Program: 15. Neuroblastoma #6.

Program: 15. Neuroblastoma #6.

Program description and justification of annotation: 15.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot
## Warning in asMethod(object): sparse->dense coercion: allocating vector of size
## 1.3 GiB

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 KCNQ5 0.0088233 potassium voltage-gated channel subfamily Q member 5 GTEx DepMap Descartes 2.81 2200.28
2 TMEM132D 0.0085769 transmembrane protein 132D GTEx DepMap Descartes 0.79 706.88
3 ANK2 0.0082386 ankyrin 2 GTEx DepMap Descartes 2.11 721.71
4 UNC5C 0.0079972 unc-5 netrin receptor C GTEx DepMap Descartes 1.76 983.26
5 EYA4 0.0073514 EYA transcriptional coactivator and phosphatase 4 GTEx DepMap Descartes 0.67 656.96
6 MEIS2 0.0072760 Meis homeobox 2 GTEx DepMap Descartes 1.09 1000.60
7 GULP1 0.0072056 GULP PTB domain containing engulfment adaptor 1 GTEx DepMap Descartes 0.64 542.14
8 CREB5 0.0068622 cAMP responsive element binding protein 5 GTEx DepMap Descartes 1.08 620.09
9 PTPRM 0.0067483 protein tyrosine phosphatase receptor type M GTEx DepMap Descartes 0.89 763.60
10 CACNA2D1 0.0065057 calcium voltage-gated channel auxiliary subunit alpha2delta 1 GTEx DepMap Descartes 1.58 1084.35
11 LRRC7 0.0061752 leucine rich repeat containing 7 GTEx DepMap Descartes 0.66 128.43
12 GLCCI1 0.0061513 glucocorticoid induced 1 GTEx DepMap Descartes 1.03 1108.08
13 GRIK2 0.0058464 glutamate ionotropic receptor kainate type subunit 2 GTEx DepMap Descartes 1.60 1732.39
14 ALK 0.0057726 ALK receptor tyrosine kinase GTEx DepMap Descartes 1.48 1024.79
15 PTMA 0.0057186 prothymosin alpha GTEx DepMap Descartes 1.94 6654.59
16 ICA1 0.0057180 islet cell autoantigen 1 GTEx DepMap Descartes 1.17 2100.25
17 MYCN 0.0055041 MYCN proto-oncogene, bHLH transcription factor GTEx DepMap Descartes 0.45 1055.08
18 CADM2 0.0054497 cell adhesion molecule 2 GTEx DepMap Descartes 0.54 318.62
19 FGF14 0.0052653 fibroblast growth factor 14 GTEx DepMap Descartes 1.40 541.28
20 BCAT1 0.0050512 branched chain amino acid transaminase 1 GTEx DepMap Descartes 0.28 184.69
21 CCSER1 0.0047247 coiled-coil serine rich protein 1 GTEx DepMap Descartes 0.78 NA
22 BMPR1B 0.0047136 bone morphogenetic protein receptor type 1B GTEx DepMap Descartes 1.28 1040.64
23 SYT1 0.0046443 synaptotagmin 1 GTEx DepMap Descartes 1.42 1481.92
24 CUX2 0.0045374 cut like homeobox 2 GTEx DepMap Descartes 0.36 227.61
25 KIF21A 0.0042356 kinesin family member 21A GTEx DepMap Descartes 0.54 397.53
26 GNG4 0.0042212 G protein subunit gamma 4 GTEx DepMap Descartes 0.43 406.12
27 MAP2 0.0041866 microtubule associated protein 2 GTEx DepMap Descartes 0.82 412.31
28 NCAM2 0.0041530 neural cell adhesion molecule 2 GTEx DepMap Descartes 0.78 492.38
29 EYA1 0.0040750 EYA transcriptional coactivator and phosphatase 1 GTEx DepMap Descartes 0.42 515.06
30 RBMS1 0.0039592 RNA binding motif single stranded interacting protein 1 GTEx DepMap Descartes 0.53 629.40
31 TMSB10 0.0039046 thymosin beta 10 GTEx DepMap Descartes 2.23 27186.09
32 CHRM3 0.0038856 cholinergic receptor muscarinic 3 GTEx DepMap Descartes 0.49 254.37
33 TMEM163 0.0038559 transmembrane protein 163 GTEx DepMap Descartes 0.18 198.04
34 SLC6A5 0.0035805 solute carrier family 6 member 5 GTEx DepMap Descartes 0.07 62.78
35 HS6ST2 0.0035773 heparan sulfate 6-O-sulfotransferase 2 GTEx DepMap Descartes 0.28 300.53
36 GAPDH 0.0035530 glyceraldehyde-3-phosphate dehydrogenase GTEx DepMap Descartes 0.74 2422.97
37 DACH1 0.0035339 dachshund family transcription factor 1 GTEx DepMap Descartes 0.25 269.39
38 TMEM132C 0.0035149 transmembrane protein 132C GTEx DepMap Descartes 0.91 764.40
39 TCF4 0.0033410 transcription factor 4 GTEx DepMap Descartes 1.25 714.62
40 CPNE8 0.0033355 copine 8 GTEx DepMap Descartes 0.26 374.47
41 ENAH 0.0032456 ENAH actin regulator GTEx DepMap Descartes 0.52 201.15
42 TEAD1 0.0032107 TEA domain transcription factor 1 GTEx DepMap Descartes 0.45 228.94
43 FAM163A 0.0031902 family with sequence similarity 163 member A GTEx DepMap Descartes 0.43 632.27
44 GALNTL6 0.0031455 polypeptide N-acetylgalactosaminyltransferase like 6 GTEx DepMap Descartes 0.23 309.94
45 CNTNAP4 0.0031105 contactin associated protein family member 4 GTEx DepMap Descartes 0.34 293.32
46 KIT 0.0031073 KIT proto-oncogene, receptor tyrosine kinase GTEx DepMap Descartes 0.08 98.19
47 EML6 0.0030917 EMAP like 6 GTEx DepMap Descartes 0.25 126.69
48 ASTN1 0.0030906 astrotactin 1 GTEx DepMap Descartes 0.21 145.06
49 ADAM22 0.0030749 ADAM metallopeptidase domain 22 GTEx DepMap Descartes 0.33 177.07
50 SPOCK3 0.0030642 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 GTEx DepMap Descartes 0.15 295.93


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UMAP plots showing activity of gene expression program identified in community:15. Neuroblastoma #6

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
LAKE_ADULT_KIDNEY_C23_ENDOTHELIAL_CELLS_AVR 5.68e-07 17.09 6.36 2.80e-04 3.81e-04
7MEIS2, PTPRM, PTMA, RBMS1, TMSB10, GAPDH, TCF4
 126
DESCARTES_MAIN_FETAL_INHIBITORY_INTERNEURONS 2.70e-04 27.48 5.18 1.21e-02 1.81e-01
3UNC5C, SLC6A5, KIT
 32
LAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES 1.53e-05 13.01 4.45 1.72e-03 1.03e-02
6MEIS2, PTPRM, CACNA2D1, RBMS1, CHRM3, TCF4
 137
LAKE_ADULT_KIDNEY_C21_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_B 5.14e-05 14.17 4.30 4.31e-03 3.45e-02
5GULP1, GLCCI1, BMPR1B, KIF21A, DACH1
 103
LAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR 2.74e-05 11.67 4.00 2.63e-03 1.84e-02
6MEIS2, PTPRM, PTMA, TMSB10, CHRM3, TCF4
 152
DESCARTES_FETAL_STOMACH_ENS_NEURONS 2.04e-04 15.52 3.95 9.79e-03 1.37e-01
4UNC5C, SYT1, CUX2, FAM163A
 74
MANNO_MIDBRAIN_NEUROTYPES_HSERT 8.35e-07 8.04 3.69 2.80e-04 5.60e-04
11ANK2, PTPRM, GRIK2, ICA1, FGF14, CCSER1, SYT1, CNTNAP4, KIT, ADAM22, SPOCK3
 450
LAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS 6.36e-05 9.97 3.42 4.74e-03 4.27e-02
6UNC5C, MEIS2, PTPRM, CACNA2D1, RBMS1, TCF4
 177
DESCARTES_FETAL_HEART_VISCERAL_NEURONS 3.79e-04 13.08 3.35 1.49e-02 2.54e-01
4EYA4, GNG4, FAM163A, SPOCK3
 87
MENON_FETAL_KIDNEY_0_CAP_MESENCHYME_CELLS 4.31e-04 12.63 3.23 1.52e-02 2.89e-01
4MEIS2, PTMA, DACH1, ENAH
 90
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 1.54e-05 7.22 3.06 1.72e-03 1.03e-02
9ANK2, KIF21A, MAP2, EYA1, DACH1, CPNE8, CNTNAP4, ADAM22, SPOCK3
 389
LAKE_ADULT_KIDNEY_C2_PODOCYTES 1.69e-04 8.27 2.85 9.46e-03 1.14e-01
6UNC5C, GULP1, RBMS1, DACH1, CPNE8, TEAD1
 212
DESCARTES_FETAL_LUNG_VISCERAL_NEURONS 1.69e-04 8.27 2.85 9.46e-03 1.14e-01
6LRRC7, ALK, CUX2, FAM163A, CNTNAP4, ASTN1
 212
HAY_BONE_MARROW_STROMAL 3.29e-06 5.84 2.84 7.35e-04 2.21e-03
13ANK2, UNC5C, EYA4, MEIS2, GULP1, PTPRM, CACNA2D1, NCAM2, EYA1, RBMS1, TMEM132C, ENAH, TEAD1
 765
DESCARTES_FETAL_INTESTINE_ENS_NEURONS 3.98e-04 8.96 2.74 1.49e-02 2.67e-01
5SYT1, CUX2, NCAM2, FAM163A, ASTN1
 160
MANNO_MIDBRAIN_NEUROTYPES_HNBGABA 8.52e-06 5.72 2.71 1.43e-03 5.72e-03
12ANK2, EYA4, MEIS2, LRRC7, GRIK2, CADM2, FGF14, CCSER1, SYT1, KIF21A, MAP2, SPOCK3
 703
HU_FETAL_RETINA_AMACRINE 2.06e-03 13.07 2.53 6.28e-02 1.00e+00
3MEIS2, SYT1, MAP2
 64
GAO_LARGE_INTESTINE_ADULT_CA_ENTEROENDOCRINE_CELLS 1.89e-04 6.67 2.51 9.73e-03 1.27e-01
7TMEM132D, ANK2, GULP1, CACNA2D1, BMPR1B, SYT1, MAP2
 312
DESCARTES_FETAL_THYMUS_THYMIC_EPITHELIAL_CELLS 3.64e-04 7.13 2.46 1.49e-02 2.44e-01
6EYA4, EYA1, TMEM163, HS6ST2, FAM163A, EML6
 245
DESCARTES_FETAL_ADRENAL_CHROMAFFIN_CELLS 1.22e-03 9.45 2.43 4.10e-02 8.20e-01
4EYA4, ALK, EYA1, TMEM132C
 119

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_UV_RESPONSE_DN 1.90e-02 5.66 1.11 9.50e-01 9.50e-01
3PTPRM, ICA1, KIT
 144
HALLMARK_MTORC1_SIGNALING 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2BCAT1, GAPDH
 200
HALLMARK_HEDGEHOG_SIGNALING 1.34e-01 7.29 0.18 1.00e+00 1.00e+00
1UNC5C
 36
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1ICA1
 96
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 1.00e+00 1.00e+00
1BMPR1B
 100
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1BMPR1B
 158
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1GAPDH
 200
HALLMARK_G2M_CHECKPOINT 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1MEIS2
 200
HALLMARK_APICAL_JUNCTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CADM2
 200
HALLMARK_XENOBIOTIC_METABOLISM 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1BCAT1
 200
HALLMARK_GLYCOLYSIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1HS6ST2
 200
HALLMARK_ALLOGRAFT_REJECTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1BCAT1
 200
HALLMARK_KRAS_SIGNALING_UP 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1MYCN
 200
HALLMARK_KRAS_SIGNALING_DN 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1BMPR1B
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_MITOTIC_SPINDLE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 199
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 87

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.07e-02 3.80 0.75 1.00e+00 1.00e+00
3FGF14, CHRM3, ENAH
 213
KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 4.29e-02 25.48 0.58 1.00e+00 1.00e+00
1BCAT1
 11
KEGG_CELL_ADHESION_MOLECULES_CAMS 9.66e-02 3.98 0.46 1.00e+00 1.00e+00
2PTPRM, NCAM2
 133
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1BCAT1
 16
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE 9.85e-02 10.19 0.24 1.00e+00 1.00e+00
1HS6ST2
 26
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 2.77e-01 1.98 0.23 1.00e+00 1.00e+00
2BMPR1B, KIT
 265
KEGG_MAPK_SIGNALING_PATHWAY 2.80e-01 1.97 0.23 1.00e+00 1.00e+00
2CACNA2D1, FGF14
 267
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.87e-01 1.93 0.23 1.00e+00 1.00e+00
2GRIK2, CHRM3
 272
KEGG_O_GLYCAN_BIOSYNTHESIS 1.13e-01 8.79 0.21 1.00e+00 1.00e+00
1GALNTL6
 30
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2FGF14, KIT
 325
KEGG_PRION_DISEASES 1.30e-01 7.50 0.18 1.00e+00 1.00e+00
1NCAM2
 35
KEGG_TYPE_I_DIABETES_MELLITUS 1.57e-01 6.07 0.15 1.00e+00 1.00e+00
1ICA1
 43
KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1BCAT1
 44
KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1CREB5
 44
KEGG_ACUTE_MYELOID_LEUKEMIA 2.03e-01 4.55 0.11 1.00e+00 1.00e+00
1KIT
 57
KEGG_GLYCOLYSIS_GLUCONEOGENESIS 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1GAPDH
 62
KEGG_MELANOMA 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1FGF14
 71
KEGG_ADHERENS_JUNCTION 2.52e-01 3.54 0.09 1.00e+00 1.00e+00
1PTPRM
 73
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1CACNA2D1
 74
KEGG_CARDIAC_MUSCLE_CONTRACTION 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1CACNA2D1
 79

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr4q22 2.66e-03 11.90 2.31 7.39e-01 7.39e-01
3UNC5C, CCSER1, BMPR1B
 70
chr12q12 2.21e-02 9.30 1.07 1.00e+00 1.00e+00
2KIF21A, CPNE8
 58
chr7p21 4.26e-02 6.43 0.74 1.00e+00 1.00e+00
2GLCCI1, ICA1
 83
chr12q24 1.91e-01 2.06 0.41 1.00e+00 1.00e+00
3TMEM132D, CUX2, TMEM132C
 390
chr1q25 1.31e-01 3.30 0.38 1.00e+00 1.00e+00
2FAM163A, ASTN1
 160
chr7q21 1.36e-01 3.21 0.38 1.00e+00 1.00e+00
2CACNA2D1, ADAM22
 164
chr1q42 2.27e-01 2.28 0.27 1.00e+00 1.00e+00
2GNG4, ENAH
 230
chr2q34 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1MAP2
 45
chr6q16 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1GRIK2
 52
chr13q33 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1FGF14
 55
chr15q14 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1MEIS2
 56
chr6q13 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1KCNQ5
 56
chr1q43 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1CHRM3
 60
chr3p12 2.31e-01 3.92 0.10 1.00e+00 1.00e+00
1CADM2
 66
chr8q13 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1EYA1
 71
chr2p24 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1MYCN
 74
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1KIT
 79
chr4q25 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1ANK2
 87
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1CREB5
 96
chr16q23 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1CNTNAP4
 104

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
EVI1_06 9.91e-05 39.79 7.33 5.62e-02 1.12e-01
3CREB5, MAP2, TCF4
 23
YAATNRNNNYNATT_UNKNOWN 5.38e-05 14.03 4.25 5.62e-02 6.09e-02
5CREB5, BMPR1B, EYA1, RBMS1, CNTNAP4
 104
CART1_01 2.55e-04 7.64 2.63 7.23e-02 2.89e-01
6MEIS2, CREB5, PTMA, CADM2, EYA1, CNTNAP4
 229
CDP_02 9.45e-04 10.15 2.61 1.37e-01 1.00e+00
4PTMA, SYT1, DACH1, TCF4
 111
MEF2_04 4.74e-03 21.66 2.42 1.99e-01 1.00e+00
2EYA1, TMEM163
 26
CREBP1_01 7.29e-04 7.80 2.39 1.37e-01 8.26e-01
5UNC5C, CREB5, FGF14, EYA1, HS6ST2
 183
NFAT_Q4_01 5.69e-04 6.53 2.25 1.29e-01 6.45e-01
6KCNQ5, CREB5, CADM2, FGF14, SLC6A5, TEAD1
 267
TGATTTRY_GFI1_01 9.64e-04 5.88 2.03 1.37e-01 1.00e+00
6MEIS2, CREB5, CADM2, FGF14, SLC6A5, TEAD1
 296
OCT1_03 2.21e-03 6.01 1.85 1.77e-01 1.00e+00
5MEIS2, CREB5, EYA1, SLC6A5, TCF4
 236
SREBP1_02 5.05e-03 9.38 1.83 2.04e-01 1.00e+00
3PTMA, CHRM3, HS6ST2
 88
NKX3A_01 2.29e-03 5.96 1.83 1.77e-01 1.00e+00
5CREB5, EYA1, HS6ST2, CNTNAP4, KIT
 238
BRN2_01 2.38e-03 5.91 1.81 1.77e-01 1.00e+00
5CREB5, FGF14, NCAM2, EYA1, TCF4
 240
AACTTT_UNKNOWN 1.53e-04 3.37 1.76 5.79e-02 1.74e-01
17EYA4, MEIS2, CREB5, ALK, PTMA, FGF14, GNG4, NCAM2, EYA1, RBMS1, DACH1, TCF4, CPNE8, ENAH, TEAD1, KIT, ASTN1
 1928
YY1_01 2.92e-03 5.62 1.73 1.77e-01 1.00e+00
5GRIK2, NCAM2, RBMS1, TCF4, KIT
 252
AP4_Q6_01 3.18e-03 5.51 1.69 1.77e-01 1.00e+00
5KCNQ5, ALK, MYCN, CADM2, EYA1
 257
CEBPGAMMA_Q6 3.28e-03 5.47 1.68 1.77e-01 1.00e+00
5KCNQ5, CREB5, EYA1, SLC6A5, KIT
 259
AAAYWAACM_HFH4_01 3.44e-03 5.41 1.66 1.77e-01 1.00e+00
5KCNQ5, GRIK2, CADM2, TCF4, CNTNAP4
 262
TTAYRTAA_E4BP4_01 3.79e-03 5.28 1.62 1.86e-01 1.00e+00
5UNC5C, CREB5, FGF14, EYA1, HS6ST2
 268
TGTTTGY_HNF3_Q6 1.68e-03 3.71 1.58 1.73e-01 1.00e+00
9MEIS2, CREB5, GRIK2, CADM2, FGF14, EYA1, TCF4, TEAD1, CNTNAP4
 748
NFE2_01 4.21e-03 5.14 1.58 1.97e-01 1.00e+00
5MAP2, HS6ST2, GAPDH, CPNE8, TEAD1
 275

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_POSITIVE_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY 1.54e-04 172.68 14.09 5.76e-01 1.00e+00
2CACNA2D1, FGF14
 5
GOBP_HISTONE_DEPHOSPHORYLATION 2.31e-04 129.66 11.45 5.76e-01 1.00e+00
2EYA4, EYA1
 6
GOBP_POSITIVE_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY 9.99e-04 51.89 5.39 1.00e+00 1.00e+00
2CACNA2D1, FGF14
 12
GOBP_REGULATION_OF_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY 1.37e-03 43.30 4.59 1.00e+00 1.00e+00
2CACNA2D1, FGF14
 14
GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 4.17e-04 23.45 4.45 7.80e-01 1.00e+00
3ANK2, CACNA2D1, FGF14
 37
GOBP_NEURON_CELL_CELL_ADHESION 2.03e-03 34.68 3.75 1.00e+00 1.00e+00
2NCAM2, ASTN1
 17
GOBP_RETINAL_GANGLION_CELL_AXON_GUIDANCE 2.54e-03 30.58 3.34 1.00e+00 1.00e+00
2PTPRM, BMPR1B
 19
GOBP_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY 3.10e-03 27.37 3.01 1.00e+00 1.00e+00
2GRIK2, KIT
 21
GOBP_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION 3.40e-03 26.01 2.87 1.00e+00 1.00e+00
2ANK2, CACNA2D1
 22
GOBP_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL 3.40e-03 26.01 2.87 1.00e+00 1.00e+00
2ANK2, CACNA2D1
 22
GOBP_VENTRICULAR_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION 4.74e-03 21.66 2.42 1.00e+00 1.00e+00
2ANK2, CACNA2D1
 26
GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION 5.10e-03 20.80 2.32 1.00e+00 1.00e+00
2CHRM3, KIT
 27
GOBP_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION 5.10e-03 20.80 2.32 1.00e+00 1.00e+00
2ANK2, CACNA2D1
 27
GOBP_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT 2.66e-03 11.90 2.31 1.00e+00 1.00e+00
3ANK2, CACNA2D1, FGF14
 70
GOBP_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY 2.77e-03 11.73 2.28 1.00e+00 1.00e+00
3ANK2, CACNA2D1, FGF14
 71
GOBP_BEHAVIOR 1.81e-04 5.16 2.19 5.76e-01 1.00e+00
9MEIS2, GRIK2, ALK, CUX2, DACH1, CNTNAP4, KIT, ASTN1, ADAM22
 541
GOBP_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND 7.12e-03 17.34 1.95 1.00e+00 1.00e+00
2EYA4, EYA1
 32
GOBP_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY 4.29e-03 9.97 1.94 1.00e+00 1.00e+00
3ANK2, CACNA2D1, FGF14
 83
GOBP_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION 7.55e-03 16.78 1.89 1.00e+00 1.00e+00
2ANK2, CACNA2D1
 33
GOBP_PROTEOGLYCAN_METABOLIC_PROCESS 4.89e-03 9.50 1.85 1.00e+00 1.00e+00
3BMPR1B, HS6ST2, SPOCK3
 87

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_8H_DN 1.14e-04 8.92 3.07 5.55e-01 5.55e-01
6UNC5C, MEIS2, GULP1, CREB5, BMPR1B, SYT1
 197
GSE12707_AT16L1_HYPOMORPH_VS_WT_THYMUS_UP 1.64e-03 8.69 2.24 1.00e+00 1.00e+00
4KCNQ5, ANK2, BMPR1B, CNTNAP4
 129
GSE13887_RESTING_VS_ACT_CD4_TCELL_DN 1.73e-03 8.56 2.20 1.00e+00 1.00e+00
4PTMA, NCAM2, CPNE8, FAM163A
 131
GSE21670_STAT3_KO_VS_WT_CD4_TCELL_IL6_TREATED_DN 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5GULP1, ICA1, MYCN, CPNE8, ADAM22
 200
GSE12963_ENV_NEF_VS_ENV_NEF_AND_VPR_DEFICIENT_HIV1_INF_CD4_TCELL_DN 2.89e-03 7.39 1.91 1.00e+00 1.00e+00
4ICA1, SYT1, GAPDH, CNTNAP4
 151
GSE12507_PDC_CELL_LINE_VS_IMMATUE_T_CELL_LINE_UP 3.03e-03 7.29 1.88 1.00e+00 1.00e+00
4ICA1, BCAT1, GAPDH, TCF4
 153
GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_3H_UP 6.24e-03 5.91 1.53 1.00e+00 1.00e+00
4CREB5, CACNA2D1, MYCN, BCAT1
 188
GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_IFNAR_KO_DN 6.70e-03 5.78 1.50 1.00e+00 1.00e+00
4TMEM132D, MEIS2, GAPDH, CNTNAP4
 192
GSE8515_CTRL_VS_IL6_4H_STIM_MAC_DN 7.07e-03 5.69 1.47 1.00e+00 1.00e+00
4MEIS2, ALK, SLC6A5, KIT
 195
GSE46606_UNSTIM_VS_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_UP 7.07e-03 5.69 1.47 1.00e+00 1.00e+00
4GLCCI1, SYT1, EYA1, ADAM22
 195
GSE28783_ANTI_MIR33_VS_UNTREATED_ATHEROSCLEROSIS_MACROPHAGE_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4GULP1, GNG4, TCF4, KIT
 199
GSE41176_WT_VS_TAK1_KO_UNSTIM_BCELL_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4GRIK2, ALK, CUX2, SLC6A5
 199
GSE27786_NKCELL_VS_NEUTROPHIL_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4GRIK2, CCSER1, CHRM3, TEAD1
 200
GSE21380_NON_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4ICA1, FGF14, CHRM3, TMEM163
 200
GSE43863_TFH_VS_LY6C_INT_CXCR5POS_MEMORY_CD4_TCELL_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4CADM2, BMPR1B, CHRM3, TMEM132C
 200
GSE12839_CTRL_VS_IL12_TREATED_PBMC_DN 1.34e-02 6.49 1.27 1.00e+00 1.00e+00
3ANK2, LRRC7, SLC6A5
 126
GSE35543_IN_VIVO_NTREG_VS_IN_VITRO_ITREG_DN 3.74e-02 4.31 0.85 1.00e+00 1.00e+00
3UNC5C, TMEM163, CPNE8
 188
GSE26928_CENTR_MEMORY_VS_CXCR5_POS_CD4_TCELL_DN 3.79e-02 4.29 0.85 1.00e+00 1.00e+00
3GLCCI1, CCSER1, ADAM22
 189
GSE26928_EFF_MEMORY_VS_CXCR5_POS_CD4_TCELL_UP 3.84e-02 4.27 0.84 1.00e+00 1.00e+00
3PTMA, KIF21A, EML6
 190
GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_DN 3.84e-02 4.27 0.84 1.00e+00 1.00e+00
3TMEM132D, MEIS2, CNTNAP4
 190

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MEIS2 6 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
GULP1 7 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
CREB5 8 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ALK 14 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade
MYCN 17 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CUX2 24 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
DACH1 37 Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Binds with consensus AAWANAAAWAAWT and AATACAATTAAAT as strongest target sequences based on EMSA and SELEX (PMID: 20351289). Protein contains a winged helix structural domain (PMID: 12057194)
TCF4 39 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TEAD1 42 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
KIT 46 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HNRNPD 54 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1WTB)
FOXO3 64 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HDAC2 66 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Histone deacetylase; likely to be a transcriptional cofactor
PCBP1 67 No ssDNA/RNA binding Not a DNA binding protein No motif None Crystal structure shows it binds ssDNA (PDB: 1ZTG).
PPP3CA 93 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PCBP2 95 No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is an RBP. Structure (PDB:2PQU) is with single stranded DNA
CXXC4 108 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds unmethylated CpG-rich sequences: (PMID: 23563267).
NPM1 117 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for sequence-specific DNA-binding (PMID: 2223875)
MLLT11 123 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NFIB 124 Yes Known motif Monomer or homomultimer High-throughput in vitro None None

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB13_CTAACTTAGCCGCCTA-1 Neurons:adrenal_medulla_cell_line 0.23 916.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-22: 0.29
NB08_CGAACATGTTACCGAT-1 Neurons:adrenal_medulla_cell_line 0.19 687.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_2lox-22: 0.21, Embryonic_stem_cells: 0.21
NB08_TTAGGACCAGGGAGAG-1 Neurons:adrenal_medulla_cell_line 0.23 684.31
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, Embryonic_stem_cells: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.32, iPS_cells:PDB_2lox-22: 0.32
NB08_CGGAGTCTCGGTCTAA-1 Neurons:adrenal_medulla_cell_line 0.19 674.99
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_2lox-22: 0.2, Embryonic_stem_cells: 0.2
NB08_CGGCTAGGTACGAAAT-1 Neurons:adrenal_medulla_cell_line 0.20 632.00
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.2
NB08_ACGTCAAGTACATCCA-1 Neurons:adrenal_medulla_cell_line 0.19 577.10
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_2lox-22: 0.17, Embryonic_stem_cells: 0.17
NB08_CGTCAGGCATCCAACA-1 Neurons:adrenal_medulla_cell_line 0.20 517.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_2lox-22: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.21
NB08_TTATGCTTCATTCACT-1 Neurons:adrenal_medulla_cell_line 0.20 451.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21
NB08_GCGCCAAAGGGTTTCT-1 Neurons:adrenal_medulla_cell_line 0.17 450.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_2lox-22: 0.17, Embryonic_stem_cells: 0.17
NB08_GACTAACCAGGCTCAC-1 Neurons:adrenal_medulla_cell_line 0.19 446.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:PDB_2lox-22: 0.19
NB08_GCGCCAACAAAGGTGC-1 Neurons:adrenal_medulla_cell_line 0.15 387.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:PDB_2lox-22: 0.12
NB08_GTGCTTCGTCCATCCT-1 Neurons:adrenal_medulla_cell_line 0.18 386.44
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, Embryonic_stem_cells: 0.18, iPS_cells:PDB_2lox-22: 0.17
NB13_TTAGGACTCATGCAAC-1 Neurons:adrenal_medulla_cell_line 0.11 351.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, Neurons:Schwann_cell: 0.21, B_cell:Memory: 0.21, T_cell:CD4+_central_memory: 0.2, Pro-B_cell_CD34+: 0.2, T_cell:CD4+: 0.2, T_cell:CD4+_Naive: 0.2
NB08_ATCCACCCACGTAAGG-1 Neurons:adrenal_medulla_cell_line 0.17 333.96
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, Embryonic_stem_cells: 0.15, iPS_cells:PDB_2lox-22: 0.15
NB08_GACGGCTAGATGCCTT-1 Neurons:adrenal_medulla_cell_line 0.17 333.10
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB08_GATCGATGTTATTCTC-1 Neurons:adrenal_medulla_cell_line 0.17 331.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB08_ACTGAACGTTTGTTTC-1 Neurons:adrenal_medulla_cell_line 0.18 325.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:PDB_2lox-22: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17
NB08_GATCGATTCACATACG-1 Neurons:adrenal_medulla_cell_line 0.18 313.45
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:skin_fibroblast-derived: 0.16
NB08_CGAGCCATCAGCGACC-1 Neurons:adrenal_medulla_cell_line 0.15 312.95
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_2lox-22: 0.16, Embryonic_stem_cells: 0.16
NB08_TCGTACCTCTTACCGC-1 Neurons:adrenal_medulla_cell_line 0.17 302.88
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_2lox-22: 0.13
NB08_TCTATTGTCTATCCCG-1 Neurons:adrenal_medulla_cell_line 0.16 292.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_2lox-22: 0.13
NB08_ATCATCTTCATGCATG-1 Neurons:adrenal_medulla_cell_line 0.14 288.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_2lox-22: 0.12
NB08_ACGATACTCGCCAGCA-1 Neurons:adrenal_medulla_cell_line 0.17 286.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, Embryonic_stem_cells: 0.15, iPS_cells:PDB_2lox-22: 0.14
NB08_TCAGGATCAAGCCCAC-1 Neurons:adrenal_medulla_cell_line 0.13 284.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.15, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_2lox-22: 0.13
NB08_TACTTGTTCGCCGTGA-1 Neurons:adrenal_medulla_cell_line 0.15 283.30
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, Embryonic_stem_cells: 0.15, iPS_cells:PDB_2lox-22: 0.15
NB08_ATAAGAGGTCCGAACC-1 Neurons:adrenal_medulla_cell_line 0.18 282.64
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_2lox-22: 0.15, Embryonic_stem_cells: 0.15
NB08_ACTGTCCGTATTCTCT-1 Neurons:adrenal_medulla_cell_line 0.17 281.06
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_2lox-22: 0.13
NB11_TTGTAGGCAGACAAGC-1 Neurons:adrenal_medulla_cell_line 0.23 281.00
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:skin_fibroblast-derived: 0.23
NB08_ACCCACTCAACTGCTA-1 Neurons:adrenal_medulla_cell_line 0.17 280.01
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_2lox-22: 0.18, Embryonic_stem_cells: 0.18
NB08_CACACAAAGCCACGCT-1 Neurons:adrenal_medulla_cell_line 0.14 276.31
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.13, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, iPS_cells:PDB_1lox-21Puro-26: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.11, iPS_cells:PDB_2lox-22: 0.11
NB13_GCACATACAAGCGATG-1 Neurons:adrenal_medulla_cell_line 0.18 275.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB08_CAAGTTGCAAGCTGGA-1 Neurons:adrenal_medulla_cell_line 0.15 275.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Embryonic_stem_cells: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_2lox-5: 0.14
NB08_TTTGGTTGTGGAAAGA-1 Neurons:adrenal_medulla_cell_line 0.15 273.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_2lox-22: 0.19, iPS_cells:PDB_2lox-21: 0.19
NB08_ACTATCTGTACCCAAT-1 Neurons:adrenal_medulla_cell_line 0.18 264.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB08_AGGGTGATCTAAGCCA-1 Neurons:adrenal_medulla_cell_line 0.15 262.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.18, iPS_cells:PDB_2lox-5: 0.17, iPS_cells:PDB_2lox-22: 0.17, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Embryonic_stem_cells: 0.17
NB08_TACGGTAAGGCAATTA-1 Neurons:adrenal_medulla_cell_line 0.15 261.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_2lox-21: 0.15, iPS_cells:PDB_2lox-22: 0.14
NB08_TGATTTCAGACAAAGG-1 Neurons:adrenal_medulla_cell_line 0.17 259.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, Embryonic_stem_cells: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_2lox-22: 0.17
NB08_GTAACGTCATTGCGGC-1 Neurons:adrenal_medulla_cell_line 0.15 255.41
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, Embryonic_stem_cells: 0.15, iPS_cells:PDB_2lox-21: 0.15
NB08_CTAGTGAAGCAGGCTA-1 Neurons:adrenal_medulla_cell_line 0.15 255.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.14, Neuroepithelial_cell:ESC-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, Embryonic_stem_cells: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.11, iPS_cells:PDB_1lox-21Puro-26: 0.11, iPS_cells:PDB_2lox-22: 0.1
NB08_TAGACCAGTTTAAGCC-1 Neurons:adrenal_medulla_cell_line 0.15 248.66
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, Embryonic_stem_cells: 0.15, iPS_cells:PDB_2lox-22: 0.15
NB08_TTTATGCAGAGCTTCT-1 Neurons:adrenal_medulla_cell_line 0.16 246.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.13
NB08_ACACCGGCAGCTGTTA-1 Neurons:adrenal_medulla_cell_line 0.14 245.07
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:PDB_2lox-22: 0.12
NB08_AGAGTGGCACATCTTT-1 Neurons:adrenal_medulla_cell_line 0.13 244.17
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.15, Neuroepithelial_cell:ESC-derived: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, Astrocyte:Embryonic_stem_cell-derived: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_2lox-22: 0.12
NB08_GTATTCTTCCCTCTTT-1 Neurons:adrenal_medulla_cell_line 0.14 244.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_2lox-22: 0.15, Embryonic_stem_cells: 0.15
NB09_AGATTGCCACACCGCA-1 Neurons:adrenal_medulla_cell_line 0.21 243.13
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_2lox-22: 0.22
NB08_ATCATGGAGCGGCTTC-1 Neurons:adrenal_medulla_cell_line 0.18 242.44
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_2lox-22: 0.19, Embryonic_stem_cells: 0.18
NB08_CATGGCGAGCGTCAAG-1 Neurons:adrenal_medulla_cell_line 0.15 239.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_2lox-22: 0.13, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.13
NB08_TTGCCGTCACCGATAT-1 Neurons:adrenal_medulla_cell_line 0.16 239.80
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.17, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_2lox-22: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_2lox-21: 0.16
NB08_CATCCACCACCAGGCT-1 Neurons:adrenal_medulla_cell_line 0.16 239.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_2lox-22: 0.14
NB08_CTTAACTCATGGTCAT-1 Neurons:adrenal_medulla_cell_line 0.13 238.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.13, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_2lox-22: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_2lox-5: 0.12


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.78e-03
Mean rank of genes in gene set: 1803.75
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CDK1 0.0012136 453 GTEx DepMap Descartes 0.06 156.97
UBE2C 0.0011509 506 GTEx DepMap Descartes 0.08 461.35
MKI67 0.0003202 2471 GTEx DepMap Descartes 0.04 13.64
TOP2A 0.0001120 3785 GTEx DepMap Descartes 0.14 103.05


Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.18e-02
Mean rank of genes in gene set: 2174.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NPM1 0.0021495 117 GTEx DepMap Descartes 0.30 897.16
MIF 0.0010163 624 GTEx DepMap Descartes 0.15 856.22
TPI1 0.0008419 853 GTEx DepMap Descartes 0.14 418.01
TK1 -0.0002046 7104 GTEx DepMap Descartes 0.01 27.91


Chromaffin cell development (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.98e-02
Mean rank of genes in gene set: 1003.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
HAND2 0.0008271 887 GTEx DepMap Descartes 0.38 593.78
GATA3 0.0007002 1120 GTEx DepMap Descartes 0.41 562.23




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.95e-11
Mean rank of genes in gene set: 4920.98
Median rank of genes in gene set: 3540
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ANK2 0.0082386 3 GTEx DepMap Descartes 2.11 721.71
GLCCI1 0.0061513 12 GTEx DepMap Descartes 1.03 1108.08
ALK 0.0057726 14 GTEx DepMap Descartes 1.48 1024.79
ICA1 0.0057180 16 GTEx DepMap Descartes 1.17 2100.25
BMPR1B 0.0047136 22 GTEx DepMap Descartes 1.28 1040.64
SYT1 0.0046443 23 GTEx DepMap Descartes 1.42 1481.92
KIF21A 0.0042356 25 GTEx DepMap Descartes 0.54 397.53
GNG4 0.0042212 26 GTEx DepMap Descartes 0.43 406.12
MAP2 0.0041866 27 GTEx DepMap Descartes 0.82 412.31
EYA1 0.0040750 29 GTEx DepMap Descartes 0.42 515.06
HS6ST2 0.0035773 35 GTEx DepMap Descartes 0.28 300.53
DACH1 0.0035339 37 GTEx DepMap Descartes 0.25 269.39
FAM163A 0.0031902 43 GTEx DepMap Descartes 0.43 632.27
EML6 0.0030917 47 GTEx DepMap Descartes 0.25 126.69
ADAM22 0.0030749 49 GTEx DepMap Descartes 0.33 177.07
GRIA2 0.0029767 52 GTEx DepMap Descartes 0.39 339.42
THSD7A 0.0029071 55 GTEx DepMap Descartes 0.66 299.12
KLHL13 0.0028803 59 GTEx DepMap Descartes 0.46 388.80
RNF150 0.0027723 63 GTEx DepMap Descartes 0.39 182.97
FOXO3 0.0027671 64 GTEx DepMap Descartes 0.44 294.26
RIMBP2 0.0025073 84 GTEx DepMap Descartes 0.42 280.59
TMEM108 0.0025028 85 GTEx DepMap Descartes 0.34 301.34
SV2C 0.0023164 98 GTEx DepMap Descartes 0.14 61.79
CKB 0.0022941 99 GTEx DepMap Descartes 0.27 1009.65
KLHL23 0.0022103 110 GTEx DepMap Descartes 0.22 264.45
SNAP91 0.0021953 112 GTEx DepMap Descartes 0.47 479.08
TTC8 0.0021382 119 GTEx DepMap Descartes 0.15 157.70
AGTPBP1 0.0019713 154 GTEx DepMap Descartes 0.22 234.93
ELAVL3 0.0019427 162 GTEx DepMap Descartes 0.20 181.08
GAL 0.0019200 167 GTEx DepMap Descartes 0.25 1609.58


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8257.45
Median rank of genes in gene set: 9651
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RBMS1 0.0039592 30 GTEx DepMap Descartes 0.53 629.40
ENAH 0.0032456 41 GTEx DepMap Descartes 0.52 201.15
PDE3A 0.0027546 65 GTEx DepMap Descartes 0.25 170.44
LAMB1 0.0025672 76 GTEx DepMap Descartes 0.18 146.36
ATP2B1 0.0021488 118 GTEx DepMap Descartes 0.20 148.15
ATP8B2 0.0019547 159 GTEx DepMap Descartes 0.12 92.23
NES 0.0018618 177 GTEx DepMap Descartes 0.10 98.39
GPC6 0.0016751 221 GTEx DepMap Descartes 0.51 346.07
EGR1 0.0016127 245 GTEx DepMap Descartes 0.11 202.87
VIM 0.0016004 252 GTEx DepMap Descartes 0.16 324.53
HOMER1 0.0014991 288 GTEx DepMap Descartes 0.06 58.86
APP 0.0014117 322 GTEx DepMap Descartes 0.35 418.85
TRIM5 0.0011973 467 GTEx DepMap Descartes 0.06 94.14
KDM5B 0.0011226 523 GTEx DepMap Descartes 0.16 74.64
RGL1 0.0009628 689 GTEx DepMap Descartes 0.08 72.14
EMILIN1 0.0009541 700 GTEx DepMap Descartes 0.04 50.02
PTPRK 0.0009080 756 GTEx DepMap Descartes 0.19 NA
SPCS3 0.0008993 769 GTEx DepMap Descartes 0.04 49.28
SLC38A2 0.0008697 820 GTEx DepMap Descartes 0.14 143.15
CKAP4 0.0007876 956 GTEx DepMap Descartes 0.06 94.25
KDELR2 0.0007773 972 GTEx DepMap Descartes 0.09 156.08
LIPA 0.0007619 994 GTEx DepMap Descartes 0.07 129.62
UGDH 0.0007426 1030 GTEx DepMap Descartes 0.04 70.47
SERPINE2 0.0007064 1102 GTEx DepMap Descartes 0.11 95.53
TMEFF2 0.0006996 1121 GTEx DepMap Descartes 0.09 117.36
DESI2 0.0006537 1253 GTEx DepMap Descartes 0.03 NA
COPA 0.0006273 1312 GTEx DepMap Descartes 0.13 97.87
UAP1 0.0006260 1319 GTEx DepMap Descartes 0.03 56.16
SCRG1 0.0006222 1329 GTEx DepMap Descartes 0.02 26.38
DUSP6 0.0006038 1380 GTEx DepMap Descartes 0.03 37.34


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.27e-01
Mean rank of genes in gene set: 7149.58
Median rank of genes in gene set: 8166
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MSMO1 0.0008284 883 GTEx DepMap Descartes 0.05 121.21
SLC16A9 0.0007333 1053 GTEx DepMap Descartes 0.05 53.99
HMGCR 0.0007305 1060 GTEx DepMap Descartes 0.06 62.46
GSTA4 0.0006606 1230 GTEx DepMap Descartes 0.08 218.77
SLC1A2 0.0006018 1385 GTEx DepMap Descartes 0.09 34.05
CYB5B 0.0005423 1540 GTEx DepMap Descartes 0.06 59.69
SCARB1 0.0004697 1791 GTEx DepMap Descartes 0.04 34.01
GRAMD1B 0.0003385 2388 GTEx DepMap Descartes 0.02 13.93
FDPS 0.0003194 2475 GTEx DepMap Descartes 0.10 199.40
HMGCS1 0.0002669 2772 GTEx DepMap Descartes 0.05 36.71
DHCR7 0.0002387 2922 GTEx DepMap Descartes 0.01 17.73
STAR 0.0000523 4236 GTEx DepMap Descartes 0.00 1.21
LDLR 0.0000373 4370 GTEx DepMap Descartes 0.02 14.01
POR -0.0000578 5275 GTEx DepMap Descartes 0.03 44.49
TM7SF2 -0.0000754 5481 GTEx DepMap Descartes 0.03 59.00
FDX1 -0.0001518 6472 GTEx DepMap Descartes 0.01 11.61
INHA -0.0002089 7150 GTEx DepMap Descartes 0.00 5.99
SCAP -0.0002600 7726 GTEx DepMap Descartes 0.06 49.60
PDE10A -0.0003410 8606 GTEx DepMap Descartes 0.15 76.69
DHCR24 -0.0003644 8797 GTEx DepMap Descartes 0.02 15.47
FREM2 -0.0003662 8814 GTEx DepMap Descartes 0.00 0.22
NPC1 -0.0004980 9816 GTEx DepMap Descartes 0.05 35.21
BAIAP2L1 -0.0005110 9915 GTEx DepMap Descartes 0.00 4.53
SH3BP5 -0.0005243 10016 GTEx DepMap Descartes 0.02 27.68
JAKMIP2 -0.0005814 10368 GTEx DepMap Descartes 0.12 53.00
FDXR -0.0007344 11029 GTEx DepMap Descartes 0.01 8.84
SH3PXD2B -0.0008649 11414 GTEx DepMap Descartes 0.02 9.47
SGCZ -0.0008961 11485 GTEx DepMap Descartes 0.08 34.46
ERN1 -0.0009793 11670 GTEx DepMap Descartes 0.01 1.65
PAPSS2 -0.0011065 11876 GTEx DepMap Descartes 0.01 3.76


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.29e-01
Mean rank of genes in gene set: 6460.51
Median rank of genes in gene set: 7018
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EYA4 0.0073514 5 GTEx DepMap Descartes 0.67 656.96
ALK 0.0057726 14 GTEx DepMap Descartes 1.48 1024.79
EYA1 0.0040750 29 GTEx DepMap Descartes 0.42 515.06
TMEM132C 0.0035149 38 GTEx DepMap Descartes 0.91 764.40
PTCHD1 0.0022380 105 GTEx DepMap Descartes 0.10 35.86
MLLT11 0.0021227 123 GTEx DepMap Descartes 0.28 641.71
SLC6A2 0.0021036 130 GTEx DepMap Descartes 0.13 197.63
GAL 0.0019200 167 GTEx DepMap Descartes 0.25 1609.58
ISL1 0.0015478 274 GTEx DepMap Descartes 0.29 582.61
EPHA6 0.0015345 278 GTEx DepMap Descartes 0.31 307.37
MAB21L2 0.0014130 321 GTEx DepMap Descartes 0.07 145.98
SYNPO2 0.0012628 415 GTEx DepMap Descartes 0.22 64.22
TUBA1A 0.0009734 670 GTEx DepMap Descartes 1.07 2897.07
BASP1 0.0009439 715 GTEx DepMap Descartes 0.27 720.94
TMEFF2 0.0006996 1121 GTEx DepMap Descartes 0.09 117.36
MAP1B 0.0004641 1809 GTEx DepMap Descartes 0.56 208.29
TUBB2B 0.0003066 2546 GTEx DepMap Descartes 0.51 1299.15
CNTFR 0.0002063 3108 GTEx DepMap Descartes 0.05 112.06
SLC44A5 0.0001947 3192 GTEx DepMap Descartes 0.17 152.46
REEP1 0.0001181 3742 GTEx DepMap Descartes 0.08 84.94
GREM1 -0.0001967 7018 GTEx DepMap Descartes 0.00 0.90
CNKSR2 -0.0002206 7289 GTEx DepMap Descartes 0.16 73.28
RGMB -0.0006613 10727 GTEx DepMap Descartes 0.08 79.46
RPH3A -0.0007216 10979 GTEx DepMap Descartes 0.01 2.43
TUBB2A -0.0009187 11549 GTEx DepMap Descartes 0.11 311.66
FAT3 -0.0014881 12196 GTEx DepMap Descartes 0.06 7.28
RBFOX1 -0.0016039 12236 GTEx DepMap Descartes 1.14 800.99
CCND1 -0.0016973 12273 GTEx DepMap Descartes 0.37 394.21
MAB21L1 -0.0016993 12276 GTEx DepMap Descartes 0.02 16.36
STMN2 -0.0018209 12322 GTEx DepMap Descartes 0.70 1562.92


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 7535.71
Median rank of genes in gene set: 8048
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHRM3 0.0038856 32 GTEx DepMap Descartes 0.49 254.37
PTPRB 0.0013182 372 GTEx DepMap Descartes 0.06 21.48
ID1 0.0004999 1662 GTEx DepMap Descartes 0.02 67.56
PODXL 0.0003607 2260 GTEx DepMap Descartes 0.02 16.15
TMEM88 0.0002798 2690 GTEx DepMap Descartes 0.02 130.96
RAMP2 0.0001468 3521 GTEx DepMap Descartes 0.03 139.24
SHE -0.0000976 5756 GTEx DepMap Descartes 0.00 1.16
BTNL9 -0.0001047 5837 GTEx DepMap Descartes 0.00 0.79
NPR1 -0.0001231 6080 GTEx DepMap Descartes 0.00 1.00
CRHBP -0.0001622 6596 GTEx DepMap Descartes 0.00 0.32
CLDN5 -0.0001641 6619 GTEx DepMap Descartes 0.01 10.76
MMRN2 -0.0001752 6744 GTEx DepMap Descartes 0.00 1.83
GALNT15 -0.0001971 7023 GTEx DepMap Descartes 0.00 NA
F8 -0.0002032 7092 GTEx DepMap Descartes 0.00 0.40
CYP26B1 -0.0002184 7257 GTEx DepMap Descartes 0.00 1.92
SHANK3 -0.0002299 7389 GTEx DepMap Descartes 0.01 4.08
HYAL2 -0.0002385 7495 GTEx DepMap Descartes 0.01 11.74
NOTCH4 -0.0002672 7823 GTEx DepMap Descartes 0.01 3.14
SLCO2A1 -0.0002851 8030 GTEx DepMap Descartes 0.01 2.50
CDH5 -0.0002885 8066 GTEx DepMap Descartes 0.00 1.38
TIE1 -0.0003084 8273 GTEx DepMap Descartes 0.00 1.82
KANK3 -0.0003209 8399 GTEx DepMap Descartes 0.00 1.81
RASIP1 -0.0003514 8699 GTEx DepMap Descartes 0.00 1.92
IRX3 -0.0003611 8771 GTEx DepMap Descartes 0.00 0.16
EHD3 -0.0003657 8809 GTEx DepMap Descartes 0.00 3.09
ESM1 -0.0003762 8893 GTEx DepMap Descartes 0.00 1.41
KDR -0.0003990 9108 GTEx DepMap Descartes 0.00 0.42
FLT4 -0.0004504 9487 GTEx DepMap Descartes 0.00 0.54
CEACAM1 -0.0004986 9818 GTEx DepMap Descartes 0.01 8.36
ARHGAP29 -0.0005032 9853 GTEx DepMap Descartes 0.04 15.48


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9632.52
Median rank of genes in gene set: 10810
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCOLCE 0.0025615 79 GTEx DepMap Descartes 0.21 627.66
PRICKLE1 0.0005756 1448 GTEx DepMap Descartes 0.12 78.83
GAS2 0.0001341 3617 GTEx DepMap Descartes 0.02 49.82
OGN 0.0001115 3791 GTEx DepMap Descartes 0.01 12.86
SCARA5 0.0000300 4430 GTEx DepMap Descartes 0.00 1.56
RSPO3 -0.0000717 5437 GTEx DepMap Descartes 0.00 NA
PAMR1 -0.0001042 5831 GTEx DepMap Descartes 0.01 12.52
PCDH18 -0.0001582 6543 GTEx DepMap Descartes 0.00 0.37
LAMC3 -0.0002460 7584 GTEx DepMap Descartes 0.00 1.20
LRRC17 -0.0002646 7783 GTEx DepMap Descartes 0.01 8.86
LOX -0.0002733 7882 GTEx DepMap Descartes 0.00 2.02
ABCC9 -0.0004073 9173 GTEx DepMap Descartes 0.00 0.88
ELN -0.0005319 10070 GTEx DepMap Descartes 0.03 18.96
ACTA2 -0.0005744 10330 GTEx DepMap Descartes 0.02 33.02
EDNRA -0.0005798 10359 GTEx DepMap Descartes 0.00 1.68
HHIP -0.0006083 10494 GTEx DepMap Descartes 0.02 6.32
DKK2 -0.0006117 10510 GTEx DepMap Descartes 0.01 3.71
ADAMTSL3 -0.0006373 10627 GTEx DepMap Descartes 0.01 2.17
PDGFRA -0.0006390 10631 GTEx DepMap Descartes 0.00 0.87
GLI2 -0.0006473 10668 GTEx DepMap Descartes 0.00 1.56
CD248 -0.0006776 10804 GTEx DepMap Descartes 0.00 0.34
IGFBP3 -0.0006777 10805 GTEx DepMap Descartes 0.01 2.92
ABCA6 -0.0006797 10815 GTEx DepMap Descartes 0.00 0.90
SFRP2 -0.0006820 10825 GTEx DepMap Descartes 0.00 3.06
COL27A1 -0.0007098 10940 GTEx DepMap Descartes 0.00 0.97
ADAMTS2 -0.0007321 11020 GTEx DepMap Descartes 0.02 10.60
C7 -0.0007453 11072 GTEx DepMap Descartes 0.00 0.90
ITGA11 -0.0007469 11079 GTEx DepMap Descartes 0.00 0.43
CCDC80 -0.0007834 11185 GTEx DepMap Descartes 0.01 0.90
DCN -0.0007866 11193 GTEx DepMap Descartes 0.01 1.81


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7984.26
Median rank of genes in gene set: 11162
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FGF14 0.0052653 19 GTEx DepMap Descartes 1.40 541.28
CCSER1 0.0047247 21 GTEx DepMap Descartes 0.78 NA
GALNTL6 0.0031455 44 GTEx DepMap Descartes 0.23 309.94
EML6 0.0030917 47 GTEx DepMap Descartes 0.25 126.69
SPOCK3 0.0030642 50 GTEx DepMap Descartes 0.15 295.93
CDH18 0.0024335 92 GTEx DepMap Descartes 0.17 193.27
ARC 0.0019250 166 GTEx DepMap Descartes 0.06 107.74
TIAM1 0.0017966 195 GTEx DepMap Descartes 0.27 158.07
UNC80 0.0005622 1491 GTEx DepMap Descartes 0.25 71.86
LAMA3 0.0004736 1776 GTEx DepMap Descartes 0.04 12.81
PENK 0.0002848 2663 GTEx DepMap Descartes 0.01 26.63
GCH1 0.0001713 3344 GTEx DepMap Descartes 0.09 131.65
GRM7 -0.0000138 4855 GTEx DepMap Descartes 0.08 72.84
DGKK -0.0000633 5337 GTEx DepMap Descartes 0.00 2.39
HTATSF1 -0.0004216 9278 GTEx DepMap Descartes 0.03 53.98
PCSK2 -0.0004496 9484 GTEx DepMap Descartes 0.06 50.66
SORCS3 -0.0005619 10259 GTEx DepMap Descartes 0.01 3.33
TBX20 -0.0007025 10915 GTEx DepMap Descartes 0.03 52.99
SLC24A2 -0.0007689 11146 GTEx DepMap Descartes 0.01 2.11
CHGB -0.0007813 11178 GTEx DepMap Descartes 0.34 604.76
CDH12 -0.0011297 11902 GTEx DepMap Descartes 0.03 16.42
CNTN3 -0.0011884 11970 GTEx DepMap Descartes 0.01 2.48
KCTD16 -0.0012082 11997 GTEx DepMap Descartes 0.27 49.87
KSR2 -0.0012379 12023 GTEx DepMap Descartes 0.07 11.76
PCSK1N -0.0012826 12062 GTEx DepMap Descartes 0.28 1104.78
NTNG1 -0.0014163 12164 GTEx DepMap Descartes 0.14 82.93
TENM1 -0.0015315 12212 GTEx DepMap Descartes 0.11 NA
C1QL1 -0.0016125 12241 GTEx DepMap Descartes 0.01 6.66
ST18 -0.0017902 12308 GTEx DepMap Descartes 0.00 2.00
SLC35F3 -0.0018097 12318 GTEx DepMap Descartes 0.03 14.78


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 7429.07
Median rank of genes in gene set: 7790
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TSPAN5 0.0012380 434 GTEx DepMap Descartes 0.23 240.04
GCLC 0.0009321 729 GTEx DepMap Descartes 0.06 72.34
RAPGEF2 0.0008698 819 GTEx DepMap Descartes 0.16 93.09
XPO7 0.0003879 2138 GTEx DepMap Descartes 0.07 63.80
TFR2 0.0002898 2630 GTEx DepMap Descartes 0.08 86.28
SPTB 0.0002758 2717 GTEx DepMap Descartes 0.03 8.86
ABCB10 0.0002746 2726 GTEx DepMap Descartes 0.03 35.02
SLC4A1 -0.0000245 4946 GTEx DepMap Descartes 0.00 0.04
SLC25A21 -0.0000986 5770 GTEx DepMap Descartes 0.00 1.79
ALAS2 -0.0001331 6207 GTEx DepMap Descartes 0.00 0.00
TRAK2 -0.0001501 6447 GTEx DepMap Descartes 0.03 17.59
CAT -0.0002314 7409 GTEx DepMap Descartes 0.02 24.74
CPOX -0.0002348 7450 GTEx DepMap Descartes 0.01 12.82
TMCC2 -0.0002360 7467 GTEx DepMap Descartes 0.01 5.44
SLC25A37 -0.0002652 7790 GTEx DepMap Descartes 0.02 19.66
FECH -0.0003156 8345 GTEx DepMap Descartes 0.01 8.10
RGS6 -0.0004026 9133 GTEx DepMap Descartes 0.00 1.74
SELENBP1 -0.0004282 9332 GTEx DepMap Descartes 0.00 0.71
RHD -0.0005357 10090 GTEx DepMap Descartes 0.01 3.16
ANK1 -0.0005754 10335 GTEx DepMap Descartes 0.05 19.23
GYPC -0.0006057 10480 GTEx DepMap Descartes 0.00 0.43
MARCH3 -0.0006504 10677 GTEx DepMap Descartes 0.03 NA
SPECC1 -0.0006541 10696 GTEx DepMap Descartes 0.01 1.05
DENND4A -0.0007226 10987 GTEx DepMap Descartes 0.14 57.98
BLVRB -0.0007903 11203 GTEx DepMap Descartes 0.00 7.09
MICAL2 -0.0008720 11430 GTEx DepMap Descartes 0.01 1.07
SNCA -0.0015166 12206 GTEx DepMap Descartes 0.02 11.99
EPB41 -0.0021762 12409 GTEx DepMap Descartes 0.08 32.04
SOX6 -0.0023922 12441 GTEx DepMap Descartes 0.10 26.49
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9610.32
Median rank of genes in gene set: 11185
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FMN1 0.0012133 454 GTEx DepMap Descartes 0.39 122.02
RGL1 0.0009628 689 GTEx DepMap Descartes 0.08 72.14
CD163L1 0.0008645 831 GTEx DepMap Descartes 0.07 79.39
RBPJ 0.0002709 2745 GTEx DepMap Descartes 0.15 114.20
IFNGR1 0.0001534 3472 GTEx DepMap Descartes 0.04 60.97
CTSC -0.0000666 5380 GTEx DepMap Descartes 0.02 9.83
CYBB -0.0002473 7600 GTEx DepMap Descartes 0.01 4.65
CST3 -0.0003053 8235 GTEx DepMap Descartes 0.06 77.00
FGL2 -0.0003214 8405 GTEx DepMap Descartes 0.00 1.04
MS4A4A -0.0003441 8638 GTEx DepMap Descartes 0.00 1.43
CTSS -0.0004528 9512 GTEx DepMap Descartes 0.02 12.99
HCK -0.0004791 9693 GTEx DepMap Descartes 0.00 4.43
CPVL -0.0004813 9708 GTEx DepMap Descartes 0.01 13.79
CD163 -0.0005241 10015 GTEx DepMap Descartes 0.00 1.22
CSF1R -0.0005737 10327 GTEx DepMap Descartes 0.00 2.41
FGD2 -0.0006676 10750 GTEx DepMap Descartes 0.00 0.86
ATP8B4 -0.0007237 10992 GTEx DepMap Descartes 0.01 2.57
WWP1 -0.0007453 11071 GTEx DepMap Descartes 0.04 26.41
SLC1A3 -0.0007791 11173 GTEx DepMap Descartes 0.00 2.49
ADAP2 -0.0007880 11197 GTEx DepMap Descartes 0.01 9.16
HRH1 -0.0008046 11236 GTEx DepMap Descartes 0.01 4.57
CD14 -0.0008259 11308 GTEx DepMap Descartes 0.01 8.65
MERTK -0.0008275 11312 GTEx DepMap Descartes 0.00 1.38
SLCO2B1 -0.0008440 11359 GTEx DepMap Descartes 0.01 2.03
AXL -0.0009253 11561 GTEx DepMap Descartes 0.00 1.67
TGFBI -0.0010603 11814 GTEx DepMap Descartes 0.01 3.87
LGMN -0.0010756 11828 GTEx DepMap Descartes 0.01 21.12
MSR1 -0.0011758 11953 GTEx DepMap Descartes 0.02 9.92
ABCA1 -0.0013019 12078 GTEx DepMap Descartes 0.01 2.84
PTPRE -0.0013047 12079 GTEx DepMap Descartes 0.02 4.59


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9386.34
Median rank of genes in gene set: 11030
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCKS 0.0030021 51 GTEx DepMap Descartes 0.41 557.52
LAMB1 0.0025672 76 GTEx DepMap Descartes 0.18 146.36
VIM 0.0016004 252 GTEx DepMap Descartes 0.16 324.53
KCTD12 0.0005274 1585 GTEx DepMap Descartes 0.02 17.62
SFRP1 0.0004797 1755 GTEx DepMap Descartes 0.04 39.28
ERBB4 0.0004535 1854 GTEx DepMap Descartes 0.57 236.27
FIGN -0.0000583 5283 GTEx DepMap Descartes 0.06 21.32
HMGA2 -0.0001244 6101 GTEx DepMap Descartes 0.00 0.92
GFRA3 -0.0002312 7408 GTEx DepMap Descartes 0.04 71.08
MPZ -0.0002529 7654 GTEx DepMap Descartes 0.00 4.30
MDGA2 -0.0002621 7752 GTEx DepMap Descartes 0.00 0.01
EDNRB -0.0003357 8556 GTEx DepMap Descartes 0.00 0.16
PLP1 -0.0003477 8667 GTEx DepMap Descartes 0.00 0.03
COL18A1 -0.0004287 9334 GTEx DepMap Descartes 0.06 30.63
ADAMTS5 -0.0004564 9533 GTEx DepMap Descartes 0.00 0.41
ERBB3 -0.0004572 9537 GTEx DepMap Descartes 0.00 1.15
OLFML2A -0.0004724 9651 GTEx DepMap Descartes 0.00 0.32
PTPRZ1 -0.0005115 9919 GTEx DepMap Descartes 0.00 0.37
LAMC1 -0.0005224 10000 GTEx DepMap Descartes 0.03 16.53
COL25A1 -0.0005914 10409 GTEx DepMap Descartes 0.01 2.67
DST -0.0006338 10613 GTEx DepMap Descartes 0.55 95.48
SLC35F1 -0.0007342 11028 GTEx DepMap Descartes 0.02 7.52
GRIK3 -0.0007353 11032 GTEx DepMap Descartes 0.01 0.90
PLCE1 -0.0007669 11139 GTEx DepMap Descartes 0.02 2.87
PAG1 -0.0009446 11610 GTEx DepMap Descartes 0.12 41.94
GAS7 -0.0010914 11849 GTEx DepMap Descartes 0.01 2.59
TRPM3 -0.0011146 11886 GTEx DepMap Descartes 0.04 5.77
LAMA4 -0.0011667 11947 GTEx DepMap Descartes 0.01 2.51
IL1RAPL2 -0.0011917 11973 GTEx DepMap Descartes 0.01 6.64
SOX5 -0.0012004 11988 GTEx DepMap Descartes 0.14 69.32


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8512.73
Median rank of genes in gene set: 9662
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PDE3A 0.0027546 65 GTEx DepMap Descartes 0.25 170.44
ACTB 0.0021114 129 GTEx DepMap Descartes 1.09 2610.70
HIPK2 0.0008932 778 GTEx DepMap Descartes 0.20 59.29
PRKAR2B 0.0005757 1447 GTEx DepMap Descartes 0.11 142.89
DOK6 0.0004717 1785 GTEx DepMap Descartes 0.09 39.52
TPM4 0.0004071 2056 GTEx DepMap Descartes 0.07 62.91
MED12L 0.0003868 2142 GTEx DepMap Descartes 0.05 21.55
ZYX 0.0001427 3551 GTEx DepMap Descartes 0.03 55.32
RAP1B 0.0000006 4702 GTEx DepMap Descartes 0.06 19.00
ITGB3 -0.0001499 6443 GTEx DepMap Descartes 0.00 0.00
MMRN1 -0.0001506 6455 GTEx DepMap Descartes 0.00 1.39
P2RX1 -0.0002186 7262 GTEx DepMap Descartes 0.00 0.80
FLNA -0.0002366 7472 GTEx DepMap Descartes 0.07 32.34
TUBB1 -0.0002482 7609 GTEx DepMap Descartes 0.00 0.03
ACTN1 -0.0002694 7843 GTEx DepMap Descartes 0.08 64.07
GP1BA -0.0003044 8228 GTEx DepMap Descartes 0.00 4.77
LIMS1 -0.0003263 8464 GTEx DepMap Descartes 0.06 53.61
TRPC6 -0.0003596 8761 GTEx DepMap Descartes 0.00 1.05
FERMT3 -0.0003948 9078 GTEx DepMap Descartes 0.00 3.57
SPN -0.0004156 9234 GTEx DepMap Descartes 0.00 1.43
TGFB1 -0.0004534 9515 GTEx DepMap Descartes 0.03 43.29
ANGPT1 -0.0004649 9594 GTEx DepMap Descartes 0.00 1.51
ARHGAP6 -0.0004747 9662 GTEx DepMap Descartes 0.00 1.83
MYLK -0.0004789 9690 GTEx DepMap Descartes 0.01 2.48
CD84 -0.0005144 9946 GTEx DepMap Descartes 0.00 1.09
PLEK -0.0005313 10065 GTEx DepMap Descartes 0.00 1.66
PSTPIP2 -0.0005323 10074 GTEx DepMap Descartes 0.00 3.56
TLN1 -0.0006720 10769 GTEx DepMap Descartes 0.02 6.57
STOM -0.0007011 10908 GTEx DepMap Descartes 0.01 10.39
VCL -0.0007039 10918 GTEx DepMap Descartes 0.03 13.90


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9254.33
Median rank of genes in gene set: 11469.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMSB10 0.0039046 31 GTEx DepMap Descartes 2.23 27186.09
BCL2 0.0025631 78 GTEx DepMap Descartes 0.68 412.79
TOX 0.0015591 270 GTEx DepMap Descartes 0.40 432.13
BACH2 0.0015515 272 GTEx DepMap Descartes 0.25 121.90
PDE3B 0.0013554 352 GTEx DepMap Descartes 0.14 102.48
FYN 0.0011127 531 GTEx DepMap Descartes 0.34 385.64
ANKRD44 0.0007898 952 GTEx DepMap Descartes 0.13 71.22
WIPF1 0.0006691 1198 GTEx DepMap Descartes 0.08 68.78
SCML4 0.0000462 4303 GTEx DepMap Descartes 0.06 50.60
EVL -0.0004023 9129 GTEx DepMap Descartes 0.28 285.35
CCL5 -0.0004507 9493 GTEx DepMap Descartes 0.00 7.02
CCND3 -0.0005537 10199 GTEx DepMap Descartes 0.03 39.43
ARHGDIB -0.0005551 10205 GTEx DepMap Descartes 0.00 5.68
SAMD3 -0.0006149 10523 GTEx DepMap Descartes 0.00 2.33
PLEKHA2 -0.0006875 10845 GTEx DepMap Descartes 0.01 5.55
LEF1 -0.0006920 10871 GTEx DepMap Descartes 0.00 2.28
STK39 -0.0007475 11085 GTEx DepMap Descartes 0.17 188.24
RCSD1 -0.0007884 11199 GTEx DepMap Descartes 0.01 1.62
LCP1 -0.0008024 11232 GTEx DepMap Descartes 0.01 4.42
ITPKB -0.0008566 11393 GTEx DepMap Descartes 0.00 1.39
SP100 -0.0008740 11436 GTEx DepMap Descartes 0.02 5.97
MBNL1 -0.0009013 11503 GTEx DepMap Descartes 0.13 69.84
MCTP2 -0.0009101 11528 GTEx DepMap Descartes 0.01 1.54
IKZF1 -0.0009154 11539 GTEx DepMap Descartes 0.00 1.41
SKAP1 -0.0009463 11615 GTEx DepMap Descartes 0.01 10.51
PRKCH -0.0009592 11637 GTEx DepMap Descartes 0.01 8.12
PTPRC -0.0009910 11688 GTEx DepMap Descartes 0.01 1.94
MSN -0.0010492 11800 GTEx DepMap Descartes 0.01 3.90
ETS1 -0.0010809 11833 GTEx DepMap Descartes 0.01 2.78
ABLIM1 -0.0013060 12081 GTEx DepMap Descartes 0.05 15.71


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.22e-02
Mean rank of genes in gene set: 24
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CUX2 0.0045374 24 GTEx DepMap Descartes 0.36 227.61


HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.41e-02
Mean rank of genes in gene set: 99
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CKB 0.0022941 99 GTEx DepMap Descartes 0.27 1009.65


Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.03e-01
Mean rank of genes in gene set: 3035.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GRIN1 0.0029014 56 GTEx DepMap Descartes 0.14 138.59
KL -0.0001176 6015 GTEx DepMap Descartes 0.00 0.59