCCAACCGCCA-1 DC:monocyte-derived:A._fumigatus_germ_tubes_6h 0.10 295.11
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.19, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.18, Macrophage:monocyte-derived:M-CSF: 0.18, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.18, DC:monocyte-derived:Galectin-1: 0.18, Monocyte:S._typhimurium_flagellin: 0.18, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, DC:monocyte-derived:LPS: 0.18, DC:monocyte-derived: 0.18, DC:monocyte-derived:Schuler_treatment: 0.18
NB07_GTACTTTTCATGTGGT-1 DC:monocyte-derived 0.06 295.00
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.15, Macrophage:monocyte-derived:M-CSF/IFNg: 0.15, DC:monocyte-derived:anti-DC-SIGN_2h: 0.14, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.14, DC:monocyte-derived: 0.14, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.14, Monocyte:leukotriene_D4: 0.14, DC:monocyte-derived:immature: 0.13, DC:monocyte-derived:AEC-conditioned: 0.13, DC:monocyte-derived:Galectin-1: 0.13
NB13_ACTTACTCACGTGAGA-1 Neurons:adrenal_medulla_cell_line 0.07 288.31
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.15, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.14, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.14, Neuroepithelial_cell:ESC-derived: 0.14, DC:monocyte-derived:anti-DC-SIGN_2h: 0.14, Macrophage:monocyte-derived:IL-4/cntrl: 0.14, Macrophage:monocyte-derived:IL-4/TGFb: 0.14, Macrophage:monocyte-derived: 0.14, DC:monocyte-derived:AEC-conditioned: 0.14
NB12_CCTTACGAGGACCACA-1 Neurons:adrenal_medulla_cell_line 0.10 287.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neuroepithelial_cell:ESC-derived: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, Embryonic_stem_cells: 0.14, iPS_cells:skin_fibroblast-derived: 0.14
NB07_CATCCACTCTGTGCAA-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.06 286.52
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.14, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.14, DC:monocyte-derived:anti-DC-SIGN_2h: 0.14, Macrophage:monocyte-derived:M-CSF/IFNg: 0.14, DC:monocyte-derived:immature: 0.13, DC:monocyte-derived: 0.13, Monocyte:leukotriene_D4: 0.13, Macrophage:monocyte-derived:IL-4/cntrl: 0.13, Macrophage:monocyte-derived:IL-4/TGFb: 0.13
NB06_GTGTGCGGTTAGGGTG-1 Macrophage:monocyte-derived 0.08 281.26
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Macrophage:monocyte-derived:M-CSF: 0.18, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, Macrophage:monocyte-derived: 0.17, Macrophage:monocyte-derived:IL-4/cntrl: 0.17, Macrophage:monocyte-derived:IL-4/TGFb: 0.17, Monocyte:leukotriene_D4: 0.17, Macrophage:monocyte-derived:IFNa: 0.17, DC:monocyte-derived:LPS: 0.17
NB06_TGACAACCATTGGTAC-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.08 276.47
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.18, DC:monocyte-derived:anti-DC-SIGN_2h: 0.18, Monocyte:leukotriene_D4: 0.18, DC:monocyte-derived: 0.17, DC:monocyte-derived:AEC-conditioned: 0.17, Macrophage:monocyte-derived: 0.17, Monocyte: 0.17, Macrophage:monocyte-derived:M-CSF/IFNg: 0.17
NB13_GAGCAGATCGCCTGTT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.08 275.49
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.16, Macrophage:monocyte-derived:M-CSF: 0.16, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.15, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.15, DC:monocyte-derived:AEC-conditioned: 0.15, Monocyte:leukotriene_D4: 0.15, Macrophage:monocyte-derived:IL-4/cntrl: 0.15, Macrophage:monocyte-derived: 0.15, DC:monocyte-derived:LPS: 0.15
NB06_CGAATGTCAAACCTAC-1 Neurons:adrenal_medulla_cell_line 0.06 270.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.14, Macrophage:monocyte-derived:M-CSF: 0.13, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.13, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.13, DC:monocyte-derived:anti-DC-SIGN_2h: 0.13, Astrocyte:Embryonic_stem_cell-derived: 0.12, DC:monocyte-derived:immature: 0.12, Macrophage:monocyte-derived: 0.12, Monocyte:CXCL4: 0.12, DC:monocyte-derived: 0.12
NB12_AGATCTGCACAAGTAA-1 Neurons:adrenal_medulla_cell_line 0.06 266.27
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Macrophage:monocyte-derived:M-CSF: 0.14, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.14, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.14, DC:monocyte-derived:anti-DC-SIGN_2h: 0.14, Macrophage:monocyte-derived: 0.13, DC:monocyte-derived:LPS: 0.13, Macrophage:monocyte-derived:IL-4/cntrl: 0.13, Macrophage:monocyte-derived:IL-4/TGFb: 0.13
NB07_GGACAGAAGGTGCAAC-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.07 265.42
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.16, Macrophage:monocyte-derived:IL-4/cntrl: 0.16, Macrophage:monocyte-derived:IL-4/TGFb: 0.16, DC:monocyte-derived:Galectin-1: 0.16, Macrophage:monocyte-derived:M-CSF/IFNg: 0.16, DC:monocyte-derived: 0.16, DC:monocyte-derived:LPS: 0.16
NB06_CATCGAAAGTTAAGTG-1 Neurons:adrenal_medulla_cell_line 0.22 260.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_2lox-22: 0.27
NB06_GTCGTAAGTCAAAGCG-1 Neurons:adrenal_medulla_cell_line 0.12 257.25
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.19, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Monocyte:CXCL4: 0.18, Monocyte:MCSF: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, Macrophage:monocyte-derived:IL-4/TGFb: 0.18
NB13_CTGCCTAGTACCAGTT-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.09 253.96
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Macrophage:monocyte-derived:M-CSF: 0.17, DC:monocyte-derived:AEC-conditioned: 0.16, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.16, DC:monocyte-derived:LPS: 0.16, Monocyte:leukotriene_D4: 0.16, Monocyte: 0.16, Macrophage:monocyte-derived:IFNa: 0.16
NB06_TCATTTGAGATCACGG-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.10 249.61
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.23, Macrophage:monocyte-derived:M-CSF: 0.23, Monocyte:leukotriene_D4: 0.22, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.22, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.22, DC:monocyte-derived: 0.22, Macrophage:monocyte-derived:M-CSF/IFNg: 0.21, DC:monocyte-derived:immature: 0.21, Monocyte:anti-FcgRIIB: 0.21, Monocyte: 0.21
NB06_GTTCTCGGTGTTGAGG-1 Macrophage:monocyte-derived:M-CSF 0.07 243.40
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.15, DC:monocyte-derived:anti-DC-SIGN_2h: 0.15, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.15, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.15, DC:monocyte-derived:LPS: 0.15, DC:monocyte-derived:Galectin-1: 0.15, Monocyte:leukotriene_D4: 0.15, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.14, DC:monocyte-derived:immature: 0.14, Macrophage:monocyte-derived: 0.14
NB08_CGAGAAGAGGTGCAAC-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.10 242.62
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.22, Macrophage:monocyte-derived:M-CSF: 0.21, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.21, DC:monocyte-derived:antiCD40/VAF347: 0.21, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.2, DC:monocyte-derived: 0.2, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.2, Monocyte:S._typhimurium_flagellin: 0.2, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.2, DC:monocyte-derived:Galectin-1: 0.2
NB13_TACCTATTCCGCATCT-1 Neurons:adrenal_medulla_cell_line 0.07 241.45
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Endothelial_cells:lymphatic:TNFa_48h: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, Endothelial_cells:lymphatic: 0.19, Neuroepithelial_cell:ESC-derived: 0.18, Endothelial_cells:HUVEC:VEGF: 0.18, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, Endothelial_cells:HUVEC:IL-1b: 0.18, Endothelial_cells:HUVEC: 0.17
NB06_TGCGTGGAGTGTTTGC-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.07 235.74
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, DC:monocyte-derived: 0.17, Macrophage:monocyte-derived:IL-4/TGFb: 0.16, DC:monocyte-derived:AEC-conditioned: 0.16, Monocyte:leukotriene_D4: 0.16, Macrophage:monocyte-derived:IL-4/cntrl: 0.16, Macrophage:monocyte-derived: 0.16
NB06_ATCTGCCAGGCATGGT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.10 233.99
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.23, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.22, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.22, Monocyte:leukotriene_D4: 0.21, DC:monocyte-derived:anti-DC-SIGN_2h: 0.21, DC:monocyte-derived: 0.21, Macrophage:monocyte-derived:IL-4/TGFb: 0.21, Macrophage:monocyte-derived:IL-4/cntrl: 0.21, Monocyte:CXCL4: 0.2, Macrophage:monocyte-derived:M-CSF/IFNg: 0.2
NB06_TTAGGACGTAAGAGAG-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.10 230.65
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.2, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.2, Macrophage:monocyte-derived:M-CSF: 0.2, DC:monocyte-derived:anti-DC-SIGN_2h: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg: 0.19, Macrophage:monocyte-derived:IL-4/TGFb: 0.19, Macrophage:monocyte-derived:IL-4/cntrl: 0.19, DC:monocyte-derived:immature: 0.18, DC:monocyte-derived: 0.18, DC:monocyte-derived:Galectin-1: 0.18
NB13_AACACGTGTATGGTTC-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.08 229.14
Raw ScoresDC:monocyte-derived:Galectin-1: 0.18, DC:monocyte-derived:LPS: 0.18, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.18, Macrophage:Alveolar:B._anthacis_spores: 0.18, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.18, Macrophage:Alveolar: 0.17, DC:monocyte-derived:antiCD40/VAF347: 0.17, Macrophage:monocyte-derived:S._aureus: 0.17, DC:monocyte-derived: 0.17, Macrophage:monocyte-derived:IFNa: 0.17
NB07_CATGACACACAGTCGC-1 Neurons:adrenal_medulla_cell_line 0.12 228.00
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_2lox-22: 0.13
NB12_TTCGAAGAGCACCGCT-1 Macrophage:monocyte-derived:IL-4/Dex/cntrl 0.08 222.89
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.18, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Monocyte:leukotriene_D4: 0.17, DC:monocyte-derived: 0.17, Macrophage:monocyte-derived:M-CSF/IFNg: 0.17, DC:monocyte-derived:LPS: 0.17, DC:monocyte-derived:AEC-conditioned: 0.17, DC:monocyte-derived:Galectin-1: 0.17
NB06_ACCTTTAAGAAAGTGG-1 DC:monocyte-derived:anti-DC-SIGN_2h 0.05 221.49
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Monocyte:leukotriene_D4: 0.16, DC:monocyte-derived:CD40L: 0.16, DC:monocyte-derived:LPS: 0.16, DC:monocyte-derived:Poly(IC): 0.16, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.16, Macrophage:monocyte-derived:IFNa: 0.16, DC:monocyte-derived:AEC-conditioned: 0.16, DC:monocyte-derived:mature: 0.16, Macrophage:monocyte-derived:M-CSF: 0.16
NB06_ACCTTTAAGTCTCCTC-1 Monocyte:CXCL4 0.06 218.84
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/cntrl: 0.19, Macrophage:monocyte-derived:M-CSF: 0.19, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.19, Macrophage:monocyte-derived:M-CSF/IFNg: 0.18, Macrophage:monocyte-derived:IL-4/cntrl: 0.17, Macrophage:monocyte-derived:IL-4/TGFb: 0.17, Monocyte:CXCL4: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, DC:monocyte-derived: 0.17, Monocyte:leukotriene_D4: 0.17
NB06_TAAGTGCAGACGCAAC-1 Monocyte:CD16- 0.07 216.27
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.18, Macrophage:monocyte-derived:M-CSF: 0.18, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.17, Monocyte:leukotriene_D4: 0.17, DC:monocyte-derived:anti-DC-SIGN_2h: 0.17, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.17, Monocyte: 0.17, Monocyte:anti-FcgRIIB: 0.17, Monocyte:CD16-: 0.17, DC:monocyte-derived: 0.17


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.15e-07
Mean rank of genes in gene set: 1065.64
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IL18 0.0222444 2 GTEx DepMap Descartes 0.77 1242.60
ITGAX 0.0079169 37 GTEx DepMap Descartes 0.40 224.67
TLR4 0.0068252 67 GTEx DepMap Descartes 0.08 15.50
CD14 0.0060249 94 GTEx DepMap Descartes 0.24 408.32
CD80 0.0046667 158 GTEx DepMap Descartes 0.06 51.25
IL1B 0.0037254 231 GTEx DepMap Descartes 0.02 44.86
CCL2 0.0011197 1010 GTEx DepMap Descartes 0.07 173.78
CCL5 0.0009241 1228 GTEx DepMap Descartes 0.03 38.39
CXCL16 0.0005395 1913 GTEx DepMap Descartes 0.04 43.21
TNF 0.0005334 1932 GTEx DepMap Descartes 0.01 12.98
IL33 0.0000461 5050 GTEx DepMap Descartes 0.01 2.67


PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.71e-06
Mean rank of genes in gene set: 2072
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD84 0.0078611 38 GTEx DepMap Descartes 0.17 48.54
STAT1 0.0049762 138 GTEx DepMap Descartes 0.37 203.88
IL1B 0.0037254 231 GTEx DepMap Descartes 0.02 44.86
HIF1A 0.0032010 301 GTEx DepMap Descartes 0.80 510.08
ANXA1 0.0023101 465 GTEx DepMap Descartes 0.18 222.63
STAT6 0.0020148 549 GTEx DepMap Descartes 0.08 58.79
IRF1 0.0017817 638 GTEx DepMap Descartes 0.08 38.39
TNFRSF10B 0.0010788 1046 GTEx DepMap Descartes 0.11 75.66
STAT3 0.0008444 1344 GTEx DepMap Descartes 0.42 153.43
CD36 0.0008023 1394 GTEx DepMap Descartes 0.13 33.10
PTGS2 0.0007828 1428 GTEx DepMap Descartes 0.00 0.00
TGFB1 0.0006244 1721 GTEx DepMap Descartes 0.11 87.64
CSF1 0.0003979 2365 GTEx DepMap Descartes 0.02 12.22
SLC27A2 0.0000074 5564 GTEx DepMap Descartes 0.01 17.40
ARG1 -0.0000648 6818 GTEx DepMap Descartes 0.00 0.00
ARG2 -0.0001968 9112 GTEx DepMap Descartes 0.06 29.95


M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.28e-05
Mean rank of genes in gene set: 2543.73
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD84 0.0078611 38 GTEx DepMap Descartes 0.17 48.54
CD14 0.0060249 94 GTEx DepMap Descartes 0.24 408.32
IL1B 0.0037254 231 GTEx DepMap Descartes 0.02 44.86
HIF1A 0.0032010 301 GTEx DepMap Descartes 0.80 510.08
CD274 0.0031362 313 GTEx DepMap Descartes 0.03 16.10
TNFRSF10B 0.0010788 1046 GTEx DepMap Descartes 0.11 75.66
STAT3 0.0008444 1344 GTEx DepMap Descartes 0.42 153.43
CD36 0.0008023 1394 GTEx DepMap Descartes 0.13 33.10
TGFB1 0.0006244 1721 GTEx DepMap Descartes 0.11 87.64
TNF 0.0005334 1932 GTEx DepMap Descartes 0.01 12.98
IL10 0.0004146 2309 GTEx DepMap Descartes 0.00 0.00
VEGFA 0.0000713 4745 GTEx DepMap Descartes 0.10 20.76
NOS2 -0.0000619 6758 GTEx DepMap Descartes 0.00 0.00
ARG1 -0.0000648 6818 GTEx DepMap Descartes 0.00 0.00
ARG2 -0.0001968 9112 GTEx DepMap Descartes 0.06 29.95




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9698.85
Median rank of genes in gene set: 11190
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LYN 0.0091288 23 GTEx DepMap Descartes 0.41 205.42
CELF2 0.0049160 143 GTEx DepMap Descartes 0.69 181.79
DAPK1 0.0046817 157 GTEx DepMap Descartes 0.63 266.49
MYO5A 0.0036141 246 GTEx DepMap Descartes 0.65 125.35
CXCR4 0.0031182 319 GTEx DepMap Descartes 0.18 209.37
EML4 0.0013193 883 GTEx DepMap Descartes 0.47 164.24
FAM107B 0.0011377 993 GTEx DepMap Descartes 0.22 158.94
ST3GAL6 0.0010297 1094 GTEx DepMap Descartes 0.31 170.63
PIK3R1 0.0010189 1105 GTEx DepMap Descartes 0.38 131.47
ATP6V1B2 0.0009285 1224 GTEx DepMap Descartes 0.24 79.18
UCP2 0.0007805 1434 GTEx DepMap Descartes 0.06 85.54
AP1S2 0.0006566 1658 GTEx DepMap Descartes 0.14 73.73
NPY 0.0005524 1878 GTEx DepMap Descartes 3.25 7268.42
GLRX 0.0005383 1916 GTEx DepMap Descartes 0.04 28.87
RPS6KA2 0.0005135 1989 GTEx DepMap Descartes 0.26 69.60
RTN1 0.0005065 2011 GTEx DepMap Descartes 1.67 742.22
GNB1 0.0004588 2155 GTEx DepMap Descartes 0.58 353.00
KLF13 0.0003772 2444 GTEx DepMap Descartes 0.14 35.99
PPP2R3C 0.0003513 2551 GTEx DepMap Descartes 0.18 110.45
PDK1 0.0003165 2719 GTEx DepMap Descartes 0.05 6.89
ABLIM1 0.0003164 2721 GTEx DepMap Descartes 0.21 52.46
SLC35G2 0.0002577 3045 GTEx DepMap Descartes 0.16 NA
FKBP1B 0.0002482 3114 GTEx DepMap Descartes 0.04 32.23
NEFL 0.0001736 3661 GTEx DepMap Descartes 0.08 33.16
PBX3 0.0001389 3991 GTEx DepMap Descartes 0.66 437.12
NFIL3 0.0001336 4037 GTEx DepMap Descartes 0.04 46.97
ANP32A 0.0001326 4046 GTEx DepMap Descartes 0.13 57.99
RALGDS 0.0001214 4161 GTEx DepMap Descartes 0.31 98.69
CETN3 0.0001107 4274 GTEx DepMap Descartes 0.07 46.61
LRRTM2 0.0000874 4519 GTEx DepMap Descartes 0.03 8.52


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.73e-08
Mean rank of genes in gene set: 5370.17
Median rank of genes in gene set: 4623
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLXDC2 0.0123362 8 GTEx DepMap Descartes 1.60 353.29
PDGFC 0.0080390 35 GTEx DepMap Descartes 0.27 210.77
IQGAP2 0.0076808 48 GTEx DepMap Descartes 0.37 167.99
MAML2 0.0073311 54 GTEx DepMap Descartes 1.07 342.34
LITAF 0.0065826 75 GTEx DepMap Descartes 0.39 415.46
HNMT 0.0064507 78 GTEx DepMap Descartes 0.16 134.96
CTSC 0.0061073 89 GTEx DepMap Descartes 0.27 111.98
SASH1 0.0059375 101 GTEx DepMap Descartes 0.33 113.96
ZFP36L1 0.0058105 103 GTEx DepMap Descartes 0.44 433.89
SH3BGRL 0.0055489 109 GTEx DepMap Descartes 0.25 387.89
RAB31 0.0054639 111 GTEx DepMap Descartes 0.34 270.07
PLSCR1 0.0054615 112 GTEx DepMap Descartes 0.19 328.18
B2M 0.0054490 113 GTEx DepMap Descartes 2.00 1685.50
MBNL1 0.0052962 118 GTEx DepMap Descartes 1.04 334.80
CTSB 0.0052640 120 GTEx DepMap Descartes 0.81 633.90
SPRED1 0.0051421 126 GTEx DepMap Descartes 0.42 153.71
TGFBR2 0.0049895 136 GTEx DepMap Descartes 0.27 134.44
STAT1 0.0049762 138 GTEx DepMap Descartes 0.37 203.88
ELF1 0.0045310 171 GTEx DepMap Descartes 0.30 204.30
PEAK1 0.0041366 192 GTEx DepMap Descartes 0.47 NA
SGK1 0.0040046 205 GTEx DepMap Descartes 0.33 198.96
NR3C1 0.0040027 206 GTEx DepMap Descartes 0.41 124.04
BNC2 0.0038906 213 GTEx DepMap Descartes 0.45 92.00
LPP 0.0036328 238 GTEx DepMap Descartes 1.07 130.24
SLC38A6 0.0035463 254 GTEx DepMap Descartes 0.31 270.65
ITGA4 0.0034527 264 GTEx DepMap Descartes 0.10 27.36
FNDC3B 0.0034377 270 GTEx DepMap Descartes 0.74 195.28
PAPSS2 0.0031686 306 GTEx DepMap Descartes 0.14 87.97
MRC2 0.0031225 317 GTEx DepMap Descartes 0.23 114.57
GPR137B 0.0030308 330 GTEx DepMap Descartes 0.19 269.66


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 7651.31
Median rank of genes in gene set: 8759
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PAPSS2 0.0031686 306 GTEx DepMap Descartes 0.14 87.97
ERN1 0.0020118 551 GTEx DepMap Descartes 0.13 32.63
NPC1 0.0018059 632 GTEx DepMap Descartes 0.29 123.55
SH3PXD2B 0.0015887 722 GTEx DepMap Descartes 0.18 45.44
SH3BP5 0.0011177 1014 GTEx DepMap Descartes 0.16 108.94
SCARB1 0.0009491 1195 GTEx DepMap Descartes 0.15 53.94
FDX1 0.0008084 1382 GTEx DepMap Descartes 0.04 22.59
INHA 0.0001212 4165 GTEx DepMap Descartes 0.00 5.49
DHCR24 0.0000962 4425 GTEx DepMap Descartes 0.06 18.14
POR 0.0000936 4446 GTEx DepMap Descartes 0.06 47.32
SCAP 0.0000873 4520 GTEx DepMap Descartes 0.11 39.84
BAIAP2L1 -0.0000407 6316 GTEx DepMap Descartes 0.02 17.34
HMGCS1 -0.0000471 6445 GTEx DepMap Descartes 0.11 37.28
GRAMD1B -0.0000649 6823 GTEx DepMap Descartes 0.05 7.16
STAR -0.0000661 6834 GTEx DepMap Descartes 0.00 1.20
CYB5B -0.0001074 7580 GTEx DepMap Descartes 0.15 56.97
DHCR7 -0.0001453 8260 GTEx DepMap Descartes 0.02 15.63
FREM2 -0.0001536 8422 GTEx DepMap Descartes 0.00 0.19
APOC1 -0.0001960 9096 GTEx DepMap Descartes 0.40 1275.95
FDPS -0.0002281 9531 GTEx DepMap Descartes 0.21 190.27
FDXR -0.0002657 9996 GTEx DepMap Descartes 0.02 7.37
SLC16A9 -0.0002741 10088 GTEx DepMap Descartes 0.08 34.45
TM7SF2 -0.0002975 10333 GTEx DepMap Descartes 0.05 30.57
PEG3 -0.0003166 10525 GTEx DepMap Descartes 0.16 NA
CLU -0.0003435 10729 GTEx DepMap Descartes 0.28 129.77
DNER -0.0004270 11237 GTEx DepMap Descartes 0.09 42.08
HMGCR -0.0004790 11470 GTEx DepMap Descartes 0.04 11.93
LDLR -0.0004861 11499 GTEx DepMap Descartes 0.03 8.34
MSMO1 -0.0005248 11634 GTEx DepMap Descartes 0.05 26.72
SGCZ -0.0006185 11881 GTEx DepMap Descartes 0.18 19.80


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11423.27
Median rank of genes in gene set: 12238
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NPY 0.0005524 1878 GTEx DepMap Descartes 3.25 7268.42
TUBB2A 0.0000574 4911 GTEx DepMap Descartes 0.41 401.38
GAP43 -0.0000758 7012 GTEx DepMap Descartes 0.48 380.87
MAB21L1 -0.0002025 9196 GTEx DepMap Descartes 0.11 45.84
STMN2 -0.0003156 10518 GTEx DepMap Descartes 1.86 1505.71
GAL -0.0003286 10628 GTEx DepMap Descartes 0.39 753.21
NTRK1 -0.0003517 10795 GTEx DepMap Descartes 0.23 92.93
RPH3A -0.0003787 10968 GTEx DepMap Descartes 0.00 1.99
RGMB -0.0004284 11245 GTEx DepMap Descartes 0.18 86.08
FAT3 -0.0004803 11473 GTEx DepMap Descartes 0.20 12.54
BASP1 -0.0005267 11640 GTEx DepMap Descartes 0.53 457.66
CNTFR -0.0005273 11642 GTEx DepMap Descartes 0.12 79.72
GREM1 -0.0005349 11661 GTEx DepMap Descartes 0.00 0.17
MAB21L2 -0.0006184 11880 GTEx DepMap Descartes 0.07 50.85
REEP1 -0.0006236 11892 GTEx DepMap Descartes 0.16 55.36
SLC6A2 -0.0006651 11962 GTEx DepMap Descartes 0.09 36.89
TUBB2B -0.0007456 12075 GTEx DepMap Descartes 1.10 891.62
MLLT11 -0.0008287 12169 GTEx DepMap Descartes 0.29 211.41
PTCHD1 -0.0008336 12175 GTEx DepMap Descartes 0.08 7.09
CCND1 -0.0008831 12216 GTEx DepMap Descartes 0.89 315.44
HS3ST5 -0.0009099 12238 GTEx DepMap Descartes 0.70 212.82
SYNPO2 -0.0009489 12268 GTEx DepMap Descartes 0.28 29.52
KCNB2 -0.0010090 12307 GTEx DepMap Descartes 0.74 223.04
PLXNA4 -0.0010238 12320 GTEx DepMap Descartes 0.19 15.84
ELAVL2 -0.0010240 12321 GTEx DepMap Descartes 0.68 187.69
CNKSR2 -0.0010334 12330 GTEx DepMap Descartes 0.45 53.74
TMEFF2 -0.0011203 12371 GTEx DepMap Descartes 0.08 27.52
TUBA1A -0.0011499 12381 GTEx DepMap Descartes 2.14 1794.26
EYA1 -0.0011860 12393 GTEx DepMap Descartes 0.44 119.81
ANKFN1 -0.0012524 12415 GTEx DepMap Descartes 0.42 86.79


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.97e-01
Mean rank of genes in gene set: 7018.18
Median rank of genes in gene set: 6982.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SHE 0.0015304 752 GTEx DepMap Descartes 0.03 6.91
CRHBP 0.0010709 1057 GTEx DepMap Descartes 0.02 29.62
F8 0.0004375 2223 GTEx DepMap Descartes 0.01 1.25
FLT4 0.0003893 2403 GTEx DepMap Descartes 0.02 5.86
RASIP1 0.0002725 2951 GTEx DepMap Descartes 0.02 15.52
PLVAP 0.0002524 3082 GTEx DepMap Descartes 0.05 37.18
CALCRL 0.0002483 3113 GTEx DepMap Descartes 0.06 14.92
TIE1 0.0002334 3218 GTEx DepMap Descartes 0.03 17.30
IRX3 0.0002141 3361 GTEx DepMap Descartes 0.00 1.13
MMRN2 0.0002128 3370 GTEx DepMap Descartes 0.01 4.18
HYAL2 0.0001498 3895 GTEx DepMap Descartes 0.04 20.69
NOTCH4 0.0000249 5322 GTEx DepMap Descartes 0.06 13.57
BTNL9 0.0000102 5528 GTEx DepMap Descartes 0.01 0.99
CEACAM1 -0.0000080 5780 GTEx DepMap Descartes 0.04 12.61
EHD3 -0.0000309 6152 GTEx DepMap Descartes 0.01 2.83
SLCO2A1 -0.0000421 6350 GTEx DepMap Descartes 0.03 13.52
KANK3 -0.0000447 6395 GTEx DepMap Descartes 0.02 11.19
ROBO4 -0.0000494 6492 GTEx DepMap Descartes 0.01 2.60
GALNT15 -0.0000578 6674 GTEx DepMap Descartes 0.02 NA
TEK -0.0000915 7291 GTEx DepMap Descartes 0.04 8.55
PODXL -0.0001023 7487 GTEx DepMap Descartes 0.05 17.07
KDR -0.0001222 7844 GTEx DepMap Descartes 0.02 2.83
ESM1 -0.0001497 8340 GTEx DepMap Descartes 0.02 8.12
CYP26B1 -0.0001748 8735 GTEx DepMap Descartes 0.01 0.63
CLDN5 -0.0001786 8793 GTEx DepMap Descartes 0.03 6.48
NPR1 -0.0001861 8922 GTEx DepMap Descartes 0.00 0.00
NR5A2 -0.0002450 9736 GTEx DepMap Descartes 0.02 4.99
RAMP2 -0.0002493 9792 GTEx DepMap Descartes 0.05 118.49
CDH5 -0.0002557 9883 GTEx DepMap Descartes 0.01 5.11
MYRIP -0.0002798 10151 GTEx DepMap Descartes 0.10 21.40


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9360.64
Median rank of genes in gene set: 10380.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ABCA6 0.0018837 597 GTEx DepMap Descartes 0.06 18.32
ACTA2 0.0002730 2948 GTEx DepMap Descartes 0.07 125.53
LAMC3 0.0001266 4120 GTEx DepMap Descartes 0.01 3.35
SCARA5 0.0000277 5285 GTEx DepMap Descartes 0.00 1.71
GAS2 0.0000169 5445 GTEx DepMap Descartes 0.07 47.91
ELN -0.0000231 6024 GTEx DepMap Descartes 0.13 58.63
CLDN11 -0.0000412 6329 GTEx DepMap Descartes 0.08 31.69
DCN -0.0000512 6529 GTEx DepMap Descartes 0.06 15.33
LUM -0.0000542 6600 GTEx DepMap Descartes 0.06 58.50
ADAMTSL3 -0.0000816 7107 GTEx DepMap Descartes 0.04 7.79
RSPO3 -0.0000925 7306 GTEx DepMap Descartes 0.00 NA
IGFBP3 -0.0001011 7469 GTEx DepMap Descartes 0.05 32.07
OGN -0.0001053 7537 GTEx DepMap Descartes 0.03 20.35
LRRC17 -0.0001376 8123 GTEx DepMap Descartes 0.02 10.22
CD248 -0.0001819 8856 GTEx DepMap Descartes 0.01 5.38
PRRX1 -0.0002207 9433 GTEx DepMap Descartes 0.05 26.34
COL27A1 -0.0002254 9497 GTEx DepMap Descartes 0.02 7.08
PCDH18 -0.0002407 9680 GTEx DepMap Descartes 0.00 0.00
FREM1 -0.0002452 9741 GTEx DepMap Descartes 0.12 11.46
EDNRA -0.0002470 9758 GTEx DepMap Descartes 0.01 8.28
HHIP -0.0002685 10031 GTEx DepMap Descartes 0.03 5.17
MGP -0.0002862 10216 GTEx DepMap Descartes 0.09 114.99
PAMR1 -0.0003200 10545 GTEx DepMap Descartes 0.03 15.97
ISLR -0.0003251 10596 GTEx DepMap Descartes 0.04 23.84
ABCC9 -0.0003326 10656 GTEx DepMap Descartes 0.01 1.82
GLI2 -0.0003367 10676 GTEx DepMap Descartes 0.02 5.35
PDGFRA -0.0003401 10700 GTEx DepMap Descartes 0.02 2.50
C7 -0.0003479 10765 GTEx DepMap Descartes 0.04 16.98
CCDC80 -0.0003574 10831 GTEx DepMap Descartes 0.04 2.87
DKK2 -0.0004256 11231 GTEx DepMap Descartes 0.03 11.28


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10231.82
Median rank of genes in gene set: 11712.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
AGBL4 0.0003352 2631 GTEx DepMap Descartes 1.47 426.31
ST18 0.0001706 3679 GTEx DepMap Descartes 0.11 38.73
TENM1 0.0001573 3810 GTEx DepMap Descartes 0.47 NA
PENK 0.0000441 5076 GTEx DepMap Descartes 0.00 16.45
CNTN3 0.0000239 5334 GTEx DepMap Descartes 0.03 8.17
CDH12 0.0000237 5341 GTEx DepMap Descartes 0.08 31.10
SLC24A2 0.0000149 5469 GTEx DepMap Descartes 0.04 4.42
C1QL1 -0.0001100 7622 GTEx DepMap Descartes 0.04 33.87
DGKK -0.0001999 9158 GTEx DepMap Descartes 0.01 0.52
SORCS3 -0.0002058 9248 GTEx DepMap Descartes 0.03 5.02
LAMA3 -0.0002149 9361 GTEx DepMap Descartes 0.10 13.54
HTATSF1 -0.0002810 10163 GTEx DepMap Descartes 0.06 43.28
SLC35F3 -0.0003122 10484 GTEx DepMap Descartes 0.10 57.50
TBX20 -0.0003144 10504 GTEx DepMap Descartes 0.10 61.04
CHGA -0.0004575 11385 GTEx DepMap Descartes 0.83 560.36
GCH1 -0.0004612 11402 GTEx DepMap Descartes 0.22 74.27
PACRG -0.0004894 11509 GTEx DepMap Descartes 0.28 176.72
SLC18A1 -0.0005054 11569 GTEx DepMap Descartes 0.10 36.29
ARC -0.0005439 11688 GTEx DepMap Descartes 0.01 1.49
PCSK1N -0.0005626 11737 GTEx DepMap Descartes 0.75 1005.38
KSR2 -0.0006615 11955 GTEx DepMap Descartes 0.23 16.29
TIAM1 -0.0007537 12088 GTEx DepMap Descartes 0.44 83.34
GRM7 -0.0007567 12095 GTEx DepMap Descartes 0.10 39.48
KCTD16 -0.0008383 12180 GTEx DepMap Descartes 0.73 55.92
PCSK2 -0.0009246 12247 GTEx DepMap Descartes 0.10 23.80
CHGB -0.0009610 12278 GTEx DepMap Descartes 0.73 427.93
CDH18 -0.0009649 12281 GTEx DepMap Descartes 0.09 22.55
GALNTL6 -0.0010200 12315 GTEx DepMap Descartes 0.15 54.91
SPOCK3 -0.0010590 12338 GTEx DepMap Descartes 0.08 34.94
MGAT4C -0.0010720 12351 GTEx DepMap Descartes 0.30 11.59


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.01e-01
Mean rank of genes in gene set: 5417.03
Median rank of genes in gene set: 4418
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BLVRB 0.0020441 537 GTEx DepMap Descartes 0.09 168.15
SPECC1 0.0020257 545 GTEx DepMap Descartes 0.10 26.15
MARCH3 0.0020113 552 GTEx DepMap Descartes 0.26 NA
GYPC 0.0010480 1076 GTEx DepMap Descartes 0.02 33.83
DENND4A 0.0006800 1608 GTEx DepMap Descartes 0.52 115.49
CAT 0.0005932 1789 GTEx DepMap Descartes 0.08 90.20
MICAL2 0.0004666 2132 GTEx DepMap Descartes 0.05 18.87
GCLC 0.0004360 2226 GTEx DepMap Descartes 0.10 52.35
TRAK2 0.0003681 2483 GTEx DepMap Descartes 0.09 31.11
RHD 0.0002857 2865 GTEx DepMap Descartes 0.02 13.90
SLC25A37 0.0002269 3271 GTEx DepMap Descartes 0.08 38.98
SLC4A1 0.0001669 3720 GTEx DepMap Descartes 0.00 2.05
SELENBP1 0.0001466 3928 GTEx DepMap Descartes 0.01 12.14
EPB41 0.0001378 4003 GTEx DepMap Descartes 0.38 82.58
ABCB10 0.0000974 4418 GTEx DepMap Descartes 0.08 42.42
SNCA 0.0000886 4498 GTEx DepMap Descartes 0.14 76.31
ALAS2 -0.0000426 6362 GTEx DepMap Descartes 0.00 0.00
RGS6 -0.0000438 6379 GTEx DepMap Descartes 0.01 2.92
FECH -0.0000935 7330 GTEx DepMap Descartes 0.04 10.26
TMCC2 -0.0000967 7391 GTEx DepMap Descartes 0.02 6.21
CPOX -0.0001231 7870 GTEx DepMap Descartes 0.04 34.10
RAPGEF2 -0.0001856 8915 GTEx DepMap Descartes 0.38 81.15
SPTB -0.0002049 9233 GTEx DepMap Descartes 0.06 8.74
SLC25A21 -0.0002390 9659 GTEx DepMap Descartes 0.01 1.24
XPO7 -0.0002435 9717 GTEx DepMap Descartes 0.16 54.54
ANK1 -0.0002626 9959 GTEx DepMap Descartes 0.15 26.64
SOX6 -0.0003701 10912 GTEx DepMap Descartes 0.56 76.95
TFR2 -0.0005154 11604 GTEx DepMap Descartes 0.15 49.01
TSPAN5 -0.0007670 12112 GTEx DepMap Descartes 0.31 99.08
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.20e-21
Mean rank of genes in gene set: 745.84
Median rank of genes in gene set: 99
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC9A9 0.0161499 5 GTEx DepMap Descartes 0.84 650.69
CD74 0.0138495 7 GTEx DepMap Descartes 1.27 1028.86
ITPR2 0.0114407 11 GTEx DepMap Descartes 0.83 181.08
ABCA1 0.0103351 14 GTEx DepMap Descartes 0.63 169.49
SLC1A3 0.0102776 15 GTEx DepMap Descartes 0.30 227.12
FGD2 0.0100365 18 GTEx DepMap Descartes 0.23 97.37
LGMN 0.0097330 20 GTEx DepMap Descartes 0.56 747.63
SLCO2B1 0.0096352 21 GTEx DepMap Descartes 0.35 172.03
MERTK 0.0094157 22 GTEx DepMap Descartes 0.29 229.61
SFMBT2 0.0078210 40 GTEx DepMap Descartes 0.83 250.51
ADAP2 0.0078164 41 GTEx DepMap Descartes 0.38 414.00
ATP8B4 0.0073741 53 GTEx DepMap Descartes 0.22 113.39
MSR1 0.0068753 64 GTEx DepMap Descartes 0.36 323.59
CSF1R 0.0066867 72 GTEx DepMap Descartes 0.18 136.14
CD163L1 0.0065946 74 GTEx DepMap Descartes 0.70 443.25
CYBB 0.0065696 76 GTEx DepMap Descartes 0.12 71.10
HCK 0.0064350 79 GTEx DepMap Descartes 0.20 244.27
CTSC 0.0061073 89 GTEx DepMap Descartes 0.27 111.98
CD14 0.0060249 94 GTEx DepMap Descartes 0.24 408.32
CPVL 0.0057669 104 GTEx DepMap Descartes 0.23 296.07
CTSS 0.0056008 107 GTEx DepMap Descartes 0.23 143.65
CD163 0.0052874 119 GTEx DepMap Descartes 0.12 75.19
CTSB 0.0052640 120 GTEx DepMap Descartes 0.81 633.90
MARCH1 0.0052075 123 GTEx DepMap Descartes 0.42 NA
TGFBI 0.0048448 148 GTEx DepMap Descartes 0.31 226.79
MS4A4A 0.0043754 179 GTEx DepMap Descartes 0.09 155.00
WWP1 0.0042689 185 GTEx DepMap Descartes 0.38 186.10
PTPRE 0.0034424 269 GTEx DepMap Descartes 0.29 123.21
AXL 0.0028865 350 GTEx DepMap Descartes 0.14 83.21
RGL1 0.0027599 374 GTEx DepMap Descartes 0.34 161.35


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7808.82
Median rank of genes in gene set: 8479.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GAS7 0.0061077 88 GTEx DepMap Descartes 0.37 134.44
STARD13 0.0038300 220 GTEx DepMap Descartes 0.28 139.91
PTPRZ1 0.0005706 1847 GTEx DepMap Descartes 0.01 1.13
SLC35F1 0.0005455 1894 GTEx DepMap Descartes 0.05 10.48
IL1RAPL2 0.0004810 2087 GTEx DepMap Descartes 0.05 22.13
EDNRB 0.0003301 2651 GTEx DepMap Descartes 0.01 1.50
PAG1 0.0002667 2987 GTEx DepMap Descartes 0.40 58.20
KCTD12 0.0002308 3243 GTEx DepMap Descartes 0.03 16.14
PLP1 0.0002064 3412 GTEx DepMap Descartes 0.00 2.95
XKR4 0.0001675 3707 GTEx DepMap Descartes 0.17 10.69
COL25A1 0.0001585 3799 GTEx DepMap Descartes 0.01 1.64
GFRA3 0.0001107 4275 GTEx DepMap Descartes 0.13 73.30
MPZ 0.0000797 4625 GTEx DepMap Descartes 0.01 3.14
HMGA2 0.0000666 4802 GTEx DepMap Descartes 0.01 0.96
OLFML2A 0.0000403 5119 GTEx DepMap Descartes 0.00 0.17
ADAMTS5 0.0000303 5254 GTEx DepMap Descartes 0.03 2.65
ERBB3 0.0000269 5295 GTEx DepMap Descartes 0.01 5.11
MDGA2 0.0000240 5332 GTEx DepMap Descartes 0.00 0.00
PMP22 -0.0000745 6990 GTEx DepMap Descartes 0.25 225.58
PLCE1 -0.0000867 7213 GTEx DepMap Descartes 0.05 5.27
LAMA4 -0.0001033 7501 GTEx DepMap Descartes 0.06 13.22
GRIK3 -0.0001534 8418 GTEx DepMap Descartes 0.02 1.60
EGFLAM -0.0001615 8541 GTEx DepMap Descartes 0.06 19.94
PTN -0.0002048 9230 GTEx DepMap Descartes 0.16 136.42
LAMC1 -0.0002162 9376 GTEx DepMap Descartes 0.10 20.94
DST -0.0003440 10733 GTEx DepMap Descartes 1.53 109.15
IL1RAPL1 -0.0003507 10788 GTEx DepMap Descartes 0.12 25.29
COL18A1 -0.0003805 10987 GTEx DepMap Descartes 0.16 53.40
SFRP1 -0.0004160 11175 GTEx DepMap Descartes 0.05 15.33
FIGN -0.0004201 11202 GTEx DepMap Descartes 0.09 9.65


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.82e-03
Mean rank of genes in gene set: 4879.76
Median rank of genes in gene set: 2716
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD84 0.0078611 38 GTEx DepMap Descartes 0.17 48.54
FLI1 0.0059385 100 GTEx DepMap Descartes 0.35 140.91
PLEK 0.0056256 106 GTEx DepMap Descartes 0.15 148.86
MCTP1 0.0043505 180 GTEx DepMap Descartes 0.33 167.92
UBASH3B 0.0037761 225 GTEx DepMap Descartes 0.21 79.18
FERMT3 0.0027960 367 GTEx DepMap Descartes 0.09 102.12
TMSB4X 0.0026427 393 GTEx DepMap Descartes 3.77 3651.93
SLC2A3 0.0020183 548 GTEx DepMap Descartes 0.38 198.31
GSN 0.0019905 556 GTEx DepMap Descartes 0.29 103.13
LIMS1 0.0018734 601 GTEx DepMap Descartes 0.35 187.00
PSTPIP2 0.0018437 615 GTEx DepMap Descartes 0.06 59.51
RAP1B 0.0016109 713 GTEx DepMap Descartes 0.26 45.92
THBS1 0.0009757 1157 GTEx DepMap Descartes 0.17 96.21
MYH9 0.0006891 1594 GTEx DepMap Descartes 0.20 51.89
TLN1 0.0006414 1689 GTEx DepMap Descartes 0.11 23.68
TGFB1 0.0006244 1721 GTEx DepMap Descartes 0.11 87.64
STON2 0.0005812 1812 GTEx DepMap Descartes 0.13 46.83
P2RX1 0.0005467 1890 GTEx DepMap Descartes 0.01 12.95
ZYX 0.0004223 2284 GTEx DepMap Descartes 0.10 106.48
ARHGAP6 0.0003652 2495 GTEx DepMap Descartes 0.05 13.55
MMRN1 0.0003543 2540 GTEx DepMap Descartes 0.01 1.49
SPN 0.0003239 2685 GTEx DepMap Descartes 0.02 6.91
STOM 0.0003171 2716 GTEx DepMap Descartes 0.06 37.99
TPM4 0.0002116 3379 GTEx DepMap Descartes 0.16 74.55
CD9 0.0001810 3606 GTEx DepMap Descartes 0.15 180.92
GP1BA 0.0001391 3988 GTEx DepMap Descartes 0.01 8.18
ITGB3 0.0000383 5142 GTEx DepMap Descartes 0.00 0.00
TRPC6 -0.0000232 6028 GTEx DepMap Descartes 0.01 4.05
INPP4B -0.0000507 6521 GTEx DepMap Descartes 0.36 61.32
VCL -0.0000553 6626 GTEx DepMap Descartes 0.11 28.49


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.05e-08
Mean rank of genes in gene set: 3213.38
Median rank of genes in gene set: 744.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ARHGAP15 0.0103456 13 GTEx DepMap Descartes 0.79 655.89
PTPRC 0.0069138 62 GTEx DepMap Descartes 0.34 159.48
B2M 0.0054490 113 GTEx DepMap Descartes 2.00 1685.50
IKZF1 0.0053083 117 GTEx DepMap Descartes 0.19 80.81
MBNL1 0.0052962 118 GTEx DepMap Descartes 1.04 334.80
CELF2 0.0049160 143 GTEx DepMap Descartes 0.69 181.79
RCSD1 0.0045651 169 GTEx DepMap Descartes 0.15 54.36
SP100 0.0041689 189 GTEx DepMap Descartes 0.26 113.84
ITPKB 0.0041420 191 GTEx DepMap Descartes 0.17 69.60
DOCK10 0.0041210 195 GTEx DepMap Descartes 0.69 222.44
LCP1 0.0037110 233 GTEx DepMap Descartes 0.16 109.13
PRKCH 0.0032513 294 GTEx DepMap Descartes 0.25 143.81
ARID5B 0.0031374 312 GTEx DepMap Descartes 0.33 116.05
WIPF1 0.0031353 314 GTEx DepMap Descartes 0.43 181.29
PLEKHA2 0.0030087 336 GTEx DepMap Descartes 0.16 74.73
SKAP1 0.0026369 395 GTEx DepMap Descartes 0.15 139.11
ANKRD44 0.0023440 461 GTEx DepMap Descartes 0.49 130.82
MSN 0.0019187 579 GTEx DepMap Descartes 0.15 102.41
SAMD3 0.0016882 683 GTEx DepMap Descartes 0.05 29.90
CCND3 0.0015878 723 GTEx DepMap Descartes 0.15 140.10
FOXP1 0.0015733 732 GTEx DepMap Descartes 1.63 299.51
CD44 0.0015263 757 GTEx DepMap Descartes 0.73 259.99
ETS1 0.0013373 872 GTEx DepMap Descartes 0.11 39.04
ARHGDIB 0.0013096 891 GTEx DepMap Descartes 0.04 83.56
LEF1 0.0011859 964 GTEx DepMap Descartes 0.05 15.96
CCL5 0.0009241 1228 GTEx DepMap Descartes 0.03 38.39
MCTP2 0.0006350 1701 GTEx DepMap Descartes 0.05 15.35
PITPNC1 0.0005312 1937 GTEx DepMap Descartes 0.68 183.02
NCALD 0.0004672 2129 GTEx DepMap Descartes 0.23 90.26
SORL1 0.0003298 2655 GTEx DepMap Descartes 0.25 31.02


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.06e-05
Mean rank of genes in gene set: 662
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD74 0.0138495 7 GTEx DepMap Descartes 1.27 1028.86
PTPRC 0.0069138 62 GTEx DepMap Descartes 0.34 159.48
BIRC3 0.0057526 105 GTEx DepMap Descartes 0.20 66.67
B2M 0.0054490 113 GTEx DepMap Descartes 2.00 1685.50
COTL1 0.0015412 749 GTEx DepMap Descartes 0.10 40.09
SMS 0.0006580 1654 GTEx DepMap Descartes 0.33 332.35
ITM2A 0.0005283 1944 GTEx DepMap Descartes 0.02 17.81


T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.42e-03
Mean rank of genes in gene set: 2189.14
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRKCH 0.0032513 294 GTEx DepMap Descartes 0.25 143.81
MALAT1 0.0013022 894 GTEx DepMap Descartes 156.60 31629.25
LEF1 0.0011859 964 GTEx DepMap Descartes 0.05 15.96
CTSW 0.0010398 1085 GTEx DepMap Descartes 0.01 9.41
CD27 0.0002771 2916 GTEx DepMap Descartes 0.01 4.93
NUCB2 0.0001869 3562 GTEx DepMap Descartes 0.08 49.57
CD8A 0.0000045 5609 GTEx DepMap Descartes 0.03 6.21


T cells: Type 1 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.54e-03
Mean rank of genes in gene set: 1481.2
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CEBPB 0.0027237 380 GTEx DepMap Descartes 0.18 290.83
ANXA1 0.0023101 465 GTEx DepMap Descartes 0.18 222.63
CCL5 0.0009241 1228 GTEx DepMap Descartes 0.03 38.39
KLRB1 0.0005340 1929 GTEx DepMap Descartes 0.02 17.11
PRDM16 0.0002071 3404 GTEx DepMap Descartes 0.01 1.16