Program: 12. Cell Cycle.

Program: 12. Cell Cycle.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 UBE2C 0.0182446 ubiquitin conjugating enzyme E2 C GTEx DepMap Descartes 26.85 473.51
2 CKS2 0.0167088 CDC28 protein kinase regulatory subunit 2 GTEx DepMap Descartes 13.39 340.97
3 CENPF 0.0162148 centromere protein F GTEx DepMap Descartes 18.30 61.44
4 CDK1 0.0152023 cyclin dependent kinase 1 GTEx DepMap Descartes 9.49 71.41
5 HMGB2 0.0151639 high mobility group box 2 GTEx DepMap Descartes 48.61 1588.50
6 CDC20 0.0143149 cell division cycle 20 GTEx DepMap Descartes 8.05 288.27
7 CENPE 0.0142521 centromere protein E GTEx DepMap Descartes 8.27 22.42
8 TPX2 0.0142331 TPX2 microtubule nucleation factor GTEx DepMap Descartes 8.23 28.23
9 CCNB1 0.0141412 cyclin B1 GTEx DepMap Descartes 8.58 193.34
10 H2AFX 0.0138880 NA GTEx DepMap Descartes 23.36 2577.17
11 BIRC5 0.0138758 baculoviral IAP repeat containing 5 GTEx DepMap Descartes 13.71 338.97
12 TOP2A 0.0138475 DNA topoisomerase II alpha GTEx DepMap Descartes 25.38 128.60
13 NUSAP1 0.0137677 nucleolar and spindle associated protein 1 GTEx DepMap Descartes 6.87 35.45
14 PRC1 0.0137612 protein regulator of cytokinesis 1 GTEx DepMap Descartes 7.82 57.16
15 CENPA 0.0133333 centromere protein A GTEx DepMap Descartes 12.06 228.50
16 MKI67 0.0133305 marker of proliferation Ki-67 GTEx DepMap Descartes 13.00 72.38
17 CCNA2 0.0129406 cyclin A2 GTEx DepMap Descartes 7.21 161.02
18 KIF23 0.0127404 kinesin family member 23 GTEx DepMap Descartes 3.37 16.72
19 PLK1 0.0127155 polo like kinase 1 GTEx DepMap Descartes 4.41 69.56
20 HMMR 0.0127081 hyaluronan mediated motility receptor GTEx DepMap Descartes 4.79 24.39
21 CKAP2L 0.0123016 cytoskeleton associated protein 2 like GTEx DepMap Descartes 4.38 23.85
22 AURKA 0.0122353 aurora kinase A GTEx DepMap Descartes 2.98 31.90
23 KIF11 0.0121501 kinesin family member 11 GTEx DepMap Descartes 4.31 14.21
24 CDCA8 0.0120593 cell division cycle associated 8 GTEx DepMap Descartes 8.51 63.88
25 SMC4 0.0120123 structural maintenance of chromosomes 4 GTEx DepMap Descartes 10.17 48.44
26 TACC3 0.0119629 transforming acidic coiled-coil containing protein 3 GTEx DepMap Descartes 5.13 38.48
27 KPNA2 0.0118593 karyopherin subunit alpha 2 GTEx DepMap Descartes 3.06 42.20
28 BUB1B 0.0118147 BUB1 mitotic checkpoint serine/threonine kinase B GTEx DepMap Descartes 3.40 11.56
29 ASPM 0.0117468 assembly factor for spindle microtubules GTEx DepMap Descartes 4.21 17.60
30 AURKB 0.0116996 aurora kinase B GTEx DepMap Descartes 3.84 88.61
31 KIF20A 0.0116224 kinesin family member 20A GTEx DepMap Descartes 3.69 69.34
32 SGOL2A 0.0114722 NA GTEx DepMap Descartes 3.13 NA
33 MIS18BP1 0.0111932 MIS18 binding protein 1 GTEx DepMap Descartes 3.66 14.66
34 TUBB4B 0.0111140 tubulin beta 4B class IVb GTEx DepMap Descartes 23.69 1585.68
35 UBE2S 0.0110995 ubiquitin conjugating enzyme E2 S GTEx DepMap Descartes 21.27 171.16
36 CDCA3 0.0110560 cell division cycle associated 3 GTEx DepMap Descartes 5.07 184.58
37 ARL6IP1 0.0110511 ADP ribosylation factor like GTPase 6 interacting protein 1 GTEx DepMap Descartes 24.32 376.73
38 KIF22 0.0108983 kinesin family member 22 GTEx DepMap Descartes 3.23 36.05
39 INCENP 0.0107483 inner centromere protein GTEx DepMap Descartes 4.99 30.23
40 CASC5 0.0105975 NA GTEx DepMap Descartes 3.86 NA
41 PTTG1 0.0105564 PTTG1 regulator of sister chromatid separation, securin GTEx DepMap Descartes 6.17 165.22
42 TUBA1C 0.0105203 tubulin alpha 1c GTEx DepMap Descartes 6.69 157.12
43 DLGAP5 0.0105125 DLG associated protein 5 GTEx DepMap Descartes 2.83 14.01
44 FAM64A 0.0104793 NA GTEx DepMap Descartes 2.88 NA
45 KIF2C 0.0104493 kinesin family member 2C GTEx DepMap Descartes 2.53 17.71
46 TUBA1B 0.0104459 tubulin alpha 1b GTEx DepMap Descartes 58.85 2696.16
47 KIF20B 0.0103793 kinesin family member 20B GTEx DepMap Descartes 3.38 9.63
48 CCNB2 0.0103295 cyclin B2 GTEx DepMap Descartes 5.23 59.15
49 SMC2 0.0102096 structural maintenance of chromosomes 2 GTEx DepMap Descartes 9.42 28.60
50 SPC25 0.0101009 SPC25 component of NDC80 kinetochore complex GTEx DepMap Descartes 4.52 61.60


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UMAP plots showing activity of gene expression program identified in GEP 12. Cell Cycle:

Interactive UMAP Plot
Interactive Boxplot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
FAN_EMBRYONIC_CTX_MICROGLIA_1 6.21e-80 772.89 355.99 1.39e-77 4.16e-77
41UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, SMC4, TACC3, KPNA2, BUB1B, ASPM, AURKB, KIF20A, TUBB4B, CDCA3, ARL6IP1, KIF22, PTTG1, TUBA1C, DLGAP5, KIF2C, KIF20B, CCNB2, SMC2, SPC25
 155
ZHONG_PFC_C1_OPC 1.67e-82 898.28 350.53 1.12e-79 1.12e-79
45UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, SMC4, TACC3, KPNA2, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, TUBB4B, UBE2S, CDCA3, ARL6IP1, KIF22, PTTG1, TUBA1C, DLGAP5, KIF2C, TUBA1B, KIF20B, CCNB2, SMC2, SPC25
 238
ZHONG_PFC_C2_UNKNOWN_NPC 3.63e-62 621.17 315.56 6.10e-60 2.44e-59
30UBE2C, CKS2, CENPF, CDC20, CENPE, TPX2, CCNB1, TOP2A, NUSAP1, MKI67, CCNA2, PLK1, CKAP2L, AURKA, CDCA8, TACC3, KPNA2, ASPM, AURKB, KIF20A, MIS18BP1, TUBB4B, CDCA3, ARL6IP1, KIF22, PTTG1, TUBA1C, DLGAP5, KIF2C, CCNB2
 76
FAN_EMBRYONIC_CTX_NSC_2 4.51e-80 759.42 309.82 1.39e-77 3.03e-77
44UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, SMC4, TACC3, KPNA2, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, TUBB4B, UBE2S, CDCA3, ARL6IP1, KIF22, PTTG1, TUBA1C, DLGAP5, KIF2C, KIF20B, CCNB2, SMC2, SPC25
 233
ZHONG_PFC_C8_ORG_PROLIFERATING 3.89e-46 416.83 209.08 2.37e-44 2.61e-43
23CKS2, CENPF, CDC20, CENPE, TPX2, CCNB1, BIRC5, NUSAP1, PRC1, CENPA, PLK1, AURKA, CDCA8, TACC3, BUB1B, ASPM, KIF20A, TUBB4B, CDCA3, ARL6IP1, PTTG1, TUBA1C, CCNB2
 62
ZHONG_PFC_MAJOR_TYPES_NPCS 4.85e-60 341.20 178.92 6.51e-58 3.26e-57
33UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, KIF23, CKAP2L, KIF11, SMC4, TACC3, KPNA2, ASPM, AURKB, MIS18BP1, TUBB4B, CDCA3, KIF22, PTTG1, DLGAP5, KIF2C, TUBA1B, CCNB2, SMC2, SPC25
 142
ZHONG_PFC_C3_UNKNOWN_INP 2.18e-30 354.58 159.81 9.13e-29 1.46e-27
15UBE2C, CENPF, CDK1, CENPE, TPX2, BIRC5, PRC1, CCNA2, KIF23, CKAP2L, CDCA8, KPNA2, DLGAP5, CCNB2, SPC25
 38
MANNO_MIDBRAIN_NEUROTYPES_HPROGFPM 1.42e-54 171.80 88.09 1.59e-52 9.56e-52
37UBE2C, CKS2, CENPF, CDK1, HMGB2, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, SMC4, TACC3, KPNA2, BUB1B, ASPM, AURKB, MIS18BP1, UBE2S, CDCA3, KIF22, PTTG1, DLGAP5, KIF2C, CCNB2, SMC2, SPC25
 356
TRAVAGLINI_LUNG_PROLIFERATING_NK_T_CELL 9.25e-38 154.27 81.62 4.77e-36 6.20e-35
23UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, TPX2, BIRC5, TOP2A, MKI67, CCNA2, HMMR, CDCA8, SMC4, TACC3, ASPM, AURKB, TUBB4B, CDCA3, KIF22, KIF2C, TUBA1B, SMC2
 129
MANNO_MIDBRAIN_NEUROTYPES_HPROGBP 1.08e-50 153.46 81.33 9.03e-49 7.22e-48
34UBE2C, CKS2, CENPF, CDK1, HMGB2, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, SMC4, TACC3, BUB1B, ASPM, AURKB, MIS18BP1, CDCA3, KIF22, PTTG1, DLGAP5, KIF2C, CCNB2, SPC25
 300
MANNO_MIDBRAIN_NEUROTYPES_HPROGFPL 1.44e-49 141.22 75.17 1.08e-47 9.69e-47
34UBE2C, CENPF, CDK1, HMGB2, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, SMC4, TACC3, BUB1B, ASPM, AURKB, MIS18BP1, CDCA3, KIF22, PTTG1, DLGAP5, KIF2C, CCNB2, SMC2, SPC25
 323
ZHONG_PFC_C1_MICROGLIA 2.29e-44 126.87 68.79 1.28e-42 1.54e-41
30UBE2C, CKS2, CENPF, CDK1, HMGB2, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, TACC3, KPNA2, ASPM, AURKB, CDCA3, KIF22, KIF2C, TUBA1B, KIF20B, CCNB2, SPC25
 257
GAO_LARGE_INTESTINE_24W_C2_MKI67POS_PROGENITOR 1.78e-30 125.26 64.48 7.97e-29 1.20e-27
19UBE2C, CENPF, CDK1, CDC20, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, TACC3, ASPM, AURKB, PTTG1, DLGAP5, KIF20B, CCNB2
 113
TRAVAGLINI_LUNG_PROLIFERATING_BASAL_CELL 1.38e-51 139.89 62.14 1.32e-49 9.27e-49
43UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, SMC4, TACC3, KPNA2, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, UBE2S, CDCA3, ARL6IP1, KIF22, PTTG1, TUBA1C, DLGAP5, KIF2C, TUBA1B, KIF20B, CCNB2, SMC2, SPC25
 891
GAO_LARGE_INTESTINE_ADULT_CH_MKI67HIGH_CELLS 7.51e-29 121.39 61.86 2.80e-27 5.04e-26
18CENPF, TPX2, BIRC5, TOP2A, CENPA, MKI67, CCNA2, KIF23, HMMR, CKAP2L, KIF11, CDCA8, TACC3, BUB1B, AURKB, KIF20A, CDCA3, KIF2C
 107
TRAVAGLINI_LUNG_PROLIFERATING_MACROPHAGE_CELL 4.92e-48 109.55 50.51 3.30e-46 3.30e-45
42UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, SMC4, TACC3, KPNA2, ASPM, AURKB, MIS18BP1, TUBB4B, UBE2S, CDCA3, ARL6IP1, KIF22, PTTG1, TUBA1C, DLGAP5, KIF2C, TUBA1B, KIF20B, CCNB2, SMC2, SPC25
 968
MANNO_MIDBRAIN_NEUROTYPES_HNPROG 9.99e-32 79.79 42.87 4.79e-30 6.70e-29
23UBE2C, CENPF, CDK1, HMGB2, TPX2, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, CCNA2, KIF23, PLK1, CKAP2L, KIF11, CDCA8, TACC3, BUB1B, ASPM, CDCA3, DLGAP5, KIF2C, CCNB2
 229
BUSSLINGER_ESOPHAGEAL_EARLY_SUPRABASAL_CELLS 8.10e-17 79.76 35.34 2.59e-15 5.43e-14
11CENPF, CDK1, HMGB2, CCNB1, TOP2A, PRC1, MKI67, SMC4, ASPM, PTTG1, TUBA1B
 79
BUSSLINGER_ESOPHAGEAL_PROLIFERATING_BASAL_CELLS 1.75e-15 80.39 34.14 5.35e-14 1.18e-12
10CENPF, HMGB2, TOP2A, NUSAP1, PRC1, MKI67, SMC4, ASPM, ARL6IP1, TUBA1B
 70
HAY_BONE_MARROW_PRO_B 7.48e-29 58.34 31.58 2.80e-27 5.02e-26
23UBE2C, CENPF, HMGB2, TPX2, BIRC5, TOP2A, NUSAP1, CENPA, MKI67, CKAP2L, KIF11, CDCA8, SMC4, TACC3, KPNA2, ASPM, AURKB, MIS18BP1, UBE2S, ARL6IP1, INCENP, TUBA1B, SPC25
 304

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_G2M_CHECKPOINT 4.78e-50 186.50 99.16 2.39e-48 2.39e-48
31UBE2C, CKS2, CENPF, CDK1, CDC20, CENPE, TPX2, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, AURKA, KIF11, SMC4, TACC3, KPNA2, AURKB, UBE2S, KIF22, INCENP, PTTG1, KIF2C, KIF20B, CCNB2, SMC2
 200
HALLMARK_E2F_TARGETS 3.92e-37 109.67 59.31 9.80e-36 1.96e-35
25CKS2, CDK1, HMGB2, CDC20, CENPE, BIRC5, TOP2A, MKI67, PLK1, HMMR, AURKA, CDCA8, SMC4, TACC3, KPNA2, BUB1B, AURKB, UBE2S, CDCA3, KIF22, PTTG1, DLGAP5, KIF2C, CCNB2, SPC25
 200
HALLMARK_MITOTIC_SPINDLE 1.38e-25 65.66 34.33 2.29e-24 6.88e-24
19CENPF, CDK1, CENPE, TPX2, BIRC5, TOP2A, NUSAP1, PRC1, KIF23, PLK1, AURKA, KIF11, SMC4, KIF22, INCENP, DLGAP5, KIF2C, KIF20B, CCNB2
 199
HALLMARK_GLYCOLYSIS 1.56e-04 10.98 3.37 1.95e-03 7.81e-03
5CDK1, CENPA, HMMR, AURKA, KIF20A
 200
HALLMARK_SPERMATOGENESIS 3.98e-04 12.79 3.30 3.98e-03 1.99e-02
4CDK1, AURKA, KIF2C, CCNB2
 135
HALLMARK_ESTROGEN_RESPONSE_LATE 1.46e-02 6.25 1.23 1.04e-01 7.29e-01
3CDC20, TOP2A, KIF20A
 200
HALLMARK_MYC_TARGETS_V1 1.46e-02 6.25 1.23 1.04e-01 7.29e-01
3CDC20, CCNA2, KPNA2
 200
HALLMARK_APOPTOSIS 6.42e-02 5.05 0.59 4.01e-01 1.00e+00
2HMGB2, TOP2A
 161
HALLMARK_MTORC1_SIGNALING 9.29e-02 4.06 0.47 5.16e-01 1.00e+00
2PLK1, AURKA
 200
HALLMARK_MYC_TARGETS_V2 1.39e-01 6.90 0.17 6.96e-01 1.00e+00
1PLK1
 58
HALLMARK_PEROXISOME 2.36e-01 3.82 0.09 9.90e-01 1.00e+00
1TOP2A
 104
HALLMARK_PI3K_AKT_MTOR_SIGNALING 2.38e-01 3.78 0.09 9.90e-01 1.00e+00
1CDK1
 105
HALLMARK_DNA_REPAIR 3.21e-01 2.64 0.07 1.00e+00 1.00e+00
1ARL6IP1
 150
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 87
HALLMARK_NOTCH_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 32

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_CELL_CYCLE 9.92e-10 31.36 12.44 1.85e-07 1.85e-07
8CDK1, CDC20, CCNB1, CCNA2, PLK1, BUB1B, PTTG1, CCNB2
 125
KEGG_OOCYTE_MEIOSIS 1.51e-08 29.59 10.98 1.40e-06 2.81e-06
7CDK1, CDC20, CCNB1, PLK1, AURKA, PTTG1, CCNB2
 113
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 2.59e-06 26.76 8.08 1.61e-04 4.82e-04
5CDK1, CCNB1, CCNA2, PLK1, CCNB2
 85
KEGG_GAP_JUNCTION 8.44e-05 19.48 4.98 3.93e-03 1.57e-02
4CDK1, TUBB4B, TUBA1C, TUBA1B
 90
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 4.06e-04 23.21 4.48 1.51e-02 7.56e-02
3TUBB4B, TUBA1C, TUBA1B
 56
KEGG_P53_SIGNALING_PATHWAY 7.18e-04 18.92 3.67 2.23e-02 1.34e-01
3CDK1, CCNB1, CCNB2
 68
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 5.04e-03 9.32 1.83 1.34e-01 9.38e-01
3UBE2C, CDC20, UBE2S
 135
KEGG_COLORECTAL_CANCER 1.48e-01 6.45 0.16 1.00e+00 1.00e+00
1BIRC5
 62
KEGG_ECM_RECEPTOR_INTERACTION 1.95e-01 4.74 0.12 1.00e+00 1.00e+00
1HMMR
 84
KEGG_PATHWAYS_IN_CANCER 5.66e-01 1.21 0.03 1.00e+00 1.00e+00
1BIRC5
 325
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_GLYCEROLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 49
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 25
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 77
KEGG_ETHER_LIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 33
KEGG_ARACHIDONIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 58

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr1p34 3.30e-02 4.52 0.90 1.00e+00 1.00e+00
3CDC20, CDCA8, KIF2C
 275
chr15q15 5.22e-02 5.70 0.66 1.00e+00 1.00e+00
2NUSAP1, BUB1B
 143
chr16p12 6.63e-02 4.96 0.58 1.00e+00 1.00e+00
2PLK1, ARL6IP1
 164
chr10q23 8.52e-02 4.27 0.50 1.00e+00 1.00e+00
2KIF11, KIF20B
 190
chr4q27 7.23e-02 14.05 0.34 1.00e+00 1.00e+00
1CCNA2
 29
chr5q34 9.36e-02 10.63 0.26 1.00e+00 1.00e+00
1HMMR
 38
chr20q13 2.69e-01 2.02 0.24 1.00e+00 1.00e+00
2UBE2C, AURKA
 400
chr12q13 2.76e-01 1.98 0.23 1.00e+00 1.00e+00
2TUBA1C, TUBA1B
 407
chr4q24 1.35e-01 7.15 0.17 1.00e+00 1.00e+00
1CENPE
 56
chr15q23 1.55e-01 6.15 0.15 1.00e+00 1.00e+00
1KIF23
 65
chr1q31 1.68e-01 5.62 0.14 1.00e+00 1.00e+00
1ASPM
 71
chr14q22 2.08e-01 4.42 0.11 1.00e+00 1.00e+00
1DLGAP5
 90
chr14q21 2.10e-01 4.37 0.11 1.00e+00 1.00e+00
1MIS18BP1
 91
chr1q41 2.12e-01 4.32 0.11 1.00e+00 1.00e+00
1CENPF
 92
chr17q24 2.16e-01 4.23 0.10 1.00e+00 1.00e+00
1KPNA2
 94
chr5q33 2.45e-01 3.64 0.09 1.00e+00 1.00e+00
1PTTG1
 109
chr10q21 2.59e-01 3.42 0.08 1.00e+00 1.00e+00
1CDK1
 116
chr15q22 2.74e-01 3.20 0.08 1.00e+00 1.00e+00
1CCNB2
 124
chr9q31 2.81e-01 3.10 0.08 1.00e+00 1.00e+00
1SMC2
 128
chr5q13 3.07e-01 2.79 0.07 1.00e+00 1.00e+00
1CCNB1
 142

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HSD17B8_TARGET_GENES 7.93e-41 72.30 38.20 8.98e-38 8.98e-38
35UBE2C, CENPF, CDK1, HMGB2, CDC20, CENPE, BIRC5, TOP2A, PRC1, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, CDCA8, SMC4, TACC3, KPNA2, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, CDCA3, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, KIF20B, CCNB2, SMC2, SPC25
 659
BARX2_TARGET_GENES 8.02e-16 12.32 6.78 4.55e-13 9.09e-13
26UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, TPX2, CCNB1, TOP2A, PRC1, CENPA, KIF23, CDCA8, KPNA2, ASPM, AURKB, MIS18BP1, TUBB4B, UBE2S, CDCA3, ARL6IP1, INCENP, DLGAP5, KIF2C, CCNB2, SPC25
 1723
CC2D1A_TARGET_GENES 3.07e-12 10.50 5.63 1.02e-09 3.48e-09
20CENPF, CDK1, HMGB2, CDC20, CENPE, PRC1, CCNA2, PLK1, AURKA, SMC4, BUB1B, ASPM, MIS18BP1, UBE2S, ARL6IP1, INCENP, PTTG1, TUBA1C, KIF20B, SPC25
 1245
BARX1_TARGET_GENES 3.99e-12 10.34 5.55 1.02e-09 4.52e-09
20UBE2C, CKS2, CENPF, HMGB2, CDC20, CENPE, TPX2, TOP2A, CENPA, PLK1, CDCA8, KPNA2, BUB1B, MIS18BP1, ARL6IP1, INCENP, TUBA1C, DLGAP5, TUBA1B, SPC25
 1264
E2F5_TARGET_GENES 4.50e-12 10.27 5.51 1.02e-09 5.10e-09
20CENPF, HMGB2, TPX2, BIRC5, TOP2A, CENPA, MKI67, CCNA2, PLK1, CDCA8, SMC4, BUB1B, AURKB, MIS18BP1, CDCA3, KIF22, DLGAP5, KIF20B, CCNB2, SPC25
 1273
ASH1L_TARGET_GENES 3.91e-11 9.02 4.84 7.39e-09 4.43e-08
20CKS2, CENPF, CDK1, CENPE, TPX2, CCNB1, TOP2A, CENPA, HMMR, CKAP2L, AURKA, CDCA8, KPNA2, ASPM, TUBB4B, CDCA3, INCENP, DLGAP5, CCNB2, SPC25
 1446
NFY_C 4.05e-05 10.77 3.72 4.42e-03 4.59e-02
6UBE2C, CKS2, KIF23, KIF20A, ARL6IP1, SPC25
 250
E2F2_TARGET_GENES 2.90e-08 6.79 3.54 4.69e-06 3.28e-05
17CENPF, CDK1, HMGB2, CENPE, TPX2, CCNB1, TOP2A, CENPA, CCNA2, KIF11, BUB1B, AURKB, KIF20A, ARL6IP1, INCENP, SMC2, SPC25
 1481
GATTGGY_NFY_Q6_01 5.22e-07 6.45 3.20 7.39e-05 5.91e-04
14UBE2C, CKS2, CENPF, CDK1, HMGB2, TPX2, TOP2A, KIF23, PLK1, AURKA, TACC3, KIF20A, TUBA1C, SPC25
 1177
PSMB5_TARGET_GENES 1.24e-04 8.73 3.02 1.08e-02 1.40e-01
6CKS2, TUBB4B, UBE2S, ARL6IP1, TUBA1C, TUBA1B
 307
AEBP2_TARGET_GENES 5.53e-06 5.97 2.83 6.96e-04 6.26e-03
12UBE2C, CENPF, CDK1, CENPE, TPX2, CCNB1, TOP2A, CENPA, TUBB4B, UBE2S, CDCA3, SPC25
 1033
RRCCGTTA_UNKNOWN 1.51e-03 14.47 2.83 8.56e-02 1.00e+00
3AURKA, UBE2S, TUBA1B
 88
NFY_01 5.25e-04 8.37 2.57 3.62e-02 5.94e-01
5CKS2, CDK1, KIF23, PLK1, TACC3
 261
NFY_Q6 5.43e-04 8.30 2.55 3.62e-02 6.15e-01
5CKS2, CENPF, CDK1, HMGB2, TOP2A
 263
ALPHACP1_01 5.43e-04 8.30 2.55 3.62e-02 6.15e-01
5UBE2C, CKS2, ASPM, CDCA3, DLGAP5
 263
PRKDC_TARGET_GENES 4.68e-05 5.57 2.48 4.42e-03 5.30e-02
10UBE2C, TOP2A, PRC1, CENPA, TUBB4B, UBE2S, CDCA3, INCENP, DLGAP5, CCNB2
 875
CEBPZ_TARGET_GENES 4.32e-05 4.50 2.19 4.42e-03 4.90e-02
13UBE2C, TOP2A, CENPA, CCNA2, CKAP2L, AURKA, CDCA8, TUBB4B, CDCA3, KIF22, INCENP, DLGAP5, SPC25
 1520
CHAMP1_TARGET_GENES 1.96e-03 8.22 2.13 1.01e-01 1.00e+00
4CENPF, CENPE, CCNA2, MIS18BP1
 208
TCCCRNNRTGC_UNKNOWN 2.24e-03 7.91 2.05 1.11e-01 1.00e+00
4PLK1, KIF11, BUB1B, SPC25
 216
ZBTB49_TARGET_GENES 1.29e-02 98.09 1.96 4.29e-01 1.00e+00
1TUBA1B
 5

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_MEIOTIC_CHROMOSOME_CONDENSATION 3.24e-07 403.56 53.00 3.36e-05 2.42e-03
3SMC4, INCENP, SMC2
 6
GOBP_CELL_DIVISION 4.22e-46 97.51 50.32 3.16e-42 3.16e-42
37UBE2C, CKS2, CENPF, CDK1, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, CCNA2, KIF23, PLK1, AURKA, KIF11, CDCA8, SMC4, TACC3, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, UBE2S, CDCA3, INCENP, PTTG1, TUBA1C, KIF2C, TUBA1B, KIF20B, CCNB2, SMC2, SPC25
 600
GOBP_KINETOCHORE_ORGANIZATION 1.58e-11 163.13 50.00 3.19e-09 1.18e-07
6CENPF, CENPE, CENPA, SMC4, DLGAP5, SMC2
 22
GOBP_MITOTIC_NUCLEAR_DIVISION 1.80e-38 91.37 49.80 6.72e-35 1.34e-34
28UBE2C, CENPF, CDK1, CDC20, CENPE, TPX2, CCNB1, NUSAP1, PRC1, MKI67, KIF23, PLK1, AURKA, KIF11, CDCA8, SMC4, TACC3, BUB1B, AURKB, UBE2S, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, KIF20B, CCNB2, SMC2
 296
GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION 3.63e-29 89.12 46.80 3.02e-26 2.72e-25
20UBE2C, CENPF, CDC20, CENPE, CCNB1, NUSAP1, PRC1, KIF23, PLK1, CDCA8, SMC4, TACC3, BUB1B, AURKB, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, SMC2
 164
GOBP_MITOTIC_NUCLEAR_ENVELOPE_DISASSEMBLY 1.93e-08 207.66 44.32 2.44e-06 1.44e-04
4CDK1, CCNB1, PLK1, CCNB2
 12
GOBP_SPINDLE_MIDZONE_ASSEMBLY 1.93e-08 207.66 44.32 2.44e-06 1.44e-04
4PRC1, KIF23, AURKB, INCENP
 12
GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION 4.88e-20 88.89 41.69 2.03e-17 3.65e-16
13UBE2C, CENPF, CDC20, CENPE, CCNB1, MKI67, PLK1, TACC3, BUB1B, AURKB, PTTG1, DLGAP5, KIF2C
 89
GOBP_SISTER_CHROMATID_SEGREGATION 2.63e-29 78.35 41.57 2.46e-26 1.97e-25
21UBE2C, CENPF, CDC20, CENPE, CCNB1, TOP2A, NUSAP1, PRC1, KIF23, PLK1, CDCA8, SMC4, TACC3, BUB1B, AURKB, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, SMC2
 199
GOBP_POSITIVE_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY 2.78e-08 184.41 40.22 3.46e-06 2.08e-04
4UBE2C, CDC20, PLK1, UBE2S
 13
GOBP_REGULATION_OF_CHROMOSOME_SEPARATION 2.34e-17 90.42 39.80 8.33e-15 1.75e-13
11UBE2C, CENPF, CDC20, CENPE, CCNB1, PLK1, TACC3, BUB1B, AURKB, PTTG1, DLGAP5
 71
GOBP_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE 6.80e-16 88.98 37.75 2.21e-13 5.08e-12
10UBE2C, CENPF, CDC20, CENPE, CCNB1, PLK1, TACC3, BUB1B, AURKB, DLGAP5
 64
GOBP_ORGANELLE_FISSION 6.02e-36 63.41 34.58 9.00e-33 4.50e-32
30UBE2C, CKS2, CENPF, CDK1, CDC20, CENPE, TPX2, CCNB1, TOP2A, NUSAP1, PRC1, MKI67, KIF23, PLK1, AURKA, KIF11, CDCA8, SMC4, TACC3, BUB1B, AURKB, UBE2S, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, KIF20B, CCNB2, SMC2
 486
GOBP_MEMBRANE_DISASSEMBLY 5.28e-08 152.08 33.97 6.37e-06 3.95e-04
4CDK1, CCNB1, PLK1, CCNB2
 15
GOBP_CHROMOSOME_SEPARATION 9.51e-18 73.21 33.62 3.56e-15 7.12e-14
12UBE2C, CENPF, CDC20, CENPE, CCNB1, TOP2A, PLK1, TACC3, BUB1B, AURKB, PTTG1, DLGAP5
 95
GOBP_SPINDLE_ELONGATION 1.35e-06 203.48 32.05 1.26e-04 1.01e-02
3PRC1, KIF23, AURKB
 9
GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS 8.30e-21 64.45 31.90 3.65e-18 6.21e-17
15CDC20, CENPE, TPX2, CCNB1, NUSAP1, PRC1, CENPA, KIF23, PLK1, AURKA, KIF11, TACC3, AURKB, DLGAP5, SPC25
 143
GOBP_CHROMOSOME_SEGREGATION 1.47e-29 56.80 30.87 1.57e-26 1.10e-25
24UBE2C, CENPF, CDC20, CENPE, CCNB1, BIRC5, TOP2A, NUSAP1, PRC1, MKI67, KIF23, PLK1, CDCA8, SMC4, TACC3, BUB1B, AURKB, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, SMC2, SPC25
 337
GOBP_MITOTIC_SPINDLE_ORGANIZATION 2.25e-18 64.42 30.53 8.87e-16 1.68e-14
13CDC20, CENPE, TPX2, CCNB1, PRC1, KIF23, PLK1, AURKA, KIF11, TACC3, AURKB, DLGAP5, SPC25
 118
GOBP_NUCLEAR_CHROMOSOME_SEGREGATION 2.27e-26 55.37 29.57 1.70e-23 1.70e-22
21UBE2C, CENPF, CDC20, CENPE, CCNB1, TOP2A, NUSAP1, PRC1, KIF23, PLK1, CDCA8, SMC4, TACC3, BUB1B, AURKB, KIF22, INCENP, PTTG1, DLGAP5, KIF2C, SMC2
 273

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE15750_DAY6_VS_DAY10_TRAF6KO_EFF_CD8_TCELL_UP 4.78e-50 186.50 99.16 2.33e-46 2.33e-46
31UBE2C, CENPF, CDK1, HMGB2, CENPE, TPX2, BIRC5, TOP2A, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, TACC3, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, TUBB4B, CDCA3, KIF22, INCENP, TUBA1B, KIF20B, CCNB2, SMC2, SPC25
 200
GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_UP 1.36e-45 154.74 83.89 2.21e-42 6.62e-42
29CKS2, CDK1, CDC20, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, KIF23, AURKA, KIF11, CDCA8, TACC3, KPNA2, ASPM, AURKB, KIF20A, MIS18BP1, CDCA3, KIF22, INCENP, TUBA1C, DLGAP5, KIF2C, TUBA1B, CCNB2, SMC2
 200
GSE15750_DAY6_VS_DAY10_EFF_CD8_TCELL_UP 1.36e-45 154.74 83.89 2.21e-42 6.62e-42
29UBE2C, CKS2, CDK1, CDC20, CENPE, TPX2, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, KPNA2, BUB1B, ASPM, AURKB, KIF20A, KIF22, KIF2C, TUBA1B, CCNB2, SMC2, SPC25
 200
GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP 4.02e-42 141.07 76.05 4.90e-39 1.96e-38
27CENPF, CDK1, HMGB2, CENPE, TPX2, BIRC5, TOP2A, PRC1, MKI67, CCNA2, KIF23, PLK1, HMMR, AURKA, KIF11, CDCA8, TACC3, BUB1B, ASPM, AURKB, MIS18BP1, CDCA3, INCENP, DLGAP5, CCNB2, SMC2, SPC25
 187
GSE14415_INDUCED_VS_NATURAL_TREG_DN 2.22e-40 134.32 72.52 2.16e-37 1.08e-36
26CENPF, CDK1, TPX2, BIRC5, TOP2A, CENPA, MKI67, CCNA2, KIF23, PLK1, HMMR, CKAP2L, KIF11, CDCA8, TACC3, KPNA2, BUB1B, ASPM, MIS18BP1, CDCA3, KIF22, INCENP, DLGAP5, KIF2C, CCNB2, SMC2
 181
GSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_UP 3.41e-39 119.61 64.72 2.77e-36 1.66e-35
26UBE2C, CKS2, CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, CCNB1, NUSAP1, PRC1, CENPA, CCNA2, PLK1, HMMR, AURKA, KIF11, CDCA8, TACC3, ASPM, KIF20A, KIF22, PTTG1, DLGAP5, KIF2C, CCNB2
 200
GSE13547_2H_VS_12_H_ANTI_IGM_STIM_BCELL_UP 1.44e-36 117.62 63.12 8.77e-34 7.02e-33
24CENPF, CDK1, HMGB2, CDC20, CENPE, TPX2, BIRC5, TOP2A, PRC1, MKI67, CCNA2, HMMR, CKAP2L, KIF11, CDCA8, TACC3, BUB1B, ASPM, MIS18BP1, CDCA3, KIF22, INCENP, PTTG1, CCNB2
 175
GSE14415_NATURAL_TREG_VS_TCONV_DN 2.94e-36 113.78 61.12 1.59e-33 1.43e-32
24CENPF, CDK1, HMGB2, CENPE, TPX2, BIRC5, TOP2A, PRC1, CCNA2, KIF23, PLK1, HMMR, CKAP2L, AURKA, KIF11, CDCA8, TACC3, BUB1B, ASPM, MIS18BP1, CDCA3, DLGAP5, CCNB2, SMC2
 180
GSE30962_PRIMARY_VS_SECONDARY_ACUTE_LCMV_INF_CD8_TCELL_UP 3.92e-37 109.67 59.31 2.73e-34 1.91e-33
25CKS2, CENPF, HMGB2, CENPE, BIRC5, TOP2A, NUSAP1, CENPA, CCNA2, KIF23, CKAP2L, KPNA2, BUB1B, ASPM, AURKB, KIF20A, MIS18BP1, TUBB4B, CDCA3, KIF22, DLGAP5, KIF20B, CCNB2, SMC2, SPC25
 200
GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP 4.19e-34 102.81 55.18 1.70e-31 2.04e-30
23CENPF, CDK1, CENPE, TPX2, TOP2A, PRC1, CENPA, MKI67, CCNA2, PLK1, HMMR, KIF11, CDCA8, KPNA2, ASPM, AURKB, MIS18BP1, CDCA3, KIF22, INCENP, KIF2C, CCNB2, SPC25
 182
GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_YOUNG_DN 4.14e-35 101.09 54.30 1.83e-32 2.02e-31
24UBE2C, CKS2, CDC20, CENPE, CCNB1, BIRC5, TOP2A, NUSAP1, CENPA, MKI67, HMMR, AURKA, KIF11, CDCA8, BUB1B, ASPM, KIF20A, CDCA3, PTTG1, TUBA1C, DLGAP5, KIF2C, TUBA1B, CCNB2
 200
GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_OLD_DN 4.14e-35 101.09 54.30 1.83e-32 2.02e-31
24UBE2C, CENPF, CDC20, TPX2, CCNB1, TOP2A, NUSAP1, CENPA, MKI67, CCNA2, KIF23, HMMR, AURKA, KIF11, BUB1B, ASPM, AURKB, KIF20A, CDCA3, TUBA1C, DLGAP5, TUBA1B, CCNB2, SMC2
 200
GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_DN 2.19e-33 95.36 51.11 8.22e-31 1.07e-29
23UBE2C, CENPF, CDK1, CDC20, CENPE, TPX2, CCNB1, BIRC5, PRC1, CENPA, MKI67, PLK1, HMMR, AURKA, CDCA8, ASPM, AURKB, KIF20A, UBE2S, CDCA3, PTTG1, DLGAP5, CCNB2
 195
GOLDRATH_NAIVE_VS_EFF_CD8_TCELL_DN 4.01e-33 92.67 49.70 1.15e-30 1.96e-29
23CKS2, CDK1, BIRC5, TOP2A, NUSAP1, PRC1, CENPA, MKI67, CCNA2, AURKA, KIF11, CDCA8, TACC3, ASPM, AURKB, KIF20A, MIS18BP1, CDCA3, KIF22, INCENP, DLGAP5, KIF2C, CCNB2
 200
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_UP 4.01e-33 92.67 49.70 1.15e-30 1.96e-29
23UBE2C, CKS2, CENPF, CDC20, CENPE, TPX2, CCNB1, BIRC5, NUSAP1, PRC1, CENPA, CCNA2, AURKA, KIF11, CDCA8, AURKB, TUBB4B, UBE2S, KIF22, PTTG1, DLGAP5, KIF2C, CCNB2
 200
GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_DN 4.01e-33 92.67 49.70 1.15e-30 1.96e-29
23UBE2C, CKS2, CDC20, CENPE, TPX2, CCNB1, BIRC5, TOP2A, NUSAP1, CENPA, MKI67, KIF23, HMMR, KIF11, CDCA8, ASPM, AURKB, KIF20A, CDCA3, TUBA1C, KIF2C, TUBA1B, CCNB2
 200
GSE39556_CD8A_DC_VS_NK_CELL_MOUSE_3H_POST_POLYIC_INJ_UP 4.01e-33 92.67 49.70 1.15e-30 1.96e-29
23CKS2, CDK1, CDC20, CENPE, TPX2, CCNB1, TOP2A, CENPA, CCNA2, KIF23, HMMR, AURKA, KIF11, SMC4, KPNA2, BUB1B, TUBB4B, UBE2S, KIF22, DLGAP5, KIF2C, KIF20B, CCNB2
 200
GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_UP 3.20e-29 89.75 47.12 8.20e-27 1.56e-25
20CENPF, CENPE, TPX2, TOP2A, PRC1, MKI67, CCNA2, KIF23, PLK1, CKAP2L, KIF11, CDCA8, TACC3, BUB1B, ASPM, MIS18BP1, UBE2S, KIF22, INCENP, SMC2
 163
GSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY7_UP 2.85e-31 85.97 45.88 7.71e-29 1.39e-27
22UBE2C, CDK1, HMGB2, CDC20, TPX2, CCNB1, BIRC5, NUSAP1, MKI67, CCNA2, KIF23, HMMR, KIF11, CDCA8, BUB1B, AURKB, KIF20A, TUBB4B, PTTG1, DLGAP5, KIF2C, CCNB2
 198
GSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_9H_UP 1.99e-27 71.73 37.88 4.61e-25 9.68e-24
20CKS2, CENPF, HMGB2, CDC20, CENPE, PRC1, MKI67, HMMR, CKAP2L, AURKA, KIF11, CDCA8, KPNA2, BUB1B, ASPM, KIF20A, KIF2C, TUBA1B, CCNB2, SPC25
 199

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
HMGB2 5 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB½ are non-sequence-specific binding proteins (PMID: 11497996). HMGB2 is well-known to facilitate DNA-bending and interact with sequence-specific TFs and transcriptional co-factors.
TOP2A 12 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNA topoisomerase. Binds DNA in the crystal structure (PDB: 4FM9).
CENPA 15 Yes Likely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone like protein. Binds DNA in the crystal structure (PDB: 3AN2).
MIS18BP1 33 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains 1 SANT domain, and a SANTA domain
PTTG1 41 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None GO annotation has no evidence for DNA-binding activity (PMID:9811450), only transcriptional activation in reporter experiments
KIF15 60 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Has a bZIP like fragment that lacks the basic region required for DNA binding and a STE-domain that is classified as a potential DBD in CIS-BP. It is a kinesin operating in the microtubule system (PMID: 24419385)
NDC80 63 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
NUCKS1 77 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Contains a GRP core, which is similar to an AT-hook. But, the amino acids flanking the core are quite different from an AT-hook. Could non-specifically bind to DNA, but lacks compelling evidence.
HMGB1 80 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB½ are non-sequence-specific binding proteins (PMID: 11497996).
HIST1H1B 81 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Linker histone. To my knowledge there has been no demonstration of sequence specificity of linker histones, so I think this one should be called unlikely.
RAD21 103 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Motifs are suspicious; protein is a component of the cohesin complex and there is no evidence for direct binding to DNA.
MXD3 107 Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).
HIST1H1E 113 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA as heteromultimeric complex
DEPDC1B 127 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein does not have known DBDs and has been shown to function as an inhibitor of a RhoA-based signaling complex (PMID: 25458010)
FOXM1 134 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
H1FX 145 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone component
H1F0 146 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone. Likely a false-positive Pfam match based on the similarity of Forkhead domains to H1 domains
HIST1H1A 154 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Histone component
TERF1 161 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375).
EME1 171 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA in the crystal structure (PDB: 4P0P) in a heterodimeric complex with MUS81.


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
X72_GGTAATCGTATCGTTG Neuroepithelial_cell:ESC-derived 0.37 426.56
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.74, Embryonic_stem_cells: 0.72, Keratinocytes: 0.68, Fibroblasts:breast: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.68, Chondrocytes:MSC-derived: 0.66
X71_TCCCAGTCATTGGCAT iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.42 393.21
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.81, Embryonic_stem_cells: 0.78, Neuroepithelial_cell:ESC-derived: 0.75, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.73, Gametocytes:oocyte: 0.71, iPS_cells:fibroblast-derived:Retroviral_transf: 0.71, Astrocyte:Embryonic_stem_cell-derived: 0.69, Keratinocytes:IL26: 0.69, MSC: 0.68, Keratinocytes:KGF: 0.67
X72_AGCGTATTCCAAGCAT Neuroepithelial_cell:ESC-derived 0.37 381.13
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.74, Embryonic_stem_cells: 0.72, Keratinocytes: 0.68, Fibroblasts:breast: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.68, Chondrocytes:MSC-derived: 0.66
X72_AAGCATCGTCTAATCG Keratinocytes:KGF 0.48 369.86
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X72_GTCTTTAGTGGCACTC Neuroepithelial_cell:ESC-derived 0.32 362.78
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.71, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.67, Keratinocytes:IL26: 0.65, Keratinocytes: 0.65, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.64, Embryonic_stem_cells: 0.64, Chondrocytes:MSC-derived: 0.63, Keratinocytes:IL20: 0.63, Keratinocytes:IFNg: 0.62
X72_AGCCAGCTCATTGCCC Neuroepithelial_cell:ESC-derived 0.35 358.43
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_CGCCAGAGTGATGGCA Neurons:ES_cell-derived_neural_precursor 0.38 350.26
Raw ScoresNeurons:ES_cell-derived_neural_precursor: 0.75, Neuroepithelial_cell:ESC-derived: 0.75, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.75, Embryonic_stem_cells: 0.73, MSC: 0.72, Fibroblasts:breast: 0.7, Keratinocytes: 0.7, Keratinocytes:IL26: 0.7, iPS_cells:adipose_stem_cells: 0.69, Astrocyte:Embryonic_stem_cell-derived: 0.68
X71_TCTCTGGGTCCAATCA Chondrocytes:MSC-derived 0.33 349.48
Raw ScoresChondrocytes:MSC-derived: 0.63, iPS_cells:adipose_stem_cells: 0.61, Smooth_muscle_cells:bronchial: 0.58, Smooth_muscle_cells:bronchial:vit_D: 0.58, Fibroblasts:breast: 0.57, MSC: 0.56, Osteoblasts: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.53, Osteoblasts:BMP2: 0.52, Erythroblast: 0.51
X72_CGAAGGACATTGTACG Neuroepithelial_cell:ESC-derived 0.37 347.39
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.74, Embryonic_stem_cells: 0.72, Keratinocytes: 0.68, Fibroblasts:breast: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.68, Chondrocytes:MSC-derived: 0.66
X71_ATTTCACCAGAACCGA Erythroblast 0.23 346.29
Raw ScoresErythroblast: 0.67, Neuroepithelial_cell:ESC-derived: 0.66, Smooth_muscle_cells:bronchial: 0.65, Neurons:ES_cell-derived_neural_precursor: 0.64, Gametocytes:oocyte: 0.63, MSC: 0.63, Smooth_muscle_cells:bronchial:vit_D: 0.63, Chondrocytes:MSC-derived: 0.62, DC:monocyte-derived:immature: 0.61, Neutrophil:LPS: 0.6
X72_TTCACGCGTCCGAAAG Neuroepithelial_cell:ESC-derived 0.33 343.72
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X72_CATCCACTCACCGCTT Keratinocytes:KGF 0.48 341.08
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X72_GGTAACTTCTGCTTAT iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.38 338.97
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.75, Neuroepithelial_cell:ESC-derived: 0.75, Neurons:ES_cell-derived_neural_precursor: 0.75, Embryonic_stem_cells: 0.73, MSC: 0.72, Fibroblasts:breast: 0.7, Keratinocytes: 0.7, Keratinocytes:IL26: 0.7, iPS_cells:adipose_stem_cells: 0.7, Astrocyte:Embryonic_stem_cell-derived: 0.68
X71_TAGATCGCATCCTAAG Neurons:ES_cell-derived_neural_precursor 0.40 337.24
Raw ScoresNeurons:ES_cell-derived_neural_precursor: 0.68, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.68, Neuroepithelial_cell:ESC-derived: 0.65, Embryonic_stem_cells: 0.65, Keratinocytes:KGF: 0.64, iPS_cells:adipose_stem_cells: 0.64, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.64, Keratinocytes:IL26: 0.63, Fibroblasts:breast: 0.63, Keratinocytes: 0.63
X72_GGGTTTACAGCTAACT Neuroepithelial_cell:ESC-derived 0.40 327.77
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X72_AAGACAAGTCAGGTGA Chondrocytes:MSC-derived 0.32 323.28
Raw ScoresChondrocytes:MSC-derived: 0.72, MSC: 0.66, iPS_cells:adipose_stem_cells: 0.65, Osteoblasts: 0.63, Smooth_muscle_cells:bronchial: 0.62, Smooth_muscle_cells:bronchial:vit_D: 0.62, Fibroblasts:breast: 0.62, Neuroepithelial_cell:ESC-derived: 0.62, Neurons:ES_cell-derived_neural_precursor: 0.61, Osteoblasts:BMP2: 0.59
X71_TCTATCAAGCACTCGC Neuroepithelial_cell:ESC-derived 0.33 321.14
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X72_ATCGTCCCAAGCAGGT Neuroepithelial_cell:ESC-derived 0.33 319.11
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.69, Neurons:ES_cell-derived_neural_precursor: 0.66, MSC: 0.65, Keratinocytes:IL26: 0.64, Keratinocytes: 0.64, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.62, Astrocyte:Embryonic_stem_cell-derived: 0.62, Embryonic_stem_cells: 0.61, Keratinocytes:IFNg: 0.61, Keratinocytes:IL20: 0.61
X72_AGCGCCAAGCGCCTAC iPS_cells:CRL2097_foreskin 0.20 318.45
Raw ScoresiPS_cells:CRL2097_foreskin: 0.57, DC:monocyte-derived:Poly(IC): 0.54, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.53, Fibroblasts:foreskin: 0.53, iPS_cells:foreskin_fibrobasts: 0.53, Endothelial_cells:HUVEC:IL-1b: 0.52, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.52, iPS_cells:skin_fibroblast: 0.52, MSC: 0.51, Endothelial_cells:lymphatic:KSHV: 0.49
X72_ACTGTGAAGTGCTCGC Neurons:ES_cell-derived_neural_precursor 0.29 310.14
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.66, Gametocytes:oocyte: 0.64, Chondrocytes:MSC-derived: 0.63, iPS_cells:PDB_2lox-17: 0.61, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, Erythroblast: 0.59, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.57
X72_CCACACTTCTGACCCT Neurons:ES_cell-derived_neural_precursor 0.27 304.45
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.67, Neurons:ES_cell-derived_neural_precursor: 0.67, MSC: 0.65, Chondrocytes:MSC-derived: 0.62, Gametocytes:oocyte: 0.62, iPS_cells:PDB_2lox-17: 0.61, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.58, iPS_cells:PDB_1lox-17Puro-10: 0.58, Embryonic_stem_cells: 0.56, Erythroblast: 0.55
X72_ATCGGCGGTACTCGAT Neuroepithelial_cell:ESC-derived 0.35 303.76
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_ATTTCTGTCAGCCTCT Keratinocytes:KGF 0.48 301.62
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X72_TCTCACGTCTTTCCGG Neuroepithelial_cell:ESC-derived 0.38 300.86
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.75, MSC: 0.73, Embryonic_stem_cells: 0.73, Fibroblasts:breast: 0.69, Keratinocytes: 0.69, Keratinocytes:IL26: 0.69, iPS_cells:adipose_stem_cells: 0.69, Astrocyte:Embryonic_stem_cell-derived: 0.67
X72_TCAATTCGTCCAGAAG Neuroepithelial_cell:ESC-derived 0.38 299.66
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.73, Embryonic_stem_cells: 0.73, Fibroblasts:breast: 0.68, Keratinocytes: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.68, Keratinocytes:KGF: 0.67
X71_ATCCCTGTCCATTCAT iPS_cells:adipose_stem_cells 0.35 294.66
Raw ScoresiPS_cells:adipose_stem_cells: 0.79, Fibroblasts:breast: 0.79, MSC: 0.74, Neurons:ES_cell-derived_neural_precursor: 0.74, Chondrocytes:MSC-derived: 0.73, Neuroepithelial_cell:ESC-derived: 0.72, Tissue_stem_cells:BM_MSC:TGFb3: 0.69, Smooth_muscle_cells:vascular: 0.66, Smooth_muscle_cells:vascular:IL-17: 0.66, Embryonic_stem_cells: 0.66
X72_GGGCGTTCACGCCACA iPS_cells:adipose_stem_cells 0.35 294.40
Raw ScoresiPS_cells:adipose_stem_cells: 0.79, Fibroblasts:breast: 0.79, MSC: 0.74, Neurons:ES_cell-derived_neural_precursor: 0.74, Chondrocytes:MSC-derived: 0.73, Neuroepithelial_cell:ESC-derived: 0.72, Tissue_stem_cells:BM_MSC:TGFb3: 0.69, Smooth_muscle_cells:vascular: 0.66, Smooth_muscle_cells:vascular:IL-17: 0.66, Embryonic_stem_cells: 0.66
X72_CACTGGGAGATTGACA iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.40 294.14
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, Keratinocytes:KGF: 0.65, iPS_cells:adipose_stem_cells: 0.65, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.65, Fibroblasts:breast: 0.65, Keratinocytes: 0.65, Keratinocytes:IL19: 0.65, Keratinocytes:IL20: 0.65, Keratinocytes:IL22: 0.65
X72_AACGTCATCCAACTGA Neuroepithelial_cell:ESC-derived 0.40 293.05
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X72_GTCATCCTCGCCAACG iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.38 290.58
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.75, Neuroepithelial_cell:ESC-derived: 0.75, Neurons:ES_cell-derived_neural_precursor: 0.75, Embryonic_stem_cells: 0.74, MSC: 0.72, Keratinocytes: 0.7, Keratinocytes:IL26: 0.7, Fibroblasts:breast: 0.7, iPS_cells:adipose_stem_cells: 0.7, Astrocyte:Embryonic_stem_cell-derived: 0.68
X72_AAGTCGTCATCGGCCA Neurons:ES_cell-derived_neural_precursor 0.33 286.13
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.64, Chondrocytes:MSC-derived: 0.63, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.57, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.55
X72_GGTCTGGTCCCAAGTA Neurons:ES_cell-derived_neural_precursor 0.25 284.42
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.67, Neurons:ES_cell-derived_neural_precursor: 0.67, MSC: 0.66, Gametocytes:oocyte: 0.63, iPS_cells:PDB_2lox-17: 0.62, Chondrocytes:MSC-derived: 0.62, iPS_cells:PDB_1lox-17Puro-10: 0.59, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.58, Erythroblast: 0.56, iPS_cells:PDB_2lox-21: 0.56
X72_GACTCAAGTTTAGAGA Monocyte 0.00 279.85
Raw ScoresMonocyte: 0.42, T_cell:CD4+: 0.42, B_cell: 0.42, B_cell:CXCR4+_centroblast: 0.42, B_cell:CXCR4-_centrocyte: 0.42, B_cell:Germinal_center: 0.42, B_cell:Memory: 0.42, B_cell:Naive: 0.42, B_cell:Plasma_cell: 0.42, B_cell:immature: 0.42
X72_TGGATCAAGGATCATA Keratinocytes:KGF 0.48 279.65
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X72_TTCGGTCGTGTACATC Chondrocytes:MSC-derived 0.34 278.59
Raw ScoresChondrocytes:MSC-derived: 0.64, iPS_cells:adipose_stem_cells: 0.62, Smooth_muscle_cells:bronchial: 0.58, Fibroblasts:breast: 0.58, Smooth_muscle_cells:bronchial:vit_D: 0.58, MSC: 0.55, Osteoblasts: 0.54, Osteoblasts:BMP2: 0.52, Neurons:ES_cell-derived_neural_precursor: 0.52, Erythroblast: 0.5
X71_TAACTTCAGCATCCTA Neuroepithelial_cell:ESC-derived 0.28 278.48
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.59, Neurons:ES_cell-derived_neural_precursor: 0.56, DC:monocyte-derived:immature: 0.54, Chondrocytes:MSC-derived: 0.54, Gametocytes:oocyte: 0.53, Erythroblast: 0.53, MSC: 0.52, iPS_cells:PDB_2lox-17: 0.48, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.47, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.47
X72_TCTGTCGTCAACCTTT Neuroepithelial_cell:ESC-derived 0.40 277.93
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X72_CATCGGGGTCCGACGT Neurons:ES_cell-derived_neural_precursor 0.33 276.46
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.64, Chondrocytes:MSC-derived: 0.63, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.57, Embryonic_stem_cells: 0.57, iPS_cells:PDB_1lox-17Puro-10: 0.55
X71_GCAACCGAGGGAGGTG Chondrocytes:MSC-derived 0.31 276.39
Raw ScoresChondrocytes:MSC-derived: 0.72, MSC: 0.66, iPS_cells:adipose_stem_cells: 0.66, Osteoblasts: 0.65, Smooth_muscle_cells:bronchial: 0.64, Smooth_muscle_cells:bronchial:vit_D: 0.64, Fibroblasts:breast: 0.63, Neuroepithelial_cell:ESC-derived: 0.62, Neurons:ES_cell-derived_neural_precursor: 0.62, Osteoblasts:BMP2: 0.61
X71_TGTAACGGTTAACCTG Neuroepithelial_cell:ESC-derived 0.35 274.84
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_TATTGGGTCGTCACCT Fibroblasts:breast 0.46 273.42
Raw ScoresFibroblasts:breast: 0.59, iPS_cells:adipose_stem_cells: 0.57, Chondrocytes:MSC-derived: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Epithelial_cells:bronchial: 0.44, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Keratinocytes:IL20: 0.43, Keratinocytes:IL26: 0.43, Keratinocytes:IL22: 0.43
X72_CTCCAACAGGTTGCCC Neuroepithelial_cell:ESC-derived 0.40 268.87
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.54, Neurons:ES_cell-derived_neural_precursor: 0.54, Chondrocytes:MSC-derived: 0.5, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.48, MSC: 0.47, Neurons:adrenal_medulla_cell_line: 0.46, Embryonic_stem_cells: 0.45, iPS_cells:adipose_stem_cells: 0.44, Gametocytes:oocyte: 0.44, Astrocyte:Embryonic_stem_cell-derived: 0.43
X72_CAACAGTCACAATGCT Neuroepithelial_cell:ESC-derived 0.35 268.30
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X71_CGAGTGCTCCTCACGT Neuroepithelial_cell:ESC-derived 0.38 268.19
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.76, Neurons:ES_cell-derived_neural_precursor: 0.76, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.74, MSC: 0.73, Embryonic_stem_cells: 0.73, Fibroblasts:breast: 0.68, Keratinocytes: 0.68, Keratinocytes:IL26: 0.68, iPS_cells:adipose_stem_cells: 0.68, Keratinocytes:KGF: 0.67
X72_CTGAGCGCAGACCCGT iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.40 268.02
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, Keratinocytes:KGF: 0.65, iPS_cells:adipose_stem_cells: 0.65, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.65, Fibroblasts:breast: 0.65, Keratinocytes: 0.65, Keratinocytes:IL19: 0.65, Keratinocytes:IL20: 0.65, Keratinocytes:IL22: 0.65
X71_ATCATTCCACACAGAG Neuroepithelial_cell:ESC-derived 0.33 267.92
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.63, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.59, Embryonic_stem_cells: 0.58, Neurons:adrenal_medulla_cell_line: 0.55
X72_GAGAGGTTCCCTTCCC Neuroepithelial_cell:ESC-derived 0.35 265.71
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.58, Neurons:ES_cell-derived_neural_precursor: 0.58, Erythroblast: 0.57, Gametocytes:oocyte: 0.57, MSC: 0.57, Chondrocytes:MSC-derived: 0.54, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.54, Keratinocytes:KGF: 0.5, Neurons:adrenal_medulla_cell_line: 0.5, iPS_cells:adipose_stem_cells: 0.5
X72_TTCATGTTCAAATAGG Keratinocytes:KGF 0.48 264.89
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.42, Keratinocytes:KGF: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.42, Neurons:adrenal_medulla_cell_line: 0.42, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.42, iPS_cells:adipose_stem_cells: 0.42, Chondrocytes:MSC-derived: 0.42, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.41, Erythroblast: 0.4, Gametocytes:oocyte: 0.4
X72_TGTCAGACAAAGGCGT Neuroepithelial_cell:ESC-derived 0.33 262.89
Raw ScoresNeuroepithelial_cell:ESC-derived: 0.68, Neurons:ES_cell-derived_neural_precursor: 0.68, MSC: 0.65, Chondrocytes:MSC-derived: 0.64, Gametocytes:oocyte: 0.62, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.6, iPS_cells:PDB_2lox-17: 0.59, Erythroblast: 0.58, Embryonic_stem_cells: 0.57, Neurons:adrenal_medulla_cell_line: 0.55
X72_AGGGAGTAGATCGGTG iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff 0.41 260.98
Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.64, Astrocyte:Embryonic_stem_cell-derived: 0.62, Fibroblasts:breast: 0.62, Keratinocytes: 0.62, Keratinocytes:IL26: 0.62, Neuroepithelial_cell:ESC-derived: 0.61, Neurons:ES_cell-derived_neural_precursor: 0.61, Embryonic_stem_cells: 0.61, iPS_cells:adipose_stem_cells: 0.61, Keratinocytes:KGF: 0.59


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.69e-04
Mean rank of genes in gene set: 8.25
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
UBE2C 0.0182446 1 GTEx DepMap Descartes 26.85 473.51
CDK1 0.0152023 4 GTEx DepMap Descartes 9.49 71.41
TOP2A 0.0138475 12 GTEx DepMap Descartes 25.38 128.60
MKI67 0.0133305 16 GTEx DepMap Descartes 13.00 72.38


Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.23e-03
Mean rank of genes in gene set: 5726.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RTN1 0.0003576 2802 GTEx DepMap Descartes 3.88 2.46
ISL1 0.0003072 3137 GTEx DepMap Descartes 1.70 22.60
TH 0.0002305 3805 GTEx DepMap Descartes 0.44 1.87
MLLT11 0.0001825 4352 GTEx DepMap Descartes 1.61 14.27
ELAVL4 0.0001778 4430 GTEx DepMap Descartes 1.15 0.90
DBH 0.0001494 4822 GTEx DepMap Descartes 0.94 9.71
STMN2 0.0001451 4891 GTEx DepMap Descartes 4.88 10.33
BEX1 0.0001393 4980 GTEx DepMap Descartes 4.42 307.28
UCHL1 0.0001321 5114 GTEx DepMap Descartes 4.40 53.91
MAP1B 0.0000098 8036 GTEx DepMap Descartes 7.21 9.86
NRG1 -0.0000505 10182 GTEx DepMap Descartes 0.24 0.02
RGS5 -0.0001116 12167 GTEx DepMap Descartes 0.15 0.44


Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.69e-03
Mean rank of genes in gene set: 104
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MKI67 0.0133305 16 GTEx DepMap Descartes 13.00 72.38
EZH2 0.0038827 192 GTEx DepMap Descartes 7.15 15.18




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.72e-13
Mean rank of genes in gene set: 7555.64
Median rank of genes in gene set: 6210
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
UBE2C 0.0182446 1 GTEx DepMap Descartes 26.85 473.51
BIRC5 0.0138758 11 GTEx DepMap Descartes 13.71 338.97
NUSAP1 0.0137677 13 GTEx DepMap Descartes 6.87 35.45
PRC1 0.0137612 14 GTEx DepMap Descartes 7.82 57.16
TUBB4B 0.0111140 34 GTEx DepMap Descartes 23.69 1585.68
ARL6IP1 0.0110511 37 GTEx DepMap Descartes 24.32 376.73
KNSTRN 0.0091906 58 GTEx DepMap Descartes 3.45 13.64
KIF15 0.0089686 60 GTEx DepMap Descartes 3.26 6.53
PBK 0.0077547 78 GTEx DepMap Descartes 3.13 38.38
NUF2 0.0073051 88 GTEx DepMap Descartes 2.02 10.08
CDKN3 0.0062299 114 GTEx DepMap Descartes 0.87 14.02
FOXM1 0.0054263 134 GTEx DepMap Descartes 1.12 12.47
LSM3 0.0051137 143 GTEx DepMap Descartes 7.04 133.21
H1FX 0.0050693 145 GTEx DepMap Descartes 11.28 1528.96
HN1 0.0047905 155 GTEx DepMap Descartes 20.64 NA
CDCA5 0.0043959 165 GTEx DepMap Descartes 1.17 25.27
CDKN2C 0.0039234 190 GTEx DepMap Descartes 0.32 7.61
RANBP1 0.0037509 197 GTEx DepMap Descartes 21.85 290.26
UBE2T 0.0036587 203 GTEx DepMap Descartes 0.95 10.20
ZWILCH 0.0033578 220 GTEx DepMap Descartes 0.71 2.72
RFC4 0.0030919 244 GTEx DepMap Descartes 3.17 31.81
GMNN 0.0030779 248 GTEx DepMap Descartes 4.30 51.92
RRM2 0.0030747 249 GTEx DepMap Descartes 5.15 111.29
VRK1 0.0030281 255 GTEx DepMap Descartes 1.91 3.51
DNAJC9 0.0029111 266 GTEx DepMap Descartes 4.91 149.86
CSE1L 0.0027458 275 GTEx DepMap Descartes 2.50 7.52
FIGNL1 0.0024524 309 GTEx DepMap Descartes 1.33 7.36
LSM4 0.0024455 312 GTEx DepMap Descartes 10.86 238.59
HNRNPA0 0.0021327 362 GTEx DepMap Descartes 16.05 748.77
CENPU 0.0021096 364 GTEx DepMap Descartes 0.66 2.99


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13359.41
Median rank of genes in gene set: 15879
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TUBB6 0.0024515 310 GTEx DepMap Descartes 1.65 22.50
EMP1 0.0023445 327 GTEx DepMap Descartes 4.11 22.74
HIST1H2BK 0.0016396 503 GTEx DepMap Descartes 0.21 64.48
SEPT10 0.0014455 599 GTEx DepMap Descartes 1.33 2.13
HSP90B1 0.0014237 611 GTEx DepMap Descartes 24.51 220.96
PRDX4 0.0013236 676 GTEx DepMap Descartes 6.52 57.17
CLIC4 0.0013110 683 GTEx DepMap Descartes 2.41 5.05
PTBP1 0.0009186 1066 GTEx DepMap Descartes 7.84 93.69
ELAVL1 0.0009116 1076 GTEx DepMap Descartes 5.55 17.52
CBFB 0.0008955 1111 GTEx DepMap Descartes 1.78 4.73
DUSP6 0.0007674 1309 GTEx DepMap Descartes 1.20 35.45
ACTN1 0.0007455 1356 GTEx DepMap Descartes 2.44 3.37
PLSCR1 0.0006942 1488 GTEx DepMap Descartes 0.39 2.48
RBMS1 0.0006554 1580 GTEx DepMap Descartes 5.47 3.10
SUCLG2 0.0006096 1706 GTEx DepMap Descartes 2.73 1.18
MOB1A 0.0006060 1715 GTEx DepMap Descartes 1.50 9.93
HIST1H2AC 0.0005490 1901 GTEx DepMap Descartes 0.03 1.80
MYL12A 0.0005446 1921 GTEx DepMap Descartes 12.72 159.32
RAP1A 0.0005011 2081 GTEx DepMap Descartes 2.38 4.03
SLC38A2 0.0004924 2127 GTEx DepMap Descartes 3.43 36.80
POLR2L 0.0004794 2176 GTEx DepMap Descartes 1.84 63.77
FAM120A 0.0004708 2207 GTEx DepMap Descartes 2.23 2.90
SPRED1 0.0004667 2224 GTEx DepMap Descartes 1.86 4.06
ELK4 0.0004597 2260 GTEx DepMap Descartes 0.87 4.07
ETS1 0.0004512 2293 GTEx DepMap Descartes 0.63 0.75
MBD2 0.0004482 2308 GTEx DepMap Descartes 2.89 5.69
SNAI2 0.0004325 2383 GTEx DepMap Descartes 1.83 64.86
SPRY1 0.0004269 2413 GTEx DepMap Descartes 1.85 40.44
ANXA1 0.0004268 2414 GTEx DepMap Descartes 2.38 12.42
IQGAP2 0.0004066 2535 GTEx DepMap Descartes 0.68 0.43


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.89e-01
Mean rank of genes in gene set: 10355.12
Median rank of genes in gene set: 11002
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LDLR 0.0013689 650 GTEx DepMap Descartes 0.74 3.80
HSPD1 0.0009582 1012 GTEx DepMap Descartes 20.18 222.54
HSPE1 0.0007233 1409 GTEx DepMap Descartes 31.97 1138.16
HMGCS1 0.0007111 1436 GTEx DepMap Descartes 4.58 33.95
HMGCR 0.0006511 1595 GTEx DepMap Descartes 2.27 14.89
CYB5B 0.0005935 1752 GTEx DepMap Descartes 1.63 5.07
FDPS 0.0005828 1788 GTEx DepMap Descartes 3.94 56.72
MSMO1 0.0005229 2010 GTEx DepMap Descartes 1.95 17.66
IGF1R 0.0004033 2551 GTEx DepMap Descartes 3.47 1.49
DHCR24 0.0003510 2851 GTEx DepMap Descartes 1.57 6.63
MC2R 0.0002466 3654 GTEx DepMap Descartes 0.02 0.08
FDXR 0.0002188 3911 GTEx DepMap Descartes 0.43 6.78
JAKMIP2 0.0001693 4534 GTEx DepMap Descartes 0.16 0.15
SLC1A2 0.0001287 5172 GTEx DepMap Descartes 0.16 0.19
FRMD5 0.0000684 6342 GTEx DepMap Descartes 0.05 0.03
TM7SF2 0.0000526 6743 GTEx DepMap Descartes 0.25 5.22
STAR 0.0000445 6946 GTEx DepMap Descartes 0.04 0.56
DNER 0.0000219 7628 GTEx DepMap Descartes 0.28 0.13
DHCR7 0.0000217 7632 GTEx DepMap Descartes 0.87 4.53
SGCZ -0.0000028 8486 GTEx DepMap Descartes 0.02 0.00
CYP11A1 -0.0000282 9393 GTEx DepMap Descartes 0.03 0.15
POR -0.0001263 12611 GTEx DepMap Descartes 1.17 2.45
SH3BP5 -0.0001393 12993 GTEx DepMap Descartes 0.83 1.34
CYP11B1 -0.0001636 13644 GTEx DepMap Descartes 0.02 0.25
ERN1 -0.0002080 14677 GTEx DepMap Descartes 0.13 0.15
SLC16A9 -0.0002526 15445 GTEx DepMap Descartes 0.03 0.11
FDX1 -0.0002713 15737 GTEx DepMap Descartes 1.82 10.54
PAPSS2 -0.0002991 16135 GTEx DepMap Descartes 0.55 1.50
GRAMD1B -0.0002998 16139 GTEx DepMap Descartes 0.15 0.10
SCAP -0.0003153 16352 GTEx DepMap Descartes 0.77 1.76


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.96e-02
Mean rank of genes in gene set: 8280.02
Median rank of genes in gene set: 7946.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MAB21L1 0.0006945 1487 GTEx DepMap Descartes 0.32 22.72
TUBA1A 0.0005872 1774 GTEx DepMap Descartes 37.07 1373.60
BASP1 0.0005485 1904 GTEx DepMap Descartes 20.03 53.29
TUBB2B 0.0004732 2193 GTEx DepMap Descartes 11.20 413.41
ISL1 0.0003072 3137 GTEx DepMap Descartes 1.70 22.60
TUBB2A 0.0002998 3192 GTEx DepMap Descartes 3.90 141.53
EYA1 0.0002462 3657 GTEx DepMap Descartes 0.56 0.61
RBFOX1 0.0002266 3848 GTEx DepMap Descartes 0.34 0.03
STMN4 0.0001952 4170 GTEx DepMap Descartes 0.61 4.73
NTRK1 0.0001832 4342 GTEx DepMap Descartes 0.50 2.59
MLLT11 0.0001825 4352 GTEx DepMap Descartes 1.61 14.27
NPY 0.0001550 4737 GTEx DepMap Descartes 0.90 24.07
STMN2 0.0001451 4891 GTEx DepMap Descartes 4.88 10.33
RPH3A 0.0001332 5101 GTEx DepMap Descartes 0.02 0.05
GAL 0.0001243 5229 GTEx DepMap Descartes 0.33 5.57
MAB21L2 0.0001233 5256 GTEx DepMap Descartes 0.66 24.11
HS3ST5 0.0000815 6014 GTEx DepMap Descartes 0.05 0.02
REEP1 0.0000645 6440 GTEx DepMap Descartes 0.28 0.27
MARCH11 0.0000567 6640 GTEx DepMap Descartes 0.09 0.11
GAP43 0.0000526 6747 GTEx DepMap Descartes 3.99 5.10
FAT3 0.0000479 6854 GTEx DepMap Descartes 0.34 0.09
EPHA6 0.0000145 7857 GTEx DepMap Descartes 0.00 0.00
MAP1B 0.0000098 8036 GTEx DepMap Descartes 7.21 9.86
TMEFF2 0.0000091 8059 GTEx DepMap Descartes 0.31 0.14
KCNB2 0.0000054 8201 GTEx DepMap Descartes 0.12 0.04
TMEM132C 0.0000020 8326 GTEx DepMap Descartes 0.56 0.30
ELAVL2 -0.0000012 8430 GTEx DepMap Descartes 1.21 1.00
EYA4 -0.0000220 9191 GTEx DepMap Descartes 0.12 0.08
IL7 -0.0000395 9772 GTEx DepMap Descartes 0.00 0.01
ANKFN1 -0.0000396 9781 GTEx DepMap Descartes 0.00 0.00


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 11349.67
Median rank of genes in gene set: 12244
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APLNR 0.0003978 2578 GTEx DepMap Descartes 0.08 3.18
CYP26B1 0.0003759 2690 GTEx DepMap Descartes 0.23 1.99
PLVAP 0.0002468 3651 GTEx DepMap Descartes 0.23 1.87
ID1 0.0002017 4099 GTEx DepMap Descartes 6.41 788.24
NR5A2 0.0001571 4710 GTEx DepMap Descartes 0.01 0.01
ROBO4 0.0001329 5107 GTEx DepMap Descartes 0.03 0.33
KANK3 0.0000658 6411 GTEx DepMap Descartes 0.21 2.30
NOTCH4 0.0000162 7797 GTEx DepMap Descartes 0.07 0.49
KDR 0.0000151 7836 GTEx DepMap Descartes 0.19 0.53
ESM1 0.0000082 8080 GTEx DepMap Descartes 0.00 0.09
RASIP1 -0.0000151 8941 GTEx DepMap Descartes 0.12 1.26
NPR1 -0.0000391 9765 GTEx DepMap Descartes 0.05 0.45
EHD3 -0.0000463 10021 GTEx DepMap Descartes 0.27 1.38
CDH13 -0.0000549 10340 GTEx DepMap Descartes 1.12 0.12
CRHBP -0.0000571 10411 GTEx DepMap Descartes 0.00 0.02
FLT4 -0.0000642 10636 GTEx DepMap Descartes 0.03 0.08
CHRM3 -0.0000898 11509 GTEx DepMap Descartes 0.03 0.01
PTPRB -0.0000979 11756 GTEx DepMap Descartes 0.04 0.04
FCGR2B -0.0001057 12000 GTEx DepMap Descartes 0.00 0.01
TEK -0.0001091 12087 GTEx DepMap Descartes 0.09 0.10
SHANK3 -0.0001099 12112 GTEx DepMap Descartes 0.04 0.09
SHE -0.0001142 12244 GTEx DepMap Descartes 0.04 0.19
CEACAM1 -0.0001190 12384 GTEx DepMap Descartes 0.00 0.08
TIE1 -0.0001197 12413 GTEx DepMap Descartes 0.04 0.31
SOX18 -0.0001252 12565 GTEx DepMap Descartes 0.03 1.96
GALNT15 -0.0001354 12876 GTEx DepMap Descartes 0.00 0.00
BTNL9 -0.0001401 13014 GTEx DepMap Descartes 0.01 0.04
HYAL2 -0.0001451 13135 GTEx DepMap Descartes 1.96 47.31
TMEM88 -0.0001591 13526 GTEx DepMap Descartes 0.18 10.98
CALCRL -0.0001606 13567 GTEx DepMap Descartes 0.13 0.18


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15105.04
Median rank of genes in gene set: 17344
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FREM1 0.0004982 2099 GTEx DepMap Descartes 0.40 0.31
GLI2 0.0003223 3020 GTEx DepMap Descartes 0.51 0.28
PRRX1 0.0002117 3982 GTEx DepMap Descartes 2.13 5.83
PCDH18 0.0001864 4291 GTEx DepMap Descartes 1.62 17.34
EDNRA 0.0001397 4972 GTEx DepMap Descartes 0.48 1.18
C7 0.0000872 5897 GTEx DepMap Descartes 0.00 0.00
ADAMTSL3 -0.0000159 8973 GTEx DepMap Descartes 0.03 0.02
PDGFRA -0.0000828 11279 GTEx DepMap Descartes 1.47 5.79
LAMC3 -0.0000918 11572 GTEx DepMap Descartes 0.01 0.03
ABCA6 -0.0001119 12175 GTEx DepMap Descartes 0.02 0.04
SULT1E1 -0.0001285 12675 GTEx DepMap Descartes 0.00 0.03
GAS2 -0.0001317 12767 GTEx DepMap Descartes 1.39 1.84
HHIP -0.0001327 12794 GTEx DepMap Descartes 0.18 0.30
FNDC1 -0.0001491 13238 GTEx DepMap Descartes 0.08 0.13
ABCC9 -0.0001789 14047 GTEx DepMap Descartes 0.13 0.13
RSPO3 -0.0002246 14973 GTEx DepMap Descartes 1.17 1.77
ELN -0.0002497 15395 GTEx DepMap Descartes 0.64 2.53
LRRC17 -0.0003005 16147 GTEx DepMap Descartes 0.97 4.69
CLDN11 -0.0003032 16184 GTEx DepMap Descartes 0.29 3.94
BICC1 -0.0003038 16194 GTEx DepMap Descartes 1.40 0.92
PRICKLE1 -0.0003702 16949 GTEx DepMap Descartes 0.50 0.78
CDH11 -0.0003727 16976 GTEx DepMap Descartes 2.42 2.46
ITGA11 -0.0003734 16981 GTEx DepMap Descartes 0.04 0.05
IGFBP3 -0.0004665 17707 GTEx DepMap Descartes 1.80 31.20
MGP -0.0005423 18075 GTEx DepMap Descartes 2.06 91.98
ACTA2 -0.0005510 18102 GTEx DepMap Descartes 8.80 59.30
SCARA5 -0.0005661 18170 GTEx DepMap Descartes 0.07 0.11
ADAMTS2 -0.0005670 18175 GTEx DepMap Descartes 0.21 0.15
PAMR1 -0.0006653 18494 GTEx DepMap Descartes 0.19 0.36
CD248 -0.0006942 18580 GTEx DepMap Descartes 0.73 45.23


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.04e-01
Mean rank of genes in gene set: 9891.88
Median rank of genes in gene set: 8972
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HTATSF1 0.0007195 1422 GTEx DepMap Descartes 3.35 33.08
PCSK1N 0.0002272 3841 GTEx DepMap Descartes 1.68 53.70
TMEM130 0.0001912 4221 GTEx DepMap Descartes 0.03 0.12
PCSK2 0.0001310 5135 GTEx DepMap Descartes 0.25 0.09
MGAT4C 0.0001081 5515 GTEx DepMap Descartes 0.03 0.01
INSM1 0.0000872 5900 GTEx DepMap Descartes 0.29 13.26
TBX20 0.0000756 6152 GTEx DepMap Descartes 0.18 0.38
FAM155A 0.0000717 6257 GTEx DepMap Descartes 0.10 0.03
SLC18A1 0.0000539 6717 GTEx DepMap Descartes 0.10 0.30
CHGA 0.0000500 6813 GTEx DepMap Descartes 0.62 10.39
TENM1 0.0000406 7071 GTEx DepMap Descartes 0.04 0.01
DGKK 0.0000365 7180 GTEx DepMap Descartes 0.19 0.19
KSR2 0.0000314 7325 GTEx DepMap Descartes 0.06 0.02
CHGB 0.0000224 7612 GTEx DepMap Descartes 0.98 11.01
TIAM1 0.0000175 7763 GTEx DepMap Descartes 1.45 0.43
CCSER1 0.0000162 7798 GTEx DepMap Descartes 0.09 0.01
FGF14 0.0000042 8250 GTEx DepMap Descartes 0.01 0.00
SCG2 0.0000022 8315 GTEx DepMap Descartes 0.04 1.06
SPOCK3 -0.0000079 8658 GTEx DepMap Descartes 0.23 0.09
ST18 -0.0000131 8874 GTEx DepMap Descartes 0.08 0.03
CDH12 -0.0000135 8887 GTEx DepMap Descartes 0.02 0.00
EML6 -0.0000185 9057 GTEx DepMap Descartes 0.03 0.02
AGBL4 -0.0000374 9703 GTEx DepMap Descartes 0.00 0.00
ARC -0.0000410 9833 GTEx DepMap Descartes 0.05 1.87
UNC80 -0.0000466 10034 GTEx DepMap Descartes 0.07 0.04
SLC24A2 -0.0000594 10484 GTEx DepMap Descartes 0.02 0.01
CDH18 -0.0000638 10622 GTEx DepMap Descartes 0.01 0.00
KCTD16 -0.0000911 11545 GTEx DepMap Descartes 0.00 0.00
PNMT -0.0001070 12034 GTEx DepMap Descartes 0.03 2.04
GRM7 -0.0001248 12554 GTEx DepMap Descartes 0.02 0.00


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 11860.36
Median rank of genes in gene set: 12911
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EPB41 0.0004371 2358 GTEx DepMap Descartes 1.84 1.47
SPTB 0.0003234 3015 GTEx DepMap Descartes 0.11 0.14
GCLC 0.0002984 3199 GTEx DepMap Descartes 0.62 1.74
TRAK2 0.0002163 3931 GTEx DepMap Descartes 0.41 0.75
RHAG 0.0002007 4109 GTEx DepMap Descartes 0.01 0.03
XPO7 0.0001458 4882 GTEx DepMap Descartes 1.41 1.51
TMEM56 0.0000908 5823 GTEx DepMap Descartes 0.04 0.06
TSPAN5 0.0000900 5841 GTEx DepMap Descartes 0.84 0.65
ANK1 0.0000599 6558 GTEx DepMap Descartes 0.33 0.24
SPECC1 -0.0000203 9134 GTEx DepMap Descartes 0.63 0.31
MARCH3 -0.0000398 9785 GTEx DepMap Descartes 0.03 0.03
SLC25A21 -0.0000553 10353 GTEx DepMap Descartes 0.01 0.00
TMCC2 -0.0000591 10471 GTEx DepMap Descartes 0.27 1.01
RAPGEF2 -0.0000740 10968 GTEx DepMap Descartes 0.65 0.38
CPOX -0.0000824 11259 GTEx DepMap Descartes 0.90 2.07
TFR2 -0.0000917 11570 GTEx DepMap Descartes 0.02 0.10
RHD -0.0001132 12214 GTEx DepMap Descartes 0.04 0.13
SPTA1 -0.0001292 12697 GTEx DepMap Descartes 0.01 0.01
DENND4A -0.0001448 13125 GTEx DepMap Descartes 0.15 0.17
GYPC -0.0001688 13789 GTEx DepMap Descartes 0.38 1.73
EPB42 -0.0001718 13864 GTEx DepMap Descartes 0.00 0.01
BLVRB -0.0001810 14095 GTEx DepMap Descartes 1.13 8.66
SNCA -0.0001935 14382 GTEx DepMap Descartes 0.17 0.16
HEMGN -0.0002073 14659 GTEx DepMap Descartes 0.02 0.12
RGS6 -0.0002513 15423 GTEx DepMap Descartes 0.03 0.01
SLC4A1 -0.0002866 15959 GTEx DepMap Descartes 0.00 0.00
MICAL2 -0.0003264 16489 GTEx DepMap Descartes 0.15 0.09
GYPA -0.0003325 16560 GTEx DepMap Descartes 0.01 0.06
SLC25A37 -0.0003343 16582 GTEx DepMap Descartes 0.45 1.10
CR1L -0.0003545 16789 GTEx DepMap Descartes 1.13 4.22


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13672.98
Median rank of genes in gene set: 13676.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
WWP1 0.0003056 3151 GTEx DepMap Descartes 1.00 1.24
HRH1 0.0002245 3863 GTEx DepMap Descartes 0.00 0.00
RBPJ 0.0001956 4162 GTEx DepMap Descartes 1.75 1.21
ADAP2 0.0001601 4658 GTEx DepMap Descartes 0.01 0.04
CPVL 0.0001596 4667 GTEx DepMap Descartes 0.00 0.00
MARCH1 0.0000712 6270 GTEx DepMap Descartes 0.02 0.00
MS4A4A -0.0000127 8859 GTEx DepMap Descartes 0.00 0.00
CYBB -0.0000582 10456 GTEx DepMap Descartes 0.04 0.07
CSF1R -0.0000652 10672 GTEx DepMap Descartes 0.05 0.20
SLC9A9 -0.0000744 10987 GTEx DepMap Descartes 0.10 0.02
MS4A7 -0.0000885 11470 GTEx DepMap Descartes 0.00 0.02
FMN1 -0.0001025 11900 GTEx DepMap Descartes 0.18 0.05
C1QC -0.0001211 12458 GTEx DepMap Descartes 0.11 4.04
C1QB -0.0001249 12558 GTEx DepMap Descartes 0.13 2.50
RNASE1 -0.0001270 12631 GTEx DepMap Descartes 0.00 0.10
C1QA -0.0001348 12855 GTEx DepMap Descartes 0.08 3.06
SFMBT2 -0.0001349 12859 GTEx DepMap Descartes 0.07 0.04
HCK -0.0001366 12921 GTEx DepMap Descartes 0.05 0.12
CTSS -0.0001419 13061 GTEx DepMap Descartes 0.05 0.19
CD14 -0.0001439 13103 GTEx DepMap Descartes 0.03 1.87
SLCO2B1 -0.0001569 13474 GTEx DepMap Descartes 0.01 0.03
MPEG1 -0.0001723 13879 GTEx DepMap Descartes 0.02 0.39
MSR1 -0.0002280 15028 GTEx DepMap Descartes 0.00 0.01
SPP1 -0.0002612 15586 GTEx DepMap Descartes 0.03 0.55
CTSC -0.0002619 15594 GTEx DepMap Descartes 0.59 2.04
ATP8B4 -0.0002723 15755 GTEx DepMap Descartes 0.00 0.00
RGL1 -0.0002767 15824 GTEx DepMap Descartes 0.55 0.32
MERTK -0.0003588 16837 GTEx DepMap Descartes 0.19 0.24
IFNGR1 -0.0003875 17115 GTEx DepMap Descartes 0.39 3.00
LGMN -0.0004162 17348 GTEx DepMap Descartes 0.91 2.39


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13974.53
Median rank of genes in gene set: 15082
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCKS 0.0012617 715 GTEx DepMap Descartes 22.14 565.56
HMGA2 0.0009282 1053 GTEx DepMap Descartes 15.79 18.97
FIGN 0.0004566 2269 GTEx DepMap Descartes 1.18 1.43
NRXN1 0.0002721 3416 GTEx DepMap Descartes 0.52 0.05
ERBB4 0.0001375 5013 GTEx DepMap Descartes 0.07 0.01
XKR4 0.0000432 6989 GTEx DepMap Descartes 0.04 NA
PAG1 0.0000168 7781 GTEx DepMap Descartes 0.39 0.34
SCN7A -0.0000190 9075 GTEx DepMap Descartes 0.03 0.03
GRIK3 -0.0000347 9616 GTEx DepMap Descartes 0.04 0.02
NRXN3 -0.0000536 10297 GTEx DepMap Descartes 0.26 0.01
IL1RAPL2 -0.0000553 10352 GTEx DepMap Descartes 0.02 0.00
PPP2R2B -0.0000646 10652 GTEx DepMap Descartes 0.56 0.19
SOX10 -0.0000797 11179 GTEx DepMap Descartes 0.71 11.60
ERBB3 -0.0000858 11377 GTEx DepMap Descartes 1.16 6.05
STARD13 -0.0001130 12209 GTEx DepMap Descartes 0.33 0.23
TRPM3 -0.0001449 13129 GTEx DepMap Descartes 0.05 0.01
LRRTM4 -0.0001490 13236 GTEx DepMap Descartes 0.02 0.00
SLC35F1 -0.0001568 13471 GTEx DepMap Descartes 0.32 0.11
LAMC1 -0.0001624 13616 GTEx DepMap Descartes 1.58 1.57
MDGA2 -0.0001679 13756 GTEx DepMap Descartes 0.11 0.02
SORCS1 -0.0001824 14131 GTEx DepMap Descartes 0.27 0.07
PLCE1 -0.0001853 14189 GTEx DepMap Descartes 0.48 0.24
CDH19 -0.0001978 14456 GTEx DepMap Descartes 0.17 0.26
IL1RAPL1 -0.0002312 15082 GTEx DepMap Descartes 0.12 0.01
GAS7 -0.0002375 15197 GTEx DepMap Descartes 0.55 0.31
PLP1 -0.0002648 15636 GTEx DepMap Descartes 1.26 10.80
SOX5 -0.0003848 17084 GTEx DepMap Descartes 0.88 0.16
PMP22 -0.0004226 17405 GTEx DepMap Descartes 2.39 14.54
FAM134B -0.0004807 17785 GTEx DepMap Descartes 0.30 NA
DST -0.0006166 18351 GTEx DepMap Descartes 6.47 1.92


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.38e-01
Mean rank of genes in gene set: 10912.89
Median rank of genes in gene set: 11167
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TPM4 0.0013743 647 GTEx DepMap Descartes 6.37 35.57
LIMS1 0.0013139 682 GTEx DepMap Descartes 2.58 3.28
ACTB 0.0012166 750 GTEx DepMap Descartes 135.53 5103.42
ACTN1 0.0007455 1356 GTEx DepMap Descartes 2.44 3.37
SPN 0.0006649 1553 GTEx DepMap Descartes 0.01 0.14
PRKAR2B 0.0005349 1966 GTEx DepMap Descartes 1.02 1.22
FLI1 0.0002916 3257 GTEx DepMap Descartes 0.36 0.52
UBASH3B 0.0001604 4654 GTEx DepMap Descartes 0.28 0.30
TLN1 0.0001243 5230 GTEx DepMap Descartes 3.79 15.79
RAP1B 0.0001040 5601 GTEx DepMap Descartes 3.60 15.45
HIPK2 0.0000904 5829 GTEx DepMap Descartes 1.93 1.23
STOM 0.0000771 6115 GTEx DepMap Descartes 0.21 1.38
ARHGAP6 0.0000549 6681 GTEx DepMap Descartes 0.12 0.03
PSTPIP2 0.0000443 6953 GTEx DepMap Descartes 0.00 0.00
MMRN1 0.0000111 7983 GTEx DepMap Descartes 0.03 0.05
ZYX -0.0000156 8957 GTEx DepMap Descartes 3.73 45.76
FERMT3 -0.0000305 9470 GTEx DepMap Descartes 0.04 0.25
STON2 -0.0000430 9906 GTEx DepMap Descartes 0.29 0.18
PDE3A -0.0000442 9946 GTEx DepMap Descartes 0.33 0.18
DOK6 -0.0000498 10159 GTEx DepMap Descartes 0.01 0.00
MED12L -0.0000499 10160 GTEx DepMap Descartes 0.11 0.04
PPBP -0.0000501 10171 GTEx DepMap Descartes 0.01 0.82
MYH9 -0.0000672 10742 GTEx DepMap Descartes 3.59 4.54
TRPC6 -0.0000795 11167 GTEx DepMap Descartes 0.01 0.01
FLNA -0.0001032 11923 GTEx DepMap Descartes 6.43 29.25
MCTP1 -0.0001106 12137 GTEx DepMap Descartes 0.01 0.00
P2RX1 -0.0001272 12636 GTEx DepMap Descartes 0.00 0.03
BIN2 -0.0001562 13447 GTEx DepMap Descartes 0.01 0.03
PF4 -0.0001952 14410 GTEx DepMap Descartes 0.10 16.03
SLC2A3 -0.0001963 14430 GTEx DepMap Descartes 2.59 3.06


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.03e-01
Mean rank of genes in gene set: 9221.45
Median rank of genes in gene set: 8442
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MSN 0.0006343 1640 GTEx DepMap Descartes 1.26 2.33
LEF1 0.0005666 1849 GTEx DepMap Descartes 2.57 2.61
PDE3B 0.0005587 1873 GTEx DepMap Descartes 0.31 0.39
ETS1 0.0004512 2293 GTEx DepMap Descartes 0.63 0.75
IKZF1 0.0004360 2363 GTEx DepMap Descartes 0.02 0.02
STK39 0.0002759 3379 GTEx DepMap Descartes 0.74 0.42
NKG7 0.0002719 3420 GTEx DepMap Descartes 0.00 0.60
EVL 0.0002653 3475 GTEx DepMap Descartes 4.39 4.58
SP100 0.0002287 3827 GTEx DepMap Descartes 0.00 0.01
GNG2 0.0001577 4703 GTEx DepMap Descartes 1.57 2.00
BACH2 0.0001459 4880 GTEx DepMap Descartes 0.64 0.24
ABLIM1 0.0001371 5024 GTEx DepMap Descartes 2.44 0.83
SKAP1 0.0001281 5180 GTEx DepMap Descartes 0.05 0.02
WIPF1 0.0001233 5257 GTEx DepMap Descartes 0.35 0.53
FYN 0.0001046 5584 GTEx DepMap Descartes 1.59 1.13
FOXP1 0.0000937 5775 GTEx DepMap Descartes 6.40 1.33
CD44 0.0000657 6413 GTEx DepMap Descartes 0.24 0.31
TMSB10 0.0000628 6481 GTEx DepMap Descartes 62.11 5267.11
RCSD1 0.0000608 6532 GTEx DepMap Descartes 0.52 1.05
FAM65B 0.0000436 6976 GTEx DepMap Descartes 0.08 NA
ARHGAP15 0.0000081 8086 GTEx DepMap Descartes 0.02 0.00
RAP1GAP2 -0.0000112 8798 GTEx DepMap Descartes 0.04 0.02
LCP1 -0.0000113 8803 GTEx DepMap Descartes 0.12 0.13
DOCK10 -0.0000225 9205 GTEx DepMap Descartes 0.20 0.12
CELF2 -0.0000291 9428 GTEx DepMap Descartes 2.95 0.39
SCML4 -0.0000749 11008 GTEx DepMap Descartes 0.01 0.02
ARID5B -0.0000812 11218 GTEx DepMap Descartes 1.73 1.17
PTPRC -0.0000988 11783 GTEx DepMap Descartes 0.01 0.01
SORL1 -0.0001349 12861 GTEx DepMap Descartes 0.52 0.37
PRKCH -0.0001564 13458 GTEx DepMap Descartes 0.47 0.25


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.99e-03
Mean rank of genes in gene set: 1364.67
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0138475 12 GTEx DepMap Descartes 25.38 128.60
MKI67 0.0133305 16 GTEx DepMap Descartes 13.00 72.38
S100A9 0.0002043 4066 GTEx DepMap Descartes 0.02 0.49


Cycling cells: Cycling B cells (curated markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.22e-03
Mean rank of genes in gene set: 14
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0138475 12 GTEx DepMap Descartes 25.38 128.60
MKI67 0.0133305 16 GTEx DepMap Descartes 13.00 72.38


Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.22e-03
Mean rank of genes in gene set: 14
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0138475 12 GTEx DepMap Descartes 25.38 128.60
MKI67 0.0133305 16 GTEx DepMap Descartes 13.00 72.38