Program: 6. Endothelial.

Program: 6. Endothelial.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program. Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret. The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program (currently only calculated for the cells in the first 50/50 split of the data). Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 VWF 0.0097392 von Willebrand factor GTEx DepMap Descartes 18.72 522.38
2 PLVAP 0.0087237 plasmalemma vesicle associated protein GTEx DepMap Descartes 10.76 1209.61
3 PTPRB 0.0084249 protein tyrosine phosphatase receptor type B GTEx DepMap Descartes 4.29 93.89
4 CALCRL 0.0078733 calcitonin receptor like receptor GTEx DepMap Descartes 6.08 252.96
5 FLT1 0.0076759 fms related receptor tyrosine kinase 1 GTEx DepMap Descartes 6.83 260.06
6 ESAM 0.0076363 endothelial cell adhesion molecule GTEx DepMap Descartes 5.10 576.43
7 SOX7 0.0076150 SRY-box transcription factor 7 GTEx DepMap Descartes 4.74 366.15
8 EMCN 0.0073581 endomucin GTEx DepMap Descartes 5.11 364.84
9 CDH5 0.0073036 cadherin 5 GTEx DepMap Descartes 2.43 158.99
10 GJA1 0.0071161 gap junction protein alpha 1 GTEx DepMap Descartes 6.50 560.96
11 SHANK3 0.0069569 SH3 and multiple ankyrin repeat domains 3 GTEx DepMap Descartes 3.27 117.92
12 SLCO2A1 0.0068811 solute carrier organic anion transporter family member 2A1 GTEx DepMap Descartes 3.31 235.54
13 KDR 0.0068613 kinase insert domain receptor GTEx DepMap Descartes 2.39 109.57
14 TM4SF1 0.0068401 transmembrane 4 L six family member 1 GTEx DepMap Descartes 37.66 3102.93
15 PODXL 0.0068278 podocalyxin like GTEx DepMap Descartes 3.13 148.94
16 MYCT1 0.0066585 MYC target 1 GTEx DepMap Descartes 2.21 195.51
17 F2RL3 0.0066568 F2R like thrombin or trypsin receptor 3 GTEx DepMap Descartes 2.35 165.78
18 TIE1 0.0066331 tyrosine kinase with immunoglobulin like and EGF like domains 1 GTEx DepMap Descartes 3.61 267.50
19 MMRN2 0.0065329 multimerin 2 GTEx DepMap Descartes 2.63 171.82
20 AQP1 0.0064667 aquaporin 1 (Colton blood group) GTEx DepMap Descartes 11.82 1126.85
21 ROBO4 0.0062728 roundabout guidance receptor 4 GTEx DepMap Descartes 1.63 96.99
22 INSR 0.0062537 insulin receptor GTEx DepMap Descartes 5.67 176.77
23 CYYR1 0.0060635 cysteine and tyrosine rich 1 GTEx DepMap Descartes 1.60 132.16
24 LMO2 0.0060305 LIM domain only 2 GTEx DepMap Descartes 2.49 328.70
25 ERG 0.0058984 ETS transcription factor ERG GTEx DepMap Descartes 3.16 NA
26 ESM1 0.0057679 endothelial cell specific molecule 1 GTEx DepMap Descartes 4.41 421.55
27 RAMP2 0.0056238 receptor activity modifying protein 2 GTEx DepMap Descartes 2.51 808.82
28 MPZL2 0.0055957 myelin protein zero like 2 GTEx DepMap Descartes 1.65 177.48
29 ENG 0.0055463 endoglin GTEx DepMap Descartes 8.04 774.81
30 PDLIM1 0.0055012 PDZ and LIM domain 1 GTEx DepMap Descartes 8.92 1733.93
31 GNG11 0.0054987 G protein subunit gamma 11 GTEx DepMap Descartes 3.33 322.47
32 FKBP1A 0.0054739 FKBP prolyl isomerase 1A GTEx DepMap Descartes 10.31 1722.36
33 HSPG2 0.0053606 heparan sulfate proteoglycan 2 GTEx DepMap Descartes 5.59 107.78
34 NCOA7 0.0053290 nuclear receptor coactivator 7 GTEx DepMap Descartes 6.86 NA
35 SWAP70 0.0053112 switching B cell complex subunit SWAP70 GTEx DepMap Descartes 4.12 219.10
36 PNP 0.0052575 purine nucleoside phosphorylase GTEx DepMap Descartes 8.11 757.90
37 STC1 0.0052196 stanniocalcin 1 GTEx DepMap Descartes 13.42 1059.30
38 CLEC14A 0.0051680 C-type lectin domain containing 14A GTEx DepMap Descartes 2.02 286.62
39 BCL6B 0.0050324 BCL6B transcription repressor GTEx DepMap Descartes 1.16 86.23
40 WWTR1 0.0050264 WW domain containing transcription regulator 1 GTEx DepMap Descartes 6.00 299.34
41 PTPRM 0.0050224 protein tyrosine phosphatase receptor type M GTEx DepMap Descartes 2.72 110.54
42 MECOM 0.0050002 MDS1 and EVI1 complex locus GTEx DepMap Descartes 1.11 61.83
43 TCF4 0.0049787 transcription factor 4 GTEx DepMap Descartes 12.37 417.13
44 GRB10 0.0049584 growth factor receptor bound protein 10 GTEx DepMap Descartes 2.90 137.59
45 ADAMTS9 0.0049208 ADAM metallopeptidase with thrombospondin type 1 motif 9 GTEx DepMap Descartes 6.97 248.00
46 RHOJ 0.0048439 ras homolog family member J GTEx DepMap Descartes 3.06 215.29
47 TEK 0.0048318 TEK receptor tyrosine kinase GTEx DepMap Descartes 1.00 56.73
48 FLT4 0.0047876 fms related receptor tyrosine kinase 4 GTEx DepMap Descartes 1.17 57.58
49 RAPGEF4 0.0047773 Rap guanine nucleotide exchange factor 4 GTEx DepMap Descartes 1.06 70.54
50 CAV1 0.0046754 caveolin 1 GTEx DepMap Descartes 9.80 757.19


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UMAP plots showing activity of gene expression program identified in community:6. Endothelial

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 6. Endothelial:
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
MURARO_PANCREAS_ENDOTHELIAL_CELL 4.63e-56 177.04 84.16 3.10e-53 3.10e-53
41VWF, PLVAP, PTPRB, CALCRL, FLT1, ESAM, EMCN, CDH5, SHANK3, SLCO2A1, KDR, TM4SF1, PODXL, MYCT1, F2RL3, TIE1, MMRN2, ROBO4, INSR, CYYR1, LMO2, ERG, ESM1, RAMP2, GNG11, FKBP1A, SWAP70, PNP, STC1, CLEC14A, BCL6B, WWTR1, MECOM, TCF4, GRB10, ADAMTS9, RHOJ, TEK, FLT4, RAPGEF4, CAV1
 362
AIZARANI_LIVER_C10_MVECS_1 1.80e-52 153.21 78.37 6.05e-50 1.21e-49
37VWF, PLVAP, PTPRB, CALCRL, FLT1, ESAM, SOX7, EMCN, CDH5, GJA1, SHANK3, SLCO2A1, KDR, TM4SF1, MYCT1, TIE1, MMRN2, AQP1, ROBO4, INSR, CYYR1, LMO2, ERG, RAMP2, ENG, PDLIM1, GNG11, FKBP1A, CLEC14A, WWTR1, PTPRM, TCF4, GRB10, ADAMTS9, RHOJ, TEK, CAV1
 269
AIZARANI_LIVER_C29_MVECS_2 6.05e-50 128.89 66.03 1.35e-47 4.06e-47
37VWF, PLVAP, PTPRB, CALCRL, FLT1, ESAM, SOX7, EMCN, CDH5, GJA1, SLCO2A1, TM4SF1, MYCT1, TIE1, MMRN2, AQP1, INSR, CYYR1, LMO2, ERG, RAMP2, ENG, PDLIM1, GNG11, FKBP1A, NCOA7, SWAP70, PNP, STC1, CLEC14A, WWTR1, MECOM, TCF4, ADAMTS9, RHOJ, TEK, CAV1
 313
CUI_DEVELOPING_HEART_C4_ENDOTHELIAL_CELL 3.55e-38 112.99 60.29 3.97e-36 2.38e-35
26VWF, PLVAP, PTPRB, CALCRL, FLT1, ESAM, SOX7, EMCN, CDH5, SLCO2A1, KDR, TM4SF1, PODXL, MYCT1, TIE1, MMRN2, ROBO4, CYYR1, RAMP2, ENG, GNG11, FKBP1A, CLEC14A, WWTR1, ADAMTS9, TEK
 146
GAO_LARGE_INTESTINE_24W_C2_MKI67POS_PROGENITOR 6.83e-33 107.59 56.52 6.55e-31 4.58e-30
22VWF, PLVAP, PTPRB, CALCRL, FLT1, ESAM, EMCN, CDH5, SLCO2A1, KDR, TM4SF1, PODXL, MYCT1, TIE1, MMRN2, ROBO4, CYYR1, ERG, RAMP2, ENG, GNG11, CLEC14A
 113
DESCARTES_FETAL_INTESTINE_VASCULAR_ENDOTHELIAL_CELLS 6.23e-18 109.85 46.47 1.99e-16 4.18e-15
11PLVAP, FLT1, ESAM, SOX7, EMCN, SLCO2A1, MMRN2, CYYR1, ESM1, HSPG2, CLEC14A
 43
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_PERICYTES 4.57e-24 92.82 45.56 1.80e-22 3.07e-21
16VWF, PLVAP, CALCRL, FLT1, ESAM, EMCN, TM4SF1, PODXL, AQP1, CYYR1, RAMP2, ENG, GNG11, CLEC14A, TCF4, CAV1
 79
DESCARTES_FETAL_EYE_VASCULAR_ENDOTHELIAL_CELLS 5.15e-25 87.77 43.91 2.16e-23 3.46e-22
17VWF, PLVAP, CALCRL, FLT1, SOX7, CDH5, SHANK3, PODXL, MYCT1, TIE1, ROBO4, ERG, RAMP2, ENG, CLEC14A, TEK, FLT4
 90
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_1 1.75e-42 79.63 41.50 2.93e-40 1.17e-39
36VWF, PTPRB, CALCRL, FLT1, ESAM, SOX7, EMCN, CDH5, GJA1, SLCO2A1, KDR, TM4SF1, PODXL, MYCT1, TIE1, MMRN2, ROBO4, INSR, CYYR1, LMO2, ERG, RAMP2, ENG, GNG11, FKBP1A, CLEC14A, BCL6B, WWTR1, PTPRM, MECOM, TCF4, RHOJ, TEK, FLT4, RAPGEF4, CAV1
 440
DESCARTES_FETAL_STOMACH_VASCULAR_ENDOTHELIAL_CELLS 1.90e-13 107.35 39.20 4.90e-12 1.27e-10
8PLVAP, FLT1, ESAM, SOX7, EMCN, CYYR1, CLEC14A, BCL6B
 30
RUBENSTEIN_SKELETAL_MUSCLE_ENDOTHELIAL_CELLS 3.98e-27 71.12 37.16 2.22e-25 2.67e-24
20VWF, PTPRB, FLT1, ESAM, EMCN, CDH5, TM4SF1, PODXL, MYCT1, MMRN2, AQP1, RAMP2, ENG, PDLIM1, GNG11, FKBP1A, HSPG2, CLEC14A, TCF4, CAV1
 137
DESCARTES_FETAL_ADRENAL_VASCULAR_ENDOTHELIAL_CELLS 3.63e-25 63.65 33.08 1.62e-23 2.44e-22
19PLVAP, PTPRB, CALCRL, SOX7, CDH5, SHANK3, SLCO2A1, KDR, PODXL, TIE1, MMRN2, ROBO4, ESM1, RAMP2, ENG, CLEC14A, BCL6B, TEK, FLT4
 139
MANNO_MIDBRAIN_NEUROTYPES_HENDO 2.48e-40 67.45 32.10 3.32e-38 1.66e-37
41VWF, PLVAP, PTPRB, CALCRL, FLT1, ESAM, SOX7, EMCN, CDH5, GJA1, SHANK3, SLCO2A1, KDR, TM4SF1, PODXL, MYCT1, TIE1, MMRN2, ROBO4, INSR, CYYR1, LMO2, ERG, ESM1, RAMP2, ENG, GNG11, FKBP1A, HSPG2, PNP, CLEC14A, BCL6B, WWTR1, PTPRM, MECOM, TCF4, RHOJ, TEK, FLT4, RAPGEF4, CAV1
 888
DESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS 7.36e-24 62.24 31.85 2.74e-22 4.94e-21
18VWF, PLVAP, PTPRB, CALCRL, FLT1, EMCN, SHANK3, KDR, PODXL, MYCT1, TIE1, ERG, WWTR1, MECOM, ADAMTS9, RHOJ, TEK, CAV1
 131
DESCARTES_FETAL_PANCREAS_VASCULAR_ENDOTHELIAL_CELLS 7.45e-16 66.35 29.02 2.27e-14 5.00e-13
11PLVAP, FLT1, ESAM, SOX7, F2RL3, MMRN2, CYYR1, ESM1, HSPG2, CLEC14A, BCL6B
 64
AIZARANI_LIVER_C9_LSECS_1 1.31e-29 48.72 26.52 1.10e-27 8.82e-27
26PTPRB, FLT1, ESAM, SOX7, CDH5, SHANK3, KDR, TM4SF1, MYCT1, TIE1, ROBO4, INSR, ERG, ENG, PDLIM1, GNG11, FKBP1A, NCOA7, STC1, CLEC14A, WWTR1, TCF4, GRB10, ADAMTS9, RHOJ, FLT4
 304
DESCARTES_FETAL_PLACENTA_VASCULAR_ENDOTHELIAL_CELLS 1.44e-18 55.14 26.51 4.83e-17 9.66e-16
14PLVAP, SOX7, CDH5, SHANK3, KDR, TIE1, ROBO4, CYYR1, ERG, RAMP2, CLEC14A, BCL6B, RHOJ, TEK
 102
AIZARANI_LIVER_C13_LSECS_2 1.03e-28 48.46 26.31 6.28e-27 6.91e-26
25PTPRB, CALCRL, FLT1, ESAM, EMCN, CDH5, SHANK3, SLCO2A1, KDR, TM4SF1, MYCT1, F2RL3, TIE1, MMRN2, ROBO4, INSR, ERG, RAMP2, ENG, PDLIM1, GNG11, CLEC14A, TCF4, TEK, FLT4
 283
FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL 3.50e-29 43.41 23.73 2.61e-27 2.35e-26
27VWF, PTPRB, FLT1, ESAM, EMCN, CDH5, SLCO2A1, KDR, TM4SF1, PODXL, MYCT1, TIE1, ROBO4, CYYR1, LMO2, ERG, RAMP2, ENG, GNG11, FKBP1A, CLEC14A, WWTR1, MECOM, RHOJ, TEK, RAPGEF4, CAV1
 365
AIZARANI_LIVER_C20_LSECS_3 1.29e-26 42.59 23.08 6.68e-25 8.68e-24
24PTPRB, FLT1, ESAM, SOX7, CDH5, SHANK3, KDR, TM4SF1, MYCT1, TIE1, ROBO4, INSR, ERG, ENG, PDLIM1, FKBP1A, NCOA7, PNP, STC1, WWTR1, TCF4, GRB10, ADAMTS9, RHOJ
 295

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_TGF_BETA_SIGNALING 1.26e-03 15.63 3.02 3.16e-02 6.32e-02
3ENG, FKBP1A, WWTR1
 54
HALLMARK_KRAS_SIGNALING_UP 1.08e-03 7.12 2.18 3.16e-02 5.40e-02
5PLVAP, MPZL2, ENG, GNG11, FLT4
 200
HALLMARK_ANGIOGENESIS 8.94e-03 15.30 1.73 1.49e-01 4.47e-01
2SLCO2A1, STC1
 36
HALLMARK_UV_RESPONSE_DN 1.90e-02 5.66 1.11 2.38e-01 9.50e-01
3GJA1, PTPRM, CAV1
 144
HALLMARK_IL2_STAT5_SIGNALING 1.83e-01 2.64 0.31 8.40e-01 1.00e+00
2SWAP70, PNP
 199
HALLMARK_HYPOXIA 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2STC1, CAV1
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2GJA1, PODXL
 200
HALLMARK_APICAL_JUNCTION 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2VWF, MPZL2
 200
HALLMARK_MTORC1_SIGNALING 1.85e-01 2.63 0.31 8.40e-01 1.00e+00
2PNP, STC1
 200
HALLMARK_PANCREAS_BETA_CELLS 1.47e-01 6.54 0.16 8.40e-01 1.00e+00
1LMO2
 40
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 1.77e-01 5.31 0.13 8.40e-01 1.00e+00
1PDLIM1
 49
HALLMARK_INTERFERON_ALPHA_RESPONSE 3.20e-01 2.66 0.07 1.00e+00 1.00e+00
1NCOA7
 97
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 1.00e+00 1.00e+00
1VWF
 138
HALLMARK_DNA_REPAIR 4.49e-01 1.71 0.04 1.00e+00 1.00e+00
1PNP
 150
HALLMARK_APOPTOSIS 4.72e-01 1.59 0.04 1.00e+00 1.00e+00
1CAV1
 161
HALLMARK_ESTROGEN_RESPONSE_LATE 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CAV1
 200
HALLMARK_MYOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1WWTR1
 200
HALLMARK_INTERFERON_GAMMA_RESPONSE 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1PNP
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1GJA1
 200
HALLMARK_INFLAMMATORY_RESPONSE 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CALCRL
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_ADHERENS_JUNCTION 2.99e-03 11.39 2.22 2.78e-01 5.57e-01
3PTPRB, INSR, PTPRM
 73
KEGG_FOCAL_ADHESION 1.06e-03 7.16 2.19 1.96e-01 1.96e-01
5VWF, FLT1, KDR, FLT4, CAV1
 199
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.07e-02 7.06 1.39 6.66e-01 1.00e+00
3ESAM, CDH5, RAPGEF4
 116
KEGG_CELL_ADHESION_MOLECULES_CAMS 1.54e-02 6.14 1.21 7.18e-01 1.00e+00
3ESAM, CDH5, PTPRM
 133
KEGG_ECM_RECEPTOR_INTERACTION 4.36e-02 6.35 0.74 1.00e+00 1.00e+00
2VWF, HSPG2
 84
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 8.44e-02 3.05 0.60 1.00e+00 1.00e+00
3FLT1, KDR, FLT4
 265
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 7.56e-02 4.61 0.54 1.00e+00 1.00e+00
2CALCRL, RAMP2
 115
KEGG_ENDOCYTOSIS 1.59e-01 2.91 0.34 1.00e+00 1.00e+00
2FLT1, KDR
 181
KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 8.77e-02 11.59 0.28 1.00e+00 1.00e+00
1AQP1
 23
KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM 9.13e-02 11.08 0.26 1.00e+00 1.00e+00
1PNP
 24
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.87e-01 1.93 0.23 1.00e+00 1.00e+00
2CALCRL, F2RL3
 272
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1INSR
 42
KEGG_TYPE_II_DIABETES_MELLITUS 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1INSR
 47
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 2.40e-01 3.75 0.09 1.00e+00 1.00e+00
1VWF
 69
KEGG_VIRAL_MYOCARDITIS 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1CAV1
 70
KEGG_CHRONIC_MYELOID_LEUKEMIA 2.52e-01 3.54 0.09 1.00e+00 1.00e+00
1MECOM
 73
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1GJA1
 74
KEGG_VEGF_SIGNALING_PATHWAY 2.61e-01 3.40 0.08 1.00e+00 1.00e+00
1KDR
 76
KEGG_GAP_JUNCTION 3.01e-01 2.87 0.07 1.00e+00 1.00e+00
1GJA1
 90
KEGG_PYRIMIDINE_METABOLISM 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1PNP
 98

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr6q22 8.01e-02 4.45 0.52 1.00e+00 1.00e+00
2GJA1, NCOA7
 119
chr3q25 1.20e-01 3.47 0.41 1.00e+00 1.00e+00
2TM4SF1, WWTR1
 152
chr11q24 1.61e-01 2.88 0.34 1.00e+00 1.00e+00
2ESAM, ROBO4
 183
chr10q23 1.71e-01 2.77 0.32 1.00e+00 1.00e+00
2MMRN2, PDLIM1
 190
chr19p13 7.66e-01 1.04 0.21 1.00e+00 1.00e+00
3PLVAP, F2RL3, INSR
 773
chr12q15 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1PTPRB
 55
chr4q24 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1EMCN
 56
chr7p12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1GRB10
 58
chr16q21 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1CDH5
 74
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1KDR
 79
chr5q11 2.87e-01 3.04 0.07 1.00e+00 1.00e+00
1ESM1
 85
chr7q32 3.01e-01 2.87 0.07 1.00e+00 1.00e+00
1PODXL
 90
chr14q21 3.04e-01 2.83 0.07 1.00e+00 1.00e+00
1CLEC14A
 91
chr2q32 3.49e-01 2.38 0.06 1.00e+00 1.00e+00
1CALCRL
 108
chr20p13 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1FKBP1A
 117
chr3q22 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1SLCO2A1
 117
chr21q21 3.77e-01 2.16 0.05 1.00e+00 1.00e+00
1CYYR1
 119
chr3p14 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1ADAMTS9
 122
chr14q23 3.89e-01 2.07 0.05 1.00e+00 1.00e+00
1RHOJ
 124
chr8p21 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1STC1
 128

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
STAT5A_03 6.50e-04 6.36 2.20 2.80e-01 7.37e-01
6FLT1, EMCN, TIE1, HSPG2, STC1, TCF4
 274
ETS2_B 7.40e-04 6.20 2.14 2.80e-01 8.39e-01
6ESAM, CDH5, MYCT1, ESM1, GNG11, CLEC14A
 281
SOX9_B1 2.29e-03 5.96 1.83 3.15e-01 1.00e+00
5MYCT1, ERG, HSPG2, STC1, TEK
 238
ELF1_Q6 2.78e-03 5.69 1.75 3.15e-01 1.00e+00
5CALCRL, CDH5, TIE1, ESM1, TEK
 249
STAT5B_01 3.07e-03 5.56 1.71 3.15e-01 1.00e+00
5ERG, PDLIM1, STC1, GRB10, ADAMTS9
 255
RYTTCCTG_ETS2_B 5.29e-04 3.59 1.70 2.80e-01 6.00e-01
12CALCRL, FLT1, ESAM, CDH5, MYCT1, ROBO4, ERG, RAMP2, GNG11, CLEC14A, GRB10, RHOJ
 1112
STAT_01 3.23e-03 5.49 1.69 3.15e-01 1.00e+00
5FLT1, EMCN, PDLIM1, GRB10, ADAMTS9
 258
STAT5A_01 3.28e-03 5.47 1.68 3.15e-01 1.00e+00
5FLT1, PDLIM1, STC1, GRB10, ADAMTS9
 259
CATTGTYY_SOX9_B1 2.83e-03 4.71 1.63 3.15e-01 1.00e+00
6VWF, MYCT1, ERG, GNG11, HSPG2, TCF4
 368
STAT4_01 3.79e-03 5.28 1.62 3.30e-01 1.00e+00
5FLT1, ERG, BCL6B, MECOM, RHOJ
 268
GATA1_05 4.81e-03 4.98 1.53 3.69e-01 1.00e+00
5MYCT1, LMO2, ERG, STC1, MECOM
 284
TATA_C 4.88e-03 4.96 1.53 3.69e-01 1.00e+00
5MYCT1, LMO2, STC1, MECOM, TCF4
 285
GATAAGR_GATA_C 5.94e-03 4.72 1.45 3.96e-01 1.00e+00
5MYCT1, LMO2, ERG, STC1, MECOM
 299
RSRFC4_Q2 1.02e-02 5.10 1.32 4.49e-01 1.00e+00
4ESAM, SLCO2A1, ERG, PDLIM1
 217
TGTTTGY_HNF3_Q6 6.35e-03 3.22 1.30 4.00e-01 1.00e+00
8ESAM, EMCN, SLCO2A1, MMRN2, ROBO4, ERG, MPZL2, TCF4
 748
TTCYNRGAA_STAT5B_01 1.01e-02 4.13 1.27 4.49e-01 1.00e+00
5FLT1, PDLIM1, STC1, GRB10, ADAMTS9
 341
NKX3A_01 1.38e-02 4.65 1.20 4.49e-01 1.00e+00
4EMCN, MYCT1, ERG, STC1
 238
BRN2_01 1.42e-02 4.61 1.19 4.49e-01 1.00e+00
4ERG, MECOM, TCF4, RHOJ
 240
RGAGGAARY_PU1_Q6 1.33e-02 3.35 1.16 4.49e-01 1.00e+00
6PLVAP, EMCN, TIE1, MMRN2, ESM1, RHOJ
 515
NFAT_Q6 1.60e-02 4.44 1.15 4.49e-01 1.00e+00
4ERG, HSPG2, TEK, FLT4
 249

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_2_SIGNALING_PATHWAY 1.54e-04 172.68 14.09 2.89e-02 1.00e+00
2KDR, CLEC14A
 5
GOBP_LYMPHANGIOGENESIS 3.88e-05 56.82 10.14 9.66e-03 2.90e-01
3TIE1, CLEC14A, FLT4
 17
GOBP_CALCITONIN_FAMILY_RECEPTOR_SIGNALING_PATHWAY 3.22e-04 103.49 9.64 4.92e-02 1.00e+00
2CALCRL, RAMP2
 7
GOBP_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS 9.37e-06 36.12 8.90 2.97e-03 7.01e-02
4CDH5, KDR, RAMP2, TEK
 34
GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_CYTOSKELETON_POLARITY 4.28e-04 86.37 8.33 5.97e-02 1.00e+00
2AQP1, PDLIM1
 8
GOBP_LYMPH_VESSEL_MORPHOGENESIS 7.49e-05 44.24 8.07 1.70e-02 5.60e-01
3TIE1, CLEC14A, FLT4
 21
GOBP_BLOOD_VESSEL_MORPHOGENESIS 1.28e-13 12.70 6.79 3.73e-10 9.59e-10
20PTPRB, CALCRL, FLT1, CDH5, KDR, TIE1, MMRN2, AQP1, ROBO4, ESM1, RAMP2, ENG, HSPG2, CLEC14A, PTPRM, ADAMTS9, RHOJ, TEK, FLT4, CAV1
 677
GOBP_SPROUTING_ANGIOGENESIS 3.40e-08 15.68 6.60 2.31e-05 2.54e-04
9KDR, MMRN2, ESM1, RAMP2, CLEC14A, ADAMTS9, RHOJ, TEK, FLT4
 184
GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CELL_DEVELOPMENT 6.85e-04 64.86 6.55 7.76e-02 1.00e+00
2RAMP2, ENG
 10
GOBP_LYMPH_VESSEL_DEVELOPMENT 1.44e-04 34.58 6.44 2.77e-02 1.00e+00
3TIE1, CLEC14A, FLT4
 26
GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 1.98e-06 18.92 6.43 7.42e-04 1.48e-02
6FLT1, KDR, MMRN2, CLEC14A, GRB10, FLT4
 96
GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS 4.42e-05 23.58 5.93 1.07e-02 3.31e-01
4CDH5, KDR, RAMP2, TEK
 50
GOBP_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_INTEGRIN 8.35e-04 57.69 5.91 9.32e-02 1.00e+00
2PODXL, SWAP70
 11
GOBP_VASCULATURE_DEVELOPMENT 1.77e-12 10.89 5.83 2.26e-09 1.33e-08
20PTPRB, CALCRL, FLT1, CDH5, KDR, TIE1, MMRN2, AQP1, ROBO4, ESM1, RAMP2, ENG, HSPG2, CLEC14A, PTPRM, ADAMTS9, RHOJ, TEK, FLT4, CAV1
 786
GOBP_ENDOTHELIUM_DEVELOPMENT 9.96e-07 15.65 5.83 4.38e-04 7.45e-03
7CDH5, GJA1, KDR, TIE1, ROBO4, ENG, STC1
 137
GOBP_VASCULOGENESIS 1.35e-05 19.00 5.73 3.88e-03 1.01e-01
5KDR, TIE1, RAMP2, ENG, CAV1
 78
GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT 3.58e-07 14.26 5.69 1.91e-04 2.68e-03
8FLT1, CDH5, KDR, TIE1, AQP1, RAMP2, ENG, TEK
 175
GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT 1.44e-13 10.35 5.67 3.73e-10 1.08e-09
24PTPRB, CALCRL, FLT1, CDH5, GJA1, KDR, TIE1, MMRN2, AQP1, ROBO4, INSR, ESM1, RAMP2, ENG, PDLIM1, FKBP1A, HSPG2, CLEC14A, PTPRM, ADAMTS9, RHOJ, TEK, FLT4, CAV1
 1140
GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS 1.50e-13 10.34 5.66 3.73e-10 1.12e-09
24PTPRB, CALCRL, FLT1, SOX7, CDH5, GJA1, KDR, PODXL, TIE1, MMRN2, AQP1, ROBO4, ESM1, RAMP2, ENG, FKBP1A, HSPG2, CLEC14A, PTPRM, ADAMTS9, RHOJ, TEK, FLT4, CAV1
 1142
GOBP_REGULATION_OF_VASCULATURE_DEVELOPMENT 4.77e-09 12.00 5.66 3.80e-06 3.57e-05
12FLT1, CDH5, KDR, TIE1, AQP1, RAMP2, ENG, HSPG2, PTPRM, ADAMTS9, RHOJ, TEK
 341

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_UP 9.73e-07 12.40 4.96 4.74e-03 4.74e-03
8ESAM, CDH5, KDR, TM4SF1, TIE1, GNG11, RHOJ, TEK
 200
GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_FETAL_UP 1.19e-05 10.54 3.95 2.89e-02 5.79e-02
7ESAM, AQP1, LMO2, RAMP2, SWAP70, PNP, GRB10
 200
GSE20715_0H_VS_48H_OZONE_LUNG_UP 1.24e-04 8.78 3.02 1.00e-01 6.03e-01
6PLVAP, SLCO2A1, TM4SF1, LMO2, GNG11, CLEC14A
 200
GSE19772_HCMV_INFL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP 1.24e-04 8.78 3.02 1.00e-01 6.03e-01
6FLT1, F2RL3, LMO2, RAMP2, WWTR1, GRB10
 200
GSE21670_STAT3_KO_VS_WT_CD4_TCELL_IL6_TREATED_DN 1.24e-04 8.78 3.02 1.00e-01 6.03e-01
6ESAM, PODXL, MYCT1, TIE1, GNG11, TEK
 200
GSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_DP_THYMOCYTES_DN 1.24e-04 8.78 3.02 1.00e-01 6.03e-01
6ESAM, CDH5, SLCO2A1, ERG, MECOM, TCF4
 200
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN 6.12e-04 8.12 2.49 2.92e-01 1.00e+00
5TM4SF1, CYYR1, GNG11, CLEC14A, ADAMTS9
 176
GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN 7.83e-04 7.67 2.35 2.92e-01 1.00e+00
5ERG, ENG, CLEC14A, ADAMTS9, RHOJ
 186
GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP 9.44e-04 7.35 2.25 2.92e-01 1.00e+00
5MYCT1, ROBO4, ERG, WWTR1, MECOM
 194
GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_30MIN_UP 1.01e-03 7.23 2.22 2.92e-01 1.00e+00
5CALCRL, MYCT1, ROBO4, CYYR1, PNP
 197
GSE21670_UNTREATED_VS_TGFB_TREATED_CD4_TCELL_DN 1.03e-03 7.19 2.20 2.92e-01 1.00e+00
5ESAM, SLCO2A1, MYCT1, F2RL3, TIE1
 198
GSE17721_CTRL_VS_CPG_8H_BMDC_DN 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5TM4SF1, INSR, ENG, TEK, CAV1
 200
GSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_24H_UP 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5GJA1, SLCO2A1, GNG11, SWAP70, GRB10
 200
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5AQP1, GNG11, SWAP70, ADAMTS9, RHOJ
 200
GSE7831_1H_VS_4H_INFLUENZA_STIM_PDC_UP 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5MYCT1, AQP1, MECOM, GRB10, TEK
 200
GSE19198_CTRL_VS_IL21_TREATED_TCELL_24H_DN 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5SLCO2A1, PODXL, LMO2, RAMP2, CAV1
 200
GSE21774_CD56_BRIGHT_VS_DIM_CD62L_POSITIVE_NK_CELL_UP 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5VWF, AQP1, INSR, MECOM, GRB10
 200
GSE39556_CD8A_DC_VS_NK_CELL_UP 1.08e-03 7.12 2.18 2.92e-01 1.00e+00
5LMO2, ERG, GNG11, GRB10, CAV1
 200
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_UP 5.90e-03 6.00 1.55 6.59e-01 1.00e+00
4ESAM, TM4SF1, CYYR1, PTPRM
 185
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP 6.12e-03 5.94 1.54 6.59e-01 1.00e+00
4MPZL2, WWTR1, RHOJ, FLT4
 187

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
SOX7 7 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
LMO2 24 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Protein binds to bHLH TFs, which then bind to DNA (PMID: 9707419). Both transfac motifs are suspect - the bHLH motif likely resulted from an indirect interaction.
ERG 25 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NCOA7 34 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-activator; included only because TF-cat documents this
BCL6B 39 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
WWTR1 40 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-activator that binds to TEADs (PMID: 19324877) and TBX5 (PMID: 16332960)
MECOM 42 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
TCF4 43 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RAPGEF4 49 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ETS2 57 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PLXNA2 63 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade.
FZD4 69 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HHEX 73 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
ELK3 76 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
EPAS1 81 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
LHX6 88 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TSC22D1 101 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None TSC22D1 appears to homo- and heterodimerize with other TFs to affect transcription (PMID: 10488076). In vitro, it has been shown to bind GC-rich DNA sequences (PMID: 9022669)
RAPGEF5 102 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PREX2 125 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SSH1 132 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
WK012-O7 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.17 980.37
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.53, Endothelial_cells:lymphatic: 0.53, Endothelial_cells:HUVEC:IL-1b: 0.52, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.52, Endothelial_cells:blood_vessel: 0.51, Endothelial_cells:HUVEC: 0.51, Endothelial_cells:HUVEC:VEGF: 0.51, Endothelial_cells:lymphatic:KSHV: 0.51, Endothelial_cells:HUVEC:B._anthracis_LT: 0.5, Endothelial_cells:HUVEC:PR8-infected: 0.5
WK012-F3 Endothelial_cells:blood_vessel 0.20 954.02
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.57, Endothelial_cells:lymphatic: 0.56, Endothelial_cells:blood_vessel: 0.55, Endothelial_cells:lymphatic:KSHV: 0.55, Endothelial_cells:HUVEC: 0.54, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.54, Endothelial_cells:HUVEC:VEGF: 0.53, Endothelial_cells:HUVEC:IL-1b: 0.53, Endothelial_cells:HUVEC:B._anthracis_LT: 0.53, Endothelial_cells:HUVEC:PR8-infected: 0.53
WK074-I19 Endothelial_cells:lymphatic 0.19 899.14
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.52, Endothelial_cells:lymphatic: 0.52, Endothelial_cells:blood_vessel: 0.48, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.48, Endothelial_cells:lymphatic:KSHV: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Endothelial_cells:HUVEC:VEGF: 0.47
WK073-J4 Endothelial_cells:lymphatic:TNFa_48h 0.19 878.11
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:lymphatic: 0.48, Endothelial_cells:HUVEC:IL-1b: 0.46, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.46, Endothelial_cells:blood_vessel: 0.46, Endothelial_cells:lymphatic:KSHV: 0.46, Endothelial_cells:HUVEC:PR8-infected: 0.45, Endothelial_cells:HUVEC:B._anthracis_LT: 0.45, Endothelial_cells:HUVEC: 0.45, Endothelial_cells:HUVEC:VEGF: 0.44
WK073-B15 Endothelial_cells:lymphatic:TNFa_48h 0.18 852.84
Raw ScoresEndothelial_cells:lymphatic: 0.47, Endothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:lymphatic:KSHV: 0.45, Endothelial_cells:HUVEC:IL-1b: 0.44, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.42, Endothelial_cells:HUVEC:VEGF: 0.42
WK073-N3 Endothelial_cells:lymphatic:TNFa_48h 0.19 851.02
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:lymphatic:KSHV: 0.47, Endothelial_cells:blood_vessel: 0.47, Endothelial_cells:HUVEC:IFNg: 0.46, Endothelial_cells:HUVEC:IL-1b: 0.46, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.46, Endothelial_cells:HUVEC: 0.45, Endothelial_cells:HUVEC:PR8-infected: 0.45, Endothelial_cells:HUVEC:B._anthracis_LT: 0.45
KK052-L11 Endothelial_cells:blood_vessel 0.19 844.40
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:lymphatic:KSHV: 0.49, Endothelial_cells:blood_vessel: 0.49, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.47, Endothelial_cells:HUVEC: 0.46, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC:PR8-infected: 0.45, Endothelial_cells:HUVEC:B._anthracis_LT: 0.45
WK012-N17 Endothelial_cells:lymphatic:TNFa_48h 0.21 808.77
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.52, Endothelial_cells:lymphatic: 0.52, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.51, Endothelial_cells:HUVEC:IL-1b: 0.51, Endothelial_cells:blood_vessel: 0.5, Endothelial_cells:HUVEC:VEGF: 0.5, Endothelial_cells:lymphatic:KSHV: 0.5, Endothelial_cells:HUVEC: 0.5, Endothelial_cells:HUVEC:B._anthracis_LT: 0.49, Endothelial_cells:HUVEC:PR8-infected: 0.49
WK012-F8 Endothelial_cells:blood_vessel 0.20 806.26
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.48, Endothelial_cells:lymphatic: 0.48, Endothelial_cells:blood_vessel: 0.47, Endothelial_cells:lymphatic:KSHV: 0.47, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.45, Endothelial_cells:HUVEC:VEGF: 0.44, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:HUVEC:B._anthracis_LT: 0.44, Endothelial_cells:HUVEC:PR8-infected: 0.43
WK014-H23 Endothelial_cells:lymphatic:TNFa_48h 0.22 722.51
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.53, Endothelial_cells:lymphatic: 0.53, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.5, Endothelial_cells:lymphatic:KSHV: 0.5, Endothelial_cells:blood_vessel: 0.5, Endothelial_cells:HUVEC:PR8-infected: 0.49, Endothelial_cells:HUVEC:IL-1b: 0.49, Endothelial_cells:HUVEC:VEGF: 0.49, Endothelial_cells:HUVEC: 0.49, Endothelial_cells:HUVEC:B._anthracis_LT: 0.49
WK036-F21 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.18 635.30
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.49, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:HUVEC:IL-1b: 0.49, Endothelial_cells:HUVEC:VEGF: 0.48, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:HUVEC:IFNg: 0.48, Endothelial_cells:blood_vessel: 0.47, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.47, Endothelial_cells:HUVEC:H5N1-infected: 0.47
WK012-G16 Endothelial_cells:lymphatic 0.19 615.83
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:lymphatic: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.46, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.46, Endothelial_cells:lymphatic:KSHV: 0.45, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:HUVEC:PR8-infected: 0.44, Endothelial_cells:HUVEC:B._anthracis_LT: 0.44
WK014-P4 Endothelial_cells:blood_vessel 0.19 606.18
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.51, Endothelial_cells:lymphatic: 0.51, Endothelial_cells:blood_vessel: 0.5, Endothelial_cells:lymphatic:KSHV: 0.49, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.49, Endothelial_cells:HUVEC: 0.49, Endothelial_cells:HUVEC:IL-1b: 0.49, Endothelial_cells:HUVEC:VEGF: 0.48, Endothelial_cells:HUVEC:B._anthracis_LT: 0.47, Endothelial_cells:HUVEC:PR8-infected: 0.47
WK012-N19 Endothelial_cells:blood_vessel 0.19 602.41
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:lymphatic:KSHV: 0.49, Endothelial_cells:blood_vessel: 0.48, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.48, Endothelial_cells:HUVEC:IL-1b: 0.47, Endothelial_cells:HUVEC:VEGF: 0.46, Endothelial_cells:HUVEC:B._anthracis_LT: 0.46, Endothelial_cells:HUVEC:PR8-infected: 0.45
WK014-K10 Endothelial_cells:blood_vessel 0.18 585.54
Raw ScoresEndothelial_cells:lymphatic: 0.48, Endothelial_cells:lymphatic:TNFa_48h: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.47, Endothelial_cells:blood_vessel: 0.47, Endothelial_cells:lymphatic:KSHV: 0.46, Endothelial_cells:HUVEC: 0.46, Endothelial_cells:HUVEC:IL-1b: 0.45, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC:PR8-infected: 0.45, Endothelial_cells:HUVEC:B._anthracis_LT: 0.44
WK014-N11 Endothelial_cells:lymphatic:KSHV 0.13 578.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.46, Endothelial_cells:HUVEC:IL-1b: 0.46, Endothelial_cells:lymphatic: 0.46, Endothelial_cells:lymphatic:KSHV: 0.45, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:HUVEC:VEGF: 0.44, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:HUVEC:PR8-infected: 0.44, Endothelial_cells:HUVEC:B._anthracis_LT: 0.44
WK074-L19 Endothelial_cells:lymphatic:TNFa_48h 0.17 571.99
Raw ScoresEndothelial_cells:lymphatic: 0.46, Endothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:lymphatic:KSHV: 0.44, Endothelial_cells:HUVEC:IL-1b: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.43, Endothelial_cells:HUVEC:IFNg: 0.43, Endothelial_cells:HUVEC: 0.43, Endothelial_cells:HUVEC:VEGF: 0.43, Endothelial_cells:HUVEC:B._anthracis_LT: 0.43
WK012-M15 Endothelial_cells:HUVEC:IFNg 0.13 536.22
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:HUVEC:IL-1b: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:HUVEC:IFNg: 0.4, Endothelial_cells:HUVEC: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4
WK056-P4 Endothelial_cells:blood_vessel 0.16 534.19
Raw ScoresEndothelial_cells:HUVEC:IL-1b: 0.46, Endothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:lymphatic:KSHV: 0.45, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:HUVEC:VEGF: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42
KK052-L17 Endothelial_cells:blood_vessel 0.19 532.18
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.52, Endothelial_cells:lymphatic: 0.52, Endothelial_cells:blood_vessel: 0.5, Endothelial_cells:HUVEC:VEGF: 0.5, Endothelial_cells:HUVEC:IL-1b: 0.5, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.5, Endothelial_cells:HUVEC: 0.5, Endothelial_cells:HUVEC:PR8-infected: 0.49, Endothelial_cells:HUVEC:B._anthracis_LT: 0.49, Endothelial_cells:lymphatic:KSHV: 0.49
WK014-M18 Endothelial_cells:lymphatic:TNFa_48h 0.19 524.25
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:lymphatic: 0.46, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.45, Endothelial_cells:HUVEC:IL-1b: 0.45, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:lymphatic:KSHV: 0.44, Endothelial_cells:HUVEC:VEGF: 0.44, Endothelial_cells:HUVEC:B._anthracis_LT: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:IFNg: 0.43
WK096-D20 Endothelial_cells:blood_vessel 0.19 517.37
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.5, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:blood_vessel: 0.48, Endothelial_cells:lymphatic:KSHV: 0.47, Endothelial_cells:HUVEC:PR8-infected: 0.47, Endothelial_cells:HUVEC:B._anthracis_LT: 0.47, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.46, Endothelial_cells:HUVEC:H5N1-infected: 0.46, Endothelial_cells:HUVEC: 0.45
WK012-C20 Endothelial_cells:lymphatic:TNFa_48h 0.19 505.94
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC:VEGF: 0.43, Endothelial_cells:HUVEC:IL-1b: 0.43, Endothelial_cells:HUVEC: 0.43, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:blood_vessel: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42
WK073-F2 Endothelial_cells:lymphatic 0.17 487.36
Raw ScoresEndothelial_cells:lymphatic: 0.4, Endothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:lymphatic:KSHV: 0.39, Endothelial_cells:HUVEC:IL-1b: 0.37, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.37, Endothelial_cells:HUVEC: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC:VEGF: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.36
WK012-L16 Endothelial_cells:lymphatic:TNFa_48h 0.17 483.81
Raw ScoresEndothelial_cells:lymphatic: 0.43, Endothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:HUVEC:IL-1b: 0.42, Endothelial_cells:HUVEC:VEGF: 0.41, Endothelial_cells:HUVEC: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:IFNg: 0.4
WK056-P16 Endothelial_cells:blood_vessel 0.15 481.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.45, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:lymphatic:KSHV: 0.44, Endothelial_cells:HUVEC:IL-1b: 0.44, Endothelial_cells:HUVEC: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.43, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42, Endothelial_cells:HUVEC:H5N1-infected: 0.42
WMK002-L17 Endothelial_cells:HUVEC:IFNg 0.14 465.73
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:HUVEC:IL-1b: 0.45, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:HUVEC:PR8-infected: 0.45, Endothelial_cells:lymphatic:KSHV: 0.45, Endothelial_cells:HUVEC:IFNg: 0.44, Endothelial_cells:HUVEC:B._anthracis_LT: 0.44, Endothelial_cells:HUVEC:H5N1-infected: 0.44
KK053-L11 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.19 457.11
Raw ScoresEndothelial_cells:lymphatic: 0.47, Endothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:HUVEC:IFNg: 0.46, Endothelial_cells:HUVEC: 0.45, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.45, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC:H5N1-infected: 0.44, Endothelial_cells:HUVEC:PR8-infected: 0.44
KK059-O14 Endothelial_cells:lymphatic:TNFa_48h 0.23 444.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.5, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:IFNg: 0.43, Endothelial_cells:HUVEC:H5N1-infected: 0.43, Endothelial_cells:HUVEC:IL-1b: 0.43, Endothelial_cells:HUVEC:B._anthracis_LT: 0.43
WK012-M16 Endothelial_cells:lymphatic 0.22 434.75
Raw ScoresEndothelial_cells:lymphatic: 0.52, Endothelial_cells:lymphatic:TNFa_48h: 0.51, Endothelial_cells:blood_vessel: 0.5, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.5, Endothelial_cells:lymphatic:KSHV: 0.49, Endothelial_cells:HUVEC:IL-1b: 0.49, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:HUVEC:VEGF: 0.48, Endothelial_cells:HUVEC:B._anthracis_LT: 0.47, Endothelial_cells:HUVEC:PR8-infected: 0.46
WK056-P21 Endothelial_cells:lymphatic:TNFa_48h 0.16 433.87
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.45, Endothelial_cells:lymphatic: 0.44, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:HUVEC:IL-1b: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:HUVEC:H5N1-infected: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42, Endothelial_cells:HUVEC: 0.42
WK100-A16 Endothelial_cells:blood_vessel 0.17 430.36
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:lymphatic:KSHV: 0.44, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:IL-1b: 0.42, Endothelial_cells:HUVEC:IFNg: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42, Endothelial_cells:HUVEC: 0.42
WK036-J2 Endothelial_cells:blood_vessel 0.18 404.12
Raw ScoresEndothelial_cells:lymphatic: 0.49, Endothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:blood_vessel: 0.49, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:lymphatic:KSHV: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.48, Endothelial_cells:HUVEC:IFNg: 0.47, Endothelial_cells:HUVEC:PR8-infected: 0.47, Endothelial_cells:HUVEC:VEGF: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.47
TM37-F22 Endothelial_cells:blood_vessel 0.16 393.83
Raw ScoresEndothelial_cells:lymphatic: 0.44, Endothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC:IL-1b: 0.44, Endothelial_cells:blood_vessel: 0.43, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.42
WK014-M7 Endothelial_cells:blood_vessel 0.17 391.38
Raw ScoresEndothelial_cells:lymphatic:KSHV: 0.45, Endothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:lymphatic: 0.44, Endothelial_cells:HUVEC:IL-1b: 0.44, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.43, Endothelial_cells:HUVEC: 0.43, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42
WK012-C21 Tissue_stem_cells:BM_MSC:BMP2 0.15 382.81
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:lymphatic: 0.46, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.45, Endothelial_cells:HUVEC: 0.45, Tissue_stem_cells:BM_MSC:TGFb3: 0.45, Endothelial_cells:HUVEC:PR8-infected: 0.45, Endothelial_cells:blood_vessel: 0.45, Endothelial_cells:HUVEC:IL-1b: 0.45, Smooth_muscle_cells:vascular:IL-17: 0.45, Tissue_stem_cells:BM_MSC:BMP2: 0.45
WK056-N8 Endothelial_cells:HUVEC:IFNg 0.13 367.34
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:blood_vessel: 0.43, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:HUVEC:IL-1b: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.43, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.42, Endothelial_cells:HUVEC: 0.42
KK052-K20 Endothelial_cells:lymphatic:TNFa_48h 0.17 358.67
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:HUVEC:IL-1b: 0.44, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:H5N1-infected: 0.42, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:VEGF: 0.42
WK072-F19 Endothelial_cells:lymphatic 0.15 350.11
Raw ScoresEndothelial_cells:lymphatic: 0.41, Endothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:lymphatic:KSHV: 0.38, Endothelial_cells:HUVEC: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Endothelial_cells:HUVEC:VEGF: 0.38, Endothelial_cells:HUVEC:IL-1b: 0.38, Endothelial_cells:HUVEC:PR8-infected: 0.37
WK032-L20 Endothelial_cells:blood_vessel 0.16 348.96
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:HUVEC:IL-1b: 0.42, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4, Endothelial_cells:HUVEC: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.39
WK012-O14 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.15 348.25
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.39, Endothelial_cells:HUVEC:IFNg: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:lymphatic: 0.38, Endothelial_cells:HUVEC:IL-1b: 0.38, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.38, Endothelial_cells:HUVEC:VEGF: 0.37, Endothelial_cells:HUVEC: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:blood_vessel: 0.37
WK014-K11 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.15 339.40
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:HUVEC:IL-1b: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:IFNg: 0.4, Endothelial_cells:HUVEC: 0.39, Endothelial_cells:lymphatic: 0.39, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.39, Endothelial_cells:HUVEC:PR8-infected: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39
WK073-B1 Endothelial_cells:blood_vessel 0.15 335.98
Raw ScoresEndothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:HUVEC: 0.4, Tissue_stem_cells:BM_MSC:TGFb3: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC:VEGF: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39, Endothelial_cells:HUVEC:IL-1b: 0.39
WK012-G14 Endothelial_cells:blood_vessel 0.18 334.15
Raw ScoresEndothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC: 0.38, Endothelial_cells:HUVEC:IL-1b: 0.38, Endothelial_cells:HUVEC:VEGF: 0.37, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC:H5N1-infected: 0.36
KK002-C8 Endothelial_cells:lymphatic:TNFa_48h 0.18 333.06
Raw ScoresEndothelial_cells:lymphatic: 0.39, Endothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:lymphatic:KSHV: 0.37, Endothelial_cells:blood_vessel: 0.37, Endothelial_cells:HUVEC:VEGF: 0.36, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.36, Endothelial_cells:HUVEC: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.35, Endothelial_cells:HUVEC:IL-1b: 0.35, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34
WK014-F16 Endothelial_cells:lymphatic:KSHV 0.18 331.37
Raw ScoresEndothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:lymphatic: 0.39, Endothelial_cells:lymphatic:TNFa_48h: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC:IL-1b: 0.38, Endothelial_cells:HUVEC: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:VEGF: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.36
KK054-L4 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.16 329.33
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC:IL-1b: 0.45, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:HUVEC:IFNg: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:HUVEC:H5N1-infected: 0.43, Endothelial_cells:HUVEC:B._anthracis_LT: 0.43
WK014-B22 Endothelial_cells:lymphatic:TNFa_48h 0.20 321.64
Raw ScoresEndothelial_cells:lymphatic: 0.44, Endothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:HUVEC:IFNg: 0.42, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:IL-1b: 0.41, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.41
WK074-B22 Endothelial_cells:blood_vessel 0.15 316.85
Raw ScoresEndothelial_cells:lymphatic: 0.4, Endothelial_cells:lymphatic:TNFa_48h: 0.39, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:lymphatic:KSHV: 0.39, Endothelial_cells:HUVEC: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Endothelial_cells:HUVEC:IL-1b: 0.38, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC:VEGF: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37
KK054-C20 Endothelial_cells:lymphatic:TNFa_48h 0.20 316.78
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:lymphatic: 0.47, Endothelial_cells:HUVEC:VEGF: 0.45, Endothelial_cells:HUVEC:IL-1b: 0.45, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.44, Endothelial_cells:HUVEC: 0.44, Endothelial_cells:blood_vessel: 0.44, Endothelial_cells:HUVEC:B._anthracis_LT: 0.43, Endothelial_cells:HUVEC:PR8-infected: 0.43, Endothelial_cells:lymphatic:KSHV: 0.43


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.51e-06
Mean rank of genes in gene set: 2681.8
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GJA1 0.0071161 10 GTEx DepMap Descartes 6.50 560.96
TM4SF1 0.0068401 14 GTEx DepMap Descartes 37.66 3102.93
MECOM 0.0050002 42 GTEx DepMap Descartes 1.11 61.83
SPRY1 0.0041150 75 GTEx DepMap Descartes 5.79 759.86
DUSP6 0.0037409 90 GTEx DepMap Descartes 7.29 508.07
THBD 0.0032337 124 GTEx DepMap Descartes 6.24 401.84
MCF2L 0.0026453 172 GTEx DepMap Descartes 0.91 46.13
IGFBP3 0.0018636 285 GTEx DepMap Descartes 3.67 390.62
SHROOM2 0.0018070 297 GTEx DepMap Descartes 0.29 7.97
HES1 0.0017459 304 GTEx DepMap Descartes 6.21 1193.44
CLIC4 0.0015482 352 GTEx DepMap Descartes 3.24 202.25
RHOB 0.0012649 463 GTEx DepMap Descartes 4.07 438.63
JAG1 0.0011504 518 GTEx DepMap Descartes 1.36 58.04
IVNS1ABP 0.0009138 653 GTEx DepMap Descartes 2.53 182.11
MARCKSL1 0.0006309 906 GTEx DepMap Descartes 2.07 340.33
CDK1 -0.0001649 8428 GTEx DepMap Descartes 0.12 27.17
FBLN2 -0.0001892 8966 GTEx DepMap Descartes 1.37 81.20
ADAMTS1 -0.0002320 9756 GTEx DepMap Descartes 4.43 211.71
LFNG -0.0002567 10143 GTEx DepMap Descartes 0.07 7.27
FAM102A -0.0005398 12038 GTEx DepMap Descartes 0.25 15.28


Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.91e-04
Mean rank of genes in gene set: 45.75
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FLT1 0.0076759 5 GTEx DepMap Descartes 6.83 260.06
KDR 0.0068613 13 GTEx DepMap Descartes 2.39 109.57
PRCP 0.0046127 54 GTEx DepMap Descartes 4.00 148.05
EGFL7 0.0035057 111 GTEx DepMap Descartes 1.97 313.72


Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.36e-03
Mean rank of genes in gene set: 6
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PLVAP 0.0087237 2 GTEx DepMap Descartes 10.76 1209.61
PTPRB 0.0084249 3 GTEx DepMap Descartes 4.29 93.89
KDR 0.0068613 13 GTEx DepMap Descartes 2.39 109.57




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8590.87
Median rank of genes in gene set: 10430
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NCOA7 0.0053290 34 GTEx DepMap Descartes 6.86 NA
GRB10 0.0049584 44 GTEx DepMap Descartes 2.90 137.59
RPS6KA2 0.0037222 92 GTEx DepMap Descartes 1.43 70.57
CDC42EP3 0.0031216 134 GTEx DepMap Descartes 4.50 232.18
CD200 0.0030173 140 GTEx DepMap Descartes 2.15 261.04
TSPAN7 0.0026409 173 GTEx DepMap Descartes 1.60 223.29
TSPAN13 0.0024629 194 GTEx DepMap Descartes 1.15 159.52
MYRIP 0.0023277 206 GTEx DepMap Descartes 0.40 19.65
THSD7A 0.0018577 286 GTEx DepMap Descartes 1.32 35.28
KLF7 0.0018546 287 GTEx DepMap Descartes 1.33 39.74
ST3GAL6 0.0013133 444 GTEx DepMap Descartes 0.73 46.16
OLFM1 0.0011087 540 GTEx DepMap Descartes 0.73 83.38
RALGDS 0.0010853 555 GTEx DepMap Descartes 1.49 64.72
HEY1 0.0009913 601 GTEx DepMap Descartes 0.70 39.51
SLC35G2 0.0009696 612 GTEx DepMap Descartes 0.33 NA
GATA2 0.0009193 645 GTEx DepMap Descartes 1.29 98.90
GNB1 0.0008923 669 GTEx DepMap Descartes 3.32 291.72
AKAP12 0.0008870 676 GTEx DepMap Descartes 3.86 102.27
NET1 0.0008517 703 GTEx DepMap Descartes 1.30 82.98
SETD7 0.0008337 717 GTEx DepMap Descartes 0.96 27.17
DACH1 0.0007507 781 GTEx DepMap Descartes 0.24 11.17
RUNDC3B 0.0007210 804 GTEx DepMap Descartes 0.32 26.60
DPYSL2 0.0007127 811 GTEx DepMap Descartes 2.25 108.89
AP1S2 0.0006809 850 GTEx DepMap Descartes 1.27 96.20
TBC1D30 0.0006605 872 GTEx DepMap Descartes 0.15 4.48
INO80C 0.0006370 901 GTEx DepMap Descartes 0.33 25.45
ASRGL1 0.0005026 1101 GTEx DepMap Descartes 0.28 27.44
ARL6IP1 0.0004933 1118 GTEx DepMap Descartes 2.86 316.41
ARHGEF7 0.0004526 1195 GTEx DepMap Descartes 1.24 53.42
FAM155A 0.0003825 1359 GTEx DepMap Descartes 0.36 8.58


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.87e-02
Mean rank of genes in gene set: 5919.71
Median rank of genes in gene set: 4681
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GJA1 0.0071161 10 GTEx DepMap Descartes 6.50 560.96
TM4SF1 0.0068401 14 GTEx DepMap Descartes 37.66 3102.93
PDLIM1 0.0055012 30 GTEx DepMap Descartes 8.92 1733.93
WWTR1 0.0050264 40 GTEx DepMap Descartes 6.00 299.34
RHOJ 0.0048439 46 GTEx DepMap Descartes 3.06 215.29
PRCP 0.0046127 54 GTEx DepMap Descartes 4.00 148.05
SASH1 0.0043719 62 GTEx DepMap Descartes 5.89 195.20
SPARCL1 0.0043136 67 GTEx DepMap Descartes 13.61 1140.65
SPRY1 0.0041150 75 GTEx DepMap Descartes 5.79 759.86
ELK3 0.0040846 76 GTEx DepMap Descartes 3.12 189.72
APP 0.0038628 84 GTEx DepMap Descartes 8.17 634.62
DUSP6 0.0037409 90 GTEx DepMap Descartes 7.29 508.07
TGFBR2 0.0036782 99 GTEx DepMap Descartes 5.57 252.42
A2M 0.0036155 104 GTEx DepMap Descartes 11.60 699.42
SEMA3F 0.0036067 105 GTEx DepMap Descartes 0.78 72.53
SPRY4 0.0035970 106 GTEx DepMap Descartes 4.08 167.94
SEC14L1 0.0031735 128 GTEx DepMap Descartes 3.73 185.10
NRP1 0.0028508 153 GTEx DepMap Descartes 3.74 188.11
DLC1 0.0027910 157 GTEx DepMap Descartes 5.39 187.49
ARL4A 0.0025362 186 GTEx DepMap Descartes 1.71 124.22
COL4A1 0.0023938 202 GTEx DepMap Descartes 10.26 382.34
SHC1 0.0023754 203 GTEx DepMap Descartes 2.69 203.77
IL6ST 0.0023384 205 GTEx DepMap Descartes 8.21 224.37
SDCBP 0.0022447 219 GTEx DepMap Descartes 7.54 540.26
PTPRG 0.0021540 235 GTEx DepMap Descartes 1.49 41.86
PLS3 0.0021535 236 GTEx DepMap Descartes 1.90 140.82
LUZP1 0.0021061 242 GTEx DepMap Descartes 2.52 64.76
ID1 0.0021036 244 GTEx DepMap Descartes 3.18 701.28
LIFR 0.0020741 253 GTEx DepMap Descartes 1.86 46.38
ITM2B 0.0019426 275 GTEx DepMap Descartes 17.69 450.89


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.44e-01
Mean rank of genes in gene set: 7234.22
Median rank of genes in gene set: 8151.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SH3BP5 0.0027798 160 GTEx DepMap Descartes 2.71 217.72
CLU 0.0013013 450 GTEx DepMap Descartes 6.78 591.09
PDE10A 0.0010308 572 GTEx DepMap Descartes 0.34 9.64
BAIAP2L1 0.0009057 660 GTEx DepMap Descartes 0.12 9.76
SCARB1 0.0008766 688 GTEx DepMap Descartes 0.49 28.89
FDPS 0.0003757 1377 GTEx DepMap Descartes 0.76 109.62
LDLR 0.0003211 1535 GTEx DepMap Descartes 1.70 91.21
CYB5B 0.0001315 2523 GTEx DepMap Descartes 0.61 36.30
FDX1 -0.0000181 4596 GTEx DepMap Descartes 0.21 21.84
INHA -0.0000475 5274 GTEx DepMap Descartes 0.00 0.64
STAR -0.0000498 5341 GTEx DepMap Descartes 0.00 0.00
FDXR -0.0000569 5547 GTEx DepMap Descartes 0.03 2.17
SCAP -0.0000685 5851 GTEx DepMap Descartes 0.21 11.35
NPC1 -0.0001130 7104 GTEx DepMap Descartes 0.30 15.50
SGCZ -0.0001170 7218 GTEx DepMap Descartes 0.00 0.00
DHCR24 -0.0001293 7563 GTEx DepMap Descartes 0.11 6.31
DHCR7 -0.0001355 7709 GTEx DepMap Descartes 0.11 12.03
FREM2 -0.0001447 7943 GTEx DepMap Descartes 0.00 0.01
PAPSS2 -0.0001617 8360 GTEx DepMap Descartes 0.25 14.03
IGF1R -0.0001634 8395 GTEx DepMap Descartes 0.35 6.30
ERN1 -0.0001673 8478 GTEx DepMap Descartes 0.48 13.56
SH3PXD2B -0.0001694 8527 GTEx DepMap Descartes 0.15 4.97
GSTA4 -0.0002241 9637 GTEx DepMap Descartes 0.17 26.34
TM7SF2 -0.0002504 10056 GTEx DepMap Descartes 0.01 0.55
POR -0.0002601 10203 GTEx DepMap Descartes 0.40 37.52
DNER -0.0002848 10527 GTEx DepMap Descartes 0.01 0.27
FRMD5 -0.0003024 10704 GTEx DepMap Descartes 0.01 0.32
GRAMD1B -0.0003046 10725 GTEx DepMap Descartes 0.10 4.78
APOC1 -0.0003471 11113 GTEx DepMap Descartes 0.07 30.38
SLC16A9 -0.0003483 11129 GTEx DepMap Descartes 0.01 1.70


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10344.32
Median rank of genes in gene set: 10771
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLXNA4 -0.0000148 4531 GTEx DepMap Descartes 0.08 1.18
MAB21L2 -0.0000477 5280 GTEx DepMap Descartes 0.28 17.09
EPHA6 -0.0001212 7359 GTEx DepMap Descartes 0.00 0.00
GAL -0.0001447 7945 GTEx DepMap Descartes 0.07 14.11
TMEFF2 -0.0001558 8230 GTEx DepMap Descartes 0.00 0.28
ANKFN1 -0.0001610 8350 GTEx DepMap Descartes 0.00 0.37
KCNB2 -0.0001682 8498 GTEx DepMap Descartes 0.00 0.09
RGMB -0.0001849 8882 GTEx DepMap Descartes 0.38 18.19
SLC44A5 -0.0001928 9031 GTEx DepMap Descartes 0.02 1.12
RPH3A -0.0001944 9067 GTEx DepMap Descartes 0.00 0.35
NTRK1 -0.0001969 9109 GTEx DepMap Descartes 0.00 0.00
IL7 -0.0002016 9227 GTEx DepMap Descartes 0.02 1.45
EYA4 -0.0002083 9362 GTEx DepMap Descartes 0.00 0.00
HS3ST5 -0.0002390 9882 GTEx DepMap Descartes 0.00 0.00
CCND1 -0.0002523 10080 GTEx DepMap Descartes 2.16 105.67
REEP1 -0.0002716 10379 GTEx DepMap Descartes 0.08 4.05
CNTFR -0.0002736 10399 GTEx DepMap Descartes 0.03 3.97
ELAVL2 -0.0002955 10633 GTEx DepMap Descartes 0.09 4.54
RBFOX1 -0.0002980 10655 GTEx DepMap Descartes 0.01 0.52
ALK -0.0003007 10686 GTEx DepMap Descartes 0.00 0.08
EYA1 -0.0003079 10771 GTEx DepMap Descartes 0.00 0.15
PTCHD1 -0.0003112 10798 GTEx DepMap Descartes 0.01 0.07
RYR2 -0.0003368 11026 GTEx DepMap Descartes 0.05 0.80
GREM1 -0.0003661 11272 GTEx DepMap Descartes 0.05 1.04
FAT3 -0.0003716 11309 GTEx DepMap Descartes 0.02 0.27
NPY -0.0003851 11406 GTEx DepMap Descartes 0.33 116.50
SLC6A2 -0.0003943 11453 GTEx DepMap Descartes 0.02 1.23
ISL1 -0.0003974 11474 GTEx DepMap Descartes 0.21 14.77
TMEM132C -0.0004028 11519 GTEx DepMap Descartes 0.01 0.33
MARCH11 -0.0004291 11658 GTEx DepMap Descartes 0.02 NA


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.65e-23
Mean rank of genes in gene set: 542.61
Median rank of genes in gene set: 91.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLVAP 0.0087237 2 GTEx DepMap Descartes 10.76 1209.61
PTPRB 0.0084249 3 GTEx DepMap Descartes 4.29 93.89
CALCRL 0.0078733 4 GTEx DepMap Descartes 6.08 252.96
CDH5 0.0073036 9 GTEx DepMap Descartes 2.43 158.99
SHANK3 0.0069569 11 GTEx DepMap Descartes 3.27 117.92
SLCO2A1 0.0068811 12 GTEx DepMap Descartes 3.31 235.54
KDR 0.0068613 13 GTEx DepMap Descartes 2.39 109.57
PODXL 0.0068278 15 GTEx DepMap Descartes 3.13 148.94
TIE1 0.0066331 18 GTEx DepMap Descartes 3.61 267.50
MMRN2 0.0065329 19 GTEx DepMap Descartes 2.63 171.82
ROBO4 0.0062728 21 GTEx DepMap Descartes 1.63 96.99
ESM1 0.0057679 26 GTEx DepMap Descartes 4.41 421.55
RAMP2 0.0056238 27 GTEx DepMap Descartes 2.51 808.82
TEK 0.0048318 47 GTEx DepMap Descartes 1.00 56.73
FLT4 0.0047876 48 GTEx DepMap Descartes 1.17 57.58
RASIP1 0.0045225 58 GTEx DepMap Descartes 0.94 89.64
ARHGAP29 0.0043571 64 GTEx DepMap Descartes 2.07 61.55
CLDN5 0.0042328 70 GTEx DepMap Descartes 2.91 357.30
NOTCH4 0.0042093 71 GTEx DepMap Descartes 2.02 94.56
HYAL2 0.0034895 112 GTEx DepMap Descartes 1.14 103.54
KANK3 0.0034444 113 GTEx DepMap Descartes 0.90 89.39
BTNL9 0.0032655 122 GTEx DepMap Descartes 0.76 79.39
EFNB2 0.0031579 129 GTEx DepMap Descartes 3.01 164.75
SHE 0.0030872 136 GTEx DepMap Descartes 0.99 48.46
GALNT15 0.0028452 155 GTEx DepMap Descartes 0.50 NA
CDH13 0.0025940 176 GTEx DepMap Descartes 0.79 28.72
F8 0.0024043 199 GTEx DepMap Descartes 0.53 18.70
MYRIP 0.0023277 206 GTEx DepMap Descartes 0.40 19.65
ID1 0.0021036 244 GTEx DepMap Descartes 3.18 701.28
CEACAM1 0.0020362 261 GTEx DepMap Descartes 0.59 58.21


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10704.32
Median rank of genes in gene set: 12267.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IGFBP3 0.0018636 285 GTEx DepMap Descartes 3.67 390.62
RSPO3 0.0005682 993 GTEx DepMap Descartes 0.24 NA
POSTN 0.0002182 1979 GTEx DepMap Descartes 2.35 163.52
CLDN11 0.0001932 2115 GTEx DepMap Descartes 0.18 17.98
GAS2 -0.0000363 5000 GTEx DepMap Descartes 0.02 0.85
LAMC3 -0.0001191 7284 GTEx DepMap Descartes 0.02 0.60
DKK2 -0.0001334 7663 GTEx DepMap Descartes 0.02 2.28
PRICKLE1 -0.0002908 10586 GTEx DepMap Descartes 0.12 6.66
LRRC17 -0.0003130 10823 GTEx DepMap Descartes 0.03 2.82
HHIP -0.0003187 10876 GTEx DepMap Descartes 0.00 0.00
FREM1 -0.0003277 10952 GTEx DepMap Descartes 0.01 0.28
LOX -0.0003332 10993 GTEx DepMap Descartes 0.14 7.58
ELN -0.0003488 11134 GTEx DepMap Descartes 0.68 50.69
GLI2 -0.0003703 11303 GTEx DepMap Descartes 0.00 0.06
SFRP2 -0.0003742 11327 GTEx DepMap Descartes 0.11 11.67
COL27A1 -0.0004043 11529 GTEx DepMap Descartes 0.26 7.55
ADAMTSL3 -0.0004368 11689 GTEx DepMap Descartes 0.06 1.32
ITGA11 -0.0005167 11969 GTEx DepMap Descartes 0.04 1.01
SCARA5 -0.0005792 12119 GTEx DepMap Descartes 0.02 2.69
PCDH18 -0.0005959 12151 GTEx DepMap Descartes 0.09 2.15
ABCA6 -0.0006488 12244 GTEx DepMap Descartes 0.03 0.86
CDH11 -0.0006503 12250 GTEx DepMap Descartes 0.36 12.19
PAMR1 -0.0006743 12285 GTEx DepMap Descartes 0.05 2.23
MGP -0.0006803 12296 GTEx DepMap Descartes 7.74 1166.46
ADAMTS2 -0.0007135 12332 GTEx DepMap Descartes 0.15 5.14
ABCC9 -0.0007176 12336 GTEx DepMap Descartes 0.24 5.58
BICC1 -0.0007359 12352 GTEx DepMap Descartes 0.04 1.72
CD248 -0.0007497 12372 GTEx DepMap Descartes 0.06 3.09
COL1A1 -0.0007906 12402 GTEx DepMap Descartes 6.97 259.09
COL12A1 -0.0007992 12409 GTEx DepMap Descartes 0.85 11.25


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8220.13
Median rank of genes in gene set: 7692
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FAM155A 0.0003825 1359 GTEx DepMap Descartes 0.36 8.58
AGBL4 0.0000781 3060 GTEx DepMap Descartes 0.02 0.52
LAMA3 0.0000059 4122 GTEx DepMap Descartes 0.18 3.66
CDH12 -0.0000185 4611 GTEx DepMap Descartes 0.01 0.29
SLC35F3 -0.0000239 4710 GTEx DepMap Descartes 0.00 0.17
EML6 -0.0000392 5061 GTEx DepMap Descartes 0.02 0.64
GALNTL6 -0.0000445 5195 GTEx DepMap Descartes 0.01 1.02
CCSER1 -0.0000494 5331 GTEx DepMap Descartes 0.03 NA
PACRG -0.0000800 6162 GTEx DepMap Descartes 0.00 0.00
ST18 -0.0000904 6470 GTEx DepMap Descartes 0.01 0.34
CDH18 -0.0000950 6589 GTEx DepMap Descartes 0.00 0.00
GRM7 -0.0001033 6848 GTEx DepMap Descartes 0.01 0.39
SORCS3 -0.0001037 6858 GTEx DepMap Descartes 0.00 0.00
GRID2 -0.0001065 6938 GTEx DepMap Descartes 0.00 0.07
SPOCK3 -0.0001070 6948 GTEx DepMap Descartes 0.00 0.00
SLC24A2 -0.0001086 6985 GTEx DepMap Descartes 0.00 0.00
ROBO1 -0.0001127 7092 GTEx DepMap Descartes 0.21 7.50
TBX20 -0.0001290 7557 GTEx DepMap Descartes 0.00 0.00
GCH1 -0.0001323 7638 GTEx DepMap Descartes 0.56 55.46
PENK -0.0001373 7746 GTEx DepMap Descartes 0.01 3.92
KSR2 -0.0001711 8559 GTEx DepMap Descartes 0.01 0.17
HTATSF1 -0.0002156 9500 GTEx DepMap Descartes 0.38 31.06
PCSK2 -0.0002229 9619 GTEx DepMap Descartes 0.03 2.28
CNTN3 -0.0002502 10054 GTEx DepMap Descartes 0.01 0.87
KCTD16 -0.0002604 10208 GTEx DepMap Descartes 0.01 0.20
FGF14 -0.0002606 10209 GTEx DepMap Descartes 0.01 0.23
NTNG1 -0.0003007 10685 GTEx DepMap Descartes 0.01 0.75
MGAT4C -0.0003097 10783 GTEx DepMap Descartes 0.01 0.14
DGKK -0.0003108 10794 GTEx DepMap Descartes 0.02 0.52
TENM1 -0.0003126 10817 GTEx DepMap Descartes 0.01 NA


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.82e-01
Mean rank of genes in gene set: 7678.76
Median rank of genes in gene set: 8461
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC25A37 0.0009215 643 GTEx DepMap Descartes 1.62 94.12
MARCH3 0.0004659 1170 GTEx DepMap Descartes 0.39 NA
RAPGEF2 0.0002438 1849 GTEx DepMap Descartes 1.25 37.59
TRAK2 0.0001357 2488 GTEx DepMap Descartes 0.38 15.45
ABCB10 0.0000581 3325 GTEx DepMap Descartes 0.14 10.22
GYPC -0.0000161 4560 GTEx DepMap Descartes 0.69 101.08
GCLC -0.0000377 5019 GTEx DepMap Descartes 0.29 17.98
RHD -0.0000435 5168 GTEx DepMap Descartes 0.00 0.41
SLC25A21 -0.0000808 6189 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000862 6345 GTEx DepMap Descartes 0.01 0.69
TMCC2 -0.0000966 6643 GTEx DepMap Descartes 0.02 3.04
ALAS2 -0.0000982 6687 GTEx DepMap Descartes 0.00 0.00
XPO7 -0.0001319 7632 GTEx DepMap Descartes 0.21 12.56
TFR2 -0.0001526 8153 GTEx DepMap Descartes 0.01 1.02
CAT -0.0001666 8461 GTEx DepMap Descartes 0.39 42.92
FECH -0.0001799 8777 GTEx DepMap Descartes 0.06 1.65
CPOX -0.0002052 9298 GTEx DepMap Descartes 0.08 8.41
MICAL2 -0.0002333 9783 GTEx DepMap Descartes 1.02 34.44
SELENBP1 -0.0002333 9784 GTEx DepMap Descartes 0.24 15.42
SNCA -0.0002642 10262 GTEx DepMap Descartes 0.09 7.82
DENND4A -0.0002789 10459 GTEx DepMap Descartes 0.73 22.69
TSPAN5 -0.0002889 10570 GTEx DepMap Descartes 0.26 21.40
BLVRB -0.0003129 10822 GTEx DepMap Descartes 0.12 17.13
SPECC1 -0.0003327 10989 GTEx DepMap Descartes 0.13 2.65
ANK1 -0.0003425 11069 GTEx DepMap Descartes 0.02 0.40
SPTB -0.0003448 11090 GTEx DepMap Descartes 0.02 0.12
RGS6 -0.0004137 11584 GTEx DepMap Descartes 0.01 0.44
SOX6 -0.0004666 11805 GTEx DepMap Descartes 0.07 1.84
EPB41 -0.0005485 12060 GTEx DepMap Descartes 0.09 3.67
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 7699.03
Median rank of genes in gene set: 9705
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PTPRE 0.0028843 151 GTEx DepMap Descartes 3.13 156.39
CD74 0.0006381 900 GTEx DepMap Descartes 37.01 3233.07
WWP1 0.0005413 1036 GTEx DepMap Descartes 0.50 29.39
RGL1 0.0005337 1048 GTEx DepMap Descartes 0.54 28.02
HRH1 0.0004820 1141 GTEx DepMap Descartes 0.35 19.16
IFNGR1 0.0003646 1413 GTEx DepMap Descartes 0.71 84.41
SLCO2B1 0.0003136 1564 GTEx DepMap Descartes 0.36 14.86
ITPR2 0.0002879 1663 GTEx DepMap Descartes 0.70 13.72
MERTK 0.0001834 2187 GTEx DepMap Descartes 0.12 6.61
SFMBT2 0.0000222 3826 GTEx DepMap Descartes 0.23 8.68
CTSB -0.0000475 5273 GTEx DepMap Descartes 3.04 189.31
SPP1 -0.0000842 6294 GTEx DepMap Descartes 0.11 12.79
CD163L1 -0.0001008 6768 GTEx DepMap Descartes 0.02 0.72
SLC9A9 -0.0001084 6981 GTEx DepMap Descartes 0.11 6.26
LGMN -0.0001166 7204 GTEx DepMap Descartes 0.87 110.84
CPVL -0.0001461 7977 GTEx DepMap Descartes 0.17 22.73
CD14 -0.0001707 8553 GTEx DepMap Descartes 0.31 42.17
FGD2 -0.0001919 9015 GTEx DepMap Descartes 0.02 1.19
CTSC -0.0002219 9602 GTEx DepMap Descartes 1.07 46.29
MS4A4A -0.0002347 9808 GTEx DepMap Descartes 0.04 4.13
CD163 -0.0002355 9824 GTEx DepMap Descartes 0.11 3.34
ATP8B4 -0.0002438 9965 GTEx DepMap Descartes 0.02 0.84
CSF1R -0.0002550 10117 GTEx DepMap Descartes 0.12 4.59
ADAP2 -0.0002664 10287 GTEx DepMap Descartes 0.03 1.06
SLC1A3 -0.0002903 10583 GTEx DepMap Descartes 0.07 2.47
MSR1 -0.0003066 10754 GTEx DepMap Descartes 0.04 2.22
MARCH1 -0.0003341 11003 GTEx DepMap Descartes 0.05 NA
FGL2 -0.0003352 11014 GTEx DepMap Descartes 0.55 27.33
RBPJ -0.0003392 11043 GTEx DepMap Descartes 1.38 50.62
FMN1 -0.0003465 11107 GTEx DepMap Descartes 0.03 0.48


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8367.05
Median rank of genes in gene set: 10891
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LAMA4 0.0022880 211 GTEx DepMap Descartes 3.55 110.77
EDNRB 0.0016465 328 GTEx DepMap Descartes 2.04 123.93
ADAMTS5 0.0013699 421 GTEx DepMap Descartes 0.65 15.80
KCTD12 0.0012481 470 GTEx DepMap Descartes 3.59 162.35
LAMB1 0.0012452 471 GTEx DepMap Descartes 2.84 126.02
VIM 0.0011895 498 GTEx DepMap Descartes 44.51 4214.18
LAMC1 0.0009179 648 GTEx DepMap Descartes 3.85 115.21
PMP22 0.0004571 1186 GTEx DepMap Descartes 1.71 264.75
OLFML2A 0.0001260 2566 GTEx DepMap Descartes 0.87 35.92
STARD13 0.0000446 3491 GTEx DepMap Descartes 0.62 22.63
IL1RAPL2 -0.0000437 5174 GTEx DepMap Descartes 0.00 0.00
HMGA2 -0.0000481 5294 GTEx DepMap Descartes 0.04 1.31
LRRTM4 -0.0001375 7755 GTEx DepMap Descartes 0.00 0.13
COL25A1 -0.0001409 7849 GTEx DepMap Descartes 0.01 0.24
MARCKS -0.0001475 8011 GTEx DepMap Descartes 4.42 264.82
MDGA2 -0.0001535 8172 GTEx DepMap Descartes 0.00 0.00
ERBB4 -0.0001575 8267 GTEx DepMap Descartes 0.01 0.25
COL18A1 -0.0001592 8302 GTEx DepMap Descartes 2.71 97.36
TRPM3 -0.0001958 9086 GTEx DepMap Descartes 0.03 0.73
MPZ -0.0001987 9160 GTEx DepMap Descartes 0.05 11.56
IL1RAPL1 -0.0002181 9542 GTEx DepMap Descartes 0.00 0.00
XKR4 -0.0003130 10824 GTEx DepMap Descartes 0.07 0.54
PTPRZ1 -0.0003284 10958 GTEx DepMap Descartes 0.02 0.75
PTN -0.0003434 11077 GTEx DepMap Descartes 0.08 9.44
SLC35F1 -0.0003477 11122 GTEx DepMap Descartes 0.06 1.92
ERBB3 -0.0003596 11227 GTEx DepMap Descartes 0.05 1.59
NRXN3 -0.0004000 11498 GTEx DepMap Descartes 0.03 0.56
GRIK3 -0.0004057 11537 GTEx DepMap Descartes 0.01 0.30
PPP2R2B -0.0004065 11539 GTEx DepMap Descartes 0.04 1.02
SOX5 -0.0004242 11636 GTEx DepMap Descartes 0.06 1.91


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.86e-01
Mean rank of genes in gene set: 6702.2
Median rank of genes in gene set: 7799
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MMRN1 0.0038912 82 GTEx DepMap Descartes 1.79 80.72
STOM 0.0037121 95 GTEx DepMap Descartes 8.58 778.48
MCTP1 0.0029181 147 GTEx DepMap Descartes 1.82 88.84
CD9 0.0019548 273 GTEx DepMap Descartes 2.76 427.85
MYH9 0.0014629 383 GTEx DepMap Descartes 10.73 384.28
TPM4 0.0013816 414 GTEx DepMap Descartes 6.02 298.95
FLI1 0.0012237 480 GTEx DepMap Descartes 0.83 37.96
HIPK2 0.0009742 608 GTEx DepMap Descartes 2.44 35.00
LIMS1 0.0007907 751 GTEx DepMap Descartes 3.03 150.86
SLC2A3 0.0007858 758 GTEx DepMap Descartes 5.58 376.94
RAP1B 0.0005737 980 GTEx DepMap Descartes 1.54 28.93
TMSB4X 0.0003441 1467 GTEx DepMap Descartes 24.29 3523.39
ITGB3 0.0003355 1494 GTEx DepMap Descartes 0.10 4.58
ACTB 0.0002511 1809 GTEx DepMap Descartes 22.98 2583.39
ZYX 0.0002417 1861 GTEx DepMap Descartes 2.78 283.21
ACTN1 0.0002249 1949 GTEx DepMap Descartes 4.11 225.65
ARHGAP6 0.0000757 3093 GTEx DepMap Descartes 0.12 5.33
ITGA2B -0.0000038 4301 GTEx DepMap Descartes 0.03 2.75
STON2 -0.0000341 4944 GTEx DepMap Descartes 0.07 4.64
TUBB1 -0.0000986 6703 GTEx DepMap Descartes 0.01 1.32
TLN1 -0.0001147 7146 GTEx DepMap Descartes 2.54 67.05
GP1BA -0.0001302 7580 GTEx DepMap Descartes 0.03 1.92
RAB27B -0.0001389 7799 GTEx DepMap Descartes 0.01 0.61
MED12L -0.0001562 8238 GTEx DepMap Descartes 0.02 0.55
P2RX1 -0.0001832 8850 GTEx DepMap Descartes 0.01 0.27
PSTPIP2 -0.0002528 10090 GTEx DepMap Descartes 0.03 5.49
VCL -0.0002839 10515 GTEx DepMap Descartes 1.52 44.57
UBASH3B -0.0002935 10611 GTEx DepMap Descartes 0.17 7.38
SLC24A3 -0.0003004 10682 GTEx DepMap Descartes 0.01 0.16
DOK6 -0.0003160 10853 GTEx DepMap Descartes 0.01 0.15


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8403.83
Median rank of genes in gene set: 11337.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MSN 0.0021000 245 GTEx DepMap Descartes 5.02 345.94
TMSB10 0.0020919 248 GTEx DepMap Descartes 20.03 11747.95
ETS1 0.0012591 465 GTEx DepMap Descartes 5.66 272.73
PITPNC1 0.0012231 481 GTEx DepMap Descartes 2.31 97.72
B2M 0.0009673 613 GTEx DepMap Descartes 58.22 6597.21
PRKCH 0.0009060 658 GTEx DepMap Descartes 1.44 105.27
MBNL1 0.0008702 691 GTEx DepMap Descartes 3.79 151.14
ITPKB 0.0005382 1041 GTEx DepMap Descartes 1.32 57.78
SP100 0.0003724 1389 GTEx DepMap Descartes 1.64 79.34
ABLIM1 0.0003573 1429 GTEx DepMap Descartes 1.41 51.25
FOXP1 0.0003427 1471 GTEx DepMap Descartes 3.67 110.80
ARID5B 0.0001249 2573 GTEx DepMap Descartes 5.19 155.89
CCND3 0.0000857 2981 GTEx DepMap Descartes 0.36 39.15
LEF1 -0.0001483 8032 GTEx DepMap Descartes 0.41 35.36
MCTP2 -0.0001965 9098 GTEx DepMap Descartes 0.06 1.56
RAP1GAP2 -0.0002701 10357 GTEx DepMap Descartes 0.10 3.02
SKAP1 -0.0002928 10608 GTEx DepMap Descartes 0.02 2.11
NCALD -0.0003034 10709 GTEx DepMap Descartes 0.08 4.34
SAMD3 -0.0003159 10851 GTEx DepMap Descartes 0.00 0.11
RCSD1 -0.0003178 10868 GTEx DepMap Descartes 0.12 4.65
SCML4 -0.0003622 11242 GTEx DepMap Descartes 0.00 0.18
TOX -0.0003893 11433 GTEx DepMap Descartes 0.03 0.96
ANKRD44 -0.0004922 11896 GTEx DepMap Descartes 0.09 3.09
FYN -0.0005052 11941 GTEx DepMap Descartes 1.51 128.26
BACH2 -0.0005604 12089 GTEx DepMap Descartes 0.08 2.49
PDE3B -0.0005954 12150 GTEx DepMap Descartes 0.03 0.71
EVL -0.0006066 12169 GTEx DepMap Descartes 0.63 47.13
CCL5 -0.0006114 12180 GTEx DepMap Descartes 0.31 63.54
STK39 -0.0006138 12186 GTEx DepMap Descartes 0.07 4.40
ARHGDIB -0.0006294 12217 GTEx DepMap Descartes 2.28 497.00


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.94e-04
Mean rank of genes in gene set: 50.5
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
VWF 0.0097392 1 GTEx DepMap Descartes 18.72 522.38
MMRN2 0.0065329 19 GTEx DepMap Descartes 2.63 171.82
RAMP3 0.0045781 56 GTEx DepMap Descartes 1.32 300.42
JAM2 0.0032123 126 GTEx DepMap Descartes 1.82 121.63


Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.45e-03
Mean rank of genes in gene set: 46.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PLVAP 0.0087237 2 GTEx DepMap Descartes 10.76 1209.61
SPARCL1 0.0043136 67 GTEx DepMap Descartes 13.61 1140.65
CLDN5 0.0042328 70 GTEx DepMap Descartes 2.91 357.30


B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.25e-02
Mean rank of genes in gene set: 532.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
YBX3 0.0027446 165 GTEx DepMap Descartes 6.61 NA
CD74 0.0006381 900 GTEx DepMap Descartes 37.01 3233.07