Program: 7. Cancer Associated Fibroblast: Myofibroblast (POSTN+).

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QQ-plot of gene loadings, averaged over both independent splits of the data
This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

	Gene	Loading	Gene.Name	GTEx	DepMap	Descartes	Mean.Counts	Mean.Tpm
1	POSTN	0.0266853	periostin	GTEx	DepMap	Descartes	7.14	477.97
2	COL1A1	0.0229196	collagen type I alpha 1 chain	GTEx	DepMap	Descartes	41.87	1624.09
3	COL1A2	0.0209718	collagen type I alpha 2 chain	GTEx	DepMap	Descartes	27.68	1068.65
4	FN1	0.0194227	fibronectin 1	GTEx	DepMap	Descartes	21.78	512.24
5	COL6A3	0.0192235	collagen type VI alpha 3 chain	GTEx	DepMap	Descartes	4.23	100.11
6	COL5A1	0.0179003	collagen type V alpha 1 chain	GTEx	DepMap	Descartes	2.72	75.23
7	SULF1	0.0176868	sulfatase 1	GTEx	DepMap	Descartes	1.41	55.43
8	FAP	0.0174162	fibroblast activation protein alpha	GTEx	DepMap	Descartes	0.38	39.38
9	LOX	0.0169898	lysyl oxidase	GTEx	DepMap	Descartes	1.41	65.63
10	THBS2	0.0164673	thrombospondin 2	GTEx	DepMap	Descartes	2.02	90.75
11	LOXL2	0.0162635	lysyl oxidase like 2	GTEx	DepMap	Descartes	1.64	93.14
12	ANGPTL4	0.0160326	angiopoietin like 4	GTEx	DepMap	Descartes	1.67	206.73
13	COL3A1	0.0157377	collagen type III alpha 1 chain	GTEx	DepMap	Descartes	16.03	706.64
14	SERPINE1	0.0148737	serpin family E member 1	GTEx	DepMap	Descartes	2.75	174.26
15	TNFRSF11B	0.0141060	TNF receptor superfamily member 11b	GTEx	DepMap	Descartes	0.37	40.97
16	KRT18	0.0138213	keratin 18	GTEx	DepMap	Descartes	4.64	503.55
17	CCDC80	0.0128195	coiled-coil domain containing 80	GTEx	DepMap	Descartes	5.03	99.53
18	COL6A2	0.0124972	collagen type VI alpha 2 chain	GTEx	DepMap	Descartes	10.27	656.45
19	CREB3L1	0.0120503	cAMP responsive element binding protein 3 like 1	GTEx	DepMap	Descartes	0.53	37.20
20	BGN	0.0120244	biglycan	GTEx	DepMap	Descartes	7.99	756.33
21	TNC	0.0116712	tenascin C	GTEx	DepMap	Descartes	2.52	55.91
22	COL5A2	0.0116344	collagen type V alpha 2 chain	GTEx	DepMap	Descartes	3.14	93.69
23	TIMP1	0.0113753	TIMP metallopeptidase inhibitor 1	GTEx	DepMap	Descartes	59.35	10946.50
24	THBS1	0.0110827	thrombospondin 1	GTEx	DepMap	Descartes	3.06	73.78
25	LGALS1	0.0110307	galectin 1	GTEx	DepMap	Descartes	51.04	16051.62
26	NNMT	0.0109013	nicotinamide N-methyltransferase	GTEx	DepMap	Descartes	3.91	465.14
27	SPARC	0.0108130	secreted protein acidic and cysteine rich	GTEx	DepMap	Descartes	26.81	1596.61
28	FBN1	0.0107290	fibrillin 1	GTEx	DepMap	Descartes	1.39	27.74
29	COL6A1	0.0105974	collagen type VI alpha 1 chain	GTEx	DepMap	Descartes	7.15	347.83
30	SERPINH1	0.0098135	serpin family H member 1	GTEx	DepMap	Descartes	4.13	226.23
31	PLOD2	0.0094017	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	GTEx	DepMap	Descartes	0.93	52.44
32	TAGLN	0.0092982	transgelin	GTEx	DepMap	Descartes	23.97	1108.52
33	RCN3	0.0089240	reticulocalbin 3	GTEx	DepMap	Descartes	1.15	169.86
34	S100A16	0.0089184	S100 calcium binding protein A16	GTEx	DepMap	Descartes	2.91	497.54
35	LTBP2	0.0088818	latent transforming growth factor beta binding protein 2	GTEx	DepMap	Descartes	0.40	10.91
36	MICAL2	0.0085984	microtubule associated monooxygenase, calponin and LIM domain containing 2	GTEx	DepMap	Descartes	0.59	23.13
37	EFEMP1	0.0083028	EGF containing fibulin extracellular matrix protein 1	GTEx	DepMap	Descartes	2.41	176.21
38	FSTL1	0.0082558	follistatin like 1	GTEx	DepMap	Descartes	2.84	99.93
39	ITGA5	0.0079903	integrin subunit alpha 5	GTEx	DepMap	Descartes	1.21	50.88
40	VEGFC	0.0079090	vascular endothelial growth factor C	GTEx	DepMap	Descartes	0.28	27.90
41	INHBA	0.0077292	inhibin subunit beta A	GTEx	DepMap	Descartes	0.85	30.12
42	TPM2	0.0077177	tropomyosin 2	GTEx	DepMap	Descartes	11.38	1297.18
43	KDELR3	0.0075803	KDEL endoplasmic reticulum protein retention receptor 3	GTEx	DepMap	Descartes	0.86	84.24
44	FLNA	0.0075326	filamin A	GTEx	DepMap	Descartes	4.74	112.41
45	VIM	0.0070253	vimentin	GTEx	DepMap	Descartes	62.85	4335.51
46	S100A13	0.0069114	S100 calcium binding protein A13	GTEx	DepMap	Descartes	2.88	292.63
47	PPIC	0.0068987	peptidylprolyl isomerase C	GTEx	DepMap	Descartes	1.30	195.21
48	GPX8	0.0067753	glutathione peroxidase 8 (putative)	GTEx	DepMap	Descartes	0.95	51.12
49	EMILIN1	0.0067363	elastin microfibril interfacer 1	GTEx	DepMap	Descartes	1.66	108.73
50	ADAM12	0.0066620	ADAM metallopeptidase domain 12	GTEx	DepMap	Descartes	0.39	10.36

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UMAP plots showing activity of gene expression program identified in GEP 7. Cancer Associated Fibroblast: Myofibroblast (POSTN+):

Interactive UMAP Plot

Interactive Boxplot

CNV Data procured from inferCNV.
Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
The top cells expressing this GEP (purple)
Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes

mSigDB Cell Types Gene Set:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
DESCARTES_FETAL_EYE_STROMAL_CELLS	5.33e-29	107.51	54.67	1.79e-26	3.57e-26	19POSTN, COL1A1, COL1A2, FN1, COL6A3, COL5A1, LOX, THBS2, COL3A1, COL6A2, CREB3L1, COL5A2, THBS1, SPARC, FBN1, COL6A1, INHBA, KDELR3, EMILIN1	90
MURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL	7.76e-47	103.16	47.55	5.21e-44	5.21e-44	42POSTN, COL1A1, COL1A2, FN1, COL6A3, COL5A1, SULF1, FAP, LOX, THBS2, LOXL2, ANGPTL4, COL3A1, SERPINE1, CCDC80, COL6A2, CREB3L1, BGN, TNC, COL5A2, TIMP1, THBS1, LGALS1, NNMT, SPARC, FBN1, COL6A1, SERPINH1, PLOD2, S100A16, LTBP2, MICAL2, FSTL1, ITGA5, INHBA, TPM2, KDELR3, FLNA, VIM, PPIC, GPX8, ADAM12	680
CUI_DEVELOPING_HEART_COMPACT_VENTRICULAR_CARDIOMYOCYTE	1.70e-21	94.81	44.59	1.63e-19	1.14e-18	14POSTN, COL1A1, COL1A2, FN1, COL6A3, COL5A1, COL3A1, COL6A2, COL5A2, LGALS1, SPARC, FBN1, COL6A1, VIM	65
DESCARTES_FETAL_THYMUS_STROMAL_CELLS	3.98e-27	71.12	37.16	6.67e-25	2.67e-24	20POSTN, COL1A1, COL1A2, COL5A1, LOX, THBS2, COL3A1, CCDC80, CREB3L1, BGN, COL5A2, TIMP1, SPARC, FBN1, COL6A1, RCN3, FSTL1, GPX8, EMILIN1, ADAM12	137
MENON_FETAL_KIDNEY_3_STROMAL_CELLS	4.78e-20	72.37	34.42	3.56e-18	3.21e-17	14POSTN, COL1A1, COL1A2, FN1, COL6A3, COL3A1, TNC, COL5A2, LGALS1, SPARC, SERPINH1, FSTL1, TPM2, VIM	81
CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL	3.69e-21	58.21	28.98	3.10e-19	2.48e-18	16COL1A1, COL1A2, COL6A3, COL5A1, LOX, THBS2, COL6A2, COL5A2, TIMP1, LGALS1, SPARC, FBN1, COL6A1, SERPINH1, RCN3, FSTL1	117
CUI_DEVELOPING_HEART_SMOOTH_MUSCLE_CELL	1.71e-13	70.13	28.03	5.45e-12	1.15e-10	9COL1A1, COL1A2, LOX, COL3A1, CCDC80, BGN, SPARC, RCN3, PPIC	48
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS	2.42e-16	56.26	25.65	1.16e-14	1.62e-13	12POSTN, COL1A1, COL1A2, COL3A1, COL6A2, BGN, TIMP1, LGALS1, SPARC, TAGLN, TPM2, VIM	82
AIZARANI_LIVER_C21_STELLATE_CELLS_1	2.42e-22	43.76	22.88	2.71e-20	1.62e-19	19COL1A1, COL1A2, COL6A3, COL5A1, THBS2, COL3A1, SERPINE1, CCDC80, COL6A2, BGN, TIMP1, THBS1, LGALS1, SPARC, FBN1, COL6A1, EFEMP1, FSTL1, VIM	194
GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR	1.11e-13	40.00	17.89	4.14e-12	7.45e-11	11COL1A1, COL1A2, COL5A1, LOX, THBS2, COL3A1, CCDC80, COL5A2, NNMT, SPARC, RCN3	99
HU_FETAL_RETINA_FIBROBLAST	6.89e-24	31.96	17.40	9.25e-22	4.62e-21	24COL1A1, COL1A2, FN1, COL6A3, COL5A1, SULF1, LOXL2, COL3A1, CCDC80, COL6A2, BGN, COL5A2, TIMP1, LGALS1, SPARC, FBN1, SERPINH1, FSTL1, ITGA5, TPM2, FLNA, S100A13, GPX8, EMILIN1	385
HAY_BONE_MARROW_STROMAL	7.19e-28	30.37	16.45	1.61e-25	4.82e-25	32COL1A1, COL1A2, FN1, COL6A3, COL5A1, SULF1, FAP, LOX, THBS2, ANGPTL4, COL3A1, TNFRSF11B, CCDC80, COL6A2, BGN, TNC, COL5A2, NNMT, FBN1, COL6A1, SERPINH1, TAGLN, RCN3, S100A16, LTBP2, EFEMP1, FSTL1, VEGFC, S100A13, PPIC, GPX8, EMILIN1	765
AIZARANI_LIVER_C33_STELLATE_CELLS_2	4.82e-14	34.59	16.03	1.90e-12	3.23e-11	12COL1A1, COL1A2, COL5A1, COL3A1, COL6A2, BGN, LGALS1, SPARC, COL6A1, TPM2, FLNA, VIM	126
DESCARTES_MAIN_FETAL_STROMAL_CELLS	1.02e-06	67.68	15.86	1.96e-05	6.87e-04	4COL1A1, COL1A2, COL5A1, THBS2	20
FAN_OVARY_CL6_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_2	8.90e-19	27.27	14.37	5.43e-17	5.97e-16	19COL1A1, COL1A2, FN1, COL6A3, COL3A1, CCDC80, COL6A2, BGN, TIMP1, LGALS1, SPARC, COL6A1, SERPINH1, TAGLN, FSTL1, TPM2, VIM, PPIC, EMILIN1	300
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2	1.07e-18	26.99	14.22	5.98e-17	7.18e-16	19COL1A2, FN1, ANGPTL4, COL3A1, CCDC80, COL6A2, BGN, COL5A2, TIMP1, LGALS1, SPARC, COL6A1, SERPINH1, TAGLN, FSTL1, TPM2, FLNA, VIM, ADAM12	303
DESCARTES_FETAL_STOMACH_STROMAL_CELLS	3.99e-08	38.66	12.81	9.23e-07	2.68e-05	6COL1A1, COL6A3, COL3A1, TAGLN, INHBA, EMILIN1	50
RUBENSTEIN_SKELETAL_MUSCLE_FAP_CELLS	1.22e-13	26.46	12.66	4.33e-12	8.22e-11	13COL1A1, COL1A2, FN1, COL6A3, COL3A1, CCDC80, COL6A2, TIMP1, COL6A1, EFEMP1, FSTL1, VIM, S100A13	179
GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS	8.16e-20	22.11	12.02	5.47e-18	5.47e-17	23POSTN, COL1A1, COL1A2, COL6A3, COL5A1, SULF1, LOX, COL3A1, CCDC80, COL6A2, BGN, COL5A2, NNMT, SPARC, FBN1, COL6A1, LTBP2, EFEMP1, FSTL1, ITGA5, TPM2, FLNA, EMILIN1	505
DESCARTES_FETAL_KIDNEY_STROMAL_CELLS	8.10e-12	26.10	11.80	2.36e-10	5.43e-09	11POSTN, COL1A1, COL1A2, SULF1, LOX, THBS2, COL3A1, SPARC, FBN1, LTBP2, KDELR3	146

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mSigDB Hallmark Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	9.53e-51	159.42	84.06	4.76e-49	4.76e-49	34POSTN, COL1A1, COL1A2, FN1, COL6A3, COL5A1, FAP, LOX, THBS2, LOXL2, COL3A1, SERPINE1, TNFRSF11B, COL6A2, BGN, TNC, COL5A2, TIMP1, THBS1, LGALS1, NNMT, SPARC, FBN1, SERPINH1, PLOD2, TAGLN, FSTL1, ITGA5, VEGFC, INHBA, TPM2, FLNA, VIM, ADAM12	200
HALLMARK_ANGIOGENESIS	2.77e-07	44.73	12.98	6.93e-06	1.39e-05	5POSTN, COL3A1, COL5A2, TIMP1, FSTL1	36
HALLMARK_COAGULATION	1.05e-06	15.53	5.78	1.31e-05	5.23e-05	7FN1, SERPINE1, TIMP1, THBS1, SPARC, FBN1, S100A13	138
HALLMARK_MYOGENESIS	9.73e-07	12.40	4.96	1.31e-05	4.87e-05	8COL1A1, COL6A3, COL3A1, COL6A2, SPARC, TAGLN, TPM2, ADAM12	200
HALLMARK_UV_RESPONSE_DN	2.02e-05	12.35	4.23	2.02e-04	1.01e-03	6COL1A1, COL1A2, COL3A1, SERPINE1, COL5A2, EFEMP1	144
HALLMARK_HYPOXIA	1.24e-04	8.78	3.02	1.03e-03	6.18e-03	6COL5A1, LOX, ANGPTL4, SERPINE1, BGN, KDELR3	200
HALLMARK_TGF_BETA_SIGNALING	1.26e-03	15.63	3.02	9.03e-03	6.32e-02	3SERPINE1, THBS1, LTBP2	54
HALLMARK_COMPLEMENT	7.71e-03	5.55	1.44	3.85e-02	3.85e-01	4FN1, SERPINE1, TIMP1, S100A13	200
HALLMARK_INFLAMMATORY_RESPONSE	7.71e-03	5.55	1.44	3.85e-02	3.85e-01	4SERPINE1, TIMP1, ITGA5, INHBA	200
HALLMARK_GLYCOLYSIS	7.71e-03	5.55	1.44	3.85e-02	3.85e-01	4COL5A1, ANGPTL4, PLOD2, KDELR3	200
HALLMARK_APOPTOSIS	2.53e-02	5.05	0.99	1.15e-01	1.00e+00	3KRT18, BGN, TIMP1	161
HALLMARK_TNFA_SIGNALING_VIA_NFKB	4.35e-02	4.05	0.80	1.67e-01	1.00e+00	3SERPINE1, TNC, INHBA	200
HALLMARK_ALLOGRAFT_REJECTION	4.35e-02	4.05	0.80	1.67e-01	1.00e+00	3TIMP1, INHBA, FLNA	200
HALLMARK_APICAL_JUNCTION	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2TNFRSF11B, FBN1	200
HALLMARK_MTORC1_SIGNALING	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2SERPINH1, PLOD2	200
HALLMARK_KRAS_SIGNALING_UP	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2ANGPTL4, INHBA	200
HALLMARK_CHOLESTEROL_HOMEOSTASIS	2.55e-01	3.49	0.09	7.50e-01	1.00e+00	1GPX8	74
HALLMARK_PROTEIN_SECRETION	3.17e-01	2.68	0.07	8.82e-01	1.00e+00	1KRT18	96
HALLMARK_UNFOLDED_PROTEIN_RESPONSE	3.62e-01	2.28	0.06	9.52e-01	1.00e+00	1KDELR3	113
HALLMARK_FATTY_ACID_METABOLISM	4.66e-01	1.62	0.04	1.00e+00	1.00e+00	1LGALS1	158

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KEGG Pathways:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
KEGG_ECM_RECEPTOR_INTERACTION	5.49e-18	61.70	28.84	1.02e-15	1.02e-15	13COL1A1, COL1A2, FN1, COL6A3, COL5A1, THBS2, COL3A1, COL6A2, TNC, COL5A2, THBS1, COL6A1, ITGA5	84
KEGG_FOCAL_ADHESION	6.53e-16	29.09	14.50	6.07e-14	1.21e-13	15COL1A1, COL1A2, FN1, COL6A3, COL5A1, THBS2, COL3A1, COL6A2, TNC, COL5A2, THBS1, COL6A1, ITGA5, VEGFC, FLNA	199
KEGG_TGF_BETA_SIGNALING_PATHWAY	4.74e-03	9.61	1.88	2.94e-01	8.81e-01	3THBS2, THBS1, INHBA	86
KEGG_BLADDER_CANCER	1.20e-02	13.01	1.48	5.59e-01	1.00e+00	2THBS1, VEGFC	42
KEGG_P53_SIGNALING_PATHWAY	2.97e-02	7.89	0.91	1.00e+00	1.00e+00	2SERPINE1, THBS1	68
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	4.26e-02	6.43	0.74	1.00e+00	1.00e+00	2ITGA5, TPM2	83
KEGG_DILATED_CARDIOMYOPATHY	4.93e-02	5.92	0.69	1.00e+00	1.00e+00	2ITGA5, TPM2	90
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	8.44e-02	3.05	0.60	1.00e+00	1.00e+00	3TNFRSF11B, VEGFC, INHBA	265
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	2.03e-01	2.47	0.29	1.00e+00	1.00e+00	2FN1, ITGA5	213
KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	9.13e-02	11.08	0.26	1.00e+00	1.00e+00	1NNMT	24
KEGG_PATHWAYS_IN_CANCER	3.61e-01	1.61	0.19	1.00e+00	1.00e+00	2FN1, VEGFC	325
KEGG_LYSINE_DEGRADATION	1.61e-01	5.93	0.14	1.00e+00	1.00e+00	1PLOD2	44
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION	1.61e-01	5.93	0.14	1.00e+00	1.00e+00	1CREB3L1	44
KEGG_MTOR_SIGNALING_PATHWAY	1.87e-01	5.00	0.12	1.00e+00	1.00e+00	1VEGFC	52
KEGG_VIBRIO_CHOLERAE_INFECTION	1.94e-01	4.81	0.12	1.00e+00	1.00e+00	1KDELR3	54
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	2.00e-01	4.64	0.11	1.00e+00	1.00e+00	1KRT18	56
KEGG_PPAR_SIGNALING_PATHWAY	2.40e-01	3.75	0.09	1.00e+00	1.00e+00	1ANGPTL4	69
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	2.40e-01	3.75	0.09	1.00e+00	1.00e+00	1SERPINE1	69
KEGG_RENAL_CELL_CARCINOMA	2.43e-01	3.70	0.09	1.00e+00	1.00e+00	1VEGFC	70
KEGG_PANCREATIC_CANCER	2.43e-01	3.70	0.09	1.00e+00	1.00e+00	1VEGFC	70

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CHR Positional Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
chr2q32	6.78e-02	4.91	0.57	1.00e+00	1.00e+00	2COL3A1, COL5A2	108
chr5q23	7.11e-02	4.78	0.56	1.00e+00	1.00e+00	2LOX, PPIC	111
chr3q13	1.67e-01	2.82	0.33	1.00e+00	1.00e+00	2CCDC80, FSTL1	187
chr11q23	1.92e-01	2.57	0.30	1.00e+00	1.00e+00	2NNMT, TAGLN	205
chrXq28	1.93e-01	2.55	0.30	1.00e+00	1.00e+00	2BGN, FLNA	206
chr22q13	3.33e-01	1.72	0.20	1.00e+00	1.00e+00	2LGALS1, KDELR3	305
chr21q22	3.99e-01	1.48	0.17	1.00e+00	1.00e+00	2COL6A2, COL6A1	353
chr1q21	6.64e-01	1.34	0.16	1.00e+00	1.00e+00	2S100A16, S100A13	392
chr12q13	6.71e-01	1.29	0.15	1.00e+00	1.00e+00	2KRT18, ITGA5	407
chr15q14	2.00e-01	4.64	0.11	1.00e+00	1.00e+00	1THBS1	56
chr10p13	2.25e-01	4.05	0.10	1.00e+00	1.00e+00	1VIM	64
chr8q13	2.46e-01	3.64	0.09	1.00e+00	1.00e+00	1SULF1	71
chr6q27	2.58e-01	3.45	0.08	1.00e+00	1.00e+00	1THBS2	75
chr13q13	2.67e-01	3.31	0.08	1.00e+00	1.00e+00	1POSTN	78
chr5q11	2.87e-01	3.04	0.07	1.00e+00	1.00e+00	1GPX8	85
chr5q33	3.52e-01	2.36	0.06	1.00e+00	1.00e+00	1SPARC	109
chr2p16	3.64e-01	2.26	0.06	1.00e+00	1.00e+00	1EFEMP1	114
chr2q24	3.91e-01	2.06	0.05	1.00e+00	1.00e+00	1FAP	125
chr2q35	3.94e-01	2.04	0.05	1.00e+00	1.00e+00	1FN1	126
chr8p21	3.99e-01	2.01	0.05	1.00e+00	1.00e+00	1LOXL2	128

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Transcription Factor Targets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
CCAWWNAAGG_SRF_Q4	3.96e-04	12.93	3.31	8.97e-02	4.49e-01	4THBS1, TAGLN, TPM2, FLNA	88
PSMB5_TARGET_GENES	1.71e-04	6.78	2.55	6.46e-02	1.94e-01	7COL1A1, SERPINE1, THBS1, LGALS1, TPM2, FLNA, S100A13	307
SRF_Q6	3.88e-04	7.04	2.43	8.97e-02	4.40e-01	6COL1A1, COL1A2, THBS1, TAGLN, TPM2, FLNA	248
TGGAAA_NFAT_Q4_01	4.33e-05	3.67	1.94	4.90e-02	4.90e-02	18COL1A2, FN1, SULF1, FAP, LOX, TNFRSF11B, CCDC80, LGALS1, SERPINH1, PLOD2, RCN3, LTBP2, FSTL1, VEGFC, INHBA, TPM2, VIM, ADAM12	1934
SRF_Q5_01	1.80e-03	6.31	1.94	1.70e-01	1.00e+00	5COL1A1, THBS1, TAGLN, TPM2, FLNA	225
SRF_Q4	1.98e-03	6.17	1.89	1.73e-01	1.00e+00	5THBS1, SERPINH1, TAGLN, TPM2, FLNA	230
NFAT_Q6	2.78e-03	5.69	1.75	2.16e-01	1.00e+00	5SULF1, FAP, COL3A1, LGALS1, PLOD2	249
SUPT16H_TARGET_GENES	1.68e-04	3.35	1.74	6.46e-02	1.90e-01	17COL1A1, COL1A2, FN1, COL6A3, THBS2, LOXL2, THBS1, LGALS1, NNMT, SPARC, FBN1, SERPINH1, PLOD2, TAGLN, S100A16, TPM2, FLNA	1944
MSX1_01	4.87e-03	6.36	1.64	2.83e-01	1.00e+00	4POSTN, COL6A3, INHBA, FLNA	175
TATAAA_TATA_01	6.03e-04	3.37	1.64	1.14e-01	6.83e-01	13POSTN, COL1A1, COL1A2, FN1, SULF1, THBS2, ANGPTL4, SERPINE1, PLOD2, RCN3, EFEMP1, INHBA, TPM2	1317
YKACATTT_UNKNOWN	5.25e-03	4.87	1.50	2.83e-01	1.00e+00	5SULF1, THBS1, PLOD2, MICAL2, EFEMP1	290
AAANWWTGC_UNKNOWN	7.07e-03	5.69	1.47	3.64e-01	1.00e+00	4FN1, LOX, THBS2, INHBA	195
SRF_C	9.84e-03	5.15	1.33	4.13e-01	1.00e+00	4COL1A2, THBS1, TAGLN, FLNA	215
SRF_01	1.74e-02	10.62	1.22	4.84e-01	1.00e+00	2THBS1, FLNA	51
SMAD3_Q6	1.46e-02	4.57	1.18	4.59e-01	1.00e+00	4FAP, LOX, THBS2, S100A16	242
AP3_Q6	1.64e-02	4.40	1.14	4.84e-01	1.00e+00	4FN1, SULF1, SPARC, FSTL1	251
CEBPB_01	2.00e-02	4.13	1.07	4.84e-01	1.00e+00	4SULF1, FAP, ITGA5, TPM2	267
NKX25_02	2.00e-02	4.13	1.07	4.84e-01	1.00e+00	4SULF1, INHBA, TPM2, FLNA	267
UBN1_TARGET_GENES	2.78e-02	2.24	1.06	6.06e-01	1.00e+00	12LOX, COL3A1, TNFRSF11B, CCDC80, TNC, THBS1, NNMT, PLOD2, TPM2, VIM, PPIC, GPX8	1779
RYTTCCTG_ETS2_B	1.83e-02	2.49	1.06	4.84e-01	1.00e+00	9COL6A3, THBS2, CCDC80, TIMP1, SPARC, MICAL2, FSTL1, TPM2, KDELR3	1112

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GO Biological Processes:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GOBP_COLLAGEN_FIBRIL_ORGANIZATION	5.30e-13	60.82	24.52	1.98e-09	3.96e-09	9COL1A1, COL1A2, COL5A1, LOX, LOXL2, COL3A1, COL5A2, SERPINH1, EMILIN1	54
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION	7.35e-30	43.26	23.63	5.50e-26	5.50e-26	28POSTN, COL1A1, COL1A2, FN1, COL6A3, COL5A1, SULF1, FAP, LOX, LOXL2, COL3A1, SERPINE1, TNFRSF11B, CCDC80, COL6A2, CREB3L1, BGN, TNC, COL5A2, TIMP1, THBS1, SPARC, FBN1, COL6A1, SERPINH1, ITGA5, EMILIN1, ADAM12	396
GOBP_COLLAGEN_BIOSYNTHETIC_PROCESS	1.02e-09	46.09	16.60	9.27e-07	7.59e-06	7COL1A1, COL5A1, CREB3L1, SERPINH1, RCN3, VIM, EMILIN1	51
GOBP_ENDODERMAL_CELL_DIFFERENTIATION	1.81e-08	44.79	14.72	9.02e-06	1.35e-04	6FN1, COL5A1, COL5A2, COL6A1, ITGA5, INHBA	44
GOBP_PEPTIDYL_LYSINE_OXIDATION	1.54e-04	172.68	14.09	1.74e-02	1.00e+00	2LOX, LOXL2	5
GOBP_POST_EMBRYONIC_EYE_MORPHOGENESIS	1.54e-04	172.68	14.09	1.74e-02	1.00e+00	2FBN1, EFEMP1	5
GOBP_REGULATION_OF_ENDODERMAL_CELL_DIFFERENTIATION	1.54e-04	172.68	14.09	1.74e-02	1.00e+00	2COL5A1, COL5A2	5
GOBP_REGULATION_OF_FIBRINOLYSIS	2.09e-05	72.24	12.54	3.40e-03	1.57e-01	3FAP, SERPINE1, THBS1	14
GOBP_ENDODERM_FORMATION	5.70e-08	36.21	12.03	2.13e-05	4.27e-04	6FN1, COL5A1, COL5A2, COL6A1, ITGA5, INHBA	53
GOBP_NEGATIVE_REGULATION_OF_PLASMINOGEN_ACTIVATION	2.31e-04	129.66	11.45	2.40e-02	1.00e+00	2SERPINE1, THBS1	6
GOBP_COLLAGEN_METABOLIC_PROCESS	3.48e-10	27.40	11.41	5.20e-07	2.60e-06	9COL1A1, COL1A2, COL5A1, FAP, CREB3L1, SERPINH1, RCN3, VIM, EMILIN1	109
GOBP_POST_EMBRYONIC_ANIMAL_ORGAN_MORPHOGENESIS	3.22e-04	103.49	9.64	3.13e-02	1.00e+00	2FBN1, EFEMP1	7
GOBP_PEPTIDE_CROSS_LINKING	1.05e-05	34.98	8.63	1.88e-03	7.89e-02	4FN1, COL3A1, BGN, THBS1	35
GOBP_ENDODERM_DEVELOPMENT	5.02e-07	24.31	8.21	1.39e-04	3.75e-03	6FN1, COL5A1, COL5A2, COL6A1, ITGA5, INHBA	76
GOBP_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	1.13e-04	37.87	7.01	1.41e-02	8.45e-01	3SULF1, CREB3L1, THBS1	24
GOBP_FIBRINOLYSIS	1.28e-04	36.22	6.71	1.52e-02	9.57e-01	3FAP, SERPINE1, THBS1	25
GOBP_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION	6.39e-06	22.37	6.71	1.26e-03	4.78e-02	5POSTN, COL1A1, SERPINE1, THBS1, LGALS1	67
GOBP_REGULATION_OF_CELL_SUBSTRATE_ADHESION	9.70e-09	15.03	6.61	5.18e-06	7.26e-05	10POSTN, COL1A1, FN1, SERPINE1, CCDC80, THBS1, LGALS1, ITGA5, FLNA, EMILIN1	218
GOBP_ELASTIC_FIBER_ASSEMBLY	6.85e-04	64.86	6.55	5.61e-02	1.00e+00	2LOX, EMILIN1	10
GOBP_NEGATIVE_REGULATION_OF_FIBRINOLYSIS	6.85e-04	64.86	6.55	5.61e-02	1.00e+00	2SERPINE1, THBS1	10

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Immunological Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GSE28737_BCL6_HET_VS_BCL6_KO_FOLLICULAR_BCELL_DN	4.29e-09	16.45	7.22	2.09e-05	2.09e-05	10COL1A1, COL1A2, COL6A3, LOX, BGN, TNC, SPARC, SERPINH1, FSTL1, KDELR3	200
GSE4748_CTRL_VS_LPS_STIM_DC_3H_UP	6.91e-08	14.37	6.05	1.68e-04	3.36e-04	9POSTN, ANGPTL4, COL3A1, SERPINE1, CREB3L1, COL5A2, FBN1, FSTL1, INHBA	200
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP	5.89e-07	13.30	5.31	9.57e-04	2.87e-03	8ANGPTL4, TIMP1, TAGLN, S100A16, LTBP2, FSTL1, GPX8, ADAM12	187
GSE27434_WT_VS_DNMT1_KO_TREG_DN	9.73e-07	12.40	4.96	1.19e-03	4.74e-03	8COL1A2, SERPINE1, COL5A2, COL6A1, SERPINH1, INHBA, KDELR3, PPIC	200
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_DP_THYMOCYTES_UP	1.15e-05	10.60	3.97	6.43e-03	5.60e-02	7FN1, SERPINE1, KRT18, THBS1, SPARC, TAGLN, FSTL1	199
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP	1.19e-05	10.54	3.95	6.43e-03	5.79e-02	7COL1A2, COL6A3, SERPINE1, BGN, TIMP1, LTBP2, GPX8	200
GSE4748_CTRL_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_DN	1.19e-05	10.54	3.95	6.43e-03	5.79e-02	7COL6A3, SERPINE1, KRT18, COL6A2, SERPINH1, S100A16, INHBA	200
GSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_UP	1.19e-05	10.54	3.95	6.43e-03	5.79e-02	7COL3A1, COL5A2, TIMP1, COL6A1, RCN3, PPIC, ADAM12	200
GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	1.19e-05	10.54	3.95	6.43e-03	5.79e-02	7COL1A2, TNC, COL5A2, NNMT, FBN1, TAGLN, KDELR3	200
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_DP_THYMOCYTES_UP	1.17e-04	8.88	3.05	3.01e-02	5.71e-01	6FN1, THBS2, SERPINE1, KRT18, TAGLN, FSTL1	198
GSE1460_INTRATHYMIC_T_PROGENITOR_VS_THYMIC_STROMAL_CELL_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6COL6A2, CREB3L1, THBS1, ITGA5, VIM, EMILIN1	200
GSE17721_0.5H_VS_24H_CPG_BMDC_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6COL5A1, LOX, SERPINE1, FSTL1, ITGA5, VEGFC	200
GSE20715_0H_VS_24H_OZONE_TLR4_KO_LUNG_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6LOX, ANGPTL4, KRT18, TIMP1, THBS1, LTBP2	200
GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6FN1, LOXL2, TIMP1, RCN3, INHBA, TPM2	200
GSE37301_RAG2_KO_VS_RAG2_AND_ETS1_KO_NK_CELL_UP	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6COL1A1, CCDC80, COL6A2, NNMT, FBN1, COL6A1	200
GSE42021_CD24HI_TREG_VS_CD24HI_TCONV_THYMUS_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6FN1, SERPINE1, BGN, COL6A1, SERPINH1, PPIC	200
GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_60H_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6FN1, ANGPTL4, COL6A2, FBN1, S100A16, LTBP2	200
GSE43955_1H_VS_10H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6COL1A2, FN1, BGN, COL5A2, NNMT, LTBP2	200
GSE43955_10H_VS_60H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6COL1A1, COL1A2, THBS2, TNFRSF11B, TAGLN, INHBA	200
GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_UP	1.24e-04	8.78	3.02	3.01e-02	6.03e-01	6COL1A1, COL5A1, SPARC, COL6A1, SERPINH1, ADAM12	200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol	TF Rank	DNA Binding Domain	Motif Status	IUPAC PWM	GTEx	DepMap	Decartes
CREB3L1	19	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
FBN1	28	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
FLNA	44	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Go annotation is based on (PMID: 15684392), which shows that it binds FOXC1 and PBX1 but doesnt show evidence for binding to DNA
PRRX1	67	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
GREM1	69	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
MSC	70	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
SPHK1	71	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
AEBP1	72	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).
FHL2	113	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	LIM ZF proteins are unlikely to bind DNA. Experimental evidence does not support a role for FHL2 as a sequence-specific DNA-binding protein (PMID:10654935)
SNAI2	119	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
VGLL3	121	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 23380592) describes this protein as a co-activator, and it doesnt seem to have a DBD (fig. 1)
ENO1	131	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Enolase - DNA binding not shown to be direct
HMGA2	134	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	None	None
NFIX	152	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
MDFI	168	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	MDF1 is a co-repressor that inhibits DNA-binding (PMID: 8797820)
TNFSF4	169	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Extracellular signaling molecule. Included only because it regulates TFs.
GATA6	170	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
TGFB1I1	179	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Available evidence suggests that it acts as a co-factor
PPP1R13L	190	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
SIX5	205	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None

QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID	Singler label	Singler Delta	Activity Score	Top Singler Raw Scores
T230_ACTACGACAGGTGAGT-1	Tissue_stem_cells:BM_MSC	0.20	2519.83	Raw ScoresiPS_cells:adipose_stem_cells: 0.45, Fibroblasts:breast: 0.44, Tissue_stem_cells:BM_MSC: 0.44, iPS_cells:CRL2097_foreskin: 0.44, Smooth_muscle_cells:vascular:IL-17: 0.44, Smooth_muscle_cells:vascular: 0.43, Tissue_stem_cells:BM_MSC:BMP2: 0.43, MSC: 0.43, Osteoblasts:BMP2: 0.43, Fibroblasts:foreskin: 0.43
T162_GGGAGTACAATACCTG-1	Smooth_muscle_cells:vascular	0.21	1818.06	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.46, Tissue_stem_cells:BM_MSC: 0.45, Smooth_muscle_cells:vascular: 0.45, iPS_cells:adipose_stem_cells: 0.45, Fibroblasts:breast: 0.45, iPS_cells:CRL2097_foreskin: 0.44, Osteoblasts: 0.44, Osteoblasts:BMP2: 0.44, iPS_cells:foreskin_fibrobasts: 0.44, Tissue_stem_cells:BM_MSC:BMP2: 0.44
T230_TTCCTCTCAGCACGAA-1	iPS_cells:CRL2097_foreskin	0.19	1776.63	Raw ScoresiPS_cells:adipose_stem_cells: 0.42, Tissue_stem_cells:BM_MSC: 0.42, iPS_cells:CRL2097_foreskin: 0.41, Fibroblasts:breast: 0.41, Smooth_muscle_cells:vascular: 0.41, Smooth_muscle_cells:vascular:IL-17: 0.41, MSC: 0.4, Osteoblasts: 0.4, Tissue_stem_cells:BM_MSC:osteogenic: 0.4, Osteoblasts:BMP2: 0.4
T214_TATCCTAAGGGACCAT-1	Osteoblasts	0.19	1456.25	Raw ScoresiPS_cells:adipose_stem_cells: 0.41, Fibroblasts:breast: 0.4, Osteoblasts: 0.4, Smooth_muscle_cells:bronchial: 0.39, Smooth_muscle_cells:bronchial:vit_D: 0.39, iPS_cells:CRL2097_foreskin: 0.39, Smooth_muscle_cells:vascular: 0.39, iPS_cells:fibroblasts: 0.39, Osteoblasts:BMP2: 0.39, Tissue_stem_cells:BM_MSC:TGFb3: 0.39
T200_TATTCCATCGCATTAG-1	Tissue_stem_cells:BM_MSC:BMP2	0.18	1260.49	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.42, iPS_cells:adipose_stem_cells: 0.42, Fibroblasts:foreskin: 0.42, Tissue_stem_cells:BM_MSC: 0.41, Tissue_stem_cells:BM_MSC:TGFb3: 0.41, Smooth_muscle_cells:vascular:IL-17: 0.41, Smooth_muscle_cells:vascular: 0.4, Fibroblasts:breast: 0.4, Osteoblasts: 0.4, Chondrocytes:MSC-derived: 0.4
T162_GATCACATCGCTAGCG-1	iPS_cells:adipose_stem_cells	0.18	898.31	Raw ScoresiPS_cells:adipose_stem_cells: 0.41, Fibroblasts:breast: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Tissue_stem_cells:BM_MSC:BMP2: 0.4, Smooth_muscle_cells:vascular:IL-17: 0.4, Smooth_muscle_cells:vascular: 0.4, MSC: 0.39, Tissue_stem_cells:BM_MSC:osteogenic: 0.39, Osteoblasts: 0.39, iPS_cells:CRL2097_foreskin: 0.39
T162_GGGATGATCTAGTCAG-1	Smooth_muscle_cells:vascular:IL-17	0.10	826.20	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.39, iPS_cells:adipose_stem_cells: 0.38, Smooth_muscle_cells:vascular:IL-17: 0.38, Fibroblasts:foreskin: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Smooth_muscle_cells:vascular: 0.37, Tissue_stem_cells:BM_MSC:osteogenic: 0.37, Chondrocytes:MSC-derived: 0.37, Fibroblasts:breast: 0.37
T214_TCCTAATTCACCTCGT-1	Osteoblasts	0.14	824.60	Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Fibroblasts:breast: 0.35, iPS_cells:CRL2097_foreskin: 0.34, Smooth_muscle_cells:bronchial:vit_D: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Smooth_muscle_cells:bronchial: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Smooth_muscle_cells:vascular: 0.34, Tissue_stem_cells:BM_MSC: 0.33, Osteoblasts: 0.33
T162_GAGTTACTCCATGCAA-1	Smooth_muscle_cells:vascular	0.18	804.51	Raw ScoresFibroblasts:foreskin: 0.45, MSC: 0.45, iPS_cells:foreskin_fibrobasts: 0.44, iPS_cells:skin_fibroblast: 0.44, iPS_cells:CRL2097_foreskin: 0.44, Tissue_stem_cells:BM_MSC: 0.44, Smooth_muscle_cells:vascular: 0.44, Smooth_muscle_cells:vascular:IL-17: 0.44, iPS_cells:PDB_fibroblasts: 0.44, iPS_cells:adipose_stem_cells: 0.44
T214_TTACGTTCACTCCCTA-1	Tissue_stem_cells:BM_MSC:TGFb3	0.18	770.52	Raw ScoresiPS_cells:adipose_stem_cells: 0.42, Smooth_muscle_cells:bronchial: 0.42, Tissue_stem_cells:BM_MSC:BMP2: 0.42, Fibroblasts:breast: 0.42, Osteoblasts: 0.42, Smooth_muscle_cells:bronchial:vit_D: 0.42, Tissue_stem_cells:BM_MSC:TGFb3: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Smooth_muscle_cells:vascular: 0.41, Chondrocytes:MSC-derived: 0.41
T162_ATTCGTTGTAACTTCG-1	Smooth_muscle_cells:vascular	0.18	753.34	Raw ScoresMSC: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Fibroblasts:foreskin: 0.4, Fibroblasts:breast: 0.4, Smooth_muscle_cells:vascular: 0.39, iPS_cells:skin_fibroblast: 0.39, iPS_cells:foreskin_fibrobasts: 0.39, Smooth_muscle_cells:vascular:IL-17: 0.39, iPS_cells:adipose_stem_cells: 0.39, iPS_cells:CRL2097_foreskin: 0.39
T214_GAGGCAAGTCGATTAC-1	iPS_cells:adipose_stem_cells	0.19	727.48	Raw ScoresiPS_cells:adipose_stem_cells: 0.39, Fibroblasts:breast: 0.39, Osteoblasts: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Smooth_muscle_cells:vascular: 0.38, iPS_cells:CRL2097_foreskin: 0.38, Osteoblasts:BMP2: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Smooth_muscle_cells:bronchial: 0.38
T162_CAGGCCATCAAATGCC-1	Smooth_muscle_cells:vascular	0.17	523.92	Raw ScoresiPS_cells:adipose_stem_cells: 0.4, Tissue_stem_cells:BM_MSC: 0.4, MSC: 0.4, Fibroblasts:breast: 0.4, Tissue_stem_cells:BM_MSC:BMP2: 0.39, Smooth_muscle_cells:vascular:IL-17: 0.39, iPS_cells:foreskin_fibrobasts: 0.39, iPS_cells:CRL2097_foreskin: 0.39, Smooth_muscle_cells:vascular: 0.39, iPS_cells:skin_fibroblast: 0.39
T162_GAGTCATTCGGCAGTC-1	Smooth_muscle_cells:vascular	0.17	510.52	Raw ScoresMSC: 0.45, Smooth_muscle_cells:vascular: 0.44, Fibroblasts:foreskin: 0.44, Tissue_stem_cells:lipoma-derived_MSC: 0.43, iPS_cells:skin_fibroblast: 0.43, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.43, iPS_cells:PDB_fibroblasts: 0.43, Neurons:Schwann_cell: 0.42, iPS_cells:foreskin_fibrobasts: 0.42, iPS_cells:fibroblasts: 0.42
T162_AATTTCCCATCGTGGC-1	Tissue_stem_cells:BM_MSC	0.16	506.61	Raw ScoresMSC: 0.45, Fibroblasts:foreskin: 0.45, iPS_cells:skin_fibroblast: 0.45, Smooth_muscle_cells:vascular: 0.45, iPS_cells:PDB_fibroblasts: 0.44, iPS_cells:foreskin_fibrobasts: 0.44, Tissue_stem_cells:lipoma-derived_MSC: 0.44, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.43, iPS_cells:CRL2097_foreskin: 0.43, Tissue_stem_cells:BM_MSC: 0.43
T162_CCGCAAGGTGTAGGAC-1	Smooth_muscle_cells:vascular	0.17	495.51	Raw ScoresMSC: 0.44, Fibroblasts:foreskin: 0.44, iPS_cells:skin_fibroblast: 0.43, Smooth_muscle_cells:vascular: 0.43, iPS_cells:PDB_fibroblasts: 0.43, Tissue_stem_cells:lipoma-derived_MSC: 0.43, iPS_cells:foreskin_fibrobasts: 0.43, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.43, Smooth_muscle_cells:umbilical_vein: 0.42, Tissue_stem_cells:BM_MSC: 0.42
T69_GGTGTTAAGTAGGCCA.1	Tissue_stem_cells:BM_MSC:BMP2	0.15	493.89	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC: 0.34, Smooth_muscle_cells:vascular:IL-17: 0.34, iPS_cells:adipose_stem_cells: 0.34, MSC: 0.33, Fibroblasts:breast: 0.33, Smooth_muscle_cells:vascular: 0.33, Chondrocytes:MSC-derived: 0.32, iPS_cells:CRL2097_foreskin: 0.32
T214_CCCTCAATCACCTCGT-1	Tissue_stem_cells:BM_MSC:BMP2	0.12	483.96	Raw ScoresiPS_cells:adipose_stem_cells: 0.36, iPS_cells:CRL2097_foreskin: 0.35, Fibroblasts:foreskin: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Fibroblasts:breast: 0.35, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.35, iPS_cells:fibroblasts: 0.35, MSC: 0.35, Smooth_muscle_cells:bronchial: 0.35, iPS_cells:foreskin_fibrobasts: 0.35
T162_AAAGTGAGTTAGAGTA-1	Fibroblasts:foreskin	0.15	469.20	Raw ScoresFibroblasts:foreskin: 0.41, MSC: 0.41, iPS_cells:foreskin_fibrobasts: 0.41, Tissue_stem_cells:lipoma-derived_MSC: 0.4, iPS_cells:PDB_fibroblasts: 0.4, iPS_cells:skin_fibroblast: 0.4, Smooth_muscle_cells:vascular: 0.4, iPS_cells:CRL2097_foreskin: 0.4, Neurons:Schwann_cell: 0.4, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.4
T162_ATTCTACCATCTAGAC-1	Tissue_stem_cells:BM_MSC	0.17	465.48	Raw ScoresFibroblasts:foreskin: 0.45, iPS_cells:foreskin_fibrobasts: 0.45, MSC: 0.45, iPS_cells:skin_fibroblast: 0.44, iPS_cells:adipose_stem_cells: 0.44, Tissue_stem_cells:BM_MSC: 0.44, iPS_cells:CRL2097_foreskin: 0.44, iPS_cells:PDB_fibroblasts: 0.44, Smooth_muscle_cells:vascular: 0.44, Smooth_muscle_cells:vascular:IL-17: 0.44
T214_TGCTGAATCTGCAGCG-1	iPS_cells:adipose_stem_cells	0.17	444.33	Raw ScoresiPS_cells:adipose_stem_cells: 0.32, Osteoblasts: 0.31, Fibroblasts:breast: 0.31, Tissue_stem_cells:BM_MSC:BMP2: 0.31, Tissue_stem_cells:BM_MSC:TGFb3: 0.31, iPS_cells:CRL2097_foreskin: 0.31, Tissue_stem_cells:BM_MSC: 0.31, Smooth_muscle_cells:bronchial: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.3, Chondrocytes:MSC-derived: 0.3
T69_ACATACGGTGACCAAG.1	Smooth_muscle_cells:vascular:IL-17	0.14	442.68	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Smooth_muscle_cells:vascular: 0.36, Fibroblasts:breast: 0.36, Tissue_stem_cells:BM_MSC: 0.35, iPS_cells:adipose_stem_cells: 0.35, Chondrocytes:MSC-derived: 0.35, Osteoblasts: 0.35, Smooth_muscle_cells:bronchial:vit_D: 0.34
T162_AGGGCTCCAAATCCCA-1	Smooth_muscle_cells:vascular	0.15	439.49	Raw ScoresFibroblasts:breast: 0.36, iPS_cells:adipose_stem_cells: 0.36, MSC: 0.36, Fibroblasts:foreskin: 0.36, iPS_cells:CRL2097_foreskin: 0.35, Smooth_muscle_cells:vascular:IL-17: 0.35, Tissue_stem_cells:BM_MSC: 0.35, iPS_cells:foreskin_fibrobasts: 0.35, Smooth_muscle_cells:vascular: 0.35, iPS_cells:skin_fibroblast: 0.35
T162_CAAGCTAAGGTCTGGA-1	Smooth_muscle_cells:vascular:IL-17	0.17	431.61	Raw ScoresTissue_stem_cells:BM_MSC: 0.4, iPS_cells:adipose_stem_cells: 0.4, Fibroblasts:foreskin: 0.39, Smooth_muscle_cells:vascular:IL-17: 0.39, MSC: 0.39, iPS_cells:CRL2097_foreskin: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39, iPS_cells:PDB_fibroblasts: 0.39, Fibroblasts:breast: 0.39, iPS_cells:foreskin_fibrobasts: 0.39
T162_TGTTGAGGTCGCCTAG-1	Tissue_stem_cells:BM_MSC:osteogenic	0.15	413.08	Raw ScoresTissue_stem_cells:BM_MSC: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39, iPS_cells:adipose_stem_cells: 0.39, Fibroblasts:foreskin: 0.38, Fibroblasts:breast: 0.38, Tissue_stem_cells:BM_MSC:osteogenic: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Smooth_muscle_cells:vascular: 0.38, iPS_cells:PDB_fibroblasts: 0.38
T162_TTACGTTAGGTCACTT-1	iPS_cells:adipose_stem_cells	0.16	395.96	Raw ScoresTissue_stem_cells:BM_MSC: 0.33, iPS_cells:adipose_stem_cells: 0.33, iPS_cells:CRL2097_foreskin: 0.32, Tissue_stem_cells:BM_MSC:osteogenic: 0.32, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Fibroblasts:breast: 0.32, Fibroblasts:foreskin: 0.32, Osteoblasts: 0.32, Smooth_muscle_cells:vascular: 0.32, iPS_cells:foreskin_fibrobasts: 0.32
T230_ACTATGGCACGGTGAA-1	iPS_cells:adipose_stem_cells	0.18	390.32	Raw ScoresiPS_cells:adipose_stem_cells: 0.42, MSC: 0.42, Tissue_stem_cells:BM_MSC: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Fibroblasts:foreskin: 0.41, Smooth_muscle_cells:vascular: 0.41, Fibroblasts:breast: 0.41, Neurons:Schwann_cell: 0.41, iPS_cells:foreskin_fibrobasts: 0.4, iPS_cells:PDB_fibroblasts: 0.4
T162_TGTCAGATCAACACGT-1	Tissue_stem_cells:BM_MSC	0.15	387.96	Raw ScoresFibroblasts:foreskin: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Smooth_muscle_cells:vascular:IL-17: 0.37, Smooth_muscle_cells:vascular: 0.37, Fibroblasts:breast: 0.37, iPS_cells:adipose_stem_cells: 0.37, iPS_cells:PDB_fibroblasts: 0.37, iPS_cells:skin_fibroblast: 0.37, iPS_cells:CRL2097_foreskin: 0.37
T162_GAGAAATCAGGTCAAG-1	Tissue_stem_cells:BM_MSC	0.18	381.02	Raw ScoresMSC: 0.45, Fibroblasts:foreskin: 0.45, iPS_cells:foreskin_fibrobasts: 0.44, Smooth_muscle_cells:vascular: 0.44, iPS_cells:CRL2097_foreskin: 0.44, Tissue_stem_cells:BM_MSC: 0.44, iPS_cells:skin_fibroblast: 0.44, iPS_cells:adipose_stem_cells: 0.43, Fibroblasts:breast: 0.43, iPS_cells:PDB_fibroblasts: 0.43
T214_ACTACGAGTACGTGTT-1	Tissue_stem_cells:BM_MSC	0.12	369.61	Raw ScoresiPS_cells:adipose_stem_cells: 0.33, Tissue_stem_cells:BM_MSC: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.33, Osteoblasts: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, Tissue_stem_cells:BM_MSC:osteogenic: 0.32, Fibroblasts:breast: 0.32, Chondrocytes:MSC-derived: 0.32, Tissue_stem_cells:iliac_MSC: 0.32, Smooth_muscle_cells:vascular: 0.32
T200_CTGTATTTCTCTCTTC-1	Tissue_stem_cells:BM_MSC:BMP2	0.17	343.51	Raw ScoresSmooth_muscle_cells:bronchial: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Smooth_muscle_cells:bronchial:vit_D: 0.36, Osteoblasts: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Chondrocytes:MSC-derived: 0.36, iPS_cells:CRL2097_foreskin: 0.36, iPS_cells:adipose_stem_cells: 0.36, Fibroblasts:breast: 0.36, Osteoblasts:BMP2: 0.35
T162_TTGACCCGTCACTACA-1	MSC	0.18	329.75	Raw ScoresMSC: 0.4, Fibroblasts:foreskin: 0.38, iPS_cells:skin_fibroblast: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, Tissue_stem_cells:lipoma-derived_MSC: 0.38, iPS_cells:CRL2097_foreskin: 0.38, Smooth_muscle_cells:umbilical_vein: 0.38, Smooth_muscle_cells:vascular: 0.38, Fibroblasts:breast: 0.38, iPS_cells:PDB_fibroblasts: 0.37
T162_GTATTGGTCCACGAAT-1	MSC	0.15	329.05	Raw ScoresMSC: 0.37, Smooth_muscle_cells:vascular: 0.36, Fibroblasts:foreskin: 0.36, Neurons:Schwann_cell: 0.36, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.36, Tissue_stem_cells:lipoma-derived_MSC: 0.36, iPS_cells:CRL2097_foreskin: 0.35, Smooth_muscle_cells:umbilical_vein: 0.35, iPS_cells:skin_fibroblast: 0.35, iPS_cells:PDB_fibroblasts: 0.35
T162_CAGCACGTCCACGTCT-1	MSC	0.17	327.86	Raw ScoresMSC: 0.42, Fibroblasts:foreskin: 0.41, Smooth_muscle_cells:vascular: 0.41, iPS_cells:foreskin_fibrobasts: 0.4, iPS_cells:skin_fibroblast: 0.4, iPS_cells:PDB_fibroblasts: 0.4, iPS_cells:CRL2097_foreskin: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Tissue_stem_cells:lipoma-derived_MSC: 0.4, Smooth_muscle_cells:umbilical_vein: 0.39
T162_TAACACGGTTCAAACC-1	iPS_cells:adipose_stem_cells	0.04	325.30	Raw ScoresDC:monocyte-derived:mature: 0.34, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.33, DC:monocyte-derived:LPS: 0.33, DC:monocyte-derived:AEC-conditioned: 0.33, Fibroblasts:foreskin: 0.33, Macrophage:monocyte-derived:S._aureus: 0.33, DC:monocyte-derived:antiCD40/VAF347: 0.33, DC:monocyte-derived:Poly(IC): 0.33, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.33
T200_CCCTGATAGAGAGCAA-1	Fibroblasts:breast	0.17	325.14	Raw ScoresFibroblasts:breast: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.36, iPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, iPS_cells:CRL2097_foreskin: 0.36, Osteoblasts: 0.35, Smooth_muscle_cells:bronchial: 0.35, MSC: 0.35, Chondrocytes:MSC-derived: 0.35, Tissue_stem_cells:BM_MSC: 0.35
T230_TGTTGAGGTCTACTGA-1	Smooth_muscle_cells:vascular	0.16	322.75	Raw ScoresMSC: 0.4, Smooth_muscle_cells:vascular: 0.4, Fibroblasts:foreskin: 0.39, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.39, Tissue_stem_cells:lipoma-derived_MSC: 0.39, Neurons:Schwann_cell: 0.39, Tissue_stem_cells:BM_MSC: 0.38, iPS_cells:skin_fibroblast: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, iPS_cells:PDB_fibroblasts: 0.38
T162_GCAGCTGCACTCCTTG-1	MSC	0.17	321.05	Raw ScoresMSC: 0.4, Smooth_muscle_cells:vascular: 0.39, Fibroblasts:foreskin: 0.39, iPS_cells:skin_fibroblast: 0.39, iPS_cells:foreskin_fibrobasts: 0.39, iPS_cells:CRL2097_foreskin: 0.38, Tissue_stem_cells:lipoma-derived_MSC: 0.38, iPS_cells:PDB_fibroblasts: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.38
T162_AGATGCTCACTGGCGT-1	Smooth_muscle_cells:vascular	0.15	320.73	Raw ScoresTissue_stem_cells:BM_MSC: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, iPS_cells:adipose_stem_cells: 0.35, Smooth_muscle_cells:vascular: 0.34, Smooth_muscle_cells:vascular:IL-17: 0.34, Fibroblasts:breast: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC:osteogenic: 0.34, MSC: 0.34, iPS_cells:foreskin_fibrobasts: 0.34
T162_CTCCAACTCGTTACCC-1	Fibroblasts:foreskin	0.17	314.48	Raw ScoresFibroblasts:foreskin: 0.42, MSC: 0.41, iPS_cells:skin_fibroblast: 0.41, iPS_cells:foreskin_fibrobasts: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Smooth_muscle_cells:vascular: 0.4, iPS_cells:PDB_fibroblasts: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Tissue_stem_cells:lipoma-derived_MSC: 0.4, iPS_cells:fibroblasts: 0.4
T162_TCATCATTCGGTGAAG-1	Smooth_muscle_cells:vascular	0.14	311.63	Raw ScoresTissue_stem_cells:BM_MSC: 0.39, Fibroblasts:foreskin: 0.39, MSC: 0.39, iPS_cells:skin_fibroblast: 0.39, iPS_cells:foreskin_fibrobasts: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, iPS_cells:adipose_stem_cells: 0.38, Fibroblasts:breast: 0.38, iPS_cells:CRL2097_foreskin: 0.38, iPS_cells:PDB_fibroblasts: 0.38
T162_GTCAGCGGTGCGGCTT-1	Smooth_muscle_cells:vascular	0.15	299.77	Raw ScoresSmooth_muscle_cells:vascular: 0.4, MSC: 0.4, Smooth_muscle_cells:vascular:IL-17: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Fibroblasts:foreskin: 0.39, iPS_cells:adipose_stem_cells: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39, iPS_cells:foreskin_fibrobasts: 0.39, iPS_cells:skin_fibroblast: 0.39, Fibroblasts:breast: 0.39
T200_ATAGACCGTACGCTTA-1	Fibroblasts:foreskin	0.14	297.94	Raw ScoresMSC: 0.4, Fibroblasts:foreskin: 0.4, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.39, Smooth_muscle_cells:vascular: 0.39, Neurons:Schwann_cell: 0.39, Tissue_stem_cells:lipoma-derived_MSC: 0.39, Endothelial_cells:HUVEC:PR8-infected: 0.39, iPS_cells:skin_fibroblast: 0.39, iPS_cells:fibroblasts: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39
T214_GCACATAGTAGCACGA-1	Tissue_stem_cells:BM_MSC:BMP2	0.14	295.49	Raw ScoresiPS_cells:adipose_stem_cells: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Fibroblasts:breast: 0.34, Smooth_muscle_cells:bronchial: 0.33, iPS_cells:CRL2097_foreskin: 0.33, Osteoblasts: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, Smooth_muscle_cells:vascular: 0.33, Smooth_muscle_cells:bronchial:vit_D: 0.33, Tissue_stem_cells:iliac_MSC: 0.33
T162_CTAACCCCAGCTTCCT-1	Fibroblasts:foreskin	0.16	287.82	Raw ScoresiPS_cells:foreskin_fibrobasts: 0.41, Fibroblasts:foreskin: 0.41, iPS_cells:CRL2097_foreskin: 0.41, iPS_cells:skin_fibroblast: 0.4, MSC: 0.4, iPS_cells:adipose_stem_cells: 0.4, iPS_cells:PDB_fibroblasts: 0.4, Fibroblasts:breast: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Smooth_muscle_cells:vascular: 0.39
T200_AGACACTAGGCCGCTT-1	Neurons:Schwann_cell	0.20	275.53	Raw ScoresNeurons:Schwann_cell: 0.42, Fibroblasts:foreskin: 0.39, iPS_cells:skin_fibroblast: 0.39, MSC: 0.39, iPS_cells:CRL2097_foreskin: 0.39, iPS_cells:PDB_fibroblasts: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Osteoblasts: 0.38
T162_CAACCAAGTGGATTTC-1	Smooth_muscle_cells:vascular	0.17	254.33	Raw ScoresiPS_cells:adipose_stem_cells: 0.38, iPS_cells:CRL2097_foreskin: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Fibroblasts:foreskin: 0.38, MSC: 0.38, Fibroblasts:breast: 0.38, Smooth_muscle_cells:vascular:IL-17: 0.38, Smooth_muscle_cells:vascular: 0.38, iPS_cells:PDB_fibroblasts: 0.38, iPS_cells:skin_fibroblast: 0.38
T162_TCAGCCTGTTCCACGG-1	MSC	0.16	251.05	Raw ScoresMSC: 0.4, Tissue_stem_cells:lipoma-derived_MSC: 0.38, Smooth_muscle_cells:umbilical_vein: 0.38, Fibroblasts:foreskin: 0.38, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.38, Tissue_stem_cells:dental_pulp: 0.38, iPS_cells:foreskin_fibrobasts: 0.37, Neurons:Schwann_cell: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Smooth_muscle_cells:vascular: 0.37
T69_GGCAATTTCGTTACGA.1	Smooth_muscle_cells:vascular:IL-17	0.17	248.68	Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.34, Smooth_muscle_cells:vascular: 0.33, Fibroblasts:breast: 0.33, Tissue_stem_cells:BM_MSC: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.32, iPS_cells:adipose_stem_cells: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, Chondrocytes:MSC-derived: 0.32, Fibroblasts:foreskin: 0.31, Tissue_stem_cells:BM_MSC:osteogenic: 0.31
T162_TCTGCCACATGGCACC-1	Smooth_muscle_cells:vascular	0.15	248.45	Raw ScoresFibroblasts:foreskin: 0.37, MSC: 0.37, iPS_cells:skin_fibroblast: 0.36, Tissue_stem_cells:BM_MSC: 0.36, iPS_cells:foreskin_fibrobasts: 0.36, Smooth_muscle_cells:vascular: 0.36, iPS_cells:PDB_fibroblasts: 0.36, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.36, iPS_cells:CRL2097_foreskin: 0.36, Tissue_stem_cells:lipoma-derived_MSC: 0.36

Below shows the significant enrichments of this GEP for literature curated gene lists
This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.36e-15
Mean rank of genes in gene set: 2193
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
FN1	0.0194227	4	GTEx	DepMap	Descartes	21.78	512.24
COL5A1	0.0179003	6	GTEx	DepMap	Descartes	2.72	75.23
THBS2	0.0164673	10	GTEx	DepMap	Descartes	2.02	90.75
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
BGN	0.0120244	20	GTEx	DepMap	Descartes	7.99	756.33
TNC	0.0116712	21	GTEx	DepMap	Descartes	2.52	55.91
COL5A2	0.0116344	22	GTEx	DepMap	Descartes	3.14	93.69
THBS1	0.0110827	24	GTEx	DepMap	Descartes	3.06	73.78
TAGLN	0.0092982	32	GTEx	DepMap	Descartes	23.97	1108.52
TPM2	0.0077177	42	GTEx	DepMap	Descartes	11.38	1297.18
COL12A1	0.0064047	58	GTEx	DepMap	Descartes	1.31	19.46
TPM1	0.0059039	63	GTEx	DepMap	Descartes	11.12	498.82
VCAN	0.0051682	75	GTEx	DepMap	Descartes	2.77	49.22
COL4A1	0.0048199	85	GTEx	DepMap	Descartes	11.11	293.20
MMP11	0.0039344	110	GTEx	DepMap	Descartes	0.82	57.41
COL15A1	0.0030649	162	GTEx	DepMap	Descartes	1.25	46.56
THY1	0.0026484	201	GTEx	DepMap	Descartes	7.51	319.59
VEGFA	0.0025638	207	GTEx	DepMap	Descartes	0.62	12.33
ACTA2	0.0016972	334	GTEx	DepMap	Descartes	14.32	1426.99
TMEM119	0.0016281	350	GTEx	DepMap	Descartes	0.20	19.27
MYL9	0.0015767	363	GTEx	DepMap	Descartes	7.36	453.63
TGFB1	0.0014679	393	GTEx	DepMap	Descartes	1.22	93.84
MYLK	0.0014343	401	GTEx	DepMap	Descartes	1.81	30.27
MMP2	0.0014263	404	GTEx	DepMap	Descartes	1.27	87.29
CNN2	0.0013739	429	GTEx	DepMap	Descartes	0.76	60.29
CNN3	0.0012696	467	GTEx	DepMap	Descartes	3.53	332.14
COL11A1	0.0012470	478	GTEx	DepMap	Descartes	0.25	7.50
TGFB2	0.0010723	564	GTEx	DepMap	Descartes	0.24	6.15
COL13A1	0.0007352	831	GTEx	DepMap	Descartes	0.04	2.25
TGFBR1	0.0005585	1048	GTEx	DepMap	Descartes	0.24	6.90
TGFBR2	0.0005047	1155	GTEx	DepMap	Descartes	0.85	29.64
LUM	0.0004614	1239	GTEx	DepMap	Descartes	4.61	490.99
IGFBP7	0.0004109	1373	GTEx	DepMap	Descartes	54.32	7379.00
COL8A1	0.0003673	1532	GTEx	DepMap	Descartes	1.51	44.78
COL14A1	0.0002021	2334	GTEx	DepMap	Descartes	0.50	13.07
WNT5A	0.0001947	2391	GTEx	DepMap	Descartes	0.07	1.84
HOPX	0.0000615	3817	GTEx	DepMap	Descartes	0.23	16.66
DCN	0.0000279	4347	GTEx	DepMap	Descartes	5.62	181.84
COL10A1	-0.0000133	5281	GTEx	DepMap	Descartes	0.00	0.00
IGFBP3	-0.0000690	6959	GTEx	DepMap	Descartes	0.98	54.41
ITGA7	-0.0000796	7284	GTEx	DepMap	Descartes	0.24	9.48
PGF	-0.0007067	12458	GTEx	DepMap	Descartes	1.21	66.84
MEF2C	-0.0007400	12475	GTEx	DepMap	Descartes	1.09	28.90
RGS5	-0.0008510	12505	GTEx	DepMap	Descartes	5.03	179.78
MYH11	-0.0012549	12535	GTEx	DepMap	Descartes	0.45	7.02
ACTG2	-0.0026012	12549	GTEx	DepMap	Descartes	2.14	108.33

Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.43e-08
Mean rank of genes in gene set: 701.23
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
COL6A2	0.0124972	18	GTEx	DepMap	Descartes	10.27	656.45
BGN	0.0120244	20	GTEx	DepMap	Descartes	7.99	756.33
SPARC	0.0108130	27	GTEx	DepMap	Descartes	26.81	1596.61
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
CALD1	0.0043513	96	GTEx	DepMap	Descartes	16.09	546.13
MGP	0.0007771	794	GTEx	DepMap	Descartes	14.30	2016.04
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41
LUM	0.0004614	1239	GTEx	DepMap	Descartes	4.61	490.99
LEPR	0.0004435	1278	GTEx	DepMap	Descartes	0.13	3.64
DCN	0.0000279	4347	GTEx	DepMap	Descartes	5.62	181.84

Bridge region mesencchymal (Olsen)
Marker genes shown in Fig. 3A of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - Cells were ordered by pseudotime in the bridge region, this first group of cells were from the mesenchymal part of the trajectory.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.64e-05
Mean rank of genes in gene set: 2104.92
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
BGN	0.0120244	20	GTEx	DepMap	Descartes	7.99	756.33
FGF1	0.0064599	56	GTEx	DepMap	Descartes	0.22	15.52
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
CALD1	0.0043513	96	GTEx	DepMap	Descartes	16.09	546.13
PODXL	0.0006042	987	GTEx	DepMap	Descartes	0.51	14.57
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41
LUM	0.0004614	1239	GTEx	DepMap	Descartes	4.61	490.99
NPNT	0.0004187	1347	GTEx	DepMap	Descartes	0.11	3.11
KLF4	0.0001402	2879	GTEx	DepMap	Descartes	0.68	41.80
MAFF	0.0000344	4241	GTEx	DepMap	Descartes	0.56	29.83
MYC	-0.0000399	6075	GTEx	DepMap	Descartes	0.61	29.67
TNNT2	-0.0001445	9142	GTEx	DepMap	Descartes	0.00	0.00

Stroma (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Stroma cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.19e-04
Mean rank of genes in gene set: 321.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FN1	0.0194227	4	GTEx	DepMap	Descartes	21.78	512.24
COL5A1	0.0179003	6	GTEx	DepMap	Descartes	2.72	75.23
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
COL6A1	0.0105974	29	GTEx	DepMap	Descartes	7.15	347.83
GPC3	0.0003579	1555	GTEx	DepMap	Descartes	0.39	34.93

Mesenchymal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.78e-04
Mean rank of genes in gene set: 22.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
COL6A1	0.0105974	29	GTEx	DepMap	Descartes	7.15	347.83
VIM	0.0070253	45	GTEx	DepMap	Descartes	62.85	4335.51

EMT II (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in HNSCC cell lines:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.45e-04
Mean rank of genes in gene set: 128.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FN1	0.0194227	4	GTEx	DepMap	Descartes	21.78	512.24
COL5A1	0.0179003	6	GTEx	DepMap	Descartes	2.72	75.23
VIM	0.0070253	45	GTEx	DepMap	Descartes	62.85	4335.51
AXL	0.0012899	458	GTEx	DepMap	Descartes	0.84	34.80

Subepicardial mesenchyme (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.70e-04
Mean rank of genes in gene set: 1746.71
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
TWIST2	0.0016742	336	GTEx	DepMap	Descartes	0.24	34.55
TBX18	0.0004155	1358	GTEx	DepMap	Descartes	0.15	5.95
TWIST1	-0.0002069	10448	GTEx	DepMap	Descartes	0.82	77.30

Mesenchymal cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that COL1A1+ Mesenchymal were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.50e-03
Mean rank of genes in gene set: 69
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
PDGFRB	0.0026324	202	GTEx	DepMap	Descartes	2.36	100.91

EMT I melanoma (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was melanoma specific.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.56e-03
Mean rank of genes in gene set: 91.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPM1	0.0059039	63	GTEx	DepMap	Descartes	11.12	498.82
CAV1	0.0046583	87	GTEx	DepMap	Descartes	4.86	257.05
RRAS	0.0037004	125	GTEx	DepMap	Descartes	2.00	394.98

Endothelial cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRB+ Endothelial cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.37e-03
Mean rank of genes in gene set: 608.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FLT1	0.0011407	525	GTEx	DepMap	Descartes	0.54	13.73
PTPRB	0.0010469	578	GTEx	DepMap	Descartes	0.30	3.63
EGFL7	0.0008594	723	GTEx	DepMap	Descartes	1.05	92.05

Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.60e-03
Mean rank of genes in gene set: 3466
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97
COL5A2	0.0116344	22	GTEx	DepMap	Descartes	3.14	93.69
FBN1	0.0107290	28	GTEx	DepMap	Descartes	1.39	27.74
FSTL1	0.0082558	38	GTEx	DepMap	Descartes	2.84	99.93
FBN2	0.0016735	338	GTEx	DepMap	Descartes	0.09	2.93
IGFBP5	0.0007223	845	GTEx	DepMap	Descartes	12.01	368.88
PENK	0.0002130	2250	GTEx	DepMap	Descartes	0.30	68.76
COL14A1	0.0002021	2334	GTEx	DepMap	Descartes	0.50	13.07
GSN	0.0001705	2578	GTEx	DepMap	Descartes	5.18	190.33
ITM2A	-0.0001233	8575	GTEx	DepMap	Descartes	0.07	13.76
SFRP1	-0.0004015	12099	GTEx	DepMap	Descartes	0.32	10.27
GAS1	-0.0007697	12484	GTEx	DepMap	Descartes	0.42	20.15

Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.79e-03
Mean rank of genes in gene set: 4342.16
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL33	0.0045716	89	GTEx	DepMap	Descartes	0.27	20.00
CXCL12	0.0032802	146	GTEx	DepMap	Descartes	1.26	92.21
IL1R1	0.0026709	196	GTEx	DepMap	Descartes	0.42	15.65
PDGFRB	0.0026324	202	GTEx	DepMap	Descartes	2.36	100.91
IGFBP6	0.0020312	279	GTEx	DepMap	Descartes	2.82	590.76
CCL2	0.0013310	441	GTEx	DepMap	Descartes	6.46	1348.00
LIF	0.0010854	554	GTEx	DepMap	Descartes	0.18	7.89
CFD	0.0010107	603	GTEx	DepMap	Descartes	0.24	59.94
SCARA3	0.0008540	724	GTEx	DepMap	Descartes	0.17	8.02
C7	0.0007499	820	GTEx	DepMap	Descartes	0.38	14.91
CXCL14	0.0007298	837	GTEx	DepMap	Descartes	0.36	47.50
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41
PDGFD	0.0004148	1360	GTEx	DepMap	Descartes	0.08	5.37
SCARA5	0.0002620	1966	GTEx	DepMap	Descartes	0.02	1.22
IGF1	0.0002582	1981	GTEx	DepMap	Descartes	0.59	17.96
HGF	0.0000897	3432	GTEx	DepMap	Descartes	0.33	7.85
SERPING1	-0.0000458	6254	GTEx	DepMap	Descartes	1.76	188.00
IL10	-0.0001141	8321	GTEx	DepMap	Descartes	0.03	2.09
RGMA	-0.0001318	8805	GTEx	DepMap	Descartes	0.09	2.03
CFB	-0.0002048	10404	GTEx	DepMap	Descartes	0.09	5.75
SOD2	-0.0002467	11063	GTEx	DepMap	Descartes	1.48	17.97
PDPN	-0.0003838	12032	GTEx	DepMap	Descartes	0.18	11.27
GPX3	-0.0004599	12241	GTEx	DepMap	Descartes	0.38	42.31
C3	-0.0004668	12256	GTEx	DepMap	Descartes	1.39	49.12
CXCL2	-0.0005218	12336	GTEx	DepMap	Descartes	2.22	311.41

Mesenchymal (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being expressed in a group of mesenchymal-like cells (some at least claimed to be neuroblastoma cells) shown in their UMAP representation on Fig. 1D. They reference the two Nature Genetics paper.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.01e-03
Mean rank of genes in gene set: 1726
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41
LEPR	0.0004435	1278	GTEx	DepMap	Descartes	0.13	3.64
DCN	0.0000279	4347	GTEx	DepMap	Descartes	5.62	181.84

SCPs neuroblastoma unique (Olsen)
Similar to above, but for genes unique to neuroblastoma SCP-like cells. Note FN1 is often used as a mesenchymal marker gene.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.49e-03
Mean rank of genes in gene set: 2806.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FN1	0.0194227	4	GTEx	DepMap	Descartes	21.78	512.24
TIMP3	0.0047671	86	GTEx	DepMap	Descartes	3.97	178.53
ANXA1	0.0010047	606	GTEx	DepMap	Descartes	4.93	450.99
IFITM3	0.0004060	1389	GTEx	DepMap	Descartes	16.42	4933.99
ITGB8	0.0001545	2730	GTEx	DepMap	Descartes	0.42	10.46
GFRA3	-0.0003817	12023	GTEx	DepMap	Descartes	0.20	20.67

Protein maturation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.88e-03
Mean rank of genes in gene set: 1400
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDIA3	0.0011427	523	GTEx	DepMap	Descartes	2.62	141.16
RPN2	0.0006382	940	GTEx	DepMap	Descartes	1.85	134.54
OS9	0.0001538	2737	GTEx	DepMap	Descartes	0.93	45.24

Endothelial Cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.85e-02
Mean rank of genes in gene set: 933.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ENG	0.0018244	305	GTEx	DepMap	Descartes	1.88	131.69
VWF	0.0003554	1562	GTEx	DepMap	Descartes	2.03	48.76

p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.15e-02
Mean rank of genes in gene set: 1090
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0025399	211	GTEx	DepMap	Descartes	8.12	77.81
CDKN1A	0.0002611	1969	GTEx	DepMap	Descartes	0.79	60.79

Mesencchymal populations mouse (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.74e-02
Mean rank of genes in gene set: 1355
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
FLI1	0.0001632	2643	GTEx	DepMap	Descartes	0.06	2.81

Stromal 1 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.97e-02
Mean rank of genes in gene set: 3694.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HMGA2	0.0035172	134	GTEx	DepMap	Descartes	0.07	2.12
MMP14	0.0024919	215	GTEx	DepMap	Descartes	0.79	56.17
COL27A1	0.0017353	324	GTEx	DepMap	Descartes	0.20	5.77
TGFB2	0.0010723	564	GTEx	DepMap	Descartes	0.24	6.15
CHD3	0.0000622	3806	GTEx	DepMap	Descartes	0.52	13.17
NFIB	-0.0001816	10016	GTEx	DepMap	Descartes	0.87	18.90
IGSF3	-0.0002286	10803	GTEx	DepMap	Descartes	0.13	2.69

Normal Schwann cell precurors, but not Neuroblastoma Scps (Olsen)
Based on their neuroblastoma data and stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-02
Mean rank of genes in gene set: 1
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97

Mixed phenotype identified at the fate split point mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells. markers are of the split point where SCPs differentiate.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-02
Mean rank of genes in gene set: 67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09

Inflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.35e-02
Mean rank of genes in gene set: 75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	0.0051682	75	GTEx	DepMap	Descartes	2.77	49.22

Mesenchymal (Kildisiute)
Mesenchymal markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.68e-02
Mean rank of genes in gene set: 202
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0026324	202	GTEx	DepMap	Descartes	2.36	100.91

Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.68e-02
Mean rank of genes in gene set: 3239
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPI1	0.0020840	266	GTEx	DepMap	Descartes	6.65	723.82
MIF	0.0012063	501	GTEx	DepMap	Descartes	4.26	865.80
TK1	0.0009933	618	GTEx	DepMap	Descartes	0.76	76.53
NPM1	-0.0003006	11571	GTEx	DepMap	Descartes	9.69	891.66

Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.27e-02
Mean rank of genes in gene set: 4964.15
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GJA1	0.0035483	132	GTEx	DepMap	Descartes	0.68	47.94
FBLN2	0.0034543	136	GTEx	DepMap	Descartes	0.56	29.02
CLIC4	0.0025184	214	GTEx	DepMap	Descartes	1.61	77.06
DUSP6	0.0011294	532	GTEx	DepMap	Descartes	0.91	55.41
TM4SF1	0.0007407	826	GTEx	DepMap	Descartes	1.63	103.67
LFNG	0.0002320	2137	GTEx	DepMap	Descartes	0.11	8.66
SPRY1	0.0002102	2269	GTEx	DepMap	Descartes	1.28	93.59
MECOM	0.0000849	3497	GTEx	DepMap	Descartes	0.10	3.44
JAG1	0.0000839	3518	GTEx	DepMap	Descartes	0.98	29.98
THBD	0.0000831	3530	GTEx	DepMap	Descartes	0.24	16.00
CDK1	0.0000558	3906	GTEx	DepMap	Descartes	0.36	22.04
FAM102A	0.0000288	4326	GTEx	DepMap	Descartes	0.14	4.55
SHROOM2	0.0000184	4533	GTEx	DepMap	Descartes	0.09	2.32
ADAMTS1	-0.0000687	6947	GTEx	DepMap	Descartes	0.81	25.88
IGFBP3	-0.0000690	6959	GTEx	DepMap	Descartes	0.98	54.41
HES1	-0.0001517	9352	GTEx	DepMap	Descartes	1.30	150.64
IVNS1ABP	-0.0002418	10984	GTEx	DepMap	Descartes	0.40	16.04
MCF2L	-0.0002542	11150	GTEx	DepMap	Descartes	0.04	0.85
RHOB	-0.0003382	11825	GTEx	DepMap	Descartes	3.40	276.31
MARCKSL1	-0.0008865	12510	GTEx	DepMap	Descartes	5.80	597.51

Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.49e-02
Mean rank of genes in gene set: 3531.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FLT1	0.0011407	525	GTEx	DepMap	Descartes	0.54	13.73
EGFL7	0.0008594	723	GTEx	DepMap	Descartes	1.05	92.05
PRCP	0.0001377	2900	GTEx	DepMap	Descartes	0.43	12.82
KDR	-0.0001803	9978	GTEx	DepMap	Descartes	0.22	5.48

Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.03e-02
Mean rank of genes in gene set: 3340
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A10	0.0039792	108	GTEx	DepMap	Descartes	14.78	4206.35
IFITM3	0.0004060	1389	GTEx	DepMap	Descartes	16.42	4933.99
B2M	-0.0001214	8523	GTEx	DepMap	Descartes	76.91	6472.56

Mesemchymal validated (Olsen)
Stated on pages 7 and 8 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is stated that a mesenchymal-like neuroblastoma cell state is validate by combined immunofluorescence staining for PDGFRA and FISH for PPMID gain, a gene on 17q.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.11e-02
Mean rank of genes in gene set: 1212
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41

Kidney Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-02
Mean rank of genes in gene set: 1628
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LYPD1	0.000338	1628	GTEx	DepMap	Descartes	0.59	27.44

EMT III (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in non-cycling cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.27e-01
Mean rank of genes in gene set: 4206.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2	0.0015422	370	GTEx	DepMap	Descartes	0.17	4.31
LAMB3	0.0005099	1147	GTEx	DepMap	Descartes	0.09	4.19
LAMA3	0.0000206	4498	GTEx	DepMap	Descartes	0.03	0.60
JUP	-0.0002294	10810	GTEx	DepMap	Descartes	0.33	18.84

Angioblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Angioblast subcluster of Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.52e-01
Mean rank of genes in gene set: 4126.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NES	0.0004178	1350	GTEx	DepMap	Descartes	2.45	75.19
MAP4K4	0.0001578	2692	GTEx	DepMap	Descartes	1.63	36.17
PREX1	-0.0001147	8338	GTEx	DepMap	Descartes	0.17	4.11

PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.57e-01
Mean rank of genes in gene set: 5362.62
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TGFB1	0.0014679	393	GTEx	DepMap	Descartes	1.22	93.84
ANXA1	0.0010047	606	GTEx	DepMap	Descartes	4.93	450.99
CSF1	0.0008305	743	GTEx	DepMap	Descartes	0.27	16.64
HIF1A	0.0004052	1392	GTEx	DepMap	Descartes	0.91	41.46
PTGS2	0.0003546	1567	GTEx	DepMap	Descartes	0.25	10.13
STAT6	0.0002008	2347	GTEx	DepMap	Descartes	0.22	13.10
TNFRSF10B	0.0001716	2569	GTEx	DepMap	Descartes	0.28	11.70
IRF1	0.0000430	4097	GTEx	DepMap	Descartes	0.88	32.18
ARG1	-0.0000079	5110	GTEx	DepMap	Descartes	0.00	0.00
STAT1	-0.0000695	6981	GTEx	DepMap	Descartes	1.99	89.75
STAT3	-0.0001396	9009	GTEx	DepMap	Descartes	1.31	46.08
IL1B	-0.0001416	9052	GTEx	DepMap	Descartes	0.64	57.04
SLC27A2	-0.0001484	9257	GTEx	DepMap	Descartes	0.03	0.66
ARG2	-0.0001748	9873	GTEx	DepMap	Descartes	0.13	6.31
CD84	-0.0001975	10283	GTEx	DepMap	Descartes	0.07	1.33
CD36	-0.0010835	12523	GTEx	DepMap	Descartes	0.84	15.96

Proteasomal degradation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this is for proteasomal degradataion:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.58e-01
Mean rank of genes in gene set: 4654
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PSME2	0.0004138	1364	GTEx	DepMap	Descartes	2.86	174.61
PSMA4	0.0001902	2429	GTEx	DepMap	Descartes	1.89	77.58
PSMA3	0.0001754	2536	GTEx	DepMap	Descartes	1.64	230.41
PSMB3	-0.0001051	8051	GTEx	DepMap	Descartes	2.09	448.40
PSMC2	-0.0001349	8890	GTEx	DepMap	Descartes	0.69	38.92

Stress response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.67e-01
Mean rank of genes in gene set: 4711.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SQSTM1	0.0006781	893	GTEx	DepMap	Descartes	1.95	140.01
ATF3	0.0006072	984	GTEx	DepMap	Descartes	2.38	224.12
GADD45B	-0.0000092	5164	GTEx	DepMap	Descartes	1.50	153.83
GADD45A	-0.0000104	5196	GTEx	DepMap	Descartes	0.83	104.12
DDIT3	-0.0002698	11322	GTEx	DepMap	Descartes	0.80	141.63

Myofibroblasts (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ACTA2+ Myofibroblasts were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.73e-01
Mean rank of genes in gene set: 4300.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TAGLN	0.0092982	32	GTEx	DepMap	Descartes	23.97	1108.52
ACTA2	0.0016972	334	GTEx	DepMap	Descartes	14.32	1426.99
MYH11	-0.0012549	12535	GTEx	DepMap	Descartes	0.45	7.02

M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.83e-01
Mean rank of genes in gene set: 5037.14
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VEGFA	0.0025638	207	GTEx	DepMap	Descartes	0.62	12.33
TGFB1	0.0014679	393	GTEx	DepMap	Descartes	1.22	93.84
ARG1	-0.0000079	5110	GTEx	DepMap	Descartes	0.00	0.00
IL13	-0.0000452	6234	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0000677	6914	GTEx	DepMap	Descartes	0.38	41.75
CD163	-0.0001063	8081	GTEx	DepMap	Descartes	0.08	2.02
IL10	-0.0001141	8321	GTEx	DepMap	Descartes	0.03	2.09

Stromal 3 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.94e-01
Mean rank of genes in gene set: 4471.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NOTCH3	0.0013193	446	GTEx	DepMap	Descartes	1.72	42.08
OLFML3	0.0009344	655	GTEx	DepMap	Descartes	0.99	118.51
PIK3R1	-0.0005003	12313	GTEx	DepMap	Descartes	0.67	15.34

Muscle progenitor (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PAX7+ Muscle progenitor were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.60e-01
Mean rank of genes in gene set: 4623
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDON	2.34e-05	4439	GTEx	DepMap	Descartes	0.07	1.04
PAX7	4.70e-06	4807	GTEx	DepMap	Descartes	0.00	0.00

Axon guidance (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for axon guidance instead of myelination:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.74e-01
Mean rank of genes in gene set: 4103
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SEMA3B	4.28e-05	4103	GTEx	DepMap	Descartes	0.91	56.74

Fetal Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Fetal Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.93e-01
Mean rank of genes in gene set: 4300
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRAMD1B	3.05e-05	4300	GTEx	DepMap	Descartes	0.09	1.94

Erythroid cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.44e-01
Mean rank of genes in gene set: 4822
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALAS2	4e-06	4822	GTEx	DepMap	Descartes	0	0

Hepatocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ALB+ Hepatocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D. The main text also speculated that these hepatocytes were probably derived from neighboring tissue, and hence artifactual, but there is no evidence presented for this.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.45e-01
Mean rank of genes in gene set: 5252
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALB	0.0003085	1754	GTEx	DepMap	Descartes	0.00	0.00
ASGR1	-0.0001298	8750	GTEx	DepMap	Descartes	0.08	5.61

Adrenal cortex (Kildisiute)
Adrenal cortex markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.85e-01
Mean rank of genes in gene set: 5216
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-1.12e-05	5216	GTEx	DepMap	Descartes	0.01	0.29

Adrenal gland cortex (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.85e-01
Mean rank of genes in gene set: 5216
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-1.12e-05	5216	GTEx	DepMap	Descartes	0.01	0.29

Immune (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Immune cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.29e-01
Mean rank of genes in gene set: 5817.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TMSB4X	0.0007294	838	GTEx	DepMap	Descartes	101.01	11015.74
LCP2	-0.0002283	10797	GTEx	DepMap	Descartes	0.12	3.54

Cell cycle (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.40e-01
Mean rank of genes in gene set: 5956.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PCNA	0.0001282	2989	GTEx	DepMap	Descartes	0.80	86.81
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

Schwann cell precursor Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454). These genes were used to show cells transitioning from a SCP to a symphathoblast state in their human fetal single-cell RNA-seq data.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.57e-01
Mean rank of genes in gene set: 6151
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97
NGFR	0.0003197	1704	GTEx	DepMap	Descartes	0.68	43.70
MOXD1	0.0001575	2694	GTEx	DepMap	Descartes	0.04	3.77
COL2A1	0.0001381	2898	GTEx	DepMap	Descartes	0.01	0.62
MBP	-0.0000176	5406	GTEx	DepMap	Descartes	0.20	3.97
GAS7	-0.0001171	8405	GTEx	DepMap	Descartes	0.59	14.61
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
S100B	-0.0001706	9776	GTEx	DepMap	Descartes	1.70	378.89
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17

M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.61e-01
Mean rank of genes in gene set: 6169.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL33	0.0045716	89	GTEx	DepMap	Descartes	0.27	20.00
CCL2	0.0013310	441	GTEx	DepMap	Descartes	6.46	1348.00
TLR4	0.0000544	3917	GTEx	DepMap	Descartes	0.10	2.02
CD80	0.0000277	4356	GTEx	DepMap	Descartes	0.03	1.83
CD14	-0.0000677	6914	GTEx	DepMap	Descartes	0.38	41.75
ITGAX	-0.0000816	7350	GTEx	DepMap	Descartes	0.03	1.70
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
TNF	-0.0001271	8670	GTEx	DepMap	Descartes	0.10	9.35
IL18	-0.0001375	8957	GTEx	DepMap	Descartes	0.18	20.27
IL1B	-0.0001416	9052	GTEx	DepMap	Descartes	0.64	57.04
CXCL16	-0.0001943	10234	GTEx	DepMap	Descartes	0.26	18.81

Pigmentation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, Skin pigmentation genes, identified in melanoma.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.11e-01
Mean rank of genes in gene set: 6323.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MITF	0.0000053	4793	GTEx	DepMap	Descartes	0.11	4.37
MLANA	-0.0000119	5243	GTEx	DepMap	Descartes	0.00	0.00
DCT	-0.0000294	5774	GTEx	DepMap	Descartes	0.00	0.00
PMEL	-0.0001576	9483	GTEx	DepMap	Descartes	0.00	0.00

M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.28e-01
Mean rank of genes in gene set: 6340.13
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VEGFA	0.0025638	207	GTEx	DepMap	Descartes	0.62	12.33
TGFB1	0.0014679	393	GTEx	DepMap	Descartes	1.22	93.84
HIF1A	0.0004052	1392	GTEx	DepMap	Descartes	0.91	41.46
TNFRSF10B	0.0001716	2569	GTEx	DepMap	Descartes	0.28	11.70
NOS2	0.0000138	4625	GTEx	DepMap	Descartes	0.01	0.50
ARG1	-0.0000079	5110	GTEx	DepMap	Descartes	0.00	0.00
CD274	-0.0000427	6161	GTEx	DepMap	Descartes	0.01	0.85
CD14	-0.0000677	6914	GTEx	DepMap	Descartes	0.38	41.75
IL10	-0.0001141	8321	GTEx	DepMap	Descartes	0.03	2.09
TNF	-0.0001271	8670	GTEx	DepMap	Descartes	0.10	9.35
STAT3	-0.0001396	9009	GTEx	DepMap	Descartes	1.31	46.08
IL1B	-0.0001416	9052	GTEx	DepMap	Descartes	0.64	57.04
ARG2	-0.0001748	9873	GTEx	DepMap	Descartes	0.13	6.31
CD84	-0.0001975	10283	GTEx	DepMap	Descartes	0.07	1.33
CD36	-0.0010835	12523	GTEx	DepMap	Descartes	0.84	15.96

Melanocytes (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.77e-01
Mean rank of genes in gene set: 6683.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MITF	0.0000053	4793	GTEx	DepMap	Descartes	0.11	4.37
DCT	-0.0000294	5774	GTEx	DepMap	Descartes	0.00	0.00
PMEL	-0.0001576	9483	GTEx	DepMap	Descartes	0.00	0.00

B cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.98e-01
Mean rank of genes in gene set: 7174
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-7.55e-05	7174	GTEx	DepMap	Descartes	0.05	7.87

Erythrocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that HBA2+ Erythrocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.05e-01
Mean rank of genes in gene set: 7239
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK1	-7.78e-05	7239	GTEx	DepMap	Descartes	0.04	0.47

Antigen Presenting CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain antigen presenting specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.20e-01
Mean rank of genes in gene set: 6594.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT18	0.0138213	16	GTEx	DepMap	Descartes	4.64	503.55
S100A13	0.0069114	46	GTEx	DepMap	Descartes	2.88	292.63
KRT8	0.0051287	76	GTEx	DepMap	Descartes	1.62	101.10
S100A10	0.0039792	108	GTEx	DepMap	Descartes	14.78	4206.35
S100A3	0.0006219	964	GTEx	DepMap	Descartes	0.23	59.58
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26
CD83	-0.0002169	10603	GTEx	DepMap	Descartes	0.69	44.63
KRT19	-0.0004644	12252	GTEx	DepMap	Descartes	1.16	105.82
S100A4	-0.0005266	12343	GTEx	DepMap	Descartes	6.83	1377.82
SLPI	-0.0013669	12537	GTEx	DepMap	Descartes	4.79	1267.37
UPK3B	-0.0018318	12545	GTEx	DepMap	Descartes	0.13	6.01

Myocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that MYH3+ Myocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.60e-01
Mean rank of genes in gene set: 7328
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYH3	-0.0000369	5992	GTEx	DepMap	Descartes	0.03	0.49
TTN	-0.0001268	8664	GTEx	DepMap	Descartes	0.01	0.02

Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.63e-01
Mean rank of genes in gene set: 7039
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
CDK1	0.0000558	3906	GTEx	DepMap	Descartes	0.36	22.04
UBE2C	-0.0001528	9369	GTEx	DepMap	Descartes	0.74	137.60
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.66e-01
Mean rank of genes in gene set: 7171.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRB	0.0010469	578	GTEx	DepMap	Descartes	0.30	3.63
KDR	-0.0001803	9978	GTEx	DepMap	Descartes	0.22	5.48
PLVAP	-0.0002394	10959	GTEx	DepMap	Descartes	0.76	53.67

Neuroblastoma SCPs but not normal SCPs (Olsen)
The same as above:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.66e-01
Mean rank of genes in gene set: 7376.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB8	0.0001545	2730	GTEx	DepMap	Descartes	0.42	10.46
GFRA3	-0.0003817	12023	GTEx	DepMap	Descartes	0.20	20.67

Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.20e-01
Mean rank of genes in gene set: 7768.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
EZH2	-0.0003845	12036	GTEx	DepMap	Descartes	0.22	8.73

SCPs mouse unique (Olsen)
Selected list of SCP marker genes shown in Fig. 2B of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these genes were unique to mouse SCPs as determined by the linearge tracing study Furlan et al. (Science 2017, PMID 28684471).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.35e-01
Mean rank of genes in gene set: 7414.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97
CRABP1	-0.0000471	6297	GTEx	DepMap	Descartes	0.08	6.83
SCRG1	-0.0002473	11071	GTEx	DepMap	Descartes	0.07	5.25
H1FX	-0.0004842	12289	GTEx	DepMap	Descartes	2.20	NA

Liver Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.40e-01
Mean rank of genes in gene set: 7919.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AHSG	-0.0000649	6833	GTEx	DepMap	Descartes	0.01	0.25
VTN	-0.0001394	9006	GTEx	DepMap	Descartes	0.06	8.65

Meta_8 undefined undifferentiated neuronal (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.42e-01
Mean rank of genes in gene set: 7940
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTNNB1	0.0000846	3507	GTEx	DepMap	Descartes	1.05	42.19
SOX11	-0.0005507	12373	GTEx	DepMap	Descartes	1.00	14.51

HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.60e-01
Mean rank of genes in gene set: 7754
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS10	0.0000315	4276	GTEx	DepMap	Descartes	0.84	154.33
CD163	-0.0001063	8081	GTEx	DepMap	Descartes	0.08	2.02
AIF1	-0.0002350	10905	GTEx	DepMap	Descartes	0.55	81.99

Bridge (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.80e-01
Mean rank of genes in gene set: 7890
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDH9	-0.0000225	5564	GTEx	DepMap	Descartes	0.00	0.00
ERBB4	-0.0001329	8840	GTEx	DepMap	Descartes	0.03	0.44
CTTNBP2	-0.0001487	9266	GTEx	DepMap	Descartes	0.00	0.00

Schwann cell Precursor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the SCP subcluster, which is part of the Adrenal Medulla cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.92e-01
Mean rank of genes in gene set: 7162.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LMO4	0.0006232	961	GTEx	DepMap	Descartes	1.34	48.98
NGFR	0.0003197	1704	GTEx	DepMap	Descartes	0.68	43.70
CST3	0.0002086	2279	GTEx	DepMap	Descartes	12.74	787.94
SERPINE2	0.0002071	2296	GTEx	DepMap	Descartes	0.86	32.04
CHL1	-0.0000046	5021	GTEx	DepMap	Descartes	0.20	4.26
DAGLA	-0.0001333	8845	GTEx	DepMap	Descartes	0.06	2.05
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
CNP	-0.0002418	10986	GTEx	DepMap	Descartes	0.63	24.71
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17
TTYH1	-0.0005603	12378	GTEx	DepMap	Descartes	0.34	14.06
PTPRZ1	-0.0008412	12504	GTEx	DepMap	Descartes	0.12	2.81

Cytotoxic T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.92e-01
Mean rank of genes in gene set: 9223
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23

Schwann cell precursors (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.15e-01
Mean rank of genes in gene set: 9519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13

Schwann cell precursors (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. The authors data suggest these SCPs can give rise to symphathoblasts, which can then give rise to chromaffin cells. However, these SCPs can also directly give rise to chromaffin cells (i.e there are two bridges/paths).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.15e-01
Mean rank of genes in gene set: 9519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13

Nerves and neurofiliment (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - NF200 is expressed in neurofiliments and is found close to SCPs in normal tissue, NRG1 is secreted by neurons, to which ERBB3 (on glia) binds.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.43e-01
Mean rank of genes in gene set: 9926
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	-0.0001778	9926	GTEx	DepMap	Descartes	0.03	0.26

EpiSen (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, an epithelial senescence associated program.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.48e-01
Mean rank of genes in gene set: 8139.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCN2	0.0000108	4678	GTEx	DepMap	Descartes	0.01	0.34
AQP3	-0.0000865	7514	GTEx	DepMap	Descartes	0.06	3.80
CLDN4	-0.0000972	7828	GTEx	DepMap	Descartes	0.03	1.12
SLPI	-0.0013669	12537	GTEx	DepMap	Descartes	4.79	1267.37

Myelination (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are state as being involved in Myelination and are expressed in the Schwann cell precursor cluster of their UMAP (Fig. 1D), these are suggested to represent more mature myelinating Schwann cells. MPZ is Myelin Protien Zero.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.70e-01
Mean rank of genes in gene set: 9154.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
LGI4	-0.0001581	9495	GTEx	DepMap	Descartes	0.24	23.13

Definitive Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Definitive Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.76e-01
Mean rank of genes in gene set: 8366.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHCHD10	0.0004630	1236	GTEx	DepMap	Descartes	2.30	355.25
CALN1	-0.0001423	9079	GTEx	DepMap	Descartes	0.01	0.09
GREB1	-0.0002344	10893	GTEx	DepMap	Descartes	0.05	0.79
CPE	-0.0004673	12257	GTEx	DepMap	Descartes	2.32	158.80

Noninflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.84e-01
Mean rank of genes in gene set: 9339
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD163	-0.0001063	8081	GTEx	DepMap	Descartes	0.08	2.02
MAF	-0.0002167	10597	GTEx	DepMap	Descartes	0.43	11.41

Chromaffin cells Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for chromaffin cells (differentiating from symphathoblasts):
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.91e-01
Mean rank of genes in gene set: 8852
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0002130	2250	GTEx	DepMap	Descartes	0.30	68.76
CHGB	-0.0003860	12040	GTEx	DepMap	Descartes	0.87	37.31
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29

Leukocyte (Kildisiute)
Leukocyes markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.94e-01
Mean rank of genes in gene set: 10787
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.0002277	10787	GTEx	DepMap	Descartes	0.14	4.68

Stress response (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.28e-01
Mean rank of genes in gene set: 9337
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
JUNB	-0.0000271	5712	GTEx	DepMap	Descartes	10.11	1018.77
FOS	-0.0001793	9960	GTEx	DepMap	Descartes	18.05	1660.12
JUN	-0.0005238	12339	GTEx	DepMap	Descartes	8.40	487.86

Bridge (Kildisiute)
Bridge cell (cites Furlan 2017) markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.29e-01
Mean rank of genes in gene set: 11603
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DLL3	-0.0003049	11603	GTEx	DepMap	Descartes	0.14	6.48

Immune cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRC+ Immune cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10104
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD247	-0.0001552	9421	GTEx	DepMap	Descartes	0.03	1.38
PTPRC	-0.0002277	10787	GTEx	DepMap	Descartes	0.14	4.68

Symphathoadrenal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.51e-01
Mean rank of genes in gene set: 12266
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29

Adrenergic neuroblatoma (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - neuroblastoma adrenergic markers derived from their data, which are state as resembling sympathoblasts and lacking chromffin markers such as PNMT:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 12330
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	-0.0005182	12330	GTEx	DepMap	Descartes	1.17	85.55

Adrenergic immature (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These is a marker listed for the immature adrenergic cells. SOX11 is referenced as important in early phases of pro-adrenergic differentiation (cites PMID 20147379) whereas SOX4 appears later. SOX11 is also associated with poor outcome in neuroblatoma bulk RNA-seq data (Olsen analysis).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 12373
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOX11	-0.0005507	12373	GTEx	DepMap	Descartes	1	14.51

Endothelium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 12546
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	-0.0020692	12546	GTEx	DepMap	Descartes	3.93	242.12

Pre-E Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Pre Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-01
Mean rank of genes in gene set: 8188.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LRP11	0.0002200	2208	GTEx	DepMap	Descartes	0.08	4.46
SLC31A1	0.0000600	3845	GTEx	DepMap	Descartes	0.16	6.23
ARHGEF28	0.0000162	4585	GTEx	DepMap	Descartes	0.11	NA
SLC38A4	0.0000125	4646	GTEx	DepMap	Descartes	0.00	0.00
TLE1	-0.0000231	5578	GTEx	DepMap	Descartes	0.30	15.94
ARNT2	-0.0001519	9358	GTEx	DepMap	Descartes	0.05	1.44
PCP4	-0.0002081	10464	GTEx	DepMap	Descartes	0.02	NA
RPS6KA6	-0.0002083	10471	GTEx	DepMap	Descartes	0.03	0.77
FAM163A	-0.0002252	10753	GTEx	DepMap	Descartes	0.03	1.48
NELFCD	-0.0003271	11758	GTEx	DepMap	Descartes	0.45	NA
TMX4	-0.0004667	12255	GTEx	DepMap	Descartes	0.59	14.82
JUN	-0.0005238	12339	GTEx	DepMap	Descartes	8.40	487.86

Schwann cell precursor (Kildisiute)
SCP markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.70e-01
Mean rank of genes in gene set: 10208.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17

Schwann cell precursors (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.70e-01
Mean rank of genes in gene set: 10208.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17

Immune cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 11336
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.0002277	10787	GTEx	DepMap	Descartes	0.14	4.68
CXCR4	-0.0003477	11885	GTEx	DepMap	Descartes	0.36	43.10

Other T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 9217.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-0.0000349	5935	GTEx	DepMap	Descartes	0.00	0.00
CCR7	-0.0001223	8544	GTEx	DepMap	Descartes	0.20	13.77
SELL	-0.0001485	9262	GTEx	DepMap	Descartes	0.04	3.07
LEF1	-0.0001899	10152	GTEx	DepMap	Descartes	0.13	9.07
TCF7	-0.0002097	10490	GTEx	DepMap	Descartes	0.14	5.20
CD4	-0.0002358	10921	GTEx	DepMap	Descartes	0.14	8.20

Schwann cell precursor (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being characteristic of Schwann cell lineage and Furlan et al. (Science 2017, PMID 28684471) is referenced to support this. These cell types seem to be claimed to form a bridge between the mesenchymal and adrenergic cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 10529.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
S100B	-0.0001706	9776	GTEx	DepMap	Descartes	1.70	378.89
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17

Schwann cell precursor-like Fig 1D (Olsen)
Similar to above, but for selected SCP marker genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 10529.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
S100B	-0.0001706	9776	GTEx	DepMap	Descartes	1.70	378.89
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17

Chromaffin cell-like (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 11956
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0003232	11719	GTEx	DepMap	Descartes	0.10	2.76
NPY	-0.0004373	12193	GTEx	DepMap	Descartes	4.39	614.25

Adrenergic mature (olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These markers are specific to the mature adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.88e-01
Mean rank of genes in gene set: 12024.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0003232	11719	GTEx	DepMap	Descartes	0.10	2.76
GAP43	-0.0005182	12330	GTEx	DepMap	Descartes	1.17	85.55

Meta_9 ATRX (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12195.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ATRX	-0.0003509	11906	GTEx	DepMap	Descartes	1.54	24.07
ZFHX3	-0.0007737	12485	GTEx	DepMap	Descartes	1.62	12.21

Adrenergic (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for adrenergic genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12196
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53

Neuroblastoma (Kildisiute)
Neuroblastoma markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12234.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYCN	-0.0003802	12017	GTEx	DepMap	Descartes	0.47	25.08
PHOX2A	-0.0007005	12452	GTEx	DepMap	Descartes	1.76	109.82

Chromaffin (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. These markers are expressed at a lower level in symphathoblasts.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12267.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53

Bridge region SCP-like (Olsen)
As above but for the SCP-like region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 10608.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
S100B	-0.0001706	9776	GTEx	DepMap	Descartes	1.70	378.89
FXYD1	-0.0002986	11550	GTEx	DepMap	Descartes	0.56	156.06
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17

Chromaffin cell development (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12477
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HAND2	-0.0006986	12451	GTEx	DepMap	Descartes	0.78	32.64
GATA3	-0.0008315	12503	GTEx	DepMap	Descartes	1.12	44.20

Meta5 unclear (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 12506.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN1	-0.0008231	12502	GTEx	DepMap	Descartes	5.54	284.85
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17

SCPs mouse and neuroblastoma (Olsen)
Similar to above, but for genes common to neuroblastoma SCP-like cells (as determined from their UMAP plot) and mouse SCP cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.94e-01
Mean rank of genes in gene set: 9000.82
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CNN3	0.0012696	467	GTEx	DepMap	Descartes	3.53	332.14
SEMA3B	0.0000428	4103	GTEx	DepMap	Descartes	0.91	56.74
DST	-0.0001201	8481	GTEx	DepMap	Descartes	2.27	17.11
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
LGI4	-0.0001581	9495	GTEx	DepMap	Descartes	0.24	23.13
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
S100B	-0.0001706	9776	GTEx	DepMap	Descartes	1.70	378.89
FXYD1	-0.0002986	11550	GTEx	DepMap	Descartes	0.56	156.06
GPM6B	-0.0003912	12065	GTEx	DepMap	Descartes	1.38	63.81
ERBB3	-0.0004902	12293	GTEx	DepMap	Descartes	0.28	9.17
NRXN1	-0.0006837	12446	GTEx	DepMap	Descartes	0.80	11.34

Committed Progenitor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Committed Progenitor subcluster (seems to mean progenitor of chromaffin cells), which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 8822.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NDUFA4L2	0.0015977	356	GTEx	DepMap	Descartes	6.01	970.68
RGS4	0.0003149	1729	GTEx	DepMap	Descartes	0.78	36.03
NRK	0.0002968	1812	GTEx	DepMap	Descartes	0.02	1.29
DGKK	-0.0000928	7694	GTEx	DepMap	Descartes	0.00	0.00
ZDBF2	-0.0001015	7953	GTEx	DepMap	Descartes	0.18	2.56
SYTL4	-0.0001087	8160	GTEx	DepMap	Descartes	0.14	5.68
UNC5C	-0.0001981	10297	GTEx	DepMap	Descartes	0.06	1.55
FAM155A	-0.0002191	10644	GTEx	DepMap	Descartes	0.17	2.14
ATP6V1B2	-0.0002457	11047	GTEx	DepMap	Descartes	0.36	8.71
SLC18A2	-0.0002520	11123	GTEx	DepMap	Descartes	0.04	1.02
NTRK3	-0.0003248	11732	GTEx	DepMap	Descartes	0.21	1.46
MEG3	-0.0005969	12400	GTEx	DepMap	Descartes	5.01	57.79
SYT1	-0.0006668	12440	GTEx	DepMap	Descartes	0.62	14.99
PARM1	-0.0006748	12443	GTEx	DepMap	Descartes	0.10	3.32
RGS5	-0.0008510	12505	GTEx	DepMap	Descartes	5.03	179.78

Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 12046.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BCL2	-0.0003073	11616	GTEx	DepMap	Descartes	0.25	5.98
NPY	-0.0004373	12193	GTEx	DepMap	Descartes	4.39	614.25
GAP43	-0.0005182	12330	GTEx	DepMap	Descartes	1.17	85.55

Sympathobasts or chromaffin (Kildisiute)
Sympathoblast and chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 12144
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGB	-0.0003860	12040	GTEx	DepMap	Descartes	0.87	37.31
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53

Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12154.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EIF3F	-0.0003288	11770	GTEx	DepMap	Descartes	2.47	53.04
EIF3E	-0.0004639	12249	GTEx	DepMap	Descartes	3.39	265.81
EIF3L	-0.0006789	12444	GTEx	DepMap	Descartes	2.38	106.72

Chromaffin Cells (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: the neuronal markers NPY, PRPH, NTRK1 and ISL1 are used to annotate chromaffin cells; these were clearly expressed in neuroblasts in our analyses.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12213
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0003232	11719	GTEx	DepMap	Descartes	0.10	2.76
PHOX2A	-0.0007005	12452	GTEx	DepMap	Descartes	1.76	109.82
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85

Meta_7 undefined sympathetic (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12247.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29
TUBB2A	-0.0005389	12354	GTEx	DepMap	Descartes	1.71	124.52

E Chromaffin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 10586.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RAB3B	0.0000460	4064	GTEx	DepMap	Descartes	0.07	0.79
DLK1	-0.0002172	10608	GTEx	DepMap	Descartes	0.20	7.81
RAB3C	-0.0004346	12182	GTEx	DepMap	Descartes	0.11	1.45
NPY	-0.0004373	12193	GTEx	DepMap	Descartes	4.39	614.25
GATA2	-0.0004392	12199	GTEx	DepMap	Descartes	0.20	9.37
ANK3	-0.0004753	12272	GTEx	DepMap	Descartes	0.31	2.13

Bridge region adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12503.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MLLT11	-0.0007907	12494	GTEx	DepMap	Descartes	1.67	82.91
RGS5	-0.0008510	12505	GTEx	DepMap	Descartes	5.03	179.78
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17

Chromaffin and connecting progenitor cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12173.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DDC	-0.0003849	12037	GTEx	DepMap	Descartes	0.10	6.06
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53

Late chromaffin cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: this late chromaffin cell signature also includes PNMT, which is an enzyme catalyzing methylation of norepinephrine to form epinephrine; this marker is absent from the ealier less differentiated chromaffin cells (which may have been referred to as sympathoblasts in other datasets, I think):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12173.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DDC	-0.0003849	12037	GTEx	DepMap	Descartes	0.10	6.06
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53

Bridge region SCP-adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP-adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12268.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SRP14	-0.0003825	12028	GTEx	DepMap	Descartes	8.59	1412.94
PCBP2	-0.0004528	12228	GTEx	DepMap	Descartes	3.39	173.13
HMGB1	-0.0005293	12347	GTEx	DepMap	Descartes	10.41	331.21
MDK	-0.0007360	12471	GTEx	DepMap	Descartes	4.32	605.08

Bridge (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Bridge subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9846
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DPYSL3	0.0004111	1372	GTEx	DepMap	Descartes	1.07	36.10
RCC2	0.0000846	3506	GTEx	DepMap	Descartes	0.59	22.54
TBX20	-0.0000894	7593	GTEx	DepMap	Descartes	0.00	0.00
GSE1	-0.0001624	9584	GTEx	DepMap	Descartes	0.27	NA
WDR6	-0.0002760	11377	GTEx	DepMap	Descartes	0.32	12.08
DLL3	-0.0003049	11603	GTEx	DepMap	Descartes	0.14	6.48
CDKN1C	-0.0003442	11860	GTEx	DepMap	Descartes	0.57	54.27
MIAT	-0.0003680	11969	GTEx	DepMap	Descartes	0.19	2.07
NFASC	-0.0003773	12009	GTEx	DepMap	Descartes	0.22	3.35
SOX11	-0.0005507	12373	GTEx	DepMap	Descartes	1.00	14.51
LDHB	-0.0006224	12415	GTEx	DepMap	Descartes	4.76	505.66
CKB	-0.0007853	12491	GTEx	DepMap	Descartes	2.30	223.94

IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11820.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ISG20	-0.0001723	9814	GTEx	DepMap	Descartes	0.44	16.92
IFIT2	-0.0003574	11926	GTEx	DepMap	Descartes	0.55	40.48
IFIT1	-0.0006117	12407	GTEx	DepMap	Descartes	1.50	65.37
IFIT3	-0.0006456	12425	GTEx	DepMap	Descartes	1.63	130.55
ISG15	-0.0012303	12530	GTEx	DepMap	Descartes	12.76	3340.60

Symphathoblasts (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. Several of these markers are also (more weakly) expressed in chromaffin cells. The authors data suggest Symphthoblasts give rise to chromaffin cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12482
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ELAVL4	-0.0007123	12460	GTEx	DepMap	Descartes	1.45	35.35
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85
ELAVL3	-0.0007799	12489	GTEx	DepMap	Descartes	0.62	15.37
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17

Late Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: the Jansky Late Neuroblast signature is the same as the earlier Neuroblast signature, but NEFM and ALK are now absent (meaning lower expressed at later stages of differentiation):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12020.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SYN3	-0.0002329	10869	GTEx	DepMap	Descartes	0.04	0.43
IL7	-0.0003571	11925	GTEx	DepMap	Descartes	0.18	10.70
GAP43	-0.0005182	12330	GTEx	DepMap	Descartes	1.17	85.55
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17

N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9689.12
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCL14	0.0007298	837	GTEx	DepMap	Descartes	0.36	47.50
CACNA2D1	0.0003494	1591	GTEx	DepMap	Descartes	0.34	8.78
LGR5	-0.0000202	5482	GTEx	DepMap	Descartes	0.00	0.00
ADCYAP1R1	-0.0000771	7220	GTEx	DepMap	Descartes	0.05	1.03
SYN2	-0.0001510	9332	GTEx	DepMap	Descartes	0.02	0.27
PPFIA2	-0.0002005	10337	GTEx	DepMap	Descartes	0.04	0.71
PTPRN	-0.0002389	10951	GTEx	DepMap	Descartes	0.12	3.03
SLCO3A1	-0.0003284	11768	GTEx	DepMap	Descartes	0.37	13.66
NAP1L5	-0.0003391	11837	GTEx	DepMap	Descartes	0.23	16.64
PCLO	-0.0003694	11974	GTEx	DepMap	Descartes	0.15	0.88
SCG5	-0.0003894	12053	GTEx	DepMap	Descartes	0.91	118.04
C1QL1	-0.0004220	12154	GTEx	DepMap	Descartes	0.29	26.73
CELF4	-0.0004865	12291	GTEx	DepMap	Descartes	0.60	12.82
SNAP25	-0.0005499	12372	GTEx	DepMap	Descartes	0.28	13.64
GNAS	-0.0005931	12397	GTEx	DepMap	Descartes	11.47	480.32
SCG3	-0.0006507	12430	GTEx	DepMap	Descartes	0.50	14.61

Symphathoblasts Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for symphathoblasts (differentiating from SCPs):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12423
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ELAVL2	-0.0004515	12225	GTEx	DepMap	Descartes	0.38	10.13
HAND2	-0.0006986	12451	GTEx	DepMap	Descartes	0.78	32.64
ELAVL4	-0.0007123	12460	GTEx	DepMap	Descartes	1.45	35.35
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17

Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11689.14
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALK	-0.0001661	9674	GTEx	DepMap	Descartes	0.03	0.70
SYN3	-0.0002329	10869	GTEx	DepMap	Descartes	0.04	0.43
IL7	-0.0003571	11925	GTEx	DepMap	Descartes	0.18	10.70
NEFM	-0.0003878	12047	GTEx	DepMap	Descartes	0.38	13.00
GAP43	-0.0005182	12330	GTEx	DepMap	Descartes	1.17	85.55
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17

Broad sympathetic marker (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12264.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGB	-0.0003860	12040	GTEx	DepMap	Descartes	0.87	37.31
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
GATA2	-0.0004392	12199	GTEx	DepMap	Descartes	0.20	9.37
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53
HAND2	-0.0006986	12451	GTEx	DepMap	Descartes	0.78	32.64
GATA3	-0.0008315	12503	GTEx	DepMap	Descartes	1.12	44.20

Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12190
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	-0.0001778	9926	GTEx	DepMap	Descartes	0.03	0.26
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53
UCHL1	-0.0005398	12357	GTEx	DepMap	Descartes	2.99	223.77
ELAVL4	-0.0007123	12460	GTEx	DepMap	Descartes	1.45	35.35
MAP1B	-0.0007228	12465	GTEx	DepMap	Descartes	4.78	59.60
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85
MLLT11	-0.0007907	12494	GTEx	DepMap	Descartes	1.67	82.91
RGS5	-0.0008510	12505	GTEx	DepMap	Descartes	5.03	179.78
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17
RTN1	-0.0009309	12512	GTEx	DepMap	Descartes	1.91	55.48

Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12385.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEFM	-0.0003878	12047	GTEx	DepMap	Descartes	0.38	13.00
NEFL	-0.0003906	12063	GTEx	DepMap	Descartes	0.25	9.86
INA	-0.0005256	12342	GTEx	DepMap	Descartes	0.39	12.03
CCND1	-0.0005755	12391	GTEx	DepMap	Descartes	3.93	144.78
BASP1	-0.0007025	12454	GTEx	DepMap	Descartes	3.13	243.39
ELAVL4	-0.0007123	12460	GTEx	DepMap	Descartes	1.45	35.35
ISL1	-0.0007317	12468	GTEx	DepMap	Descartes	0.45	23.85
ELAVL3	-0.0007799	12489	GTEx	DepMap	Descartes	0.62	15.37
STMN1	-0.0008231	12502	GTEx	DepMap	Descartes	5.54	284.85
STMN2	-0.0009214	12511	GTEx	DepMap	Descartes	5.73	325.17
RTN1	-0.0009309	12512	GTEx	DepMap	Descartes	1.91	55.48

Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11960.44
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CYB561	-0.0002028	10373	GTEx	DepMap	Descartes	0.31	18.94
SLC18A1	-0.0002050	10407	GTEx	DepMap	Descartes	0.05	1.93
DISP2	-0.0002287	10805	GTEx	DepMap	Descartes	0.03	0.25
EML5	-0.0003483	11887	GTEx	DepMap	Descartes	0.07	1.07
DDC	-0.0003849	12037	GTEx	DepMap	Descartes	0.10	6.06
CHGB	-0.0003860	12040	GTEx	DepMap	Descartes	0.87	37.31
DBH	-0.0004117	12123	GTEx	DepMap	Descartes	0.46	16.99
CHGA	-0.0004726	12266	GTEx	DepMap	Descartes	0.49	21.29
TH	-0.0004750	12269	GTEx	DepMap	Descartes	0.14	9.53
UCHL1	-0.0005398	12357	GTEx	DepMap	Descartes	2.99	223.77
NNAT	-0.0006599	12436	GTEx	DepMap	Descartes	0.66	52.25
HAND2	-0.0006986	12451	GTEx	DepMap	Descartes	0.78	32.64
PHOX2A	-0.0007005	12452	GTEx	DepMap	Descartes	1.76	109.82
MAP1B	-0.0007228	12465	GTEx	DepMap	Descartes	4.78	59.60
PCSK1N	-0.0007944	12496	GTEx	DepMap	Descartes	1.91	195.38
GATA3	-0.0008315	12503	GTEx	DepMap	Descartes	1.12	44.20

Plasmacytoid dendritic cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Adrenal Cortex (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Symphatoblasts (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: Sympathoblasts were identified by Dong et al.28 based on the expression of CARTPT and INSM1, which we found expressed in chromaffin cells:
Autonomic neurons mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Erythroblast (Kildisiute)
Erythroblast markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Chromaffin (Kildisiute)
Chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Cortex (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for their broad Cortex group, which is composed of Fetal Zone, Definitive Zone and Adr Primordium subclusters:
Adrenal cortical (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that CYP11A1+ Adrenal cortical cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:

Below shows ranks on this GEP for literature curated gene lists for large gene sets
These include those reported as mesenchymal/adrenergic by Van Groningen et al.
High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10306.95
Median rank of genes in gene set: 11569
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
STRA6	0.0011976	505	GTEx	DepMap	Descartes	0.07	4.89
TUBB4B	0.0006743	903	GTEx	DepMap	Descartes	2.95	269.75
DPYSL3	0.0004111	1372	GTEx	DepMap	Descartes	1.07	36.10
CSE1L	0.0003994	1411	GTEx	DepMap	Descartes	0.34	16.26
SETD7	0.0003332	1645	GTEx	DepMap	Descartes	0.26	6.53
CDKN3	0.0003324	1650	GTEx	DepMap	Descartes	0.59	110.78
PHPT1	0.0003199	1703	GTEx	DepMap	Descartes	3.95	544.88
GNB1	0.0003132	1738	GTEx	DepMap	Descartes	1.61	91.08
GLRX	0.0003117	1746	GTEx	DepMap	Descartes	0.74	39.28
RRM2	0.0002333	2132	GTEx	DepMap	Descartes	0.34	15.66
NCS1	0.0001864	2464	GTEx	DepMap	Descartes	0.55	17.01
HK2	0.0001749	2540	GTEx	DepMap	Descartes	0.11	3.73
FOXM1	0.0001517	2765	GTEx	DepMap	Descartes	0.20	9.40
PDK1	0.0001490	2792	GTEx	DepMap	Descartes	0.09	1.06
EXOC5	0.0001299	2970	GTEx	DepMap	Descartes	0.36	6.80
AKAP12	0.0000913	3405	GTEx	DepMap	Descartes	1.88	36.15
NFIL3	0.0000597	3850	GTEx	DepMap	Descartes	0.31	30.88
GGCT	0.0000364	4203	GTEx	DepMap	Descartes	0.88	127.74
GRB10	0.0000324	4259	GTEx	DepMap	Descartes	0.22	8.95
EML4	0.0000318	4270	GTEx	DepMap	Descartes	0.38	13.45
MCM2	0.0000177	4553	GTEx	DepMap	Descartes	0.13	4.66
SHC3	0.0000174	4561	GTEx	DepMap	Descartes	0.02	0.30
KIF15	0.0000136	4627	GTEx	DepMap	Descartes	0.05	2.46
RFC4	0.0000043	4816	GTEx	DepMap	Descartes	0.22	22.46
NPTX2	0.0000023	4865	GTEx	DepMap	Descartes	0.08	6.64
FBXO8	-0.0000139	5297	GTEx	DepMap	Descartes	0.28	24.72
LSM3	-0.0000152	5337	GTEx	DepMap	Descartes	2.27	119.53
CDC42EP3	-0.0000189	5446	GTEx	DepMap	Descartes	0.60	21.01
TIAM1	-0.0000208	5511	GTEx	DepMap	Descartes	0.20	5.55
LYN	-0.0000239	5600	GTEx	DepMap	Descartes	0.15	3.62

VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.48e-114
Mean rank of genes in gene set: 2404.34
Median rank of genes in gene set: 901
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
FN1	0.0194227	4	GTEx	DepMap	Descartes	21.78	512.24
COL6A3	0.0192235	5	GTEx	DepMap	Descartes	4.23	100.11
COL5A1	0.0179003	6	GTEx	DepMap	Descartes	2.72	75.23
LOXL2	0.0162635	11	GTEx	DepMap	Descartes	1.64	93.14
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
CCDC80	0.0128195	17	GTEx	DepMap	Descartes	5.03	99.53
COL6A2	0.0124972	18	GTEx	DepMap	Descartes	10.27	656.45
BGN	0.0120244	20	GTEx	DepMap	Descartes	7.99	756.33
TNC	0.0116712	21	GTEx	DepMap	Descartes	2.52	55.91
COL5A2	0.0116344	22	GTEx	DepMap	Descartes	3.14	93.69
TIMP1	0.0113753	23	GTEx	DepMap	Descartes	59.35	10946.50
THBS1	0.0110827	24	GTEx	DepMap	Descartes	3.06	73.78
LGALS1	0.0110307	25	GTEx	DepMap	Descartes	51.04	16051.62
SPARC	0.0108130	27	GTEx	DepMap	Descartes	26.81	1596.61
FBN1	0.0107290	28	GTEx	DepMap	Descartes	1.39	27.74
COL6A1	0.0105974	29	GTEx	DepMap	Descartes	7.15	347.83
SERPINH1	0.0098135	30	GTEx	DepMap	Descartes	4.13	226.23
PLOD2	0.0094017	31	GTEx	DepMap	Descartes	0.93	52.44
MICAL2	0.0085984	36	GTEx	DepMap	Descartes	0.59	23.13
FSTL1	0.0082558	38	GTEx	DepMap	Descartes	2.84	99.93
TPM2	0.0077177	42	GTEx	DepMap	Descartes	11.38	1297.18
KDELR3	0.0075803	43	GTEx	DepMap	Descartes	0.86	84.24
FLNA	0.0075326	44	GTEx	DepMap	Descartes	4.74	112.41
VIM	0.0070253	45	GTEx	DepMap	Descartes	62.85	4335.51
PPIC	0.0068987	47	GTEx	DepMap	Descartes	1.30	195.21
GPX8	0.0067753	48	GTEx	DepMap	Descartes	0.95	51.12
EMILIN1	0.0067363	49	GTEx	DepMap	Descartes	1.66	108.73
MRC2	0.0064169	57	GTEx	DepMap	Descartes	0.53	20.25

Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.64e-01
Mean rank of genes in gene set: 7361.5
Median rank of genes in gene set: 7433.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
PAPSS2	0.0027728	182	GTEx	DepMap	Descartes	0.36	15.65
SH3PXD2B	0.0005872	1017	GTEx	DepMap	Descartes	0.21	4.29
IGF1R	0.0002652	1948	GTEx	DepMap	Descartes	0.32	3.60
FREM2	0.0001974	2364	GTEx	DepMap	Descartes	0.02	0.13
POR	0.0001914	2417	GTEx	DepMap	Descartes	0.33	24.96
SCAP	0.0001121	3158	GTEx	DepMap	Descartes	0.21	7.87
LDLR	0.0000689	3720	GTEx	DepMap	Descartes	0.25	7.38
GRAMD1B	0.0000305	4300	GTEx	DepMap	Descartes	0.09	1.94
DHCR7	0.0000264	4384	GTEx	DepMap	Descartes	0.07	4.40
NPC1	0.0000004	4903	GTEx	DepMap	Descartes	0.10	4.38
FRMD5	-0.0000100	5188	GTEx	DepMap	Descartes	0.10	2.46
STAR	-0.0000112	5216	GTEx	DepMap	Descartes	0.01	0.29
PDE10A	-0.0000179	5417	GTEx	DepMap	Descartes	0.09	2.41
CYB5B	-0.0000199	5472	GTEx	DepMap	Descartes	0.36	16.55
SH3BP5	-0.0000284	5750	GTEx	DepMap	Descartes	0.70	39.82
FDXR	-0.0000627	6767	GTEx	DepMap	Descartes	0.14	10.24
BAIAP2L1	-0.0000702	7008	GTEx	DepMap	Descartes	0.01	0.21
INHA	-0.0000774	7227	GTEx	DepMap	Descartes	0.00	0.00
ERN1	-0.0000908	7640	GTEx	DepMap	Descartes	0.14	2.66
SGCZ	-0.0001150	8344	GTEx	DepMap	Descartes	0.00	0.00
DHCR24	-0.0001358	8908	GTEx	DepMap	Descartes	0.12	3.87
SLC16A9	-0.0001399	9018	GTEx	DepMap	Descartes	0.03	1.22
FDPS	-0.0001487	9265	GTEx	DepMap	Descartes	1.13	91.84
SCARB1	-0.0001581	9496	GTEx	DepMap	Descartes	0.06	1.33
HMGCR	-0.0001727	9821	GTEx	DepMap	Descartes	0.15	5.80
MSMO1	-0.0001902	10159	GTEx	DepMap	Descartes	0.21	12.56
HMGCS1	-0.0002334	10880	GTEx	DepMap	Descartes	0.22	7.27
APOC1	-0.0002387	10946	GTEx	DepMap	Descartes	2.80	719.42
PEG3	-0.0002833	11440	GTEx	DepMap	Descartes	0.18	NA
FDX1	-0.0002894	11489	GTEx	DepMap	Descartes	0.62	36.56

Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10767
Median rank of genes in gene set: 11645
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
GREM1	0.0054888	69	GTEx	DepMap	Descartes	0.48	8.42
FAT3	-0.0000100	5186	GTEx	DepMap	Descartes	0.10	1.46
RGMB	-0.0000213	5523	GTEx	DepMap	Descartes	0.26	9.63
SLC44A5	-0.0000896	7603	GTEx	DepMap	Descartes	0.00	0.00
ANKFN1	-0.0001057	8067	GTEx	DepMap	Descartes	0.00	0.00
EPHA6	-0.0001231	8569	GTEx	DepMap	Descartes	0.02	0.30
RPH3A	-0.0001513	9341	GTEx	DepMap	Descartes	0.01	0.13
ALK	-0.0001661	9674	GTEx	DepMap	Descartes	0.03	0.70
RYR2	-0.0001680	9714	GTEx	DepMap	Descartes	0.06	0.25
HS3ST5	-0.0001819	10023	GTEx	DepMap	Descartes	0.01	0.11
CNKSR2	-0.0001996	10324	GTEx	DepMap	Descartes	0.05	0.68
KCNB2	-0.0002264	10771	GTEx	DepMap	Descartes	0.03	0.54
PTCHD1	-0.0002306	10832	GTEx	DepMap	Descartes	0.05	0.23
TMEFF2	-0.0002382	10940	GTEx	DepMap	Descartes	0.10	2.72
PLXNA4	-0.0002451	11039	GTEx	DepMap	Descartes	0.07	0.81
EYA1	-0.0002460	11051	GTEx	DepMap	Descartes	0.03	0.38
EYA4	-0.0002633	11257	GTEx	DepMap	Descartes	0.01	0.07
REEP1	-0.0002867	11469	GTEx	DepMap	Descartes	0.14	4.38
TMEM132C	-0.0002971	11541	GTEx	DepMap	Descartes	0.01	0.36
SLC6A2	-0.0003013	11574	GTEx	DepMap	Descartes	0.05	1.48
RBFOX1	-0.0003112	11645	GTEx	DepMap	Descartes	0.01	0.62
NTRK1	-0.0003232	11719	GTEx	DepMap	Descartes	0.10	2.76
MAB21L2	-0.0003272	11760	GTEx	DepMap	Descartes	0.38	15.18
SYNPO2	-0.0003292	11773	GTEx	DepMap	Descartes	0.46	5.34
IL7	-0.0003571	11925	GTEx	DepMap	Descartes	0.18	10.70
NPY	-0.0004373	12193	GTEx	DepMap	Descartes	4.39	614.25
CNTFR	-0.0004394	12201	GTEx	DepMap	Descartes	0.12	5.21
GAL	-0.0004427	12209	GTEx	DepMap	Descartes	0.35	75.40
ELAVL2	-0.0004515	12225	GTEx	DepMap	Descartes	0.38	10.13
GAP43	-0.0005182	12330	GTEx	DepMap	Descartes	1.17	85.55

Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.15e-01
Mean rank of genes in gene set: 6149.39
Median rank of genes in gene set: 6509
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CDH13	0.0041800	101	GTEx	DepMap	Descartes	0.49	10.20
EHD3	0.0014190	407	GTEx	DepMap	Descartes	0.10	5.41
TEK	0.0013010	453	GTEx	DepMap	Descartes	0.09	3.23
PTPRB	0.0010469	578	GTEx	DepMap	Descartes	0.30	3.63
RASIP1	0.0007565	817	GTEx	DepMap	Descartes	0.19	11.14
PODXL	0.0006042	987	GTEx	DepMap	Descartes	0.51	14.57
NPR1	0.0004743	1213	GTEx	DepMap	Descartes	0.05	2.36
SHE	0.0003188	1710	GTEx	DepMap	Descartes	0.09	2.84
F8	0.0001047	3230	GTEx	DepMap	Descartes	0.03	0.53
NR5A2	0.0001006	3282	GTEx	DepMap	Descartes	0.01	0.54
CDH5	0.0000602	3843	GTEx	DepMap	Descartes	0.43	17.61
SLCO2A1	0.0000461	4061	GTEx	DepMap	Descartes	0.06	2.66
TIE1	0.0000243	4417	GTEx	DepMap	Descartes	0.16	7.44
BTNL9	0.0000144	4614	GTEx	DepMap	Descartes	0.01	0.23
CYP26B1	0.0000018	4877	GTEx	DepMap	Descartes	0.19	4.56
CLDN5	-0.0000110	5211	GTEx	DepMap	Descartes	0.86	54.97
SHANK3	-0.0000111	5214	GTEx	DepMap	Descartes	0.03	0.46
ID1	-0.0000456	6250	GTEx	DepMap	Descartes	1.16	190.27
CRHBP	-0.0000511	6434	GTEx	DepMap	Descartes	0.03	2.47
MYRIP	-0.0000564	6584	GTEx	DepMap	Descartes	0.01	0.36
CEACAM1	-0.0000619	6730	GTEx	DepMap	Descartes	0.00	0.00
CALCRL	-0.0000710	7032	GTEx	DepMap	Descartes	0.22	7.44
GALNT15	-0.0000718	7061	GTEx	DepMap	Descartes	0.03	NA
TMEM88	-0.0000805	7313	GTEx	DepMap	Descartes	0.05	5.81
MMRN2	-0.0000896	7602	GTEx	DepMap	Descartes	0.20	7.24
ROBO4	-0.0000910	7643	GTEx	DepMap	Descartes	0.23	8.87
ESM1	-0.0001298	8749	GTEx	DepMap	Descartes	0.36	22.08
FLT4	-0.0001496	9291	GTEx	DepMap	Descartes	0.09	3.96
IRX3	-0.0001515	9344	GTEx	DepMap	Descartes	0.03	2.49
NOTCH4	-0.0001755	9886	GTEx	DepMap	Descartes	0.29	6.96

Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.84e-13
Mean rank of genes in gene set: 2313.02
Median rank of genes in gene set: 553.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
POSTN	0.0266853	1	GTEx	DepMap	Descartes	7.14	477.97
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
COL6A3	0.0192235	5	GTEx	DepMap	Descartes	4.23	100.11
LOX	0.0169898	9	GTEx	DepMap	Descartes	1.41	65.63
COL3A1	0.0157377	13	GTEx	DepMap	Descartes	16.03	706.64
CCDC80	0.0128195	17	GTEx	DepMap	Descartes	5.03	99.53
ITGA11	0.0065499	53	GTEx	DepMap	Descartes	0.22	5.36
COL12A1	0.0064047	58	GTEx	DepMap	Descartes	1.31	19.46
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
ISLR	0.0037802	122	GTEx	DepMap	Descartes	0.43	50.00
CDH11	0.0032645	147	GTEx	DepMap	Descartes	1.07	34.00
CD248	0.0029727	167	GTEx	DepMap	Descartes	0.63	52.21
EDNRA	0.0024719	216	GTEx	DepMap	Descartes	0.54	29.29
ADAMTS2	0.0023746	231	GTEx	DepMap	Descartes	0.39	9.94
LRRC17	0.0020803	267	GTEx	DepMap	Descartes	0.11	10.57
COL27A1	0.0017353	324	GTEx	DepMap	Descartes	0.20	5.77
ACTA2	0.0016972	334	GTEx	DepMap	Descartes	14.32	1426.99
GLI2	0.0015660	364	GTEx	DepMap	Descartes	0.08	3.57
BICC1	0.0012918	457	GTEx	DepMap	Descartes	0.31	12.47
ABCA6	0.0011991	504	GTEx	DepMap	Descartes	0.21	6.11
PCDH18	0.0011131	539	GTEx	DepMap	Descartes	0.29	11.08
PCOLCE	0.0010637	568	GTEx	DepMap	Descartes	2.43	359.95
MGP	0.0007771	794	GTEx	DepMap	Descartes	14.30	2016.04
C7	0.0007499	820	GTEx	DepMap	Descartes	0.38	14.91
DKK2	0.0006251	956	GTEx	DepMap	Descartes	0.03	1.88
ELN	0.0005996	995	GTEx	DepMap	Descartes	0.57	29.65
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41
LUM	0.0004614	1239	GTEx	DepMap	Descartes	4.61	490.99
ADAMTSL3	0.0003564	1559	GTEx	DepMap	Descartes	0.05	1.67

Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8676.76
Median rank of genes in gene set: 9088
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ROBO1	0.0004064	1385	GTEx	DepMap	Descartes	0.39	8.83
PENK	0.0002130	2250	GTEx	DepMap	Descartes	0.30	68.76
LAMA3	0.0000206	4498	GTEx	DepMap	Descartes	0.03	0.60
ST18	-0.0000166	5379	GTEx	DepMap	Descartes	0.02	0.58
TIAM1	-0.0000208	5511	GTEx	DepMap	Descartes	0.20	5.55
SORCS3	-0.0000403	6087	GTEx	DepMap	Descartes	0.01	0.22
AGBL4	-0.0000423	6151	GTEx	DepMap	Descartes	0.03	0.72
SLC24A2	-0.0000489	6356	GTEx	DepMap	Descartes	0.00	0.00
GRM7	-0.0000546	6518	GTEx	DepMap	Descartes	0.00	0.00
SLC35F3	-0.0000713	7041	GTEx	DepMap	Descartes	0.00	0.00
CDH18	-0.0000747	7150	GTEx	DepMap	Descartes	0.00	0.00
CNTN3	-0.0000756	7180	GTEx	DepMap	Descartes	0.01	0.12
TBX20	-0.0000894	7593	GTEx	DepMap	Descartes	0.00	0.00
DGKK	-0.0000928	7694	GTEx	DepMap	Descartes	0.00	0.00
CCSER1	-0.0001054	8057	GTEx	DepMap	Descartes	0.01	NA
TENM1	-0.0001155	8357	GTEx	DepMap	Descartes	0.01	NA
CDH12	-0.0001254	8625	GTEx	DepMap	Descartes	0.00	0.00
PACRG	-0.0001357	8907	GTEx	DepMap	Descartes	0.01	0.24
EML6	-0.0001378	8965	GTEx	DepMap	Descartes	0.02	0.24
FGF14	-0.0001468	9211	GTEx	DepMap	Descartes	0.01	0.03
KSR2	-0.0001558	9441	GTEx	DepMap	Descartes	0.03	0.14
SPOCK3	-0.0001590	9513	GTEx	DepMap	Descartes	0.02	0.38
PCSK2	-0.0001673	9699	GTEx	DepMap	Descartes	0.03	0.87
GALNTL6	-0.0001713	9793	GTEx	DepMap	Descartes	0.01	0.11
GRID2	-0.0001867	10100	GTEx	DepMap	Descartes	0.05	0.49
NTNG1	-0.0001888	10137	GTEx	DepMap	Descartes	0.13	2.69
SLC18A1	-0.0002050	10407	GTEx	DepMap	Descartes	0.05	1.93
MGAT4C	-0.0002133	10543	GTEx	DepMap	Descartes	0.07	0.17
FAM155A	-0.0002191	10644	GTEx	DepMap	Descartes	0.17	2.14
UNC80	-0.0002543	11151	GTEx	DepMap	Descartes	0.07	0.98

Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.98e-01
Mean rank of genes in gene set: 6101.48
Median rank of genes in gene set: 5437
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
MICAL2	0.0085984	36	GTEx	DepMap	Descartes	0.59	23.13
MARCH3	0.0017335	325	GTEx	DepMap	Descartes	0.26	NA
GYPC	0.0007646	807	GTEx	DepMap	Descartes	1.63	170.25
TSPAN5	0.0003112	1747	GTEx	DepMap	Descartes	0.71	34.47
BLVRB	0.0003068	1765	GTEx	DepMap	Descartes	0.76	105.06
SLC25A37	0.0002447	2067	GTEx	DepMap	Descartes	0.49	20.19
CPOX	0.0002224	2192	GTEx	DepMap	Descartes	0.14	8.33
TRAK2	0.0001784	2512	GTEx	DepMap	Descartes	0.16	4.95
SELENBP1	0.0000496	3991	GTEx	DepMap	Descartes	0.12	11.19
ABCB10	0.0000495	3994	GTEx	DepMap	Descartes	0.07	3.35
GCLC	0.0000089	4711	GTEx	DepMap	Descartes	0.11	7.08
ALAS2	0.0000040	4822	GTEx	DepMap	Descartes	0.00	0.00
CAT	0.0000003	4905	GTEx	DepMap	Descartes	0.31	20.50
RHD	-0.0000117	5231	GTEx	DepMap	Descartes	0.00	0.00
SLC4A1	-0.0000186	5437	GTEx	DepMap	Descartes	0.01	0.31
SPECC1	-0.0000256	5664	GTEx	DepMap	Descartes	0.23	5.21
SLC25A21	-0.0000529	6485	GTEx	DepMap	Descartes	0.00	0.00
ANK1	-0.0000778	7239	GTEx	DepMap	Descartes	0.04	0.47
TMCC2	-0.0001096	8192	GTEx	DepMap	Descartes	0.03	0.72
FECH	-0.0001162	8381	GTEx	DepMap	Descartes	0.05	1.04
DENND4A	-0.0001188	8445	GTEx	DepMap	Descartes	0.23	4.47
XPO7	-0.0001491	9277	GTEx	DepMap	Descartes	0.18	5.80
SOX6	-0.0002003	10334	GTEx	DepMap	Descartes	0.08	1.87
SPTB	-0.0002097	10491	GTEx	DepMap	Descartes	0.01	0.04
TFR2	-0.0002102	10498	GTEx	DepMap	Descartes	0.05	1.66
RAPGEF2	-0.0003259	11743	GTEx	DepMap	Descartes	0.27	5.76
SNCA	-0.0003264	11751	GTEx	DepMap	Descartes	0.25	10.50
EPB41	-0.0003315	11789	GTEx	DepMap	Descartes	0.11	2.92
RGS6	-0.0004093	12112	GTEx	DepMap	Descartes	0.01	0.13
NA	NA	NA	NA	NA	NA	NA	NA

Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.01e-01
Mean rank of genes in gene set: 6770.74
Median rank of genes in gene set: 7364
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
TGFBI	0.0048626	84	GTEx	DepMap	Descartes	3.74	175.80
AXL	0.0012899	458	GTEx	DepMap	Descartes	0.84	34.80
HRH1	0.0007405	827	GTEx	DepMap	Descartes	0.11	3.37
CTSC	0.0002484	2043	GTEx	DepMap	Descartes	1.53	46.53
ABCA1	0.0002349	2123	GTEx	DepMap	Descartes	0.30	7.15
CST3	0.0002086	2279	GTEx	DepMap	Descartes	12.74	787.94
PTPRE	0.0001441	2847	GTEx	DepMap	Descartes	0.58	17.29
ITPR2	0.0001090	3194	GTEx	DepMap	Descartes	0.31	4.13
WWP1	0.0000904	3425	GTEx	DepMap	Descartes	0.25	11.46
RGL1	0.0000410	4127	GTEx	DepMap	Descartes	0.20	10.61
RBPJ	0.0000401	4148	GTEx	DepMap	Descartes	0.72	21.61
FMN1	-0.0000157	5355	GTEx	DepMap	Descartes	0.18	1.62
CTSB	-0.0000236	5594	GTEx	DepMap	Descartes	2.18	110.38
HCK	-0.0000258	5671	GTEx	DepMap	Descartes	0.10	7.90
SLC9A9	-0.0000356	5962	GTEx	DepMap	Descartes	0.09	4.62
SLC1A3	-0.0000497	6390	GTEx	DepMap	Descartes	0.04	1.35
SLCO2B1	-0.0000660	6863	GTEx	DepMap	Descartes	0.15	5.44
CD14	-0.0000677	6914	GTEx	DepMap	Descartes	0.38	41.75
CSF1R	-0.0000773	7225	GTEx	DepMap	Descartes	0.09	4.31
CYBB	-0.0000861	7503	GTEx	DepMap	Descartes	0.11	3.64
FGD2	-0.0000932	7705	GTEx	DepMap	Descartes	0.01	0.78
CD163	-0.0001063	8081	GTEx	DepMap	Descartes	0.08	2.02
IFNGR1	-0.0001078	8130	GTEx	DepMap	Descartes	0.45	35.52
ATP8B4	-0.0001107	8224	GTEx	DepMap	Descartes	0.01	0.21
MERTK	-0.0001391	8999	GTEx	DepMap	Descartes	0.07	1.54
CTSS	-0.0001392	9000	GTEx	DepMap	Descartes	0.59	28.72
SFMBT2	-0.0001516	9349	GTEx	DepMap	Descartes	0.02	0.48
MS4A4A	-0.0001667	9683	GTEx	DepMap	Descartes	0.11	6.16
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26
CTSD	-0.0001710	9785	GTEx	DepMap	Descartes	2.14	202.23

Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.85e-01
Mean rank of genes in gene set: 7452.34
Median rank of genes in gene set: 8597.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
COL5A2	0.0116344	22	GTEx	DepMap	Descartes	3.14	93.69
VIM	0.0070253	45	GTEx	DepMap	Descartes	62.85	4335.51
VCAN	0.0051682	75	GTEx	DepMap	Descartes	2.77	49.22
HMGA2	0.0035172	134	GTEx	DepMap	Descartes	0.07	2.12
COL18A1	0.0027028	193	GTEx	DepMap	Descartes	5.61	168.71
LAMC1	0.0023676	233	GTEx	DepMap	Descartes	1.41	37.69
LAMA4	0.0020321	278	GTEx	DepMap	Descartes	2.17	63.89
LAMB1	0.0020082	284	GTEx	DepMap	Descartes	1.37	49.68
NRXN3	0.0012797	461	GTEx	DepMap	Descartes	0.14	4.62
KCTD12	0.0001641	2632	GTEx	DepMap	Descartes	0.65	24.17
MARCKS	0.0000640	3787	GTEx	DepMap	Descartes	8.02	319.98
GRIK3	0.0000313	4280	GTEx	DepMap	Descartes	0.03	0.74
MDGA2	-0.0000326	5855	GTEx	DepMap	Descartes	0.00	0.00
STARD13	-0.0000453	6240	GTEx	DepMap	Descartes	0.28	9.98
COL25A1	-0.0000699	7001	GTEx	DepMap	Descartes	0.00	0.00
LRRTM4	-0.0000866	7520	GTEx	DepMap	Descartes	0.01	1.31
TRPM3	-0.0000910	7642	GTEx	DepMap	Descartes	0.00	0.00
ADAMTS5	-0.0000956	7781	GTEx	DepMap	Descartes	0.15	2.82
EGFLAM	-0.0001009	7937	GTEx	DepMap	Descartes	0.21	6.61
GAS7	-0.0001171	8405	GTEx	DepMap	Descartes	0.59	14.61
DST	-0.0001201	8481	GTEx	DepMap	Descartes	2.27	17.11
IL1RAPL1	-0.0001208	8507	GTEx	DepMap	Descartes	0.01	1.03
SCN7A	-0.0001277	8688	GTEx	DepMap	Descartes	0.16	5.15
MPZ	-0.0001321	8814	GTEx	DepMap	Descartes	0.25	32.81
ERBB4	-0.0001329	8840	GTEx	DepMap	Descartes	0.03	0.44
PMP22	-0.0001584	9506	GTEx	DepMap	Descartes	1.99	211.92
PLP1	-0.0001595	9519	GTEx	DepMap	Descartes	0.57	40.13
XKR4	-0.0001627	9592	GTEx	DepMap	Descartes	0.05	0.37
PLCE1	-0.0001850	10063	GTEx	DepMap	Descartes	0.16	2.20
SORCS1	-0.0002077	10458	GTEx	DepMap	Descartes	0.06	1.86

Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.05e-04
Mean rank of genes in gene set: 4277.36
Median rank of genes in gene set: 2506
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
THBS1	0.0110827	24	GTEx	DepMap	Descartes	3.06	73.78
FLNA	0.0075326	44	GTEx	DepMap	Descartes	4.74	112.41
TPM4	0.0050635	78	GTEx	DepMap	Descartes	8.28	318.23
GP1BA	0.0045690	90	GTEx	DepMap	Descartes	0.14	12.02
ACTN1	0.0038407	115	GTEx	DepMap	Descartes	2.78	102.35
MYH9	0.0033821	140	GTEx	DepMap	Descartes	3.23	88.57
ACTB	0.0019886	287	GTEx	DepMap	Descartes	41.82	3507.95
VCL	0.0018326	301	GTEx	DepMap	Descartes	1.34	31.22
LTBP1	0.0017522	318	GTEx	DepMap	Descartes	0.47	13.49
TLN1	0.0015772	362	GTEx	DepMap	Descartes	2.28	44.30
TGFB1	0.0014679	393	GTEx	DepMap	Descartes	1.22	93.84
MYLK	0.0014343	401	GTEx	DepMap	Descartes	1.81	30.27
ZYX	0.0013955	421	GTEx	DepMap	Descartes	1.18	99.84
ITGB3	0.0009859	621	GTEx	DepMap	Descartes	0.00	0.00
SLC24A3	0.0009604	640	GTEx	DepMap	Descartes	0.05	3.60
ARHGAP6	0.0008533	725	GTEx	DepMap	Descartes	0.11	3.74
TMSB4X	0.0007294	838	GTEx	DepMap	Descartes	101.01	11015.74
SLC2A3	0.0006327	948	GTEx	DepMap	Descartes	0.91	41.63
LIMS1	0.0005222	1126	GTEx	DepMap	Descartes	2.32	81.22
RAP1B	0.0003974	1419	GTEx	DepMap	Descartes	1.55	21.89
PDE3A	0.0002849	1859	GTEx	DepMap	Descartes	0.18	4.50
STOM	0.0002303	2152	GTEx	DepMap	Descartes	1.24	78.60
UBASH3B	0.0001796	2506	GTEx	DepMap	Descartes	0.09	1.74
GSN	0.0001705	2578	GTEx	DepMap	Descartes	5.18	190.33
FLI1	0.0001632	2643	GTEx	DepMap	Descartes	0.06	2.81
CD9	0.0001177	3102	GTEx	DepMap	Descartes	2.17	232.46
MCTP1	0.0000436	4088	GTEx	DepMap	Descartes	0.09	3.00
TUBB1	0.0000094	4699	GTEx	DepMap	Descartes	0.01	1.08
P2RX1	-0.0000541	6506	GTEx	DepMap	Descartes	0.00	0.00
PSTPIP2	-0.0000669	6888	GTEx	DepMap	Descartes	0.01	0.53

Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 7615.79
Median rank of genes in gene set: 8680.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
TMSB10	0.0016365	347	GTEx	DepMap	Descartes	86.65	34808.85
ARID5B	0.0010335	586	GTEx	DepMap	Descartes	1.55	33.95
MSN	0.0009689	635	GTEx	DepMap	Descartes	1.77	83.47
MBNL1	0.0007456	821	GTEx	DepMap	Descartes	0.94	30.15
CD44	0.0004413	1289	GTEx	DepMap	Descartes	1.45	52.53
SP100	0.0001968	2372	GTEx	DepMap	Descartes	0.95	34.56
DOCK10	0.0001362	2912	GTEx	DepMap	Descartes	0.25	5.87
ETS1	0.0001256	3017	GTEx	DepMap	Descartes	0.87	32.77
FOXP1	0.0001169	3115	GTEx	DepMap	Descartes	1.15	22.95
PLEKHA2	0.0001096	3185	GTEx	DepMap	Descartes	0.18	7.61
WIPF1	0.0000973	3321	GTEx	DepMap	Descartes	0.40	19.62
CCND3	0.0000226	4462	GTEx	DepMap	Descartes	0.40	32.83
SAMD3	0.0000215	4483	GTEx	DepMap	Descartes	0.03	2.26
ABLIM1	-0.0000651	6839	GTEx	DepMap	Descartes	0.26	7.54
ITPKB	-0.0000695	6980	GTEx	DepMap	Descartes	0.09	2.67
STK39	-0.0000703	7013	GTEx	DepMap	Descartes	0.18	9.25
ARHGAP15	-0.0000721	7072	GTEx	DepMap	Descartes	0.40	28.39
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
ANKRD44	-0.0001034	8001	GTEx	DepMap	Descartes	0.13	2.34
MCTP2	-0.0001143	8326	GTEx	DepMap	Descartes	0.05	1.38
B2M	-0.0001214	8523	GTEx	DepMap	Descartes	76.91	6472.56
NCALD	-0.0001329	8838	GTEx	DepMap	Descartes	0.13	7.54
SKAP1	-0.0001403	9021	GTEx	DepMap	Descartes	0.06	8.47
PRKCH	-0.0001679	9713	GTEx	DepMap	Descartes	0.11	5.86
SORL1	-0.0001815	10008	GTEx	DepMap	Descartes	0.11	1.59
IKZF1	-0.0001869	10102	GTEx	DepMap	Descartes	0.03	0.73
LEF1	-0.0001899	10152	GTEx	DepMap	Descartes	0.13	9.07
SCML4	-0.0002069	10449	GTEx	DepMap	Descartes	0.01	0.09
BACH2	-0.0002115	10515	GTEx	DepMap	Descartes	0.11	1.74
PDE3B	-0.0002157	10584	GTEx	DepMap	Descartes	0.01	0.22

Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.05e-02
Mean rank of genes in gene set: 1450.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A1	0.0229196	2	GTEx	DepMap	Descartes	41.87	1624.09
COL1A2	0.0209718	3	GTEx	DepMap	Descartes	27.68	1068.65
DCN	0.0000279	4347	GTEx	DepMap	Descartes	5.62	181.84

DC: Transitional DC (curated markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.61e-02
Mean rank of genes in gene set: 1668.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AXL	0.0012899	458	GTEx	DepMap	Descartes	0.84	34.8
KLF4	0.0001402	2879	GTEx	DepMap	Descartes	0.68	41.8

Monocyte precursor: Monocyte precursor (curated markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.35e-02
Mean rank of genes in gene set: 75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	0.0051682	75	GTEx	DepMap	Descartes	2.77	49.22

B cells: Transitional B cells (curated markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.08e-02
Mean rank of genes in gene set: 343
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYO1C	0.0016594	343	GTEx	DepMap	Descartes	0.99	35.69

B-cell lineage: Large pre-B cells (curated markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.53e-02
Mean rank of genes in gene set: 2187
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	0.0006921	873	GTEx	DepMap	Descartes	0.03	1.34
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85

Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.85e-02
Mean rank of genes in gene set: 3736
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A6	0.0061056	61	GTEx	DepMap	Descartes	35.89	10670.18
ACTB	0.0019886	287	GTEx	DepMap	Descartes	41.82	3507.95
FTH1	0.0001118	3161	GTEx	DepMap	Descartes	57.69	8637.32
SRGN	0.0000338	4249	GTEx	DepMap	Descartes	2.24	311.77
TYROBP	-0.0002361	10922	GTEx	DepMap	Descartes	1.11	283.58

B-cell lineage: Small pre-B cells (curated markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.80e-02
Mean rank of genes in gene set: 873
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	0.0006921	873	GTEx	DepMap	Descartes	0.03	1.34

B-cell lineage: Pro-B cells (curated markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.80e-02
Mean rank of genes in gene set: 873
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	0.0006921	873	GTEx	DepMap	Descartes	0.03	1.34

DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.43e-02
Mean rank of genes in gene set: 3395.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP9	0.0009391	652	GTEx	DepMap	Descartes	1.78	82.52
CST3	0.0002086	2279	GTEx	DepMap	Descartes	12.74	787.94
AGRP	-0.0000786	7256	GTEx	DepMap	Descartes	0.01	0.89

T cells: Memory CD4+ cytotoxic T cells (model markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.33e-01
Mean rank of genes in gene set: 2250
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.000213	2250	GTEx	DepMap	Descartes	0.3	68.76

T cells: Follicular helper T cells (model markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.44e-01
Mean rank of genes in gene set: 4352
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HOXB5	0.0006172	969	GTEx	DepMap	Descartes	0.06	6.14
SOCS3	0.0004150	1359	GTEx	DepMap	Descartes	2.25	159.11
CH25H	-0.0000439	6195	GTEx	DepMap	Descartes	0.04	4.94
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52

B cells: Germinal center B cells (curated markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.77e-01
Mean rank of genes in gene set: 3904
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD40	0.0004116	1369	GTEx	DepMap	Descartes	0.46	51.07
POU2AF1	-0.0000512	6439	GTEx	DepMap	Descartes	0.00	0.00

Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.78e-01
Mean rank of genes in gene set: 4605.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VWF	0.0003554	1562	GTEx	DepMap	Descartes	2.03	48.76
JAM2	0.0000278	4352	GTEx	DepMap	Descartes	0.22	12.96
RAMP3	0.0000003	4906	GTEx	DepMap	Descartes	0.50	72.58
MMRN2	-0.0000896	7602	GTEx	DepMap	Descartes	0.20	7.24

T cells: Trm cytotoxic T cells (curated markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.91e-01
Mean rank of genes in gene set: 4032.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA1	0.0007613	811	GTEx	DepMap	Descartes	1.74	31.43
ITGAE	-0.0000785	7254	GTEx	DepMap	Descartes	0.61	26.44

T cells: Tcm/Naive helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.92e-01
Mean rank of genes in gene set: 4700.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TMSB10	0.0016365	347	GTEx	DepMap	Descartes	86.65	34808.85
CTSL	0.0000957	3339	GTEx	DepMap	Descartes	1.45	NA
FCGRT	0.0000148	4610	GTEx	DepMap	Descartes	1.78	139.82
LTB	-0.0002109	10507	GTEx	DepMap	Descartes	0.11	15.60

ETP: ETP (model markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.02e-01
Mean rank of genes in gene set: 4136.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	2.13e-04	2250	GTEx	DepMap	Descartes	0.3	68.76
WDR49	-3.79e-05	6023	GTEx	DepMap	Descartes	0.0	0.00

Macrophages: Kupffer cells (curated markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.15e-01
Mean rank of genes in gene set: 4255.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAM1	0.0010252	592	GTEx	DepMap	Descartes	1.01	53.99
CD5L	-0.0001004	7919	GTEx	DepMap	Descartes	0.00	0.00

Granulocytes: Granulocytes (curated markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.19e-01
Mean rank of genes in gene set: 4649.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC45A3	2.63e-04	1962	GTEx	DepMap	Descartes	0.03	1.92
KIT	-3.60e-05	5967	GTEx	DepMap	Descartes	0.05	1.21
CPA3	-3.78e-05	6020	GTEx	DepMap	Descartes	0.00	0.00

Macrophages: Hofbauer cells (curated markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.19e-01
Mean rank of genes in gene set: 3471
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCIN	8.65e-05	3471	GTEx	DepMap	Descartes	0.07	1.02

Monocytes: Non-classical monocytes (model markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.29e-01
Mean rank of genes in gene set: 4929.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RHOC	0.0023444	235	GTEx	DepMap	Descartes	3.30	290.49
BAG3	0.0003333	1644	GTEx	DepMap	Descartes	0.30	22.28
CUX2	-0.0001078	8131	GTEx	DepMap	Descartes	0.03	0.50
ABI3	-0.0001676	9707	GTEx	DepMap	Descartes	0.15	12.81

ILC: ILC (curated markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.44e-01
Mean rank of genes in gene set: 4824
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A13	0.0069114	46	GTEx	DepMap	Descartes	2.88	292.63
TLE1	-0.0000231	5578	GTEx	DepMap	Descartes	0.30	15.94
AREG	-0.0001334	8848	GTEx	DepMap	Descartes	0.34	70.09

Plasma cells: Plasma cells (model markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.91e-01
Mean rank of genes in gene set: 5275.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
XBP1	0.0002101	2270	GTEx	DepMap	Descartes	1.11	91.06
TGFBR3L	0.0000110	4675	GTEx	DepMap	Descartes	0.02	NA
ST18	-0.0000166	5379	GTEx	DepMap	Descartes	0.02	0.58
MZB1	-0.0001308	8779	GTEx	DepMap	Descartes	0.01	NA

Mast cells: Mast cells (curated markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.08e-01
Mean rank of genes in gene set: 4993
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPSB2	5.11e-05	3966	GTEx	DepMap	Descartes	0.01	0.99
CPA3	-3.78e-05	6020	GTEx	DepMap	Descartes	0.00	0.00

Granulocytes: Granulocytes (model markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.14e-01
Mean rank of genes in gene set: 5036.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC10A5	5.04e-05	3975	GTEx	DepMap	Descartes	0.01	2.51
MAK	-4.07e-05	6098	GTEx	DepMap	Descartes	0.01	1.00

B cells: Follicular B cells (curated markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.26e-01
Mean rank of genes in gene set: 5117.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-2.70e-06	4982	GTEx	DepMap	Descartes	0.01	0.42
CD22	-1.22e-05	5253	GTEx	DepMap	Descartes	0.01	0.31

Granulocytes: Neutrophils (curated markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.30e-01
Mean rank of genes in gene set: 4678
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCN2	1.08e-05	4678	GTEx	DepMap	Descartes	0.01	0.34

Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.50e-01
Mean rank of genes in gene set: 5810.44
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0056978	67	GTEx	DepMap	Descartes	1.01	55.09
OLFML1	0.0010044	607	GTEx	DepMap	Descartes	0.16	15.06
PDGFRA	0.0004745	1212	GTEx	DepMap	Descartes	0.51	19.41
F10	0.0004297	1316	GTEx	DepMap	Descartes	0.08	11.27
ANGPTL1	0.0000864	3473	GTEx	DepMap	Descartes	0.01	1.83
EBF2	-0.0001596	9524	GTEx	DepMap	Descartes	0.27	10.68
NTRK2	-0.0003191	11692	GTEx	DepMap	Descartes	0.19	5.28
SFRP1	-0.0004015	12099	GTEx	DepMap	Descartes	0.32	10.27
SMOC2	-0.0004962	12304	GTEx	DepMap	Descartes	0.62	43.50

B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.55e-01
Mean rank of genes in gene set: 5321.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
YBX3	0.0006806	885	GTEx	DepMap	Descartes	1.78	NA
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26

T cells: Tem/Effector helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.55e-01
Mean rank of genes in gene set: 5499.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB1	0.0042378	100	GTEx	DepMap	Descartes	8.76	465.60
AQP3	-0.0000865	7514	GTEx	DepMap	Descartes	0.06	3.80
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52

ILC: ILC3 (curated markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.66e-01
Mean rank of genes in gene set: 5558
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RORC	4.60e-06	4810	GTEx	DepMap	Descartes	0.01	0.30
IL4I1	-3.39e-05	5897	GTEx	DepMap	Descartes	0.18	15.88
KIT	-3.60e-05	5967	GTEx	DepMap	Descartes	0.05	1.21

Plasma cells: Plasma cells (curated markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.85e-01
Mean rank of genes in gene set: 5524.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
XBP1	0.0002101	2270	GTEx	DepMap	Descartes	1.11	91.06
MZB1	-0.0001308	8779	GTEx	DepMap	Descartes	0.01	NA

HSC/MPP: Early lymphoid/T lymphoid (model markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.02e-01
Mean rank of genes in gene set: 5379
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-1.66e-05	5379	GTEx	DepMap	Descartes	0.02	0.58

T cells: T(agonist) (curated markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.05e-01
Mean rank of genes in gene set: 5773
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MIR155HG	0.0001637	2637	GTEx	DepMap	Descartes	0.09	8.81
SMS	-0.0000703	7014	GTEx	DepMap	Descartes	1.66	162.89
BIRC3	-0.0000919	7668	GTEx	DepMap	Descartes	0.36	9.71

Erythroid: Late erythroid (model markers)
late erythroid cells following early and middle erythroid cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.09e-01
Mean rank of genes in gene set: 5688.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-2.04e-05	5489	GTEx	DepMap	Descartes	0	0
SLC12A3	-3.36e-05	5888	GTEx	DepMap	Descartes	0	0

Cycling cells: Cycling T cells (model markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.14e-01
Mean rank of genes in gene set: 5489
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-2.04e-05	5489	GTEx	DepMap	Descartes	0	0

ILC: ILC3 (model markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.14e-01
Mean rank of genes in gene set: 5489
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-2.04e-05	5489	GTEx	DepMap	Descartes	0	0

Promyelocytes: Promyelocytes (model markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.14e-01
Mean rank of genes in gene set: 5489
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-2.04e-05	5489	GTEx	DepMap	Descartes	0	0

HSC/MPP: CMP (model markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.20e-01
Mean rank of genes in gene set: 5754.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-2.04e-05	5489	GTEx	DepMap	Descartes	0	0
CPA3	-3.78e-05	6020	GTEx	DepMap	Descartes	0	0

Early MK: Early MK (model markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.20e-01
Mean rank of genes in gene set: 5755.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-2.04e-05	5489	GTEx	DepMap	Descartes	0	0
CCDC175	-3.79e-05	6022	GTEx	DepMap	Descartes	0	NA

T cells: Type 1 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.30e-01
Mean rank of genes in gene set: 5989.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0010047	606	GTEx	DepMap	Descartes	4.93	450.99
CEBPB	0.0001921	2413	GTEx	DepMap	Descartes	1.57	148.17
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
PRDM16	-0.0001903	10160	GTEx	DepMap	Descartes	0.02	0.37

pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.44e-01
Mean rank of genes in gene set: 5913
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCDC50	0.0005133	1144	GTEx	DepMap	Descartes	1.00	22.15
IRF7	-0.0002212	10682	GTEx	DepMap	Descartes	0.48	41.96

T cells: Regulatory T cells (curated markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.63e-01
Mean rank of genes in gene set: 5935
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-3.49e-05	5935	GTEx	DepMap	Descartes	0	0

ETP: ETP (curated markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.66e-01
Mean rank of genes in gene set: 6055
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	-9.90e-06	5182	GTEx	DepMap	Descartes	0.63	15.16
SPINK2	-6.82e-05	6928	GTEx	DepMap	Descartes	0.00	0.00

Mast cells: Mast cells (model markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.72e-01
Mean rank of genes in gene set: 6020
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	-3.78e-05	6020	GTEx	DepMap	Descartes	0	0

DC: Migratory DCs (model markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.72e-01
Mean rank of genes in gene set: 6023
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-3.79e-05	6023	GTEx	DepMap	Descartes	0	0

T cells: Follicular helper T cells (curated markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.74e-01
Mean rank of genes in gene set: 6108.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-2.70e-06	4982	GTEx	DepMap	Descartes	0.01	0.42
PDCD1	-7.76e-05	7235	GTEx	DepMap	Descartes	0.00	0.00

B cells: Germinal center B cells (model markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.82e-01
Mean rank of genes in gene set: 6159
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AICDA	-8.00e-06	5115	GTEx	DepMap	Descartes	0	0
BMP3	-7.64e-05	7203	GTEx	DepMap	Descartes	0	0

HSC/MPP: HSC/MPP (curated markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.82e-01
Mean rank of genes in gene set: 6181.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	-9.90e-06	5182	GTEx	DepMap	Descartes	0.63	15.16
CRHBP	-5.11e-05	6434	GTEx	DepMap	Descartes	0.03	2.47
SPINK2	-6.82e-05	6928	GTEx	DepMap	Descartes	0.00	0.00

Double-negative thymocytes: Double-negative thymocytes (model markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.00e-01
Mean rank of genes in gene set: 6276.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDLIM1	0.0023696	232	GTEx	DepMap	Descartes	2.78	306.93
MFAP4	0.0002654	1945	GTEx	DepMap	Descartes	0.12	13.51
FXYD2	-0.0000673	6903	GTEx	DepMap	Descartes	0.01	0.20
MZB1	-0.0001308	8779	GTEx	DepMap	Descartes	0.01	NA
SELL	-0.0001485	9262	GTEx	DepMap	Descartes	0.04	3.07
CD7	-0.0002128	10537	GTEx	DepMap	Descartes	0.09	6.61

Macrophages: Kupffer cells (model markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.11e-01
Mean rank of genes in gene set: 6324.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0002130	2250	GTEx	DepMap	Descartes	0.30	68.76
EGR2	0.0000225	4466	GTEx	DepMap	Descartes	0.30	22.76
CD5L	-0.0001004	7919	GTEx	DepMap	Descartes	0.00	0.00
ARRDC3	-0.0002201	10664	GTEx	DepMap	Descartes	0.53	23.39

ILC precursor: ILC precursor (model markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.12e-01
Mean rank of genes in gene set: 6340.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDZK1	0.0000673	3750	GTEx	DepMap	Descartes	0.01	0.59
HPN	-0.0000435	6181	GTEx	DepMap	Descartes	0.00	0.00
HUNK	-0.0001427	9090	GTEx	DepMap	Descartes	0.05	0.88

T cells: Type 1 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.26e-01
Mean rank of genes in gene set: 6439.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TBX21	-3.20e-06	4996	GTEx	DepMap	Descartes	0.01	0.16
CCL5	-9.92e-05	7883	GTEx	DepMap	Descartes	0.15	50.50

Mono-mac: Mono-mac (curated markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.31e-01
Mean rank of genes in gene set: 6475
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HMOX1	0.0002515	2028	GTEx	DepMap	Descartes	0.61	69.63
TYROBP	-0.0002361	10922	GTEx	DepMap	Descartes	1.11	283.58

B-cell lineage: Small pre-B cells (model markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.34e-01
Mean rank of genes in gene set: 6427.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLDC2	-0.0000061	5063	GTEx	DepMap	Descartes	0.00	NA
AICDA	-0.0000080	5115	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0000204	5489	GTEx	DepMap	Descartes	0.00	0.00
CD79B	-0.0001834	10044	GTEx	DepMap	Descartes	0.06	5.12

DC: DC1 (curated markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.40e-01
Mean rank of genes in gene set: 6530.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BATF3	0.0009417	650	GTEx	DepMap	Descartes	0.26	19.55
CADM1	-0.0006189	12411	GTEx	DepMap	Descartes	0.76	8.92

DC: Migratory DCs (curated markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.56e-01
Mean rank of genes in gene set: 6636
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EBI3	0.0000085	4728	GTEx	DepMap	Descartes	0.06	10.81
CCR7	-0.0001223	8544	GTEx	DepMap	Descartes	0.20	13.77

ILC: CD16- NK cells (curated markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.59e-01
Mean rank of genes in gene set: 6808
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD160	-6.38e-05	6808	GTEx	DepMap	Descartes	0	0

Monocytes: Classical monocytes (curated markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.70e-01
Mean rank of genes in gene set: 6914
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD14	-6.77e-05	6914	GTEx	DepMap	Descartes	0.38	41.75

Monocyte precursor: Monocyte precursor (model markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.74e-01
Mean rank of genes in gene set: 6755
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.0000166	5379	GTEx	DepMap	Descartes	0.02	0.58
CUX2	-0.0001078	8131	GTEx	DepMap	Descartes	0.03	0.50

B cells: B cells (curated markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.77e-01
Mean rank of genes in gene set: 6773.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-4.94e-05	6373	GTEx	DepMap	Descartes	0.01	0.77
CD79A	-7.55e-05	7174	GTEx	DepMap	Descartes	0.05	7.87

Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.87e-01
Mean rank of genes in gene set: 6673.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FTH1	0.0001118	3161	GTEx	DepMap	Descartes	57.69	8637.32
APOE	0.0000114	4668	GTEx	DepMap	Descartes	11.51	2029.32
CD5L	-0.0001004	7919	GTEx	DepMap	Descartes	0.00	0.00
APOC1	-0.0002387	10946	GTEx	DepMap	Descartes	2.80	719.42

pDC: pDC (curated markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.96e-01
Mean rank of genes in gene set: 7152
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLD4	-7.47e-05	7152	GTEx	DepMap	Descartes	0.05	4.17

ILC: ILC1 (curated markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.06e-01
Mean rank of genes in gene set: 7250
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF3	-7.83e-05	7250	GTEx	DepMap	Descartes	0.01	0.14

pDC precursor: pDC precursor (model markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.07e-01
Mean rank of genes in gene set: 7256
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	-7.86e-05	7256	GTEx	DepMap	Descartes	0.01	0.89

Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.11e-01
Mean rank of genes in gene set: 6863
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0025399	211	GTEx	DepMap	Descartes	8.12	77.81
SAT1	-0.0001566	9456	GTEx	DepMap	Descartes	6.15	997.17
TYROBP	-0.0002361	10922	GTEx	DepMap	Descartes	1.11	283.58

T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.49e-01
Mean rank of genes in gene set: 6896.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TMSB10	0.0016365	347	GTEx	DepMap	Descartes	86.65	34808.85
CD44	0.0004413	1289	GTEx	DepMap	Descartes	1.45	52.53
ITM2A	-0.0001233	8575	GTEx	DepMap	Descartes	0.07	13.76
SATB1	-0.0003281	11763	GTEx	DepMap	Descartes	0.41	7.34
MALAT1	-0.0008571	12507	GTEx	DepMap	Descartes	220.84	5155.17

Cycling cells: Cycling B cells (curated markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.51e-01
Mean rank of genes in gene set: 7084.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
CD19	-0.0000494	6373	GTEx	DepMap	Descartes	0.01	0.77
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

HSC/MPP: ELP (curated markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.62e-01
Mean rank of genes in gene set: 7344
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RUNX2	0.0000377	4181	GTEx	DepMap	Descartes	0.07	3.33
LTB	-0.0002109	10507	GTEx	DepMap	Descartes	0.11	15.60

T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.63e-01
Mean rank of genes in gene set: 7355.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
INPP5J	-0.0000072	5097	GTEx	DepMap	Descartes	0.01	0.24
PANX2	-0.0001638	9614	GTEx	DepMap	Descartes	0.06	1.73

T cells: Tem/Effector helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.68e-01
Mean rank of genes in gene set: 6918.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0010047	606	GTEx	DepMap	Descartes	4.93	450.99
DONSON	0.0003319	1654	GTEx	DepMap	Descartes	0.09	6.47
AQP3	-0.0000865	7514	GTEx	DepMap	Descartes	0.06	3.80
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
LTB	-0.0002109	10507	GTEx	DepMap	Descartes	0.11	15.60
S100A4	-0.0005266	12343	GTEx	DepMap	Descartes	6.83	1377.82

ILC: Transitional NK (curated markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.71e-01
Mean rank of genes in gene set: 7883
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-9.92e-05	7883	GTEx	DepMap	Descartes	0.15	50.5

T cells: gamma-delta T cells (curated markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.71e-01
Mean rank of genes in gene set: 7883
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-9.92e-05	7883	GTEx	DepMap	Descartes	0.15	50.5

Cycling cells: Cycling DCs (curated markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.75e-01
Mean rank of genes in gene set: 7440.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.75e-01
Mean rank of genes in gene set: 7440.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.75e-01
Mean rank of genes in gene set: 7440.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

Cycling cells: Cycling NK cells (curated markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.75e-01
Mean rank of genes in gene set: 7440.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

Cycling cells: Cycling T cells (curated markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.75e-01
Mean rank of genes in gene set: 7440.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	0.0000848	3501	GTEx	DepMap	Descartes	0.49	6.85
TOP2A	-0.0002761	11380	GTEx	DepMap	Descartes	0.71	18.74

T cells: Type 17 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.84e-01
Mean rank of genes in gene set: 7278
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0010047	606	GTEx	DepMap	Descartes	4.93	450.99
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
S100A4	-0.0005266	12343	GTEx	DepMap	Descartes	6.83	1377.82

Early MK: Early MK (curated markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.85e-01
Mean rank of genes in gene set: 8022
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	-0.0001041	8022	GTEx	DepMap	Descartes	0.09	11.01

Megakaryocyte precursor: Megakaryocyte precursor (model markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.86e-01
Mean rank of genes in gene set: 7517.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC10A5	0.0000504	3975	GTEx	DepMap	Descartes	0.01	2.51
ADRA2A	-0.0002463	11060	GTEx	DepMap	Descartes	0.03	0.80

HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.96e-01
Mean rank of genes in gene set: 8131
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0001078	8131	GTEx	DepMap	Descartes	0.03	0.5

HSC/MPP: Early lymphoid/T lymphoid (curated markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.19e-01
Mean rank of genes in gene set: 7760
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ETS1	0.0001256	3017	GTEx	DepMap	Descartes	0.87	32.77
GATA3	-0.0008315	12503	GTEx	DepMap	Descartes	1.12	44.20

T cells: MAIT cells (curated markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.19e-01
Mean rank of genes in gene set: 7763.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC4A10	-0.0000586	6642	GTEx	DepMap	Descartes	0.01	0.07
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52

ILC: ILC2 (model markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.22e-01
Mean rank of genes in gene set: 8411
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL17RB	-0.0001173	8411	GTEx	DepMap	Descartes	0	0

Cycling cells: Cycling B cells (model markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.31e-01
Mean rank of genes in gene set: 7560.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000204	5489	GTEx	DepMap	Descartes	0.00	0.00
RGS13	-0.0000278	5734	GTEx	DepMap	Descartes	0.00	0.00
GRIN1	-0.0002853	11458	GTEx	DepMap	Descartes	0.14	3.39

B-cell lineage: Large pre-B cells (model markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.31e-01
Mean rank of genes in gene set: 8507
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0001208	8507	GTEx	DepMap	Descartes	0.01	1.03

DC: DC1 (model markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.31e-01
Mean rank of genes in gene set: 8507
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0001208	8507	GTEx	DepMap	Descartes	0.01	1.03

Erythrocytes: Erythrocytes (model markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.31e-01
Mean rank of genes in gene set: 8507
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0001208	8507	GTEx	DepMap	Descartes	0.01	1.03

DC: DC3 (model markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.32e-01
Mean rank of genes in gene set: 7861
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0000764	7203	GTEx	DepMap	Descartes	0.00	0.00
OGDHL	-0.0001212	8519	GTEx	DepMap	Descartes	0.03	0.69

DC precursor: DC precursor (model markers)
dendritic cell precursors that differentiate into dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.32e-01
Mean rank of genes in gene set: 8519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	-0.0001212	8519	GTEx	DepMap	Descartes	0.03	0.69

T cells: Tem/Temra cytotoxic T cells (model markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.57e-01
Mean rank of genes in gene set: 8799
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001315	8799	GTEx	DepMap	Descartes	0.25	7.98

Double-negative thymocytes: Double-negative thymocytes (curated markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.65e-01
Mean rank of genes in gene set: 8127.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FXYD2	-0.0000673	6903	GTEx	DepMap	Descartes	0.01	0.20
HES1	-0.0001517	9352	GTEx	DepMap	Descartes	1.30	150.64

ILC: NK cells (model markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.67e-01
Mean rank of genes in gene set: 7272.14
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HMOX1	0.0002515	2028	GTEx	DepMap	Descartes	0.61	69.63
IGFBP4	0.0002178	2223	GTEx	DepMap	Descartes	5.83	486.43
CST3	0.0002086	2279	GTEx	DepMap	Descartes	12.74	787.94
SPINK2	-0.0000682	6928	GTEx	DepMap	Descartes	0.00	0.00
KLHL23	-0.0006664	12438	GTEx	DepMap	Descartes	0.66	21.68
STMN1	-0.0008231	12502	GTEx	DepMap	Descartes	5.54	284.85
MALAT1	-0.0008571	12507	GTEx	DepMap	Descartes	220.84	5155.17

ILC: CD16+ NK cells (model markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.77e-01
Mean rank of genes in gene set: 7510.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IGFBP7	0.0004109	1373	GTEx	DepMap	Descartes	54.32	7379.00
ADAMTS1	-0.0000687	6947	GTEx	DepMap	Descartes	0.81	25.88
PRSS57	-0.0000847	7438	GTEx	DepMap	Descartes	0.00	0.00
FCER1G	-0.0002331	10874	GTEx	DepMap	Descartes	0.64	180.79
TYROBP	-0.0002361	10922	GTEx	DepMap	Descartes	1.11	283.58

Megakaryocytes/platelets: Megakaryocytes/platelets (curated markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.90e-01
Mean rank of genes in gene set: 8337.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	-0.0001041	8022	GTEx	DepMap	Descartes	0.09	11.01
ITGA2B	-0.0001265	8653	GTEx	DepMap	Descartes	0.01	0.12

T cells: NKT cells (curated markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.92e-01
Mean rank of genes in gene set: 9223
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23

T cells: Tem/Trm cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.13e-01
Mean rank of genes in gene set: 8553
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23

Cycling cells: Cycling DCs (model markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.14e-01
Mean rank of genes in gene set: 9509
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP12	-0.0001586	9509	GTEx	DepMap	Descartes	0.01	0.83

ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.17e-01
Mean rank of genes in gene set: 8169
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPN	-0.0000435	6181	GTEx	DepMap	Descartes	0.00	0.00
SCN1B	-0.0001040	8020	GTEx	DepMap	Descartes	0.04	1.83
LST1	-0.0001985	10306	GTEx	DepMap	Descartes	0.28	34.93

Macrophages: Hofbauer cells (model markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.22e-01
Mean rank of genes in gene set: 9614
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PANX2	-0.0001638	9614	GTEx	DepMap	Descartes	0.06	1.73

pDC: pDC (model markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.22e-01
Mean rank of genes in gene set: 8636.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	-0.0001212	8519	GTEx	DepMap	Descartes	0.03	0.69
TRIM71	-0.0001300	8754	GTEx	DepMap	Descartes	0.00	0.00

Macrophages: Kidney-resident macrophages (curated markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.32e-01
Mean rank of genes in gene set: 9758
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26

T cells: Tcm/Naive cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.45e-01
Mean rank of genes in gene set: 8873
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
B2M	-0.0001214	8523	GTEx	DepMap	Descartes	76.91	6472.56
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23

T cells: Tem/Trm cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.45e-01
Mean rank of genes in gene set: 8396.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
CST7	-0.0001064	8084	GTEx	DepMap	Descartes	0.07	19.73
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23

Erythroid: Early erythroid (model markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.47e-01
Mean rank of genes in gene set: 8131.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000204	5489	GTEx	DepMap	Descartes	0.00	0.00
PRSS57	-0.0000847	7438	GTEx	DepMap	Descartes	0.00	0.00
FAM178B	-0.0001264	8652	GTEx	DepMap	Descartes	0.01	0.20
APOC1	-0.0002387	10946	GTEx	DepMap	Descartes	2.80	719.42

T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.53e-01
Mean rank of genes in gene set: 7711.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COTL1	0.0003310	1656	GTEx	DepMap	Descartes	2.14	69.26
SMS	-0.0000703	7014	GTEx	DepMap	Descartes	1.66	162.89
BIRC3	-0.0000919	7668	GTEx	DepMap	Descartes	0.36	9.71
B2M	-0.0001214	8523	GTEx	DepMap	Descartes	76.91	6472.56
ITM2A	-0.0001233	8575	GTEx	DepMap	Descartes	0.07	13.76
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26
PTPRC	-0.0002277	10787	GTEx	DepMap	Descartes	0.14	4.68

B cells: Memory B cells (curated markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.53e-01
Mean rank of genes in gene set: 10077
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD27	-0.0001855	10077	GTEx	DepMap	Descartes	0.02	5.35

MNP: MNP (curated markers)
mononuclear phagocytes including dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.55e-01
Mean rank of genes in gene set: 10101
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FGL2	-0.0001868	10101	GTEx	DepMap	Descartes	0.21	8.54

T cells: Tem/Effector helper T cells PD1+ (curated markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.63e-01
Mean rank of genes in gene set: 9078
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0000776	7235	GTEx	DepMap	Descartes	0.00	0.0
CD4	-0.0002358	10921	GTEx	DepMap	Descartes	0.14	8.2

ILC: CD16- NK cells (model markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.63e-01
Mean rank of genes in gene set: 7775.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GSTP1	0.0008961	687	GTEx	DepMap	Descartes	7.39	816.98
CLIC3	0.0000107	4681	GTEx	DepMap	Descartes	0.05	13.60
LDB2	-0.0001028	7985	GTEx	DepMap	Descartes	0.27	19.69
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
CXCL3	-0.0002043	10394	GTEx	DepMap	Descartes	0.80	67.66
FCER1G	-0.0002331	10874	GTEx	DepMap	Descartes	0.64	180.79
TYROBP	-0.0002361	10922	GTEx	DepMap	Descartes	1.11	283.58

T cells: Trm cytotoxic T cells (model markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.70e-01
Mean rank of genes in gene set: 8635
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0000992	7883	GTEx	DepMap	Descartes	0.15	50.50
IL7R	-0.0001315	8799	GTEx	DepMap	Descartes	0.25	7.98
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23

HSC/MPP: HSC/MPP (model markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.73e-01
Mean rank of genes in gene set: 9193
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPINK2	-0.0000682	6928	GTEx	DepMap	Descartes	0.00	0.00
GRIN1	-0.0002853	11458	GTEx	DepMap	Descartes	0.14	3.39

T cells: Treg(diff) (curated markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.75e-01
Mean rank of genes in gene set: 8678
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF4	-0.0000835	7413	GTEx	DepMap	Descartes	0.09	2.69
CCR7	-0.0001223	8544	GTEx	DepMap	Descartes	0.20	13.77
CD27	-0.0001855	10077	GTEx	DepMap	Descartes	0.02	5.35

Monocytes: Classical monocytes (model markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.76e-01
Mean rank of genes in gene set: 8691.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0000204	5489	GTEx	DepMap	Descartes	0.00	0.00
CST7	-0.0001064	8084	GTEx	DepMap	Descartes	0.07	19.73
EEF1A1	-0.0008173	12501	GTEx	DepMap	Descartes	72.99	2517.28

DC: DC (model markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.81e-01
Mean rank of genes in gene set: 10558
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0002142	10558	GTEx	DepMap	Descartes	0.53	32.4

Mono-mac: Mono-mac (model markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.82e-01
Mean rank of genes in gene set: 8425
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FTH1	0.0001118	3161	GTEx	DepMap	Descartes	57.69	8637.32
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
SAT1	-0.0001566	9456	GTEx	DepMap	Descartes	6.15	997.17
S100A2	-0.0004388	12198	GTEx	DepMap	Descartes	0.18	26.97

T cells: Regulatory T cells (model markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.94e-01
Mean rank of genes in gene set: 8531.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SRGN	0.0000338	4249	GTEx	DepMap	Descartes	2.24	311.77
TIGIT	-0.0000979	7844	GTEx	DepMap	Descartes	0.01	0.27
RGS1	-0.0002142	10558	GTEx	DepMap	Descartes	0.53	32.40
RTKN2	-0.0002878	11475	GTEx	DepMap	Descartes	0.10	2.08

B cells: Memory B cells (model markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.00e-01
Mean rank of genes in gene set: 9555
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HES1	-0.0001517	9352	GTEx	DepMap	Descartes	1.30	150.64
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26

T cells: Memory CD4+ cytotoxic T cells (curated markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.04e-01
Mean rank of genes in gene set: 9621
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL10	-0.0001141	8321	GTEx	DepMap	Descartes	0.03	2.09
CD4	-0.0002358	10921	GTEx	DepMap	Descartes	0.14	8.20

T cells: Tcm/Naive cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.05e-01
Mean rank of genes in gene set: 9009.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCR7	-0.0001223	8544	GTEx	DepMap	Descartes	0.20	13.77
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23
SELL	-0.0001485	9262	GTEx	DepMap	Descartes	0.04	3.07

T cells: MAIT cells (model markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.09e-01
Mean rank of genes in gene set: 8691.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0000764	7203	GTEx	DepMap	Descartes	0.00	0.00
IL7R	-0.0001315	8799	GTEx	DepMap	Descartes	0.25	7.98
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
KLRG1	-0.0001750	9879	GTEx	DepMap	Descartes	0.04	6.95

Macrophages: Macrophages (curated markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.10e-01
Mean rank of genes in gene set: 11129
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD68	-0.0002525	11129	GTEx	DepMap	Descartes	0.52	48.95

Megakaryocyte precursor: Megakaryocyte precursor (curated markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-01
Mean rank of genes in gene set: 9818.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRSS57	-0.0000847	7438	GTEx	DepMap	Descartes	0.0	0.00
GATA2	-0.0004392	12199	GTEx	DepMap	Descartes	0.2	9.37

T cells: CD8a/a (curated markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-01
Mean rank of genes in gene set: 9830.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0000776	7235	GTEx	DepMap	Descartes	0.00	0.00
GNG4	-0.0006459	12426	GTEx	DepMap	Descartes	0.36	8.58

B-cell lineage: Pre-pro-B cells (curated markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.21e-01
Mean rank of genes in gene set: 9887.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001315	8799	GTEx	DepMap	Descartes	0.25	7.98
ZCCHC7	-0.0002411	10976	GTEx	DepMap	Descartes	0.19	11.59

B cells: Follicular B cells (model markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.21e-01
Mean rank of genes in gene set: 9895.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VPREB3	-0.0001461	9188	GTEx	DepMap	Descartes	0.00	0.00
CD83	-0.0002169	10603	GTEx	DepMap	Descartes	0.69	44.63

Epithelial cells: Epithelial cells (model markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.23e-01
Mean rank of genes in gene set: 9932.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDH3	-0.0000883	7564	GTEx	DepMap	Descartes	0.01	0.32
WFDC2	-0.0004945	12301	GTEx	DepMap	Descartes	0.20	39.64

Double-positive thymocytes: Double-positive thymocytes (curated markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.24e-01
Mean rank of genes in gene set: 9945.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23
SMPD3	-0.0002203	10668	GTEx	DepMap	Descartes	0.03	1.17

T cells: Type 17 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.25e-01
Mean rank of genes in gene set: 9965.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001315	8799	GTEx	DepMap	Descartes	0.25	7.98
ZBTB16	-0.0002526	11132	GTEx	DepMap	Descartes	0.03	0.22

Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.27e-01
Mean rank of genes in gene set: 9991
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KL	-0.0001214	8524	GTEx	DepMap	Descartes	0.01	0.08
GRIN1	-0.0002853	11458	GTEx	DepMap	Descartes	0.14	3.39

T cells: CD8a/b(entry) (curated markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.35e-01
Mean rank of genes in gene set: 11763
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SATB1	-0.0003281	11763	GTEx	DepMap	Descartes	0.41	7.34

T cells: gamma-delta T cells (model markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.38e-01
Mean rank of genes in gene set: 9485
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRC2	-0.0000488	6354	GTEx	DepMap	Descartes	0.00	0.00
KCNK10	-0.0002189	10643	GTEx	DepMap	Descartes	0.02	0.30
GRIN1	-0.0002853	11458	GTEx	DepMap	Descartes	0.14	3.39

Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.43e-01
Mean rank of genes in gene set: 9572
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CLDN5	-0.0000110	5211	GTEx	DepMap	Descartes	0.86	54.97
PLVAP	-0.0002394	10959	GTEx	DepMap	Descartes	0.76	53.67
SPARCL1	-0.0020692	12546	GTEx	DepMap	Descartes	3.93	242.12

T cells: Tcm/Naive helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.43e-01
Mean rank of genes in gene set: 9575.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCR7	-0.0001223	8544	GTEx	DepMap	Descartes	0.20	13.77
SELL	-0.0001485	9262	GTEx	DepMap	Descartes	0.04	3.07
CD4	-0.0002358	10921	GTEx	DepMap	Descartes	0.14	8.20

HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.47e-01
Mean rank of genes in gene set: 10426
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	-0.0001265	8653	GTEx	DepMap	Descartes	0.01	0.12
GATA2	-0.0004392	12199	GTEx	DepMap	Descartes	0.20	9.37

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (curated markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.49e-01
Mean rank of genes in gene set: 12199
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GATA2	-0.0004392	12199	GTEx	DepMap	Descartes	0.2	9.37

Epithelial cells: Epithelial cells (curated markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.49e-01
Mean rank of genes in gene set: 12206
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT17	-0.0004417	12206	GTEx	DepMap	Descartes	0.15	15.81

ILC: Transitional NK (model markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 9305.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	-0.0000786	7256	GTEx	DepMap	Descartes	0.01	0.89
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
PRDM16	-0.0001903	10160	GTEx	DepMap	Descartes	0.02	0.37
TYROBP	-0.0002361	10922	GTEx	DepMap	Descartes	1.11	283.58

ILC: ILC2 (curated markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 9792
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPGDS	-0.0000697	6994	GTEx	DepMap	Descartes	0.01	0.44
KLRG1	-0.0001750	9879	GTEx	DepMap	Descartes	0.04	6.95
GATA3	-0.0008315	12503	GTEx	DepMap	Descartes	1.12	44.20

B cells: Transitional B cells (model markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 12383
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GNG3	-0.0005646	12383	GTEx	DepMap	Descartes	0.44	47.54

B cells: B cells (model markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.55e-01
Mean rank of genes in gene set: 9813
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-0.0000755	7174	GTEx	DepMap	Descartes	0.05	7.87
CD74	-0.0001697	9758	GTEx	DepMap	Descartes	5.24	311.26
MALAT1	-0.0008571	12507	GTEx	DepMap	Descartes	220.84	5155.17

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 12491
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CKB	-0.0007853	12491	GTEx	DepMap	Descartes	2.3	223.94

T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.62e-01
Mean rank of genes in gene set: 8709
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NUCB2	0.0008986	685	GTEx	DepMap	Descartes	1.10	57.26
CTSW	-0.0001246	8606	GTEx	DepMap	Descartes	0.01	1.12
CD8A	-0.0001472	9223	GTEx	DepMap	Descartes	0.01	0.23
PRKCH	-0.0001679	9713	GTEx	DepMap	Descartes	0.11	5.86
CD27	-0.0001855	10077	GTEx	DepMap	Descartes	0.02	5.35
LEF1	-0.0001899	10152	GTEx	DepMap	Descartes	0.13	9.07
MALAT1	-0.0008571	12507	GTEx	DepMap	Descartes	220.84	5155.17

ILC: ILC (model markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.62e-01
Mean rank of genes in gene set: 9497.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001315	8799	GTEx	DepMap	Descartes	0.25	7.98
AREG	-0.0001334	8848	GTEx	DepMap	Descartes	0.34	70.09
KLRB1	-0.0001349	8885	GTEx	DepMap	Descartes	0.03	2.52
GRIN1	-0.0002853	11458	GTEx	DepMap	Descartes	0.14	3.39

Erythroid: Early erythroid (curated markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.69e-01
Mean rank of genes in gene set: 10167.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TESPA1	-0.0000818	7358	GTEx	DepMap	Descartes	0.01	NA
APOC1	-0.0002387	10946	GTEx	DepMap	Descartes	2.80	719.42
GATA2	-0.0004392	12199	GTEx	DepMap	Descartes	0.20	9.37

Double-positive thymocytes: Double-positive thymocytes (model markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 9113.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SH3TC1	-0.0000470	6291	GTEx	DepMap	Descartes	0.09	2.28
RAG2	-0.0000511	6433	GTEx	DepMap	Descartes	0.00	0.00
ARPP21	-0.0001371	8946	GTEx	DepMap	Descartes	0.02	0.91
SMPD3	-0.0002203	10668	GTEx	DepMap	Descartes	0.03	1.17
ELOVL4	-0.0002463	11059	GTEx	DepMap	Descartes	0.11	4.57
CD52	-0.0002661	11282	GTEx	DepMap	Descartes	0.22	74.69

Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-01
Mean rank of genes in gene set: 11907
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KCNH2	-0.0002710	11335	GTEx	DepMap	Descartes	0.05	0.92
PRDX2	-0.0007437	12479	GTEx	DepMap	Descartes	3.08	266.88

T cells: NKT cells (model markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 11069.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	-0.0001903	10160	GTEx	DepMap	Descartes	0.02	0.37
CD52	-0.0002661	11282	GTEx	DepMap	Descartes	0.22	74.69
ITM2C	-0.0003284	11766	GTEx	DepMap	Descartes	1.01	115.28

T cells: Treg(diff) (model markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 11353.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0002142	10558	GTEx	DepMap	Descartes	0.53	32.40
PTPRC	-0.0002277	10787	GTEx	DepMap	Descartes	0.14	4.68
TSC22D3	-0.0003238	11726	GTEx	DepMap	Descartes	0.78	69.85
S100A4	-0.0005266	12343	GTEx	DepMap	Descartes	6.83	1377.82

B cells: Naive B cells (curated markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
DC: DC (curated markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
DC: DC2 (curated markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
DC: DC3 (curated markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
DC precursor: DC precursor (curated markers)
dendritic cell precursors that differentiate into dendritic cells:
Erythrocytes: Erythrocytes (curated markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Erythroid: Late erythroid (curated markers)
late erythroid cells following early and middle erythroid cells:
HSC/MPP: CMP (curated markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
HSC/MPP: GMP (curated markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: Neutrophil-myeloid progenitor (curated markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
ILC: CD16+ NK cells (curated markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
ILC: NK cells (curated markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Monocytes: Non-classical monocytes (curated markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Monocytes: Monocytes (curated markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Myelocytes: Myelocytes (curated markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Promyelocytes: Promyelocytes (curated markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
T cells: Tem/Temra cytotoxic T cells (curated markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
B-cell lineage: Pre-pro-B cells (model markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
B-cell lineage: Pro-B cells (model markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Cycling cells: Cycling gamma-delta T cells (model markers)
proliferating gamma-delta (γδ) T lymphocytes:
Cycling cells: Cycling monocytes (model markers)
proliferating monocytes:
DC: Transitional DC (model markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Erythroid: Mid erythroid (model markers)
middle erythroid cells in fetal liver:
Granulocytes: Neutrophils (model markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
HSC/MPP: ELP (model markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
HSC/MPP: GMP (model markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: MEMP (model markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
ILC: ILC1 (model markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Macrophages: Kidney-resident macrophages (model markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Megakaryocytes/platelets: Megakaryocytes/platelets (model markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
MNP: MNP (model markers)
mononuclear phagocytes including dendritic cells: