Program: 1. Endothelial.

Program: 1. Endothelial.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 AQP1 0.0063710 aquaporin 1 (Colton blood group) GTEx DepMap Descartes 4.06 268.49
2 EMCN 0.0061704 endomucin GTEx DepMap Descartes 1.84 103.25
3 INHBB 0.0060883 inhibin subunit beta B GTEx DepMap Descartes 0.71 45.75
4 ESAM 0.0057671 endothelial cell adhesion molecule GTEx DepMap Descartes 2.95 265.73
5 PLVAP 0.0056084 plasmalemma vesicle associated protein GTEx DepMap Descartes 8.02 662.01
6 CLEC14A 0.0053500 C-type lectin domain containing 14A GTEx DepMap Descartes 3.20 326.98
7 CDH5 0.0053446 cadherin 5 GTEx DepMap Descartes 2.27 107.02
8 HSPG2 0.0053289 heparan sulfate proteoglycan 2 GTEx DepMap Descartes 7.60 100.02
9 FAM167B 0.0052863 family with sequence similarity 167 member B GTEx DepMap Descartes 3.07 728.95
10 BCAM 0.0050582 basal cell adhesion molecule (Lutheran blood group) GTEx DepMap Descartes 2.24 132.00
11 DLL4 0.0050499 delta like canonical Notch ligand 4 GTEx DepMap Descartes 0.83 39.52
12 KDR 0.0050336 kinase insert domain receptor GTEx DepMap Descartes 2.01 63.87
13 FLT1 0.0049599 fms related receptor tyrosine kinase 1 GTEx DepMap Descartes 2.91 74.63
14 MMRN2 0.0048994 multimerin 2 GTEx DepMap Descartes 1.27 60.96
15 EGFL7 0.0048722 EGF like domain multiple 7 GTEx DepMap Descartes 6.10 606.76
16 CD34 0.0048429 CD34 molecule GTEx DepMap Descartes 3.22 79.45
17 ENG 0.0047893 endoglin GTEx DepMap Descartes 6.87 458.40
18 GJA1 0.0047114 gap junction protein alpha 1 GTEx DepMap Descartes 1.73 95.14
19 A2M 0.0046635 alpha-2-macroglobulin GTEx DepMap Descartes 10.26 448.67
20 CLDN5 0.0046273 claudin 5 GTEx DepMap Descartes 5.81 473.58
21 VWF 0.0045265 von Willebrand factor GTEx DepMap Descartes 8.28 195.57
22 TM4SF1 0.0043025 transmembrane 4 L six family member 1 GTEx DepMap Descartes 4.83 374.45
23 NOSTRIN 0.0042974 nitric oxide synthase trafficking GTEx DepMap Descartes 0.96 96.87
24 STC1 0.0042510 stanniocalcin 1 GTEx DepMap Descartes 1.24 55.89
25 ROBO4 0.0041193 roundabout guidance receptor 4 GTEx DepMap Descartes 1.42 69.04
26 SPRY1 0.0040182 sprouty RTK signaling antagonist 1 GTEx DepMap Descartes 4.08 346.34
27 PALMD 0.0039698 palmdelphin GTEx DepMap Descartes 1.06 46.59
28 SPARCL1 0.0039332 SPARC like 1 GTEx DepMap Descartes 10.67 834.11
29 CYYR1 0.0039245 cysteine and tyrosine rich 1 GTEx DepMap Descartes 1.29 81.88
30 ABCG2 0.0038371 ATP binding cassette subfamily G member 2 (Junior blood group) GTEx DepMap Descartes 0.39 18.51
31 HTRA1 0.0038119 HtrA serine peptidase 1 GTEx DepMap Descartes 3.36 282.83
32 COL15A1 0.0037882 collagen type XV alpha 1 chain GTEx DepMap Descartes 3.74 126.71
33 PODXL 0.0037162 podocalyxin like GTEx DepMap Descartes 2.71 82.46
34 SLC9A3R2 0.0036795 SLC9A3 regulator 2 GTEx DepMap Descartes 4.75 442.99
35 FAM107A 0.0036241 family with sequence similarity 107 member A GTEx DepMap Descartes 0.23 12.81
36 MECOM 0.0036083 MDS1 and EVI1 complex locus GTEx DepMap Descartes 0.63 22.26
37 GPR4 0.0035979 G protein-coupled receptor 4 GTEx DepMap Descartes 0.60 36.20
38 CALCRL 0.0035825 calcitonin receptor like receptor GTEx DepMap Descartes 1.59 60.20
39 INSR 0.0035578 insulin receptor GTEx DepMap Descartes 4.33 85.30
40 ACKR3 0.0035200 atypical chemokine receptor 3 GTEx DepMap Descartes 0.74 NA
41 RBP7 0.0035102 retinol binding protein 7 GTEx DepMap Descartes 1.98 437.84
42 SPARC 0.0034766 secreted protein acidic and cysteine rich GTEx DepMap Descartes 27.05 1402.52
43 NR5A2 0.0034462 nuclear receptor subfamily 5 group A member 2 GTEx DepMap Descartes 0.14 4.97
44 TIE1 0.0034401 tyrosine kinase with immunoglobulin like and EGF like domains 1 GTEx DepMap Descartes 1.04 57.16
45 PREX2 0.0034156 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 GTEx DepMap Descartes 0.60 12.20
46 PCDH12 0.0034119 protocadherin 12 GTEx DepMap Descartes 1.03 29.95
47 ERG 0.0034080 ETS transcription factor ERG GTEx DepMap Descartes 0.67 NA
48 IGFBP3 0.0034010 insulin like growth factor binding protein 3 GTEx DepMap Descartes 4.22 311.68
49 ESM1 0.0033963 endothelial cell specific molecule 1 GTEx DepMap Descartes 2.05 177.79
50 PTPRB 0.0033957 protein tyrosine phosphatase receptor type B GTEx DepMap Descartes 1.14 17.94


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UMAP plots showing activity of gene expression program identified in GEP 1. Endothelial:

Interactive UMAP Plot
Interactive UMAP Plot
Interactive UMAP Plot
Interactive Boxplot
Interactive Boxplot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_PERICYTES 1.04e-36 171.85 88.15 3.50e-34 6.99e-34
22AQP1, EMCN, ESAM, PLVAP, CLEC14A, FLT1, EGFL7, CD34, ENG, A2M, CLDN5, VWF, TM4SF1, NOSTRIN, SPRY1, PALMD, SPARCL1, CYYR1, ABCG2, PODXL, SLC9A3R2, CALCRL
 79
DESCARTES_FETAL_INTESTINE_VASCULAR_ENDOTHELIAL_CELLS 1.32e-26 190.01 86.63 7.37e-25 8.84e-24
15EMCN, ESAM, PLVAP, CLEC14A, HSPG2, FAM167B, DLL4, FLT1, MMRN2, CD34, CYYR1, COL15A1, GPR4, PCDH12, ESM1
 43
AIZARANI_LIVER_C10_MVECS_1 3.30e-48 124.68 65.23 2.21e-45 2.21e-45
35AQP1, EMCN, ESAM, PLVAP, CLEC14A, CDH5, BCAM, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, GJA1, A2M, CLDN5, VWF, TM4SF1, NOSTRIN, ROBO4, SPRY1, PALMD, SPARCL1, CYYR1, COL15A1, SLC9A3R2, FAM107A, CALCRL, INSR, RBP7, SPARC, TIE1, PCDH12, ERG, PTPRB
 269
GAO_LARGE_INTESTINE_24W_C2_MKI67POS_PROGENITOR 6.83e-33 107.59 56.52 7.64e-31 4.58e-30
22EMCN, ESAM, PLVAP, CLEC14A, CDH5, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, CLDN5, VWF, TM4SF1, ROBO4, PALMD, CYYR1, PODXL, CALCRL, TIE1, ERG, PTPRB
 113
DESCARTES_FETAL_STOMACH_VASCULAR_ENDOTHELIAL_CELLS 1.56e-15 130.42 49.28 4.54e-14 1.04e-12
9EMCN, ESAM, PLVAP, CLEC14A, FLT1, CD34, A2M, CYYR1, PCDH12
 30
CUI_DEVELOPING_HEART_C4_ENDOTHELIAL_CELL 2.84e-30 79.09 41.93 2.39e-28 1.91e-27
22EMCN, ESAM, PLVAP, CLEC14A, CDH5, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, VWF, TM4SF1, NOSTRIN, ROBO4, PALMD, CYYR1, PODXL, CALCRL, ACKR3, TIE1, PTPRB
 146
DESCARTES_FETAL_PANCREAS_VASCULAR_ENDOTHELIAL_CELLS 1.24e-19 86.05 39.45 4.63e-18 8.34e-17
13ESAM, PLVAP, CLEC14A, HSPG2, FAM167B, FLT1, MMRN2, CD34, NOSTRIN, CYYR1, COL15A1, PCDH12, ESM1
 64
RUBENSTEIN_SKELETAL_MUSCLE_ENDOTHELIAL_CELLS 3.98e-27 71.12 37.16 2.96e-25 2.67e-24
20AQP1, EMCN, ESAM, CLEC14A, CDH5, HSPG2, FLT1, MMRN2, EGFL7, CD34, ENG, A2M, CLDN5, VWF, TM4SF1, PALMD, SPARCL1, PODXL, SLC9A3R2, PTPRB
 137
DESCARTES_FETAL_ADRENAL_VASCULAR_ENDOTHELIAL_CELLS 5.39e-27 69.97 36.55 3.29e-25 3.62e-24
20INHBB, PLVAP, CLEC14A, CDH5, DLL4, KDR, MMRN2, CD34, ENG, CLDN5, ROBO4, PODXL, SLC9A3R2, GPR4, CALCRL, NR5A2, TIE1, PCDH12, ESM1, PTPRB
 139
AIZARANI_LIVER_C29_MVECS_2 2.91e-36 66.23 35.95 6.51e-34 1.95e-33
30AQP1, EMCN, ESAM, PLVAP, CLEC14A, CDH5, FLT1, MMRN2, CD34, ENG, GJA1, A2M, CLDN5, VWF, TM4SF1, STC1, SPRY1, PALMD, SPARCL1, CYYR1, FAM107A, MECOM, CALCRL, INSR, ACKR3, TIE1, PREX2, ERG, IGFBP3, PTPRB
 313
DESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS 7.36e-24 62.24 31.85 3.09e-22 4.94e-21
18EMCN, PLVAP, BCAM, KDR, FLT1, EGFL7, A2M, CLDN5, VWF, PALMD, COL15A1, PODXL, MECOM, CALCRL, TIE1, PREX2, ERG, PTPRB
 131
DESCARTES_FETAL_EYE_VASCULAR_ENDOTHELIAL_CELLS 2.29e-19 63.83 30.49 8.08e-18 1.54e-16
14PLVAP, CLEC14A, CDH5, FLT1, EGFL7, ENG, CLDN5, VWF, ROBO4, ABCG2, PODXL, CALCRL, TIE1, ERG
 90
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_1 1.58e-33 49.91 27.08 2.25e-31 1.06e-30
31EMCN, ESAM, CLEC14A, CDH5, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, GJA1, CLDN5, VWF, TM4SF1, NOSTRIN, ROBO4, PALMD, SPARCL1, CYYR1, PODXL, SLC9A3R2, MECOM, CALCRL, INSR, SPARC, TIE1, PREX2, PCDH12, ERG, PTPRB
 440
MURARO_PANCREAS_ENDOTHELIAL_CELL 6.17e-31 47.73 26.00 5.91e-29 4.14e-28
28EMCN, ESAM, PLVAP, CLEC14A, CDH5, KDR, FLT1, MMRN2, CD34, A2M, VWF, TM4SF1, STC1, ROBO4, SPARCL1, CYYR1, HTRA1, COL15A1, PODXL, MECOM, GPR4, CALCRL, INSR, SPARC, TIE1, ERG, ESM1, PTPRB
 362
AIZARANI_LIVER_C13_LSECS_2 4.79e-27 44.56 24.14 3.22e-25 3.22e-24
24EMCN, ESAM, CLEC14A, CDH5, FAM167B, KDR, FLT1, MMRN2, EGFL7, ENG, A2M, CLDN5, TM4SF1, NOSTRIN, ROBO4, SLC9A3R2, FAM107A, CALCRL, INSR, SPARC, TIE1, PREX2, ERG, PTPRB
 283
MANNO_MIDBRAIN_NEUROTYPES_HENDO 1.68e-33 41.87 21.67 2.25e-31 1.13e-30
37EMCN, ESAM, PLVAP, CLEC14A, CDH5, HSPG2, BCAM, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, GJA1, A2M, CLDN5, VWF, TM4SF1, NOSTRIN, ROBO4, PALMD, CYYR1, ABCG2, HTRA1, PODXL, SLC9A3R2, MECOM, GPR4, CALCRL, INSR, TIE1, PCDH12, ERG, IGFBP3, ESM1, PTPRB
 888
DESCARTES_FETAL_MUSCLE_VASCULAR_ENDOTHELIAL_CELLS 1.89e-13 49.55 21.14 4.69e-12 1.27e-10
10PLVAP, FAM167B, DLL4, FLT1, MMRN2, TM4SF1, NOSTRIN, CYYR1, RBP7, ESM1
 73
MENON_FETAL_KIDNEY_9_ENDOTHELIAL_CELLS 3.66e-15 43.75 20.15 9.81e-14 2.45e-12
12EMCN, ESAM, HSPG2, KDR, FLT1, EGFL7, CD34, A2M, CLDN5, TM4SF1, NOSTRIN, SPARC
 102
DESCARTES_FETAL_PLACENTA_VASCULAR_ENDOTHELIAL_CELLS 3.66e-15 43.75 20.15 9.81e-14 2.45e-12
12PLVAP, CLEC14A, CDH5, DLL4, KDR, EGFL7, CD34, CLDN5, ROBO4, CYYR1, TIE1, ERG
 102
FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL 1.98e-24 33.85 18.40 9.50e-23 1.33e-21
24EMCN, ESAM, CLEC14A, CDH5, KDR, FLT1, EGFL7, CD34, ENG, CLDN5, VWF, TM4SF1, NOSTRIN, ROBO4, CYYR1, ABCG2, PODXL, SLC9A3R2, MECOM, SPARC, TIE1, PCDH12, ERG, PTPRB
 365

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_COAGULATION 2.09e-03 8.11 2.09 1.05e-01 1.05e-01
4A2M, VWF, HTRA1, SPARC
 138
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 7.71e-03 5.55 1.44 1.28e-01 3.85e-01
4GJA1, HTRA1, SPARC, IGFBP3
 200
HALLMARK_KRAS_SIGNALING_UP 7.71e-03 5.55 1.44 1.28e-01 3.85e-01
4PLVAP, ENG, SPARCL1, IGFBP3
 200
HALLMARK_HYPOXIA 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3STC1, ACKR3, IGFBP3
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3INHBB, GJA1, PODXL
 200
HALLMARK_MYOGENESIS 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3COL15A1, SPARC, IGFBP3
 200
HALLMARK_APICAL_JUNCTION 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3CD34, CLDN5, VWF
 200
HALLMARK_ADIPOGENESIS 1.85e-01 2.63 0.31 7.44e-01 1.00e+00
2SPARCL1, COL15A1
 200
HALLMARK_GLYCOLYSIS 1.85e-01 2.63 0.31 7.44e-01 1.00e+00
2STC1, IGFBP3
 200
HALLMARK_P53_PATHWAY 1.85e-01 2.63 0.31 7.44e-01 1.00e+00
2INHBB, TM4SF1
 200
HALLMARK_HEME_METABOLISM 1.85e-01 2.63 0.31 7.44e-01 1.00e+00
2BCAM, ABCG2
 200
HALLMARK_ANGIOGENESIS 1.34e-01 7.29 0.18 7.44e-01 1.00e+00
1STC1
 36
HALLMARK_TGF_BETA_SIGNALING 1.94e-01 4.81 0.12 7.44e-01 1.00e+00
1ENG
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1A2M
 87
HALLMARK_UV_RESPONSE_DN 4.35e-01 1.78 0.04 1.00e+00 1.00e+00
1GJA1
 144
HALLMARK_DNA_REPAIR 4.49e-01 1.71 0.04 1.00e+00 1.00e+00
1BCAM
 150
HALLMARK_TNFA_SIGNALING_VIA_NFKB 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ACKR3
 200
HALLMARK_MTORC1_SIGNALING 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1STC1
 200
HALLMARK_INFLAMMATORY_RESPONSE 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CALCRL
 200
HALLMARK_ALLOGRAFT_REJECTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1INHBB
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_CELL_ADHESION_MOLECULES_CAMS 1.83e-03 8.43 2.17 3.41e-01 3.41e-01
4ESAM, CDH5, CD34, CLDN5
 133
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 1.20e-02 13.01 1.48 7.46e-01 1.00e+00
2SLC9A3R2, INSR
 42
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.07e-02 7.06 1.39 7.46e-01 1.00e+00
3ESAM, CDH5, CLDN5
 116
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 3.05e-02 7.77 0.90 1.00e+00 1.00e+00
2A2M, VWF
 69
KEGG_ADHERENS_JUNCTION 3.38e-02 7.33 0.85 1.00e+00 1.00e+00
2INSR, PTPRB
 73
KEGG_FOCAL_ADHESION 4.30e-02 4.07 0.80 1.00e+00 1.00e+00
3KDR, FLT1, VWF
 199
KEGG_ECM_RECEPTOR_INTERACTION 4.36e-02 6.35 0.74 1.00e+00 1.00e+00
2HSPG2, VWF
 84
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 8.44e-02 3.05 0.60 1.00e+00 1.00e+00
3INHBB, KDR, FLT1
 265
KEGG_ENDOCYTOSIS 1.59e-01 2.91 0.34 1.00e+00 1.00e+00
2KDR, FLT1
 181
KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 8.77e-02 11.59 0.28 1.00e+00 1.00e+00
1AQP1
 23
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 9.49e-02 10.62 0.25 1.00e+00 1.00e+00
1NR5A2
 25
KEGG_ABC_TRANSPORTERS 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1ABCG2
 44
KEGG_NOTCH_SIGNALING_PATHWAY 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1DLL4
 47
KEGG_TYPE_II_DIABETES_MELLITUS 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1INSR
 47
KEGG_P53_SIGNALING_PATHWAY 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1IGFBP3
 68
KEGG_CHRONIC_MYELOID_LEUKEMIA 2.52e-01 3.54 0.09 1.00e+00 1.00e+00
1MECOM
 73
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1GJA1
 74
KEGG_VEGF_SIGNALING_PATHWAY 2.61e-01 3.40 0.08 1.00e+00 1.00e+00
1KDR
 76
KEGG_TGF_BETA_SIGNALING_PATHWAY 2.90e-01 3.00 0.07 1.00e+00 1.00e+00
1INHBB
 86
KEGG_HEMATOPOIETIC_CELL_LINEAGE 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1CD34
 87

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr4q22 3.13e-02 7.66 0.88 1.00e+00 1.00e+00
2SPARCL1, ABCG2
 70
chr11q24 1.61e-01 2.88 0.34 1.00e+00 1.00e+00
2ESAM, ROBO4
 183
chr1q32 2.78e-01 1.97 0.23 1.00e+00 1.00e+00
2CD34, NR5A2
 266
chr9q34 3.42e-01 1.69 0.20 1.00e+00 1.00e+00
2EGFL7, ENG
 311
chr12p13 3.72e-01 1.57 0.18 1.00e+00 1.00e+00
2A2M, VWF
 333
chr12q15 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1PTPRB
 55
chr4q24 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1EMCN
 56
chr7p12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1IGFBP3
 58
chr1p36 1.00e+00 0.80 0.09 1.00e+00 1.00e+00
2HSPG2, RBP7
 656
chr8q13 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1PREX2
 71
chr16q21 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1CDH5
 74
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1KDR
 79
chr19p13 1.00e+00 0.68 0.08 1.00e+00 1.00e+00
2PLVAP, INSR
 773
chr5q11 2.87e-01 3.04 0.07 1.00e+00 1.00e+00
1ESM1
 85
chr7q32 3.01e-01 2.87 0.07 1.00e+00 1.00e+00
1PODXL
 90
chr14q21 3.04e-01 2.83 0.07 1.00e+00 1.00e+00
1CLEC14A
 91
chr1p21 3.25e-01 2.60 0.06 1.00e+00 1.00e+00
1PALMD
 99
chr2q32 3.49e-01 2.38 0.06 1.00e+00 1.00e+00
1CALCRL
 108
chr5q33 3.52e-01 2.36 0.06 1.00e+00 1.00e+00
1SPARC
 109
chr21q21 3.77e-01 2.16 0.05 1.00e+00 1.00e+00
1CYYR1
 119

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
NFAT_Q6 4.75e-05 8.41 3.16 5.38e-02 5.38e-02
7HSPG2, DLL4, SPARCL1, PREX2, PCDH12, ERG, IGFBP3
 249
HP1SITEFACTOR_Q6 2.92e-04 7.44 2.57 1.66e-01 3.31e-01
6STC1, MECOM, CALCRL, SPARC, NR5A2, PREX2
 235
GATA3_01 2.60e-03 5.79 1.78 3.54e-01 1.00e+00
5INHBB, HSPG2, CD34, NR5A2, ERG
 245
CIZ_01 3.02e-03 5.58 1.71 3.54e-01 1.00e+00
5ACKR3, NR5A2, PCDH12, ERG, ESM1
 254
RYTTCCTG_ETS2_B 5.29e-04 3.59 1.70 2.00e-01 6.00e-01
12ESAM, CLEC14A, CDH5, DLL4, FLT1, EGFL7, CLDN5, NOSTRIN, ROBO4, CALCRL, SPARC, ERG
 1112
STAT5A_03 4.15e-03 5.16 1.59 3.80e-01 1.00e+00
5EMCN, HSPG2, FLT1, STC1, TIE1
 274
TGTTTGY_HNF3_Q6 1.68e-03 3.71 1.58 3.18e-01 1.00e+00
9EMCN, ESAM, MMRN2, EGFL7, A2M, ROBO4, SPRY1, PALMD, ERG
 748
ETS2_B 4.61e-03 5.03 1.55 3.80e-01 1.00e+00
5ESAM, CLEC14A, CDH5, SPARC, ESM1
 281
GATA1_05 4.81e-03 4.98 1.53 3.80e-01 1.00e+00
5EGFL7, STC1, MECOM, NR5A2, ERG
 284
GATAAGR_GATA_C 5.94e-03 4.72 1.45 3.96e-01 1.00e+00
5CD34, STC1, MECOM, NR5A2, ERG
 299
AACTTT_UNKNOWN 5.37e-03 2.54 1.26 3.80e-01 1.00e+00
14AQP1, EMCN, CDH5, HSPG2, CD34, GJA1, STC1, SPRY1, SPARCL1, MECOM, ACKR3, SPARC, NR5A2, ERG
 1928
VDR_Q3 1.27e-02 4.77 1.24 4.03e-01 1.00e+00
4BCAM, STC1, MECOM, GPR4
 232
SOX9_B1 1.38e-02 4.65 1.20 4.03e-01 1.00e+00
4HSPG2, STC1, PCDH12, ERG
 238
GCM_Q2 1.52e-02 4.51 1.17 4.03e-01 1.00e+00
4BCAM, DLL4, VWF, STC1
 245
RGAGGAARY_PU1_Q6 1.33e-02 3.35 1.16 4.03e-01 1.00e+00
6EMCN, PLVAP, MMRN2, NOSTRIN, TIE1, ESM1
 515
ELF1_Q6 1.60e-02 4.44 1.15 4.03e-01 1.00e+00
4CDH5, CALCRL, TIE1, ESM1
 249
GATA4_Q3 1.69e-02 4.37 1.13 4.03e-01 1.00e+00
4DLL4, EGFL7, STC1, COL15A1
 253
HMGIY_Q6 1.69e-02 4.37 1.13 4.03e-01 1.00e+00
4HSPG2, CALCRL, ERG, ESM1
 253
NERF_Q2 1.71e-02 4.35 1.13 4.03e-01 1.00e+00
4FLT1, MMRN2, ROBO4, ERG
 254
STAT5B_01 1.73e-02 4.33 1.12 4.03e-01 1.00e+00
4DLL4, CLDN5, STC1, ERG
 255

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_2_SIGNALING_PATHWAY 1.54e-04 172.68 14.09 3.72e-02 1.00e+00
2CLEC14A, KDR
 5
GOBP_ENDOTHELIUM_DEVELOPMENT 4.05e-12 27.95 12.61 4.33e-09 3.03e-08
11CDH5, DLL4, KDR, CD34, ENG, GJA1, CLDN5, STC1, ROBO4, COL15A1, TIE1
 137
GOBP_GLOMERULAR_MESANGIAL_CELL_DIFFERENTIATION 2.31e-04 129.66 11.45 4.80e-02 1.00e+00
2CD34, GPR4
 6
GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT 2.31e-04 129.66 11.45 4.80e-02 1.00e+00
2CDH5, CLDN5
 6
GOBP_NEGATIVE_REGULATION_OF_GONADOTROPIN_SECRETION 3.22e-04 103.49 9.64 5.77e-02 1.00e+00
2INHBB, GJA1
 7
GOBP_ENDOTHELIAL_CELL_DEVELOPMENT 2.16e-07 28.38 9.52 1.47e-04 1.61e-03
6CDH5, ENG, CLDN5, STC1, ROBO4, COL15A1
 66
GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER 8.29e-06 37.38 9.19 2.95e-03 6.20e-02
4ESAM, CDH5, GJA1, CLDN5
 33
GOBP_DORSAL_AORTA_MORPHOGENESIS 4.28e-04 86.37 8.33 6.68e-02 1.00e+00
2DLL4, ENG
 8
GOBP_PERICYTE_CELL_DIFFERENTIATION 4.28e-04 86.37 8.33 6.68e-02 1.00e+00
2CD34, GPR4
 8
GOBP_VASCULOGENESIS 5.85e-07 23.64 7.99 3.63e-04 4.38e-03
6KDR, EGFL7, CD34, ENG, ACKR3, TIE1
 78
GOBP_BLOOD_VESSEL_MORPHOGENESIS 9.55e-15 13.81 7.44 3.51e-11 7.14e-11
21AQP1, CLEC14A, CDH5, HSPG2, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, CLDN5, ROBO4, COL15A1, GPR4, CALCRL, ACKR3, SPARC, TIE1, ESM1, PTPRB
 677
GOBP_REGULATION_OF_GONADOTROPIN_SECRETION 5.49e-04 74.10 7.33 7.76e-02 1.00e+00
2INHBB, GJA1
 9
GOBP_TUBE_MORPHOGENESIS 1.41e-14 12.16 6.63 3.51e-11 1.05e-10
23AQP1, CLEC14A, CDH5, HSPG2, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, CLDN5, ROBO4, SPRY1, COL15A1, PODXL, GPR4, CALCRL, ACKR3, SPARC, TIE1, ESM1, PTPRB
 900
GOBP_DORSAL_AORTA_DEVELOPMENT 6.85e-04 64.86 6.55 8.99e-02 1.00e+00
2DLL4, ENG
 10
GOBP_VASCULATURE_DEVELOPMENT 1.54e-13 11.85 6.39 1.92e-10 1.15e-09
21AQP1, CLEC14A, CDH5, HSPG2, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, CLDN5, ROBO4, COL15A1, GPR4, CALCRL, ACKR3, SPARC, TIE1, ESM1, PTPRB
 786
GOBP_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER 3.76e-05 24.69 6.19 1.08e-02 2.81e-01
4CDH5, ENG, CLDN5, ROBO4
 48
GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS 1.38e-14 11.21 6.15 3.51e-11 1.03e-10
25AQP1, CLEC14A, CDH5, HSPG2, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, GJA1, CLDN5, ROBO4, SPRY1, HTRA1, COL15A1, PODXL, GPR4, CALCRL, ACKR3, SPARC, TIE1, ESM1, PTPRB
 1142
GOBP_TUBE_DEVELOPMENT 5.30e-14 10.89 5.96 9.91e-11 3.96e-10
24AQP1, CLEC14A, CDH5, HSPG2, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, GJA1, CLDN5, ROBO4, SPRY1, COL15A1, PODXL, GPR4, CALCRL, ACKR3, SPARC, TIE1, ESM1, PTPRB
 1085
GOBP_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING 2.01e-04 30.63 5.74 4.69e-02 1.00e+00
3KDR, CD34, GPR4
 29
GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT 1.44e-13 10.35 5.67 1.92e-10 1.08e-09
24AQP1, CLEC14A, CDH5, HSPG2, DLL4, KDR, FLT1, MMRN2, EGFL7, CD34, ENG, GJA1, CLDN5, ROBO4, SPRY1, COL15A1, GPR4, CALCRL, INSR, ACKR3, SPARC, TIE1, ESM1, PTPRB
 1140

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_UP 9.73e-07 12.40 4.96 4.74e-03 4.74e-03
8ESAM, CDH5, FAM167B, KDR, TM4SF1, SLC9A3R2, GPR4, TIE1
 200
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_UP 7.65e-04 7.72 2.36 8.77e-01 1.00e+00
5ESAM, TM4SF1, SPRY1, CYYR1, ACKR3
 185
GSE37605_C57BL6_VS_NOD_FOXP3_FUSION_GFP_TREG_DN 8.81e-04 7.47 2.29 8.77e-01 1.00e+00
5TM4SF1, SPRY1, CYYR1, GPR4, ACKR3
 191
GSE21360_PRIMARY_VS_SECONDARY_MEMORY_CD8_TCELL_UP 1.06e-03 7.16 2.19 8.77e-01 1.00e+00
5CD34, TM4SF1, ACKR3, SPARC, ERG
 199
GSE20715_0H_VS_48H_OZONE_TLR4_KO_LUNG_UP 1.08e-03 7.12 2.18 8.77e-01 1.00e+00
5DLL4, CLDN5, STC1, PALMD, IGFBP3
 200
GSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN 1.08e-03 7.12 2.18 8.77e-01 1.00e+00
5ESAM, CDH5, MECOM, GPR4, ERG
 200
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN 4.96e-03 6.32 1.63 1.00e+00 1.00e+00
4CLEC14A, TM4SF1, CYYR1, SPARC
 176
GSE3982_DC_VS_EFF_MEMORY_CD4_TCELL_DN 7.20e-03 5.66 1.47 1.00e+00 1.00e+00
4AQP1, CD34, TM4SF1, ACKR3
 196
GSE22886_TH1_VS_TH2_48H_ACT_UP 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4VWF, SPRY1, PREX2, ERG
 198
GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4AQP1, TM4SF1, ROBO4, SLC9A3R2
 199
GSE6681_DELETED_FOXP3_VS_WT_TREG_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4KDR, A2M, TM4SF1, ESM1
 199
GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4HSPG2, BCAM, INSR, ERG
 199
GSE17721_CTRL_VS_CPG_8H_BMDC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4ENG, TM4SF1, INSR, SPARC
 200
GSE17721_LPS_VS_PAM3CSK4_24H_BMDC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4CDH5, BCAM, SPARCL1, CALCRL
 200
GSE17721_POLYIC_VS_CPG_2H_BMDC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4SPRY1, SPARCL1, COL15A1, CALCRL
 200
GSE17721_LPS_VS_GARDIQUIMOD_2H_BMDC_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4CLDN5, SPRY1, HTRA1, CALCRL
 200
GSE24142_ADULT_VS_FETAL_EARLY_THYMIC_PROGENITOR_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4AQP1, ESAM, ABCG2, PODXL
 200
GSE2826_WT_VS_XID_BCELL_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4EMCN, VWF, ABCG2, TIE1
 200
GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4TM4SF1, ROBO4, CALCRL, SPARC
 200
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4AQP1, SPARCL1, HTRA1, IGFBP3
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MECOM 36 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
NR5A2 43 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PREX2 45 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ERG 47 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FZD4 52 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SOX7 55 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
BCL6B 58 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
WWTR1 59 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-activator that binds to TEADs (PMID: 19324877) and TBX5 (PMID: 16332960)
LMO2 68 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Protein binds to bHLH TFs, which then bind to DNA (PMID: 9707419). Both transfac motifs are suspect - the bHLH motif likely resulted from an indirect interaction.
ID1 72 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
PLXND1 85 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade.
ELK3 87 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FOXF1 96 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
NOTCH1 103 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None A transmembrane protein that inhibits MEF2C activation (PMID: 10082551). NOTCH1 does not bind DNA in the structure, and is not required for DNA binding, since RBPJ is bound without it in (PDB:4J2X).
ID3 112 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
EPAS1 125 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
RAPGEF3 153 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None No DBD and no evidence its a TF - included only because it has an x in Vaquerizas 2009
TAL1 164 Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain No motif yielded from PBMs or HT-SELEX. Binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA).
HOXB7 169 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HOXB8 171 Yes Known motif Monomer or homomultimer High-throughput in vitro None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T19_TTGCCGTCACGGCCAT.1 Endothelial_cells:HUVEC:IFNg 0.15 2015.86
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.38, Endothelial_cells:lymphatic:TNFa_48h: 0.37, Endothelial_cells:lymphatic: 0.36, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.34, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:HUVEC: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34, Endothelial_cells:HUVEC:H5N1-infected: 0.34, Endothelial_cells:lymphatic:KSHV: 0.33
T19_ATTTCTGTCGCATGAT.1 Endothelial_cells:HUVEC:IFNg 0.13 1692.81
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:HUVEC:PR8-infected: 0.31, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.31, Endothelial_cells:blood_vessel: 0.31, Endothelial_cells:HUVEC: 0.31, Endothelial_cells:HUVEC:B._anthracis_LT: 0.3, Endothelial_cells:HUVEC:H5N1-infected: 0.3, Endothelial_cells:HUVEC:FPV-infected: 0.3
T19_GACCTGGAGAGGGATA.1 HSC_CD34+ 0.06 1586.40
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.34, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:lymphatic: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.32, DC:monocyte-derived:AEC-conditioned: 0.32, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.32, DC:monocyte-derived:anti-DC-SIGN_2h: 0.32, Endothelial_cells:blood_vessel: 0.32, Endothelial_cells:lymphatic:KSHV: 0.31, DC:monocyte-derived:mature: 0.31
T19_CTGCGGAAGCCAACAG.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 1582.50
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:blood_vessel: 0.3, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.3, Endothelial_cells:HUVEC: 0.3, Endothelial_cells:HUVEC:B._anthracis_LT: 0.29, Endothelial_cells:HUVEC:PR8-infected: 0.29, Endothelial_cells:lymphatic:KSHV: 0.29, Endothelial_cells:HUVEC:H5N1-infected: 0.29
T19_GATCGTACACATAACC.1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.11 1390.87
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:lymphatic:TNFa_48h: 0.31, Endothelial_cells:lymphatic: 0.3, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.3, Endothelial_cells:blood_vessel: 0.29, Endothelial_cells:lymphatic:KSHV: 0.29, Endothelial_cells:HUVEC:PR8-infected: 0.29, Endothelial_cells:HUVEC:B._anthracis_LT: 0.29, Endothelial_cells:HUVEC: 0.29, Endothelial_cells:HUVEC:H5N1-infected: 0.28
T19_GTGGGTCTCCGAACGC.1 DC:monocyte-derived:LPS 0.11 1240.79
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.36, DC:monocyte-derived:anti-DC-SIGN_2h: 0.35, Macrophage:monocyte-derived:IFNa: 0.35, DC:monocyte-derived:LPS: 0.35, Monocyte:anti-FcgRIIB: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Macrophage:monocyte-derived:S._aureus: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, DC:monocyte-derived:Poly(IC): 0.35, DC:monocyte-derived:Galectin-1: 0.35
T19_GAACCTAAGGTGATAT.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 1113.85
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:lymphatic: 0.35, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.33, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:PR8-infected: 0.33, Endothelial_cells:HUVEC:FPV-infected: 0.32, Endothelial_cells:HUVEC: 0.32, Endothelial_cells:HUVEC:H5N1-infected: 0.32
T19_CCTTTCTGTAGAAGGA.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 1071.49
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:blood_vessel: 0.38, Endothelial_cells:HUVEC:IFNg: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:lymphatic:KSHV: 0.37, Endothelial_cells:HUVEC: 0.37, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.37, Endothelial_cells:HUVEC:H5N1-infected: 0.36
T19_GTTACAGCAATCCAAC.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 891.02
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:lymphatic: 0.37, Endothelial_cells:lymphatic:KSHV: 0.36, Endothelial_cells:blood_vessel: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34, Endothelial_cells:HUVEC:IFNg: 0.34, Endothelial_cells:HUVEC:IL-1b: 0.34, Endothelial_cells:HUVEC:FPV-infected: 0.34, Endothelial_cells:HUVEC: 0.34
T19_GAAACTCGTCAACTGT.1 Endothelial_cells:blood_vessel 0.10 809.35
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:blood_vessel: 0.32, Endothelial_cells:HUVEC:IFNg: 0.31, Endothelial_cells:HUVEC:FPV-infected: 0.31, Endothelial_cells:lymphatic:KSHV: 0.31, Endothelial_cells:HUVEC:B._anthracis_LT: 0.31, Endothelial_cells:HUVEC:PR8-infected: 0.31, Endothelial_cells:HUVEC: 0.31, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.3
T10_GGATTACGTTCGGCAC.1 Endothelial_cells:lymphatic:TNFa_48h 0.16 791.95
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.39, Endothelial_cells:lymphatic: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:blood_vessel: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.36, Endothelial_cells:HUVEC: 0.36, Endothelial_cells:HUVEC:H5N1-infected: 0.35, Endothelial_cells:lymphatic:KSHV: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.35
T19_TGAAAGATCTAACTCT.1 Endothelial_cells:lymphatic:TNFa_48h 0.11 663.72
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.36, Endothelial_cells:lymphatic: 0.35, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:HUVEC:IFNg: 0.34, Endothelial_cells:lymphatic:KSHV: 0.34, Endothelial_cells:HUVEC:PR8-infected: 0.33, Endothelial_cells:HUVEC:FPV-infected: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.32
T19_CTACGTCGTCCATGAT.1 Endothelial_cells:HUVEC:IFNg 0.12 641.83
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.37, Endothelial_cells:HUVEC:IFNg: 0.36, Endothelial_cells:lymphatic: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.35, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.35, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34, Endothelial_cells:HUVEC:H5N1-infected: 0.34, Endothelial_cells:HUVEC: 0.34, Endothelial_cells:lymphatic:KSHV: 0.34
T10_TCACAAGGTGTGCCTG.1 Endothelial_cells:lymphatic:TNFa_48h 0.13 628.83
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:lymphatic:KSHV: 0.33, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:HUVEC: 0.33, Endothelial_cells:HUVEC:VEGF: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.32, Endothelial_cells:HUVEC:B._anthracis_LT: 0.32, Endothelial_cells:HUVEC:IL-1b: 0.32
T19_CGCTATCTCACTCCTG.1 Neurons:Schwann_cell 0.14 625.02
Raw ScoresiPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Tissue_stem_cells:BM_MSC: 0.36, Osteoblasts: 0.36, Fibroblasts:breast: 0.35, Tissue_stem_cells:BM_MSC:osteogenic: 0.35, Smooth_muscle_cells:bronchial: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Chondrocytes:MSC-derived: 0.35
T19_TAAGTGCGTAGCTGCC.1 Endothelial_cells:lymphatic:TNFa_48h 0.15 608.94
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.37, Endothelial_cells:lymphatic: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:blood_vessel: 0.35, Endothelial_cells:HUVEC:H5N1-infected: 0.35, Endothelial_cells:HUVEC:B._anthracis_LT: 0.35, Endothelial_cells:lymphatic:KSHV: 0.35, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.34, Endothelial_cells:HUVEC: 0.34
T19_TTCTTAGAGCAGACTG.1 Endothelial_cells:lymphatic:TNFa_48h 0.12 595.93
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:lymphatic: 0.38, Endothelial_cells:blood_vessel: 0.37, Endothelial_cells:lymphatic:KSHV: 0.37, Endothelial_cells:HUVEC:IFNg: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.36, Endothelial_cells:HUVEC: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC:FPV-infected: 0.35, Endothelial_cells:HUVEC:H5N1-infected: 0.35
T19_CGGAGTCTCAGCATGT.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 536.69
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.36, Endothelial_cells:lymphatic: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34, Endothelial_cells:HUVEC:PR8-infected: 0.34, Endothelial_cells:HUVEC:FPV-infected: 0.34, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.34, Endothelial_cells:HUVEC:H5N1-infected: 0.33, Endothelial_cells:lymphatic:KSHV: 0.33
T19_AGGGTGAAGATAGTCA.1 Endothelial_cells:lymphatic:TNFa_48h 0.12 513.45
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:lymphatic: 0.35, Endothelial_cells:HUVEC:PR8-infected: 0.33, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.33, Endothelial_cells:lymphatic:KSHV: 0.32, Endothelial_cells:HUVEC:FPV-infected: 0.32, Endothelial_cells:HUVEC: 0.32
T19_TCAGGATTCTGGAGCC.1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.07 498.58
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.29, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.28, Endothelial_cells:lymphatic:TNFa_48h: 0.27, Endothelial_cells:HUVEC:PR8-infected: 0.27, Endothelial_cells:HUVEC:H5N1-infected: 0.27, Endothelial_cells:HUVEC:B._anthracis_LT: 0.26, Endothelial_cells:lymphatic: 0.26, Endothelial_cells:blood_vessel: 0.26, Endothelial_cells:HUVEC:FPV-infected: 0.26, Endothelial_cells:HUVEC: 0.25
T19_TGACTTTAGGAGTTTA.1 Endothelial_cells:lymphatic:TNFa_48h 0.12 491.55
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:lymphatic:KSHV: 0.33, Endothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:HUVEC:PR8-infected: 0.32, Endothelial_cells:HUVEC:FPV-infected: 0.32, Endothelial_cells:HUVEC:B._anthracis_LT: 0.32, Endothelial_cells:HUVEC: 0.32, Endothelial_cells:HUVEC:H5N1-infected: 0.32
T230_AGGTTGTCACCTCTGT-1 Endothelial_cells:HUVEC:IFNg 0.20 476.60
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.44, Endothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:HUVEC: 0.39
T200_AGACAGGTCACACCGG-1 Endothelial_cells:blood_vessel 0.16 466.69
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:IFNg: 0.39, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38
T19_GATGAAACAATGTTGC.1 Endothelial_cells:lymphatic:TNFa_48h 0.09 466.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:lymphatic: 0.33, Endothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:blood_vessel: 0.32, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.31, Endothelial_cells:HUVEC: 0.31, Endothelial_cells:lymphatic:KSHV: 0.31, Endothelial_cells:HUVEC:IL-1b: 0.31, Endothelial_cells:HUVEC:PR8-infected: 0.31, Endothelial_cells:HUVEC:B._anthracis_LT: 0.3
T69_GTAACGTTCGTCCGTT.1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.11 452.31
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.34, Endothelial_cells:lymphatic:TNFa_48h: 0.34, Endothelial_cells:HUVEC:VEGF: 0.34, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC: 0.33, Endothelial_cells:HUVEC:PR8-infected: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.33, Endothelial_cells:HUVEC:FPV-infected: 0.33
T19_GAGGTGAAGGACCACA.1 Endothelial_cells:lymphatic:TNFa_48h 0.12 447.72
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:blood_vessel: 0.31, Endothelial_cells:HUVEC:PR8-infected: 0.31, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.31, Endothelial_cells:HUVEC:B._anthracis_LT: 0.3, Endothelial_cells:HUVEC:H5N1-infected: 0.3, Endothelial_cells:HUVEC:FPV-infected: 0.3, Endothelial_cells:lymphatic:KSHV: 0.3
T19_CTACGTCAGGCGACAT.1 Tissue_stem_cells:iliac_MSC 0.11 403.87
Raw ScoresTissue_stem_cells:iliac_MSC: 0.33, Osteoblasts: 0.33, Fibroblasts:breast: 0.33, iPS_cells:adipose_stem_cells: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, Smooth_muscle_cells:bronchial: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32, Chondrocytes:MSC-derived: 0.32, Smooth_muscle_cells:vascular: 0.32
T214_TCACTCGCAAATTAGG-1 Endothelial_cells:blood_vessel 0.15 393.13
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:IL-1b: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.39, Endothelial_cells:HUVEC: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39
T19_CGCGTTTTCCTCATTA.1 Endothelial_cells:lymphatic:TNFa_48h 0.09 384.24
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.34, Endothelial_cells:lymphatic: 0.33, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:lymphatic:KSHV: 0.33, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.32, Endothelial_cells:HUVEC:PR8-infected: 0.32, Endothelial_cells:HUVEC: 0.32, Endothelial_cells:HUVEC:B._anthracis_LT: 0.32, Endothelial_cells:HUVEC:IL-1b: 0.31
T19_CATCCACAGTAACCCT.1 Endothelial_cells:lymphatic:TNFa_48h 0.12 375.83
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:HUVEC:IFNg: 0.34, Endothelial_cells:lymphatic:KSHV: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:PR8-infected: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.33, Endothelial_cells:HUVEC: 0.33, Endothelial_cells:HUVEC:FPV-infected: 0.32
T19_GCATACAAGATGTTAG.1 Neurons:Schwann_cell 0.09 364.58
Raw ScoresiPS_cells:adipose_stem_cells: 0.32, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Neurons:Schwann_cell: 0.32, Smooth_muscle_cells:bronchial: 0.32, Fibroblasts:breast: 0.32, Endothelial_cells:HUVEC:IFNg: 0.32, Osteoblasts: 0.32, Tissue_stem_cells:iliac_MSC: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32, Endothelial_cells:lymphatic:TNFa_48h: 0.32
T19_ACTGAACAGACCTAGG.1 Smooth_muscle_cells:bronchial 0.11 353.25
Raw ScoresiPS_cells:adipose_stem_cells: 0.33, Fibroblasts:breast: 0.33, Smooth_muscle_cells:bronchial: 0.32, Tissue_stem_cells:iliac_MSC: 0.32, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Smooth_muscle_cells:vascular: 0.32, Endothelial_cells:HUVEC:IFNg: 0.32, Osteoblasts: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32, Fibroblasts:foreskin: 0.32
T200_GTGTCCTGTTAGCTAC-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 327.93
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:HUVEC:IFNg: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4
T19_AGAGTGGCATTTGCCC.1 Endothelial_cells:lymphatic:TNFa_48h 0.11 326.75
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.32, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:blood_vessel: 0.31, Endothelial_cells:lymphatic:KSHV: 0.3, Endothelial_cells:HUVEC:IFNg: 0.3, Endothelial_cells:HUVEC:PR8-infected: 0.29, Endothelial_cells:HUVEC:B._anthracis_LT: 0.29, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.29, Endothelial_cells:HUVEC:FPV-infected: 0.29, Endothelial_cells:HUVEC: 0.29
T19_ACCAGTAAGGGTCGAT.1 Endothelial_cells:HUVEC:IFNg 0.05 309.00
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.27, Endothelial_cells:blood_vessel: 0.26, NK_cell: 0.26, Endothelial_cells:lymphatic: 0.26, DC:monocyte-derived:AEC-conditioned: 0.26, Endothelial_cells:HUVEC:PR8-infected: 0.26, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.26, DC:monocyte-derived:Poly(IC): 0.26, Endothelial_cells:HUVEC:B._anthracis_LT: 0.26
T200_ATTACCTCACTACACA-1 Endothelial_cells:lymphatic:TNFa_48h 0.19 306.36
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:HUVEC:IFNg: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.41, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4
T19_AAGGTTCAGCTCCTCT.1 DC:monocyte-derived:mature 0.03 277.08
Raw ScoresiPS_cells:adipose_stem_cells: 0.3, Endothelial_cells:HUVEC:IFNg: 0.3, Smooth_muscle_cells:bronchial: 0.3, Tissue_stem_cells:iliac_MSC: 0.3, Tissue_stem_cells:BM_MSC:BMP2: 0.3, Smooth_muscle_cells:bronchial:vit_D: 0.3, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Fibroblasts:foreskin: 0.29, Fibroblasts:breast: 0.29, Osteoblasts: 0.29
T19_GTTACAGGTACACCGC.1 Tissue_stem_cells:BM_MSC:TGFb3 0.11 268.75
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.35, iPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Fibroblasts:breast: 0.34, Osteoblasts: 0.34, Tissue_stem_cells:iliac_MSC: 0.34, iPS_cells:CRL2097_foreskin: 0.33, Tissue_stem_cells:BM_MSC: 0.33, Chondrocytes:MSC-derived: 0.33, Smooth_muscle_cells:bronchial: 0.33
T19_GGACGTCCACGGATAG.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 257.73
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:lymphatic: 0.37, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:lymphatic:KSHV: 0.34, Endothelial_cells:HUVEC:PR8-infected: 0.34, Endothelial_cells:HUVEC:FPV-infected: 0.34, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.33
T69_GTAACTGGTCAACTGT.1 Neurons:adrenal_medulla_cell_line 0.08 257.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.31, Endothelial_cells:lymphatic:TNFa_48h: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, Endothelial_cells:HUVEC:VEGF: 0.31, Endothelial_cells:HUVEC:IL-1b: 0.31, Endothelial_cells:HUVEC:FPV-infected: 0.31, Endothelial_cells:HUVEC: 0.31, Endothelial_cells:HUVEC:H5N1-infected: 0.31, Endothelial_cells:HUVEC:PR8-infected: 0.3
T69_AGCCTAAAGGAATCGC.1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.13 241.85
Raw ScoresEndothelial_cells:HUVEC:H5N1-infected: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:HUVEC:PR8-infected: 0.35, Endothelial_cells:HUVEC:FPV-infected: 0.35, Endothelial_cells:HUVEC: 0.35, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.35, Endothelial_cells:lymphatic:TNFa_48h: 0.34, Endothelial_cells:HUVEC:VEGF: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34, Endothelial_cells:lymphatic: 0.34
T10_GATGAGGAGACGCACA.1 Pro-B_cell_CD34+ 0.02 234.38
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.23, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.23, Endothelial_cells:lymphatic: 0.23, Endothelial_cells:lymphatic:TNFa_48h: 0.23, Endothelial_cells:HUVEC:PR8-infected: 0.22, Endothelial_cells:HUVEC:FPV-infected: 0.22, Endothelial_cells:HUVEC: 0.22, Pro-B_cell_CD34+: 0.22, Endothelial_cells:blood_vessel: 0.22, Endothelial_cells:HUVEC:B._anthracis_LT: 0.22
T200_AGTTAGCGTGCAATGG-1 Endothelial_cells:lymphatic:TNFa_48h 0.19 228.38
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:IFNg: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.39
T214_AACCTGATCTTCGTAT-1 Endothelial_cells:lymphatic 0.15 220.83
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:lymphatic: 0.39, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:lymphatic:KSHV: 0.38, Endothelial_cells:HUVEC: 0.38, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC:IL-1b: 0.38, Neurons:Schwann_cell: 0.37, Endothelial_cells:HUVEC:H5N1-infected: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37
T230_ATCCGTCGTAACAGGC-1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.18 199.44
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.43, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.42, Endothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.41, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41
T19_TAAGAGAGTTTGCATG.1 Tissue_stem_cells:BM_MSC:BMP2 0.09 199.08
Raw ScoresiPS_cells:adipose_stem_cells: 0.34, Fibroblasts:breast: 0.33, Tissue_stem_cells:iliac_MSC: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.33, Fibroblasts:foreskin: 0.33, Smooth_muscle_cells:bronchial: 0.33, Neurons:Schwann_cell: 0.33, Smooth_muscle_cells:bronchial:vit_D: 0.33, iPS_cells:CRL2097_foreskin: 0.32
T19_CTGCGGATCTGAGGGA.1 DC:monocyte-derived:AEC-conditioned 0.14 196.18
Raw ScoresMonocyte:leukotriene_D4: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37, Monocyte:CD16-: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, Monocyte:anti-FcgRIIB: 0.36, Monocyte: 0.36, Monocyte:CD16+: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.36, Monocyte:CD14+: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36
T200_TACGCTCGTTCTCAGA-1 Endothelial_cells:lymphatic:TNFa_48h 0.16 194.37
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:lymphatic: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC:H5N1-infected: 0.36, Endothelial_cells:lymphatic:KSHV: 0.36, Endothelial_cells:blood_vessel: 0.36, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.35, Endothelial_cells:HUVEC:FPV-infected: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35
T200_CATGCAATCAATCAGC-1 Endothelial_cells:lymphatic:TNFa_48h 0.13 190.27
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC:IFNg: 0.39
T19_CCACGGAGTTTACTCT.1 Monocyte:CD14+ 0.12 187.49
Raw ScoresMonocyte:CD16-: 0.39, Monocyte:CD14+: 0.38, Monocyte:CD16+: 0.38, DC:monocyte-derived:AEC-conditioned: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, Monocyte:leukotriene_D4: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg: 0.37, Monocyte: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37, Monocyte:anti-FcgRIIB: 0.37


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.57e-08
Mean rank of genes in gene set: 2003.8
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GJA1 0.0047114 18 GTEx DepMap Descartes 1.73 95.14
TM4SF1 0.0043025 22 GTEx DepMap Descartes 4.83 374.45
SPRY1 0.0040182 26 GTEx DepMap Descartes 4.08 346.34
MECOM 0.0036083 36 GTEx DepMap Descartes 0.63 22.26
IGFBP3 0.0034010 48 GTEx DepMap Descartes 4.22 311.68
DUSP6 0.0016526 157 GTEx DepMap Descartes 2.36 115.66
THBD 0.0014052 200 GTEx DepMap Descartes 0.84 45.79
ADAMTS1 0.0013153 213 GTEx DepMap Descartes 1.01 35.18
CLIC4 0.0008928 337 GTEx DepMap Descartes 1.42 70.22
IVNS1ABP 0.0007965 378 GTEx DepMap Descartes 1.41 71.15
RHOB 0.0007723 393 GTEx DepMap Descartes 4.80 400.43
HES1 0.0007658 399 GTEx DepMap Descartes 2.24 341.59
JAG1 0.0005533 545 GTEx DepMap Descartes 1.10 36.09
MCF2L 0.0003736 813 GTEx DepMap Descartes 0.34 9.41
LFNG 0.0001360 1949 GTEx DepMap Descartes 0.14 11.83
MARCKSL1 0.0000654 3158 GTEx DepMap Descartes 8.54 899.89
SHROOM2 0.0000427 3857 GTEx DepMap Descartes 0.07 1.79
FBLN2 -0.0000063 6323 GTEx DepMap Descartes 0.19 6.89
CDK1 -0.0000686 10601 GTEx DepMap Descartes 0.32 21.26
FAM102A -0.0000686 10603 GTEx DepMap Descartes 0.09 2.84


Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.95e-04
Mean rank of genes in gene set: 51.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
KDR 0.0050336 12 GTEx DepMap Descartes 2.01 63.87
FLT1 0.0049599 13 GTEx DepMap Descartes 2.91 74.63
EGFL7 0.0048722 15 GTEx DepMap Descartes 6.10 606.76
PRCP 0.0015923 166 GTEx DepMap Descartes 1.63 52.37


Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.40e-03
Mean rank of genes in gene set: 22.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PLVAP 0.0056084 5 GTEx DepMap Descartes 8.02 662.01
KDR 0.0050336 12 GTEx DepMap Descartes 2.01 63.87
PTPRB 0.0033957 50 GTEx DepMap Descartes 1.14 17.94




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9932.85
Median rank of genes in gene set: 11288
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GRB10 0.0016520 158 GTEx DepMap Descartes 0.84 30.35
RPS6KA2 0.0007238 421 GTEx DepMap Descartes 0.80 24.50
HEY1 0.0006401 472 GTEx DepMap Descartes 0.38 20.68
ABLIM1 0.0004415 691 GTEx DepMap Descartes 0.58 16.92
TSPAN7 0.0004016 753 GTEx DepMap Descartes 0.88 85.23
TSPAN13 0.0003170 950 GTEx DepMap Descartes 0.73 78.70
SYNPO2 0.0003109 968 GTEx DepMap Descartes 0.71 8.66
NCOA7 0.0002941 1020 GTEx DepMap Descartes 1.48 NA
SETD7 0.0002804 1067 GTEx DepMap Descartes 0.32 8.90
THSD7A 0.0002708 1102 GTEx DepMap Descartes 0.59 10.12
GNB1 0.0002620 1138 GTEx DepMap Descartes 1.74 94.57
MYRIP 0.0002213 1315 GTEx DepMap Descartes 0.05 1.36
LYN 0.0001788 1563 GTEx DepMap Descartes 0.53 18.24
AP1S2 0.0001651 1660 GTEx DepMap Descartes 1.21 68.94
RUNDC3B 0.0001573 1723 GTEx DepMap Descartes 0.23 11.32
CD200 0.0001518 1771 GTEx DepMap Descartes 0.71 68.95
SLC35G2 0.0001367 1940 GTEx DepMap Descartes 0.18 NA
INO80C 0.0001356 1954 GTEx DepMap Descartes 0.32 22.00
TBC1D30 0.0001281 2036 GTEx DepMap Descartes 0.14 2.71
CDC42EP3 0.0001220 2115 GTEx DepMap Descartes 0.78 29.63
ARHGEF7 0.0001217 2119 GTEx DepMap Descartes 0.46 14.41
PDK1 0.0000786 2853 GTEx DepMap Descartes 0.12 1.59
RNF144A 0.0000763 2907 GTEx DepMap Descartes 0.20 7.00
MYO5A 0.0000572 3391 GTEx DepMap Descartes 0.23 2.94
RALGDS 0.0000525 3531 GTEx DepMap Descartes 0.74 23.34
EXOC5 0.0000524 3535 GTEx DepMap Descartes 0.37 6.29
NET1 0.0000418 3889 GTEx DepMap Descartes 0.25 13.71
TMOD2 0.0000308 4323 GTEx DepMap Descartes 0.54 11.05
NRCAM 0.0000204 4784 GTEx DepMap Descartes 0.30 9.30
DPYSL2 0.0000186 4872 GTEx DepMap Descartes 1.68 61.08


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.23e-48
Mean rank of genes in gene set: 3781.87
Median rank of genes in gene set: 1806
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GJA1 0.0047114 18 GTEx DepMap Descartes 1.73 95.14
A2M 0.0046635 19 GTEx DepMap Descartes 10.26 448.67
TM4SF1 0.0043025 22 GTEx DepMap Descartes 4.83 374.45
SPRY1 0.0040182 26 GTEx DepMap Descartes 4.08 346.34
SPARCL1 0.0039332 28 GTEx DepMap Descartes 10.67 834.11
HTRA1 0.0038119 31 GTEx DepMap Descartes 3.36 282.83
SPARC 0.0034766 42 GTEx DepMap Descartes 27.05 1402.52
EMP1 0.0032214 57 GTEx DepMap Descartes 2.37 77.34
WWTR1 0.0031816 59 GTEx DepMap Descartes 1.63 65.89
COL4A1 0.0031168 62 GTEx DepMap Descartes 13.04 334.34
ID1 0.0028109 72 GTEx DepMap Descartes 5.56 1085.27
TGFBR2 0.0027133 82 GTEx DepMap Descartes 2.46 90.83
ELK3 0.0025460 87 GTEx DepMap Descartes 1.40 64.20
PDLIM1 0.0024784 89 GTEx DepMap Descartes 3.01 421.78
SEMA3F 0.0024481 90 GTEx DepMap Descartes 0.82 42.09
RAB13 0.0023035 99 GTEx DepMap Descartes 3.52 310.87
SPRY4 0.0021891 109 GTEx DepMap Descartes 0.89 28.49
COL4A2 0.0021639 111 GTEx DepMap Descartes 10.71 274.45
ID3 0.0021636 112 GTEx DepMap Descartes 9.98 2464.44
SERPINH1 0.0021092 116 GTEx DepMap Descartes 3.67 174.32
PTPN14 0.0020703 120 GTEx DepMap Descartes 0.45 6.97
RHOJ 0.0019316 133 GTEx DepMap Descartes 0.71 39.45
RGS3 0.0017979 146 GTEx DepMap Descartes 1.82 77.77
DUSP6 0.0016526 157 GTEx DepMap Descartes 2.36 115.66
PRCP 0.0015923 166 GTEx DepMap Descartes 1.63 52.37
CFI 0.0015166 173 GTEx DepMap Descartes 0.47 45.74
NFIA 0.0014866 179 GTEx DepMap Descartes 1.23 5.56
RHOC 0.0014694 184 GTEx DepMap Descartes 3.81 342.98
NID2 0.0014654 186 GTEx DepMap Descartes 0.54 23.02
LAMC1 0.0014575 189 GTEx DepMap Descartes 1.68 37.71


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.52e-01
Mean rank of genes in gene set: 6045.14
Median rank of genes in gene set: 5381
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SH3BP5 0.0007429 415 GTEx DepMap Descartes 1.32 83.39
SCARB1 0.0006151 486 GTEx DepMap Descartes 0.27 8.34
LDLR 0.0003549 856 GTEx DepMap Descartes 0.35 10.75
FDPS 0.0002423 1207 GTEx DepMap Descartes 1.65 149.03
BAIAP2L1 0.0002116 1374 GTEx DepMap Descartes 0.02 1.48
CYB5B 0.0001717 1614 GTEx DepMap Descartes 0.54 24.75
PDE10A 0.0001509 1784 GTEx DepMap Descartes 0.15 3.79
PAPSS2 0.0001349 1961 GTEx DepMap Descartes 0.17 5.53
CLU 0.0001025 2420 GTEx DepMap Descartes 1.86 183.90
NPC1 0.0000928 2592 GTEx DepMap Descartes 0.08 3.96
SH3PXD2B 0.0000727 2977 GTEx DepMap Descartes 0.12 2.75
IGF1R 0.0000718 3005 GTEx DepMap Descartes 0.30 3.94
DHCR7 0.0000633 3219 GTEx DepMap Descartes 0.12 7.24
POR 0.0000313 4303 GTEx DepMap Descartes 0.33 25.55
GRAMD1B 0.0000261 4524 GTEx DepMap Descartes 0.06 0.85
ERN1 0.0000157 5014 GTEx DepMap Descartes 0.16 3.96
FREM2 0.0000145 5071 GTEx DepMap Descartes 0.01 0.06
SCAP 0.0000104 5253 GTEx DepMap Descartes 0.27 10.13
FDX1 0.0000055 5509 GTEx DepMap Descartes 0.58 33.22
HMGCR 0.0000026 5667 GTEx DepMap Descartes 0.15 6.20
HMGCS1 -0.0000004 5840 GTEx DepMap Descartes 0.26 8.91
INHA -0.0000271 8097 GTEx DepMap Descartes 0.00 0.00
SGCZ -0.0000272 8104 GTEx DepMap Descartes 0.00 0.00
STAR -0.0000345 8655 GTEx DepMap Descartes 0.00 0.00
FDXR -0.0000348 8679 GTEx DepMap Descartes 0.14 12.78
MSMO1 -0.0000363 8778 GTEx DepMap Descartes 0.28 24.00
SLC16A9 -0.0000420 9170 GTEx DepMap Descartes 0.02 1.06
DHCR24 -0.0000549 9929 GTEx DepMap Descartes 0.07 1.57
FRMD5 -0.0000728 10745 GTEx DepMap Descartes 0.02 0.39
SLC1A2 -0.0000819 11055 GTEx DepMap Descartes 0.05 0.51


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11158.8
Median rank of genes in gene set: 11885
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SYNPO2 0.0003109 968 GTEx DepMap Descartes 0.71 8.66
GREM1 -0.0000325 8518 GTEx DepMap Descartes 0.06 0.69
EPHA6 -0.0000441 9300 GTEx DepMap Descartes 0.01 0.21
ANKFN1 -0.0000471 9486 GTEx DepMap Descartes 0.01 0.12
RPH3A -0.0000479 9545 GTEx DepMap Descartes 0.01 0.11
FAT3 -0.0000481 9559 GTEx DepMap Descartes 0.06 0.54
RYR2 -0.0000514 9757 GTEx DepMap Descartes 0.04 0.35
SLC44A5 -0.0000567 10033 GTEx DepMap Descartes 0.01 0.69
ALK -0.0000605 10236 GTEx DepMap Descartes 0.01 0.37
KCNB2 -0.0000651 10454 GTEx DepMap Descartes 0.02 0.62
PTCHD1 -0.0000687 10607 GTEx DepMap Descartes 0.05 0.70
HS3ST5 -0.0000695 10631 GTEx DepMap Descartes 0.01 0.22
EYA1 -0.0000781 10925 GTEx DepMap Descartes 0.04 1.99
EYA4 -0.0000868 11207 GTEx DepMap Descartes 0.02 0.12
PLXNA4 -0.0000898 11285 GTEx DepMap Descartes 0.03 0.16
CNKSR2 -0.0000923 11355 GTEx DepMap Descartes 0.04 0.57
SLC6A2 -0.0000923 11356 GTEx DepMap Descartes 0.02 0.52
RGMB -0.0000927 11367 GTEx DepMap Descartes 0.19 5.36
TMEM132C -0.0000931 11376 GTEx DepMap Descartes 0.00 0.00
TMEFF2 -0.0001036 11589 GTEx DepMap Descartes 0.06 1.86
REEP1 -0.0001233 11885 GTEx DepMap Descartes 0.09 3.46
RBFOX1 -0.0001294 11950 GTEx DepMap Descartes 0.05 2.31
NTRK1 -0.0001343 11995 GTEx DepMap Descartes 0.09 5.05
TUBB2A -0.0001461 12106 GTEx DepMap Descartes 1.61 131.33
IL7 -0.0001466 12113 GTEx DepMap Descartes 0.11 9.55
CCND1 -0.0001549 12187 GTEx DepMap Descartes 3.30 152.95
NPY -0.0001603 12212 GTEx DepMap Descartes 5.10 1116.83
MAB21L1 -0.0001605 12214 GTEx DepMap Descartes 0.42 22.19
MAB21L2 -0.0001628 12227 GTEx DepMap Descartes 0.29 12.18
ELAVL2 -0.0001665 12252 GTEx DepMap Descartes 0.31 11.52


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.62e-22
Mean rank of genes in gene set: 587.32
Median rank of genes in gene set: 100.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLVAP 0.0056084 5 GTEx DepMap Descartes 8.02 662.01
CDH5 0.0053446 7 GTEx DepMap Descartes 2.27 107.02
KDR 0.0050336 12 GTEx DepMap Descartes 2.01 63.87
MMRN2 0.0048994 14 GTEx DepMap Descartes 1.27 60.96
CLDN5 0.0046273 20 GTEx DepMap Descartes 5.81 473.58
ROBO4 0.0041193 25 GTEx DepMap Descartes 1.42 69.04
PODXL 0.0037162 33 GTEx DepMap Descartes 2.71 82.46
CALCRL 0.0035825 38 GTEx DepMap Descartes 1.59 60.20
NR5A2 0.0034462 43 GTEx DepMap Descartes 0.14 4.97
TIE1 0.0034401 44 GTEx DepMap Descartes 1.04 57.16
ESM1 0.0033963 49 GTEx DepMap Descartes 2.05 177.79
PTPRB 0.0033957 50 GTEx DepMap Descartes 1.14 17.94
SLCO2A1 0.0031678 60 GTEx DepMap Descartes 0.64 32.62
TMEM88 0.0031509 61 GTEx DepMap Descartes 1.17 294.75
ID1 0.0028109 72 GTEx DepMap Descartes 5.56 1085.27
TEK 0.0027414 77 GTEx DepMap Descartes 0.25 9.29
RAMP2 0.0026765 83 GTEx DepMap Descartes 7.54 1829.65
RASIP1 0.0026334 86 GTEx DepMap Descartes 0.84 58.18
SHE 0.0023023 100 GTEx DepMap Descartes 0.41 13.66
ARHGAP29 0.0022832 101 GTEx DepMap Descartes 3.23 77.47
FLT4 0.0021359 113 GTEx DepMap Descartes 0.57 18.57
KANK3 0.0020641 122 GTEx DepMap Descartes 0.72 66.16
NPR1 0.0020461 124 GTEx DepMap Descartes 0.30 14.09
BTNL9 0.0018818 140 GTEx DepMap Descartes 0.20 9.36
EFNB2 0.0017836 147 GTEx DepMap Descartes 1.79 56.16
NOTCH4 0.0017351 151 GTEx DepMap Descartes 1.23 34.08
SHANK3 0.0016619 156 GTEx DepMap Descartes 0.50 12.34
HYAL2 0.0013296 209 GTEx DepMap Descartes 2.94 148.98
GALNT15 0.0012545 231 GTEx DepMap Descartes 0.18 NA
CDH13 0.0011535 257 GTEx DepMap Descartes 0.68 13.56


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8805.5
Median rank of genes in gene set: 10705
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IGFBP3 0.0034010 48 GTEx DepMap Descartes 4.22 311.68
MGP 0.0005241 584 GTEx DepMap Descartes 15.24 2513.37
COL27A1 0.0004029 748 GTEx DepMap Descartes 0.13 2.36
LOX 0.0003692 821 GTEx DepMap Descartes 0.55 22.25
COL12A1 0.0001794 1557 GTEx DepMap Descartes 0.49 5.87
LRRC17 0.0001367 1938 GTEx DepMap Descartes 0.08 8.65
C7 0.0001277 2040 GTEx DepMap Descartes 0.31 12.79
ADAMTSL3 0.0000568 3400 GTEx DepMap Descartes 0.04 1.31
ELN 0.0000455 3767 GTEx DepMap Descartes 0.36 21.01
GLI2 0.0000146 5068 GTEx DepMap Descartes 0.01 0.06
POSTN -0.0000072 6396 GTEx DepMap Descartes 1.61 58.14
PRRX1 -0.0000094 6588 GTEx DepMap Descartes 0.43 20.34
RSPO3 -0.0000109 6715 GTEx DepMap Descartes 0.06 NA
PCDH18 -0.0000234 7786 GTEx DepMap Descartes 0.10 2.76
GAS2 -0.0000337 8604 GTEx DepMap Descartes 0.00 0.00
DKK2 -0.0000339 8621 GTEx DepMap Descartes 0.01 0.77
FREM1 -0.0000368 8816 GTEx DepMap Descartes 0.01 0.17
HHIP -0.0000411 9115 GTEx DepMap Descartes 0.05 0.45
PRICKLE1 -0.0000481 9565 GTEx DepMap Descartes 0.10 3.71
PAMR1 -0.0000617 10291 GTEx DepMap Descartes 0.17 11.17
ADAMTS2 -0.0000675 10557 GTEx DepMap Descartes 0.16 3.39
CCDC80 -0.0000686 10599 GTEx DepMap Descartes 0.88 10.28
SFRP2 -0.0000750 10811 GTEx DepMap Descartes 0.00 0.00
ITGA11 -0.0000843 11126 GTEx DepMap Descartes 0.02 0.25
CLDN11 -0.0000858 11170 GTEx DepMap Descartes 0.02 0.63
PDGFRA -0.0000910 11319 GTEx DepMap Descartes 0.16 4.51
SCARA5 -0.0000936 11386 GTEx DepMap Descartes 0.01 0.24
ABCA6 -0.0001019 11556 GTEx DepMap Descartes 0.07 1.81
ABCC9 -0.0001149 11771 GTEx DepMap Descartes 0.16 5.63
LAMC3 -0.0001299 11956 GTEx DepMap Descartes 0.02 0.32


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9264
Median rank of genes in gene set: 9839
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ROBO1 0.0003471 878 GTEx DepMap Descartes 0.53 10.42
LAMA3 0.0001593 1703 GTEx DepMap Descartes 0.04 1.29
CNTN3 0.0000130 5142 GTEx DepMap Descartes 0.01 0.10
FAM155A 0.0000081 5372 GTEx DepMap Descartes 0.16 2.22
SORCS3 -0.0000156 7139 GTEx DepMap Descartes 0.01 0.17
SLC24A2 -0.0000172 7254 GTEx DepMap Descartes 0.01 0.24
CDH18 -0.0000199 7483 GTEx DepMap Descartes 0.01 0.24
EML6 -0.0000199 7486 GTEx DepMap Descartes 0.02 0.19
TBX20 -0.0000211 7579 GTEx DepMap Descartes 0.00 0.00
ST18 -0.0000230 7736 GTEx DepMap Descartes 0.01 0.10
CCSER1 -0.0000265 8033 GTEx DepMap Descartes 0.02 NA
GRM7 -0.0000308 8397 GTEx DepMap Descartes 0.00 0.00
DGKK -0.0000314 8438 GTEx DepMap Descartes 0.01 0.35
AGBL4 -0.0000373 8838 GTEx DepMap Descartes 0.01 0.20
SLC35F3 -0.0000376 8862 GTEx DepMap Descartes 0.00 0.00
GALNTL6 -0.0000409 9098 GTEx DepMap Descartes 0.01 0.14
CDH12 -0.0000466 9464 GTEx DepMap Descartes 0.01 0.12
PACRG -0.0000509 9722 GTEx DepMap Descartes 0.03 5.38
PCSK2 -0.0000526 9822 GTEx DepMap Descartes 0.02 0.47
TIAM1 -0.0000533 9856 GTEx DepMap Descartes 0.11 2.50
GRID2 -0.0000610 10261 GTEx DepMap Descartes 0.02 0.30
TENM1 -0.0000614 10275 GTEx DepMap Descartes 0.01 NA
SPOCK3 -0.0000624 10325 GTEx DepMap Descartes 0.01 0.87
NTNG1 -0.0000657 10478 GTEx DepMap Descartes 0.07 1.43
HTATSF1 -0.0000748 10806 GTEx DepMap Descartes 0.48 28.24
MGAT4C -0.0000751 10813 GTEx DepMap Descartes 0.05 0.29
FGF14 -0.0000753 10823 GTEx DepMap Descartes 0.01 0.33
KSR2 -0.0000763 10861 GTEx DepMap Descartes 0.03 0.30
UNC80 -0.0000837 11112 GTEx DepMap Descartes 0.05 0.44
SLC18A1 -0.0000856 11166 GTEx DepMap Descartes 0.02 0.36


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.62e-01
Mean rank of genes in gene set: 6036.86
Median rank of genes in gene set: 6550
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SELENBP1 0.0005463 556 GTEx DepMap Descartes 0.24 24.97
RAPGEF2 0.0002954 1014 GTEx DepMap Descartes 0.43 11.90
GYPC 0.0002257 1287 GTEx DepMap Descartes 2.25 242.03
MARCH3 0.0002232 1303 GTEx DepMap Descartes 0.21 NA
SLC25A37 0.0001609 1690 GTEx DepMap Descartes 0.54 26.39
TRAK2 0.0001475 1820 GTEx DepMap Descartes 0.25 8.79
MICAL2 0.0001100 2303 GTEx DepMap Descartes 0.21 5.87
CPOX 0.0000586 3356 GTEx DepMap Descartes 0.09 5.45
ABCB10 0.0000553 3450 GTEx DepMap Descartes 0.08 3.83
RGS6 0.0000530 3514 GTEx DepMap Descartes 0.01 0.45
DENND4A 0.0000351 4146 GTEx DepMap Descartes 0.19 4.34
CAT 0.0000164 4974 GTEx DepMap Descartes 0.40 37.48
XPO7 0.0000044 5565 GTEx DepMap Descartes 0.14 5.68
RHD -0.0000073 6406 GTEx DepMap Descartes 0.00 0.00
TMCC2 -0.0000090 6550 GTEx DepMap Descartes 0.05 2.03
SLC25A21 -0.0000106 6690 GTEx DepMap Descartes 0.00 0.00
FECH -0.0000130 6910 GTEx DepMap Descartes 0.07 1.83
ALAS2 -0.0000175 7291 GTEx DepMap Descartes 0.02 0.44
BLVRB -0.0000193 7445 GTEx DepMap Descartes 0.71 88.00
ANK1 -0.0000293 8258 GTEx DepMap Descartes 0.07 0.61
SLC4A1 -0.0000293 8259 GTEx DepMap Descartes 0.00 0.00
TFR2 -0.0000366 8797 GTEx DepMap Descartes 0.09 2.51
TSPAN5 -0.0000375 8850 GTEx DepMap Descartes 0.57 26.98
GCLC -0.0000409 9096 GTEx DepMap Descartes 0.08 3.80
SPTB -0.0000508 9714 GTEx DepMap Descartes 0.01 0.14
SPECC1 -0.0000690 10620 GTEx DepMap Descartes 0.15 3.34
SOX6 -0.0000820 11056 GTEx DepMap Descartes 0.03 0.56
EPB41 -0.0001324 11974 GTEx DepMap Descartes 0.13 2.79
SNCA -0.0001528 12175 GTEx DepMap Descartes 0.27 15.49
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 7448.11
Median rank of genes in gene set: 8273.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RGL1 0.0003536 861 GTEx DepMap Descartes 0.28 12.02
SLCO2B1 0.0003397 897 GTEx DepMap Descartes 0.30 11.00
CD74 0.0002785 1076 GTEx DepMap Descartes 18.22 1308.59
HRH1 0.0002522 1178 GTEx DepMap Descartes 0.13 5.83
WWP1 0.0002459 1197 GTEx DepMap Descartes 0.36 13.41
IFNGR1 0.0002181 1339 GTEx DepMap Descartes 0.69 55.28
CST3 0.0002050 1407 GTEx DepMap Descartes 11.62 714.43
SFMBT2 0.0001326 1983 GTEx DepMap Descartes 0.08 2.23
PTPRE 0.0001124 2264 GTEx DepMap Descartes 0.72 22.97
SLC9A9 0.0000746 2945 GTEx DepMap Descartes 0.15 8.69
CTSB 0.0000629 3235 GTEx DepMap Descartes 2.40 125.88
ITPR2 0.0000422 3872 GTEx DepMap Descartes 0.28 4.54
MERTK 0.0000182 4884 GTEx DepMap Descartes 0.08 2.93
SPP1 0.0000125 5163 GTEx DepMap Descartes 1.21 201.62
CTSC -0.0000123 6843 GTEx DepMap Descartes 1.47 47.14
CTSD -0.0000131 6920 GTEx DepMap Descartes 1.88 171.23
ATP8B4 -0.0000211 7587 GTEx DepMap Descartes 0.03 0.95
CPVL -0.0000257 7976 GTEx DepMap Descartes 0.26 25.57
LGMN -0.0000269 8076 GTEx DepMap Descartes 1.15 85.12
RBPJ -0.0000320 8471 GTEx DepMap Descartes 0.75 23.32
ABCA1 -0.0000329 8542 GTEx DepMap Descartes 0.20 4.21
MS4A4A -0.0000491 9619 GTEx DepMap Descartes 0.34 32.68
CD14 -0.0000631 10362 GTEx DepMap Descartes 0.99 105.95
AXL -0.0000671 10533 GTEx DepMap Descartes 0.45 15.58
CSF1R -0.0000682 10586 GTEx DepMap Descartes 0.26 14.28
FMN1 -0.0000699 10640 GTEx DepMap Descartes 0.04 0.35
SLC1A3 -0.0001084 11673 GTEx DepMap Descartes 0.06 2.31
FGD2 -0.0001095 11692 GTEx DepMap Descartes 0.04 1.49
CD163 -0.0001271 11927 GTEx DepMap Descartes 0.13 4.94
CYBB -0.0001318 11969 GTEx DepMap Descartes 0.16 8.13


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 7990.64
Median rank of genes in gene set: 10256
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LAMA4 0.0016165 162 GTEx DepMap Descartes 2.95 78.85
LAMC1 0.0014575 189 GTEx DepMap Descartes 1.68 37.71
EDNRB 0.0012600 230 GTEx DepMap Descartes 0.84 36.36
VIM 0.0012285 238 GTEx DepMap Descartes 41.39 2682.43
COL18A1 0.0010475 285 GTEx DepMap Descartes 3.44 97.05
ADAMTS5 0.0010456 286 GTEx DepMap Descartes 0.41 7.48
LAMB1 0.0009850 301 GTEx DepMap Descartes 1.46 48.20
KCTD12 0.0005648 529 GTEx DepMap Descartes 0.77 26.49
STARD13 0.0002844 1048 GTEx DepMap Descartes 0.25 7.51
OLFML2A 0.0001863 1509 GTEx DepMap Descartes 0.70 18.17
EGFLAM 0.0001362 1943 GTEx DepMap Descartes 0.24 7.39
PLCE1 0.0000299 4368 GTEx DepMap Descartes 0.16 2.04
HMGA2 -0.0000008 5860 GTEx DepMap Descartes 0.01 0.05
MDGA2 -0.0000079 6455 GTEx DepMap Descartes 0.00 0.00
GRIK3 -0.0000118 6799 GTEx DepMap Descartes 0.04 0.85
COL25A1 -0.0000190 7416 GTEx DepMap Descartes 0.02 0.57
TRPM3 -0.0000276 8131 GTEx DepMap Descartes 0.01 0.09
ERBB4 -0.0000296 8282 GTEx DepMap Descartes 0.00 0.00
LRRTM4 -0.0000345 8658 GTEx DepMap Descartes 0.03 2.71
IL1RAPL2 -0.0000359 8756 GTEx DepMap Descartes 0.00 0.00
IL1RAPL1 -0.0000423 9184 GTEx DepMap Descartes 0.00 0.00
FIGN -0.0000575 10076 GTEx DepMap Descartes 0.10 1.15
PMP22 -0.0000648 10436 GTEx DepMap Descartes 1.45 151.88
VCAN -0.0000721 10721 GTEx DepMap Descartes 0.97 10.63
XKR4 -0.0000818 11047 GTEx DepMap Descartes 0.03 0.18
SORCS1 -0.0000865 11194 GTEx DepMap Descartes 0.05 1.69
SLC35F1 -0.0000915 11336 GTEx DepMap Descartes 0.07 1.23
NRXN3 -0.0000936 11388 GTEx DepMap Descartes 0.04 0.66
SOX5 -0.0000997 11508 GTEx DepMap Descartes 0.08 1.49
PTPRZ1 -0.0001180 11822 GTEx DepMap Descartes 0.05 0.47


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.80e-03
Mean rank of genes in gene set: 4705.42
Median rank of genes in gene set: 2354
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
STOM 0.0025355 88 GTEx DepMap Descartes 3.08 212.25
MCTP1 0.0013175 212 GTEx DepMap Descartes 0.38 15.23
MYH9 0.0011018 272 GTEx DepMap Descartes 2.82 76.84
SLC2A3 0.0009519 310 GTEx DepMap Descartes 1.72 75.24
FLI1 0.0008973 336 GTEx DepMap Descartes 0.38 16.13
ARHGAP6 0.0008925 338 GTEx DepMap Descartes 0.20 6.56
GSN 0.0007530 409 GTEx DepMap Descartes 6.74 218.80
THBS1 0.0006589 457 GTEx DepMap Descartes 2.04 45.61
FLNA 0.0006496 464 GTEx DepMap Descartes 2.50 52.24
MYLK 0.0005451 560 GTEx DepMap Descartes 1.20 20.28
TPM4 0.0005071 614 GTEx DepMap Descartes 5.28 189.92
TGFB1 0.0004971 628 GTEx DepMap Descartes 1.65 110.83
LIMS1 0.0004847 644 GTEx DepMap Descartes 2.59 102.38
CD9 0.0004329 699 GTEx DepMap Descartes 2.82 302.99
LTBP1 0.0003629 838 GTEx DepMap Descartes 0.42 9.91
TMSB4X 0.0002513 1182 GTEx DepMap Descartes 103.18 11965.91
VCL 0.0002099 1381 GTEx DepMap Descartes 0.85 18.35
RAP1B 0.0001888 1494 GTEx DepMap Descartes 1.70 23.54
ACTB 0.0001648 1662 GTEx DepMap Descartes 35.03 2869.62
ZYX 0.0001511 1781 GTEx DepMap Descartes 0.86 69.73
ACTN1 0.0001202 2138 GTEx DepMap Descartes 1.39 47.80
GP1BA 0.0001131 2249 GTEx DepMap Descartes 0.02 1.60
HIPK2 0.0001068 2354 GTEx DepMap Descartes 0.51 5.35
TLN1 0.0000862 2714 GTEx DepMap Descartes 1.45 27.36
ITGB3 0.0000194 4827 GTEx DepMap Descartes 0.01 0.19
MED12L 0.0000087 5343 GTEx DepMap Descartes 0.01 0.18
TRPC6 0.0000051 5530 GTEx DepMap Descartes 0.06 1.93
UBASH3B 0.0000034 5620 GTEx DepMap Descartes 0.04 1.08
P2RX1 -0.0000067 6356 GTEx DepMap Descartes 0.02 0.94
TUBB1 -0.0000089 6538 GTEx DepMap Descartes 0.01 1.02


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.91e-01
Mean rank of genes in gene set: 6963
Median rank of genes in gene set: 8150
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MSN 0.0011295 264 GTEx DepMap Descartes 3.06 145.94
ETS1 0.0007685 397 GTEx DepMap Descartes 1.63 60.18
B2M 0.0006107 489 GTEx DepMap Descartes 113.31 10383.87
PRKCH 0.0005885 514 GTEx DepMap Descartes 0.49 27.54
SP100 0.0005551 541 GTEx DepMap Descartes 1.54 62.71
ARHGDIB 0.0004509 679 GTEx DepMap Descartes 4.07 697.67
ABLIM1 0.0004415 691 GTEx DepMap Descartes 0.58 16.92
ITPKB 0.0003652 831 GTEx DepMap Descartes 0.26 8.72
MBNL1 0.0002704 1104 GTEx DepMap Descartes 1.00 30.70
PITPNC1 0.0002343 1240 GTEx DepMap Descartes 0.43 13.19
ARID5B 0.0002083 1389 GTEx DepMap Descartes 1.33 35.66
LEF1 0.0001576 1719 GTEx DepMap Descartes 0.39 20.03
FYN 0.0001500 1795 GTEx DepMap Descartes 1.18 61.68
TMSB10 0.0001100 2304 GTEx DepMap Descartes 70.51 27442.95
CCND3 0.0000687 3073 GTEx DepMap Descartes 0.48 38.82
WIPF1 0.0000290 4407 GTEx DepMap Descartes 0.46 21.59
FOXP1 0.0000144 5075 GTEx DepMap Descartes 1.02 21.71
MCTP2 -0.0000124 6850 GTEx DepMap Descartes 0.06 1.33
NCALD -0.0000131 6922 GTEx DepMap Descartes 0.19 11.25
SAMD3 -0.0000196 7470 GTEx DepMap Descartes 0.05 2.64
ARHGAP15 -0.0000207 7549 GTEx DepMap Descartes 0.36 28.89
SKAP1 -0.0000359 8751 GTEx DepMap Descartes 0.08 9.30
RCSD1 -0.0000366 8796 GTEx DepMap Descartes 0.27 12.85
CCL5 -0.0000428 9228 GTEx DepMap Descartes 0.29 45.30
SCML4 -0.0000679 10575 GTEx DepMap Descartes 0.01 0.44
BACH2 -0.0000741 10779 GTEx DepMap Descartes 0.08 1.00
ANKRD44 -0.0000823 11070 GTEx DepMap Descartes 0.10 2.74
PLEKHA2 -0.0000839 11117 GTEx DepMap Descartes 0.14 4.76
PDE3B -0.0000969 11453 GTEx DepMap Descartes 0.03 0.57
IKZF1 -0.0000977 11473 GTEx DepMap Descartes 0.04 1.42


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.10e-04
Mean rank of genes in gene set: 76.75
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MMRN2 0.0048994 14 GTEx DepMap Descartes 1.27 60.96
VWF 0.0045265 21 GTEx DepMap Descartes 8.28 195.57
JAM2 0.0019417 131 GTEx DepMap Descartes 0.87 43.71
RAMP3 0.0018773 141 GTEx DepMap Descartes 2.42 410.11


Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.39e-03
Mean rank of genes in gene set: 17.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PLVAP 0.0056084 5 GTEx DepMap Descartes 8.02 662.01
CLDN5 0.0046273 20 GTEx DepMap Descartes 5.81 473.58
SPARCL1 0.0039332 28 GTEx DepMap Descartes 10.67 834.11


B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.46e-02
Mean rank of genes in gene set: 687.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
YBX3 0.0009872 299 GTEx DepMap Descartes 2.73 NA
CD74 0.0002785 1076 GTEx DepMap Descartes 18.22 1308.59