Program: 10. NB Cell Line #10 (Mixed).

Program description and justification of annotation: 10
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

	Gene	Loading	Gene.Name	GTEx	DepMap	Descartes	Mean.Counts	Mean.Tpm
1	NEAT1	0.0160377	nuclear paraspeckle assembly transcript 1	GTEx	DepMap	Descartes	70.27	243.50
2	FBN1	0.0108167	fibrillin 1	GTEx	DepMap	Descartes	3.31	20.87
3	GPNMB	0.0096662	glycoprotein nmb	GTEx	DepMap	Descartes	2.06	48.20
4	XIST	0.0093931	X inactive specific transcript	GTEx	DepMap	Descartes	5.00	19.28
5	DST	0.0093653	dystonin	GTEx	DepMap	Descartes	8.01	25.60
6	PXDN	0.0091903	peroxidasin	GTEx	DepMap	Descartes	3.41	31.36
7	LAMB1	0.0089770	laminin subunit beta 1	GTEx	DepMap	Descartes	3.00	38.98
8	LRP1B	0.0082905	LDL receptor related protein 1B	GTEx	DepMap	Descartes	0.64	3.80
9	MALAT1	0.0081589	metastasis associated lung adenocarcinoma transcript 1	GTEx	DepMap	Descartes	363.11	3532.25
10	SYT4	0.0075257	synaptotagmin 4	GTEx	DepMap	Descartes	5.05	73.42
11	COL3A1	0.0074350	collagen type III alpha 1 chain	GTEx	DepMap	Descartes	7.28	101.15
12	MRC2	0.0073489	mannose receptor C type 2	GTEx	DepMap	Descartes	1.36	15.79
13	PCOLCE	0.0073031	procollagen C-endopeptidase enhancer	GTEx	DepMap	Descartes	9.00	301.77
14	TPBG	0.0070279	trophoblast glycoprotein	GTEx	DepMap	Descartes	2.52	26.26
15	TSPAN8	0.0070188	tetraspanin 8	GTEx	DepMap	Descartes	1.97	77.81
16	SEMA3C	0.0068156	semaphorin 3C	GTEx	DepMap	Descartes	1.80	26.81
17	PSAP	0.0065634	prosaposin	GTEx	DepMap	Descartes	3.88	89.42
18	AHNAK	0.0063343	AHNAK nucleoprotein	GTEx	DepMap	Descartes	8.15	29.81
19	EMILIN1	0.0060039	elastin microfibril interfacer 1	GTEx	DepMap	Descartes	2.75	46.25
20	LRP1	0.0058483	LDL receptor related protein 1	GTEx	DepMap	Descartes	1.12	5.20
21	C7	0.0058403	complement C7	GTEx	DepMap	Descartes	3.97	36.83
22	ADAM22	0.0057910	ADAM metallopeptidase domain 22	GTEx	DepMap	Descartes	1.44	8.40
23	PCDHGA7	0.0055999	protocadherin gamma subfamily A, 7	GTEx	DepMap	Descartes	0.21	3.18
24	LTBP1	0.0055519	latent transforming growth factor beta binding protein 1	GTEx	DepMap	Descartes	1.82	20.51
25	C1QTNF6	0.0055102	C1q and TNF related 6	GTEx	DepMap	Descartes	0.50	5.66
26	APLP2	0.0054178	amyloid beta precursor like protein 2	GTEx	DepMap	Descartes	5.08	85.97
27	LGR5	0.0053743	leucine rich repeat containing G protein-coupled receptor 5	GTEx	DepMap	Descartes	0.93	12.63
28	LAMA5	0.0053591	laminin subunit alpha 5	GTEx	DepMap	Descartes	0.78	4.99
29	CLU	0.0053231	clusterin	GTEx	DepMap	Descartes	4.04	93.42
30	TM7SF2	0.0053045	transmembrane 7 superfamily member 2	GTEx	DepMap	Descartes	2.11	55.21
31	PRKCA	0.0052970	protein kinase C alpha	GTEx	DepMap	Descartes	2.33	18.44
32	TRIM56	0.0052932	tripartite motif containing 56	GTEx	DepMap	Descartes	0.54	4.42
33	XYLT1	0.0052554	xylosyltransferase 1	GTEx	DepMap	Descartes	0.62	4.00
34	RNF213	0.0052103	ring finger protein 213	GTEx	DepMap	Descartes	1.97	6.51
35	FSTL1	0.0051975	follistatin like 1	GTEx	DepMap	Descartes	1.85	22.71
36	F10	0.0051291	coagulation factor X	GTEx	DepMap	Descartes	0.22	9.42
37	APOE	0.0050132	apolipoprotein E	GTEx	DepMap	Descartes	4.08	209.02
38	MEG3	0.0049870	maternally expressed 3	GTEx	DepMap	Descartes	5.32	12.83
39	CCNL2	0.0049105	cyclin L2	GTEx	DepMap	Descartes	1.24	25.39
40	LGALS3BP	0.0048557	galectin 3 binding protein	GTEx	DepMap	Descartes	5.18	142.45
41	CTSD	0.0047632	cathepsin D	GTEx	DepMap	Descartes	3.07	91.86
42	LTBP3	0.0047108	latent transforming growth factor beta binding protein 3	GTEx	DepMap	Descartes	1.18	15.14
43	MATN2	0.0046903	matrilin 2	GTEx	DepMap	Descartes	0.61	11.27
44	UNC5C	0.0046808	unc-5 netrin receptor C	GTEx	DepMap	Descartes	1.52	9.35
45	AKAP6	0.0046780	A-kinase anchoring protein 6	GTEx	DepMap	Descartes	0.73	3.00
46	VTN	0.0046583	vitronectin	GTEx	DepMap	Descartes	0.25	8.58
47	SSC5D	0.0046577	scavenger receptor cysteine rich family member with 5 domains	GTEx	DepMap	Descartes	0.25	3.92
48	NRP1	0.0046235	neuropilin 1	GTEx	DepMap	Descartes	1.30	14.92
49	LAMB2	0.0045877	laminin subunit beta 2	GTEx	DepMap	Descartes	0.47	5.23
50	CYBA	0.0045829	cytochrome b-245 alpha chain	GTEx	DepMap	Descartes	3.19	126.67

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UMAP plots showing activity of gene expression program identified in community:10. NB Cell Line #10 (Mixed)

Interactive UMAP Plot

Interactive Boxplot

CNV Data procured from inferCNV.
Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
The top cells expressing this GEP (purple)
Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes

mSigDB Cell Types Gene Set:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
DESCARTES_FETAL_THYMUS_STROMAL_CELLS	1.10e-10	24.58	10.73	1.85e-08	7.39e-08	10FBN1, COL3A1, MRC2, PCOLCE, SEMA3C, EMILIN1, LRP1, FSTL1, LGALS3BP, SSC5D	137
CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL	6.54e-10	25.38	10.58	7.32e-08	4.39e-07	9FBN1, LAMB1, MRC2, PCOLCE, LRP1, C7, FSTL1, MEG3, MATN2	117
RUBENSTEIN_SKELETAL_MUSCLE_FBN1_FAP_CELLS	2.84e-12	17.68	8.71	1.31e-09	1.91e-09	14FBN1, GPNMB, DST, COL3A1, PCOLCE, SEMA3C, PSAP, AHNAK, LRP1, CLU, FSTL1, F10, MEG3, LAMB2	289
TRAVAGLINI_LUNG_ADVENTITIAL_FIBROBLAST_CELL	3.90e-12	17.24	8.49	1.31e-09	2.62e-09	14FBN1, GPNMB, COL3A1, MRC2, PCOLCE, SEMA3C, LRP1, C7, FSTL1, MEG3, LGALS3BP, MATN2, NRP1, LAMB2	296
MENON_FETAL_KIDNEY_3_STROMAL_CELLS	7.32e-07	22.70	7.67	3.51e-05	4.91e-04	6XIST, DST, PXDN, COL3A1, FSTL1, MEG3	81
HU_FETAL_RETINA_RPE	5.57e-11	15.75	7.59	1.24e-08	3.73e-08	13NEAT1, FBN1, GPNMB, PXDN, SEMA3C, PSAP, LTBP1, APLP2, FSTL1, APOE, CTSD, LTBP3, LAMB2	292
RUBENSTEIN_SKELETAL_MUSCLE_FAP_CELLS	2.68e-08	16.14	6.79	2.08e-06	1.80e-05	9GPNMB, MALAT1, COL3A1, PCOLCE, PSAP, LRP1, FSTL1, MEG3, LGALS3BP	179
AIZARANI_LIVER_C21_STELLATE_CELLS_1	5.33e-08	14.83	6.24	3.58e-06	3.58e-05	9FBN1, LAMB1, COL3A1, PCOLCE, LRP1, C7, FSTL1, LGALS3BP, MATN2	194
GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR	2.37e-06	18.31	6.23	9.96e-05	1.59e-03	6COL3A1, MRC2, PCOLCE, C7, C1QTNF6, MATN2	99
GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS	3.42e-10	10.94	5.51	4.58e-08	2.29e-07	15FBN1, PXDN, COL3A1, MRC2, PCOLCE, EMILIN1, LRP1, LAMA5, FSTL1, F10, APOE, MEG3, UNC5C, NRP1, LAMB2	505
FAN_OVARY_CL5_HEALTHY_SELECTABLE_FOLLICLE_THECAL_CELL	2.80e-08	11.49	5.25	2.08e-06	1.88e-05	11PXDN, LAMB1, COL3A1, PCOLCE, EMILIN1, C7, FSTL1, APOE, MEG3, MATN2, NRP1	318
HU_FETAL_RETINA_FIBROBLAST	1.78e-08	10.59	4.99	1.71e-06	1.20e-05	12FBN1, PXDN, LAMB1, COL3A1, MRC2, PCOLCE, TPBG, AHNAK, EMILIN1, FSTL1, LAMB2, CYBA	385
FAN_OVARY_CL6_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_2	1.86e-07	10.78	4.76	1.04e-05	1.25e-04	10COL3A1, PSAP, EMILIN1, C7, FSTL1, APOE, MEG3, LGALS3BP, CTSD, MATN2	300
CUI_DEVELOPING_HEART_TRABECULAR_ATRIAL_CARDIOMYOCYTE	5.80e-06	11.82	4.43	2.18e-04	3.89e-03	7DST, MALAT1, PSAP, LTBP1, APLP2, LGALS3BP, LAMB2	179
MENON_FETAL_KIDNEY_4_PODOCYTES	1.43e-05	10.23	3.83	4.58e-04	9.63e-03	7NEAT1, DST, MALAT1, PSAP, AHNAK, APLP2, CCNL2	206
BUSSLINGER_ESOPHAGEAL_QUIESCENT_BASAL_CELLS	2.38e-04	14.88	3.79	5.32e-03	1.60e-01	4GPNMB, DST, LAMA5, CLU	77
AIZARANI_LIVER_C33_STELLATE_CELLS_2	1.33e-04	11.47	3.49	3.30e-03	8.91e-02	5DST, PXDN, LAMB1, COL3A1, C7	126
MANNO_MIDBRAIN_NEUROTYPES_HPERIC	1.17e-07	6.87	3.47	7.15e-06	7.87e-05	15FBN1, GPNMB, PXDN, LAMB1, COL3A1, MRC2, PCOLCE, EMILIN1, LRP1, RNF213, FSTL1, APOE, LGALS3BP, LAMB2, CYBA	795
LAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS	6.36e-05	9.97	3.42	1.78e-03	4.27e-02	6NEAT1, DST, AHNAK, C7, PRKCA, UNC5C	177
CUI_DEVELOPING_HEART_SMOOTH_MUSCLE_CELL	8.97e-04	17.71	3.40	1.67e-02	6.02e-01	3COL3A1, PCOLCE, F10	48

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mSigDB Hallmark Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
HALLMARK_ANGIOGENESIS	1.18e-05	33.91	8.38	2.97e-04	5.91e-04	4COL3A1, FSTL1, VTN, NRP1	36
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	1.19e-05	10.54	3.95	2.97e-04	5.94e-04	7FBN1, DST, COL3A1, PCOLCE, LRP1, FSTL1, MATN2	200
HALLMARK_COAGULATION	2.09e-03	8.11	2.09	3.05e-02	1.05e-01	4FBN1, LRP1, CLU, F10	138
HALLMARK_UV_RESPONSE_DN	2.44e-03	7.76	2.00	3.05e-02	1.22e-01	4COL3A1, LTBP1, PRKCA, NRP1	144
HALLMARK_HEDGEHOG_SIGNALING	8.94e-03	15.30	1.73	7.45e-02	4.47e-01	2UNC5C, NRP1	36
HALLMARK_COMPLEMENT	7.71e-03	5.55	1.44	7.45e-02	3.85e-01	4LRP1, CLU, F10, CTSD	200
HALLMARK_CHOLESTEROL_HOMEOSTASIS	3.47e-02	7.23	0.84	2.48e-01	1.00e+00	2CLU, TM7SF2	74
HALLMARK_XENOBIOTIC_METABOLISM	4.35e-02	4.05	0.80	2.72e-01	1.00e+00	3F10, APOE, VTN	200
HALLMARK_PROTEIN_SECRETION	5.52e-02	5.54	0.64	3.07e-01	1.00e+00	2DST, TSPAN8	96
HALLMARK_IL2_STAT5_SIGNALING	1.83e-01	2.64	0.31	5.78e-01	1.00e+00	2AHNAK, NRP1	199
HALLMARK_HYPOXIA	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2TPBG, PRKCA	200
HALLMARK_ADIPOGENESIS	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2APLP2, APOE	200
HALLMARK_MYOGENESIS	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2COL3A1, CLU	200
HALLMARK_INTERFERON_GAMMA_RESPONSE	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2RNF213, LGALS3BP	200
HALLMARK_KRAS_SIGNALING_UP	1.85e-01	2.63	0.31	5.78e-01	1.00e+00	2GPNMB, NRP1	200
HALLMARK_NOTCH_SIGNALING	1.20e-01	8.23	0.20	5.78e-01	1.00e+00	1PRKCA	32
HALLMARK_INTERFERON_ALPHA_RESPONSE	3.20e-01	2.66	0.07	9.41e-01	1.00e+00	1LGALS3BP	97
HALLMARK_PEROXISOME	3.39e-01	2.48	0.06	9.41e-01	1.00e+00	1SEMA3C	104
HALLMARK_FATTY_ACID_METABOLISM	4.66e-01	1.62	0.04	9.77e-01	1.00e+00	1XIST	158
HALLMARK_APOPTOSIS	4.72e-01	1.59	0.04	9.77e-01	1.00e+00	1CLU	161

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KEGG Pathways:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
KEGG_ECM_RECEPTOR_INTERACTION	1.93e-05	17.57	5.30	3.59e-03	3.59e-03	5LAMB1, COL3A1, LAMA5, VTN, LAMB2	84
KEGG_FOCAL_ADHESION	1.20e-04	8.83	3.04	1.12e-02	2.24e-02	6LAMB1, COL3A1, LAMA5, PRKCA, VTN, LAMB2	199
KEGG_SMALL_CELL_LUNG_CANCER	4.44e-03	9.85	1.92	2.75e-01	8.25e-01	3LAMB1, LAMA5, LAMB2	84
KEGG_AXON_GUIDANCE	1.42e-02	6.33	1.24	6.62e-01	1.00e+00	3SEMA3C, UNC5C, NRP1	129
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	3.05e-02	7.77	0.90	1.00e+00	1.00e+00	2C7, F10	69
KEGG_PATHWAYS_IN_CANCER	3.70e-02	3.39	0.88	1.00e+00	1.00e+00	4LAMB1, LAMA5, PRKCA, LAMB2	325
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	7.67e-02	4.57	0.53	1.00e+00	1.00e+00	2PRKCA, CYBA	116
KEGG_LYSOSOME	8.24e-02	4.38	0.51	1.00e+00	1.00e+00	2PSAP, CTSD	121
KEGG_STEROID_BIOSYNTHESIS	6.56e-02	15.93	0.37	1.00e+00	1.00e+00	1TM7SF2	17
KEGG_ALZHEIMERS_DISEASE	1.39e-01	3.18	0.37	1.00e+00	1.00e+00	2LRP1, APOE	166
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE	8.40e-02	12.14	0.29	1.00e+00	1.00e+00	1XYLT1	22
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	9.85e-02	10.19	0.24	1.00e+00	1.00e+00	1XYLT1	26
KEGG_PRION_DISEASES	1.30e-01	7.50	0.18	1.00e+00	1.00e+00	1C7	35
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	1.54e-01	6.22	0.15	1.00e+00	1.00e+00	1PRKCA	42
KEGG_VIBRIO_CHOLERAE_INFECTION	1.94e-01	4.81	0.12	1.00e+00	1.00e+00	1PRKCA	54
KEGG_NON_SMALL_CELL_LUNG_CANCER	1.94e-01	4.81	0.12	1.00e+00	1.00e+00	1PRKCA	54
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	2.00e-01	4.64	0.11	1.00e+00	1.00e+00	1PRKCA	56
KEGG_GLIOMA	2.28e-01	3.99	0.10	1.00e+00	1.00e+00	1PRKCA	65
KEGG_LONG_TERM_POTENTIATION	2.43e-01	3.70	0.09	1.00e+00	1.00e+00	1PRKCA	70
KEGG_LONG_TERM_DEPRESSION	2.43e-01	3.70	0.09	1.00e+00	1.00e+00	1PRKCA	70

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CHR Positional Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
chr11q13	7.84e-02	2.61	0.68	1.00e+00	1.00e+00	4NEAT1, MALAT1, TM7SF2, LTBP3	421
chr12q21	9.06e-02	4.13	0.48	1.00e+00	1.00e+00	2TSPAN8, LGR5	128
chr7q21	1.36e-01	3.21	0.38	1.00e+00	1.00e+00	2SEMA3C, ADAM22	164
chr7q22	2.03e-01	2.47	0.29	1.00e+00	1.00e+00	2PCOLCE, TRIM56	213
chr17q25	3.22e-01	1.77	0.21	1.00e+00	1.00e+00	2RNF213, LGALS3BP	297
chr2q22	2.37e-01	3.81	0.09	1.00e+00	1.00e+00	1LRP1B	68
chr4q22	2.43e-01	3.70	0.09	1.00e+00	1.00e+00	1UNC5C	70
chr6q14	3.09e-01	2.77	0.07	1.00e+00	1.00e+00	1TPBG	93
chr17q24	3.12e-01	2.74	0.07	1.00e+00	1.00e+00	1PRKCA	94
chr18q12	3.17e-01	2.68	0.07	1.00e+00	1.00e+00	1SYT4	96
chr7p15	3.17e-01	2.68	0.07	1.00e+00	1.00e+00	1GPNMB	96
chr2p22	3.23e-01	2.63	0.06	1.00e+00	1.00e+00	1LTBP1	98
chr14q12	3.31e-01	2.55	0.06	1.00e+00	1.00e+00	1AKAP6	101
chr2q32	3.49e-01	2.38	0.06	1.00e+00	1.00e+00	1COL3A1	108
chr17q23	3.59e-01	2.30	0.06	1.00e+00	1.00e+00	1MRC2	112
chr2p25	3.72e-01	2.20	0.05	1.00e+00	1.00e+00	1PXDN	117
chr19q13	4.39e-01	0.45	0.05	1.00e+00	1.00e+00	2APOE, SSC5D	1165
chr5p13	3.99e-01	2.01	0.05	1.00e+00	1.00e+00	1C7	128
chr8p21	3.99e-01	2.01	0.05	1.00e+00	1.00e+00	1CLU	128
chr7q31	4.01e-01	1.99	0.05	1.00e+00	1.00e+00	1LAMB1	129

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Transcription Factor Targets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
CEBPE_TARGET_GENES	3.53e-04	24.91	4.72	4.00e-01	4.00e-01	3MALAT1, TSPAN8, SEMA3C	35
STAT5B_01	3.07e-03	5.56	1.71	1.00e+00	1.00e+00	5PCOLCE, C7, CLU, VTN, NRP1	255
ZNF239_TARGET_GENES	9.92e-03	14.46	1.64	1.00e+00	1.00e+00	2NEAT1, TM7SF2	38
EGR1_01	3.84e-03	5.26	1.62	1.00e+00	1.00e+00	5MRC2, PCOLCE, TPBG, APLP2, VTN	269
YKACATTT_UNKNOWN	5.25e-03	4.87	1.50	1.00e+00	1.00e+00	5LRP1B, ADAM22, LTBP1, CLU, UNC5C	290
EGR2_01	7.45e-03	5.60	1.45	1.00e+00	1.00e+00	4MRC2, PCOLCE, AHNAK, VTN	198
MED25_TARGET_GENES	9.53e-03	7.39	1.45	1.00e+00	1.00e+00	3NEAT1, MALAT1, LTBP1	111
SOX11_TARGET_GENES	1.31e-02	12.39	1.41	1.00e+00	1.00e+00	2XIST, MALAT1	44
FOXC1_TARGET_GENES	1.43e-02	11.83	1.35	1.00e+00	1.00e+00	2LRP1, LTBP3	46
TTCYNRGAA_STAT5B_01	1.01e-02	4.13	1.27	1.00e+00	1.00e+00	5PCOLCE, C7, CLU, VTN, NRP1	341
SUPT16H_TARGET_GENES	5.64e-03	2.52	1.25	1.00e+00	1.00e+00	14NEAT1, FBN1, DST, MALAT1, MRC2, LRP1, TM7SF2, XYLT1, RNF213, CTSD, VTN, SSC5D, NRP1, LAMB2	1944
AP3_Q6	1.64e-02	4.40	1.14	1.00e+00	1.00e+00	4LRP1, FSTL1, UNC5C, NRP1	251
P53_02	1.73e-02	4.33	1.12	1.00e+00	1.00e+00	4SYT4, MRC2, AHNAK, AKAP6	255
STAT_01	1.80e-02	4.28	1.11	1.00e+00	1.00e+00	4PCOLCE, CLU, VTN, NRP1	258
P53_DECAMER_Q2	1.80e-02	4.28	1.11	1.00e+00	1.00e+00	4DST, LRP1, LTBP1, AKAP6	258
STAT5A_01	1.82e-02	4.26	1.11	1.00e+00	1.00e+00	4PCOLCE, C7, VTN, NRP1	259
MYOGENIN_Q6	1.82e-02	4.26	1.11	1.00e+00	1.00e+00	4SYT4, XYLT1, RNF213, CCNL2	259
IK2_01	2.15e-02	4.04	1.05	1.00e+00	1.00e+00	4AHNAK, LRP1, LTBP1, RNF213	273
IK1_01	2.38e-02	3.91	1.02	1.00e+00	1.00e+00	4AHNAK, LRP1, LTBP1, RNF213	282
KMT2D_TARGET_GENES	2.79e-02	2.58	0.98	1.00e+00	1.00e+00	7NEAT1, DST, MALAT1, CTSD, LTBP3, AKAP6, NRP1	796

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GO Biological Processes:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GOBP_BASEMENT_MEMBRANE_ASSEMBLY	2.61e-05	66.24	11.62	4.00e-02	1.95e-01	3PXDN, LAMB1, LAMB2	15
GOBP_EXTRACELLULAR_MATRIX_ASSEMBLY	8.71e-07	34.63	10.20	6.52e-03	6.52e-03	5PXDN, LAMB1, EMILIN1, LTBP3, LAMB2	45
GOBP_REGULATION_OF_CDC42_PROTEIN_SIGNAL_TRANSDUCTION	3.22e-04	103.49	9.64	8.93e-02	1.00e+00	2APOE, NRP1	7
GOBP_MAINTENANCE_OF_PROTEIN_LOCATION_IN_EXTRACELLULAR_REGION	3.22e-04	103.49	9.64	8.93e-02	1.00e+00	2FBN1, LTBP1	7
GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE	3.22e-04	103.49	9.64	8.93e-02	1.00e+00	2LRP1, APOE	7
GOBP_REGULATION_OF_AMYLOID_BETA_CLEARANCE	5.49e-05	49.70	8.99	4.35e-02	4.11e-01	3LRP1, CLU, APOE	19
GOBP_DENDRITE_ARBORIZATION	4.28e-04	86.37	8.33	1.09e-01	1.00e+00	2TPBG, NRP1	8
GOBP_SEQUESTERING_OF_EXTRACELLULAR_LIGAND_FROM_RECEPTOR	6.85e-04	64.86	6.55	1.35e-01	1.00e+00	2FBN1, LTBP1	10
GOBP_ELASTIC_FIBER_ASSEMBLY	6.85e-04	64.86	6.55	1.35e-01	1.00e+00	2EMILIN1, LTBP3	10
GOBP_TRANSFORMING_GROWTH_FACTOR_BETA_ACTIVATION	8.35e-04	57.69	5.91	1.45e-01	1.00e+00	2LTBP1, LTBP3	11
GOBP_BASEMENT_MEMBRANE_ORGANIZATION	2.22e-04	29.50	5.54	8.28e-02	1.00e+00	3PXDN, LAMB1, LAMB2	30
GOBP_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION	9.99e-04	51.89	5.39	1.59e-01	1.00e+00	2FBN1, LTBP1	12
GOBP_NEGATIVE_REGULATION_OF_AMYLOID_FIBRIL_FORMATION	9.99e-04	51.89	5.39	1.59e-01	1.00e+00	2CLU, APOE	12
GOBP_CDC42_PROTEIN_SIGNAL_TRANSDUCTION	1.37e-03	43.30	4.59	1.90e-01	1.00e+00	2APOE, NRP1	14
GOBP_AMYLOID_BETA_CLEARANCE	4.51e-04	22.75	4.33	1.09e-01	1.00e+00	3LRP1, CLU, APOE	38
GOBP_LIPOPROTEIN_CATABOLIC_PROCESS	1.58e-03	39.95	4.27	2.00e-01	1.00e+00	2APOE, CTSD	15
GOBP_REGULATION_OF_AMYLOID_FIBRIL_FORMATION	1.58e-03	39.95	4.27	2.00e-01	1.00e+00	2CLU, APOE	15
GOBP_GANGLION_DEVELOPMENT	1.80e-03	37.11	3.99	2.17e-01	1.00e+00	2UNC5C, NRP1	16
GOBP_AXON_EXTENSION	8.31e-05	12.74	3.87	4.78e-02	6.21e-01	5SEMA3C, LRP1, APOE, NRP1, LAMB2	114
GOBP_NEURON_PROJECTION_EXTENSION	4.18e-05	10.78	3.70	4.35e-02	3.13e-01	6SYT4, SEMA3C, LRP1, APOE, NRP1, LAMB2	164

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Immunological Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_DN	7.19e-05	9.74	3.35	3.01e-01	3.50e-01	6AHNAK, LRP1, APLP2, XYLT1, LGALS3BP, NRP1	181
GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_DN	1.24e-04	8.78	3.02	3.01e-01	6.03e-01	6FBN1, SYT4, TPBG, SEMA3C, PSAP, FSTL1	200
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP	8.02e-04	7.63	2.34	4.78e-01	1.00e+00	5PCOLCE, LAMA5, FSTL1, CTSD, LAMB2	187
GSE22611_MUTANT_NOD2_VS_CTRL_TRANSDUCED_HEK293T_CELL_DN	9.88e-04	7.27	2.23	4.78e-01	1.00e+00	5GPNMB, LRP1B, F10, LGALS3BP, UNC5C	196
GSE21546_WT_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP	1.06e-03	7.16	2.19	4.78e-01	1.00e+00	5GPNMB, LTBP1, XYLT1, FSTL1, AKAP6	199
GSE17721_4_VS_24H_CPG_BMDC_UP	1.08e-03	7.12	2.18	4.78e-01	1.00e+00	5MRC2, TPBG, F10, CCNL2, MATN2	200
GSE24634_TEFF_VS_TCONV_DAY10_IN_CULTURE_DN	1.08e-03	7.12	2.18	4.78e-01	1.00e+00	5GPNMB, PSAP, APLP2, VTN, NRP1	200
GSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_24H_UP	1.08e-03	7.12	2.18	4.78e-01	1.00e+00	5PSAP, AHNAK, LRP1, APLP2, CLU	200
GSE5679_CTRL_VS_PPARG_LIGAND_ROSIGLITAZONE_TREATED_DC_DN	1.08e-03	7.12	2.18	4.78e-01	1.00e+00	5AHNAK, PRKCA, CCNL2, LTBP3, MATN2	200
GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_UP	1.08e-03	7.12	2.18	4.78e-01	1.00e+00	5PXDN, CLU, MEG3, NRP1, LAMB2	200
GSE24726_WT_VS_E2_2_KO_PDC_DAY6_POST_DELETION_DN	1.08e-03	7.12	2.18	4.78e-01	1.00e+00	5XIST, MALAT1, LRP1, APOE, NRP1	200
GSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN	3.10e-03	7.25	1.87	8.35e-01	1.00e+00	4XIST, DST, MALAT1, CCNL2	154
GSE37605_NOD_VS_C57BL6_IRES_GFP_TREG_UP	3.47e-03	7.01	1.81	8.35e-01	1.00e+00	4XIST, APLP2, XYLT1, NRP1	159
GSE3565_DUSP1_VS_WT_SPLENOCYTES_UP	3.79e-03	6.83	1.77	8.35e-01	1.00e+00	4AHNAK, XYLT1, CTSD, NRP1	163
GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD8_TCELL_DN	4.58e-03	6.47	1.67	8.35e-01	1.00e+00	4LTBP1, RNF213, LGALS3BP, CYBA	172
GSE21360_PRIMARY_VS_QUATERNARY_MEMORY_CD8_TCELL_UP	4.77e-03	6.39	1.65	8.35e-01	1.00e+00	4GPNMB, AHNAK, RNF213, LGALS3BP	174
GSE6259_33D1_POS_DC_VS_CD4_TCELL_DN	4.96e-03	6.32	1.63	8.35e-01	1.00e+00	4GPNMB, DST, ADAM22, APOE	176
GSE21360_NAIVE_VS_SECONDARY_MEMORY_CD8_TCELL_DN	4.96e-03	6.32	1.63	8.35e-01	1.00e+00	4AHNAK, APLP2, RNF213, LGALS3BP	176
GSE3565_CTRL_VS_LPS_INJECTED_DUSP1_KO_SPLENOCYTES_UP	5.47e-03	6.14	1.59	8.35e-01	1.00e+00	4AHNAK, XYLT1, CTSD, NRP1	181
GSE35543_IN_VIVO_NTREG_VS_CONVERTED_EX_ITREG_UP	6.70e-03	5.78	1.50	8.35e-01	1.00e+00	4SYT4, SEMA3C, MATN2, LAMB2	192

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol	TF Rank	DNA Binding Domain	Motif Status	IUPAC PWM	GTEx	DepMap	Decartes
FBN1	2	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
CLU	29	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of NF-kappaB transcription factor activity, but there is no DBD and no evidence of DNA binding.
PLXNB2	85	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
NOTCH2	105	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transmembrane receptor protein that operates far upstream in the signaling cascade
PLXNA4	112	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade (PMID: 12591607).
MACF1	134	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because Vasquerizas 2009 includes it with an x. No DBD and no other data to support being a TF.
GLIS3	146	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
NFKBIZ	153	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
NFE2L1	160	Yes	Known motif	Obligate heteromer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Tested on HT-SELEX and PBM. Neither yielded a motif. Likely an obligate heteromer (PMID: 23661758).
UBR4	165	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
RUNX1	170	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None
PLXNB3	214	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a semaphorin receptor that operates far upstream on the signaling cascade.
HOOK2	224	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
NPAS2	226	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
EDA2R	241	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity. Not DNA binding.
KMT2C	244	No	Unlikely to be sequence specific TF	Low specificity DNA-binding protein	No motif	Has a putative AT-hook	Based on the alignment, it is quite different from all other HMG proteins. It is borderline to say that it is a HMG at all.
ATXN7	249	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ATXN7 SCA7 domain facilitates interactions with histone dimers (PMID: 20634802)
TCF25	259	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Only evidence is based on (PMID:16574069), which claims that hnulp1 (TCF25) contains a possible bHLH domain and that it represses transcription in a Gal4-forced recruitment assay.
GOLGB1	280	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Golgi resident transmembrane protein that regulates glycosylation of other proteins (PMID: 27226319)
LRP6	286	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Cell surface receptor that is in the beginning of the WNT signaling cascade. GO annotation has no evidence of DNA-binding activity (PMID: 14739301).

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID	Singler label	Singler Delta	Activity Score	Top Singler Raw Scores
SKNSH_TCGATTTGTGGATCGA-1	Neurons	0.08	210.82	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Smooth_muscle_cells:vascular: 0.17, Neuroepithelial_cell:ESC-derived: 0.17, Fibroblasts:foreskin: 0.16, MSC: 0.16, iPS_cells:foreskin_fibrobasts: 0.16, Smooth_muscle_cells:umbilical_vein: 0.16, Tissue_stem_cells:lipoma-derived_MSC: 0.16, Endothelial_cells:HUVEC:FPV-infected: 0.16, iPS_cells:CRL2097_foreskin: 0.16
SKNSH_TCATCCGGTTCAAGGG-1	Smooth_muscle_cells	0.18	144.98	Raw ScoresMSC: 0.4, Smooth_muscle_cells:vascular: 0.39, Fibroblasts:foreskin: 0.39, iPS_cells:CRL2097_foreskin: 0.39, iPS_cells:skin_fibroblast: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, Smooth_muscle_cells:vascular:IL-17: 0.37, Tissue_stem_cells:lipoma-derived_MSC: 0.37, Neurons:Schwann_cell: 0.37, iPS_cells:PDB_fibroblasts: 0.37
BE2C_ATCGGATAGCCAAGTG-1	Neurons	0.10	136.59	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Neuroepithelial_cell:ESC-derived: 0.24, Tissue_stem_cells:CD326-CD56+: 0.24, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.23, iPS_cells:fibroblast-derived:Retroviral_transf: 0.23, iPS_cells:PDB_2lox-22: 0.23, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.23, iPS_cells:PDB_2lox-17: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23
SKNSH_TCAATCTCACCTCGTT-1	Fibroblasts	0.05	133.55	Raw ScoresFibroblasts:breast: 0.12, Smooth_muscle_cells:vascular: 0.11, iPS_cells:adipose_stem_cells: 0.11, Fibroblasts:foreskin: 0.11, Neurons:Schwann_cell: 0.11, Smooth_muscle_cells:vascular:IL-17: 0.11, Tissue_stem_cells:BM_MSC:osteogenic: 0.11, Chondrocytes:MSC-derived: 0.11, iPS_cells:foreskin_fibrobasts: 0.11, Osteoblasts: 0.11
SKNSH_TACTTCATCTTCCTAA-1	Neurons	0.05	129.95	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, Endothelial_cells:HUVEC:FPV-infected: 0.16, Endothelial_cells:HUVEC: 0.15, Endothelial_cells:HUVEC:H5N1-infected: 0.15, Endothelial_cells:HUVEC:VEGF: 0.15, Endothelial_cells:HUVEC:PR8-infected: 0.15, Endothelial_cells:HUVEC:IL-1b: 0.15, Neurons:Schwann_cell: 0.15, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.15, Smooth_muscle_cells:vascular: 0.15
SKNSH_CAGTTAGCAATGTCTG-1	Neurons	0.14	123.65	Raw ScoresSmooth_muscle_cells:vascular: 0.27, Smooth_muscle_cells:bronchial: 0.27, Fibroblasts:breast: 0.27, iPS_cells:CRL2097_foreskin: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Smooth_muscle_cells:vascular:IL-17: 0.27, iPS_cells:skin_fibroblast: 0.26, MSC: 0.26, Neurons:Schwann_cell: 0.26, Osteoblasts: 0.26
SKNSH_CAAGGGATCCCGTAAA-1	Neurons	0.05	122.42	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.14, Neuroepithelial_cell:ESC-derived: 0.14, iPS_cells:PDB_2lox-5: 0.13, iPS_cells:PDB_2lox-22: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_2lox-17: 0.13, iPS_cells:PDB_2lox-21: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13
SKNSH_GATAGCTTCCACTAGA-1	Neurons	0.03	110.89	Raw ScoresiPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.13, Neurons:adrenal_medulla_cell_line: 0.13, Endothelial_cells:HUVEC:VEGF: 0.13, Smooth_muscle_cells:bronchial:vit_D: 0.13, Endothelial_cells:HUVEC: 0.13, Smooth_muscle_cells:bronchial: 0.13, Endothelial_cells:HUVEC:B._anthracis_LT: 0.13, Endothelial_cells:HUVEC:FPV-infected: 0.13, Tissue_stem_cells:CD326-CD56+: 0.13, Endothelial_cells:HUVEC:H5N1-infected: 0.13
GIMEN_TTAGGCATCTGTCTCG-1	MSC	0.28	103.66	Raw ScoresMSC: 0.45, Smooth_muscle_cells:vascular: 0.43, Fibroblasts:foreskin: 0.42, Tissue_stem_cells:dental_pulp: 0.41, iPS_cells:skin_fibroblast: 0.41, iPS_cells:CRL2097_foreskin: 0.41, iPS_cells:foreskin_fibrobasts: 0.41, Tissue_stem_cells:lipoma-derived_MSC: 0.41, iPS_cells:PDB_fibroblasts: 0.4, Smooth_muscle_cells:umbilical_vein: 0.4
SKNAS_CTTGAGATCCAGTACA-1	Smooth_muscle_cells	0.16	102.89	Raw ScoresSmooth_muscle_cells:vascular: 0.19, Smooth_muscle_cells:vascular:IL-17: 0.19, Fibroblasts:breast: 0.17, Tissue_stem_cells:BM_MSC: 0.17, Tissue_stem_cells:BM_MSC:osteogenic: 0.17, iPS_cells:fibroblasts: 0.17, Osteoblasts: 0.17, iPS_cells:adipose_stem_cells: 0.17, Fibroblasts:foreskin: 0.17, iPS_cells:skin_fibroblast: 0.17
BE2C_CAGCACGTCAGCCTCT-1	Neurons	0.09	102.30	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.17, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.15, iPS_cells:PDB_2lox-5: 0.15, iPS_cells:PDB_2lox-22: 0.15, iPS_cells:PDB_2lox-17: 0.15
SKNSH_TGAGGAGTCGCTCTAC-1	Smooth_muscle_cells	0.18	101.90	Raw ScoresiPS_cells:CRL2097_foreskin: 0.33, Smooth_muscle_cells:vascular: 0.33, MSC: 0.33, Neurons:adrenal_medulla_cell_line: 0.32, Smooth_muscle_cells:vascular:IL-17: 0.32, Smooth_muscle_cells:bronchial: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32, Fibroblasts:breast: 0.32, iPS_cells:skin_fibroblast: 0.32, iPS_cells:foreskin_fibrobasts: 0.32
SKNSH_GGCAGTCCATTGGCAT-1	Neurons	0.04	100.17	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.14, Endothelial_cells:HUVEC:FPV-infected: 0.14, Endothelial_cells:HUVEC: 0.14, Neurons:Schwann_cell: 0.14, Endothelial_cells:HUVEC:IL-1b: 0.14, Endothelial_cells:HUVEC:H5N1-infected: 0.14, Smooth_muscle_cells:vascular: 0.14, MSC: 0.13, Fibroblasts:foreskin: 0.13
SKNSH_ATTTCACAGAAGAGCA-1	Smooth_muscle_cells	0.22	97.37	Raw ScoresiPS_cells:CRL2097_foreskin: 0.37, MSC: 0.36, Fibroblasts:breast: 0.36, Smooth_muscle_cells:vascular: 0.36, Fibroblasts:foreskin: 0.36, iPS_cells:skin_fibroblast: 0.36, Smooth_muscle_cells:vascular:IL-17: 0.36, iPS_cells:foreskin_fibrobasts: 0.36, Smooth_muscle_cells:bronchial: 0.35, Smooth_muscle_cells:bronchial:vit_D: 0.35
SKNSH_GGTGGCTAGATTGCGG-1	Smooth_muscle_cells	0.18	96.23	Raw ScoresSmooth_muscle_cells:vascular: 0.34, Neurons:adrenal_medulla_cell_line: 0.34, Fibroblasts:breast: 0.33, Smooth_muscle_cells:vascular:IL-17: 0.33, Smooth_muscle_cells:bronchial: 0.33, iPS_cells:CRL2097_foreskin: 0.33, MSC: 0.33, Smooth_muscle_cells:bronchial:vit_D: 0.33, iPS_cells:skin_fibroblast: 0.32, Neurons:Schwann_cell: 0.32
SKNSH_AGAGAGCAGGTTACAA-1	MSC	0.04	96.08	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.11, MSC: 0.11, Fibroblasts:foreskin: 0.11, iPS_cells:CRL2097_foreskin: 0.11, Smooth_muscle_cells:bronchial: 0.11, Neuroepithelial_cell:ESC-derived: 0.1, iPS_cells:foreskin_fibrobasts: 0.1, Smooth_muscle_cells:vascular: 0.1, Smooth_muscle_cells:bronchial:vit_D: 0.1, Fibroblasts:breast: 0.1
SKNSH_CGAGAAGGTCCCTAAA-1	Neurons	0.13	94.46	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Smooth_muscle_cells:vascular: 0.22, iPS_cells:CRL2097_foreskin: 0.21, MSC: 0.21, Smooth_muscle_cells:bronchial: 0.21, Smooth_muscle_cells:bronchial:vit_D: 0.21, Fibroblasts:breast: 0.21, Fibroblasts:foreskin: 0.21, Smooth_muscle_cells:vascular:IL-17: 0.21, iPS_cells:foreskin_fibrobasts: 0.21
BE2C_TTTCCTCAGCGCCTTG-1	Neurons	0.06	93.12	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neurons:Schwann_cell: 0.12, Endothelial_cells:HUVEC:FPV-infected: 0.12, iPS_cells:skin_fibroblast-derived: 0.12, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.12, iPS_cells:iPS:minicircle-derived: 0.12, Embryonic_stem_cells: 0.12, Endothelial_cells:HUVEC:PR8-infected: 0.12, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.12, Endothelial_cells:HUVEC: 0.12
SKNSH_TTTGGAGTCCAGTGTA-1	Smooth_muscle_cells	0.15	91.68	Raw ScoresiPS_cells:CRL2097_foreskin: 0.31, Smooth_muscle_cells:vascular: 0.3, MSC: 0.3, Fibroblasts:breast: 0.3, Smooth_muscle_cells:vascular:IL-17: 0.3, iPS_cells:skin_fibroblast: 0.3, iPS_cells:foreskin_fibrobasts: 0.3, Smooth_muscle_cells:bronchial: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.29, iPS_cells:adipose_stem_cells: 0.29
GIMEN_CATGCCTCATCTTAGG-1	Fibroblasts	0.06	90.03	Raw ScoresiPS_cells:CRL2097_foreskin: 0.11, Neurons:Schwann_cell: 0.11, Smooth_muscle_cells:vascular: 0.11, Tissue_stem_cells:iliac_MSC: 0.11, Smooth_muscle_cells:bronchial:vit_D: 0.11, Fibroblasts:breast: 0.11, MSC: 0.1, Fibroblasts:foreskin: 0.1, Smooth_muscle_cells:bronchial: 0.1, Smooth_muscle_cells:vascular:IL-17: 0.1
BE2C_GAGACCCTCTTCTAAC-1	Neurons	0.23	85.92	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.52, Neuroepithelial_cell:ESC-derived: 0.43, iPS_cells:PDB_2lox-22: 0.41, iPS_cells:PDB_1lox-21Puro-20: 0.41, iPS_cells:PDB_1lox-21Puro-26: 0.41, iPS_cells:PDB_2lox-21: 0.41, iPS_cells:PDB_2lox-17: 0.41, iPS_cells:PDB_1lox-17Puro-10: 0.41, iPS_cells:PDB_2lox-5: 0.41, Tissue_stem_cells:CD326-CD56+: 0.41
GIMEN_CGGACACTCAGGAAGC-1	MSC	0.09	85.82	Raw ScoresSmooth_muscle_cells:vascular: 0.15, MSC: 0.15, Endothelial_cells:HUVEC:VEGF: 0.14, Endothelial_cells:HUVEC: 0.14, Endothelial_cells:HUVEC:FPV-infected: 0.14, Endothelial_cells:HUVEC:H5N1-infected: 0.14, Endothelial_cells:lymphatic: 0.14, Fibroblasts:foreskin: 0.14, Endothelial_cells:blood_vessel: 0.13, Endothelial_cells:HUVEC:PR8-infected: 0.13
SKNSH_AGTACTGGTCTGTCCT-1	Smooth_muscle_cells	0.24	84.73	Raw ScoresiPS_cells:CRL2097_foreskin: 0.46, MSC: 0.46, iPS_cells:skin_fibroblast: 0.45, iPS_cells:foreskin_fibrobasts: 0.45, Fibroblasts:breast: 0.45, Smooth_muscle_cells:vascular: 0.45, Smooth_muscle_cells:vascular:IL-17: 0.45, Fibroblasts:foreskin: 0.45, Smooth_muscle_cells:bronchial: 0.45, Tissue_stem_cells:BM_MSC: 0.44
SKNSH_CATACTTTCAAACTGC-1	MSC	0.22	83.88	Raw ScoresMSC: 0.33, iPS_cells:skin_fibroblast: 0.32, iPS_cells:CRL2097_foreskin: 0.31, iPS_cells:foreskin_fibrobasts: 0.31, Smooth_muscle_cells:vascular: 0.31, Fibroblasts:foreskin: 0.31, Fibroblasts:breast: 0.31, iPS_cells:PDB_fibroblasts: 0.3, Tissue_stem_cells:dental_pulp: 0.3, Tissue_stem_cells:lipoma-derived_MSC: 0.3
GIMEN_TGCAGTATCTGGGTCG-1	MSC	0.08	83.85	Raw ScoresMSC: 0.14, iPS_cells:skin_fibroblast: 0.14, Tissue_stem_cells:lipoma-derived_MSC: 0.14, Fibroblasts:foreskin: 0.13, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.13, iPS_cells:PDB_fibroblasts: 0.13, Smooth_muscle_cells:vascular: 0.13, iPS_cells:fibroblasts: 0.13, iPS_cells:CRL2097_foreskin: 0.13, iPS_cells:foreskin_fibrobasts: 0.13
SKNSH_GGGCCATCAGAGTTGG-1	Neurons	0.21	83.42	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, iPS_cells:CRL2097_foreskin: 0.42, Neurons:Schwann_cell: 0.42, Smooth_muscle_cells:vascular: 0.42, MSC: 0.42, Fibroblasts:breast: 0.42, iPS_cells:foreskin_fibrobasts: 0.41, Smooth_muscle_cells:bronchial: 0.41, Smooth_muscle_cells:bronchial:vit_D: 0.41, Smooth_muscle_cells:vascular:IL-17: 0.41
SKNSH_GAAGGACAGCAGAAAG-1	MSC	0.14	83.38	Raw ScoresMSC: 0.26, iPS_cells:CRL2097_foreskin: 0.26, Fibroblasts:foreskin: 0.26, Smooth_muscle_cells:vascular: 0.26, iPS_cells:skin_fibroblast: 0.25, iPS_cells:foreskin_fibrobasts: 0.25, Fibroblasts:breast: 0.25, iPS_cells:PDB_fibroblasts: 0.25, iPS_cells:fibroblasts: 0.25, Neurons:Schwann_cell: 0.24
SKNSH_GGTGGCTTCGTAGCCG-1	Smooth_muscle_cells	0.22	79.35	Raw ScoresMSC: 0.51, Fibroblasts:breast: 0.51, iPS_cells:foreskin_fibrobasts: 0.51, iPS_cells:skin_fibroblast: 0.5, iPS_cells:CRL2097_foreskin: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, Smooth_muscle_cells:vascular: 0.5, Smooth_muscle_cells:bronchial: 0.5, Smooth_muscle_cells:bronchial:vit_D: 0.5, Fibroblasts:foreskin: 0.5
SKNSH_GGGTCACCAACTGAAA-1	Neurons	0.03	77.98	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.14, Neurons:Schwann_cell: 0.13, Fibroblasts:foreskin: 0.13, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.13, iPS_cells:fibroblast-derived:Retroviral_transf: 0.13, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.13, iPS_cells:iPS:minicircle-derived: 0.13, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.12, iPS_cells:skin_fibroblast-derived: 0.12, Embryonic_stem_cells: 0.12
SKNSH_GTGCTTCCAGCTGTGC-1	Neurons	0.17	77.97	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.44, MSC: 0.41, Neurons:Schwann_cell: 0.4, Smooth_muscle_cells:vascular: 0.4, Fibroblasts:breast: 0.4, iPS_cells:skin_fibroblast: 0.4, Smooth_muscle_cells:vascular:IL-17: 0.4, iPS_cells:CRL2097_foreskin: 0.4, Fibroblasts:foreskin: 0.4, iPS_cells:foreskin_fibrobasts: 0.4
BE2C_ATCGTAGTCAGGACGA-1	Neurons	0.05	77.43	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.14, iPS_cells:PDB_2lox-22: 0.13, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.13, iPS_cells:PDB_2lox-17: 0.13, Tissue_stem_cells:CD326-CD56+: 0.13, iPS_cells:PDB_2lox-21: 0.13, iPS_cells:fibroblast-derived:Retroviral_transf: 0.13, iPS_cells:iPS:minicircle-derived: 0.13, iPS_cells:PDB_2lox-5: 0.13
SKNSH_CCACGAGAGAATAGTC-1	Neurons	0.13	75.39	Raw ScoresMSC: 0.29, Fibroblasts:foreskin: 0.28, iPS_cells:CRL2097_foreskin: 0.28, iPS_cells:skin_fibroblast: 0.28, Neurons:adrenal_medulla_cell_line: 0.28, iPS_cells:foreskin_fibrobasts: 0.27, Smooth_muscle_cells:vascular: 0.27, Neurons:Schwann_cell: 0.27, iPS_cells:fibroblasts: 0.27, Tissue_stem_cells:lipoma-derived_MSC: 0.27
SKNSH_TAGTGCAAGACCCGCT-1	MSC	0.18	74.85	Raw ScoresMSC: 0.31, iPS_cells:skin_fibroblast: 0.3, iPS_cells:CRL2097_foreskin: 0.3, Smooth_muscle_cells:vascular: 0.3, Fibroblasts:foreskin: 0.29, iPS_cells:foreskin_fibrobasts: 0.29, iPS_cells:fibroblasts: 0.29, iPS_cells:PDB_fibroblasts: 0.29, Fibroblasts:breast: 0.29, Tissue_stem_cells:lipoma-derived_MSC: 0.28
SKNSH_ATCATTCGTTCAATCG-1	MSC	0.13	73.92	Raw ScoresMSC: 0.24, Smooth_muscle_cells:vascular: 0.23, iPS_cells:CRL2097_foreskin: 0.23, Smooth_muscle_cells:vascular:IL-17: 0.23, Fibroblasts:breast: 0.23, Fibroblasts:foreskin: 0.22, iPS_cells:skin_fibroblast: 0.22, Neurons:Schwann_cell: 0.22, iPS_cells:foreskin_fibrobasts: 0.22, iPS_cells:fibroblasts: 0.22
SKNSH_CGGGTGTGTGGTTCTA-1	MSC	0.14	72.63	Raw ScoresMSC: 0.24, Fibroblasts:foreskin: 0.24, Smooth_muscle_cells:vascular: 0.23, iPS_cells:skin_fibroblast: 0.23, iPS_cells:CRL2097_foreskin: 0.23, Neurons:Schwann_cell: 0.23, Tissue_stem_cells:dental_pulp: 0.23, iPS_cells:foreskin_fibrobasts: 0.23, iPS_cells:PDB_fibroblasts: 0.22, iPS_cells:fibroblasts: 0.22
MHHNB11_GGGATGACACCGTGCA-1	Neurons	0.35	72.62	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.73, Neuroepithelial_cell:ESC-derived: 0.6, iPS_cells:PDB_1lox-21Puro-20: 0.58, iPS_cells:PDB_1lox-21Puro-26: 0.58, iPS_cells:PDB_1lox-17Puro-10: 0.57, iPS_cells:PDB_2lox-22: 0.57, iPS_cells:PDB_1lox-17Puro-5: 0.57, Astrocyte:Embryonic_stem_cell-derived: 0.57, iPS_cells:PDB_2lox-21: 0.56, iPS_cells:PDB_2lox-17: 0.56
GIMEN_ATAGGCTCACAAGTGG-1	Smooth_muscle_cells	0.07	72.45	Raw ScoresSmooth_muscle_cells:vascular: 0.18, MSC: 0.17, Fibroblasts:foreskin: 0.17, Neurons:Schwann_cell: 0.16, Tissue_stem_cells:lipoma-derived_MSC: 0.16, iPS_cells:skin_fibroblast: 0.16, Fibroblasts:breast: 0.16, Smooth_muscle_cells:vascular:IL-17: 0.16, iPS_cells:CRL2097_foreskin: 0.16, iPS_cells:foreskin_fibrobasts: 0.16
SKNSH_CCCTGATGTACTGACT-1	Smooth_muscle_cells	0.19	72.23	Raw ScoresSmooth_muscle_cells:bronchial: 0.26, iPS_cells:CRL2097_foreskin: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26, Smooth_muscle_cells:vascular: 0.26, MSC: 0.26, Smooth_muscle_cells:vascular:IL-17: 0.25, Fibroblasts:breast: 0.25, Fibroblasts:foreskin: 0.25, iPS_cells:skin_fibroblast: 0.25, iPS_cells:foreskin_fibrobasts: 0.25
SKNSH_TGTTTGTCAATTGCGT-1	Smooth_muscle_cells	0.22	72.11	Raw ScoresFibroblasts:breast: 0.46, Smooth_muscle_cells:vascular: 0.46, Smooth_muscle_cells:vascular:IL-17: 0.46, MSC: 0.45, iPS_cells:skin_fibroblast: 0.45, iPS_cells:CRL2097_foreskin: 0.45, Smooth_muscle_cells:bronchial: 0.45, iPS_cells:foreskin_fibrobasts: 0.45, Smooth_muscle_cells:bronchial:vit_D: 0.45, iPS_cells:adipose_stem_cells: 0.44
SKNSH_AAGACAACAGTCACGC-1	Fibroblasts	0.16	72.07	Raw ScoresiPS_cells:CRL2097_foreskin: 0.24, MSC: 0.24, Smooth_muscle_cells:vascular: 0.24, Smooth_muscle_cells:vascular:IL-17: 0.24, iPS_cells:skin_fibroblast: 0.23, Fibroblasts:foreskin: 0.23, Fibroblasts:breast: 0.23, iPS_cells:foreskin_fibrobasts: 0.23, Smooth_muscle_cells:bronchial: 0.23, Smooth_muscle_cells:bronchial:vit_D: 0.23
GIMEN_GCGTGCATCGACTCCT-1	MSC	0.07	70.90	Raw ScoresMSC: 0.27, Neurons:adrenal_medulla_cell_line: 0.26, Endothelial_cells:HUVEC:IL-1b: 0.26, Endothelial_cells:HUVEC: 0.26, Tissue_stem_cells:lipoma-derived_MSC: 0.26, Fibroblasts:foreskin: 0.26, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.26, iPS_cells:skin_fibroblast: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, Neurons:Schwann_cell: 0.25
BE2C_TAGACCAGTCCCTGAG-1	Neurons	0.10	70.82	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.2, iPS_cells:PDB_2lox-22: 0.2, iPS_cells:PDB_2lox-17: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.2, iPS_cells:PDB_2lox-21: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:fibroblast-derived:Retroviral_transf: 0.2, iPS_cells:PDB_2lox-5: 0.2
SKNSH_AGACCCGCATACTGAC-1	MSC	0.28	70.77	Raw ScoresMSC: 0.59, iPS_cells:skin_fibroblast: 0.57, Fibroblasts:foreskin: 0.57, iPS_cells:foreskin_fibrobasts: 0.57, Tissue_stem_cells:lipoma-derived_MSC: 0.56, iPS_cells:CRL2097_foreskin: 0.56, Smooth_muscle_cells:umbilical_vein: 0.56, Smooth_muscle_cells:vascular: 0.55, iPS_cells:PDB_fibroblasts: 0.55, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.55
SKNSH_TACCGGGCATCCCGTT-1	Fibroblasts	0.04	70.03	Raw ScoresSmooth_muscle_cells:umbilical_vein: 0.14, Tissue_stem_cells:lipoma-derived_MSC: 0.14, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.14, Fibroblasts:foreskin: 0.14, MSC: 0.14, iPS_cells:foreskin_fibrobasts: 0.13, Tissue_stem_cells:dental_pulp: 0.13, Smooth_muscle_cells:vascular: 0.13, iPS_cells:CRL2097_foreskin: 0.13, Smooth_muscle_cells:vascular:IL-17: 0.13
BE2C_CTAACCCGTAGCGTCC-1	Neurons	0.22	69.78	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.56, Neuroepithelial_cell:ESC-derived: 0.46, iPS_cells:PDB_1lox-21Puro-20: 0.45, iPS_cells:PDB_1lox-21Puro-26: 0.45, iPS_cells:PDB_1lox-17Puro-10: 0.45, iPS_cells:PDB_2lox-22: 0.44, iPS_cells:PDB_1lox-17Puro-5: 0.44, iPS_cells:PDB_2lox-17: 0.44, iPS_cells:PDB_2lox-21: 0.44, Embryonic_stem_cells: 0.44
SKNSH_AACCACACAGCGACCT-1	Neurons	0.09	69.25	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, iPS_cells:CRL2097_foreskin: 0.15, Smooth_muscle_cells:vascular: 0.15, Fibroblasts:breast: 0.15, iPS_cells:skin_fibroblast: 0.15, MSC: 0.15, iPS_cells:fibroblasts: 0.15, Smooth_muscle_cells:vascular:IL-17: 0.15, iPS_cells:PDB_fibroblasts: 0.14, iPS_cells:foreskin_fibrobasts: 0.14
GIMEN_GGGAGTATCACTACGA-1	MSC	0.09	68.63	Raw ScoresSmooth_muscle_cells:vascular: 0.15, MSC: 0.14, Smooth_muscle_cells:bronchial: 0.14, Smooth_muscle_cells:bronchial:vit_D: 0.14, Smooth_muscle_cells:vascular:IL-17: 0.14, iPS_cells:skin_fibroblast: 0.14, iPS_cells:fibroblasts: 0.13, Neurons:Schwann_cell: 0.13, Fibroblasts:foreskin: 0.13, iPS_cells:PDB_fibroblasts: 0.13
SKNSH_TGCACGGAGCTCAGAG-1	Neurons	0.11	68.61	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Smooth_muscle_cells:bronchial: 0.22, Smooth_muscle_cells:bronchial:vit_D: 0.22, iPS_cells:CRL2097_foreskin: 0.22, Smooth_muscle_cells:vascular: 0.22, Smooth_muscle_cells:vascular:IL-17: 0.22, Fibroblasts:breast: 0.22, MSC: 0.21, iPS_cells:skin_fibroblast: 0.21, iPS_cells:adipose_stem_cells: 0.21
SKNSH_AGAAATGAGTTCCAGT-1	Neuroepithelial_cell	0.07	68.17	Raw ScoresNeuroepithelial_cell:ESC-derived: 0.14, Embryonic_stem_cells: 0.13, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.13, Tissue_stem_cells:CD326-CD56+: 0.13, Fibroblasts:breast: 0.13, Neurons:adrenal_medulla_cell_line: 0.13, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.13, MSC: 0.13, Tissue_stem_cells:iliac_MSC: 0.13, Tissue_stem_cells:lipoma-derived_MSC: 0.13
SKNSH_TCGGGTGAGAGGTCGT-1	Neurons	0.26	68.04	Raw ScoresNeurons:adrenal_medulla_cell_line: 0.58, Neuroepithelial_cell:ESC-derived: 0.49, Tissue_stem_cells:CD326-CD56+: 0.47, Astrocyte:Embryonic_stem_cell-derived: 0.46, Embryonic_stem_cells: 0.46, iPS_cells:PDB_2lox-22: 0.46, iPS_cells:PDB_1lox-21Puro-20: 0.46, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.46, iPS_cells:PDB_2lox-21: 0.46, MSC: 0.46

Below shows the significant enrichments of this GEP for literature curated gene lists
This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.77e-04
Mean rank of genes in gene set: 3689.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
C7	0.0058403	21	GTEx	DepMap	Descartes	3.97	36.83
PDGFD	0.0030701	140	GTEx	DepMap	Descartes	0.20	3.14
PDGFRB	0.0027684	177	GTEx	DepMap	Descartes	0.53	5.82
HGF	0.0019391	352	GTEx	DepMap	Descartes	3.20	39.32
LIF	0.0013447	643	GTEx	DepMap	Descartes	0.02	0.81
C3	0.0010157	953	GTEx	DepMap	Descartes	0.00	0.00
CFB	0.0007076	1318	GTEx	DepMap	Descartes	0.01	0.34
IGF1	0.0006425	1405	GTEx	DepMap	Descartes	0.00	0.00
IL33	0.0005148	1658	GTEx	DepMap	Descartes	0.01	0.49
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75
RGMA	0.0002076	2496	GTEx	DepMap	Descartes	0.00	0.00
SERPING1	0.0000500	3022	GTEx	DepMap	Descartes	0.16	4.17
PDPN	-0.0000188	3325	GTEx	DepMap	Descartes	0.00	0.00
CXCL14	-0.0001307	3785	GTEx	DepMap	Descartes	0.00	0.00
IL10	-0.0002084	4125	GTEx	DepMap	Descartes	0.00	0.00
SCARA5	-0.0002215	4198	GTEx	DepMap	Descartes	0.00	0.00
CFD	-0.0003470	4799	GTEx	DepMap	Descartes	0.01	0.48
CXCL2	-0.0005267	5435	GTEx	DepMap	Descartes	0.00	0.00
SCARA3	-0.0007534	6210	GTEx	DepMap	Descartes	0.15	2.15
GPX3	-0.0008128	6361	GTEx	DepMap	Descartes	0.12	3.75
IGFBP6	-0.0009846	6813	GTEx	DepMap	Descartes	1.97	95.32
CCL2	-0.0011128	7149	GTEx	DepMap	Descartes	0.23	25.77
IL1R1	-0.0015436	8099	GTEx	DepMap	Descartes	0.09	1.32
CXCL12	-0.0015482	8106	GTEx	DepMap	Descartes	0.09	1.84
SOD2	-0.0025546	9597	GTEx	DepMap	Descartes	0.63	1.95

Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.51e-03
Mean rank of genes in gene set: 4742.92
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
THBS2	0.0037708	84	GTEx	DepMap	Descartes	0.36	4.32
TNC	0.0036756	93	GTEx	DepMap	Descartes	0.97	6.90
COL11A1	0.0033579	117	GTEx	DepMap	Descartes	0.07	0.74
MMP11	0.0032267	129	GTEx	DepMap	Descartes	0.39	6.73
COL5A1	0.0031547	135	GTEx	DepMap	Descartes	0.70	6.77
VCAN	0.0030492	142	GTEx	DepMap	Descartes	2.74	15.75
FN1	0.0021965	274	GTEx	DepMap	Descartes	4.12	37.60
MEF2C	0.0014448	569	GTEx	DepMap	Descartes	0.32	2.61
WNT5A	0.0013621	630	GTEx	DepMap	Descartes	0.29	3.72
COL13A1	0.0013240	656	GTEx	DepMap	Descartes	0.08	2.14
MYLK	0.0013209	660	GTEx	DepMap	Descartes	1.65	9.98
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
TGFB2	0.0008615	1117	GTEx	DepMap	Descartes	0.12	1.45
TGFBR2	0.0007573	1230	GTEx	DepMap	Descartes	0.31	4.33
ITGA7	0.0006758	1359	GTEx	DepMap	Descartes	0.03	0.51
POSTN	0.0005461	1587	GTEx	DepMap	Descartes	0.74	15.88
COL10A1	0.0005131	1663	GTEx	DepMap	Descartes	0.01	0.08
MYH11	0.0004940	1714	GTEx	DepMap	Descartes	0.00	0.00
THBS1	0.0004430	1818	GTEx	DepMap	Descartes	1.11	10.82
COL5A2	0.0004400	1825	GTEx	DepMap	Descartes	0.18	2.48
TMEM119	0.0004224	1870	GTEx	DepMap	Descartes	0.48	7.60
COL14A1	0.0003101	2188	GTEx	DepMap	Descartes	0.00	0.00
COL8A1	0.0002567	2346	GTEx	DepMap	Descartes	0.23	3.21
ACTG2	-0.0000617	3499	GTEx	DepMap	Descartes	0.00	0.00
THY1	-0.0001342	3805	GTEx	DepMap	Descartes	4.68	58.73
MMP2	-0.0003501	4814	GTEx	DepMap	Descartes	2.78	37.39
COL12A1	-0.0004296	5093	GTEx	DepMap	Descartes	0.06	0.30
IGFBP3	-0.0004820	5277	GTEx	DepMap	Descartes	1.17	29.03
COL4A1	-0.0006089	5744	GTEx	DepMap	Descartes	0.34	3.09
DCN	-0.0008165	6373	GTEx	DepMap	Descartes	0.12	1.45
TGFBR1	-0.0012002	7374	GTEx	DepMap	Descartes	0.32	2.47
VEGFA	-0.0012075	7386	GTEx	DepMap	Descartes	0.41	1.05
BGN	-0.0012522	7509	GTEx	DepMap	Descartes	0.29	7.08
COL15A1	-0.0016592	8311	GTEx	DepMap	Descartes	0.00	0.00
PGF	-0.0019523	8806	GTEx	DepMap	Descartes	0.09	0.97
COL1A1	-0.0019570	8815	GTEx	DepMap	Descartes	4.36	51.78
TGFB1	-0.0022006	9157	GTEx	DepMap	Descartes	1.24	26.58
MYL9	-0.0023373	9339	GTEx	DepMap	Descartes	0.00	0.00
ACTA2	-0.0023770	9384	GTEx	DepMap	Descartes	0.31	12.82
IGFBP7	-0.0025130	9556	GTEx	DepMap	Descartes	0.09	4.09
HOPX	-0.0029339	9986	GTEx	DepMap	Descartes	0.00	0.00
LUM	-0.0029889	10034	GTEx	DepMap	Descartes	0.46	9.72
CNN2	-0.0038102	10712	GTEx	DepMap	Descartes	0.50	11.14
TAGLN	-0.0043604	11049	GTEx	DepMap	Descartes	0.39	8.18
TPM2	-0.0055695	11573	GTEx	DepMap	Descartes	3.11	59.28
RGS5	-0.0063788	11796	GTEx	DepMap	Descartes	29.36	155.90
CNN3	-0.0069684	11920	GTEx	DepMap	Descartes	3.55	62.73
TPM1	-0.0078902	12086	GTEx	DepMap	Descartes	11.92	159.35

Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.03e-03
Mean rank of genes in gene set: 3270.58
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FBN1	0.0108167	2	GTEx	DepMap	Descartes	3.31	20.87
FSTL1	0.0051975	35	GTEx	DepMap	Descartes	1.85	22.71
ITM2A	0.0015594	515	GTEx	DepMap	Descartes	0.10	3.35
POSTN	0.0005461	1587	GTEx	DepMap	Descartes	0.74	15.88
COL5A2	0.0004400	1825	GTEx	DepMap	Descartes	0.18	2.48
FBN2	0.0003958	1944	GTEx	DepMap	Descartes	0.17	0.57
COL14A1	0.0003101	2188	GTEx	DepMap	Descartes	0.00	0.00
GSN	0.0001221	2786	GTEx	DepMap	Descartes	0.51	4.50
PENK	-0.0003358	4739	GTEx	DepMap	Descartes	0.00	0.00
SFRP1	-0.0010644	7013	GTEx	DepMap	Descartes	4.37	39.84
IGFBP5	-0.0011052	7134	GTEx	DepMap	Descartes	2.74	19.99
GAS1	-0.0024588	9479	GTEx	DepMap	Descartes	0.21	4.17

Stroma (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Stroma cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.51e-03
Mean rank of genes in gene set: 1730.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
COL5A1	0.0031547	135	GTEx	DepMap	Descartes	0.70	6.77
FN1	0.0021965	274	GTEx	DepMap	Descartes	4.12	37.60
COL6A1	0.0013339	652	GTEx	DepMap	Descartes	1.05	13.05
GPC3	-0.0012824	7580	GTEx	DepMap	Descartes	0.00	0.00

Protein maturation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.31e-03
Mean rank of genes in gene set: 597
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDIA3	0.0035822	100	GTEx	DepMap	Descartes	5.11	88.71
OS9	0.0027688	176	GTEx	DepMap	Descartes	1.25	18.90
RPN2	0.0005827	1515	GTEx	DepMap	Descartes	3.92	92.52

Stromal 1 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.81e-03
Mean rank of genes in gene set: 3080.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP14	0.0040982	67	GTEx	DepMap	Descartes	0.27	3.89
HMGA2	0.0014838	553	GTEx	DepMap	Descartes	0.58	7.80
COL27A1	0.0014662	562	GTEx	DepMap	Descartes	0.06	0.82
TGFB2	0.0008615	1117	GTEx	DepMap	Descartes	0.12	1.45
IGSF3	0.0003640	2029	GTEx	DepMap	Descartes	0.51	3.02
NFIB	-0.0010351	6934	GTEx	DepMap	Descartes	3.35	18.97
CHD3	-0.0032825	10301	GTEx	DepMap	Descartes	1.05	7.43

EMT III (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in non-cycling cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-03
Mean rank of genes in gene set: 2052
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2	0.0040536	72	GTEx	DepMap	Descartes	1.88	17.09
LAMB3	0.0017091	439	GTEx	DepMap	Descartes	0.08	1.00
LAMA3	0.0001333	2744	GTEx	DepMap	Descartes	0.01	0.02
JUP	-0.0003885	4953	GTEx	DepMap	Descartes	0.28	4.18

M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.64e-02
Mean rank of genes in gene set: 3944
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLR4	0.0013887	619	GTEx	DepMap	Descartes	0.09	0.51
IL33	0.0005148	1658	GTEx	DepMap	Descartes	0.01	0.49
IL18	0.0003189	2151	GTEx	DepMap	Descartes	0.00	0.00
CD80	0.0002071	2498	GTEx	DepMap	Descartes	0.00	0.00
CXCL16	-0.0001419	3839	GTEx	DepMap	Descartes	0.04	0.85
CD14	-0.0002669	4411	GTEx	DepMap	Descartes	0.00	0.00
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0.00	0.00
TNF	-0.0004907	5308	GTEx	DepMap	Descartes	0.00	0.00
ITGAX	-0.0005136	5387	GTEx	DepMap	Descartes	0.00	0.00
IL1B	-0.0006024	5709	GTEx	DepMap	Descartes	0.00	0.00
CCL2	-0.0011128	7149	GTEx	DepMap	Descartes	0.23	25.77

Schwann cell precursor Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454). These genes were used to show cells transitioning from a SCP to a symphathoblast state in their human fetal single-cell RNA-seq data.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.95e-02
Mean rank of genes in gene set: 3911.9
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL2A1	0.0014329	577	GTEx	DepMap	Descartes	0.00	0.00
POSTN	0.0005461	1587	GTEx	DepMap	Descartes	0.74	15.88
MOXD1	0.0001547	2648	GTEx	DepMap	Descartes	0.77	13.66
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
NGFR	-0.0001377	3818	GTEx	DepMap	Descartes	0.01	0.33
MPZ	-0.0003477	4804	GTEx	DepMap	Descartes	0.01	0.11
S100B	-0.0007702	6254	GTEx	DepMap	Descartes	0.04	1.17
GAS7	-0.0008949	6577	GTEx	DepMap	Descartes	0.01	0.04
MBP	-0.0009808	6804	GTEx	DepMap	Descartes	0.07	0.43

Endothelial Cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.24e-02
Mean rank of genes in gene set: 1545.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ENG	0.0023410	243	GTEx	DepMap	Descartes	0.67	12.91
VWF	0.0001003	2848	GTEx	DepMap	Descartes	0.01	0.12

SCPs mouse and neuroblastoma (Olsen)
Similar to above, but for genes common to neuroblastoma SCP-like cells (as determined from their UMAP plot) and mouse SCP cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.42e-02
Mean rank of genes in gene set: 4285.91
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DST	0.0093653	5	GTEx	DepMap	Descartes	8.01	25.60
SEMA3B	0.0018330	391	GTEx	DepMap	Descartes	0.12	2.61
GPM6B	0.0002291	2425	GTEx	DepMap	Descartes	0.20	1.72
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
FXYD1	-0.0000994	3664	GTEx	DepMap	Descartes	0.01	0.33
MPZ	-0.0003477	4804	GTEx	DepMap	Descartes	0.01	0.11
NRXN1	-0.0006055	5725	GTEx	DepMap	Descartes	0.15	0.26
LGI4	-0.0006598	5907	GTEx	DepMap	Descartes	0.00	0.00
S100B	-0.0007702	6254	GTEx	DepMap	Descartes	0.04	1.17
CNN3	-0.0069684	11920	GTEx	DepMap	Descartes	3.55	62.73

Stromal 3 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.66e-02
Mean rank of genes in gene set: 2527
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OLFML3	0.0032167	132	GTEx	DepMap	Descartes	0.57	19.46
NOTCH3	0.0007250	1282	GTEx	DepMap	Descartes	0.13	1.15
PIK3R1	-0.0007451	6167	GTEx	DepMap	Descartes	1.46	9.36

Mesenchymal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.72e-02
Mean rank of genes in gene set: 3043.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
COL6A1	0.0013339	652	GTEx	DepMap	Descartes	1.05	13.05
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
VIM	-0.0038224	10723	GTEx	DepMap	Descartes	38.64	783.69

Committed Progenitor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Committed Progenitor subcluster (seems to mean progenitor of chromaffin cells), which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.83e-02
Mean rank of genes in gene set: 4620
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MEG3	0.0049870	38	GTEx	DepMap	Descartes	5.32	12.83
UNC5C	0.0046808	44	GTEx	DepMap	Descartes	1.52	9.35
NTRK3	0.0012195	743	GTEx	DepMap	Descartes	0.04	0.09
NRK	0.0006140	1451	GTEx	DepMap	Descartes	0.00	0.00
ZDBF2	0.0004520	1793	GTEx	DepMap	Descartes	0.32	1.53
SYTL4	-0.0001989	4088	GTEx	DepMap	Descartes	0.06	1.20
SLC18A2	-0.0002319	4248	GTEx	DepMap	Descartes	0.04	0.51
PARM1	-0.0003259	4689	GTEx	DepMap	Descartes	0.00	0.00
DGKK	-0.0004250	5076	GTEx	DepMap	Descartes	0.04	0.07
FAM155A	-0.0004780	5262	GTEx	DepMap	Descartes	0.46	2.57
NDUFA4L2	-0.0007131	6083	GTEx	DepMap	Descartes	0.01	0.22
SYT1	-0.0009327	6683	GTEx	DepMap	Descartes	3.40	42.57
RGS4	-0.0015295	8076	GTEx	DepMap	Descartes	5.73	51.74
ATP6V1B2	-0.0022587	9230	GTEx	DepMap	Descartes	0.42	1.47
RGS5	-0.0063788	11796	GTEx	DepMap	Descartes	29.36	155.90

Myocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that MYH3+ Myocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.85e-02
Mean rank of genes in gene set: 1745
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TTN	0.0012992	680	GTEx	DepMap	Descartes	0.09	0.09
MYH3	0.0001133	2810	GTEx	DepMap	Descartes	0.01	0.26

Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.89e-02
Mean rank of genes in gene set: 4504.31
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
MGP	0.0038026	82	GTEx	DepMap	Descartes	6.96	256.79
SPARC	0.0028254	167	GTEx	DepMap	Descartes	2.80	51.95
COL6A2	0.0013888	618	GTEx	DepMap	Descartes	1.07	18.96
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75
LEPR	0.0001757	2580	GTEx	DepMap	Descartes	0.11	0.91
DCN	-0.0008165	6373	GTEx	DepMap	Descartes	0.12	1.45
BGN	-0.0012522	7509	GTEx	DepMap	Descartes	0.29	7.08
CALD1	-0.0018615	8665	GTEx	DepMap	Descartes	9.35	116.45
COL1A1	-0.0019570	8815	GTEx	DepMap	Descartes	4.36	51.78
LUM	-0.0029889	10034	GTEx	DepMap	Descartes	0.46	9.72
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.30

Inflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.52e-02
Mean rank of genes in gene set: 142
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	0.0030492	142	GTEx	DepMap	Descartes	2.74	15.75

Mesenchymal (Kildisiute)
Mesenchymal markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.62e-02
Mean rank of genes in gene set: 177
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0027684	177	GTEx	DepMap	Descartes	0.53	5.82

Muscle progenitor (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PAX7+ Muscle progenitor were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.00e-02
Mean rank of genes in gene set: 2061
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDON	0.0017077	440	GTEx	DepMap	Descartes	0.28	1.72
PAX7	-0.0001033	3682	GTEx	DepMap	Descartes	0.00	0.00

p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.10e-02
Mean rank of genes in gene set: 2087
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0160377	1	GTEx	DepMap	Descartes	70.27	243.50
CDKN1A	-0.0002181	4173	GTEx	DepMap	Descartes	3.33	70.32

Axon guidance (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for axon guidance instead of myelination:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.22e-02
Mean rank of genes in gene set: 391
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SEMA3B	0.001833	391	GTEx	DepMap	Descartes	0.12	2.61

Nerves and neurofiliment (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - NF200 is expressed in neurofiliments and is found close to SCPs in normal tissue, NRG1 is secreted by neurons, to which ERBB3 (on glia) binds.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.89e-02
Mean rank of genes in gene set: 607
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	0.0014035	607	GTEx	DepMap	Descartes	0.74	4.16

Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.12e-02
Mean rank of genes in gene set: 3043.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRB	0.0009787	987	GTEx	DepMap	Descartes	0.13	0.79
KDR	0.0000108	3174	GTEx	DepMap	Descartes	0.00	0.00
PLVAP	-0.0003941	4970	GTEx	DepMap	Descartes	0.00	0.00

Liver Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.01e-02
Mean rank of genes in gene set: 2497
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VTN	0.0046583	46	GTEx	DepMap	Descartes	0.25	8.58
AHSG	-0.0003868	4948	GTEx	DepMap	Descartes	0.00	0.00

Fetal Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Fetal Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.10e-02
Mean rank of genes in gene set: 956
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRAMD1B	0.0010122	956	GTEx	DepMap	Descartes	0.1	0.79

Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.12e-02
Mean rank of genes in gene set: 3618
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRCP	0.0017689	412	GTEx	DepMap	Descartes	0.86	7.35
EGFL7	0.0001522	2662	GTEx	DepMap	Descartes	0.64	17.99
KDR	0.0000108	3174	GTEx	DepMap	Descartes	0.00	0.00
FLT1	-0.0016165	8224	GTEx	DepMap	Descartes	0.00	0.00

Mesenchymal cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that COL1A1+ Mesenchymal were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.47e-02
Mean rank of genes in gene set: 3260
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0027684	177	GTEx	DepMap	Descartes	0.53	5.82
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
COL1A1	-0.0019570	8815	GTEx	DepMap	Descartes	4.36	51.78

Other T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.62e-02
Mean rank of genes in gene set: 4257.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TCF7	0.0001464	2687	GTEx	DepMap	Descartes	0.20	2.00
FOXP3	-0.0000074	3277	GTEx	DepMap	Descartes	0.01	0.11
CD4	-0.0001246	3756	GTEx	DepMap	Descartes	0.00	0.00
LEF1	-0.0002943	4547	GTEx	DepMap	Descartes	0.05	0.51
CCR7	-0.0003799	4927	GTEx	DepMap	Descartes	0.00	0.00
SELL	-0.0008085	6352	GTEx	DepMap	Descartes	0.00	0.00

Normal Schwann cell precurors, but not Neuroblastoma Scps (Olsen)
Based on their neuroblastoma data and stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.78e-02
Mean rank of genes in gene set: 1587
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0005461	1587	GTEx	DepMap	Descartes	0.74	15.88

Hepatocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ALB+ Hepatocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D. The main text also speculated that these hepatocytes were probably derived from neighboring tissue, and hence artifactual, but there is no evidence presented for this.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-02
Mean rank of genes in gene set: 2979
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ASGR1	0.0002043	2504	GTEx	DepMap	Descartes	0.07	1.81
ALB	-0.0000499	3454	GTEx	DepMap	Descartes	0.00	0.00

Schwann cell precursor (Kildisiute)
SCP markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.02e-01
Mean rank of genes in gene set: 3618
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
MPZ	-0.0003477	4804	GTEx	DepMap	Descartes	0.01	0.11

Schwann cell precursors (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.02e-01
Mean rank of genes in gene set: 3618
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
MPZ	-0.0003477	4804	GTEx	DepMap	Descartes	0.01	0.11

Meta_9 ATRX (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.03e-01
Mean rank of genes in gene set: 3031.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ATRX	0.0012637	704	GTEx	DepMap	Descartes	5.75	28.69
ZFHX3	-0.0005028	5359	GTEx	DepMap	Descartes	1.49	3.18

Noninflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.15e-01
Mean rank of genes in gene set: 3195.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAF	0.0004821	1735	GTEx	DepMap	Descartes	0	0
CD163	-0.0003186	4656	GTEx	DepMap	Descartes	0	0

Mesemchymal validated (Olsen)
Stated on pages 7 and 8 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is stated that a mesenchymal-like neuroblastoma cell state is validate by combined immunofluorescence staining for PDGFRA and FISH for PPMID gain, a gene on 17q.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.22e-01
Mean rank of genes in gene set: 2047
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75

Neuroblastoma SCPs but not normal SCPs (Olsen)
The same as above:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.27e-01
Mean rank of genes in gene set: 3353.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB8	0.0014164	594	GTEx	DepMap	Descartes	0.17	1.92
GFRA3	-0.0007263	6113	GTEx	DepMap	Descartes	0.04	0.25

Bridge (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.32e-01
Mean rank of genes in gene set: 3936
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTTNBP2	0.0005062	1688	GTEx	DepMap	Descartes	0.00	0.00
CDH9	-0.0003469	4798	GTEx	DepMap	Descartes	0.00	0.00
ERBB4	-0.0004944	5322	GTEx	DepMap	Descartes	0.04	0.27

Endothelial cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRB+ Endothelial cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.34e-01
Mean rank of genes in gene set: 3957.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRB	0.0009787	987	GTEx	DepMap	Descartes	0.13	0.79
EGFL7	0.0001522	2662	GTEx	DepMap	Descartes	0.64	17.99
FLT1	-0.0016165	8224	GTEx	DepMap	Descartes	0.00	0.00

Bridge region SCP-like (Olsen)
As above but for the SCP-like region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.46e-01
Mean rank of genes in gene set: 4363.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
FXYD1	-0.0000994	3664	GTEx	DepMap	Descartes	0.01	0.33
MPZ	-0.0003477	4804	GTEx	DepMap	Descartes	0.01	0.11
S100B	-0.0007702	6254	GTEx	DepMap	Descartes	0.04	1.17

Pigmentation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, Skin pigmentation genes, identified in melanoma.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.48e-01
Mean rank of genes in gene set: 4380.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MITF	-0.0001167	3727	GTEx	DepMap	Descartes	0.10	1.37
PMEL	-0.0001574	3907	GTEx	DepMap	Descartes	0.01	0.33
MLANA	-0.0002383	4280	GTEx	DepMap	Descartes	0.00	0.00
DCT	-0.0005715	5607	GTEx	DepMap	Descartes	0.00	0.00

Erythroid cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.49e-01
Mean rank of genes in gene set: 2505
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALAS2	0.0002035	2505	GTEx	DepMap	Descartes	0	0

Schwann cell precursor (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being characteristic of Schwann cell lineage and Furlan et al. (Science 2017, PMID 28684471) is referenced to support this. These cell types seem to be claimed to form a bridge between the mesenchymal and adrenergic cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.49e-01
Mean rank of genes in gene set: 4101.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
S100B	-0.0007702	6254	GTEx	DepMap	Descartes	0.04	1.17

Schwann cell precursor-like Fig 1D (Olsen)
Similar to above, but for selected SCP marker genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.49e-01
Mean rank of genes in gene set: 4101.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
S100B	-0.0007702	6254	GTEx	DepMap	Descartes	0.04	1.17

N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.50e-01
Mean rank of genes in gene set: 5335.88
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LGR5	0.0053743	27	GTEx	DepMap	Descartes	0.93	12.63
PCLO	0.0016190	483	GTEx	DepMap	Descartes	0.57	1.91
SLCO3A1	0.0015461	524	GTEx	DepMap	Descartes	0.53	5.59
CACNA2D1	0.0003628	2033	GTEx	DepMap	Descartes	1.12	8.06
PTPRN	0.0003290	2118	GTEx	DepMap	Descartes	0.39	4.50
CXCL14	-0.0001307	3785	GTEx	DepMap	Descartes	0.00	0.00
ADCYAP1R1	-0.0002632	4387	GTEx	DepMap	Descartes	0.04	0.08
SYN2	-0.0004564	5181	GTEx	DepMap	Descartes	0.32	4.23
SCG5	-0.0005587	5565	GTEx	DepMap	Descartes	0.59	27.04
CELF4	-0.0010209	6900	GTEx	DepMap	Descartes	0.09	0.54
PPFIA2	-0.0010608	7004	GTEx	DepMap	Descartes	0.01	0.11
SNAP25	-0.0013202	7655	GTEx	DepMap	Descartes	0.69	12.59
NAP1L5	-0.0019273	8767	GTEx	DepMap	Descartes	0.15	3.23
SCG3	-0.0022401	9205	GTEx	DepMap	Descartes	1.20	10.66
C1QL1	-0.0022609	9231	GTEx	DepMap	Descartes	0.26	16.08
GNAS	-0.0148693	12509	GTEx	DepMap	Descartes	26.09	184.91

Adrenergic (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for adrenergic genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.56e-01
Mean rank of genes in gene set: 3685.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	0.000956	1013	GTEx	DepMap	Descartes	0.15	6.37
DBH	-0.000812	6358	GTEx	DepMap	Descartes	0.39	7.58

Sympathobasts or chromaffin (Kildisiute)
Sympathoblast and chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.58e-01
Mean rank of genes in gene set: 4176.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
CHGB	-0.0004494	5158	GTEx	DepMap	Descartes	1.12	21.58
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58

Endothelium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.85e-01
Mean rank of genes in gene set: 3033
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	4.73e-05	3033	GTEx	DepMap	Descartes	0.01	0.18

Melanocytes (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.87e-01
Mean rank of genes in gene set: 4413.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MITF	-0.0001167	3727	GTEx	DepMap	Descartes	0.10	1.37
PMEL	-0.0001574	3907	GTEx	DepMap	Descartes	0.01	0.33
DCT	-0.0005715	5607	GTEx	DepMap	Descartes	0.00	0.00

Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.90e-01
Mean rank of genes in gene set: 5565.65
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FAM102A	0.0013336	653	GTEx	DepMap	Descartes	0.33	3.72
GJA1	0.0013105	669	GTEx	DepMap	Descartes	0.21	5.62
HES1	0.0011113	845	GTEx	DepMap	Descartes	0.42	17.71
ADAMTS1	0.0009240	1048	GTEx	DepMap	Descartes	0.51	4.44
MCF2L	0.0006499	1394	GTEx	DepMap	Descartes	0.18	0.94
SHROOM2	0.0003327	2107	GTEx	DepMap	Descartes	0.01	0.25
FBLN2	0.0002934	2236	GTEx	DepMap	Descartes	0.15	1.91
JAG1	0.0002433	2379	GTEx	DepMap	Descartes	0.07	0.68
MECOM	0.0001235	2778	GTEx	DepMap	Descartes	0.03	0.50
LFNG	-0.0001446	3858	GTEx	DepMap	Descartes	0.04	0.97
IGFBP3	-0.0004820	5277	GTEx	DepMap	Descartes	1.17	29.03
THBD	-0.0012023	7377	GTEx	DepMap	Descartes	0.00	0.00
SPRY1	-0.0016258	8247	GTEx	DepMap	Descartes	0.23	4.08
RHOB	-0.0021710	9122	GTEx	DepMap	Descartes	0.62	12.84
IVNS1ABP	-0.0022762	9248	GTEx	DepMap	Descartes	0.74	7.03
CLIC4	-0.0022795	9256	GTEx	DepMap	Descartes	0.69	9.40
DUSP6	-0.0026398	9695	GTEx	DepMap	Descartes	0.38	3.87
TM4SF1	-0.0038976	10769	GTEx	DepMap	Descartes	0.43	8.20
CDK1	-0.0068903	11904	GTEx	DepMap	Descartes	0.81	13.67
MARCKSL1	-0.0126642	12451	GTEx	DepMap	Descartes	6.58	135.73

M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.91e-01
Mean rank of genes in gene set: 5078.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL13	0.0001609	2620	GTEx	DepMap	Descartes	0.00	0.00
ARG1	0.0000074	3194	GTEx	DepMap	Descartes	0.00	0.00
IL10	-0.0002084	4125	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002669	4411	GTEx	DepMap	Descartes	0.00	0.00
CD163	-0.0003186	4656	GTEx	DepMap	Descartes	0.00	0.00
VEGFA	-0.0012075	7386	GTEx	DepMap	Descartes	0.41	1.05
TGFB1	-0.0022006	9157	GTEx	DepMap	Descartes	1.24	26.58

Chromaffin (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. These markers are expressed at a lower level in symphathoblasts.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.93e-01
Mean rank of genes in gene set: 4050
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	0.000956	1013	GTEx	DepMap	Descartes	0.15	6.37
CHGA	-0.001092	7087	GTEx	DepMap	Descartes	2.73	64.48

Schwann cell precursors (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.07e-01
Mean rank of genes in gene set: 3317
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-1.51e-05	3317	GTEx	DepMap	Descartes	0	0

Schwann cell precursors (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. The authors data suggest these SCPs can give rise to symphathoblasts, which can then give rise to chromaffin cells. However, these SCPs can also directly give rise to chromaffin cells (i.e there are two bridges/paths).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.07e-01
Mean rank of genes in gene set: 3317
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-1.51e-05	3317	GTEx	DepMap	Descartes	0	0

EMT II (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in HNSCC cell lines:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.21e-01
Mean rank of genes in gene set: 4880.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL5A1	0.0031547	135	GTEx	DepMap	Descartes	0.70	6.77
FN1	0.0021965	274	GTEx	DepMap	Descartes	4.12	37.60
AXL	-0.0016976	8391	GTEx	DepMap	Descartes	0.50	6.81
VIM	-0.0038224	10723	GTEx	DepMap	Descartes	38.64	783.69

Erythrocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that HBA2+ Erythrocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.47e-01
Mean rank of genes in gene set: 3799
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK1	-0.0001332	3799	GTEx	DepMap	Descartes	0.08	0.21

M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.85e-01
Mean rank of genes in gene set: 5745.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD274	0.0037771	83	GTEx	DepMap	Descartes	0.18	3.80
TNFRSF10B	0.0001566	2640	GTEx	DepMap	Descartes	0.49	7.59
ARG1	0.0000074	3194	GTEx	DepMap	Descartes	0.00	0.00
IL10	-0.0002084	4125	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002669	4411	GTEx	DepMap	Descartes	0.00	0.00
NOS2	-0.0003079	4609	GTEx	DepMap	Descartes	0.00	0.00
CD84	-0.0003764	4910	GTEx	DepMap	Descartes	0.00	0.00
STAT3	-0.0004750	5255	GTEx	DepMap	Descartes	1.29	13.71
TNF	-0.0004907	5308	GTEx	DepMap	Descartes	0.00	0.00
IL1B	-0.0006024	5709	GTEx	DepMap	Descartes	0.00	0.00
VEGFA	-0.0012075	7386	GTEx	DepMap	Descartes	0.41	1.05
ARG2	-0.0021904	9141	GTEx	DepMap	Descartes	0.07	0.85
TGFB1	-0.0022006	9157	GTEx	DepMap	Descartes	1.24	26.58
CD36	-0.0029038	9960	GTEx	DepMap	Descartes	0.22	1.28
HIF1A	-0.0032691	10290	GTEx	DepMap	Descartes	2.55	34.46

Cytotoxic T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.90e-01
Mean rank of genes in gene set: 4273
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0	0

Mesenchymal (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being expressed in a group of mesenchymal-like cells (some at least claimed to be neuroblastoma cells) shown in their UMAP representation on Fig. 1D. They reference the two Nature Genetics paper.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.28e-01
Mean rank of genes in gene set: 5466.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75
LEPR	0.0001757	2580	GTEx	DepMap	Descartes	0.11	0.91
DCN	-0.0008165	6373	GTEx	DepMap	Descartes	0.12	1.45
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.30

HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.30e-01
Mean rank of genes in gene set: 5356
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AIF1	0.0004824	1733	GTEx	DepMap	Descartes	0.00	0.00
CD163	-0.0003186	4656	GTEx	DepMap	Descartes	0.00	0.00
RGS10	-0.0026274	9679	GTEx	DepMap	Descartes	0.64	33.38

Schwann cell Precursor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the SCP subcluster, which is part of the Adrenal Medulla cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.33e-01
Mean rank of genes in gene set: 5802.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TTYH1	0.0005719	1536	GTEx	DepMap	Descartes	0.01	0.07
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
PTPRZ1	-0.0000244	3346	GTEx	DepMap	Descartes	0.00	0.00
NGFR	-0.0001377	3818	GTEx	DepMap	Descartes	0.01	0.33
CHL1	-0.0002236	4212	GTEx	DepMap	Descartes	0.02	0.17
DAGLA	-0.0006718	5952	GTEx	DepMap	Descartes	0.07	0.55
CST3	-0.0021133	9046	GTEx	DepMap	Descartes	5.32	87.33
CNP	-0.0022104	9169	GTEx	DepMap	Descartes	0.49	4.00
SERPINE2	-0.0023785	9387	GTEx	DepMap	Descartes	1.27	14.12
LMO4	-0.0048740	11310	GTEx	DepMap	Descartes	0.96	8.38

Myelination (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are state as being involved in Myelination and are expressed in the Schwann cell precursor cluster of their UMAP (Fig. 1D), these are suggested to represent more mature myelinating Schwann cells. MPZ is Myelin Protien Zero.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.60e-01
Mean rank of genes in gene set: 5355.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0003477	4804	GTEx	DepMap	Descartes	0.01	0.11
LGI4	-0.0006598	5907	GTEx	DepMap	Descartes	0.00	0.00

EpiSen (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, an epithelial senescence associated program.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.71e-01
Mean rank of genes in gene set: 5677.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLPI	-0.0000690	3533	GTEx	DepMap	Descartes	0.00	0.00
AQP3	-0.0000934	3638	GTEx	DepMap	Descartes	0.03	0.42
LCN2	-0.0005534	5547	GTEx	DepMap	Descartes	0.00	0.00
CLDN4	-0.0029456	9993	GTEx	DepMap	Descartes	0.04	0.63

Chromaffin cells Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for chromaffin cells (differentiating from symphathoblasts):
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.85e-01
Mean rank of genes in gene set: 5661.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	-0.0003358	4739	GTEx	DepMap	Descartes	0.00	0.00
CHGB	-0.0004494	5158	GTEx	DepMap	Descartes	1.12	21.58
CHGA	-0.0010920	7087	GTEx	DepMap	Descartes	2.73	64.48

IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.03e-01
Mean rank of genes in gene set: 5876
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IFIT3	0.0001693	2599	GTEx	DepMap	Descartes	0.07	1.64
ISG20	-0.0004707	5237	GTEx	DepMap	Descartes	0.03	0.40
IFIT2	-0.0005126	5380	GTEx	DepMap	Descartes	0.01	0.24
IFIT1	-0.0009820	6808	GTEx	DepMap	Descartes	0.04	0.57
ISG15	-0.0023483	9356	GTEx	DepMap	Descartes	0.31	19.45

SCPs neuroblastoma unique (Olsen)
Similar to above, but for genes unique to neuroblastoma SCP-like cells. Note FN1 is often used as a mesenchymal marker gene.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-01
Mean rank of genes in gene set: 6024.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FN1	0.0021965	274	GTEx	DepMap	Descartes	4.12	37.60
ITGB8	0.0014164	594	GTEx	DepMap	Descartes	0.17	1.92
GFRA3	-0.0007263	6113	GTEx	DepMap	Descartes	0.04	0.25
TIMP3	-0.0008481	6457	GTEx	DepMap	Descartes	0.61	8.70
IFITM3	-0.0037337	10664	GTEx	DepMap	Descartes	0.45	36.13
ANXA1	-0.0075910	12046	GTEx	DepMap	Descartes	0.96	23.93

Adrenal cortex (Kildisiute)
Adrenal cortex markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.34e-01
Mean rank of genes in gene set: 5671
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-0.0005892	5671	GTEx	DepMap	Descartes	0	0

Adrenal gland cortex (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.34e-01
Mean rank of genes in gene set: 5671
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-0.0005892	5671	GTEx	DepMap	Descartes	0	0

Chromaffin and connecting progenitor cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.41e-01
Mean rank of genes in gene set: 6005.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58
CHGA	-0.0010920	7087	GTEx	DepMap	Descartes	2.73	64.48
DDC	-0.0025203	9564	GTEx	DepMap	Descartes	0.47	6.69

Late chromaffin cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: this late chromaffin cell signature also includes PNMT, which is an enzyme catalyzing methylation of norepinephrine to form epinephrine; this marker is absent from the ealier less differentiated chromaffin cells (which may have been referred to as sympathoblasts in other datasets, I think):
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.41e-01
Mean rank of genes in gene set: 6005.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58
CHGA	-0.0010920	7087	GTEx	DepMap	Descartes	2.73	64.48
DDC	-0.0025203	9564	GTEx	DepMap	Descartes	0.47	6.69

B cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.47e-01
Mean rank of genes in gene set: 5796
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-0.0006216	5796	GTEx	DepMap	Descartes	0.01	0.04

Pre-E Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Pre Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.62e-01
Mean rank of genes in gene set: 6175
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ARHGEF28	0.0013516	636	GTEx	DepMap	Descartes	0.24	NA
SLC38A4	0.0000235	3120	GTEx	DepMap	Descartes	0.18	2.29
RPS6KA6	-0.0001258	3763	GTEx	DepMap	Descartes	0.22	0.59
SLC31A1	-0.0001398	3829	GTEx	DepMap	Descartes	0.47	4.97
LRP11	-0.0004798	5268	GTEx	DepMap	Descartes	0.41	5.47
ARNT2	-0.0005606	5573	GTEx	DepMap	Descartes	0.14	0.85
FAM163A	-0.0006410	5855	GTEx	DepMap	Descartes	0.11	1.34
PCP4	-0.0013948	7816	GTEx	DepMap	Descartes	0.00	NA
TLE1	-0.0021258	9063	GTEx	DepMap	Descartes	0.55	5.17
TMX4	-0.0022922	9269	GTEx	DepMap	Descartes	2.40	17.96
NELFCD	-0.0026852	9744	GTEx	DepMap	Descartes	0.75	NA
JUN	-0.0031161	10164	GTEx	DepMap	Descartes	2.38	27.40

Subepicardial mesenchyme (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.40e-01
Mean rank of genes in gene set: 6411.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
TBX18	0.0002635	2329	GTEx	DepMap	Descartes	0.09	1.23
COL1A1	-0.0019570	8815	GTEx	DepMap	Descartes	4.36	51.78
TWIST2	-0.0034030	10402	GTEx	DepMap	Descartes	0.04	1.83
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.30
TWIST1	-0.0059114	11669	GTEx	DepMap	Descartes	6.39	164.26

Symphathoadrenal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.89e-01
Mean rank of genes in gene set: 7087
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGA	-0.001092	7087	GTEx	DepMap	Descartes	2.73	64.48

PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.89e-01
Mean rank of genes in gene set: 6478.94
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CSF1	0.0014973	538	GTEx	DepMap	Descartes	0.24	3.42
STAT6	0.0005396	1603	GTEx	DepMap	Descartes	0.01	0.07
TNFRSF10B	0.0001566	2640	GTEx	DepMap	Descartes	0.49	7.59
ARG1	0.0000074	3194	GTEx	DepMap	Descartes	0.00	0.00
PTGS2	-0.0003563	4835	GTEx	DepMap	Descartes	0.01	0.06
CD84	-0.0003764	4910	GTEx	DepMap	Descartes	0.00	0.00
STAT3	-0.0004750	5255	GTEx	DepMap	Descartes	1.29	13.71
IL1B	-0.0006024	5709	GTEx	DepMap	Descartes	0.00	0.00
SLC27A2	-0.0011325	7211	GTEx	DepMap	Descartes	0.01	0.26
IRF1	-0.0014601	7955	GTEx	DepMap	Descartes	0.18	1.94
ARG2	-0.0021904	9141	GTEx	DepMap	Descartes	0.07	0.85
TGFB1	-0.0022006	9157	GTEx	DepMap	Descartes	1.24	26.58
STAT1	-0.0022513	9219	GTEx	DepMap	Descartes	0.78	9.54
CD36	-0.0029038	9960	GTEx	DepMap	Descartes	0.22	1.28
HIF1A	-0.0032691	10290	GTEx	DepMap	Descartes	2.55	34.46
ANXA1	-0.0075910	12046	GTEx	DepMap	Descartes	0.96	23.93

Kidney Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.09e-01
Mean rank of genes in gene set: 7276
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LYPD1	-0.0011591	7276	GTEx	DepMap	Descartes	0.09	1.01

SCPs mouse unique (Olsen)
Selected list of SCP marker genes shown in Fig. 2B of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these genes were unique to mouse SCPs as determined by the linearge tracing study Furlan et al. (Science 2017, PMID 28684471).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.09e-01
Mean rank of genes in gene set: 6776
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	0.0005461	1587	GTEx	DepMap	Descartes	0.74	15.88
SCRG1	0.0002755	2291	GTEx	DepMap	Descartes	0.05	1.09
CRABP1	-0.0039906	10823	GTEx	DepMap	Descartes	0.27	15.97
H1FX	-0.0117193	12403	GTEx	DepMap	Descartes	4.09	NA

Broad sympathetic marker (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.17e-01
Mean rank of genes in gene set: 6716.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
CHGB	-0.0004494	5158	GTEx	DepMap	Descartes	1.12	21.58
HAND2	-0.0007977	6329	GTEx	DepMap	Descartes	8.77	140.99
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58
GATA2	-0.0032622	10279	GTEx	DepMap	Descartes	2.46	23.01
GATA3	-0.0045885	11160	GTEx	DepMap	Descartes	3.52	37.60

Bridge region mesencchymal (Olsen)
Marker genes shown in Fig. 3A of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - Cells were ordered by pseudotime in the bridge region, this first group of cells were from the mesenchymal part of the trajectory.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.23e-01
Mean rank of genes in gene set: 6588.77
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75
PODXL	0.0000204	3132	GTEx	DepMap	Descartes	0.34	3.39
NPNT	-0.0000810	3578	GTEx	DepMap	Descartes	0.00	0.00
MAFF	-0.0003468	4797	GTEx	DepMap	Descartes	0.04	0.98
TNNT2	-0.0011983	7366	GTEx	DepMap	Descartes	0.05	0.55
BGN	-0.0012522	7509	GTEx	DepMap	Descartes	0.29	7.08
MYC	-0.0018553	8660	GTEx	DepMap	Descartes	0.20	2.48
CALD1	-0.0018615	8665	GTEx	DepMap	Descartes	9.35	116.45
KLF4	-0.0020078	8887	GTEx	DepMap	Descartes	0.00	0.00
FGF1	-0.0023291	9324	GTEx	DepMap	Descartes	0.01	0.13
LUM	-0.0029889	10034	GTEx	DepMap	Descartes	0.46	9.72
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.30

Definitive Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Definitive Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.42e-01
Mean rank of genes in gene set: 6932.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GREB1	0.0004196	1877	GTEx	DepMap	Descartes	0.34	2.05
CPE	-0.0009190	6640	GTEx	DepMap	Descartes	0.77	16.23
CALN1	-0.0012263	7442	GTEx	DepMap	Descartes	0.00	0.00
CHCHD10	-0.0062878	11772	GTEx	DepMap	Descartes	2.06	97.10

Immune (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Immune cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.62e-01
Mean rank of genes in gene set: 7348.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCP2	0.0002226	2452	GTEx	DepMap	Descartes	0.01	0.06
TMSB4X	-0.0093676	12245	GTEx	DepMap	Descartes	30.53	826.27

Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.72e-01
Mean rank of genes in gene set: 6886
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALK	0.0003751	1999	GTEx	DepMap	Descartes	0.12	0.52
SYN3	0.0001042	2831	GTEx	DepMap	Descartes	0.00	0.00
IL7	-0.0000313	3375	GTEx	DepMap	Descartes	0.27	6.58
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
NEFM	-0.0042066	10959	GTEx	DepMap	Descartes	1.19	20.05
GAP43	-0.0052463	11447	GTEx	DepMap	Descartes	1.48	12.00

Bridge (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Bridge subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.77e-01
Mean rank of genes in gene set: 6756.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NFASC	0.0006311	1422	GTEx	DepMap	Descartes	0.10	0.97
MIAT	0.0005524	1571	GTEx	DepMap	Descartes	0.28	2.41
TBX20	0.0003022	2208	GTEx	DepMap	Descartes	0.01	0.50
WDR6	0.0002372	2396	GTEx	DepMap	Descartes	0.96	10.97
GSE1	-0.0003660	4877	GTEx	DepMap	Descartes	1.18	NA
DPYSL3	-0.0007065	6058	GTEx	DepMap	Descartes	1.80	15.70
CDKN1C	-0.0012790	7572	GTEx	DepMap	Descartes	0.21	3.88
DLL3	-0.0025580	9604	GTEx	DepMap	Descartes	0.34	5.81
RCC2	-0.0026902	9750	GTEx	DepMap	Descartes	0.93	9.55
SOX11	-0.0042142	10965	GTEx	DepMap	Descartes	1.47	7.64
CKB	-0.0081660	12131	GTEx	DepMap	Descartes	5.31	112.10
LDHB	-0.0154409	12520	GTEx	DepMap	Descartes	10.07	248.54

Late Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: the Jansky Late Neuroblast signature is the same as the earlier Neuroblast signature, but NEFM and ALK are now absent (meaning lower expressed at later stages of differentiation):
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.84e-01
Mean rank of genes in gene set: 7048.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SYN3	0.0001042	2831	GTEx	DepMap	Descartes	0.00	0.00
IL7	-0.0000313	3375	GTEx	DepMap	Descartes	0.27	6.58
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
GAP43	-0.0052463	11447	GTEx	DepMap	Descartes	1.48	12.00

Myofibroblasts (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ACTA2+ Myofibroblasts were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.02e-01
Mean rank of genes in gene set: 7382.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYH11	0.0004940	1714	GTEx	DepMap	Descartes	0.00	0.00
ACTA2	-0.0023770	9384	GTEx	DepMap	Descartes	0.31	12.82
TAGLN	-0.0043604	11049	GTEx	DepMap	Descartes	0.39	8.18

Immune cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRC+ Immune cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.08e-01
Mean rank of genes in gene set: 7676.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD247	-0.0004617	5203	GTEx	DepMap	Descartes	0.01	0.19
PTPRC	-0.0030938	10150	GTEx	DepMap	Descartes	0.00	0.00

Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.29e-01
Mean rank of genes in gene set: 7552.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BCL2	0.0009646	1003	GTEx	DepMap	Descartes	0.35	2.20
NPY	-0.0031660	10207	GTEx	DepMap	Descartes	4.00	412.72
GAP43	-0.0052463	11447	GTEx	DepMap	Descartes	1.48	12.00

Immune cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.54e-01
Mean rank of genes in gene set: 8034
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR4	-0.0006628	5918	GTEx	DepMap	Descartes	0.13	0.87
PTPRC	-0.0030938	10150	GTEx	DepMap	Descartes	0.00	0.00

Mesencchymal populations mouse (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.64e-01
Mean rank of genes in gene set: 8117
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FLI1	-0.0005056	5367	GTEx	DepMap	Descartes	0.01	0.05
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.30

Meta_8 undefined undifferentiated neuronal (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.96e-01
Mean rank of genes in gene set: 8393
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTNNB1	-0.0006308	5821	GTEx	DepMap	Descartes	1.43	12.07
SOX11	-0.0042142	10965	GTEx	DepMap	Descartes	1.47	7.64

Chromaffin cell-like (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.03e-01
Mean rank of genes in gene set: 8454
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0009409	6701	GTEx	DepMap	Descartes	0.08	1.09
NPY	-0.0031660	10207	GTEx	DepMap	Descartes	4.00	412.72

Bridge (Kildisiute)
Bridge cell (cites Furlan 2017) markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.21e-01
Mean rank of genes in gene set: 9604
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DLL3	-0.002558	9604	GTEx	DepMap	Descartes	0.34	5.81

Chromaffin cell development (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.33e-01
Mean rank of genes in gene set: 8744.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HAND2	-0.0007977	6329	GTEx	DepMap	Descartes	8.77	140.99
GATA3	-0.0045885	11160	GTEx	DepMap	Descartes	3.52	37.60

Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.46e-01
Mean rank of genes in gene set: 7199
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EML5	0.0010533	905	GTEx	DepMap	Descartes	1.05	4.01
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
DISP2	0.0001576	2637	GTEx	DepMap	Descartes	0.04	0.07
SLC18A1	-0.0002067	4116	GTEx	DepMap	Descartes	0.46	1.24
CYB561	-0.0002812	4483	GTEx	DepMap	Descartes	1.47	19.24
CHGB	-0.0004494	5158	GTEx	DepMap	Descartes	1.12	21.58
HAND2	-0.0007977	6329	GTEx	DepMap	Descartes	8.77	140.99
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58
CHGA	-0.0010920	7087	GTEx	DepMap	Descartes	2.73	64.48
DDC	-0.0025203	9564	GTEx	DepMap	Descartes	0.47	6.69
MAP1B	-0.0036827	10622	GTEx	DepMap	Descartes	16.34	78.95
PCSK1N	-0.0039098	10777	GTEx	DepMap	Descartes	4.45	116.74
NNAT	-0.0040948	10887	GTEx	DepMap	Descartes	0.22	3.95
GATA3	-0.0045885	11160	GTEx	DepMap	Descartes	3.52	37.60
PHOX2A	-0.0057877	11636	GTEx	DepMap	Descartes	7.52	144.19
UCHL1	-0.0127056	12452	GTEx	DepMap	Descartes	6.96	188.09

Meta_7 undefined sympathetic (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.52e-01
Mean rank of genes in gene set: 8462.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58
CHGA	-0.0010920	7087	GTEx	DepMap	Descartes	2.73	64.48
TUBB2A	-0.0070739	11942	GTEx	DepMap	Descartes	0.83	14.05

Leukocyte (Kildisiute)
Leukocyes markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.58e-01
Mean rank of genes in gene set: 10150
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.0030938	10150	GTEx	DepMap	Descartes	0	0

Adrenergic mature (olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These markers are specific to the mature adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.63e-01
Mean rank of genes in gene set: 9074
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0009409	6701	GTEx	DepMap	Descartes	0.08	1.09
GAP43	-0.0052463	11447	GTEx	DepMap	Descartes	1.48	12.00

Stress response (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.88e-01
Mean rank of genes in gene set: 8813
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOS	-0.0007384	6147	GTEx	DepMap	Descartes	1.75	52.11
JUNB	-0.0030709	10128	GTEx	DepMap	Descartes	0.87	22.49
JUN	-0.0031161	10164	GTEx	DepMap	Descartes	2.38	27.40

Mixed phenotype identified at the fate split point mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells. markers are of the split point where SCPs differentiate.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.98e-01
Mean rank of genes in gene set: 10867
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.3

Adrenergic immature (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These is a marker listed for the immature adrenergic cells. SOX11 is referenced as important in early phases of pro-adrenergic differentiation (cites PMID 20147379) whereas SOX4 appears later. SOX11 is also associated with poor outcome in neuroblatoma bulk RNA-seq data (Olsen analysis).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.02e-01
Mean rank of genes in gene set: 10965
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOX11	-0.0042142	10965	GTEx	DepMap	Descartes	1.47	7.64

Chromaffin Cells (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: the neuronal markers NPY, PRPH, NTRK1 and ISL1 are used to annotate chromaffin cells; these were clearly expressed in neuroblasts in our analyses.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.11e-01
Mean rank of genes in gene set: 9091
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0009409	6701	GTEx	DepMap	Descartes	0.08	1.09
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
PHOX2A	-0.0057877	11636	GTEx	DepMap	Descartes	7.52	144.19

Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.13e-01
Mean rank of genes in gene set: 9752
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
EZH2	-0.0038472	10740	GTEx	DepMap	Descartes	0.82	10.05

Adrenergic neuroblatoma (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - neuroblastoma adrenergic markers derived from their data, which are state as resembling sympathoblasts and lacking chromffin markers such as PNMT:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.23e-01
Mean rank of genes in gene set: 11447
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	-0.0052463	11447	GTEx	DepMap	Descartes	1.48	12

Meta5 unclear (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 10571.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
STMN1	-0.0136868	12488	GTEx	DepMap	Descartes	9.96	94.98

Stress response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 9006.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ATF3	-0.0012430	7479	GTEx	DepMap	Descartes	0.09	2.33
DDIT3	-0.0013792	7782	GTEx	DepMap	Descartes	0.83	42.96
GADD45B	-0.0016294	8260	GTEx	DepMap	Descartes	0.12	3.72
SQSTM1	-0.0032699	10291	GTEx	DepMap	Descartes	3.39	62.40
GADD45A	-0.0047059	11221	GTEx	DepMap	Descartes	1.50	44.25

Symphathoblasts Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for symphathoblasts (differentiating from SCPs):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 9079.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HAND2	-0.0007977	6329	GTEx	DepMap	Descartes	8.77	140.99
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
ELAVL2	-0.0038239	10725	GTEx	DepMap	Descartes	0.34	2.10
ELAVL4	-0.0038660	10752	GTEx	DepMap	Descartes	3.98	27.63

Angioblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Angioblast subcluster of Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-01
Mean rank of genes in gene set: 10088.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PREX1	-0.0013469	7713	GTEx	DepMap	Descartes	0.09	0.58
MAP4K4	-0.0043859	11063	GTEx	DepMap	Descartes	2.16	11.99
NES	-0.0053448	11489	GTEx	DepMap	Descartes	2.23	10.10

Antigen Presenting CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain antigen presenting specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.68e-01
Mean rank of genes in gene set: 8207
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
UPK3B	0.0004756	1744	GTEx	DepMap	Descartes	0.01	0.37
SLPI	-0.0000690	3533	GTEx	DepMap	Descartes	0.00	0.00
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0.00	0.00
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0.00	0.00
CD83	-0.0006681	5934	GTEx	DepMap	Descartes	0.02	0.40
KRT19	-0.0026328	9685	GTEx	DepMap	Descartes	0.11	4.32
KRT8	-0.0031807	10225	GTEx	DepMap	Descartes	0.60	12.68
S100A13	-0.0042247	10973	GTEx	DepMap	Descartes	0.48	8.97
S100A3	-0.0053456	11490	GTEx	DepMap	Descartes	0.07	4.47
S100A4	-0.0056694	11596	GTEx	DepMap	Descartes	0.48	31.59
KRT18	-0.0070572	11936	GTEx	DepMap	Descartes	3.67	99.27
S100A10	-0.0105335	12337	GTEx	DepMap	Descartes	4.91	354.22

E Chromaffin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.74e-01
Mean rank of genes in gene set: 9156.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RAB3B	-0.0009287	6663	GTEx	DepMap	Descartes	0.36	1.99
ANK3	-0.0016477	8292	GTEx	DepMap	Descartes	0.42	1.62
RAB3C	-0.0023236	9316	GTEx	DepMap	Descartes	0.17	1.03
DLK1	-0.0031351	10182	GTEx	DepMap	Descartes	5.14	31.81
NPY	-0.0031660	10207	GTEx	DepMap	Descartes	4.00	412.72
GATA2	-0.0032622	10279	GTEx	DepMap	Descartes	2.46	23.01

Symphathoblasts (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. Several of these markers are also (more weakly) expressed in chromaffin cells. The authors data suggest Symphthoblasts give rise to chromaffin cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.78e-01
Mean rank of genes in gene set: 9908.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
ELAVL4	-0.0038660	10752	GTEx	DepMap	Descartes	3.98	27.63
ELAVL3	-0.0048360	11290	GTEx	DepMap	Descartes	1.22	4.73

Neuroblastoma (Kildisiute)
Neuroblastoma markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.80e-01
Mean rank of genes in gene set: 11561
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYCN	-0.0053347	11486	GTEx	DepMap	Descartes	2.94	45.91
PHOX2A	-0.0057877	11636	GTEx	DepMap	Descartes	7.52	144.19

Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.80e-01
Mean rank of genes in gene set: 8528.36
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	0.0014035	607	GTEx	DepMap	Descartes	0.74	4.16
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
DBH	-0.0008120	6358	GTEx	DepMap	Descartes	0.39	7.58
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
RTN1	-0.0032690	10288	GTEx	DepMap	Descartes	0.96	5.39
MAP1B	-0.0036827	10622	GTEx	DepMap	Descartes	16.34	78.95
ELAVL4	-0.0038660	10752	GTEx	DepMap	Descartes	3.98	27.63
RGS5	-0.0063788	11796	GTEx	DepMap	Descartes	29.36	155.90
MLLT11	-0.0104489	12333	GTEx	DepMap	Descartes	3.59	39.31
UCHL1	-0.0127056	12452	GTEx	DepMap	Descartes	6.96	188.09

Cell cycle (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.82e-01
Mean rank of genes in gene set: 10677.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16
PCNA	-0.0063475	11790	GTEx	DepMap	Descartes	1.38	27.80

Bridge region adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 10928
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
RGS5	-0.0063788	11796	GTEx	DepMap	Descartes	29.36	155.90
MLLT11	-0.0104489	12333	GTEx	DepMap	Descartes	3.59	39.31

Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 11295
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IFITM3	-0.0037337	10664	GTEx	DepMap	Descartes	0.45	36.13
B2M	-0.0040878	10884	GTEx	DepMap	Descartes	9.39	221.96
S100A10	-0.0105335	12337	GTEx	DepMap	Descartes	4.91	354.22

EMT I melanoma (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was melanoma specific.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.94e-01
Mean rank of genes in gene set: 11528
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RRAS	-0.0045149	11127	GTEx	DepMap	Descartes	0.69	34.22
CAV1	-0.0050626	11371	GTEx	DepMap	Descartes	1.25	20.75
TPM1	-0.0078902	12086	GTEx	DepMap	Descartes	11.92	159.35

Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 11112.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16
CDK1	-0.0068903	11904	GTEx	DepMap	Descartes	0.81	13.67
UBE2C	-0.0100796	12305	GTEx	DepMap	Descartes	1.46	59.95

Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 11897.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EIF3L	-0.0057690	11629	GTEx	DepMap	Descartes	4.47	48.06
EIF3F	-0.0073992	12015	GTEx	DepMap	Descartes	4.78	22.62
EIF3E	-0.0076480	12049	GTEx	DepMap	Descartes	4.87	67.50

Bridge region SCP-adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP-adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12249.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MDK	-0.0063159	11782	GTEx	DepMap	Descartes	15.34	526.93
PCBP2	-0.0088572	12197	GTEx	DepMap	Descartes	5.82	62.99
SRP14	-0.0135131	12485	GTEx	DepMap	Descartes	11.95	420.65
HMGB1	-0.0175402	12535	GTEx	DepMap	Descartes	18.18	91.36

Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12325.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TK1	-0.0070374	11931	GTEx	DepMap	Descartes	0.50	11.34
MIF	-0.0101990	12317	GTEx	DepMap	Descartes	18.20	517.68
NPM1	-0.0159487	12525	GTEx	DepMap	Descartes	18.02	454.09
TPI1	-0.0169303	12530	GTEx	DepMap	Descartes	8.46	182.65

Proteasomal degradation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this is for proteasomal degradataion:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12165.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PSMC2	-0.0061130	11728	GTEx	DepMap	Descartes	1.17	19.23
PSME2	-0.0076597	12051	GTEx	DepMap	Descartes	1.73	29.49
PSMA3	-0.0097547	12281	GTEx	DepMap	Descartes	1.66	59.62
PSMA4	-0.0106725	12345	GTEx	DepMap	Descartes	2.40	22.73
PSMB3	-0.0120586	12423	GTEx	DepMap	Descartes	2.68	147.85

Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10930
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
RTN1	-0.0032690	10288	GTEx	DepMap	Descartes	0.96	5.39
ELAVL4	-0.0038660	10752	GTEx	DepMap	Descartes	3.98	27.63
NEFL	-0.0041530	10918	GTEx	DepMap	Descartes	1.07	12.57
NEFM	-0.0042066	10959	GTEx	DepMap	Descartes	1.19	20.05
ELAVL3	-0.0048360	11290	GTEx	DepMap	Descartes	1.22	4.73
INA	-0.0055345	11560	GTEx	DepMap	Descartes	0.64	4.86
CCND1	-0.0079682	12100	GTEx	DepMap	Descartes	8.07	55.34
BASP1	-0.0098051	12284	GTEx	DepMap	Descartes	2.30	43.48
STMN1	-0.0136868	12488	GTEx	DepMap	Descartes	9.96	94.98

Plasmacytoid dendritic cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Adrenal Cortex (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Symphatoblasts (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: Sympathoblasts were identified by Dong et al.28 based on the expression of CARTPT and INSM1, which we found expressed in chromaffin cells:
Autonomic neurons mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Erythroblast (Kildisiute)
Erythroblast markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Chromaffin (Kildisiute)
Chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Cortex (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for their broad Cortex group, which is composed of Fetal Zone, Definitive Zone and Adr Primordium subclusters:
Adrenal cortical (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that CYP11A1+ Adrenal cortical cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:

Below shows ranks on this GEP for literature curated gene lists for large gene sets
These include those reported as mesenchymal/adrenergic by Van Groningen et al.
High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8067.2
Median rank of genes in gene set: 8994
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
SYT4	0.0075257	10	GTEx	DepMap	Descartes	5.05	73.42
ADAM22	0.0057910	22	GTEx	DepMap	Descartes	1.44	8.40
SLIT3	0.0033737	114	GTEx	DepMap	Descartes	2.99	17.43
SYNPO2	0.0033574	118	GTEx	DepMap	Descartes	4.10	13.72
NRCAM	0.0023748	233	GTEx	DepMap	Descartes	0.80	4.95
STRA6	0.0020276	312	GTEx	DepMap	Descartes	0.28	8.71
KIDINS220	0.0019179	363	GTEx	DepMap	Descartes	2.13	12.39
RET	0.0018244	394	GTEx	DepMap	Descartes	0.72	7.60
THSD7A	0.0017908	406	GTEx	DepMap	Descartes	0.91	2.93
RIMBP2	0.0016594	459	GTEx	DepMap	Descartes	0.27	2.76
EML6	0.0016448	471	GTEx	DepMap	Descartes	0.16	1.20
NCAM1	0.0014941	545	GTEx	DepMap	Descartes	0.99	7.49
RNF150	0.0013864	620	GTEx	DepMap	Descartes	0.88	4.16
PRSS12	0.0011240	832	GTEx	DepMap	Descartes	1.49	18.34
RBMS3	0.0010635	897	GTEx	DepMap	Descartes	2.62	15.07
KIF5C	0.0010192	946	GTEx	DepMap	Descartes	1.35	5.20
RPS6KA2	0.0010036	961	GTEx	DepMap	Descartes	0.83	6.43
TH	0.0009560	1013	GTEx	DepMap	Descartes	0.15	6.37
DIABLO	0.0009493	1020	GTEx	DepMap	Descartes	0.16	3.55
ABCA3	0.0006531	1390	GTEx	DepMap	Descartes	0.24	2.14
SV2C	0.0005860	1507	GTEx	DepMap	Descartes	0.19	0.70
ANK2	0.0005690	1542	GTEx	DepMap	Descartes	0.41	1.58
MIAT	0.0005524	1571	GTEx	DepMap	Descartes	0.28	2.41
MAGI3	0.0005309	1624	GTEx	DepMap	Descartes	0.96	6.37
SCN3A	0.0005065	1685	GTEx	DepMap	Descartes	0.15	0.92
AUTS2	0.0004807	1737	GTEx	DepMap	Descartes	0.77	4.89
BMPR1B	0.0004180	1882	GTEx	DepMap	Descartes	0.35	2.49
CACNA2D2	0.0004073	1912	GTEx	DepMap	Descartes	0.19	1.37
ALK	0.0003751	1999	GTEx	DepMap	Descartes	0.12	0.52
CADM1	0.0003747	2001	GTEx	DepMap	Descartes	1.06	6.11

VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.05e-07
Mean rank of genes in gene set: 5423.76
Median rank of genes in gene set: 5462
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
FBN1	0.0108167	2	GTEx	DepMap	Descartes	3.31	20.87
PXDN	0.0091903	6	GTEx	DepMap	Descartes	3.41	31.36
LAMB1	0.0089770	7	GTEx	DepMap	Descartes	3.00	38.98
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
MRC2	0.0073489	12	GTEx	DepMap	Descartes	1.36	15.79
TPBG	0.0070279	14	GTEx	DepMap	Descartes	2.52	26.26
SEMA3C	0.0068156	16	GTEx	DepMap	Descartes	1.80	26.81
EMILIN1	0.0060039	19	GTEx	DepMap	Descartes	2.75	46.25
LTBP1	0.0055519	24	GTEx	DepMap	Descartes	1.82	20.51
FSTL1	0.0051975	35	GTEx	DepMap	Descartes	1.85	22.71
APOE	0.0050132	37	GTEx	DepMap	Descartes	4.08	209.02
NRP1	0.0046235	48	GTEx	DepMap	Descartes	1.30	14.92
IGF2R	0.0044457	55	GTEx	DepMap	Descartes	1.58	7.38
LRRC17	0.0044349	56	GTEx	DepMap	Descartes	4.19	125.49
ATP2B4	0.0042753	60	GTEx	DepMap	Descartes	1.64	12.14
LRP10	0.0041779	64	GTEx	DepMap	Descartes	1.49	12.87
RRBP1	0.0040901	68	GTEx	DepMap	Descartes	1.73	24.02
IL13RA1	0.0040831	69	GTEx	DepMap	Descartes	0.61	9.43
SLC38A2	0.0040549	71	GTEx	DepMap	Descartes	2.26	32.75
GNS	0.0038174	80	GTEx	DepMap	Descartes	1.00	13.15
MGP	0.0038026	82	GTEx	DepMap	Descartes	6.96	256.79
GRN	0.0037026	90	GTEx	DepMap	Descartes	3.05	90.95
TNC	0.0036756	93	GTEx	DepMap	Descartes	0.97	6.90
PDIA3	0.0035822	100	GTEx	DepMap	Descartes	5.11	88.71
NOTCH2	0.0035344	105	GTEx	DepMap	Descartes	0.39	2.53
MAML2	0.0034097	110	GTEx	DepMap	Descartes	0.73	7.29
LAMC1	0.0034079	111	GTEx	DepMap	Descartes	1.41	12.67
APP	0.0033814	113	GTEx	DepMap	Descartes	3.17	52.01
COL11A1	0.0033579	117	GTEx	DepMap	Descartes	0.07	0.74
PLEKHH2	0.0032741	123	GTEx	DepMap	Descartes	0.12	1.42

Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.37e-03
Mean rank of genes in gene set: 4857.64
Median rank of genes in gene set: 4619.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CLU	0.0053231	29	GTEx	DepMap	Descartes	4.04	93.42
TM7SF2	0.0053045	30	GTEx	DepMap	Descartes	2.11	55.21
IGF1R	0.0036120	97	GTEx	DepMap	Descartes	0.90	4.67
NPC1	0.0015199	530	GTEx	DepMap	Descartes	0.16	2.03
POR	0.0010723	884	GTEx	DepMap	Descartes	0.65	14.34
GRAMD1B	0.0010122	956	GTEx	DepMap	Descartes	0.10	0.79
LDLR	0.0009176	1055	GTEx	DepMap	Descartes	0.39	5.47
SCAP	0.0006197	1440	GTEx	DepMap	Descartes	0.54	6.70
SCARB1	0.0003144	2168	GTEx	DepMap	Descartes	0.40	4.07
DHCR7	0.0001540	2652	GTEx	DepMap	Descartes	0.23	4.80
DNER	0.0000397	3053	GTEx	DepMap	Descartes	0.07	0.89
HMGCR	0.0000023	3219	GTEx	DepMap	Descartes	0.54	5.87
PDE10A	-0.0000023	3249	GTEx	DepMap	Descartes	0.07	0.64
ERN1	-0.0000126	3301	GTEx	DepMap	Descartes	0.08	0.59
FREM2	-0.0000514	3460	GTEx	DepMap	Descartes	0.00	0.00
SGCZ	-0.0000589	3487	GTEx	DepMap	Descartes	0.00	0.00
INHA	-0.0000682	3530	GTEx	DepMap	Descartes	0.01	0.26
FRMD5	-0.0001783	3989	GTEx	DepMap	Descartes	0.18	2.13
MSMO1	-0.0004741	5250	GTEx	DepMap	Descartes	0.61	12.32
SLC1A2	-0.0004765	5261	GTEx	DepMap	Descartes	0.00	0.00
SLC16A9	-0.0004874	5296	GTEx	DepMap	Descartes	0.21	2.49
STAR	-0.0005892	5671	GTEx	DepMap	Descartes	0.00	0.00
PEG3	-0.0005904	5676	GTEx	DepMap	Descartes	0.05	NA
SH3PXD2B	-0.0006682	5936	GTEx	DepMap	Descartes	0.31	2.05
PAPSS2	-0.0009183	6637	GTEx	DepMap	Descartes	0.68	9.82
FDXR	-0.0010374	6944	GTEx	DepMap	Descartes	0.97	18.76
HMGCS1	-0.0010555	6986	GTEx	DepMap	Descartes	0.50	5.87
SH3BP5	-0.0010881	7073	GTEx	DepMap	Descartes	0.68	9.26
APOC1	-0.0013652	7751	GTEx	DepMap	Descartes	0.14	15.47
DHCR24	-0.0013742	7773	GTEx	DepMap	Descartes	0.65	4.21

Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.69e-01
Mean rank of genes in gene set: 7326.83
Median rank of genes in gene set: 6718
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
PLXNA4	0.0033847	112	GTEx	DepMap	Descartes	0.48	2.36
SYNPO2	0.0033574	118	GTEx	DepMap	Descartes	4.10	13.72
SLC44A5	0.0013069	671	GTEx	DepMap	Descartes	0.23	3.25
SLC6A2	0.0012717	698	GTEx	DepMap	Descartes	0.91	6.89
ALK	0.0003751	1999	GTEx	DepMap	Descartes	0.12	0.52
IL7	-0.0000313	3375	GTEx	DepMap	Descartes	0.27	6.58
TMEM132C	-0.0002197	4181	GTEx	DepMap	Descartes	0.00	0.00
HS3ST5	-0.0002222	4204	GTEx	DepMap	Descartes	0.11	1.70
EPHA6	-0.0002343	4257	GTEx	DepMap	Descartes	0.01	0.01
FAT3	-0.0002596	4374	GTEx	DepMap	Descartes	0.01	0.03
PTCHD1	-0.0003497	4812	GTEx	DepMap	Descartes	0.01	0.07
EYA4	-0.0004379	5119	GTEx	DepMap	Descartes	0.12	0.36
RGMB	-0.0004396	5125	GTEx	DepMap	Descartes	0.22	3.77
CNKSR2	-0.0004693	5231	GTEx	DepMap	Descartes	0.09	0.66
ANKFN1	-0.0007528	6207	GTEx	DepMap	Descartes	0.00	0.00
TMEFF2	-0.0007748	6264	GTEx	DepMap	Descartes	0.04	0.93
RYR2	-0.0008034	6341	GTEx	DepMap	Descartes	0.01	0.04
RBFOX1	-0.0008325	6420	GTEx	DepMap	Descartes	0.06	0.14
GREM1	-0.0008765	6532	GTEx	DepMap	Descartes	0.24	0.98
NTRK1	-0.0009409	6701	GTEx	DepMap	Descartes	0.08	1.09
RPH3A	-0.0009466	6718	GTEx	DepMap	Descartes	0.34	1.64
REEP1	-0.0010630	7009	GTEx	DepMap	Descartes	0.02	0.15
KCNB2	-0.0014628	7962	GTEx	DepMap	Descartes	0.00	0.00
STMN2	-0.0018544	8655	GTEx	DepMap	Descartes	15.12	209.79
ISL1	-0.0020382	8936	GTEx	DepMap	Descartes	1.78	31.26
EYA1	-0.0022154	9173	GTEx	DepMap	Descartes	0.29	1.43
CNTFR	-0.0023176	9303	GTEx	DepMap	Descartes	0.59	8.13
MARCH11	-0.0028205	9888	GTEx	DepMap	Descartes	1.01	NA
NPY	-0.0031660	10207	GTEx	DepMap	Descartes	4.00	412.72
MAP1B	-0.0036827	10622	GTEx	DepMap	Descartes	16.34	78.95

Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.84e-04
Mean rank of genes in gene set: 4396.5
Median rank of genes in gene set: 3962
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
SLCO2A1	0.0014010	608	GTEx	DepMap	Descartes	0.02	0.31
CHRM3	0.0012022	757	GTEx	DepMap	Descartes	0.59	1.80
CEACAM1	0.0011343	824	GTEx	DepMap	Descartes	0.01	0.19
PTPRB	0.0009787	987	GTEx	DepMap	Descartes	0.13	0.79
EHD3	0.0007445	1250	GTEx	DepMap	Descartes	0.35	4.01
CLDN5	0.0005517	1574	GTEx	DepMap	Descartes	0.01	0.02
CYP26B1	0.0003239	2136	GTEx	DepMap	Descartes	0.00	0.00
MMRN2	0.0002868	2256	GTEx	DepMap	Descartes	0.01	0.17
TEK	0.0001253	2775	GTEx	DepMap	Descartes	0.01	0.01
ROBO4	0.0000811	2922	GTEx	DepMap	Descartes	0.00	0.00
FLT4	0.0000610	2995	GTEx	DepMap	Descartes	0.00	0.00
PODXL	0.0000204	3132	GTEx	DepMap	Descartes	0.34	3.39
MYRIP	0.0000130	3164	GTEx	DepMap	Descartes	0.28	2.70
KDR	0.0000108	3174	GTEx	DepMap	Descartes	0.00	0.00
SHANK3	-0.0000316	3378	GTEx	DepMap	Descartes	0.02	0.12
CDH5	-0.0000342	3397	GTEx	DepMap	Descartes	0.00	0.00
KANK3	-0.0000665	3522	GTEx	DepMap	Descartes	0.00	0.00
NR5A2	-0.0000999	3667	GTEx	DepMap	Descartes	0.00	0.00
BTNL9	-0.0001599	3918	GTEx	DepMap	Descartes	0.00	0.00
TMEM88	-0.0001828	4006	GTEx	DepMap	Descartes	0.04	1.92
GALNT15	-0.0001927	4064	GTEx	DepMap	Descartes	0.01	NA
TIE1	-0.0002039	4108	GTEx	DepMap	Descartes	0.00	0.00
F8	-0.0002104	4134	GTEx	DepMap	Descartes	0.04	0.25
SHE	-0.0002533	4352	GTEx	DepMap	Descartes	0.00	0.00
RASIP1	-0.0002897	4527	GTEx	DepMap	Descartes	0.00	0.00
CALCRL	-0.0003301	4713	GTEx	DepMap	Descartes	0.00	0.00
CRHBP	-0.0003304	4716	GTEx	DepMap	Descartes	0.00	0.00
PLVAP	-0.0003941	4970	GTEx	DepMap	Descartes	0.00	0.00
CDH13	-0.0004499	5160	GTEx	DepMap	Descartes	0.19	1.68
EFNB2	-0.0006335	5833	GTEx	DepMap	Descartes	0.55	3.72

Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.05e-07
Mean rank of genes in gene set: 3555.7
Median rank of genes in gene set: 3395.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
COL3A1	0.0074350	11	GTEx	DepMap	Descartes	7.28	101.15
PCOLCE	0.0073031	13	GTEx	DepMap	Descartes	9.00	301.77
C7	0.0058403	21	GTEx	DepMap	Descartes	3.97	36.83
LRRC17	0.0044349	56	GTEx	DepMap	Descartes	4.19	125.49
MGP	0.0038026	82	GTEx	DepMap	Descartes	6.96	256.79
FREM1	0.0021872	279	GTEx	DepMap	Descartes	0.08	0.34
COL6A3	0.0020674	305	GTEx	DepMap	Descartes	0.12	1.71
ISLR	0.0018101	401	GTEx	DepMap	Descartes	0.04	0.82
PAMR1	0.0015103	533	GTEx	DepMap	Descartes	0.01	0.33
COL27A1	0.0014662	562	GTEx	DepMap	Descartes	0.06	0.82
PCDH18	0.0013390	645	GTEx	DepMap	Descartes	0.26	3.17
EDNRA	0.0012639	703	GTEx	DepMap	Descartes	0.16	1.63
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
CDH11	0.0008104	1171	GTEx	DepMap	Descartes	0.77	7.28
DKK2	0.0007413	1252	GTEx	DepMap	Descartes	0.82	10.01
POSTN	0.0005461	1587	GTEx	DepMap	Descartes	0.74	15.88
OGN	0.0005311	1622	GTEx	DepMap	Descartes	0.00	0.00
ELN	0.0003744	2004	GTEx	DepMap	Descartes	0.07	1.45
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75
LAMC3	0.0002903	2245	GTEx	DepMap	Descartes	0.00	0.00
CLDN11	0.0000753	2947	GTEx	DepMap	Descartes	0.02	0.59
HHIP	0.0000276	3096	GTEx	DepMap	Descartes	0.15	1.70
BICC1	-0.0001059	3695	GTEx	DepMap	Descartes	0.26	1.96
ADAMTS2	-0.0001841	4014	GTEx	DepMap	Descartes	0.11	0.13
GAS2	-0.0002168	4169	GTEx	DepMap	Descartes	0.04	0.97
ABCC9	-0.0002212	4196	GTEx	DepMap	Descartes	0.03	0.15
SCARA5	-0.0002215	4198	GTEx	DepMap	Descartes	0.00	0.00
CD248	-0.0003070	4603	GTEx	DepMap	Descartes	0.20	3.52
SFRP2	-0.0003349	4735	GTEx	DepMap	Descartes	0.00	0.00
ITGA11	-0.0004038	5000	GTEx	DepMap	Descartes	0.01	0.07

Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.19e-04
Mean rank of genes in gene set: 4427.13
Median rank of genes in gene set: 4290.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
FGF14	0.0027902	172	GTEx	DepMap	Descartes	1.05	3.96
GRM7	0.0018250	392	GTEx	DepMap	Descartes	0.10	0.84
EML6	0.0016448	471	GTEx	DepMap	Descartes	0.16	1.20
KCTD16	0.0016293	481	GTEx	DepMap	Descartes	0.26	0.96
CNTN3	0.0009896	978	GTEx	DepMap	Descartes	0.02	0.20
AGBL4	0.0006642	1374	GTEx	DepMap	Descartes	0.04	0.79
CCSER1	0.0004682	1761	GTEx	DepMap	Descartes	0.07	NA
UNC80	0.0004130	1898	GTEx	DepMap	Descartes	0.17	0.57
PACRG	0.0003737	2007	GTEx	DepMap	Descartes	0.05	2.20
TBX20	0.0003022	2208	GTEx	DepMap	Descartes	0.01	0.50
PCSK2	0.0002545	2351	GTEx	DepMap	Descartes	0.00	0.00
SORCS3	0.0001447	2697	GTEx	DepMap	Descartes	0.00	0.00
LAMA3	0.0001333	2744	GTEx	DepMap	Descartes	0.01	0.02
NTNG1	0.0000746	2949	GTEx	DepMap	Descartes	0.25	1.24
SLC24A2	-0.0000078	3280	GTEx	DepMap	Descartes	0.00	0.00
KSR2	-0.0000772	3563	GTEx	DepMap	Descartes	0.01	0.03
CDH18	-0.0001111	3711	GTEx	DepMap	Descartes	0.09	0.67
CDH12	-0.0001833	4008	GTEx	DepMap	Descartes	0.00	0.00
SLC18A1	-0.0002067	4116	GTEx	DepMap	Descartes	0.46	1.24
ROBO1	-0.0002780	4465	GTEx	DepMap	Descartes	0.28	1.97
PENK	-0.0003358	4739	GTEx	DepMap	Descartes	0.00	0.00
DGKK	-0.0004250	5076	GTEx	DepMap	Descartes	0.04	0.07
CHGB	-0.0004494	5158	GTEx	DepMap	Descartes	1.12	21.58
FAM155A	-0.0004780	5262	GTEx	DepMap	Descartes	0.46	2.57
TIAM1	-0.0005409	5486	GTEx	DepMap	Descartes	0.24	1.28
GALNTL6	-0.0005977	5700	GTEx	DepMap	Descartes	0.03	0.05
SLC35F3	-0.0006081	5740	GTEx	DepMap	Descartes	0.03	0.38
ARC	-0.0006161	5772	GTEx	DepMap	Descartes	0.13	1.38
TENM1	-0.0007477	6181	GTEx	DepMap	Descartes	0.00	NA
GRID2	-0.0007975	6326	GTEx	DepMap	Descartes	0.03	0.48

Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.08e-01
Mean rank of genes in gene set: 5937.34
Median rank of genes in gene set: 6123
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
SLC4A1	0.0018204	397	GTEx	DepMap	Descartes	0.01	0.13
SPECC1	0.0015287	527	GTEx	DepMap	Descartes	0.65	6.06
SOX6	0.0003561	2046	GTEx	DepMap	Descartes	0.18	0.67
RAPGEF2	0.0002839	2270	GTEx	DepMap	Descartes	0.50	3.16
ALAS2	0.0002035	2505	GTEx	DepMap	Descartes	0.00	0.00
SLC25A37	0.0002000	2516	GTEx	DepMap	Descartes	0.79	9.77
RHD	0.0000858	2903	GTEx	DepMap	Descartes	0.00	0.00
TFR2	0.0000651	2979	GTEx	DepMap	Descartes	0.04	0.36
ANK1	-0.0001332	3799	GTEx	DepMap	Descartes	0.08	0.21
GYPC	-0.0001992	4090	GTEx	DepMap	Descartes	0.00	0.00
RGS6	-0.0003884	4952	GTEx	DepMap	Descartes	0.00	0.00
SPTB	-0.0003967	4980	GTEx	DepMap	Descartes	0.01	0.06
CPOX	-0.0006273	5809	GTEx	DepMap	Descartes	0.12	1.93
DENND4A	-0.0007193	6094	GTEx	DepMap	Descartes	0.23	1.82
SLC25A21	-0.0007303	6123	GTEx	DepMap	Descartes	0.01	0.07
TMCC2	-0.0007629	6237	GTEx	DepMap	Descartes	0.02	0.11
ABCB10	-0.0008156	6371	GTEx	DepMap	Descartes	0.15	1.31
TRAK2	-0.0009415	6703	GTEx	DepMap	Descartes	0.47	4.13
GCLC	-0.0010904	7083	GTEx	DepMap	Descartes	0.24	2.41
SELENBP1	-0.0010962	7100	GTEx	DepMap	Descartes	0.00	0.00
FECH	-0.0014823	7989	GTEx	DepMap	Descartes	0.16	0.77
MARCH3	-0.0015281	8072	GTEx	DepMap	Descartes	0.17	NA
XPO7	-0.0017494	8485	GTEx	DepMap	Descartes	0.37	3.41
CAT	-0.0023299	9326	GTEx	DepMap	Descartes	0.36	7.31
SNCA	-0.0027419	9807	GTEx	DepMap	Descartes	0.26	4.66
MICAL2	-0.0032983	10310	GTEx	DepMap	Descartes	0.26	2.56
BLVRB	-0.0039914	10825	GTEx	DepMap	Descartes	0.57	20.68
TSPAN5	-0.0040224	10838	GTEx	DepMap	Descartes	0.93	7.36
EPB41	-0.0043592	11047	GTEx	DepMap	Descartes	0.82	4.49
NA	NA	NA	NA	NA	NA	NA	NA

Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.46e-06
Mean rank of genes in gene set: 3750.5
Median rank of genes in gene set: 3322
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CTSD	0.0047632	41	GTEx	DepMap	Descartes	3.07	91.86
HRH1	0.0042434	63	GTEx	DepMap	Descartes	0.28	3.73
ABCA1	0.0041605	65	GTEx	DepMap	Descartes	0.28	1.85
MERTK	0.0022282	268	GTEx	DepMap	Descartes	0.06	1.35
FMN1	0.0019221	361	GTEx	DepMap	Descartes	0.88	4.88
CTSS	0.0018338	389	GTEx	DepMap	Descartes	0.04	1.16
PTPRE	0.0016765	449	GTEx	DepMap	Descartes	0.99	9.34
ITPR2	0.0009178	1054	GTEx	DepMap	Descartes	0.74	3.40
SPP1	0.0008518	1126	GTEx	DepMap	Descartes	0.04	1.14
TGFBI	0.0008168	1162	GTEx	DepMap	Descartes	2.09	26.10
MS4A4A	0.0007910	1194	GTEx	DepMap	Descartes	0.00	0.00
CTSB	0.0007310	1265	GTEx	DepMap	Descartes	2.01	27.33
SLC1A3	0.0003662	2026	GTEx	DepMap	Descartes	0.00	0.00
IFNGR1	0.0002987	2218	GTEx	DepMap	Descartes	0.23	5.18
LGMN	0.0001561	2645	GTEx	DepMap	Descartes	0.34	9.99
SFMBT2	0.0001495	2674	GTEx	DepMap	Descartes	0.11	0.93
MARCH1	0.0000785	2932	GTEx	DepMap	Descartes	0.01	NA
HCK	0.0000593	3005	GTEx	DepMap	Descartes	0.00	0.00
SLCO2B1	0.0000222	3125	GTEx	DepMap	Descartes	0.00	0.00
ADAP2	-0.0000657	3519	GTEx	DepMap	Descartes	0.00	0.00
FGL2	-0.0000712	3542	GTEx	DepMap	Descartes	0.00	0.00
ATP8B4	-0.0001178	3730	GTEx	DepMap	Descartes	0.00	0.00
MSR1	-0.0002036	4107	GTEx	DepMap	Descartes	0.01	0.01
CYBB	-0.0002091	4129	GTEx	DepMap	Descartes	0.00	0.00
CSF1R	-0.0002404	4292	GTEx	DepMap	Descartes	0.01	0.09
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002669	4411	GTEx	DepMap	Descartes	0.00	0.00
SLC9A9	-0.0002916	4534	GTEx	DepMap	Descartes	0.01	0.07
CD163	-0.0003186	4656	GTEx	DepMap	Descartes	0.00	0.00
CPVL	-0.0005374	5474	GTEx	DepMap	Descartes	0.17	5.70

Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.61e-06
Mean rank of genes in gene set: 3828.75
Median rank of genes in gene set: 3752
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
DST	0.0093653	5	GTEx	DepMap	Descartes	8.01	25.60
LAMB1	0.0089770	7	GTEx	DepMap	Descartes	3.00	38.98
SORCS1	0.0042488	62	GTEx	DepMap	Descartes	0.80	5.90
LAMC1	0.0034079	111	GTEx	DepMap	Descartes	1.41	12.67
VCAN	0.0030492	142	GTEx	DepMap	Descartes	2.74	15.75
COL18A1	0.0028870	159	GTEx	DepMap	Descartes	1.27	12.51
PLCE1	0.0027278	179	GTEx	DepMap	Descartes	0.60	3.45
PTN	0.0026492	192	GTEx	DepMap	Descartes	3.25	119.30
HMGA2	0.0014838	553	GTEx	DepMap	Descartes	0.58	7.80
ADAMTS5	0.0006608	1379	GTEx	DepMap	Descartes	0.60	4.45
OLFML2A	0.0006470	1399	GTEx	DepMap	Descartes	0.02	0.26
TRPM3	0.0005639	1553	GTEx	DepMap	Descartes	0.04	0.46
COL5A2	0.0004400	1825	GTEx	DepMap	Descartes	0.18	2.48
XKR4	0.0002721	2300	GTEx	DepMap	Descartes	0.00	0.00
PAG1	0.0001847	2558	GTEx	DepMap	Descartes	0.11	0.60
ERBB3	0.0001356	2733	GTEx	DepMap	Descartes	0.01	0.16
SCN7A	0.0000682	2969	GTEx	DepMap	Descartes	0.03	0.14
EGFLAM	0.0000632	2985	GTEx	DepMap	Descartes	0.01	0.20
KCTD12	0.0000072	3195	GTEx	DepMap	Descartes	0.86	5.96
PLP1	-0.0000151	3317	GTEx	DepMap	Descartes	0.00	0.00
PTPRZ1	-0.0000244	3346	GTEx	DepMap	Descartes	0.00	0.00
FIGN	-0.0000710	3541	GTEx	DepMap	Descartes	0.26	1.70
IL1RAPL2	-0.0001701	3963	GTEx	DepMap	Descartes	0.00	0.00
NRXN3	-0.0001725	3969	GTEx	DepMap	Descartes	0.01	0.03
IL1RAPL1	-0.0002032	4104	GTEx	DepMap	Descartes	0.07	0.90
PPP2R2B	-0.0002215	4199	GTEx	DepMap	Descartes	0.96	5.00
STARD13	-0.0003005	4576	GTEx	DepMap	Descartes	0.09	1.13
COL25A1	-0.0003087	4613	GTEx	DepMap	Descartes	0.01	0.03
LRRTM4	-0.0003151	4645	GTEx	DepMap	Descartes	0.01	0.10
SOX5	-0.0003194	4663	GTEx	DepMap	Descartes	0.05	0.57

Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.93e-02
Mean rank of genes in gene set: 5384.71
Median rank of genes in gene set: 4748
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
LTBP1	0.0055519	24	GTEx	DepMap	Descartes	1.82	20.51
MYLK	0.0013209	660	GTEx	DepMap	Descartes	1.65	9.98
MED12L	0.0007849	1200	GTEx	DepMap	Descartes	0.04	0.25
FLNA	0.0007826	1204	GTEx	DepMap	Descartes	3.66	26.26
SLC2A3	0.0007266	1277	GTEx	DepMap	Descartes	0.06	0.95
ITGB3	0.0005307	1625	GTEx	DepMap	Descartes	0.01	0.25
ARHGAP6	0.0005265	1633	GTEx	DepMap	Descartes	0.15	0.82
THBS1	0.0004430	1818	GTEx	DepMap	Descartes	1.11	10.82
P2RX1	0.0004178	1884	GTEx	DepMap	Descartes	0.00	0.00
MCTP1	0.0002755	2290	GTEx	DepMap	Descartes	0.06	1.32
ITGA2B	0.0002545	2352	GTEx	DepMap	Descartes	0.01	0.09
INPP4B	0.0002459	2373	GTEx	DepMap	Descartes	0.09	0.66
SLC24A3	0.0002279	2433	GTEx	DepMap	Descartes	0.00	0.00
GSN	0.0001221	2786	GTEx	DepMap	Descartes	0.51	4.50
GP1BA	0.0000758	2944	GTEx	DepMap	Descartes	0.00	0.00
STOM	0.0000155	3154	GTEx	DepMap	Descartes	0.29	6.93
TUBB1	0.0000137	3159	GTEx	DepMap	Descartes	0.00	0.00
PLEK	-0.0000313	3376	GTEx	DepMap	Descartes	0.00	0.00
VCL	-0.0000410	3427	GTEx	DepMap	Descartes	1.99	15.34
SPN	-0.0001499	3876	GTEx	DepMap	Descartes	0.00	0.00
MMRN1	-0.0002396	4286	GTEx	DepMap	Descartes	0.00	0.00
PSTPIP2	-0.0003139	4636	GTEx	DepMap	Descartes	0.09	2.15
DOK6	-0.0003383	4748	GTEx	DepMap	Descartes	0.40	1.60
UBASH3B	-0.0003762	4908	GTEx	DepMap	Descartes	0.12	0.94
CD84	-0.0003764	4910	GTEx	DepMap	Descartes	0.00	0.00
MYH9	-0.0004549	5177	GTEx	DepMap	Descartes	2.65	19.31
FLI1	-0.0005056	5367	GTEx	DepMap	Descartes	0.01	0.05
ANGPT1	-0.0005901	5674	GTEx	DepMap	Descartes	0.07	1.25
STON2	-0.0007070	6059	GTEx	DepMap	Descartes	0.03	0.11
RAB27B	-0.0009976	6839	GTEx	DepMap	Descartes	0.18	1.25

Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.74e-01
Mean rank of genes in gene set: 5940.1
Median rank of genes in gene set: 5572
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ANKRD44	0.0019541	346	GTEx	DepMap	Descartes	0.29	1.84
SORL1	0.0011606	796	GTEx	DepMap	Descartes	0.14	0.76
PLEKHA2	0.0010345	929	GTEx	DepMap	Descartes	0.37	4.32
BCL2	0.0009646	1003	GTEx	DepMap	Descartes	0.35	2.20
MCTP2	0.0007639	1219	GTEx	DepMap	Descartes	0.01	0.19
CD44	0.0007634	1221	GTEx	DepMap	Descartes	1.40	16.59
PDE3B	0.0004921	1723	GTEx	DepMap	Descartes	0.20	1.53
ARID5B	0.0003250	2131	GTEx	DepMap	Descartes	1.36	10.07
SCML4	0.0002309	2419	GTEx	DepMap	Descartes	0.00	0.00
RAP1GAP2	0.0002100	2488	GTEx	DepMap	Descartes	0.20	1.69
ABLIM1	0.0001376	2726	GTEx	DepMap	Descartes	0.92	6.54
SAMD3	0.0000020	3222	GTEx	DepMap	Descartes	0.01	0.21
RCSD1	-0.0000830	3586	GTEx	DepMap	Descartes	0.00	0.00
PRKCH	-0.0001477	3870	GTEx	DepMap	Descartes	0.01	0.26
IKZF1	-0.0002069	4119	GTEx	DepMap	Descartes	0.00	0.00
LEF1	-0.0002943	4547	GTEx	DepMap	Descartes	0.05	0.51
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0.00	0.00
SKAP1	-0.0003862	4944	GTEx	DepMap	Descartes	0.00	0.00
BACH2	-0.0004944	5321	GTEx	DepMap	Descartes	0.07	0.30
DOCK10	-0.0005276	5439	GTEx	DepMap	Descartes	0.08	0.57
ARHGAP15	-0.0005529	5540	GTEx	DepMap	Descartes	0.00	0.00
WIPF1	-0.0005708	5604	GTEx	DepMap	Descartes	0.48	4.40
NCALD	-0.0005872	5663	GTEx	DepMap	Descartes	0.18	1.73
FOXP1	-0.0008730	6521	GTEx	DepMap	Descartes	1.23	6.18
MBNL1	-0.0009304	6668	GTEx	DepMap	Descartes	0.77	7.83
TOX	-0.0012608	7523	GTEx	DepMap	Descartes	0.52	5.12
LCP1	-0.0012887	7595	GTEx	DepMap	Descartes	0.00	0.00
ITPKB	-0.0014449	7923	GTEx	DepMap	Descartes	0.04	0.33
PITPNC1	-0.0017835	8537	GTEx	DepMap	Descartes	0.28	1.61
STK39	-0.0021508	9093	GTEx	DepMap	Descartes	0.55	7.42

Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.11e-02
Mean rank of genes in gene set: 1493
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0160377	1	GTEx	DepMap	Descartes	70.27	243.50
SAT1	0.0025288	210	GTEx	DepMap	Descartes	0.91	44.41
TYROBP	-0.0002361	4268	GTEx	DepMap	Descartes	0.00	0.00

T cells: Tem/Effector helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.10e-02
Mean rank of genes in gene set: 2371
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB1	0.0023114	248	GTEx	DepMap	Descartes	10.77	166.62
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
AQP3	-0.0000934	3638	GTEx	DepMap	Descartes	0.03	0.42

T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.02e-02
Mean rank of genes in gene set: 3881.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0081589	9	GTEx	DepMap	Descartes	363.11	3532.25
NUCB2	0.0001014	2843	GTEx	DepMap	Descartes	1.15	21.00
PRKCH	-0.0001477	3870	GTEx	DepMap	Descartes	0.01	0.26
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0.00	0.00
LEF1	-0.0002943	4547	GTEx	DepMap	Descartes	0.05	0.51
CTSW	-0.0004754	5257	GTEx	DepMap	Descartes	0.00	0.00
CD27	-0.0008158	6372	GTEx	DepMap	Descartes	0.00	0.00

Double-positive thymocytes: Double-positive thymocytes (model markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.13e-02
Mean rank of genes in gene set: 3707.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ARPP21	0.0023911	231	GTEx	DepMap	Descartes	0.02	0.32
SH3TC1	0.0013345	649	GTEx	DepMap	Descartes	0.06	1.55
SMPD3	-0.0002511	4343	GTEx	DepMap	Descartes	0.07	0.37
RAG2	-0.0005458	5507	GTEx	DepMap	Descartes	0.01	0.10
CD52	-0.0005582	5562	GTEx	DepMap	Descartes	0.00	0.00
ELOVL4	-0.0006720	5953	GTEx	DepMap	Descartes	0.18	3.43

Double-negative thymocytes: Double-negative thymocytes (curated markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.42e-02
Mean rank of genes in gene set: 1910
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HES1	0.0011113	845	GTEx	DepMap	Descartes	0.42	17.71
FXYD2	0.0000668	2975	GTEx	DepMap	Descartes	0.00	0.00

Monocyte precursor: Monocyte precursor (curated markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.52e-02
Mean rank of genes in gene set: 142
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	0.0030492	142	GTEx	DepMap	Descartes	2.74	15.75

DC precursor: DC precursor (model markers)
dendritic cell precursors that differentiate into dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.56e-02
Mean rank of genes in gene set: 157
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	0.0029082	157	GTEx	DepMap	Descartes	0.61	7.55

T cells: Follicular helper T cells (model markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.67e-02
Mean rank of genes in gene set: 3235.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOCS3	0.0008001	1185	GTEx	DepMap	Descartes	0.23	5.54
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
CH25H	-0.0000836	3590	GTEx	DepMap	Descartes	0.00	0.00
HOXB5	-0.0003856	4941	GTEx	DepMap	Descartes	0.00	0.00

pDC: pDC (model markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.07e-02
Mean rank of genes in gene set: 2079.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	0.0029082	157	GTEx	DepMap	Descartes	0.61	7.55
TRIM71	-0.0001822	4002	GTEx	DepMap	Descartes	0.01	0.01

Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.02e-02
Mean rank of genes in gene set: 3192.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CLDN5	0.0005517	1574	GTEx	DepMap	Descartes	0.01	0.02
SPARCL1	0.0000473	3033	GTEx	DepMap	Descartes	0.01	0.18
PLVAP	-0.0003941	4970	GTEx	DepMap	Descartes	0.00	0.00

B cells: Memory B cells (model markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.63e-02
Mean rank of genes in gene set: 2610.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HES1	0.0011113	845	GTEx	DepMap	Descartes	0.42	17.71
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0.00	0.00

DC: Migratory DCs (curated markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.72e-02
Mean rank of genes in gene set: 2626.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EBI3	0.0020009	326	GTEx	DepMap	Descartes	0.04	2.97
CCR7	-0.0003799	4927	GTEx	DepMap	Descartes	0.00	0.00

B cells: Germinal center B cells (curated markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.86e-02
Mean rank of genes in gene set: 2651
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POU2AF1	4.69e-04	1759	GTEx	DepMap	Descartes	0	0
CD40	-7.14e-05	3543	GTEx	DepMap	Descartes	0	0

B cells: Follicular B cells (curated markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.14e-02
Mean rank of genes in gene set: 2699.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD22	0.0004539	1789	GTEx	DepMap	Descartes	0	0
CXCR5	-0.0000878	3610	GTEx	DepMap	Descartes	0	0

B cells: B cells (model markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.42e-02
Mean rank of genes in gene set: 3393.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0081589	9	GTEx	DepMap	Descartes	363.11	3532.25
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0.00	0.00
CD79A	-0.0006216	5796	GTEx	DepMap	Descartes	0.01	0.04

Macrophages: Kupffer cells (curated markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.46e-02
Mean rank of genes in gene set: 2752.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAM1	0.0002736	2296	GTEx	DepMap	Descartes	0.03	0.48
CD5L	0.0000043	3209	GTEx	DepMap	Descartes	0.00	0.00

Granulocytes: Granulocytes (model markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.46e-02
Mean rank of genes in gene set: 2754
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAK	0.0002851	2263	GTEx	DepMap	Descartes	0	0
SLC10A5	-0.0000017	3245	GTEx	DepMap	Descartes	0	0

Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.07e-01
Mean rank of genes in gene set: 4775.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
F10	0.0051291	36	GTEx	DepMap	Descartes	0.22	9.42
PDGFRA	0.0003557	2047	GTEx	DepMap	Descartes	0.38	3.75
NTRK2	0.0001540	2651	GTEx	DepMap	Descartes	0.05	0.16
ANGPTL1	-0.0000736	3549	GTEx	DepMap	Descartes	0.01	0.19
OLFML1	-0.0004657	5215	GTEx	DepMap	Descartes	0.00	0.00
SMOC2	-0.0006106	5750	GTEx	DepMap	Descartes	0.00	0.00
EBF2	-0.0006390	5850	GTEx	DepMap	Descartes	0.00	0.00
SFRP1	-0.0010644	7013	GTEx	DepMap	Descartes	4.37	39.84
PRRX1	-0.0040654	10867	GTEx	DepMap	Descartes	1.23	15.30

ILC: ILC1 (curated markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.11e-01
Mean rank of genes in gene set: 1848
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF3	0.0004306	1848	GTEx	DepMap	Descartes	0	0

Epithelial cells: Epithelial cells (model markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.13e-01
Mean rank of genes in gene set: 3178.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WFDC2	0.0001867	2549	GTEx	DepMap	Descartes	0.09	4.79
CDH3	-0.0001360	3808	GTEx	DepMap	Descartes	0.00	0.00

ILC: Transitional NK (model markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.14e-01
Mean rank of genes in gene set: 4092.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes
PRDM16	-0.0002096	4131	GTEx	DepMap	Descartes
TYROBP	-0.0002361	4268	GTEx	DepMap	Descartes
AGRP	-0.0003373	4745	GTEx	DepMap	Descartes

Macrophages: Kupffer cells (model markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.19e-01
Mean rank of genes in gene set: 4141.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD5L	0.0000043	3209	GTEx	DepMap	Descartes	0.00	0.00
EGR2	-0.0000232	3341	GTEx	DepMap	Descartes	0.00	0.00
PENK	-0.0003358	4739	GTEx	DepMap	Descartes	0.00	0.00
ARRDC3	-0.0004818	5276	GTEx	DepMap	Descartes	0.32	4.48

T cells: gamma-delta T cells (model markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.20e-01
Mean rank of genes in gene set: 3813
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	0.0002963	2228	GTEx	DepMap	Descartes	0.04	0.05
KLRC2	-0.0002034	4105	GTEx	DepMap	Descartes	0.00	0.00
KCNK10	-0.0004334	5106	GTEx	DepMap	Descartes	0.06	0.05

ILC: CD16- NK cells (curated markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.30e-01
Mean rank of genes in gene set: 2191
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD160	0.0003092	2191	GTEx	DepMap	Descartes	0.01	0.11

B-cell lineage: Small pre-B cells (model markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.31e-01
Mean rank of genes in gene set: 4246
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLDC2	0.0001200	2793	GTEx	DepMap	Descartes	0.00	NA
AICDA	-0.0001338	3802	GTEx	DepMap	Descartes	0.00	0.00
CD79B	-0.0003313	4722	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.33e-01
Mean rank of genes in gene set: 3426
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	0.0002963	2228	GTEx	DepMap	Descartes	0.04	0.05
KL	-0.0003103	4624	GTEx	DepMap	Descartes	0.00	0.00

T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.36e-01
Mean rank of genes in gene set: 3464
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
INPP5J	0.0004065	1914	GTEx	DepMap	Descartes	0.06	1.54
PANX2	-0.0004079	5014	GTEx	DepMap	Descartes	0.12	1.88

T cells: NKT cells (model markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.37e-01
Mean rank of genes in gene set: 3983.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITM2C	0.0002860	2258	GTEx	DepMap	Descartes	2.24	43.39
PRDM16	-0.0002096	4131	GTEx	DepMap	Descartes	0.00	0.00
CD52	-0.0005582	5562	GTEx	DepMap	Descartes	0.00	0.00

HSC/MPP: HSC/MPP (model markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.40e-01
Mean rank of genes in gene set: 3508.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	0.0002963	2228	GTEx	DepMap	Descartes	0.04	0.05
SPINK2	-0.0003447	4789	GTEx	DepMap	Descartes	0.00	0.00

pDC: pDC (curated markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.42e-01
Mean rank of genes in gene set: 2395
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLD4	0.0002375	2395	GTEx	DepMap	Descartes	0.01	0.16

Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.51e-01
Mean rank of genes in gene set: 4408.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMRN2	0.0002868	2256	GTEx	DepMap	Descartes	0.01	0.17
VWF	0.0001003	2848	GTEx	DepMap	Descartes	0.01	0.12
RAMP3	-0.0004395	5124	GTEx	DepMap	Descartes	0.00	0.00
JAM2	-0.0012153	7406	GTEx	DepMap	Descartes	0.12	0.62

ILC: CD16+ NK cells (model markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.54e-01
Mean rank of genes in gene set: 4626.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADAMTS1	0.0009240	1048	GTEx	DepMap	Descartes	0.51	4.44
FCER1G	-0.0000682	3529	GTEx	DepMap	Descartes	0.01	0.38
TYROBP	-0.0002361	4268	GTEx	DepMap	Descartes	0.00	0.00
PRSS57	-0.0003338	4730	GTEx	DepMap	Descartes	0.00	0.00
IGFBP7	-0.0025130	9556	GTEx	DepMap	Descartes	0.09	4.09

T cells: MAIT cells (curated markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.59e-01
Mean rank of genes in gene set: 3714.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0	0
SLC4A10	-0.0002219	4202	GTEx	DepMap	Descartes	0	0

Megakaryocytes/platelets: Megakaryocytes/platelets (curated markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.61e-01
Mean rank of genes in gene set: 3740
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	0.0002545	2352	GTEx	DepMap	Descartes	0.01	0.09
CMTM5	-0.0004403	5128	GTEx	DepMap	Descartes	0.00	0.00

Mast cells: Mast cells (model markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.64e-01
Mean rank of genes in gene set: 2738
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	0.0001347	2738	GTEx	DepMap	Descartes	0	0

Macrophages: Macrophages (curated markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.66e-01
Mean rank of genes in gene set: 2764
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD68	0.000128	2764	GTEx	DepMap	Descartes	0.25	8.1

T cells: Memory CD4+ cytotoxic T cells (curated markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.81e-01
Mean rank of genes in gene set: 3940.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD4	-0.0001246	3756	GTEx	DepMap	Descartes	0	0
IL10	-0.0002084	4125	GTEx	DepMap	Descartes	0	0

DC: DC3 (model markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.82e-01
Mean rank of genes in gene set: 3948.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	0.0029082	157	GTEx	DepMap	Descartes	0.61	7.55
BMP3	-0.0013596	7740	GTEx	DepMap	Descartes	0.01	0.08

T cells: Type 1 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.90e-01
Mean rank of genes in gene set: 4029
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TBX21	-0.0000353	3403	GTEx	DepMap	Descartes	0	0
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0	0

T cells: Regulatory T cells (curated markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.04e-01
Mean rank of genes in gene set: 3277
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-7.4e-06	3277	GTEx	DepMap	Descartes	0.01	0.11

ILC: ILC (model markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.04e-01
Mean rank of genes in gene set: 4777.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	0.0002963	2228	GTEx	DepMap	Descartes	0.04	0.05
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
AREG	-0.0008299	6414	GTEx	DepMap	Descartes	0.00	0.00
IL7R	-0.0011441	7241	GTEx	DepMap	Descartes	0.02	0.22

HSC/MPP: CMP (model markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.09e-01
Mean rank of genes in gene set: 4202.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	0.0001347	2738	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.16e-01
Mean rank of genes in gene set: 5002
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0081589	9	GTEx	DepMap	Descartes	363.11	3532.25
ITM2A	0.0015594	515	GTEx	DepMap	Descartes	0.10	3.35
CD44	0.0007634	1221	GTEx	DepMap	Descartes	1.40	16.59
SATB1	-0.0039022	10772	GTEx	DepMap	Descartes	0.73	3.97
TMSB10	-0.0139576	12493	GTEx	DepMap	Descartes	41.81	3593.20

Mast cells: Mast cells (curated markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.17e-01
Mean rank of genes in gene set: 4268
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	0.0001347	2738	GTEx	DepMap	Descartes	0.00	0.00
TPSB2	-0.0006219	5798	GTEx	DepMap	Descartes	0.08	2.57

Double-negative thymocytes: Double-negative thymocytes (model markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.17e-01
Mean rank of genes in gene set: 5119.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MFAP4	0.0004093	1907	GTEx	DepMap	Descartes	1.49	41.52
MZB1	0.0000686	2966	GTEx	DepMap	Descartes	0.00	NA
FXYD2	0.0000668	2975	GTEx	DepMap	Descartes	0.00	0.00
CD7	-0.0005450	5504	GTEx	DepMap	Descartes	0.01	0.13
SELL	-0.0008085	6352	GTEx	DepMap	Descartes	0.00	0.00
PDLIM1	-0.0042992	11014	GTEx	DepMap	Descartes	0.57	21.90

ILC: ILC2 (model markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.18e-01
Mean rank of genes in gene set: 3452
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL17RB	-4.82e-05	3452	GTEx	DepMap	Descartes	0	0

Double-positive thymocytes: Double-positive thymocytes (curated markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.21e-01
Mean rank of genes in gene set: 4308
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0.00	0.00
SMPD3	-0.0002511	4343	GTEx	DepMap	Descartes	0.07	0.37

HSC/MPP: HSC/MPP (curated markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.22e-01
Mean rank of genes in gene set: 4675
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	-0.0002879	4520	GTEx	DepMap	Descartes	0.01	0.03
CRHBP	-0.0003304	4716	GTEx	DepMap	Descartes	0.00	0.00
SPINK2	-0.0003447	4789	GTEx	DepMap	Descartes	0.00	0.00

MNP: MNP (curated markers)
mononuclear phagocytes including dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.25e-01
Mean rank of genes in gene set: 3542
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FGL2	-7.12e-05	3542	GTEx	DepMap	Descartes	0	0

ETP: ETP (model markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.37e-01
Mean rank of genes in gene set: 4442.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-0.0002122	4146	GTEx	DepMap	Descartes	0	0
PENK	-0.0003358	4739	GTEx	DepMap	Descartes	0	0

T cells: Tem/Trm cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.40e-01
Mean rank of genes in gene set: 4464
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0	0
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0	0

B cells: Follicular B cells (model markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.44e-01
Mean rank of genes in gene set: 4498
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VPREB3	0.0000365	3062	GTEx	DepMap	Descartes	0.01	0.94
CD83	-0.0006681	5934	GTEx	DepMap	Descartes	0.02	0.40

T cells: Tem/Trm cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.46e-01
Mean rank of genes in gene set: 4838.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes
CST7	-0.0005670	5588	GTEx	DepMap	Descartes

ETP: ETP (curated markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.64e-01
Mean rank of genes in gene set: 4654.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	-0.0002879	4520	GTEx	DepMap	Descartes	0.01	0.03
SPINK2	-0.0003447	4789	GTEx	DepMap	Descartes	0.00	0.00

Early MK: Early MK (model markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.66e-01
Mean rank of genes in gene set: 4671.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCDC175	-0.0001013	3676	GTEx	DepMap	Descartes	0.00	NA
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

T cells: Follicular helper T cells (curated markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.68e-01
Mean rank of genes in gene set: 4689
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-8.78e-05	3610	GTEx	DepMap	Descartes	0	0
PDCD1	-6.15e-04	5768	GTEx	DepMap	Descartes	0	0

T cells: Tcm/Naive helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.73e-01
Mean rank of genes in gene set: 5011.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes
CD4	-0.0001246	3756	GTEx	DepMap	Descartes
CCR7	-0.0003799	4927	GTEx	DepMap	Descartes
SELL	-0.0008085	6352	GTEx	DepMap	Descartes

B-cell lineage: Large pre-B cells (model markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.75e-01
Mean rank of genes in gene set: 4104
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0002032	4104	GTEx	DepMap	Descartes	0.07	0.9

DC: DC1 (model markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.75e-01
Mean rank of genes in gene set: 4104
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0002032	4104	GTEx	DepMap	Descartes	0.07	0.9

Erythrocytes: Erythrocytes (model markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.75e-01
Mean rank of genes in gene set: 4104
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0002032	4104	GTEx	DepMap	Descartes	0.07	0.9

T cells: Tem/Effector helper T cells PD1+ (curated markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.77e-01
Mean rank of genes in gene set: 4762
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD4	-0.0001246	3756	GTEx	DepMap	Descartes	0	0
PDCD1	-0.0006150	5768	GTEx	DepMap	Descartes	0	0

DC: Migratory DCs (model markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.78e-01
Mean rank of genes in gene set: 4146
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-0.0002122	4146	GTEx	DepMap	Descartes	0	0

Granulocytes: Granulocytes (curated markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.80e-01
Mean rank of genes in gene set: 5053
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	0.0001347	2738	GTEx	DepMap	Descartes	0.00	0.00
SLC45A3	-0.0005145	5392	GTEx	DepMap	Descartes	0.05	0.69
KIT	-0.0010700	7029	GTEx	DepMap	Descartes	0.01	0.07

T cells: NKT cells (curated markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.90e-01
Mean rank of genes in gene set: 4273
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0	0

Macrophages: Kidney-resident macrophages (curated markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.00e-01
Mean rank of genes in gene set: 4376
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0	0

ILC precursor: ILC precursor (model markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.00e-01
Mean rank of genes in gene set: 5180.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPN	-0.0003003	4573	GTEx	DepMap	Descartes	0.0	0.00
PDZK1	-0.0005318	5456	GTEx	DepMap	Descartes	0.0	0.00
HUNK	-0.0005466	5512	GTEx	DepMap	Descartes	0.2	1.02

Erythroid: Early erythroid (model markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.01e-01
Mean rank of genes in gene set: 5329
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FAM178B	0.0000113	3168	GTEx	DepMap	Descartes	0.00	0.00
PRSS57	-0.0003338	4730	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15
APOC1	-0.0013652	7751	GTEx	DepMap	Descartes	0.14	15.47

T cells: Tcm/Naive cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.01e-01
Mean rank of genes in gene set: 5184
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes
CCR7	-0.0003799	4927	GTEx	DepMap	Descartes
SELL	-0.0008085	6352	GTEx	DepMap	Descartes

B cells: B cells (curated markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.02e-01
Mean rank of genes in gene set: 4949.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0002028	4103	GTEx	DepMap	Descartes	0.00	0.00
CD79A	-0.0006216	5796	GTEx	DepMap	Descartes	0.01	0.04

Monocytes: Classical monocytes (curated markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.03e-01
Mean rank of genes in gene set: 4411
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD14	-0.0002669	4411	GTEx	DepMap	Descartes	0	0

Erythroid: Late erythroid (model markers)
late erythroid cells following early and middle erythroid cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.09e-01
Mean rank of genes in gene set: 4994
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC12A3	-0.0002451	4321	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.13e-01
Mean rank of genes in gene set: 5256.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LST1	0.0000616	2993	GTEx	DepMap	Descartes	0.00	0.00
HPN	-0.0003003	4573	GTEx	DepMap	Descartes	0.00	0.00
SCN1B	-0.0016116	8204	GTEx	DepMap	Descartes	0.06	0.49

Megakaryocyte precursor: Megakaryocyte precursor (model markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.20e-01
Mean rank of genes in gene set: 5077.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC10A5	-0.0000017	3245	GTEx	DepMap	Descartes	0	0
ADRA2A	-0.0010250	6910	GTEx	DepMap	Descartes	0	0

Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.25e-01
Mean rank of genes in gene set: 5325.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0011707	788	GTEx	DepMap	Descartes	0.44	6.61
DCN	-0.0008165	6373	GTEx	DepMap	Descartes	0.12	1.45
COL1A1	-0.0019570	8815	GTEx	DepMap	Descartes	4.36	51.78

ILC: Transitional NK (curated markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.27e-01
Mean rank of genes in gene set: 4655
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0	0

T cells: gamma-delta T cells (curated markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.27e-01
Mean rank of genes in gene set: 4655
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0	0

DC: DC1 (curated markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.34e-01
Mean rank of genes in gene set: 5179
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CADM1	0.0003747	2001	GTEx	DepMap	Descartes	1.06	6.11
BATF3	-0.0016793	8357	GTEx	DepMap	Descartes	0.01	0.31

T cells: Memory CD4+ cytotoxic T cells (model markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.36e-01
Mean rank of genes in gene set: 4739
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	-0.0003358	4739	GTEx	DepMap	Descartes	0	0

T cells: Trm cytotoxic T cells (model markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.36e-01
Mean rank of genes in gene set: 5389.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0.00	0.00
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0.00	0.00
IL7R	-0.0011441	7241	GTEx	DepMap	Descartes	0.02	0.22

pDC precursor: pDC precursor (model markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.36e-01
Mean rank of genes in gene set: 4745
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	-0.0003373	4745	GTEx	DepMap	Descartes	0	0

DC: DC (model markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.60e-01
Mean rank of genes in gene set: 4977
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0003956	4977	GTEx	DepMap	Descartes	0	0

Macrophages: Hofbauer cells (model markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.64e-01
Mean rank of genes in gene set: 5014
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PANX2	-0.0004079	5014	GTEx	DepMap	Descartes	0.12	1.88

Early MK: Early MK (curated markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.76e-01
Mean rank of genes in gene set: 5128
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	-0.0004403	5128	GTEx	DepMap	Descartes	0	0

Cycling cells: Cycling B cells (model markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.78e-01
Mean rank of genes in gene set: 5622.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	0.0002963	2228	GTEx	DepMap	Descartes	0.04	0.05
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15
RGS13	-0.0020572	8973	GTEx	DepMap	Descartes	0.00	0.00

Epithelial cells: Epithelial cells (curated markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.84e-01
Mean rank of genes in gene set: 5206
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT17	-0.0004623	5206	GTEx	DepMap	Descartes	0	0

Plasma cells: Plasma cells (curated markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.90e-01
Mean rank of genes in gene set: 5558.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MZB1	0.0000686	2966	GTEx	DepMap	Descartes	0.00	NA
XBP1	-0.0015808	8151	GTEx	DepMap	Descartes	1.04	22.23

T cells: MAIT cells (model markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.92e-01
Mean rank of genes in gene set: 5779.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
KLRG1	-0.0003762	4909	GTEx	DepMap	Descartes	0.10	3.51
IL7R	-0.0011441	7241	GTEx	DepMap	Descartes	0.02	0.22
BMP3	-0.0013596	7740	GTEx	DepMap	Descartes	0.01	0.08

ILC: ILC3 (curated markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.06e-01
Mean rank of genes in gene set: 5779.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RORC	-0.0002419	4308	GTEx	DepMap	Descartes	0.00	0.00
IL4I1	-0.0006862	6001	GTEx	DepMap	Descartes	0.01	0.02
KIT	-0.0010700	7029	GTEx	DepMap	Descartes	0.01	0.07

HSC/MPP: ELP (curated markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.08e-01
Mean rank of genes in gene set: 5681.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LTB	-0.0002653	4399	GTEx	DepMap	Descartes	0.00	0.00
RUNX2	-0.0010468	6964	GTEx	DepMap	Descartes	0.11	1.64

Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.11e-01
Mean rank of genes in gene set: 5866
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
APOE	0.0050132	37	GTEx	DepMap	Descartes	4.08	209.02
CD5L	0.0000043	3209	GTEx	DepMap	Descartes	0.00	0.00
APOC1	-0.0013652	7751	GTEx	DepMap	Descartes	0.14	15.47
FTH1	-0.0130109	12467	GTEx	DepMap	Descartes	40.32	1318.83

DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.12e-01
Mean rank of genes in gene set: 5809.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP9	-0.0000933	3637	GTEx	DepMap	Descartes	0.00	0.00
AGRP	-0.0003373	4745	GTEx	DepMap	Descartes	0.00	0.00
CST3	-0.0021133	9046	GTEx	DepMap	Descartes	5.32	87.33

Granulocytes: Neutrophils (curated markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.20e-01
Mean rank of genes in gene set: 5547
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCN2	-0.0005534	5547	GTEx	DepMap	Descartes	0	0

B cells: Germinal center B cells (model markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.22e-01
Mean rank of genes in gene set: 5771
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AICDA	-0.0001338	3802	GTEx	DepMap	Descartes	0.00	0.00
BMP3	-0.0013596	7740	GTEx	DepMap	Descartes	0.01	0.08

T cells: Treg(diff) (curated markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-01
Mean rank of genes in gene set: 5923.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCR7	-0.0003799	4927	GTEx	DepMap	Descartes	0.00	0.00
CD27	-0.0008158	6372	GTEx	DepMap	Descartes	0.00	0.00
IKZF4	-0.0008551	6471	GTEx	DepMap	Descartes	0.21	1.27

Cycling cells: Cycling T cells (model markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-01
Mean rank of genes in gene set: 5667
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

ILC: ILC3 (model markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-01
Mean rank of genes in gene set: 5667
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

Promyelocytes: Promyelocytes (model markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.33e-01
Mean rank of genes in gene set: 5667
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15

Mono-mac: Mono-mac (curated markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.57e-01
Mean rank of genes in gene set: 5995.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TYROBP	-0.0002361	4268	GTEx	DepMap	Descartes	0.00	0.0
HMOX1	-0.0013521	7723	GTEx	DepMap	Descartes	0.07	4.4

Plasma cells: Plasma cells (model markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.63e-01
Mean rank of genes in gene set: 6104.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MZB1	0.0000686	2966	GTEx	DepMap	Descartes	0.00	NA
ST18	-0.0008897	6562	GTEx	DepMap	Descartes	0.00	0.00
TGFBR3L	-0.0009535	6739	GTEx	DepMap	Descartes	0.13	NA
XBP1	-0.0015808	8151	GTEx	DepMap	Descartes	1.04	22.23

ILC: CD16- NK cells (model markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.65e-01
Mean rank of genes in gene set: 6154.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
FCER1G	-0.0000682	3529	GTEx	DepMap	Descartes	0.01	0.38
TYROBP	-0.0002361	4268	GTEx	DepMap	Descartes	0.00	0.00
CXCL3	-0.0002537	4354	GTEx	DepMap	Descartes	0.00	0.00
LDB2	-0.0012857	7586	GTEx	DepMap	Descartes	0.04	1.31
CLIC3	-0.0013108	7634	GTEx	DepMap	Descartes	0.03	1.61
GSTP1	-0.0134663	12484	GTEx	DepMap	Descartes	11.39	249.39

T cells: Trm cytotoxic T cells (curated markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.68e-01
Mean rank of genes in gene set: 6072
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA1	0.0026730	186	GTEx	DepMap	Descartes	1.02	5.59
ITGAE	-0.0071684	11958	GTEx	DepMap	Descartes	0.76	6.61

Macrophages: Hofbauer cells (curated markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.81e-01
Mean rank of genes in gene set: 6101
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCIN	-0.0007222	6101	GTEx	DepMap	Descartes	0.01	0.1

T cells: Type 17 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.94e-01
Mean rank of genes in gene set: 6236.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZBTB16	-0.0004695	5232	GTEx	DepMap	Descartes	0.00	0.00
IL7R	-0.0011441	7241	GTEx	DepMap	Descartes	0.02	0.22

T cells: Tcm/Naive helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.99e-01
Mean rank of genes in gene set: 6271.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FCGRT	0.0026700	187	GTEx	DepMap	Descartes	1.54	33.58
LTB	-0.0002653	4399	GTEx	DepMap	Descartes	0.00	0.00
CTSL	-0.0014917	8007	GTEx	DepMap	Descartes	0.78	NA
TMSB10	-0.0139576	12493	GTEx	DepMap	Descartes	41.81	3593.20

HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.06e-01
Mean rank of genes in gene set: 6315.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	0.0002545	2352	GTEx	DepMap	Descartes	0.01	0.09
GATA2	-0.0032622	10279	GTEx	DepMap	Descartes	2.46	23.01

B cells: Memory B cells (curated markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.11e-01
Mean rank of genes in gene set: 6372
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD27	-0.0008158	6372	GTEx	DepMap	Descartes	0	0

B-cell lineage: Small pre-B cells (curated markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.15e-01
Mean rank of genes in gene set: 6409
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0008277	6409	GTEx	DepMap	Descartes	2.31	28.86

B-cell lineage: Pro-B cells (curated markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.15e-01
Mean rank of genes in gene set: 6409
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0008277	6409	GTEx	DepMap	Descartes	2.31	28.86

HSC/MPP: Early lymphoid/T lymphoid (model markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.32e-01
Mean rank of genes in gene set: 6562
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.0008897	6562	GTEx	DepMap	Descartes	0	0

Mono-mac: Mono-mac (model markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.53e-01
Mean rank of genes in gene set: 6514.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SAT1	0.0025288	210	GTEx	DepMap	Descartes	0.91	44.41
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
S100A2	-0.0031051	10155	GTEx	DepMap	Descartes	0.23	11.89
FTH1	-0.0130109	12467	GTEx	DepMap	Descartes	40.32	1318.83

B cells: Transitional B cells (curated markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.70e-01
Mean rank of genes in gene set: 6916
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYO1C	-0.0010273	6916	GTEx	DepMap	Descartes	1.13	11.55

T cells: Regulatory T cells (model markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.80e-01
Mean rank of genes in gene set: 6639.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TIGIT	-0.0000144	3313	GTEx	DepMap	Descartes	0.00	0.00
RGS1	-0.0003956	4977	GTEx	DepMap	Descartes	0.00	0.00
SRGN	-0.0018406	8625	GTEx	DepMap	Descartes	0.09	5.86
RTKN2	-0.0025904	9644	GTEx	DepMap	Descartes	0.31	3.03

Monocyte precursor: Monocyte precursor (model markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.97e-01
Mean rank of genes in gene set: 6902.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.0008897	6562	GTEx	DepMap	Descartes	0.00	0.00
CUX2	-0.0011452	7243	GTEx	DepMap	Descartes	0.08	0.11

T cells: Tem/Temra cytotoxic T cells (model markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.05e-01
Mean rank of genes in gene set: 7241
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0011441	7241	GTEx	DepMap	Descartes	0.02	0.22

HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.05e-01
Mean rank of genes in gene set: 7243
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0011452	7243	GTEx	DepMap	Descartes	0.08	0.11

ILC: ILC2 (curated markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.18e-01
Mean rank of genes in gene set: 6901.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPGDS	-0.0003136	4635	GTEx	DepMap	Descartes	0.00	0.00
KLRG1	-0.0003762	4909	GTEx	DepMap	Descartes	0.10	3.51
GATA3	-0.0045885	11160	GTEx	DepMap	Descartes	3.52	37.60

Cycling cells: Cycling DCs (model markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.36e-01
Mean rank of genes in gene set: 7532
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP12	-0.001266	7532	GTEx	DepMap	Descartes	0.01	0.15

T cells: Type 1 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.46e-01
Mean rank of genes in gene set: 6881
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
PRDM16	-0.0002096	4131	GTEx	DepMap	Descartes	0.00	0.00
CCL5	-0.0003184	4655	GTEx	DepMap	Descartes	0.00	0.00
CEBPB	-0.0033444	10346	GTEx	DepMap	Descartes	0.58	16.28
ANXA1	-0.0075910	12046	GTEx	DepMap	Descartes	0.96	23.93

B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.49e-01
Mean rank of genes in gene set: 7256
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0.0	0
YBX3	-0.0030793	10136	GTEx	DepMap	Descartes	0.1	NA

pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.62e-01
Mean rank of genes in gene set: 7342.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IRF7	-0.0000974	3656	GTEx	DepMap	Descartes	0.09	1.60
CCDC50	-0.0043172	11029	GTEx	DepMap	Descartes	0.97	4.86

T cells: T(agonist) (curated markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.81e-01
Mean rank of genes in gene set: 7261.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MIR155HG	-0.0001848	4018	GTEx	DepMap	Descartes	0.00	0.00
BIRC3	-0.0005373	5473	GTEx	DepMap	Descartes	0.01	0.08
SMS	-0.0099355	12294	GTEx	DepMap	Descartes	2.39	50.97

Megakaryocyte precursor: Megakaryocyte precursor (curated markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.84e-01
Mean rank of genes in gene set: 7504.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRSS57	-0.0003338	4730	GTEx	DepMap	Descartes	0.00	0.00
GATA2	-0.0032622	10279	GTEx	DepMap	Descartes	2.46	23.01

T cells: Tcm/Naive cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.95e-01
Mean rank of genes in gene set: 7578.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002369	4273	GTEx	DepMap	Descartes	0.00	0.00
B2M	-0.0040878	10884	GTEx	DepMap	Descartes	9.39	221.96

B-cell lineage: Large pre-B cells (curated markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.96e-01
Mean rank of genes in gene set: 7586.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0008277	6409	GTEx	DepMap	Descartes	2.31	28.86
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73

Erythroid: Early erythroid (curated markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.22e-01
Mean rank of genes in gene set: 7506.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TESPA1	-0.0002823	4490	GTEx	DepMap	Descartes	0.00	NA
APOC1	-0.0013652	7751	GTEx	DepMap	Descartes	0.14	15.47
GATA2	-0.0032622	10279	GTEx	DepMap	Descartes	2.46	23.01

B-cell lineage: Pre-pro-B cells (curated markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.34e-01
Mean rank of genes in gene set: 7875.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0011441	7241	GTEx	DepMap	Descartes	0.02	0.22
ZCCHC7	-0.0017652	8510	GTEx	DepMap	Descartes	0.63	9.24

T cells: Tem/Effector helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.67e-01
Mean rank of genes in gene set: 7352.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
AQP3	-0.0000934	3638	GTEx	DepMap	Descartes	0.03	0.42
LTB	-0.0002653	4399	GTEx	DepMap	Descartes	0.00	0.00
DONSON	-0.0022464	9208	GTEx	DepMap	Descartes	0.16	2.43
S100A4	-0.0056694	11596	GTEx	DepMap	Descartes	0.48	31.59
ANXA1	-0.0075910	12046	GTEx	DepMap	Descartes	0.96	23.93

Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.80e-01
Mean rank of genes in gene set: 8251
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KCNH2	-0.0001856	4023	GTEx	DepMap	Descartes	1.08	10.03
PRDX2	-0.0133857	12479	GTEx	DepMap	Descartes	8.57	161.35

Monocytes: Classical monocytes (model markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.86e-01
Mean rank of genes in gene set: 7931
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CST7	-0.0005670	5588	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0005885	5667	GTEx	DepMap	Descartes	0.01	0.15
EEF1A1	-0.0179702	12538	GTEx	DepMap	Descartes	92.48	690.97

Cycling cells: Cycling B cells (curated markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.11e-01
Mean rank of genes in gene set: 8115
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0002028	4103	GTEx	DepMap	Descartes	0.00	0.00
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16

DC: Transitional DC (curated markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.22e-01
Mean rank of genes in gene set: 8639
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AXL	-0.0016976	8391	GTEx	DepMap	Descartes	0.5	6.81
KLF4	-0.0020078	8887	GTEx	DepMap	Descartes	0.0	0.00

T cells: CD8a/a (curated markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.40e-01
Mean rank of genes in gene set: 8824.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0006150	5768	GTEx	DepMap	Descartes	0.00	0
GNG4	-0.0067779	11881	GTEx	DepMap	Descartes	1.82	7

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (curated markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.66e-01
Mean rank of genes in gene set: 10279
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GATA2	-0.0032622	10279	GTEx	DepMap	Descartes	2.46	23.01

ILC: ILC (curated markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.88e-01
Mean rank of genes in gene set: 8816.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AREG	-0.0008299	6414	GTEx	DepMap	Descartes	0.00	0.00
TLE1	-0.0021258	9063	GTEx	DepMap	Descartes	0.55	5.17
S100A13	-0.0042247	10973	GTEx	DepMap	Descartes	0.48	8.97

T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.88e-01
Mean rank of genes in gene set: 7942.86
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITM2A	0.0015594	515	GTEx	DepMap	Descartes	0.10	3.35
CD74	-0.0002604	4376	GTEx	DepMap	Descartes	0.00	0.00
BIRC3	-0.0005373	5473	GTEx	DepMap	Descartes	0.01	0.08
PTPRC	-0.0030938	10150	GTEx	DepMap	Descartes	0.00	0.00
B2M	-0.0040878	10884	GTEx	DepMap	Descartes	9.39	221.96
COTL1	-0.0069059	11908	GTEx	DepMap	Descartes	0.77	8.14
SMS	-0.0099355	12294	GTEx	DepMap	Descartes	2.39	50.97

T cells: CD8a/b(entry) (curated markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.93e-01
Mean rank of genes in gene set: 10772
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SATB1	-0.0039022	10772	GTEx	DepMap	Descartes	0.73	3.97

B cells: Transitional B cells (model markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.94e-01
Mean rank of genes in gene set: 10791
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GNG3	-0.003931	10791	GTEx	DepMap	Descartes	0.17	1.81

T cells: Type 17 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.00e-01
Mean rank of genes in gene set: 8956.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	0.0000012	3227	GTEx	DepMap	Descartes	0.00	0.00
S100A4	-0.0056694	11596	GTEx	DepMap	Descartes	0.48	31.59
ANXA1	-0.0075910	12046	GTEx	DepMap	Descartes	0.96	23.93

T cells: Treg(diff) (model markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.05e-01
Mean rank of genes in gene set: 8648.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0003956	4977	GTEx	DepMap	Descartes	0.00	0.00
TSC22D3	-0.0014190	7870	GTEx	DepMap	Descartes	0.21	3.95
PTPRC	-0.0030938	10150	GTEx	DepMap	Descartes	0.00	0.00
S100A4	-0.0056694	11596	GTEx	DepMap	Descartes	0.48	31.59

ILC: NK cells (model markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.10e-01
Mean rank of genes in gene set: 8107.14
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0081589	9	GTEx	DepMap	Descartes	363.11	3532.25
SPINK2	-0.0003447	4789	GTEx	DepMap	Descartes	0.00	0.00
HMOX1	-0.0013521	7723	GTEx	DepMap	Descartes	0.07	4.40
CST3	-0.0021133	9046	GTEx	DepMap	Descartes	5.32	87.33
IGFBP4	-0.0044466	11092	GTEx	DepMap	Descartes	1.05	25.32
KLHL23	-0.0056906	11603	GTEx	DepMap	Descartes	1.15	7.22
STMN1	-0.0136868	12488	GTEx	DepMap	Descartes	9.96	94.98

Monocytes: Non-classical monocytes (model markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.32e-01
Mean rank of genes in gene set: 8977
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0011452	7243	GTEx	DepMap	Descartes	0.08	0.11
BAG3	-0.0014172	7865	GTEx	DepMap	Descartes	0.18	4.45
ABI3	-0.0023290	9323	GTEx	DepMap	Descartes	0.00	0.00
RHOC	-0.0053033	11477	GTEx	DepMap	Descartes	2.09	44.19

Cycling cells: Cycling DCs (curated markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10121
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16

Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10121
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16

Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10121
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16

Cycling cells: Cycling NK cells (curated markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10121
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16

Cycling cells: Cycling T cells (curated markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 10121
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0019265	8764	GTEx	DepMap	Descartes	2.35	8.73
TOP2A	-0.0053048	11478	GTEx	DepMap	Descartes	2.07	19.16

HSC/MPP: Early lymphoid/T lymphoid (curated markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.43e-01
Mean rank of genes in gene set: 10326.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ETS1	-0.0024708	9493	GTEx	DepMap	Descartes	0.42	2.24
GATA3	-0.0045885	11160	GTEx	DepMap	Descartes	3.52	37.60

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.47e-01
Mean rank of genes in gene set: 12131
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CKB	-0.008166	12131	GTEx	DepMap	Descartes	5.31	112.1

Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 10011.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TYROBP	-0.0002361	4268	GTEx	DepMap	Descartes	0.00	0.00
SRGN	-0.0018406	8625	GTEx	DepMap	Descartes	0.09	5.86
S100A6	-0.0085525	12167	GTEx	DepMap	Descartes	14.57	1175.95
FTH1	-0.0130109	12467	GTEx	DepMap	Descartes	40.32	1318.83
ACTB	-0.0169224	12529	GTEx	DepMap	Descartes	28.73	553.80

B cells: Naive B cells (curated markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
DC: DC (curated markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
DC: DC2 (curated markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
DC: DC3 (curated markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
DC precursor: DC precursor (curated markers)
dendritic cell precursors that differentiate into dendritic cells:
Erythrocytes: Erythrocytes (curated markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Erythroid: Late erythroid (curated markers)
late erythroid cells following early and middle erythroid cells:
HSC/MPP: CMP (curated markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
HSC/MPP: GMP (curated markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: Neutrophil-myeloid progenitor (curated markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
ILC: CD16+ NK cells (curated markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
ILC: NK cells (curated markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Monocytes: Non-classical monocytes (curated markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Monocytes: Monocytes (curated markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Myelocytes: Myelocytes (curated markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Promyelocytes: Promyelocytes (curated markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
T cells: Tem/Temra cytotoxic T cells (curated markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
B-cell lineage: Pre-pro-B cells (model markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
B-cell lineage: Pro-B cells (model markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Cycling cells: Cycling gamma-delta T cells (model markers)
proliferating gamma-delta (γδ) T lymphocytes:
Cycling cells: Cycling monocytes (model markers)
proliferating monocytes:
DC: Transitional DC (model markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Erythroid: Mid erythroid (model markers)
middle erythroid cells in fetal liver:
Granulocytes: Neutrophils (model markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
HSC/MPP: ELP (model markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
HSC/MPP: GMP (model markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: MEMP (model markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
ILC: ILC1 (model markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Macrophages: Kidney-resident macrophages (model markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Megakaryocytes/platelets: Megakaryocytes/platelets (model markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
MNP: MNP (model markers)
mononuclear phagocytes including dendritic cells: