Program: 19. Neuroblastoma #5.

Program: 19. Neuroblastoma #5.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 NYAP2 0.0145149 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 GTEx DepMap Descartes 6.94 598.45
2 FOXC1 0.0130890 forkhead box C1 GTEx DepMap Descartes 1.49 148.54
3 PRKCA 0.0094945 protein kinase C alpha GTEx DepMap Descartes 1.29 58.45
4 MAOA 0.0092975 monoamine oxidase A GTEx DepMap Descartes 2.64 186.89
5 ACTG1 0.0089856 actin gamma 1 GTEx DepMap Descartes 45.53 6630.78
6 TBX2 0.0084462 T-box transcription factor 2 GTEx DepMap Descartes 1.51 105.91
7 CHRM3 0.0084036 cholinergic receptor muscarinic 3 GTEx DepMap Descartes 0.63 29.46
8 PSD3 0.0083008 pleckstrin and Sec7 domain containing 3 GTEx DepMap Descartes 1.10 35.36
9 ISLR2 0.0082124 immunoglobulin superfamily containing leucine rich repeat 2 GTEx DepMap Descartes 0.37 31.79
10 KIF21A 0.0081864 kinesin family member 21A GTEx DepMap Descartes 3.78 198.79
11 SLIT3 0.0079606 slit guidance ligand 3 GTEx DepMap Descartes 1.18 46.66
12 MARCH11 0.0079568 NA GTEx DepMap Descartes 3.10 NA
13 NFIB 0.0078921 nuclear factor I B GTEx DepMap Descartes 1.72 66.74
14 PAFAH1B3 0.0078839 platelet activating factor acetylhydrolase 1b catalytic subunit 3 GTEx DepMap Descartes 4.19 1297.63
15 GMDS 0.0078207 GDP-mannose 4,6-dehydratase GTEx DepMap Descartes 0.60 139.44
16 KHDRBS3 0.0075898 KH RNA binding domain containing, signal transduction associated 3 GTEx DepMap Descartes 1.43 96.69
17 NEFL 0.0075750 neurofilament light chain GTEx DepMap Descartes 1.93 179.74
18 PRMT1 0.0074512 protein arginine methyltransferase 1 GTEx DepMap Descartes 3.23 648.13
19 PRDX2 0.0073926 peroxiredoxin 2 GTEx DepMap Descartes 6.92 1330.39
20 MEIS3 0.0072297 Meis homeobox 3 GTEx DepMap Descartes 1.16 204.65
21 UBE2S 0.0071373 ubiquitin conjugating enzyme E2 S GTEx DepMap Descartes 6.98 924.69
22 ERBB4 0.0070309 erb-b2 receptor tyrosine kinase 4 GTEx DepMap Descartes 0.25 9.41
23 BASP1 0.0070053 brain abundant membrane attached signal protein 1 GTEx DepMap Descartes 9.00 1720.93
24 H1FX 0.0069797 NA GTEx DepMap Descartes 5.81 NA
25 MSRB2 0.0069130 methionine sulfoxide reductase B2 GTEx DepMap Descartes 1.54 320.20
26 DCX 0.0069085 doublecortin GTEx DepMap Descartes 1.95 71.98
27 ETV1 0.0068824 ETS variant transcription factor 1 GTEx DepMap Descartes 0.79 43.89
28 SLITRK4 0.0068564 SLIT and NTRK like family member 4 GTEx DepMap Descartes 0.39 16.42
29 KLHL13 0.0065797 kelch like family member 13 GTEx DepMap Descartes 0.75 52.35
30 PCSK1N 0.0065333 proprotein convertase subtilisin/kexin type 1 inhibitor GTEx DepMap Descartes 6.68 2378.48
31 C1QL1 0.0065047 complement C1q like 1 GTEx DepMap Descartes 1.54 398.56
32 CDC42EP3 0.0064864 CDC42 effector protein 3 GTEx DepMap Descartes 1.11 75.47
33 FEZ1 0.0064268 fasciculation and elongation protein zeta 1 GTEx DepMap Descartes 1.22 89.03
34 ELAVL3 0.0064217 ELAV like RNA binding protein 3 GTEx DepMap Descartes 2.55 176.67
35 ISL1 0.0063018 ISL LIM homeobox 1 GTEx DepMap Descartes 2.67 403.87
36 LDHB 0.0062519 lactate dehydrogenase B GTEx DepMap Descartes 7.99 1650.34
37 NEFM 0.0062099 neurofilament medium chain GTEx DepMap Descartes 1.94 194.84
38 PPP1R14B 0.0061856 protein phosphatase 1 regulatory inhibitor subunit 14B GTEx DepMap Descartes 4.34 1428.45
39 GATA3 0.0061806 GATA binding protein 3 GTEx DepMap Descartes 3.80 436.39
40 PDGFRA 0.0061750 platelet derived growth factor receptor alpha GTEx DepMap Descartes 0.50 26.80
41 CKB 0.0061598 creatine kinase B GTEx DepMap Descartes 6.12 1414.90
42 GNAS 0.0060772 GNAS complex locus GTEx DepMap Descartes 21.52 1832.89
43 NDN 0.0060316 necdin, MAGE family member GTEx DepMap Descartes 1.17 216.55
44 PPIA 0.0059160 peptidylprolyl isomerase A GTEx DepMap Descartes 12.28 1791.00
45 BAMBI 0.0058510 BMP and activin membrane bound inhibitor GTEx DepMap Descartes 0.40 86.49
46 PHPT1 0.0058209 phosphohistidine phosphatase 1 GTEx DepMap Descartes 3.58 920.93
47 NME1 0.0058177 NME/NM23 nucleoside diphosphate kinase 1 GTEx DepMap Descartes 6.77 1245.12
48 DHPS 0.0057815 deoxyhypusine synthase GTEx DepMap Descartes 1.85 481.34
49 HOXD10 0.0057273 homeobox D10 GTEx DepMap Descartes 0.18 42.37
50 LSM7 0.0056764 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated GTEx DepMap Descartes 3.46 1560.25


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UMAP plots showing activity of gene expression program identified in GEP 19. Neuroblastoma #5:

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
FAN_EMBRYONIC_CTX_BIG_GROUPS_INHIBITORY 9.99e-04 51.89 5.39 4.47e-02 6.70e-01
2ERBB4, DCX
 12
HU_FETAL_RETINA_RGC 7.94e-09 10.22 4.95 5.33e-06 5.33e-06
13ISLR2, PAFAH1B3, NEFL, MEIS3, BASP1, DCX, PCSK1N, FEZ1, ELAVL3, ISL1, NEFM, PPP1R14B, NME1
 443
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_IMMATURE_NEURONS 1.66e-05 12.81 4.39 3.71e-03 1.11e-02
6PAFAH1B3, BASP1, DCX, PCSK1N, ELAVL3, CKB
 139
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 2.05e-07 9.33 4.27 6.88e-05 1.38e-04
11KIF21A, SLIT3, PAFAH1B3, KHDRBS3, NEFL, BASP1, DCX, SLITRK4, ELAVL3, ISL1, NEFM
 389
MANNO_MIDBRAIN_NEUROTYPES_HNBML1 3.44e-05 7.44 2.99 5.77e-03 2.31e-02
8ISLR2, KIF21A, PAFAH1B3, BASP1, DCX, PCSK1N, C1QL1, ELAVL3
 328
FAN_OVARY_CL10_PUTATIVE_EARLY_ATRESIA_GRANULOSA_CELL 8.57e-05 7.62 2.87 1.15e-02 5.75e-02
7ACTG1, PRDX2, LDHB, CKB, PHPT1, NME1, LSM7
 274
MURARO_PANCREAS_PANCREATIC_POLYPEPTIDE_CELL 3.45e-04 9.26 2.83 2.57e-02 2.31e-01
5CHRM3, ETV1, PCSK1N, ISL1, GNAS
 155
FAN_OVARY_CL3_MATURE_CUMULUS_GRANULOSA_CELL_1 4.39e-04 6.87 2.37 2.95e-02 2.95e-01
6ACTG1, PRDX2, CKB, BAMBI, PHPT1, LSM7
 254
MANNO_MIDBRAIN_NEUROTYPES_HRN 2.88e-04 6.20 2.34 2.57e-02 1.93e-01
7ISLR2, PAFAH1B3, KHDRBS3, BASP1, DCX, CDC42EP3, ELAVL3
 335
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MATURE_NEURONS 8.02e-04 7.63 2.34 3.85e-02 5.38e-01
5PAFAH1B3, NEFL, PCSK1N, ELAVL3, CKB
 187
BUSSLINGER_GASTRIC_D_CELLS 5.48e-03 20.00 2.24 1.53e-01 1.00e+00
2PCSK1N, ISL1
 28
FAN_OVARY_CL15_SMALL_ANTRAL_FOLLICLE_GRANULOSA_CELL 1.27e-04 4.92 2.19 1.41e-02 8.49e-02
10MAOA, ACTG1, CHRM3, PAFAH1B3, PRMT1, PRDX2, CKB, BAMBI, PHPT1, LSM7
 645
MANNO_MIDBRAIN_NEUROTYPES_HDA1 3.13e-04 4.77 2.03 2.57e-02 2.10e-01
9PRKCA, KIF21A, ERBB4, BASP1, DCX, SLITRK4, KLHL13, PCSK1N, ELAVL3
 584
ZHONG_PFC_C3_MICROGLIA 4.89e-04 4.96 2.00 2.98e-02 3.28e-01
8NFIB, NEFL, DCX, PCSK1N, CDC42EP3, ELAVL3, NEFM, PHPT1
 488
MANNO_MIDBRAIN_NEUROTYPES_HDA 6.16e-04 4.78 1.93 3.25e-02 4.13e-01
8PRKCA, ERBB4, BASP1, DCX, SLITRK4, C1QL1, CDC42EP3, ELAVL3
 506
FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2 6.31e-04 4.31 1.83 3.25e-02 4.23e-01
9PAFAH1B3, PRDX2, MSRB2, LDHB, CKB, BAMBI, PHPT1, NME1, LSM7
 646
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_GLOBOSE_BASAL_CELLS 8.47e-03 15.77 1.78 1.78e-01 1.00e+00
2ELAVL3, CKB
 35
MURARO_PANCREAS_DELTA_CELL 2.83e-03 5.67 1.74 1.05e-01 1.00e+00
5ERBB4, ETV1, PCSK1N, ISL1, BAMBI
 250
MANNO_MIDBRAIN_NEUROTYPES_HOPC 2.76e-03 4.74 1.64 1.05e-01 1.00e+00
6PRKCA, ETV1, SLITRK4, C1QL1, PDGFRA, BAMBI
 366
LAKE_ADULT_KIDNEY_C9_THIN_ASCENDING_LIMB 3.79e-03 5.28 1.62 1.23e-01 1.00e+00
5MAOA, ACTG1, LDHB, GNAS, PPIA
 268

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_PANCREAS_BETA_CELLS 1.10e-02 13.70 1.56 5.48e-01 5.48e-01
2DCX, ISL1
 40
HALLMARK_MYC_TARGETS_V1 4.35e-02 4.05 0.80 8.40e-01 1.00e+00
3PPIA, NME1, LSM7
 200
HALLMARK_UV_RESPONSE_DN 1.10e-01 3.67 0.43 8.40e-01 1.00e+00
2PRKCA, NFIB
 144
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2FOXC1, CKB
 200
HALLMARK_E2F_TARGETS 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2UBE2S, NME1
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2SLIT3, BASP1
 200
HALLMARK_XENOBIOTIC_METABOLISM 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2MAOA, DHPS
 200
HALLMARK_KRAS_SIGNALING_UP 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2ETV1, PCSK1N
 200
HALLMARK_NOTCH_SIGNALING 1.20e-01 8.23 0.20 8.40e-01 1.00e+00
1PRKCA
 32
HALLMARK_APICAL_SURFACE 1.61e-01 5.93 0.14 8.40e-01 1.00e+00
1GATA3
 44
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 1.77e-01 5.31 0.13 8.40e-01 1.00e+00
1PRDX2
 49
HALLMARK_CHOLESTEROL_HOMEOSTASIS 2.55e-01 3.49 0.09 8.82e-01 1.00e+00
1ACTG1
 74
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 8.82e-01 1.00e+00
1GNAS
 96
HALLMARK_SPERMATOGENESIS 4.15e-01 1.90 0.05 8.82e-01 1.00e+00
1PCSK1N
 135
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 8.82e-01 1.00e+00
1MSRB2
 138
HALLMARK_DNA_REPAIR 4.49e-01 1.71 0.04 8.82e-01 1.00e+00
1NME1
 150
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 8.82e-01 1.00e+00
1MAOA
 158
HALLMARK_UV_RESPONSE_UP 4.66e-01 1.62 0.04 8.82e-01 1.00e+00
1MAOA
 158
HALLMARK_APOPTOSIS 4.72e-01 1.59 0.04 8.82e-01 1.00e+00
1FEZ1
 161
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 8.82e-01 1.00e+00
1PRKCA
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_VIBRIO_CHOLERAE_INFECTION 1.26e-03 15.63 3.02 1.18e-01 2.35e-01
3PRKCA, ACTG1, GNAS
 54
KEGG_CALCIUM_SIGNALING_PATHWAY 6.44e-04 8.03 2.46 1.18e-01 1.20e-01
5PRKCA, CHRM3, ERBB4, PDGFRA, GNAS
 178
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 8.00e-03 16.26 1.84 3.72e-01 1.00e+00
2GMDS, PHPT1
 34
KEGG_GAP_JUNCTION 5.37e-03 9.17 1.79 3.33e-01 1.00e+00
3PRKCA, PDGFRA, GNAS
 90
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 1.87e-02 10.20 1.17 5.51e-01 1.00e+00
2NEFL, NEFM
 53
KEGG_ARGININE_AND_PROLINE_METABOLISM 1.94e-02 10.01 1.15 5.51e-01 1.00e+00
2MAOA, CKB
 54
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.07e-02 9.64 1.11 5.51e-01 1.00e+00
2PRKCA, ACTG1
 56
KEGG_GLIOMA 2.73e-02 8.26 0.95 6.33e-01 1.00e+00
2PRKCA, PDGFRA
 65
KEGG_ENDOCYTOSIS 3.40e-02 4.48 0.88 6.33e-01 1.00e+00
3PSD3, ERBB4, PDGFRA
 181
KEGG_LONG_TERM_DEPRESSION 3.13e-02 7.66 0.88 6.33e-01 1.00e+00
2PRKCA, GNAS
 70
KEGG_FOCAL_ADHESION 4.30e-02 4.07 0.80 6.73e-01 1.00e+00
3PRKCA, ACTG1, PDGFRA
 199
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.07e-02 3.80 0.75 6.73e-01 1.00e+00
3ACTG1, CHRM3, PDGFRA
 213
KEGG_ERBB_SIGNALING_PATHWAY 4.64e-02 6.13 0.71 6.73e-01 1.00e+00
2PRKCA, ERBB4
 87
KEGG_DILATED_CARDIOMYOPATHY 4.93e-02 5.92 0.69 6.73e-01 1.00e+00
2ACTG1, GNAS
 90
KEGG_GNRH_SIGNALING_PATHWAY 6.04e-02 5.26 0.61 6.77e-01 1.00e+00
2PRKCA, GNAS
 101
KEGG_MELANOGENESIS 6.04e-02 5.26 0.61 6.77e-01 1.00e+00
2PRKCA, GNAS
 101
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 7.56e-02 4.61 0.54 7.13e-01 1.00e+00
2PRKCA, GNAS
 115
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 7.67e-02 4.57 0.53 7.13e-01 1.00e+00
2PRKCA, ACTG1
 116
KEGG_TIGHT_JUNCTION 9.54e-02 4.01 0.47 8.37e-01 1.00e+00
2PRKCA, ACTG1
 132
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 9.90e-02 3.92 0.46 8.37e-01 1.00e+00
2UBE2S, KLHL13
 135

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr6p25 4.17e-02 6.51 0.75 1.00e+00 1.00e+00
2FOXC1, GMDS
 82
chr8p21 9.06e-02 4.13 0.48 1.00e+00 1.00e+00
2NEFL, NEFM
 128
chr10p12 9.90e-02 3.92 0.46 1.00e+00 1.00e+00
2MSRB2, BAMBI
 135
chr19p13 5.35e-01 1.41 0.37 1.00e+00 1.00e+00
4PRDX2, ELAVL3, DHPS, LSM7
 773
chr19q13 1.00e+00 0.94 0.24 1.00e+00 1.00e+00
4PAFAH1B3, PRMT1, MEIS3, UBE2S
 1165
chrXp11 6.55e-01 1.42 0.17 1.00e+00 1.00e+00
2MAOA, PCSK1N
 370
chr2q34 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1ERBB4
 45
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1PSD3
 45
chr10p14 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1GATA3
 47
chr17q21 6.95e-01 1.14 0.13 1.00e+00 1.00e+00
2C1QL1, NME1
 457
chr7p13 1.81e-01 5.21 0.13 1.00e+00 1.00e+00
1PPIA
 50
chr12q12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1KIF21A
 58
chr1q43 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1CHRM3
 60
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1PDGFRA
 79
chrXq24 2.73e-01 3.23 0.08 1.00e+00 1.00e+00
1KLHL13
 80
chr2q36 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1NYAP2
 82
chr7p21 2.81e-01 3.11 0.08 1.00e+00 1.00e+00
1ETV1
 83
chr5q11 2.87e-01 3.04 0.07 1.00e+00 1.00e+00
1ISL1
 85
chrXq23 2.98e-01 2.90 0.07 1.00e+00 1.00e+00
1DCX
 89
chrXq27 2.98e-01 2.90 0.07 1.00e+00 1.00e+00
1SLITRK4
 89

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
EN1_01 9.45e-04 10.15 2.61 2.68e-01 1.00e+00
4ERBB4, ISL1, PDGFRA, HOXD10
 111
ZMYM2_TARGET_GENES 1.64e-03 8.69 2.24 2.68e-01 1.00e+00
4PRDX2, BASP1, PPP1R14B, PPIA
 129
HFH8_01 1.28e-03 6.84 2.10 2.68e-01 1.00e+00
5KIF21A, SLIT3, NFIB, ETV1, BAMBI
 208
ZNF512B_TARGET_GENES 1.57e-03 6.52 2.00 2.68e-01 1.00e+00
5PRKCA, ISLR2, GATA3, GNAS, DHPS
 218
CHX10_01 1.91e-03 6.23 1.91 2.68e-01 1.00e+00
5MAOA, NFIB, BASP1, ETV1, BAMBI
 228
SYATTGTG_UNKNOWN 2.06e-03 6.12 1.88 2.68e-01 1.00e+00
5KIF21A, NFIB, SLITRK4, PCSK1N, FEZ1
 232
SOX9_B1 2.29e-03 5.96 1.83 2.68e-01 1.00e+00
5NFIB, BASP1, DCX, ETV1, KLHL13
 238
GATA1_02 2.78e-03 5.69 1.75 2.68e-01 1.00e+00
5NFIB, PRDX2, CDC42EP3, ISL1, PDGFRA
 249
CP2_02 2.97e-03 5.60 1.72 2.68e-01 1.00e+00
5TBX2, DCX, ETV1, CDC42EP3, PHPT1
 253
PAX4_03 3.12e-03 5.53 1.70 2.68e-01 1.00e+00
5NFIB, PRMT1, PCSK1N, C1QL1, NDN
 256
SRY_02 3.28e-03 5.47 1.68 2.68e-01 1.00e+00
5NFIB, KLHL13, CDC42EP3, BAMBI, HOXD10
 259
PBX1_01 3.33e-03 5.45 1.67 2.68e-01 1.00e+00
5NFIB, ERBB4, DCX, FEZ1, HOXD10
 260
NCX_01 4.96e-03 6.32 1.63 3.12e-01 1.00e+00
4DCX, ETV1, ISL1, GNAS
 176
OCT1_06 3.79e-03 5.28 1.62 2.68e-01 1.00e+00
5NFIB, ERBB4, SLITRK4, KLHL13, CDC42EP3
 268
GATA2_01 8.20e-03 7.82 1.53 3.80e-01 1.00e+00
3GATA3, PDGFRA, GNAS
 105
YYCATTCAWW_UNKNOWN 6.70e-03 5.78 1.50 3.62e-01 1.00e+00
4UBE2S, ERBB4, BASP1, CKB
 192
GATAAGR_GATA_C 5.94e-03 4.72 1.45 3.37e-01 1.00e+00
5NFIB, ETV1, CDC42EP3, ISL1, HOXD10
 299
TAATTA_CHX10_01 3.11e-03 3.37 1.44 2.68e-01 1.00e+00
9PSD3, ERBB4, BASP1, DCX, ETV1, CDC42EP3, PDGFRA, GNAS, BAMBI
 823
FREAC7_01 7.71e-03 5.55 1.44 3.80e-01 1.00e+00
4NFIB, CDC42EP3, FEZ1, BAMBI
 200
GATA_Q6 7.84e-03 5.52 1.43 3.80e-01 1.00e+00
4DCX, CDC42EP3, ISL1, PDGFRA
 201

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION 1.27e-05 88.17 14.90 1.39e-02 9.52e-02
3ETV1, ISL1, HOXD10
 12
GOBP_INTERMEDIATE_FILAMENT_BUNDLE_ASSEMBLY 3.22e-04 103.49 9.64 1.10e-01 1.00e+00
2NEFL, NEFM
 7
GOBP_PLATELET_AGGREGATION 4.36e-06 24.32 7.27 8.85e-03 3.26e-02
5PRKCA, ACTG1, PDGFRA, GNAS, PPIA
 62
GOBP_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION 6.85e-04 64.86 6.55 1.31e-01 1.00e+00
2ISL1, HOXD10
 10
GOBP_CARDIAC_MUSCLE_CELL_MYOBLAST_DIFFERENTIATION 8.35e-04 57.69 5.91 1.49e-01 1.00e+00
2TBX2, ISL1
 11
GOBP_POSITIVE_REGULATION_OF_DNA_BINDING 6.91e-05 20.88 5.27 3.45e-02 5.17e-01
4FOXC1, ISL1, GATA3, NME1
 56
GOBP_HOMOTYPIC_CELL_CELL_ADHESION 2.04e-05 17.34 5.24 1.39e-02 1.53e-01
5PRKCA, ACTG1, PDGFRA, GNAS, PPIA
 85
GOBP_POSTSYNAPTIC_CYTOSKELETON_ORGANIZATION 1.18e-03 47.19 4.96 1.67e-01 1.00e+00
2ACTG1, NEFL
 13
GOBP_AXONAL_TRANSPORT_OF_MITOCHONDRION 1.37e-03 43.30 4.59 1.83e-01 1.00e+00
2NEFL, FEZ1
 14
GOBP_CELL_FATE_DETERMINATION 5.65e-04 20.97 4.00 1.31e-01 1.00e+00
3TBX2, ISL1, GATA3
 41
GOBP_CARDIAC_CHAMBER_MORPHOGENESIS 8.65e-05 12.62 3.84 4.05e-02 6.47e-01
5FOXC1, TBX2, SLIT3, ISL1, GATA3
 115
GOBP_POSITIVE_REGULATION_OF_HEART_GROWTH 6.96e-04 19.44 3.72 1.31e-01 1.00e+00
3TBX2, ERBB4, BASP1
 44
GOBP_CARDIOBLAST_DIFFERENTIATION 2.54e-03 30.58 3.34 2.62e-01 1.00e+00
2TBX2, ISL1
 19
GOBP_MESENCHYMAL_TO_EPITHELIAL_TRANSITION 2.54e-03 30.58 3.34 2.62e-01 1.00e+00
2BASP1, GATA3
 19
GOBP_MESENCHYME_MORPHOGENESIS 9.53e-04 17.32 3.33 1.62e-01 1.00e+00
3FOXC1, TBX2, ISL1
 49
GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 1.07e-03 16.60 3.20 1.63e-01 1.00e+00
3FOXC1, ISL1, BAMBI
 51
GOBP_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS 2.81e-03 28.89 3.17 2.77e-01 1.00e+00
2ISL1, GATA3
 20
GOBP_NEURON_DEVELOPMENT 1.92e-07 5.90 3.07 1.44e-03 1.44e-03
17NYAP2, PRKCA, ISLR2, SLIT3, NFIB, NEFL, PRMT1, DCX, ETV1, SLITRK4, C1QL1, FEZ1, ISL1, GATA3, NDN, NME1, HOXD10
 1109
GOBP_CARDIAC_SEPTUM_DEVELOPMENT 5.50e-04 11.81 3.03 1.31e-01 1.00e+00
4TBX2, SLIT3, ISL1, GATA3
 96
GOBP_POSITIVE_REGULATION_OF_ORGAN_GROWTH 1.26e-03 15.63 3.02 1.74e-01 1.00e+00
3TBX2, ERBB4, BASP1
 54

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_4H_DN 1.24e-04 8.78 3.02 6.03e-01 6.03e-01
6MAOA, PAFAH1B3, PRDX2, ETV1, LDHB, PPP1R14B
 200
GSE22886_NAIVE_TCELL_VS_NKCELL_UP 1.03e-03 7.19 2.20 1.00e+00 1.00e+00
5PRKCA, TBX2, PAFAH1B3, LDHB, DHPS
 198
GSE22886_NAIVE_CD8_TCELL_VS_NKCELL_UP 1.03e-03 7.19 2.20 1.00e+00 1.00e+00
5PRKCA, TBX2, PAFAH1B3, LDHB, DHPS
 198
GSE23398_WT_VS_IL2_KO_CD4_TCELL_SCURFY_MOUSE_UP 1.06e-03 7.16 2.19 1.00e+00 1.00e+00
5BASP1, DCX, CKB, GNAS, PPIA
 199
GSE10240_CTRL_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5MAOA, PSD3, SLIT3, KHDRBS3, BASP1
 200
GSE22611_UNSTIM_VS_6H_MDP_STIM_NOD2_TRANSDUCED_HEK293T_CELL_UP 7.20e-03 5.66 1.47 1.00e+00 1.00e+00
4NFIB, FEZ1, PPP1R14B, PPIA
 196
GSE10325_CD4_TCELL_VS_BCELL_UP 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4PRKCA, PRDX2, LDHB, GATA3
 198
GSE8685_IL2_STARVED_VS_IL15_ACT_IL2_STARVED_CD4_TCELL_UP 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4PRKCA, GATA3, CKB, PHPT1
 198
GSE29949_CD8_NEG_DC_SPLEEN_VS_MONOCYTE_BONE_MARROW_UP 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4MAOA, BASP1, GATA3, PPIA
 198
GSE12845_IGD_POS_BLOOD_VS_DARKZONE_GC_TONSIL_BCELL_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4PRKCA, UBE2S, PPP1R14B, PPIA
 199
GSE22886_TCELL_VS_BCELL_NAIVE_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4PRKCA, ACTG1, LDHB, GATA3
 199
GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4MSRB2, ETV1, ISL1, CKB
 199
GSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4ACTG1, BASP1, C1QL1, NEFM
 199
GSE40443_INDUCED_VS_TOTAL_TREG_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4PAFAH1B3, BASP1, LDHB, GATA3
 199
GSE1448_ANTI_VALPHA2_VS_VBETA5_DP_THYMOCYTE_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4PRKCA, ACTG1, BASP1, DHPS
 200
GSE17721_CTRL_VS_PAM3CSK4_6H_BMDC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4TBX2, DCX, ETV1, DHPS
 200
GSE22886_DAY1_VS_DAY7_MONOCYTE_IN_CULTURE_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4LDHB, GNAS, PPIA, NME1
 200
GSE29618_MONOCYTE_VS_MDC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4ACTG1, BASP1, PPP1R14B, NME1
 200
GSE32423_MEMORY_VS_NAIVE_CD8_TCELL_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4FOXC1, PSD3, BASP1, LDHB
 200
GSE3039_CD4_TCELL_VS_B1_BCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4PRDX2, UBE2S, CKB, NME1
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
FOXC1 2 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TBX2 6 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NFIB 13 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MEIS3 20 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
H1FX 24 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone component
MSRB2 25 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The paper cited by GO (PMID:10375640) called MSRB2 a TF based on amino acid sequence analysis, but did not provide any direct evidence
ETV1 27 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ISL1 35 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
GATA3 39 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NDN 43 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HOXD10 49 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
SOX11 54 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
PSMC5 58 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
BPTF 65 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook (PMID: 10575013) obtained a motif by SELEX and showed that mutating the sequence diminished binding in vitro. Unusual for a PHD/Ring finger, but its there in the literature.
IRX5 68 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HMGB3 70 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Similar to HMGB½, which bind DNA with low specificity
CBFA2T3 72 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Co-repressor - does not contact DNA (PMID: 12559562; PMID: 15203199)
NKX6-2 79 Yes Known motif Monomer or homomultimer High-throughput in vitro Has a putative AT-hook None
IRX3 87 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HOXD9 96 Yes Known motif Monomer or homomultimer High-throughput in vitro None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T162_ACATGCACACACCGAC-1 Neurons:adrenal_medulla_cell_line 0.21 646.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_2lox-17: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33
T162_AACAAAGTCGTGCGAC-1 Neurons:adrenal_medulla_cell_line 0.19 573.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_2lox-22: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-5: 0.31
T162_ATTCGTTGTTAGTTCG-1 Neurons:adrenal_medulla_cell_line 0.20 561.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32
T162_CTGCCATAGGGCAATC-1 Neurons:adrenal_medulla_cell_line 0.22 532.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-22: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32
T162_GCAGGCTTCCTAAACG-1 Neurons:adrenal_medulla_cell_line 0.20 470.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-17: 0.31
T162_GCCATTCCAGAGGGTT-1 Neurons:adrenal_medulla_cell_line 0.19 460.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.32
T162_ACCTACCTCGTTCCCA-1 Neurons:adrenal_medulla_cell_line 0.20 432.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_2lox-17: 0.29, iPS_cells:PDB_2lox-5: 0.29
T162_GGGTAGAGTCTGGTTA-1 Neurons:adrenal_medulla_cell_line 0.18 429.88
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32
T162_CATCCCACACCAGTTA-1 Neurons:adrenal_medulla_cell_line 0.20 428.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_2lox-17: 0.29, iPS_cells:PDB_2lox-21: 0.29
T162_GAACGTTTCATCCTGC-1 Neurons:adrenal_medulla_cell_line 0.19 425.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-17: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_2lox-5: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3
T162_AGTACCAGTACAAACA-1 Neurons:adrenal_medulla_cell_line 0.21 423.90
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32, Embryonic_stem_cells: 0.31
T162_AGCGCTGAGGTGCTAG-1 Neurons:adrenal_medulla_cell_line 0.18 390.09
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_2lox-21: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_2lox-17: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_2lox-5: 0.3
T162_TGTCCCAAGGGCTTCC-1 Neurons:adrenal_medulla_cell_line 0.20 386.62
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-21: 0.3, iPS_cells:PDB_2lox-17: 0.3
T162_GCATGATGTCTTACTT-1 Neurons:adrenal_medulla_cell_line 0.20 381.00
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-17: 0.27
T162_GATGGAGAGTAGACCG-1 Neurons:adrenal_medulla_cell_line 0.18 368.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_2lox-17: 0.29, iPS_cells:PDB_2lox-21: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29
T162_ATCCATTCACTCCTTG-1 Neurons:adrenal_medulla_cell_line 0.20 368.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.37, iPS_cells:PDB_2lox-22: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.35, iPS_cells:PDB_1lox-17Puro-10: 0.35, iPS_cells:PDB_1lox-21Puro-26: 0.35, iPS_cells:PDB_1lox-17Puro-5: 0.35, iPS_cells:PDB_2lox-17: 0.35, iPS_cells:PDB_2lox-21: 0.35, Embryonic_stem_cells: 0.35
T162_ATTCCCGGTCATTGCA-1 Neurons:adrenal_medulla_cell_line 0.20 366.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-21: 0.32
T162_TCAGCAAAGTGAGTGC-1 Neurons:adrenal_medulla_cell_line 0.19 364.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_2lox-21: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29
T162_ACGTACAAGTGCCCGT-1 Neurons:adrenal_medulla_cell_line 0.18 363.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.33, iPS_cells:PDB_2lox-22: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_2lox-21: 0.3, iPS_cells:PDB_2lox-17: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3
T162_GTTCGCTCAGCTATTG-1 Neurons:adrenal_medulla_cell_line 0.19 353.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_2lox-21: 0.26
T162_CTCAACCAGATGACCG-1 Neurons:adrenal_medulla_cell_line 0.20 351.80
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_2lox-5: 0.3
T162_CAGCACGAGTTCTCTT-1 Neurons:adrenal_medulla_cell_line 0.16 349.77
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, Tissue_stem_cells:CD326-CD56+: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, Embryonic_stem_cells: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_2lox-5: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26
T162_TACACCCCAGAGTTCT-1 Neurons:adrenal_medulla_cell_line 0.20 349.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.31
T162_TTTGGAGAGTTCTCTT-1 Neurons:adrenal_medulla_cell_line 0.18 347.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_2lox-22: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_2lox-21: 0.3
T162_CCGTGAGAGCGCCCAT-1 Neurons:adrenal_medulla_cell_line 0.16 341.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.26
T162_CGAATTGGTGGAACCA-1 Neurons:adrenal_medulla_cell_line 0.21 340.58
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-17: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33
T162_ACGGTTAAGCACTAGG-1 Neurons:adrenal_medulla_cell_line 0.20 339.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_2lox-21: 0.3, iPS_cells:PDB_2lox-17: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3
T162_GAGACCCGTACTAACC-1 Neurons:adrenal_medulla_cell_line 0.18 337.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_2lox-21: 0.29, iPS_cells:PDB_2lox-17: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_2lox-5: 0.28
T162_CATGGTACACAATTCG-1 Neurons:adrenal_medulla_cell_line 0.18 335.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32
T162_TCCATCGTCCCAACTC-1 Neurons:adrenal_medulla_cell_line 0.19 330.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_2lox-17: 0.29, iPS_cells:PDB_2lox-21: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_2lox-5: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28
T162_ATTCACTAGACAGCGT-1 Neurons:adrenal_medulla_cell_line 0.18 322.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.27, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_2lox-21: 0.26, iPS_cells:PDB_2lox-5: 0.26, iPS_cells:PDB_2lox-17: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.26
T162_CCTGTTGCAAATGGCG-1 Neurons:adrenal_medulla_cell_line 0.19 315.41
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_2lox-17: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Embryonic_stem_cells: 0.33
T162_GTAGTACAGGAATCGC-1 Neurons:adrenal_medulla_cell_line 0.19 310.93
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_2lox-17: 0.33, Embryonic_stem_cells: 0.33
T162_ACGATGTTCCCTAGGG-1 Neurons:adrenal_medulla_cell_line 0.18 309.64
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.27, Embryonic_stem_cells: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_2lox-22: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_2lox-5: 0.25
T162_CTGTACCAGCCATTCA-1 Neurons:adrenal_medulla_cell_line 0.19 309.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_2lox-5: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-17: 0.31
T162_AAACCCAGTACGTACT-1 Neurons:adrenal_medulla_cell_line 0.08 306.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.28, Neurons:Schwann_cell: 0.28, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.27, Smooth_muscle_cells:umbilical_vein: 0.27, iPS_cells:PDB_2lox-22: 0.27, Macrophage:monocyte-derived: 0.27, iPS_cells:PDB_2lox-21: 0.27, Pro-B_cell_CD34+: 0.27
T162_TTCACGCAGTCAGGGT-1 Neurons:adrenal_medulla_cell_line 0.21 306.11
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-17: 0.32, iPS_cells:PDB_2lox-21: 0.32
T162_TCTAACTTCGCACGGT-1 Neurons:adrenal_medulla_cell_line 0.21 297.42
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.29, iPS_cells:PDB_2lox-22: 0.29, iPS_cells:PDB_2lox-21: 0.29
T162_CAGCACGAGTGTTGTC-1 Neurons:adrenal_medulla_cell_line 0.17 296.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_2lox-21: 0.28, iPS_cells:PDB_2lox-17: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28
T162_CATTGCCAGACCTCCG-1 Neurons:adrenal_medulla_cell_line 0.20 295.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-17: 0.33, iPS_cells:PDB_2lox-21: 0.33, iPS_cells:PDB_2lox-5: 0.33
T162_TTCTAACCACATACTG-1 Neurons:adrenal_medulla_cell_line 0.20 294.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-17: 0.31
T162_GTTACGAGTCTACATG-1 Neurons:adrenal_medulla_cell_line 0.18 293.41
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_2lox-21: 0.3, iPS_cells:PDB_2lox-17: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3
T162_TGATGGTAGGTCGTAG-1 Neurons:adrenal_medulla_cell_line 0.19 286.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.27, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_1lox-21Puro-26: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.27, iPS_cells:PDB_2lox-21: 0.27, iPS_cells:PDB_2lox-17: 0.27, iPS_cells:PDB_1lox-17Puro-5: 0.27
T162_CTTCGGTTCCATGCAA-1 Neurons:adrenal_medulla_cell_line 0.20 284.91
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Embryonic_stem_cells: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-22: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.31
T162_CACCAAACATTCACAG-1 Neurons:adrenal_medulla_cell_line 0.20 284.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, Embryonic_stem_cells: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_2lox-22: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, Tissue_stem_cells:CD326-CD56+: 0.3
T162_TCTACCGAGTCACGAG-1 Neurons:adrenal_medulla_cell_line 0.21 282.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.32, iPS_cells:PDB_2lox-21: 0.31, iPS_cells:PDB_2lox-17: 0.31
T162_ATTTCACAGAGTAACT-1 Neurons:adrenal_medulla_cell_line 0.24 273.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_2lox-22: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.32, iPS_cells:PDB_2lox-21: 0.32, iPS_cells:PDB_2lox-17: 0.32
T162_GCAGCTGCATCGGTTA-1 Neurons:adrenal_medulla_cell_line 0.20 273.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.41, Neuroepithelial_cell:ESC-derived: 0.35, iPS_cells:PDB_1lox-21Puro-20: 0.34, iPS_cells:PDB_2lox-22: 0.34, iPS_cells:PDB_1lox-21Puro-26: 0.34, iPS_cells:PDB_2lox-21: 0.34, iPS_cells:PDB_1lox-17Puro-10: 0.34, iPS_cells:PDB_2lox-17: 0.34, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-5: 0.33
T162_CATTCATTCAGGACGA-1 Neurons:adrenal_medulla_cell_line 0.18 272.22
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, iPS_cells:PDB_2lox-22: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_2lox-21: 0.28, iPS_cells:PDB_2lox-17: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28
T162_CCTGTTGGTGGTATGG-1 Neurons:adrenal_medulla_cell_line 0.20 269.18
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_2lox-22: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_2lox-21: 0.3


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.33e-05
Mean rank of genes in gene set: 1920.55
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NEFL 0.0075750 17 GTEx DepMap Descartes 1.93 179.74
BASP1 0.0070053 23 GTEx DepMap Descartes 9.00 1720.93
ELAVL3 0.0064217 34 GTEx DepMap Descartes 2.55 176.67
ISL1 0.0063018 35 GTEx DepMap Descartes 2.67 403.87
NEFM 0.0062099 37 GTEx DepMap Descartes 1.94 194.84
RTN1 0.0045443 83 GTEx DepMap Descartes 5.91 622.83
CCND1 0.0032464 192 GTEx DepMap Descartes 6.25 534.71
INA 0.0013120 1084 GTEx DepMap Descartes 0.79 83.68
STMN2 0.0011711 1289 GTEx DepMap Descartes 14.31 2558.61
STMN1 -0.0000326 5882 GTEx DepMap Descartes 10.23 1101.52
ELAVL4 -0.0023981 12450 GTEx DepMap Descartes 1.97 143.42


Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.29e-04
Mean rank of genes in gene set: 344.25
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MIF 0.0046794 76 GTEx DepMap Descartes 4.03 1402.14
NPM1 0.0030948 213 GTEx DepMap Descartes 11.10 1926.91
TPI1 0.0028948 252 GTEx DepMap Descartes 4.40 797.15
TK1 0.0015607 836 GTEx DepMap Descartes 0.40 78.83


Bridge (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Bridge subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.68e-03
Mean rank of genes in gene set: 3208.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
LDHB 0.0062519 36 GTEx DepMap Descartes 7.99 1650.34
CKB 0.0061598 41 GTEx DepMap Descartes 6.12 1414.90
SOX11 0.0054880 54 GTEx DepMap Descartes 3.41 129.78
DLL3 0.0027205 289 GTEx DepMap Descartes 0.49 67.97
NFASC 0.0013714 1021 GTEx DepMap Descartes 0.17 5.15
GSE1 0.0012681 1149 GTEx DepMap Descartes 0.35 NA
WDR6 0.0011908 1266 GTEx DepMap Descartes 0.40 31.26
MIAT 0.0008640 1815 GTEx DepMap Descartes 0.51 17.77
RCC2 0.0001214 4846 GTEx DepMap Descartes 0.26 20.58
DPYSL3 0.0000693 5178 GTEx DepMap Descartes 0.80 46.36
TBX20 -0.0006749 10429 GTEx DepMap Descartes 0.00 0.00
CDKN1C -0.0021019 12380 GTEx DepMap Descartes 0.24 39.46




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.43e-18
Mean rank of genes in gene set: 4530.54
Median rank of genes in gene set: 2584
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
KIF21A 0.0081864 10 GTEx DepMap Descartes 3.78 198.79
SLIT3 0.0079606 11 GTEx DepMap Descartes 1.18 46.66
MARCH11 0.0079568 12 GTEx DepMap Descartes 3.10 NA
NEFL 0.0075750 17 GTEx DepMap Descartes 1.93 179.74
H1FX 0.0069797 24 GTEx DepMap Descartes 5.81 NA
DCX 0.0069085 26 GTEx DepMap Descartes 1.95 71.98
KLHL13 0.0065797 29 GTEx DepMap Descartes 0.75 52.35
CDC42EP3 0.0064864 32 GTEx DepMap Descartes 1.11 75.47
ELAVL3 0.0064217 34 GTEx DepMap Descartes 2.55 176.67
ISL1 0.0063018 35 GTEx DepMap Descartes 2.67 403.87
NEFM 0.0062099 37 GTEx DepMap Descartes 1.94 194.84
GATA3 0.0061806 39 GTEx DepMap Descartes 3.80 436.39
CKB 0.0061598 41 GTEx DepMap Descartes 6.12 1414.90
PHPT1 0.0058209 46 GTEx DepMap Descartes 3.58 920.93
SOX11 0.0054880 54 GTEx DepMap Descartes 3.41 129.78
ANK2 0.0053803 55 GTEx DepMap Descartes 1.12 25.69
GLRX 0.0053718 56 GTEx DepMap Descartes 1.01 110.76
MAP1B 0.0053309 57 GTEx DepMap Descartes 7.84 228.86
SV2C 0.0051956 62 GTEx DepMap Descartes 0.42 13.95
AKAP12 0.0051621 63 GTEx DepMap Descartes 1.63 68.36
GLCCI1 0.0050993 66 GTEx DepMap Descartes 1.41 102.00
RTN1 0.0045443 83 GTEx DepMap Descartes 5.91 622.83
NCAM1 0.0044798 89 GTEx DepMap Descartes 2.32 136.68
RNF150 0.0044743 90 GTEx DepMap Descartes 0.49 15.63
CXADR 0.0042729 94 GTEx DepMap Descartes 0.80 52.17
ENDOG 0.0041214 104 GTEx DepMap Descartes 1.26 373.24
SHD 0.0041014 108 GTEx DepMap Descartes 0.97 188.70
CENPV 0.0039867 116 GTEx DepMap Descartes 3.23 579.48
CHML 0.0039349 122 GTEx DepMap Descartes 0.60 25.73
GAL 0.0038320 126 GTEx DepMap Descartes 2.08 896.73


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8761.99
Median rank of genes in gene set: 9768
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PRDX4 0.0040293 114 GTEx DepMap Descartes 1.49 478.95
CDH11 0.0039407 121 GTEx DepMap Descartes 0.18 10.26
TPBG 0.0027376 283 GTEx DepMap Descartes 0.11 6.02
MMP2 0.0024033 386 GTEx DepMap Descartes 0.28 29.55
FZD2 0.0023508 410 GTEx DepMap Descartes 0.11 10.00
PRDX6 0.0019302 589 GTEx DepMap Descartes 1.51 280.25
LAPTM4A 0.0017820 680 GTEx DepMap Descartes 1.35 327.29
DDR2 0.0017424 706 GTEx DepMap Descartes 0.20 6.12
F2R 0.0016195 787 GTEx DepMap Descartes 0.20 16.85
PTGFRN 0.0015979 805 GTEx DepMap Descartes 0.10 5.93
FKBP14 0.0015969 807 GTEx DepMap Descartes 0.08 5.30
DMD 0.0015911 812 GTEx DepMap Descartes 0.12 3.21
PHLDA3 0.0015800 822 GTEx DepMap Descartes 0.17 23.81
ACAP2 0.0015456 851 GTEx DepMap Descartes 0.33 16.20
MYL12B 0.0015066 885 GTEx DepMap Descartes 2.06 550.49
ENAH 0.0014689 921 GTEx DepMap Descartes 1.05 23.21
ANTXR1 0.0014647 923 GTEx DepMap Descartes 0.11 5.99
RCN1 0.0014170 968 GTEx DepMap Descartes 0.41 45.92
PPIB 0.0014108 975 GTEx DepMap Descartes 2.68 717.90
ELAVL1 0.0010308 1496 GTEx DepMap Descartes 0.44 22.14
ATP2B1 0.0010231 1509 GTEx DepMap Descartes 0.57 27.58
AMMECR1 0.0010020 1542 GTEx DepMap Descartes 0.09 5.83
PALLD 0.0009891 1563 GTEx DepMap Descartes 0.21 11.73
JAM3 0.0009584 1622 GTEx DepMap Descartes 0.14 11.89
MANF 0.0009448 1643 GTEx DepMap Descartes 0.66 145.96
NFIC 0.0009366 1659 GTEx DepMap Descartes 0.24 9.06
EMILIN1 0.0009083 1721 GTEx DepMap Descartes 0.15 13.17
CBLB 0.0008479 1851 GTEx DepMap Descartes 0.15 7.72
ARMCX2 0.0008458 1855 GTEx DepMap Descartes 0.16 17.49
SEMA3C 0.0007929 1990 GTEx DepMap Descartes 0.05 3.33


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.94e-01
Mean rank of genes in gene set: 6580.03
Median rank of genes in gene set: 6965
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FDPS 0.0024811 360 GTEx DepMap Descartes 1.03 173.80
FDXR 0.0022597 449 GTEx DepMap Descartes 0.20 29.06
TM7SF2 0.0014375 945 GTEx DepMap Descartes 0.30 49.85
GSTA4 0.0012710 1142 GTEx DepMap Descartes 0.76 141.51
JAKMIP2 0.0011042 1397 GTEx DepMap Descartes 0.28 10.55
SCAP 0.0008345 1885 GTEx DepMap Descartes 0.19 14.91
SH3BP5 0.0007461 2123 GTEx DepMap Descartes 0.34 31.82
SLC16A9 0.0004621 3085 GTEx DepMap Descartes 0.07 5.46
PDE10A 0.0003609 3525 GTEx DepMap Descartes 0.06 2.88
SLC1A2 0.0003275 3681 GTEx DepMap Descartes 0.18 4.63
DHCR7 0.0003179 3740 GTEx DepMap Descartes 0.10 13.67
POR 0.0003052 3808 GTEx DepMap Descartes 0.17 23.37
HMGCR 0.0002921 3866 GTEx DepMap Descartes 0.22 15.21
MSMO1 0.0002890 3889 GTEx DepMap Descartes 0.24 35.12
GRAMD1B 0.0000427 5373 GTEx DepMap Descartes 0.04 1.67
STAR -0.0001061 6591 GTEx DepMap Descartes 0.01 0.77
FDX1 -0.0001136 6661 GTEx DepMap Descartes 0.32 31.46
FREM2 -0.0001474 6957 GTEx DepMap Descartes 0.00 0.00
SCARB1 -0.0001493 6973 GTEx DepMap Descartes 0.06 3.42
HMGCS1 -0.0002374 7765 GTEx DepMap Descartes 0.19 11.39
SH3PXD2B -0.0002564 7932 GTEx DepMap Descartes 0.03 1.19
CYB5B -0.0002764 8110 GTEx DepMap Descartes 0.24 18.36
SGCZ -0.0002779 8126 GTEx DepMap Descartes 0.01 0.29
INHA -0.0003327 8546 GTEx DepMap Descartes 0.00 0.77
FRMD5 -0.0003897 8934 GTEx DepMap Descartes 0.03 1.23
NPC1 -0.0005076 9643 GTEx DepMap Descartes 0.03 1.42
LDLR -0.0005409 9819 GTEx DepMap Descartes 0.03 1.63
BAIAP2L1 -0.0005571 9897 GTEx DepMap Descartes 0.01 0.29
PAPSS2 -0.0006778 10440 GTEx DepMap Descartes 0.01 0.75
ERN1 -0.0007361 10655 GTEx DepMap Descartes 0.04 1.83


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.94e-01
Mean rank of genes in gene set: 6737.49
Median rank of genes in gene set: 9122
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCH11 0.0079568 12 GTEx DepMap Descartes 3.10 NA
BASP1 0.0070053 23 GTEx DepMap Descartes 9.00 1720.93
ISL1 0.0063018 35 GTEx DepMap Descartes 2.67 403.87
MAP1B 0.0053309 57 GTEx DepMap Descartes 7.84 228.86
GAL 0.0038320 126 GTEx DepMap Descartes 2.08 896.73
ALK 0.0036112 145 GTEx DepMap Descartes 0.20 12.51
NPY 0.0035319 159 GTEx DepMap Descartes 11.57 5928.12
CCND1 0.0032464 192 GTEx DepMap Descartes 6.25 534.71
TUBA1A 0.0025267 345 GTEx DepMap Descartes 22.30 3998.43
MAB21L1 0.0023653 404 GTEx DepMap Descartes 1.03 123.12
RPH3A 0.0023253 420 GTEx DepMap Descartes 0.10 7.42
FAT3 0.0015095 882 GTEx DepMap Descartes 0.16 2.59
SLC6A2 0.0014312 951 GTEx DepMap Descartes 0.20 21.96
TUBB2B 0.0014050 984 GTEx DepMap Descartes 12.23 2119.02
STMN2 0.0011711 1289 GTEx DepMap Descartes 14.31 2558.61
SYNPO2 0.0010187 1514 GTEx DepMap Descartes 0.25 5.43
SLC44A5 0.0008963 1752 GTEx DepMap Descartes 0.05 3.87
MLLT11 0.0001174 4874 GTEx DepMap Descartes 4.24 550.62
RYR2 -0.0003917 8950 GTEx DepMap Descartes 0.07 1.22
EPHA6 -0.0004124 9098 GTEx DepMap Descartes 0.02 1.71
REEP1 -0.0004157 9122 GTEx DepMap Descartes 0.20 16.18
HS3ST5 -0.0004750 9470 GTEx DepMap Descartes 0.03 2.70
CNKSR2 -0.0005881 10037 GTEx DepMap Descartes 0.07 2.91
PTCHD1 -0.0007172 10595 GTEx DepMap Descartes 0.05 1.29
PLXNA4 -0.0009487 11272 GTEx DepMap Descartes 0.04 1.04
CNTFR -0.0010212 11440 GTEx DepMap Descartes 0.32 52.48
ANKFN1 -0.0010902 11583 GTEx DepMap Descartes 0.01 0.29
RBFOX1 -0.0011620 11691 GTEx DepMap Descartes 0.09 6.26
GREM1 -0.0012146 11771 GTEx DepMap Descartes 0.01 0.11
RGMB -0.0012362 11793 GTEx DepMap Descartes 0.19 12.97


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.61e-01
Mean rank of genes in gene set: 7310.63
Median rank of genes in gene set: 8081
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHRM3 0.0084036 7 GTEx DepMap Descartes 0.63 29.46
IRX3 0.0045079 87 GTEx DepMap Descartes 0.21 29.06
ARHGAP29 0.0018713 620 GTEx DepMap Descartes 0.23 9.23
HYAL2 0.0017106 732 GTEx DepMap Descartes 0.41 33.87
RAMP2 0.0008798 1775 GTEx DepMap Descartes 0.82 298.08
PTPRB 0.0004718 3064 GTEx DepMap Descartes 0.01 0.26
NPR1 0.0000128 5569 GTEx DepMap Descartes 0.00 0.20
SHANK3 -0.0001287 6784 GTEx DepMap Descartes 0.01 0.59
NOTCH4 -0.0001396 6887 GTEx DepMap Descartes 0.07 3.47
ID1 -0.0001416 6906 GTEx DepMap Descartes 0.14 34.66
PODXL -0.0001859 7301 GTEx DepMap Descartes 0.03 1.27
ESM1 -0.0002031 7465 GTEx DepMap Descartes 0.00 0.15
SLCO2A1 -0.0002052 7487 GTEx DepMap Descartes 0.00 0.03
BTNL9 -0.0002258 7655 GTEx DepMap Descartes 0.00 0.00
KDR -0.0002339 7732 GTEx DepMap Descartes 0.00 0.18
FLT4 -0.0002372 7763 GTEx DepMap Descartes 0.00 0.02
TEK -0.0002452 7832 GTEx DepMap Descartes 0.00 0.03
SHE -0.0002552 7924 GTEx DepMap Descartes 0.00 0.05
NR5A2 -0.0002569 7945 GTEx DepMap Descartes 0.00 0.00
KANK3 -0.0002906 8217 GTEx DepMap Descartes 0.00 0.37
PLVAP -0.0003285 8513 GTEx DepMap Descartes 0.01 0.59
CDH5 -0.0003334 8551 GTEx DepMap Descartes 0.00 0.09
RASIP1 -0.0003361 8576 GTEx DepMap Descartes 0.01 0.44
GALNT15 -0.0003432 8621 GTEx DepMap Descartes 0.00 NA
ROBO4 -0.0003529 8680 GTEx DepMap Descartes 0.00 0.15
TIE1 -0.0003530 8682 GTEx DepMap Descartes 0.00 0.09
EHD3 -0.0003660 8759 GTEx DepMap Descartes 0.01 0.67
TMEM88 -0.0003673 8769 GTEx DepMap Descartes 0.02 8.82
CRHBP -0.0003690 8779 GTEx DepMap Descartes 0.00 0.16
MMRN2 -0.0003853 8907 GTEx DepMap Descartes 0.00 0.03


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 7707.3
Median rank of genes in gene set: 8456
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PDGFRA 0.0061750 40 GTEx DepMap Descartes 0.50 26.80
PRICKLE1 0.0042086 98 GTEx DepMap Descartes 0.35 20.83
CDH11 0.0039407 121 GTEx DepMap Descartes 0.18 10.26
HHIP 0.0037916 130 GTEx DepMap Descartes 0.30 11.52
PCOLCE 0.0035913 149 GTEx DepMap Descartes 1.30 284.24
PCDH18 0.0001521 4660 GTEx DepMap Descartes 0.02 1.21
GAS2 0.0000640 5216 GTEx DepMap Descartes 0.01 1.36
COL27A1 -0.0000427 5965 GTEx DepMap Descartes 0.01 0.21
LRRC17 -0.0000439 5975 GTEx DepMap Descartes 0.01 1.69
ADAMTSL3 -0.0000754 6240 GTEx DepMap Descartes 0.00 0.09
C7 -0.0001749 7201 GTEx DepMap Descartes 0.02 0.85
SFRP2 -0.0001877 7319 GTEx DepMap Descartes 0.00 0.05
IGFBP3 -0.0002353 7750 GTEx DepMap Descartes 0.00 0.64
SCARA5 -0.0002377 7769 GTEx DepMap Descartes 0.00 0.00
ADAMTS2 -0.0002462 7848 GTEx DepMap Descartes 0.02 1.20
ACTA2 -0.0002656 8013 GTEx DepMap Descartes 0.07 15.29
RSPO3 -0.0002663 8018 GTEx DepMap Descartes 0.00 NA
GLI2 -0.0002953 8257 GTEx DepMap Descartes 0.00 0.00
ITGA11 -0.0003081 8363 GTEx DepMap Descartes 0.00 0.10
DKK2 -0.0003147 8414 GTEx DepMap Descartes 0.00 0.15
LAMC3 -0.0003154 8422 GTEx DepMap Descartes 0.00 0.00
ABCA6 -0.0003182 8440 GTEx DepMap Descartes 0.00 0.17
ABCC9 -0.0003229 8472 GTEx DepMap Descartes 0.00 0.01
EDNRA -0.0003486 8652 GTEx DepMap Descartes 0.01 0.15
LOX -0.0003899 8938 GTEx DepMap Descartes 0.03 0.96
PRRX1 -0.0003915 8947 GTEx DepMap Descartes 0.01 0.43
FREM1 -0.0003926 8957 GTEx DepMap Descartes 0.00 0.02
CCDC80 -0.0004585 9367 GTEx DepMap Descartes 0.03 0.47
MGP -0.0004638 9393 GTEx DepMap Descartes 0.02 1.06
PAMR1 -0.0004658 9407 GTEx DepMap Descartes 0.00 0.00


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.21e-01
Mean rank of genes in gene set: 7102.89
Median rank of genes in gene set: 8732
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCSK1N 0.0065333 30 GTEx DepMap Descartes 6.68 2378.48
C1QL1 0.0065047 31 GTEx DepMap Descartes 1.54 398.56
FGF14 0.0045343 84 GTEx DepMap Descartes 0.28 8.46
SORCS3 0.0033106 185 GTEx DepMap Descartes 0.09 7.10
FAM155A 0.0022304 457 GTEx DepMap Descartes 0.25 9.78
KCTD16 0.0020340 538 GTEx DepMap Descartes 0.38 10.03
DGKK 0.0013243 1066 GTEx DepMap Descartes 0.05 2.50
HTATSF1 0.0011263 1370 GTEx DepMap Descartes 0.57 63.86
NTNG1 0.0009971 1551 GTEx DepMap Descartes 0.13 7.97
CDH12 0.0008375 1872 GTEx DepMap Descartes 0.04 3.06
UNC80 0.0004960 2983 GTEx DepMap Descartes 0.14 3.81
TIAM1 0.0003593 3531 GTEx DepMap Descartes 0.14 6.02
PACRG 0.0001608 4613 GTEx DepMap Descartes 0.05 10.65
CNTN3 -0.0000586 6092 GTEx DepMap Descartes 0.00 0.28
SLC35F3 -0.0001143 6669 GTEx DepMap Descartes 0.00 0.24
PENK -0.0001166 6683 GTEx DepMap Descartes 0.00 1.15
GRM7 -0.0001800 7253 GTEx DepMap Descartes 0.00 0.16
KSR2 -0.0002112 7533 GTEx DepMap Descartes 0.04 0.86
CDH18 -0.0003454 8634 GTEx DepMap Descartes 0.00 0.24
CCSER1 -0.0003763 8830 GTEx DepMap Descartes 0.04 NA
GALNTL6 -0.0004877 9534 GTEx DepMap Descartes 0.02 2.04
ST18 -0.0005314 9773 GTEx DepMap Descartes 0.01 0.67
SLC24A2 -0.0005633 9933 GTEx DepMap Descartes 0.00 0.03
LAMA3 -0.0006445 10298 GTEx DepMap Descartes 0.00 0.02
TBX20 -0.0006749 10429 GTEx DepMap Descartes 0.00 0.00
CHGA -0.0007097 10564 GTEx DepMap Descartes 0.96 159.19
PCSK2 -0.0007448 10688 GTEx DepMap Descartes 0.01 0.41
ROBO1 -0.0007918 10840 GTEx DepMap Descartes 0.13 5.13
EML6 -0.0008623 11048 GTEx DepMap Descartes 0.01 0.25
SPOCK3 -0.0008649 11057 GTEx DepMap Descartes 0.02 2.38


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.68e-01
Mean rank of genes in gene set: 7523.28
Median rank of genes in gene set: 7876
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RAPGEF2 0.0010036 1540 GTEx DepMap Descartes 0.18 7.78
SPECC1 0.0007307 2178 GTEx DepMap Descartes 0.07 3.00
XPO7 0.0006453 2429 GTEx DepMap Descartes 0.13 9.38
TFR2 0.0005330 2853 GTEx DepMap Descartes 0.06 5.52
MARCH3 0.0004769 3046 GTEx DepMap Descartes 0.04 NA
GCLC 0.0003138 3758 GTEx DepMap Descartes 0.08 6.34
CAT 0.0002212 4269 GTEx DepMap Descartes 0.17 22.66
SLC25A21 0.0001763 4525 GTEx DepMap Descartes 0.00 0.03
SPTB 0.0001611 4611 GTEx DepMap Descartes 0.03 1.03
TMCC2 0.0000032 5626 GTEx DepMap Descartes 0.03 2.76
RHD -0.0001195 6703 GTEx DepMap Descartes 0.00 0.00
RGS6 -0.0001626 7092 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0002118 7545 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0002225 7631 GTEx DepMap Descartes 0.00 0.00
DENND4A -0.0002500 7876 GTEx DepMap Descartes 0.12 4.05
TRAK2 -0.0002938 8244 GTEx DepMap Descartes 0.06 2.57
SELENBP1 -0.0004018 9020 GTEx DepMap Descartes 0.00 0.05
EPB41 -0.0004023 9025 GTEx DepMap Descartes 0.22 11.88
CPOX -0.0004088 9074 GTEx DepMap Descartes 0.02 2.44
ANK1 -0.0004896 9545 GTEx DepMap Descartes 0.03 1.14
MICAL2 -0.0005012 9613 GTEx DepMap Descartes 0.01 0.34
TSPAN5 -0.0005741 9974 GTEx DepMap Descartes 0.31 25.27
FECH -0.0009262 11213 GTEx DepMap Descartes 0.04 1.41
BLVRB -0.0009639 11299 GTEx DepMap Descartes 0.19 35.85
SLC25A37 -0.0010431 11482 GTEx DepMap Descartes 0.18 10.62
ABCB10 -0.0010790 11559 GTEx DepMap Descartes 0.02 1.25
SOX6 -0.0013674 11958 GTEx DepMap Descartes 0.01 0.14
SNCA -0.0015245 12104 GTEx DepMap Descartes 0.14 12.10
GYPC -0.0021126 12383 GTEx DepMap Descartes 0.05 5.02
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9902.55
Median rank of genes in gene set: 10976
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ITPR2 0.0022133 465 GTEx DepMap Descartes 0.21 5.44
RBPJ 0.0010153 1519 GTEx DepMap Descartes 0.71 38.83
HRH1 0.0002501 4110 GTEx DepMap Descartes 0.01 1.11
SFMBT2 -0.0000187 5773 GTEx DepMap Descartes 0.03 1.15
RGL1 -0.0001328 6818 GTEx DepMap Descartes 0.03 1.64
MARCH1 -0.0002488 7865 GTEx DepMap Descartes 0.06 NA
WWP1 -0.0003093 8372 GTEx DepMap Descartes 0.06 3.53
ATP8B4 -0.0004477 9306 GTEx DepMap Descartes 0.00 0.14
FGD2 -0.0004857 9519 GTEx DepMap Descartes 0.00 0.17
SLC9A9 -0.0005472 9849 GTEx DepMap Descartes 0.01 0.52
MERTK -0.0005524 9872 GTEx DepMap Descartes 0.01 0.85
SPP1 -0.0005920 10061 GTEx DepMap Descartes 10.32 1461.94
CST3 -0.0006230 10208 GTEx DepMap Descartes 1.56 153.61
ABCA1 -0.0006611 10374 GTEx DepMap Descartes 0.07 1.71
SLC1A3 -0.0007116 10573 GTEx DepMap Descartes 0.01 0.53
CD163 -0.0007181 10598 GTEx DepMap Descartes 0.06 2.97
SLCO2B1 -0.0007366 10657 GTEx DepMap Descartes 0.03 0.98
CPVL -0.0007922 10842 GTEx DepMap Descartes 0.03 3.08
LGMN -0.0007936 10846 GTEx DepMap Descartes 0.26 34.25
MS4A4A -0.0008878 11106 GTEx DepMap Descartes 0.06 8.49
HCK -0.0008960 11127 GTEx DepMap Descartes 0.01 1.06
CSF1R -0.0009185 11185 GTEx DepMap Descartes 0.02 1.18
ADAP2 -0.0009193 11191 GTEx DepMap Descartes 0.03 3.12
AXL -0.0009204 11195 GTEx DepMap Descartes 0.02 0.62
FGL2 -0.0009260 11212 GTEx DepMap Descartes 0.02 1.08
PTPRE -0.0009288 11220 GTEx DepMap Descartes 0.04 1.85
MSR1 -0.0009303 11224 GTEx DepMap Descartes 0.04 2.23
CTSB -0.0009434 11260 GTEx DepMap Descartes 1.22 85.06
IFNGR1 -0.0009603 11294 GTEx DepMap Descartes 0.13 16.58
CD14 -0.0009654 11302 GTEx DepMap Descartes 0.31 45.12


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8159.09
Median rank of genes in gene set: 9501
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ERBB4 0.0070309 22 GTEx DepMap Descartes 0.25 9.41
VCAN 0.0029262 245 GTEx DepMap Descartes 0.81 21.06
SOX5 0.0026376 309 GTEx DepMap Descartes 0.23 12.97
MARCKS 0.0023937 390 GTEx DepMap Descartes 5.59 419.05
PLCE1 0.0020573 531 GTEx DepMap Descartes 0.11 3.07
NRXN1 0.0017564 700 GTEx DepMap Descartes 0.84 27.68
IL1RAPL1 0.0008955 1754 GTEx DepMap Descartes 0.02 1.78
SLC35F1 0.0004171 3279 GTEx DepMap Descartes 0.06 2.69
FIGN 0.0002697 3988 GTEx DepMap Descartes 0.12 3.83
ADAMTS5 0.0000365 5413 GTEx DepMap Descartes 0.02 0.54
NRXN3 -0.0000375 5926 GTEx DepMap Descartes 0.01 0.41
MDGA2 -0.0000529 6040 GTEx DepMap Descartes 0.00 0.04
IL1RAPL2 -0.0000893 6388 GTEx DepMap Descartes 0.00 0.00
HMGA2 -0.0001505 6984 GTEx DepMap Descartes 0.00 0.01
XKR4 -0.0001918 7367 GTEx DepMap Descartes 0.01 0.25
PTPRZ1 -0.0002250 7645 GTEx DepMap Descartes 0.00 0.07
MPZ -0.0002906 8219 GTEx DepMap Descartes 0.01 2.80
TRPM3 -0.0003467 8640 GTEx DepMap Descartes 0.00 0.07
OLFML2A -0.0004284 9193 GTEx DepMap Descartes 0.00 0.02
EDNRB -0.0004559 9355 GTEx DepMap Descartes 0.01 0.34
PPP2R2B -0.0004670 9418 GTEx DepMap Descartes 0.32 7.54
PLP1 -0.0004769 9479 GTEx DepMap Descartes 0.00 0.49
COL25A1 -0.0004860 9523 GTEx DepMap Descartes 0.01 0.39
ERBB3 -0.0005243 9733 GTEx DepMap Descartes 0.00 0.02
STARD13 -0.0006022 10104 GTEx DepMap Descartes 0.01 0.43
SORCS1 -0.0006581 10363 GTEx DepMap Descartes 0.04 1.72
COL5A2 -0.0006620 10378 GTEx DepMap Descartes 0.02 0.43
DST -0.0006667 10395 GTEx DepMap Descartes 0.93 13.30
LRRTM4 -0.0006747 10427 GTEx DepMap Descartes 0.01 0.65
LAMC1 -0.0006922 10498 GTEx DepMap Descartes 0.02 0.70


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9104.16
Median rank of genes in gene set: 10147
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DOK6 0.0021972 472 GTEx DepMap Descartes 0.15 5.86
HIPK2 0.0011369 1351 GTEx DepMap Descartes 0.33 6.86
PRKAR2B 0.0008092 1943 GTEx DepMap Descartes 0.34 31.08
TPM4 0.0003326 3651 GTEx DepMap Descartes 1.06 65.16
MED12L 0.0002383 4177 GTEx DepMap Descartes 0.03 0.91
SLC24A3 0.0001093 4929 GTEx DepMap Descartes 0.00 0.39
ITGA2B 0.0000290 5455 GTEx DepMap Descartes 0.01 1.05
ACTB -0.0001624 7088 GTEx DepMap Descartes 15.94 2256.13
TRPC6 -0.0002033 7469 GTEx DepMap Descartes 0.00 0.02
VCL -0.0002340 7735 GTEx DepMap Descartes 0.08 2.60
MMRN1 -0.0002447 7826 GTEx DepMap Descartes 0.00 0.00
GP1BA -0.0002541 7913 GTEx DepMap Descartes 0.00 0.00
ITGB3 -0.0002580 7955 GTEx DepMap Descartes 0.00 0.00
ARHGAP6 -0.0002587 7960 GTEx DepMap Descartes 0.00 0.06
TUBB1 -0.0002827 8165 GTEx DepMap Descartes 0.00 0.00
PDE3A -0.0003146 8410 GTEx DepMap Descartes 0.03 1.34
LTBP1 -0.0003361 8575 GTEx DepMap Descartes 0.01 0.28
P2RX1 -0.0003525 8677 GTEx DepMap Descartes 0.00 0.08
PSTPIP2 -0.0004271 9183 GTEx DepMap Descartes 0.01 0.70
FLNA -0.0004311 9207 GTEx DepMap Descartes 0.19 6.76
MYLK -0.0005401 9813 GTEx DepMap Descartes 0.01 0.07
MCTP1 -0.0005655 9943 GTEx DepMap Descartes 0.01 0.25
ANGPT1 -0.0006100 10147 GTEx DepMap Descartes 0.02 0.55
RAB27B -0.0006468 10312 GTEx DepMap Descartes 0.01 0.49
THBS1 -0.0006924 10500 GTEx DepMap Descartes 0.02 0.52
UBASH3B -0.0007094 10561 GTEx DepMap Descartes 0.01 0.58
STON2 -0.0007104 10569 GTEx DepMap Descartes 0.03 2.29
FLI1 -0.0007885 10835 GTEx DepMap Descartes 0.00 0.18
RAP1B -0.0008202 10932 GTEx DepMap Descartes 0.45 10.35
TLN1 -0.0008866 11100 GTEx DepMap Descartes 0.11 4.00


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9750.6
Median rank of genes in gene set: 11509.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TOX 0.0021961 473 GTEx DepMap Descartes 0.39 30.09
EVL 0.0017754 685 GTEx DepMap Descartes 1.53 135.36
BCL2 0.0017203 722 GTEx DepMap Descartes 0.35 16.98
ABLIM1 0.0012096 1241 GTEx DepMap Descartes 0.19 8.66
TMSB10 0.0010289 1500 GTEx DepMap Descartes 37.18 26065.15
PITPNC1 0.0008738 1791 GTEx DepMap Descartes 0.19 10.33
BACH2 0.0000570 5260 GTEx DepMap Descartes 0.10 3.75
GNG2 -0.0001160 6677 GTEx DepMap Descartes 0.37 34.51
MCTP2 -0.0002780 8130 GTEx DepMap Descartes 0.01 0.44
PDE3B -0.0004600 9376 GTEx DepMap Descartes 0.10 5.37
ITPKB -0.0007577 10733 GTEx DepMap Descartes 0.00 0.14
PLEKHA2 -0.0007622 10747 GTEx DepMap Descartes 0.01 0.77
ARID5B -0.0007717 10770 GTEx DepMap Descartes 0.13 4.72
SAMD3 -0.0007755 10785 GTEx DepMap Descartes 0.00 0.20
ANKRD44 -0.0007871 10827 GTEx DepMap Descartes 0.07 2.88
NCALD -0.0007940 10849 GTEx DepMap Descartes 0.05 3.76
CCL5 -0.0009080 11160 GTEx DepMap Descartes 0.02 6.79
SORL1 -0.0009408 11252 GTEx DepMap Descartes 0.09 2.83
SCML4 -0.0009976 11388 GTEx DepMap Descartes 0.02 1.45
STK39 -0.0010001 11394 GTEx DepMap Descartes 0.15 13.12
SKAP1 -0.0010483 11492 GTEx DepMap Descartes 0.00 0.44
PRKCH -0.0010663 11527 GTEx DepMap Descartes 0.00 0.39
RCSD1 -0.0011152 11620 GTEx DepMap Descartes 0.01 0.27
DOCK10 -0.0011284 11638 GTEx DepMap Descartes 0.02 0.99
IKZF1 -0.0011493 11670 GTEx DepMap Descartes 0.01 0.43
FYN -0.0011792 11719 GTEx DepMap Descartes 0.60 52.71
FOXP1 -0.0012346 11791 GTEx DepMap Descartes 0.57 19.22
LEF1 -0.0012571 11824 GTEx DepMap Descartes 0.00 0.12
ARHGAP15 -0.0012959 11868 GTEx DepMap Descartes 0.01 0.34
ETS1 -0.0012984 11871 GTEx DepMap Descartes 0.00 0.12


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.33e-02
Mean rank of genes in gene set: 594.5
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRDX2 0.0073926 19 GTEx DepMap Descartes 6.92 1330.39
KCNH2 0.0012511 1170 GTEx DepMap Descartes 0.18 14.29


B-cell lineage: Large pre-B cells (curated markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.55e-02
Mean rank of genes in gene set: 752.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MKI67 0.0022350 456 GTEx DepMap Descartes 1.04 27.88
MME 0.0013427 1049 GTEx DepMap Descartes 0.04 3.67


HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.26e-02
Mean rank of genes in gene set: 41
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CKB 0.0061598 41 GTEx DepMap Descartes 6.12 1414.9