Program: 2. Myelocyte: Unknown.

Program: 2. Myelocyte: Unknown.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program. Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret. The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program (currently only calculated for the cells in the first 50/50 split of the data). Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 SLC11A1 0.0200982 solute carrier family 11 member 1 GTEx DepMap Descartes 2.76 407.71
2 AQP9 0.0193902 aquaporin 9 GTEx DepMap Descartes 3.35 788.25
3 CD300E 0.0187931 CD300e molecule GTEx DepMap Descartes 0.96 258.89
4 SERPINB2 0.0138911 serpin family B member 2 GTEx DepMap Descartes 8.64 2896.69
5 ST6GALNAC2 0.0131868 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 GTEx DepMap Descartes 0.01 3.31
6 CFP 0.0116960 complement factor properdin GTEx DepMap Descartes 0.99 159.36
7 PLAUR 0.0116333 plasminogen activator, urokinase receptor GTEx DepMap Descartes 7.53 3739.64
8 CSF3R 0.0115859 colony stimulating factor 3 receptor GTEx DepMap Descartes 1.15 150.94
9 EREG 0.0114510 epiregulin GTEx DepMap Descartes 8.01 1114.77
10 CTSS 0.0109714 cathepsin S GTEx DepMap Descartes 6.07 692.01
11 FCER1G 0.0103716 Fc epsilon receptor Ig GTEx DepMap Descartes 4.71 4320.78
12 S100A4 0.0101944 S100 calcium binding protein A4 GTEx DepMap Descartes 4.08 3729.02
13 ATP2B1 0.0101817 ATPase plasma membrane Ca2+ transporting 1 GTEx DepMap Descartes 4.99 447.68
14 NLRP3 0.0100157 NLR family pyrin domain containing 3 GTEx DepMap Descartes 0.78 130.85
15 PPIF 0.0098646 peptidylprolyl isomerase F GTEx DepMap Descartes 2.36 883.69
16 BASP1 0.0097931 brain abundant membrane attached signal protein 1 GTEx DepMap Descartes 6.84 2381.65
17 ANPEP 0.0095402 alanyl aminopeptidase, membrane GTEx DepMap Descartes 1.05 263.10
18 HCK 0.0094421 HCK proto-oncogene, Src family tyrosine kinase GTEx DepMap Descartes 2.47 552.37
19 TLR2 0.0091526 toll like receptor 2 GTEx DepMap Descartes 2.01 272.94
20 CXCL3 0.0090652 C-X-C motif chemokine ligand 3 GTEx DepMap Descartes 17.44 8742.05
21 TYROBP 0.0088685 transmembrane immune signaling adaptor TYROBP GTEx DepMap Descartes 7.01 5803.14
22 IRAK3 0.0088383 interleukin 1 receptor associated kinase 3 GTEx DepMap Descartes 1.27 81.90
23 SLC25A37 0.0087952 solute carrier family 25 member 37 GTEx DepMap Descartes 2.12 303.21
24 SLC2A6 0.0086248 solute carrier family 2 member 6 GTEx DepMap Descartes 2.26 305.02
25 IL1RN 0.0085384 interleukin 1 receptor antagonist GTEx DepMap Descartes 7.64 2323.40
26 NCF2 0.0084170 neutrophil cytosolic factor 2 GTEx DepMap Descartes 0.93 127.88
27 GK 0.0083988 glycerol kinase GTEx DepMap Descartes 0.95 163.70
28 DMXL2 0.0082240 Dmx like 2 GTEx DepMap Descartes 1.91 85.09
29 SOD2 0.0079524 superoxide dismutase 2 GTEx DepMap Descartes 24.05 961.94
30 FTH1 0.0079082 ferritin heavy chain 1 GTEx DepMap Descartes 46.99 19482.72
31 MXD1 0.0077842 MAX dimerization protein 1 GTEx DepMap Descartes 1.12 183.49
32 ITGAX 0.0075098 integrin subunit alpha X GTEx DepMap Descartes 3.16 410.81
33 ACTB 0.0074942 actin beta GTEx DepMap Descartes 22.72 5151.21
34 G0S2 0.0074178 G0/G1 switch 2 GTEx DepMap Descartes 5.99 3515.19
35 IL1B 0.0073501 interleukin 1 beta GTEx DepMap Descartes 38.88 12906.83
36 PTGS2 0.0073325 prostaglandin-endoperoxide synthase 2 GTEx DepMap Descartes 6.11 859.47
37 AIF1 0.0073236 allograft inflammatory factor 1 GTEx DepMap Descartes 1.96 629.72
38 CYBB 0.0073112 cytochrome b-245 beta chain GTEx DepMap Descartes 1.82 229.94
39 SLC43A2 0.0071872 solute carrier family 43 member 2 GTEx DepMap Descartes 1.12 123.47
40 TNFRSF1B 0.0071784 TNF receptor superfamily member 1B GTEx DepMap Descartes 5.71 863.39
41 FFAR2 0.0071539 free fatty acid receptor 2 GTEx DepMap Descartes 0.57 179.51
42 TIMP1 0.0071152 TIMP metallopeptidase inhibitor 1 GTEx DepMap Descartes 20.96 12739.31
43 CYBA 0.0071152 cytochrome b-245 alpha chain GTEx DepMap Descartes 2.42 897.49
44 KYNU 0.0071144 kynureninase GTEx DepMap Descartes 2.49 87.60
45 ZEB2 0.0071143 zinc finger E-box binding homeobox 2 GTEx DepMap Descartes 4.56 307.10
46 NAMPT 0.0069511 nicotinamide phosphoribosyltransferase GTEx DepMap Descartes 4.63 550.54
47 DOK3 0.0068993 docking protein 3 GTEx DepMap Descartes 0.65 208.59
48 SPI1 0.0068917 Spi-1 proto-oncogene GTEx DepMap Descartes 1.51 525.59
49 WARS 0.0068523 NA GTEx DepMap Descartes 2.61 NA
50 ACSL1 0.0068456 acyl-CoA synthetase long chain family member 1 GTEx DepMap Descartes 2.39 292.32


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UMAP plots showing activity of gene expression program identified in community:2. Myelocyte: Unknown

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 2. Myelocyte: Unknown:
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_DENDRITIC_CELLS 6.65e-41 148.02 78.60 1.49e-38 4.46e-38
26SLC11A1, CFP, PLAUR, CSF3R, EREG, CTSS, FCER1G, S100A4, NLRP3, TYROBP, NCF2, SOD2, FTH1, MXD1, ACTB, G0S2, IL1B, PTGS2, AIF1, CYBB, TNFRSF1B, TIMP1, CYBA, ZEB2, NAMPT, SPI1
 117
TRAVAGLINI_LUNG_OLR1_CLASSICAL_MONOCYTE_CELL 7.03e-52 165.57 65.64 4.72e-49 4.72e-49
45SLC11A1, AQP9, CD300E, CFP, PLAUR, CSF3R, EREG, CTSS, FCER1G, ATP2B1, NLRP3, PPIF, BASP1, ANPEP, HCK, TLR2, CXCL3, TYROBP, IRAK3, SLC25A37, SLC2A6, IL1RN, NCF2, GK, DMXL2, SOD2, FTH1, MXD1, ITGAX, ACTB, G0S2, IL1B, PTGS2, AIF1, CYBB, SLC43A2, TNFRSF1B, FFAR2, TIMP1, KYNU, ZEB2, NAMPT, DOK3, SPI1, ACSL1
 726
AIZARANI_LIVER_C23_KUPFFER_CELLS_3 6.37e-43 107.25 57.54 2.14e-40 4.27e-40
31SLC11A1, CD300E, CFP, PLAUR, CSF3R, EREG, CTSS, FCER1G, S100A4, ATP2B1, BASP1, HCK, TLR2, TYROBP, IRAK3, SLC25A37, NCF2, GK, SOD2, FTH1, ITGAX, ACTB, IL1B, PTGS2, AIF1, CYBB, SLC43A2, TNFRSF1B, ZEB2, NAMPT, DOK3
 221
AIZARANI_LIVER_C25_KUPFFER_CELLS_4 3.21e-32 76.78 41.16 4.30e-30 2.15e-29
24SLC11A1, PLAUR, EREG, CTSS, FCER1G, ATP2B1, NLRP3, BASP1, HCK, TLR2, CXCL3, TYROBP, IRAK3, IL1RN, NCF2, FTH1, ITGAX, ACTB, IL1B, AIF1, CYBB, TNFRSF1B, ZEB2, NAMPT
 174
AIZARANI_LIVER_C31_KUPFFER_CELLS_5 1.41e-24 68.82 35.18 1.35e-22 9.44e-22
18SLC11A1, CD300E, PLAUR, CTSS, FCER1G, ATP2B1, TYROBP, IRAK3, SLC25A37, IL1RN, ITGAX, IL1B, AIF1, CYBB, SLC43A2, TNFRSF1B, ZEB2, NAMPT
 120
AIZARANI_LIVER_C18_NK_NKT_CELLS_5 1.08e-22 61.82 31.27 7.46e-21 7.26e-20
17SLC11A1, PLAUR, CTSS, FCER1G, ATP2B1, HCK, TLR2, TYROBP, IRAK3, NCF2, FTH1, ITGAX, IL1B, AIF1, CYBB, TNFRSF1B, ZEB2
 121
TRAVAGLINI_LUNG_EREG_DENDRITIC_CELL 8.08e-35 48.81 26.03 1.35e-32 5.42e-32
34SLC11A1, CD300E, PLAUR, EREG, FCER1G, NLRP3, PPIF, BASP1, ANPEP, HCK, TLR2, CXCL3, TYROBP, IRAK3, SLC25A37, IL1RN, NCF2, GK, SOD2, FTH1, MXD1, ITGAX, ACTB, G0S2, IL1B, AIF1, CYBB, SLC43A2, TIMP1, KYNU, ZEB2, NAMPT, SPI1, ACSL1
 579
DESCARTES_FETAL_STOMACH_MYELOID_CELLS 5.49e-15 54.12 23.93 1.84e-13 3.68e-12
11PLAUR, CSF3R, FCER1G, HCK, TYROBP, NCF2, ITGAX, IL1B, CYBB, TNFRSF1B, SPI1
 76
TRAVAGLINI_LUNG_NONCLASSICAL_MONOCYTE_CELL 2.63e-21 43.37 22.42 1.36e-19 1.76e-18
18SLC11A1, CD300E, CFP, CTSS, FCER1G, HCK, TYROBP, IRAK3, NCF2, DMXL2, FTH1, ITGAX, CYBB, TNFRSF1B, TIMP1, KYNU, ZEB2, SPI1
 180
TRAVAGLINI_LUNG_MACROPHAGE_CELL 4.78e-22 42.08 22.02 2.67e-20 3.21e-19
19SLC11A1, AQP9, PLAUR, CTSS, FCER1G, ANPEP, HCK, CXCL3, TYROBP, IL1RN, NCF2, GK, SOD2, FTH1, IL1B, CYBB, SLC43A2, KYNU, ACSL1
 201
GAO_LARGE_INTESTINE_24W_C11_PANETH_LIKE_CELL 1.29e-25 38.31 20.81 1.44e-23 8.67e-23
24CD300E, CFP, PLAUR, CSF3R, FCER1G, NLRP3, PPIF, HCK, TLR2, CXCL3, TYROBP, SLC25A37, IL1RN, NCF2, SOD2, ITGAX, IL1B, PTGS2, AIF1, CYBB, TNFRSF1B, KYNU, NAMPT, SPI1
 325
TRAVAGLINI_LUNG_CLASSICAL_MONOCYTE_CELL 1.11e-22 36.35 19.42 7.46e-21 7.46e-20
21SLC11A1, CD300E, CFP, CSF3R, CTSS, FCER1G, S100A4, NLRP3, HCK, TLR2, TYROBP, IRAK3, NCF2, DMXL2, CYBB, TNFRSF1B, KYNU, ZEB2, DOK3, SPI1, ACSL1
 270
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 5.26e-21 36.65 19.23 2.52e-19 3.53e-18
19SLC11A1, CFP, CTSS, FCER1G, BASP1, HCK, TLR2, TYROBP, IRAK3, FTH1, ITGAX, ACTB, IL1B, AIF1, CYBB, TNFRSF1B, CYBA, ZEB2, SPI1
 228
BUSSLINGER_ESOPHAGEAL_DENDRITIC_CELLS 2.09e-18 32.67 16.77 8.75e-17 1.40e-15
17CFP, PLAUR, CTSS, S100A4, ATP2B1, BASP1, HCK, TYROBP, FTH1, ITGAX, ACTB, IL1B, PTGS2, AIF1, CYBB, TIMP1, SPI1
 214
TRAVAGLINI_LUNG_NEUTROPHIL_CELL 7.77e-23 30.85 16.73 6.52e-21 5.21e-20
23SLC11A1, AQP9, PLAUR, CSF3R, CTSS, BASP1, ANPEP, TLR2, TYROBP, IRAK3, SLC25A37, NCF2, SOD2, FTH1, MXD1, ITGAX, G0S2, PTGS2, FFAR2, NAMPT, DOK3, SPI1, ACSL1
 368
CUI_DEVELOPING_HEART_C8_MACROPHAGE 1.77e-19 29.91 15.75 7.94e-18 1.19e-16
19PLAUR, CSF3R, CTSS, FCER1G, S100A4, NLRP3, BASP1, HCK, TLR2, TYROBP, NCF2, SOD2, ITGAX, AIF1, CYBB, TNFRSF1B, CYBA, NAMPT, SPI1
 275
HAY_BONE_MARROW_NEUTROPHIL 2.41e-22 27.17 14.80 1.47e-20 1.62e-19
24SLC11A1, AQP9, SERPINB2, CFP, PLAUR, CSF3R, EREG, S100A4, BASP1, ANPEP, TLR2, TYROBP, IRAK3, IL1RN, NCF2, DMXL2, MXD1, ACTB, PTGS2, CYBB, CYBA, KYNU, DOK3, ACSL1
 449
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 7.03e-16 28.93 14.43 2.48e-14 4.72e-13
15PLAUR, CTSS, FCER1G, NLRP3, BASP1, HCK, TLR2, TYROBP, NCF2, FTH1, ITGAX, IL1B, AIF1, CYBB, TNFRSF1B
 200
DESCARTES_FETAL_INTESTINE_MYELOID_CELLS 1.67e-16 27.88 14.14 6.24e-15 1.12e-13
16CD300E, CFP, CSF3R, CTSS, FCER1G, NLRP3, HCK, TYROBP, NCF2, ITGAX, IL1B, AIF1, CYBB, KYNU, NAMPT, SPI1
 227
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MACROPHAGES 8.68e-10 32.57 12.75 2.01e-08 5.82e-07
8PLAUR, CTSS, FCER1G, TYROBP, IL1B, AIF1, CYBA, SPI1
 81

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_INFLAMMATORY_RESPONSE 1.98e-14 26.13 12.79 9.89e-13 9.89e-13
14AQP9, PLAUR, CSF3R, EREG, ATP2B1, NLRP3, TLR2, MXD1, IL1B, CYBB, TNFRSF1B, FFAR2, TIMP1, NAMPT
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 5.03e-13 23.47 11.26 1.26e-11 2.51e-11
13SERPINB2, PLAUR, ATP2B1, TLR2, CXCL3, SLC2A6, SOD2, MXD1, G0S2, IL1B, PTGS2, KYNU, NAMPT
 200
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.29e-05 16.92 5.11 2.29e-04 1.14e-03
5CSF3R, TLR2, CXCL3, IL1B, TNFRSF1B
 87
HALLMARK_ALLOGRAFT_REJECTION 9.73e-07 12.40 4.96 1.22e-05 4.87e-05
8CFP, EREG, CTSS, NLRP3, TLR2, IL1B, TIMP1, SPI1
 200
HALLMARK_KRAS_SIGNALING_UP 9.73e-07 12.40 4.96 1.22e-05 4.87e-05
8PLAUR, EREG, CTSS, FCER1G, G0S2, IL1B, PTGS2, TNFRSF1B
 200
HALLMARK_COMPLEMENT 1.24e-04 8.78 3.02 1.03e-03 6.18e-03
6SERPINB2, PLAUR, CTSS, FCER1G, TIMP1, KYNU
 200
HALLMARK_APOPTOSIS 3.63e-03 6.92 1.79 2.59e-02 1.82e-01
4EREG, SOD2, IL1B, TIMP1
 161
HALLMARK_ANGIOGENESIS 8.94e-03 15.30 1.73 4.97e-02 4.47e-01
2S100A4, TIMP1
 36
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 7.71e-03 5.55 1.44 4.82e-02 3.85e-01
4PLAUR, BASP1, ANPEP, TIMP1
 200
HALLMARK_INTERFERON_GAMMA_RESPONSE 4.35e-02 4.05 0.80 2.18e-01 1.00e+00
3SOD2, PTGS2, NAMPT
 200
HALLMARK_PEROXISOME 6.35e-02 5.11 0.59 2.89e-01 1.00e+00
2SOD2, ACSL1
 104
HALLMARK_BILE_ACID_METABOLISM 7.22e-02 4.73 0.55 3.01e-01 1.00e+00
2AQP9, ACSL1
 112
HALLMARK_COAGULATION 1.03e-01 3.83 0.45 3.95e-01 1.00e+00
2SERPINB2, TIMP1
 138
HALLMARK_FATTY_ACID_METABOLISM 1.28e-01 3.34 0.39 4.02e-01 1.00e+00
2G0S2, ACSL1
 158
HALLMARK_UV_RESPONSE_UP 1.28e-01 3.34 0.39 4.02e-01 1.00e+00
2PPIF, SOD2
 158
HALLMARK_IL2_STAT5_SIGNALING 1.83e-01 2.64 0.31 4.02e-01 1.00e+00
2MXD1, TNFRSF1B
 199
HALLMARK_HYPOXIA 1.85e-01 2.63 0.31 4.02e-01 1.00e+00
2PLAUR, S100A4
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 4.02e-01 1.00e+00
2ST6GALNAC2, PPIF
 200
HALLMARK_MTORC1_SIGNALING 1.85e-01 2.63 0.31 4.02e-01 1.00e+00
2CFP, NAMPT
 200
HALLMARK_XENOBIOTIC_METABOLISM 1.85e-01 2.63 0.31 4.02e-01 1.00e+00
2AQP9, KYNU
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_LEISHMANIA_INFECTION 9.11e-06 20.72 6.22 1.69e-03 1.69e-03
5TLR2, NCF2, IL1B, PTGS2, CYBA
 72
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.11e-03 9.70 2.49 1.03e-01 2.07e-01
4NCF2, ACTB, CYBB, CYBA
 116
KEGG_HEMATOPOIETIC_CELL_LINEAGE 4.89e-03 9.50 1.85 3.03e-01 9.10e-01
3CSF3R, ANPEP, IL1B
 87
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 1.96e-02 4.16 1.08 8.10e-01 1.00e+00
4CSF3R, CXCL3, IL1B, TNFRSF1B
 265
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 2.50e-02 8.68 1.00 8.10e-01 1.00e+00
2NLRP3, IL1B
 62
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 2.89e-02 8.01 0.92 8.10e-01 1.00e+00
2TNFRSF1B, ACSL1
 67
KEGG_PPAR_SIGNALING_PATHWAY 3.05e-02 7.77 0.90 8.10e-01 1.00e+00
2GK, ACSL1
 69
KEGG_PEROXISOME 3.81e-02 6.85 0.79 8.86e-01 1.00e+00
2SOD2, ACSL1
 78
KEGG_APOPTOSIS 4.64e-02 6.13 0.71 9.59e-01 1.00e+00
2IRAK3, IL1B
 87
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 6.14e-02 5.21 0.60 1.00e+00 1.00e+00
2TLR2, IL1B
 102
KEGG_LYSOSOME 8.24e-02 4.38 0.51 1.00e+00 1.00e+00
2SLC11A1, CTSS
 121
KEGG_PATHWAYS_IN_CANCER 1.32e-01 2.48 0.49 1.00e+00 1.00e+00
3CSF3R, PTGS2, SPI1
 325
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.01e-01 3.86 0.45 1.00e+00 1.00e+00
2FCER1G, TYROBP
 137
KEGG_RENIN_ANGIOTENSIN_SYSTEM 6.56e-02 15.93 0.37 1.00e+00 1.00e+00
1ANPEP
 17
KEGG_CHEMOKINE_SIGNALING_PATHWAY 1.70e-01 2.79 0.33 1.00e+00 1.00e+00
2HCK, CXCL3
 189
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 2.03e-01 2.47 0.29 1.00e+00 1.00e+00
2ITGAX, ACTB
 213
KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM 9.13e-02 11.08 0.26 1.00e+00 1.00e+00
1NAMPT
 24
KEGG_ASTHMA 1.13e-01 8.79 0.21 1.00e+00 1.00e+00
1FCER1G
 30
KEGG_PRION_DISEASES 1.30e-01 7.50 0.18 1.00e+00 1.00e+00
1IL1B
 35
KEGG_TRYPTOPHAN_METABOLISM 1.47e-01 6.54 0.16 1.00e+00 1.00e+00
1KYNU
 40

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2q22 2.97e-02 7.89 0.91 1.00e+00 1.00e+00
2KYNU, ZEB2
 68
chrXp21 4.17e-02 6.51 0.75 1.00e+00 1.00e+00
2GK, CYBB
 82
chr2q14 1.23e-01 3.43 0.40 1.00e+00 1.00e+00
2IL1RN, IL1B
 154
chr15q21 1.40e-01 3.16 0.37 1.00e+00 1.00e+00
2AQP9, DMXL2
 167
chr17q25 3.22e-01 1.77 0.21 1.00e+00 1.00e+00
2CD300E, ST6GALNAC2
 297
chrXp11 6.55e-01 1.42 0.17 1.00e+00 1.00e+00
2CFP, TIMP1
 370
chr1q21 6.64e-01 1.34 0.16 1.00e+00 1.00e+00
2CTSS, S100A4
 392
chr19q13 7.98e-01 0.69 0.14 1.00e+00 1.00e+00
3PLAUR, TYROBP, FFAR2
 1165
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1PTGS2
 71
chr12q14 3.41e-01 2.45 0.06 1.00e+00 1.00e+00
1IRAK3
 105
chr4q35 3.41e-01 2.45 0.06 1.00e+00 1.00e+00
1ACSL1
 105
chr7p22 3.82e-01 2.13 0.05 1.00e+00 1.00e+00
1ACTB
 121
chr2q35 3.94e-01 2.04 0.05 1.00e+00 1.00e+00
1SLC11A1
 126
chr12q21 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1ATP2B1
 128
chr8p21 3.99e-01 2.01 0.05 1.00e+00 1.00e+00
1SLC25A37
 128
chr16q24 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1CYBA
 130
chr2p13 4.20e-01 1.88 0.05 1.00e+00 1.00e+00
1MXD1
 137
chr11p11 4.38e-01 1.77 0.04 1.00e+00 1.00e+00
1SPI1
 145
chr6q25 4.57e-01 1.67 0.04 1.00e+00 1.00e+00
1SOD2
 154
chr4q31 4.64e-01 1.64 0.04 1.00e+00 1.00e+00
1TLR2
 157

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
RYTTCCTG_ETS2_B 1.32e-04 4.00 1.94 1.50e-01 1.50e-01
13CSF3R, CTSS, FCER1G, PPIF, TYROBP, IL1RN, NCF2, GK, FTH1, ACTB, TIMP1, ZEB2, SPI1
 1112
ICSBP_Q6 2.97e-03 5.60 1.72 1.00e+00 1.00e+00
5EREG, CTSS, AIF1, KYNU, ZEB2
 253
IRF1_Q6 3.50e-03 5.38 1.65 1.00e+00 1.00e+00
5CTSS, ATP2B1, TYROBP, KYNU, ZEB2
 263
CEBPB_02 3.67e-03 5.32 1.64 1.00e+00 1.00e+00
5AQP9, FCER1G, NLRP3, G0S2, ZEB2
 266
TTANTCA_UNKNOWN 8.28e-03 2.87 1.22 1.00e+00 1.00e+00
9AQP9, SERPINB2, EREG, FCER1G, NLRP3, SOD2, PTGS2, TIMP1, ZEB2
 967
IRF_Q6 1.50e-02 4.53 1.17 1.00e+00 1.00e+00
4EREG, CYBB, KYNU, ZEB2
 244
CEBPDELTA_Q6 1.56e-02 4.47 1.16 1.00e+00 1.00e+00
4IL1RN, G0S2, ZEB2, DOK3
 247
ISRE_01 1.69e-02 4.37 1.13 1.00e+00 1.00e+00
4EREG, AIF1, KYNU, ZEB2
 253
HNF1_Q6 1.75e-02 4.31 1.12 1.00e+00 1.00e+00
4AQP9, ANPEP, CXCL3, ZEB2
 256
STAT6_02 1.84e-02 4.25 1.10 1.00e+00 1.00e+00
4CSF3R, ZEB2, DOK3, SPI1
 260
PEA3_Q6 1.91e-02 4.20 1.09 1.00e+00 1.00e+00
4CTSS, NLRP3, NCF2, SPI1
 263
RACCACAR_AML_Q6 2.03e-02 4.12 1.07 1.00e+00 1.00e+00
4CFP, FCER1G, SLC43A2, ZEB2
 268
ETS2_B 2.36e-02 3.92 1.02 1.00e+00 1.00e+00
4TYROBP, SLC43A2, ZEB2, SPI1
 281
MAPK3_TARGET_GENES 2.73e-02 8.26 0.95 1.00e+00 1.00e+00
2SOD2, ACTB
 65
ZNF768_TARGET_GENES 5.47e-02 2.05 0.88 1.00e+00 1.00e+00
9ST6GALNAC2, CSF3R, CTSS, S100A4, TYROBP, NCF2, FTH1, ITGAX, TIMP1
 1346
ZNF589_TARGET_GENES 4.39e-02 2.50 0.87 1.00e+00 1.00e+00
6ANPEP, SOD2, MXD1, ACTB, ZEB2, SPI1
 688
EGFR_TARGET_GENES 3.14e-02 36.29 0.79 1.00e+00 1.00e+00
1ACTB
 8
TGGAAA_NFAT_Q4_01 2.07e-01 1.63 0.72 1.00e+00 1.00e+00
10FCER1G, ATP2B1, SLC25A37, IL1RN, FTH1, SLC43A2, TNFRSF1B, FFAR2, KYNU, ZEB2
 1934
PAX3_B 5.02e-02 5.85 0.68 1.00e+00 1.00e+00
2GK, ZEB2
 91
ADNP_TARGET_GENES 5.32e-02 5.66 0.66 1.00e+00 1.00e+00
2CSF3R, CTSS
 94

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_SMOOTH_MUSCLE_ADAPTATION 1.54e-04 172.68 14.09 2.25e-02 1.00e+00
2IL1B, CYBA
 5
GOBP_RESPIRATORY_BURST 2.77e-07 44.73 12.98 1.48e-04 2.07e-03
5SLC11A1, HCK, NCF2, CYBB, CYBA
 36
GOBP_CELLULAR_RESPONSE_TO_ETHANOL 3.20e-05 61.17 10.83 6.30e-03 2.40e-01
3SOD2, CYBB, SPI1
 16
GOBP_POSITIVE_REGULATION_OF_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS 3.22e-04 103.49 9.64 4.01e-02 1.00e+00
2IL1B, PTGS2
 7
GOBP_POSITIVE_REGULATION_OF_FEVER_GENERATION 3.22e-04 103.49 9.64 4.01e-02 1.00e+00
2IL1B, PTGS2
 7
GOBP_SUPEROXIDE_ANION_GENERATION 1.05e-05 34.98 8.63 2.47e-03 7.89e-02
4TYROBP, NCF2, CYBB, CYBA
 35
GOBP_FIBROBLAST_GROWTH_FACTOR_PRODUCTION 5.49e-04 74.10 7.33 5.64e-02 1.00e+00
2PTGS2, AIF1
 9
GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS 5.49e-04 74.10 7.33 5.64e-02 1.00e+00
2IL1B, PTGS2
 9
GOBP_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS 9.91e-05 39.79 7.33 1.58e-02 7.41e-01
3IL1B, TNFRSF1B, TIMP1
 23
GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION 1.04e-06 21.30 7.21 4.33e-04 7.79e-03
6EREG, TLR2, TYROBP, IL1B, AIF1, CYBA
 86
GOBP_CELL_REDOX_HOMEOSTASIS 2.42e-05 27.83 6.94 5.03e-03 1.81e-01
4SLC11A1, NCF2, CYBB, CYBA
 43
GOBP_REGULATION_OF_PHAGOCYTOSIS 1.76e-06 19.35 6.57 5.97e-04 1.31e-02
6SLC11A1, FCER1G, HCK, TLR2, IL1B, CYBA
 94
GOBP_FEVER_GENERATION 6.85e-04 64.86 6.55 6.19e-02 1.00e+00
2IL1B, PTGS2
 10
GOBP_POSITIVE_REGULATION_OF_HEAT_GENERATION 6.85e-04 64.86 6.55 6.19e-02 1.00e+00
2IL1B, PTGS2
 10
GOBP_SUPEROXIDE_METABOLIC_PROCESS 7.93e-06 21.34 6.41 2.05e-03 5.93e-02
5TYROBP, NCF2, SOD2, CYBB, CYBA
 70
GOBP_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE 1.62e-04 33.18 6.19 2.28e-02 1.00e+00
3IL1B, PTGS2, FFAR2
 27
GOBP_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE 3.76e-05 24.69 6.19 7.21e-03 2.81e-01
4NLRP3, IL1B, PTGS2, FFAR2
 48
GOBP_NAD_BIOSYNTHETIC_PROCESS 2.01e-04 30.63 5.74 2.78e-02 1.00e+00
3PTGS2, KYNU, NAMPT
 29
GOBP_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS 6.44e-05 21.29 5.37 1.12e-02 4.82e-01
4SOD2, IL1B, PTGS2, CYBA
 55
GOBP_REGULATION_OF_HEAT_GENERATION 1.18e-03 47.19 4.96 9.53e-02 1.00e+00
2IL1B, PTGS2
 13

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE29618_MONOCYTE_VS_PDC_UP 8.78e-24 46.53 24.55 2.37e-20 4.28e-20
20CFP, CTSS, S100A4, NLRP3, PPIF, HCK, TLR2, TYROBP, IRAK3, IL1RN, NCF2, SOD2, ITGAX, G0S2, AIF1, TNFRSF1B, TIMP1, NAMPT, SPI1, ACSL1
 199
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 9.71e-24 46.27 24.41 2.37e-20 4.73e-20
20SLC11A1, CFP, PLAUR, CSF3R, FCER1G, NLRP3, BASP1, ANPEP, HCK, TLR2, TYROBP, SLC2A6, IL1RN, NCF2, DMXL2, ITGAX, AIF1, CYBB, KYNU, ACSL1
 200
GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_DN 6.65e-19 35.18 18.04 8.10e-16 3.24e-15
17SLC11A1, CFP, PLAUR, CSF3R, FCER1G, S100A4, NLRP3, ANPEP, TLR2, TYROBP, IL1RN, NCF2, DMXL2, ACTB, AIF1, TNFRSF1B, TIMP1
 200
GSE29618_MONOCYTE_VS_MDC_UP 6.65e-19 35.18 18.04 8.10e-16 3.24e-15
17SLC11A1, CSF3R, CTSS, FCER1G, S100A4, NLRP3, TYROBP, IRAK3, NCF2, DMXL2, SOD2, G0S2, AIF1, CYBB, TNFRSF1B, NAMPT, ACSL1
 200
GSE34156_NOD2_LIGAND_VS_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_DN 1.78e-17 32.48 16.43 1.74e-14 8.69e-14
16ANPEP, HCK, TLR2, CXCL3, TYROBP, SLC25A37, NCF2, GK, DMXL2, ACTB, CYBB, SLC43A2, TIMP1, KYNU, DOK3, ACSL1
 197
GSE6269_FLU_VS_STAPH_AUREUS_INF_PBMC_DN 1.63e-15 31.76 15.50 7.94e-13 7.94e-12
14SLC11A1, PLAUR, CSF3R, PPIF, ANPEP, TLR2, IL1RN, GK, SOD2, FTH1, MXD1, TIMP1, SPI1, ACSL1
 167
GSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_UP 5.62e-16 29.42 14.66 3.81e-13 2.74e-12
15SLC11A1, ANPEP, HCK, TLR2, CXCL3, TYROBP, SLC25A37, NCF2, GK, DMXL2, ACTB, CYBB, TIMP1, KYNU, DOK3
 197
GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_1H_UP 5.62e-16 29.42 14.66 3.81e-13 2.74e-12
15PLAUR, PPIF, HCK, TLR2, CXCL3, SLC2A6, SOD2, MXD1, G0S2, IL1B, PTGS2, TNFRSF1B, FFAR2, NAMPT, ACSL1
 197
GSE29618_PDC_VS_MDC_DN 7.03e-16 28.93 14.43 3.81e-13 3.43e-12
15CFP, S100A4, ATP2B1, PPIF, BASP1, HCK, IRAK3, IL1RN, NCF2, ITGAX, PTGS2, AIF1, TIMP1, NAMPT, SPI1
 200
GSE29618_PDC_VS_MDC_DAY7_FLU_VACCINE_DN 7.03e-16 28.93 14.43 3.81e-13 3.43e-12
15CFP, S100A4, ATP2B1, NLRP3, PPIF, BASP1, HCK, TLR2, IRAK3, IL1RN, NCF2, ITGAX, IL1B, AIF1, TIMP1
 200
GSE25123_CTRL_VS_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_UP 1.61e-14 26.55 13.00 6.42e-12 7.83e-11
14AQP9, CFP, PLAUR, EREG, NLRP3, PPIF, CXCL3, SLC25A37, IL1RN, GK, MXD1, ITGAX, IL1B, NAMPT
 197
GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_DN 1.98e-14 26.13 12.79 6.42e-12 9.64e-11
14AQP9, CFP, CSF3R, FCER1G, HCK, TYROBP, NCF2, SOD2, PTGS2, AIF1, TNFRSF1B, FFAR2, NAMPT, ACSL1
 200
GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN 1.98e-14 26.13 12.79 6.42e-12 9.64e-11
14SLC11A1, CFP, CSF3R, CTSS, FCER1G, HCK, TLR2, TYROBP, IRAK3, NCF2, DMXL2, CYBB, TNFRSF1B, ACSL1
 200
GSE29618_MONOCYTE_VS_PDC_DAY7_FLU_VACCINE_UP 1.98e-14 26.13 12.79 6.42e-12 9.64e-11
14CSF3R, CTSS, NLRP3, HCK, TLR2, IL1RN, NCF2, SOD2, G0S2, AIF1, TNFRSF1B, TIMP1, NAMPT, ACSL1
 200
GSE36888_UNTREATED_VS_IL2_TREATED_TCELL_17H_DN 1.98e-14 26.13 12.79 6.42e-12 9.64e-11
14PLAUR, FCER1G, HCK, TLR2, CXCL3, SLC25A37, GK, SOD2, FTH1, G0S2, PTGS2, KYNU, NAMPT, ACSL1
 200
GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_UP 1.51e-13 25.98 12.44 4.61e-11 7.38e-10
13CSF3R, BASP1, CXCL3, IRAK3, SLC25A37, IL1RN, DMXL2, SOD2, FTH1, MXD1, IL1B, PTGS2, TNFRSF1B
 182
GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_3H_UP 4.72e-13 23.60 11.32 1.35e-10 2.30e-09
13AQP9, PLAUR, EREG, CXCL3, IRAK3, SLC2A6, SOD2, G0S2, IL1B, PTGS2, TNFRSF1B, NAMPT, ACSL1
 199
GSE29618_MONOCYTE_VS_MDC_DAY7_FLU_VACCINE_UP 5.03e-13 23.47 11.26 1.36e-10 2.45e-09
13SLC11A1, CSF3R, CTSS, IRAK3, NCF2, DMXL2, SOD2, G0S2, AIF1, CYBB, TNFRSF1B, NAMPT, ACSL1
 200
GSE25123_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_DAY10_DN 8.57e-12 21.58 10.09 2.14e-09 4.17e-08
12EREG, FCER1G, PPIF, TLR2, CXCL3, SLC25A37, IL1RN, NCF2, IL1B, PTGS2, AIF1, TIMP1
 195
GSE9988_LOW_LPS_VS_VEHICLE_TREATED_MONOCYTE_UP 9.09e-12 21.44 10.03 2.14e-09 4.43e-08
12AQP9, PLAUR, EREG, ATP2B1, NLRP3, CXCL3, GK, SOD2, G0S2, IL1B, PTGS2, ACSL1
 196

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
NLRP3 14 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the signaling cascade
HCK 18 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits TP73-mediated transcription activation (PMID: 17535448)
TLR2 19 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Upstream of NFKB and not involved in DNA-binding
IRAK3 22 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MXD1 31 Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).
IL1B 35 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZEB2 45 Yes Inferred motif Monomer or homomultimer In vivo/Misc source None None
SPI1 48 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MAFB 66 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence
PLEK 67 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs
HAVCR2 70 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RXRA 87 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZBTB43 97 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NLRP12 102 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ITGB2 109 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MTF1 134 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ENO1 140 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Enolase - DNA binding not shown to be direct
PRDM8 147 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None
JARID2 148 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Only ARID3 and ARID5 family members have sequence specificity (PMID: 15640446).
NOD2 150 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
TM116-H4 Monocyte:S._typhimurium_flagellin 0.18 1114.57
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.37, Monocyte:CD16-: 0.36, Monocyte:anti-FcgRIIB: 0.36, Monocyte:CD14+: 0.35, Monocyte: 0.35, Monocyte:leukotriene_D4: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.35, Neutrophil:commensal_E._coli_MG1655: 0.35, Neutrophil:LPS: 0.35
WK012-I16 Macrophage:monocyte-derived:M-CSF/Pam3Cys 0.23 323.35
Raw ScoresMacrophage:monocyte-derived:M-CSF/Pam3Cys: 0.49, Monocyte:S._typhimurium_flagellin: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48, DC:monocyte-derived:antiCD40/VAF347: 0.47, Monocyte:F._tularensis_novicida: 0.46, Macrophage:monocyte-derived:S._aureus: 0.45, Monocyte:anti-FcgRIIB: 0.45, DC:monocyte-derived:LPS: 0.45, DC:monocyte-derived:Galectin-1: 0.45, Macrophage:Alveolar:B._anthacis_spores: 0.45
TM116-L17 Monocyte:S._typhimurium_flagellin 0.19 266.99
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.37, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.34, Monocyte:F._tularensis_novicida: 0.34, DC:monocyte-derived:antiCD40/VAF347: 0.34, Monocyte:anti-FcgRIIB: 0.34, Monocyte: 0.33, Neutrophil:LPS: 0.33, Monocyte:CD16-: 0.33, Macrophage:monocyte-derived:S._aureus: 0.33
WK021-N6 Monocyte:CD16+ 0.22 237.43
Raw ScoresMonocyte:CD16+: 0.53, Monocyte:CD16-: 0.5, Monocyte:CD14+: 0.5, Monocyte: 0.48, Neutrophil:commensal_E._coli_MG1655: 0.48, Monocyte:leukotriene_D4: 0.48, Neutrophil: 0.48, Neutrophil:uropathogenic_E._coli_UTI89: 0.48, Pre-B_cell_CD34-: 0.47, Monocyte:anti-FcgRIIB: 0.47
TM110-J10 Monocyte:S._typhimurium_flagellin 0.12 229.64
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.3, Neutrophil:commensal_E._coli_MG1655: 0.29, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.29, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.28, Monocyte:anti-FcgRIIB: 0.28, DC:monocyte-derived:antiCD40/VAF347: 0.28, Monocyte:CD16-: 0.28, Monocyte: 0.28, Macrophage:monocyte-derived:S._aureus: 0.28, Monocyte:F._tularensis_novicida: 0.28
TM116-E18 Monocyte:S._typhimurium_flagellin 0.19 222.76
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39, Monocyte:anti-FcgRIIB: 0.39, Monocyte:CD16-: 0.39, Monocyte: 0.38, Monocyte:F._tularensis_novicida: 0.38, Macrophage:monocyte-derived:S._aureus: 0.38, DC:monocyte-derived:antiCD40/VAF347: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg: 0.38
WK024-F16 Monocyte:CD16+ 0.16 213.08
Raw ScoresMonocyte:CD16-: 0.37, Monocyte:CD16+: 0.37, Monocyte:CD14+: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, Monocyte:leukotriene_D4: 0.36, Monocyte: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, Monocyte:anti-FcgRIIB: 0.35, Neutrophil:GM-CSF_IFNg: 0.34, Pre-B_cell_CD34-: 0.34
TM115-J11 Monocyte:S._typhimurium_flagellin 0.19 199.11
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.37, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.35, DC:monocyte-derived:antiCD40/VAF347: 0.34, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.34, Monocyte:F._tularensis_novicida: 0.33, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.33, Macrophage:monocyte-derived:S._aureus: 0.33, Neutrophil:LPS: 0.32, DC:monocyte-derived:LPS: 0.32, Monocyte:anti-FcgRIIB: 0.32
TM116-I14 Monocyte:S._typhimurium_flagellin 0.17 182.99
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.37, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, DC:monocyte-derived:antiCD40/VAF347: 0.35, Macrophage:monocyte-derived:S._aureus: 0.34, Monocyte:anti-FcgRIIB: 0.34, Monocyte:CD16-: 0.34, Monocyte:F._tularensis_novicida: 0.34, Neutrophil:commensal_E._coli_MG1655: 0.34, Monocyte: 0.34
WK016-H12 Monocyte:S._typhimurium_flagellin 0.21 180.38
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41, Monocyte:F._tularensis_novicida: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.39, DC:monocyte-derived:LPS: 0.39, Macrophage:monocyte-derived:S._aureus: 0.39, Monocyte:anti-FcgRIIB: 0.39, Neutrophil:LPS: 0.38, DC:monocyte-derived:Galectin-1: 0.38
WK024-L20 Monocyte:CD16- 0.16 175.74
Raw ScoresMonocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Macrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Monocyte:leukotriene_D4: 0.42, Monocyte: 0.42, Monocyte:CD16+: 0.42, Monocyte:anti-FcgRIIB: 0.41, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.41, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.41
TM110-L17 Monocyte:S._typhimurium_flagellin 0.16 173.63
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.35, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.33, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.32, DC:monocyte-derived:antiCD40/VAF347: 0.32, Monocyte:F._tularensis_novicida: 0.32, Monocyte:anti-FcgRIIB: 0.32, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.32, Macrophage:monocyte-derived:S._aureus: 0.31, Monocyte: 0.31, Neutrophil:commensal_E._coli_MG1655: 0.31
TM111-O19 Monocyte:S._typhimurium_flagellin 0.19 172.71
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.39, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.36, DC:monocyte-derived:antiCD40/VAF347: 0.36, Macrophage:monocyte-derived:S._aureus: 0.35, Monocyte:anti-FcgRIIB: 0.35, Monocyte:F._tularensis_novicida: 0.35, Neutrophil:LPS: 0.34, Neutrophil:GM-CSF_IFNg: 0.34, Monocyte: 0.34
TM39-M23 Monocyte:S._typhimurium_flagellin 0.13 160.97
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.32, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.3, DC:monocyte-derived:antiCD40/VAF347: 0.3, Monocyte:F._tularensis_novicida: 0.3, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.3, Monocyte:anti-FcgRIIB: 0.29, Macrophage:monocyte-derived:S._aureus: 0.29, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.29, Monocyte: 0.29, DC:monocyte-derived:Schuler_treatment: 0.29
WK036-I12 Monocyte:S._typhimurium_flagellin 0.19 153.06
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.4, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, DC:monocyte-derived:antiCD40/VAF347: 0.38, Monocyte:F._tularensis_novicida: 0.38, Macrophage:monocyte-derived:S._aureus: 0.36, DC:monocyte-derived:LPS: 0.36, Macrophage:Alveolar:B._anthacis_spores: 0.36, Monocyte:anti-FcgRIIB: 0.36, Neutrophil:LPS: 0.36
WK024-A19 Macrophage:monocyte-derived:M-CSF/IFNg 0.21 151.89
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.5, Macrophage:monocyte-derived:IL-4/cntrl: 0.5, Macrophage:monocyte-derived:IL-4/TGFb: 0.5, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.5, Macrophage:monocyte-derived:M-CSF: 0.5, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.49, Macrophage:monocyte-derived:IFNa: 0.49, DC:monocyte-derived:AEC-conditioned: 0.48, DC:monocyte-derived: 0.48, Macrophage:monocyte-derived: 0.48
WK021-B15 Monocyte:CD16+ 0.20 143.67
Raw ScoresMonocyte:CD16+: 0.51, Monocyte:CD16-: 0.49, Monocyte:CD14+: 0.48, Monocyte: 0.47, Monocyte:leukotriene_D4: 0.46, Pre-B_cell_CD34-: 0.46, Monocyte:anti-FcgRIIB: 0.46, HSC_-G-CSF: 0.46, Neutrophil:commensal_E._coli_MG1655: 0.46, Neutrophil: 0.46
TM114-A6 Macrophage:monocyte-derived:M-CSF/Pam3Cys 0.07 135.79
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.27, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.26, Monocyte:F._tularensis_novicida: 0.26, DC:monocyte-derived:antiCD40/VAF347: 0.26, Macrophage:monocyte-derived:S._aureus: 0.26, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.25, DC:monocyte-derived:mature: 0.25, Monocyte:anti-FcgRIIB: 0.25, Neutrophil:LPS: 0.25, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.25
TM110-M7 Monocyte:S._typhimurium_flagellin 0.10 135.49
Raw ScoresNeutrophil:commensal_E._coli_MG1655: 0.24, Monocyte:S._typhimurium_flagellin: 0.24, Monocyte:CD16-: 0.24, Neutrophil: 0.23, Neutrophil:uropathogenic_E._coli_UTI89: 0.23, Neutrophil:inflam: 0.23, Monocyte:CD16+: 0.23, Monocyte:CD14+: 0.23, Neutrophil:LPS: 0.23, Monocyte: 0.23
WK014-H3 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.18 135.33
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41, Neutrophil:LPS: 0.4, Neutrophil:GM-CSF_IFNg: 0.39, Monocyte:F._tularensis_novicida: 0.39, Neutrophil:commensal_E._coli_MG1655: 0.39, DC:monocyte-derived:antiCD40/VAF347: 0.39, Monocyte:CD16+: 0.39, Monocyte:CD16-: 0.39
KK051-H13 Monocyte:S._typhimurium_flagellin 0.18 133.64
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:F._tularensis_novicida: 0.39, DC:monocyte-derived:antiCD40/VAF347: 0.38, Neutrophil:LPS: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, DC:monocyte-derived:LPS: 0.37, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.37, Macrophage:Alveolar:B._anthacis_spores: 0.37
WK012-N12 Monocyte:S._typhimurium_flagellin 0.19 131.58
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.39, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.37, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.37, DC:monocyte-derived:antiCD40/VAF347: 0.35, Monocyte:F._tularensis_novicida: 0.35, Neutrophil:LPS: 0.35, DC:monocyte-derived:LPS: 0.34, Macrophage:monocyte-derived:S._aureus: 0.34, Monocyte:anti-FcgRIIB: 0.34, Neutrophil:GM-CSF_IFNg: 0.34
TM112-L1 Monocyte:S._typhimurium_flagellin 0.12 127.43
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.31, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.29, DC:monocyte-derived:antiCD40/VAF347: 0.29, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.29, Monocyte:anti-FcgRIIB: 0.28, Macrophage:monocyte-derived:S._aureus: 0.28, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.28, Monocyte:F._tularensis_novicida: 0.28, DC:monocyte-derived:LPS: 0.27, DC:monocyte-derived:Schuler_treatment: 0.27
TM38-M7 Monocyte:S._typhimurium_flagellin 0.21 123.40
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.44, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, Monocyte:F._tularensis_novicida: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.4, Monocyte:anti-FcgRIIB: 0.39, Macrophage:monocyte-derived:S._aureus: 0.39, Neutrophil:LPS: 0.39, Monocyte: 0.39, Macrophage:Alveolar:B._anthacis_spores: 0.38
TM37-H12 Monocyte:S._typhimurium_flagellin 0.20 120.04
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.39, Monocyte:F._tularensis_novicida: 0.38, Macrophage:Alveolar:B._anthacis_spores: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.37, Monocyte:anti-FcgRIIB: 0.37, DC:monocyte-derived:LPS: 0.37
TM110-L3 Monocyte:S._typhimurium_flagellin 0.14 116.89
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.29, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.27, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.27, Monocyte:anti-FcgRIIB: 0.27, Macrophage:monocyte-derived:S._aureus: 0.27, DC:monocyte-derived:antiCD40/VAF347: 0.27, Monocyte:F._tularensis_novicida: 0.27, Monocyte: 0.27, Monocyte:CD16-: 0.26, Monocyte:leukotriene_D4: 0.26
TM36-O13 Neutrophil:LPS 0.11 112.87
Raw ScoresNeutrophil:commensal_E._coli_MG1655: 0.24, Neutrophil:LPS: 0.23, Neutrophil: 0.22, Neutrophil:GM-CSF_IFNg: 0.22, Neutrophil:uropathogenic_E._coli_UTI89: 0.22, Neutrophil:inflam: 0.22, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.22, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.21, Monocyte:F._tularensis_novicida: 0.21, Monocyte:S._typhimurium_flagellin: 0.21
WK065-B13 Neutrophil:LPS 0.09 112.73
Raw ScoresNeutrophil:commensal_E._coli_MG1655: 0.2, Monocyte:S._typhimurium_flagellin: 0.19, Neutrophil:LPS: 0.19, Neutrophil:uropathogenic_E._coli_UTI89: 0.19, Monocyte:F._tularensis_novicida: 0.19, Neutrophil:inflam: 0.19, Neutrophil:GM-CSF_IFNg: 0.19, Neutrophil: 0.18, Monocyte:anti-FcgRIIB: 0.18, Macrophage:monocyte-derived:S._aureus: 0.18
WK066-P13 Tissue_stem_cells:BM_MSC:BMP2 0.03 106.37
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.15, Tissue_stem_cells:BM_MSC:TGFb3: 0.15, Endothelial_cells:HUVEC:IFNg: 0.15, DC:monocyte-derived:mature: 0.15, Endothelial_cells:lymphatic:TNFa_48h: 0.14, Smooth_muscle_cells:vascular:IL-17: 0.14, Fibroblasts:breast: 0.14, Fibroblasts:foreskin: 0.14, Neutrophil:GM-CSF_IFNg: 0.14, Chondrocytes:MSC-derived: 0.14
TM111-B21 Monocyte:S._typhimurium_flagellin 0.15 104.25
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.3, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.27, Neutrophil:commensal_E._coli_MG1655: 0.27, DC:monocyte-derived:antiCD40/VAF347: 0.27, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.27, Monocyte:F._tularensis_novicida: 0.27, Monocyte:anti-FcgRIIB: 0.26, Neutrophil:LPS: 0.26, Monocyte: 0.26, Macrophage:monocyte-derived:S._aureus: 0.26
WK036-J21 Monocyte:S._typhimurium_flagellin 0.13 102.38
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.32, DC:monocyte-derived:antiCD40/VAF347: 0.3, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.3, Monocyte:F._tularensis_novicida: 0.3, Macrophage:monocyte-derived:S._aureus: 0.29, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.29, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.29, Monocyte:anti-FcgRIIB: 0.28, Macrophage:Alveolar:B._anthacis_spores: 0.28, DC:monocyte-derived:LPS: 0.28
TM116-O7 Monocyte:S._typhimurium_flagellin 0.05 99.04
Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.25, Tissue_stem_cells:BM_MSC:BMP2: 0.25, Fibroblasts:foreskin: 0.24, Smooth_muscle_cells:vascular:IL-17: 0.24, iPS_cells:adipose_stem_cells: 0.24, Osteoblasts: 0.24, Osteoblasts:BMP2: 0.24, Fibroblasts:breast: 0.24, Chondrocytes:MSC-derived: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.24
WK055-O8 Monocyte:S._typhimurium_flagellin 0.15 98.24
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.37, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.36, DC:monocyte-derived:antiCD40/VAF347: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.35, Monocyte:F._tularensis_novicida: 0.34, Macrophage:monocyte-derived:S._aureus: 0.34, DC:monocyte-derived:Schuler_treatment: 0.33, DC:monocyte-derived:LPS: 0.33, DC:monocyte-derived:Galectin-1: 0.33
WK012-P12 Macrophage:monocyte-derived:M-CSF/Pam3Cys 0.19 97.60
Raw ScoresMacrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.42, Monocyte:S._typhimurium_flagellin: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.41, DC:monocyte-derived:LPS: 0.41, Macrophage:monocyte-derived:S._aureus: 0.41, DC:monocyte-derived:Schuler_treatment: 0.41, DC:monocyte-derived:CD40L: 0.4, DC:monocyte-derived:Galectin-1: 0.4
WK100-L15 Monocyte:S._typhimurium_flagellin 0.20 96.17
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39, DC:monocyte-derived:antiCD40/VAF347: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.38, Monocyte:F._tularensis_novicida: 0.38, Macrophage:monocyte-derived:S._aureus: 0.37, Neutrophil:LPS: 0.37, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.36, DC:monocyte-derived:LPS: 0.36, DC:monocyte-derived:Galectin-1: 0.36
TM111-C1 Monocyte:S._typhimurium_flagellin 0.15 94.92
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.33, Monocyte:F._tularensis_novicida: 0.3, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.3, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.3, DC:monocyte-derived:antiCD40/VAF347: 0.3, Monocyte:anti-FcgRIIB: 0.3, Macrophage:monocyte-derived:S._aureus: 0.29, Neutrophil:LPS: 0.29, Neutrophil:GM-CSF_IFNg: 0.29, Macrophage:Alveolar:B._anthacis_spores: 0.29
WK012-G20 Tissue_stem_cells:BM_MSC:TGFb3 0.08 91.36
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.18, Tissue_stem_cells:BM_MSC:TGFb3: 0.17, Fibroblasts:breast: 0.17, Smooth_muscle_cells:vascular:IL-17: 0.17, iPS_cells:adipose_stem_cells: 0.16, Tissue_stem_cells:BM_MSC: 0.16, Osteoblasts: 0.16, Chondrocytes:MSC-derived: 0.16, MSC: 0.16, Osteoblasts:BMP2: 0.16
WK101-M16 Monocyte:S._typhimurium_flagellin 0.22 90.05
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.45, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.42, Monocyte:F._tularensis_novicida: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.41, Macrophage:monocyte-derived:S._aureus: 0.41, DC:monocyte-derived:LPS: 0.41, DC:monocyte-derived:Schuler_treatment: 0.4, DC:monocyte-derived:Galectin-1: 0.4
TM111-K21 Monocyte:S._typhimurium_flagellin 0.15 89.73
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.32, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.31, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.3, DC:monocyte-derived:antiCD40/VAF347: 0.3, Monocyte:F._tularensis_novicida: 0.3, Monocyte:anti-FcgRIIB: 0.3, Neutrophil:LPS: 0.29, Macrophage:monocyte-derived:S._aureus: 0.29, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.29, DC:monocyte-derived:LPS: 0.28
TM116-N15 Neutrophil:commensal_E._coli_MG1655 0.12 88.12
Raw ScoresNeutrophil:commensal_E._coli_MG1655: 0.23, Neutrophil:uropathogenic_E._coli_UTI89: 0.22, Neutrophil:inflam: 0.22, Neutrophil: 0.22, Neutrophil:LPS: 0.22, Neutrophil:GM-CSF_IFNg: 0.21, Monocyte:S._typhimurium_flagellin: 0.2, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.2, Macrophage:monocyte-derived:S._aureus: 0.2, Monocyte:F._tularensis_novicida: 0.2
WMK004-F1 Monocyte:S._typhimurium_flagellin 0.15 87.80
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.3, Monocyte:F._tularensis_novicida: 0.29, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.29, DC:monocyte-derived:antiCD40/VAF347: 0.28, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.28, Neutrophil:LPS: 0.28, Macrophage:monocyte-derived:S._aureus: 0.27, Neutrophil:commensal_E._coli_MG1655: 0.27, DC:monocyte-derived:LPS: 0.27, Monocyte:anti-FcgRIIB: 0.27
TM110-H15 Monocyte:CD16- 0.06 87.27
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.19, Monocyte:S._typhimurium_flagellin: 0.18, Monocyte:leukotriene_D4: 0.18, Monocyte:anti-FcgRIIB: 0.18, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.18, Monocyte: 0.18, Macrophage:monocyte-derived:S._aureus: 0.18, Monocyte:CD16-: 0.18, Macrophage:monocyte-derived:M-CSF: 0.18, DC:monocyte-derived:Galectin-1: 0.17
TM114-J13 Monocyte:S._typhimurium_flagellin 0.10 85.75
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.26, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.24, DC:monocyte-derived:antiCD40/VAF347: 0.24, Macrophage:monocyte-derived:S._aureus: 0.24, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.24, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.23, Monocyte:anti-FcgRIIB: 0.23, Neutrophil:LPS: 0.23, Macrophage:Alveolar:B._anthacis_spores: 0.23, Monocyte:F._tularensis_novicida: 0.23
KK054-E6 Monocyte:S._typhimurium_flagellin 0.16 83.48
Raw ScoresMacrophage:monocyte-derived:M-CSF/Pam3Cys: 0.35, Monocyte:S._typhimurium_flagellin: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.34, Monocyte:F._tularensis_novicida: 0.34, DC:monocyte-derived:antiCD40/VAF347: 0.33, Monocyte:anti-FcgRIIB: 0.32, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.32, DC:monocyte-derived:LPS: 0.31, DC:monocyte-derived:Galectin-1: 0.31, Macrophage:monocyte-derived:S._aureus: 0.31
TM116-M22 Macrophage:monocyte-derived:M-CSF/Pam3Cys 0.10 83.20
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.24, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.24, DC:monocyte-derived:antiCD40/VAF347: 0.24, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.23, Macrophage:monocyte-derived:S._aureus: 0.23, DC:monocyte-derived:LPS: 0.23, Monocyte:F._tularensis_novicida: 0.23, DC:monocyte-derived:Galectin-1: 0.23, Monocyte:anti-FcgRIIB: 0.22, DC:monocyte-derived:Schuler_treatment: 0.22
TM111-K15 Monocyte:S._typhimurium_flagellin 0.13 81.78
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.27, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.27, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.26, DC:monocyte-derived:antiCD40/VAF347: 0.26, Monocyte:anti-FcgRIIB: 0.26, Neutrophil:LPS: 0.25, Macrophage:monocyte-derived:S._aureus: 0.25, Neutrophil:GM-CSF_IFNg: 0.25, Monocyte:F._tularensis_novicida: 0.25, Neutrophil:commensal_E._coli_MG1655: 0.25
WK096-O9 Monocyte:S._typhimurium_flagellin 0.16 78.52
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.35, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.34, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.33, Monocyte:F._tularensis_novicida: 0.33, DC:monocyte-derived:antiCD40/VAF347: 0.32, Monocyte:anti-FcgRIIB: 0.32, DC:monocyte-derived:LPS: 0.32, Monocyte: 0.32, Monocyte:CD16-: 0.31, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.31
TM37-F9 Smooth_muscle_cells:bronchial 0.17 78.42
Raw ScoresSmooth_muscle_cells:bronchial: 0.36, Smooth_muscle_cells:bronchial:vit_D: 0.36, Fibroblasts:breast: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, iPS_cells:adipose_stem_cells: 0.35, iPS_cells:CRL2097_foreskin: 0.35, Osteoblasts: 0.35, Chondrocytes:MSC-derived: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Smooth_muscle_cells:vascular: 0.34
TM114-E12 Monocyte:S._typhimurium_flagellin 0.15 73.51
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.35, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.34, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.34, DC:monocyte-derived:antiCD40/VAF347: 0.33, DC:monocyte-derived:LPS: 0.33, Monocyte: 0.33, Monocyte:anti-FcgRIIB: 0.33, Macrophage:monocyte-derived:S._aureus: 0.33, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.33, Monocyte:leukotriene_D4: 0.32
KK059-G22 Monocyte:CD16- 0.13 72.11
Raw ScoresMonocyte:CD16-: 0.37, Monocyte:CD14+: 0.37, Monocyte:CD16+: 0.37, Monocyte: 0.37, Monocyte:leukotriene_D4: 0.36, Monocyte:anti-FcgRIIB: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Macrophage:monocyte-derived:M-CSF: 0.35, Pre-B_cell_CD34-: 0.35, DC:monocyte-derived:AEC-conditioned: 0.35


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.47e-03
Mean rank of genes in gene set: 629.67
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
S100A10 0.0046091 107 GTEx DepMap Descartes 2.47 2673.04
IFITM3 0.0044052 122 GTEx DepMap Descartes 7.22 9266.29
B2M 0.0003463 1660 GTEx DepMap Descartes 26.84 5298.64


p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.02e-02
Mean rank of genes in gene set: 338
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NEAT1 0.0066856 54 GTEx DepMap Descartes 34.54 1129.58
CDKN1A 0.0013667 622 GTEx DepMap Descartes 3.50 1104.73


IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.10e-02
Mean rank of genes in gene set: 2562.2
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ISG15 0.0033634 189 GTEx DepMap Descartes 0.82 1147.67
IFIT3 0.0007827 1010 GTEx DepMap Descartes 0.20 85.18
ISG20 0.0004383 1473 GTEx DepMap Descartes 0.34 54.31
IFIT1 0.0000545 2694 GTEx DepMap Descartes 0.04 14.31
IFIT2 -0.0003539 7445 GTEx DepMap Descartes 0.08 9.00




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8530.16
Median rank of genes in gene set: 9347
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LYN 0.0060601 62 GTEx DepMap Descartes 1.54 146.09
GCH1 0.0029311 229 GTEx DepMap Descartes 1.23 280.56
ATP6V1B2 0.0029241 230 GTEx DepMap Descartes 2.76 175.72
CDC42EP3 0.0021008 379 GTEx DepMap Descartes 1.69 185.14
HMGA1 0.0017246 492 GTEx DepMap Descartes 0.69 203.53
EIF1B 0.0016423 517 GTEx DepMap Descartes 0.66 429.45
FOXO3 0.0016295 521 GTEx DepMap Descartes 1.30 111.12
AP1S2 0.0013934 606 GTEx DepMap Descartes 0.64 79.64
HK2 0.0012287 696 GTEx DepMap Descartes 0.18 18.64
UCP2 0.0006791 1116 GTEx DepMap Descartes 0.72 105.90
NGRN 0.0006410 1174 GTEx DepMap Descartes 0.07 14.30
RALGDS 0.0006212 1191 GTEx DepMap Descartes 0.78 72.35
RTN2 0.0005615 1270 GTEx DepMap Descartes 0.07 29.91
FBXO8 0.0005379 1298 GTEx DepMap Descartes 0.04 34.66
ACVR1B 0.0005203 1332 GTEx DepMap Descartes 0.16 22.54
ANP32A 0.0005106 1352 GTEx DepMap Descartes 0.31 58.77
CD200 0.0004989 1371 GTEx DepMap Descartes 0.09 50.13
AGTPBP1 0.0004462 1459 GTEx DepMap Descartes 0.15 12.44
DIABLO 0.0004386 1472 GTEx DepMap Descartes 0.01 3.01
ESRRG 0.0002945 1774 GTEx DepMap Descartes 0.00 0.00
GNB1 0.0002848 1802 GTEx DepMap Descartes 1.16 207.56
FAM107B 0.0002360 1947 GTEx DepMap Descartes 0.72 143.76
UNC79 0.0001383 2296 GTEx DepMap Descartes 0.01 1.46
REC8 0.0001274 2345 GTEx DepMap Descartes 0.12 40.22
IRS2 0.0000616 2658 GTEx DepMap Descartes 0.47 44.70
PTS 0.0000490 2715 GTEx DepMap Descartes 0.12 100.15
NARS2 0.0000419 2757 GTEx DepMap Descartes 0.01 3.25
ACOT7 0.0000328 2809 GTEx DepMap Descartes 0.14 87.87
KIF15 0.0000002 3006 GTEx DepMap Descartes 0.00 0.00
DTD1 -0.0000340 3230 GTEx DepMap Descartes 0.08 16.94


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 7053.49
Median rank of genes in gene set: 7906
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ATP2B1 0.0101817 13 GTEx DepMap Descartes 4.99 447.68
TIMP1 0.0071152 42 GTEx DepMap Descartes 20.96 12739.31
THBS1 0.0059913 65 GTEx DepMap Descartes 13.89 1155.57
FNDC3B 0.0051457 88 GTEx DepMap Descartes 1.85 160.58
ASPH 0.0050420 91 GTEx DepMap Descartes 0.92 146.81
SDCBP 0.0050113 93 GTEx DepMap Descartes 4.61 751.40
IFITM2 0.0044422 120 GTEx DepMap Descartes 5.07 5814.61
DSE 0.0044390 121 GTEx DepMap Descartes 1.32 96.33
IFITM3 0.0044052 122 GTEx DepMap Descartes 7.22 9266.29
GRN 0.0043722 123 GTEx DepMap Descartes 5.03 837.30
RIN2 0.0042353 130 GTEx DepMap Descartes 0.50 67.17
CD44 0.0040498 139 GTEx DepMap Descartes 10.65 1081.31
PLSCR1 0.0037937 156 GTEx DepMap Descartes 0.86 248.42
ANXA5 0.0037643 159 GTEx DepMap Descartes 6.90 2311.51
ARPC1B 0.0033541 190 GTEx DepMap Descartes 0.99 251.83
RAB31 0.0033177 193 GTEx DepMap Descartes 1.30 184.88
CKAP4 0.0031205 212 GTEx DepMap Descartes 0.49 166.72
MGST1 0.0030194 217 GTEx DepMap Descartes 0.20 74.70
CMTM6 0.0029502 228 GTEx DepMap Descartes 2.51 419.31
FLNA 0.0028529 237 GTEx DepMap Descartes 3.36 243.24
QSOX1 0.0027996 246 GTEx DepMap Descartes 0.36 23.40
DUSP6 0.0026870 265 GTEx DepMap Descartes 2.12 422.75
RAP1B 0.0024028 312 GTEx DepMap Descartes 0.95 42.61
ANXA2 0.0023558 320 GTEx DepMap Descartes 3.97 576.59
CD63 0.0023381 324 GTEx DepMap Descartes 3.66 1607.10
GNS 0.0023327 326 GTEx DepMap Descartes 1.46 137.14
ACTN1 0.0023052 337 GTEx DepMap Descartes 1.14 238.05
CTSB 0.0022951 340 GTEx DepMap Descartes 6.81 748.74
LITAF 0.0022897 341 GTEx DepMap Descartes 6.09 1426.18
CYFIP1 0.0019937 412 GTEx DepMap Descartes 0.64 68.97


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.53e-01
Mean rank of genes in gene set: 6048.08
Median rank of genes in gene set: 5709.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
POR 0.0023105 335 GTEx DepMap Descartes 0.51 105.73
SH3BP5 0.0017794 471 GTEx DepMap Descartes 0.68 168.41
PAPSS2 0.0012712 677 GTEx DepMap Descartes 0.47 43.26
NPC1 0.0007898 1005 GTEx DepMap Descartes 0.51 62.29
GRAMD1B 0.0006696 1133 GTEx DepMap Descartes 0.16 13.12
LDLR 0.0004552 1446 GTEx DepMap Descartes 0.35 51.13
ERN1 0.0001499 2256 GTEx DepMap Descartes 0.39 48.24
FDXR 0.0000779 2578 GTEx DepMap Descartes 0.03 1.33
TM7SF2 0.0000400 2767 GTEx DepMap Descartes 0.01 4.85
APOC1 -0.0000155 3094 GTEx DepMap Descartes 2.52 319.04
FDPS -0.0000582 3437 GTEx DepMap Descartes 0.15 39.94
STAR -0.0000937 3835 GTEx DepMap Descartes 0.00 0.00
FREM2 -0.0001059 3968 GTEx DepMap Descartes 0.01 0.10
FDX1 -0.0001189 4138 GTEx DepMap Descartes 0.24 20.46
PDE10A -0.0001447 4475 GTEx DepMap Descartes 0.01 2.82
SGCZ -0.0001477 4515 GTEx DepMap Descartes 0.00 0.00
SH3PXD2B -0.0001607 4705 GTEx DepMap Descartes 0.07 5.43
SLC1A2 -0.0002240 5591 GTEx DepMap Descartes 0.03 1.14
INHA -0.0002415 5828 GTEx DepMap Descartes 0.00 0.00
DHCR7 -0.0002803 6367 GTEx DepMap Descartes 0.07 32.39
SLC16A9 -0.0003456 7324 GTEx DepMap Descartes 0.00 0.00
SCARB1 -0.0003561 7475 GTEx DepMap Descartes 0.05 0.91
BAIAP2L1 -0.0003745 7740 GTEx DepMap Descartes 0.00 0.00
DNER -0.0003975 8080 GTEx DepMap Descartes 0.00 0.00
JAKMIP2 -0.0004079 8231 GTEx DepMap Descartes 0.04 2.01
GSTA4 -0.0004513 8785 GTEx DepMap Descartes 0.03 7.08
FRMD5 -0.0004566 8857 GTEx DepMap Descartes 0.00 0.00
DHCR24 -0.0004628 8944 GTEx DepMap Descartes 0.00 0.00
IGF1R -0.0005517 9910 GTEx DepMap Descartes 0.03 1.67
CYB5B -0.0006413 10703 GTEx DepMap Descartes 0.14 12.88


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8434.24
Median rank of genes in gene set: 8164
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BASP1 0.0097931 16 GTEx DepMap Descartes 6.84 2381.65
SLC6A2 0.0003239 1708 GTEx DepMap Descartes 0.01 1.77
GAL -0.0000916 3801 GTEx DepMap Descartes 0.00 0.00
GREM1 -0.0001410 4428 GTEx DepMap Descartes 0.04 5.85
NPY -0.0001905 5107 GTEx DepMap Descartes 0.20 139.00
RPH3A -0.0002041 5314 GTEx DepMap Descartes 0.00 0.00
KCNB2 -0.0002049 5331 GTEx DepMap Descartes 0.00 0.00
NTRK1 -0.0002551 6010 GTEx DepMap Descartes 0.01 1.15
EPHA6 -0.0002639 6145 GTEx DepMap Descartes 0.00 0.00
IL7 -0.0002713 6256 GTEx DepMap Descartes 0.00 0.00
RBFOX1 -0.0002813 6384 GTEx DepMap Descartes 0.00 0.00
HS3ST5 -0.0003463 7337 GTEx DepMap Descartes 0.00 0.00
ANKFN1 -0.0003494 7383 GTEx DepMap Descartes 0.00 0.00
REEP1 -0.0003498 7388 GTEx DepMap Descartes 0.03 4.46
TMEFF2 -0.0003562 7477 GTEx DepMap Descartes 0.00 0.00
EYA1 -0.0003576 7502 GTEx DepMap Descartes 0.00 0.00
EYA4 -0.0003598 7541 GTEx DepMap Descartes 0.00 0.00
CNTFR -0.0003719 7704 GTEx DepMap Descartes 0.00 0.00
PLXNA4 -0.0003729 7713 GTEx DepMap Descartes 0.00 0.00
ALK -0.0004009 8146 GTEx DepMap Descartes 0.00 0.00
FAT3 -0.0004020 8164 GTEx DepMap Descartes 0.00 0.00
SLC44A5 -0.0004394 8653 GTEx DepMap Descartes 0.00 0.00
TMEM132C -0.0004671 8994 GTEx DepMap Descartes 0.00 0.00
RYR2 -0.0004802 9152 GTEx DepMap Descartes 0.00 0.00
SYNPO2 -0.0005064 9459 GTEx DepMap Descartes 0.19 5.54
MAB21L2 -0.0005314 9705 GTEx DepMap Descartes 0.00 0.00
CNKSR2 -0.0006003 10361 GTEx DepMap Descartes 0.00 0.00
PTCHD1 -0.0006033 10396 GTEx DepMap Descartes 0.00 0.00
MARCH11 -0.0006233 10558 GTEx DepMap Descartes 0.00 NA
ISL1 -0.0006544 10809 GTEx DepMap Descartes 0.07 11.55


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.83e-01
Mean rank of genes in gene set: 6398.61
Median rank of genes in gene set: 6738
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMEM88 0.0002237 1987 GTEx DepMap Descartes 0.22 148.07
CEACAM1 0.0002229 1989 GTEx DepMap Descartes 0.04 12.31
F8 0.0000747 2598 GTEx DepMap Descartes 0.01 0.11
TIE1 -0.0000042 3033 GTEx DepMap Descartes 0.07 17.62
CHRM3 -0.0000633 3492 GTEx DepMap Descartes 0.00 0.00
NPR1 -0.0000853 3726 GTEx DepMap Descartes 0.01 2.46
CDH13 -0.0000908 3791 GTEx DepMap Descartes 0.04 5.10
NR5A2 -0.0000940 3842 GTEx DepMap Descartes 0.00 0.00
MMRN2 -0.0000999 3900 GTEx DepMap Descartes 0.04 12.13
BTNL9 -0.0001313 4303 GTEx DepMap Descartes 0.00 0.00
NOTCH4 -0.0001559 4636 GTEx DepMap Descartes 0.09 4.43
FLT4 -0.0001595 4688 GTEx DepMap Descartes 0.03 2.29
CRHBP -0.0002008 5266 GTEx DepMap Descartes 0.01 0.60
ESM1 -0.0002144 5466 GTEx DepMap Descartes 0.00 0.00
CLDN5 -0.0002174 5510 GTEx DepMap Descartes 0.00 0.00
KANK3 -0.0002380 5778 GTEx DepMap Descartes 0.00 0.00
TEK -0.0002632 6135 GTEx DepMap Descartes 0.00 0.00
EHD3 -0.0002885 6479 GTEx DepMap Descartes 0.03 2.64
PTPRB -0.0002929 6545 GTEx DepMap Descartes 0.03 1.01
CDH5 -0.0003198 6931 GTEx DepMap Descartes 0.00 0.00
PODXL -0.0003310 7118 GTEx DepMap Descartes 0.00 0.00
SHE -0.0003325 7142 GTEx DepMap Descartes 0.00 0.00
IRX3 -0.0003372 7215 GTEx DepMap Descartes 0.00 0.00
KDR -0.0003375 7221 GTEx DepMap Descartes 0.00 0.00
ROBO4 -0.0003434 7297 GTEx DepMap Descartes 0.03 1.03
SLCO2A1 -0.0003470 7348 GTEx DepMap Descartes 0.01 2.01
MYRIP -0.0003516 7418 GTEx DepMap Descartes 0.00 0.00
GALNT15 -0.0003749 7748 GTEx DepMap Descartes 0.00 NA
PLVAP -0.0003907 7981 GTEx DepMap Descartes 0.07 7.46
RASIP1 -0.0004000 8133 GTEx DepMap Descartes 0.01 0.48


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 8002.86
Median rank of genes in gene set: 8164
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GLI2 0.0001985 2069 GTEx DepMap Descartes 0.01 5.77
MGP 0.0000775 2580 GTEx DepMap Descartes 2.64 1374.67
ADAMTSL3 0.0000413 2762 GTEx DepMap Descartes 0.05 7.29
COL27A1 0.0000301 2822 GTEx DepMap Descartes 0.04 2.01
SFRP2 -0.0001532 4594 GTEx DepMap Descartes 0.15 114.74
DKK2 -0.0001749 4891 GTEx DepMap Descartes 0.00 0.00
ADAMTS2 -0.0001857 5038 GTEx DepMap Descartes 0.11 17.92
GAS2 -0.0002002 5258 GTEx DepMap Descartes 0.00 0.00
LAMC3 -0.0002023 5288 GTEx DepMap Descartes 0.00 0.00
CCDC80 -0.0002288 5660 GTEx DepMap Descartes 0.70 49.08
RSPO3 -0.0002521 5964 GTEx DepMap Descartes 0.01 NA
ELN -0.0002531 5975 GTEx DepMap Descartes 0.08 31.36
CLDN11 -0.0002841 6419 GTEx DepMap Descartes 0.01 0.36
LOX -0.0003086 6772 GTEx DepMap Descartes 0.11 13.30
IGFBP3 -0.0003216 6960 GTEx DepMap Descartes 0.04 18.84
FREM1 -0.0003229 6982 GTEx DepMap Descartes 0.00 0.00
ITGA11 -0.0003504 7400 GTEx DepMap Descartes 0.14 4.45
LRRC17 -0.0003533 7438 GTEx DepMap Descartes 0.00 0.00
SCARA5 -0.0003634 7591 GTEx DepMap Descartes 0.07 7.90
ISLR -0.0003785 7794 GTEx DepMap Descartes 0.14 45.59
ABCA6 -0.0003910 7985 GTEx DepMap Descartes 0.08 3.04
ACTA2 -0.0003943 8032 GTEx DepMap Descartes 0.46 252.90
HHIP -0.0004127 8296 GTEx DepMap Descartes 0.00 0.00
POSTN -0.0004222 8411 GTEx DepMap Descartes 0.03 4.26
PDGFRA -0.0004284 8505 GTEx DepMap Descartes 0.01 2.97
ABCC9 -0.0004524 8805 GTEx DepMap Descartes 0.01 1.51
COL1A1 -0.0004541 8827 GTEx DepMap Descartes 8.02 946.96
C7 -0.0004590 8892 GTEx DepMap Descartes 1.67 169.14
PRRX1 -0.0005215 9613 GTEx DepMap Descartes 0.08 32.89
COL3A1 -0.0005253 9654 GTEx DepMap Descartes 2.72 428.42


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.40e-01
Mean rank of genes in gene set: 6653.34
Median rank of genes in gene set: 6144.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GCH1 0.0029311 229 GTEx DepMap Descartes 1.23 280.56
GRM7 0.0000520 2705 GTEx DepMap Descartes 0.01 0.55
PENK -0.0000430 3304 GTEx DepMap Descartes 0.00 0.00
CDH12 -0.0000658 3518 GTEx DepMap Descartes 0.00 0.00
TBX20 -0.0000924 3810 GTEx DepMap Descartes 0.00 0.00
GALNTL6 -0.0001122 4050 GTEx DepMap Descartes 0.00 0.00
SLC35F3 -0.0001215 4178 GTEx DepMap Descartes 0.00 0.00
CDH18 -0.0001230 4199 GTEx DepMap Descartes 0.00 0.00
LAMA3 -0.0001428 4450 GTEx DepMap Descartes 0.01 1.48
SPOCK3 -0.0001448 4477 GTEx DepMap Descartes 0.00 0.00
KSR2 -0.0001581 4664 GTEx DepMap Descartes 0.03 0.63
PACRG -0.0001849 5030 GTEx DepMap Descartes 0.00 0.00
FGF14 -0.0001992 5244 GTEx DepMap Descartes 0.00 0.00
AGBL4 -0.0002185 5524 GTEx DepMap Descartes 0.00 0.00
SLC24A2 -0.0002251 5607 GTEx DepMap Descartes 0.00 0.00
GRID2 -0.0002301 5676 GTEx DepMap Descartes 0.00 0.00
SORCS3 -0.0002301 5677 GTEx DepMap Descartes 0.00 0.00
ARC -0.0002411 5823 GTEx DepMap Descartes 0.09 36.00
CNTN3 -0.0002618 6108 GTEx DepMap Descartes 0.00 0.00
PCSK2 -0.0002665 6181 GTEx DepMap Descartes 0.03 2.59
SLC18A1 -0.0002816 6388 GTEx DepMap Descartes 0.01 1.59
ST18 -0.0002913 6525 GTEx DepMap Descartes 0.05 3.07
TIAM1 -0.0003435 7301 GTEx DepMap Descartes 0.28 21.58
DGKK -0.0003676 7642 GTEx DepMap Descartes 0.00 0.00
EML6 -0.0003755 7756 GTEx DepMap Descartes 0.00 0.00
CCSER1 -0.0003788 7804 GTEx DepMap Descartes 0.01 NA
MGAT4C -0.0004242 8440 GTEx DepMap Descartes 0.03 0.65
ROBO1 -0.0004666 8986 GTEx DepMap Descartes 0.01 1.04
NTNG1 -0.0004755 9094 GTEx DepMap Descartes 0.01 0.74
FAM155A -0.0004806 9154 GTEx DepMap Descartes 0.00 0.00


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.21e-01
Mean rank of genes in gene set: 6481.17
Median rank of genes in gene set: 6033
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC25A37 0.0087952 23 GTEx DepMap Descartes 2.12 303.21
RAPGEF2 0.0008159 971 GTEx DepMap Descartes 0.88 49.15
BLVRB 0.0007296 1071 GTEx DepMap Descartes 0.38 124.28
SOX6 0.0002413 1926 GTEx DepMap Descartes 0.07 12.30
SPTB 0.0000204 2885 GTEx DepMap Descartes 0.03 0.83
SLC25A21 -0.0000465 3332 GTEx DepMap Descartes 0.00 0.00
MICAL2 -0.0000518 3371 GTEx DepMap Descartes 0.14 16.71
RHD -0.0000798 3662 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000890 3768 GTEx DepMap Descartes 0.00 0.00
TFR2 -0.0000935 3828 GTEx DepMap Descartes 0.01 2.77
ALAS2 -0.0001977 5222 GTEx DepMap Descartes 0.00 0.00
TMCC2 -0.0002000 5256 GTEx DepMap Descartes 0.00 0.00
SPECC1 -0.0002135 5450 GTEx DepMap Descartes 0.03 1.66
FECH -0.0002232 5583 GTEx DepMap Descartes 0.04 1.89
GCLC -0.0002566 6033 GTEx DepMap Descartes 0.23 22.08
ANK1 -0.0002874 6465 GTEx DepMap Descartes 0.01 4.62
CAT -0.0002895 6496 GTEx DepMap Descartes 0.22 24.46
RGS6 -0.0003266 7040 GTEx DepMap Descartes 0.00 0.00
XPO7 -0.0004045 8192 GTEx DepMap Descartes 0.04 5.64
TRAK2 -0.0004375 8630 GTEx DepMap Descartes 0.14 5.72
ABCB10 -0.0004600 8910 GTEx DepMap Descartes 0.00 0.00
SNCA -0.0004923 9298 GTEx DepMap Descartes 0.03 3.96
MARCH3 -0.0005890 10262 GTEx DepMap Descartes 0.01 NA
SELENBP1 -0.0006090 10436 GTEx DepMap Descartes 0.01 1.66
CPOX -0.0007209 11214 GTEx DepMap Descartes 0.01 1.13
TSPAN5 -0.0008509 11769 GTEx DepMap Descartes 0.00 0.00
EPB41 -0.0009885 12116 GTEx DepMap Descartes 0.01 0.36
DENND4A -0.0011897 12358 GTEx DepMap Descartes 0.34 14.76
GYPC -0.0012176 12387 GTEx DepMap Descartes 0.11 28.76
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.21e-05
Mean rank of genes in gene set: 3929.5
Median rank of genes in gene set: 1087.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CTSS 0.0109714 10 GTEx DepMap Descartes 6.07 692.01
HCK 0.0094421 18 GTEx DepMap Descartes 2.47 552.37
CYBB 0.0073112 38 GTEx DepMap Descartes 1.82 229.94
PTPRE 0.0042346 131 GTEx DepMap Descartes 0.84 97.90
CD163 0.0041206 136 GTEx DepMap Descartes 0.81 114.36
FGD2 0.0038659 149 GTEx DepMap Descartes 0.23 16.04
CD14 0.0036960 163 GTEx DepMap Descartes 1.26 472.60
CPVL 0.0028787 234 GTEx DepMap Descartes 1.27 215.48
CST3 0.0025752 284 GTEx DepMap Descartes 7.81 986.39
CTSB 0.0022951 340 GTEx DepMap Descartes 6.81 748.74
MARCH1 0.0022646 346 GTEx DepMap Descartes 0.22 NA
MS4A4A 0.0015131 551 GTEx DepMap Descartes 0.64 190.94
CTSD 0.0014590 577 GTEx DepMap Descartes 3.19 635.56
SFMBT2 0.0013558 628 GTEx DepMap Descartes 0.50 38.72
CSF1R 0.0011333 730 GTEx DepMap Descartes 0.69 51.36
TGFBI 0.0009117 884 GTEx DepMap Descartes 1.20 141.59
ABCA1 0.0008403 942 GTEx DepMap Descartes 0.93 49.09
RGL1 0.0008073 982 GTEx DepMap Descartes 0.28 20.86
FGL2 0.0007720 1019 GTEx DepMap Descartes 1.80 137.34
CD74 0.0006535 1156 GTEx DepMap Descartes 44.97 4745.97
ATP8B4 0.0005120 1349 GTEx DepMap Descartes 0.16 11.34
FMN1 0.0004220 1516 GTEx DepMap Descartes 0.08 2.39
ADAP2 0.0002834 1808 GTEx DepMap Descartes 0.08 14.16
IFNGR1 0.0000063 2968 GTEx DepMap Descartes 0.50 47.87
CTSC -0.0000194 3118 GTEx DepMap Descartes 1.30 64.78
HRH1 -0.0003366 7205 GTEx DepMap Descartes 0.04 3.38
RBPJ -0.0003709 7683 GTEx DepMap Descartes 0.69 69.03
SLC1A3 -0.0003744 7739 GTEx DepMap Descartes 0.16 12.26
ITPR2 -0.0003782 7790 GTEx DepMap Descartes 0.31 10.66
CD163L1 -0.0004394 8654 GTEx DepMap Descartes 0.00 0.00


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7813.41
Median rank of genes in gene set: 8989.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCKS 0.0060359 63 GTEx DepMap Descartes 7.70 975.94
VCAN 0.0059931 64 GTEx DepMap Descartes 3.24 249.53
COL25A1 0.0014929 560 GTEx DepMap Descartes 0.01 5.77
VIM 0.0012212 700 GTEx DepMap Descartes 13.14 2837.83
GAS7 0.0003692 1614 GTEx DepMap Descartes 0.43 30.96
HMGA2 0.0001797 2137 GTEx DepMap Descartes 0.01 0.43
IL1RAPL1 -0.0000114 3067 GTEx DepMap Descartes 0.00 0.00
IL1RAPL2 -0.0001058 3967 GTEx DepMap Descartes 0.00 0.00
KCTD12 -0.0001746 4885 GTEx DepMap Descartes 0.50 53.04
LRRTM4 -0.0001935 5159 GTEx DepMap Descartes 0.00 0.00
ADAMTS5 -0.0001948 5179 GTEx DepMap Descartes 0.00 0.00
ERBB4 -0.0002294 5669 GTEx DepMap Descartes 0.00 0.00
TRPM3 -0.0002468 5900 GTEx DepMap Descartes 0.01 0.72
MPZ -0.0002494 5928 GTEx DepMap Descartes 0.00 0.00
EGFLAM -0.0002661 6172 GTEx DepMap Descartes 0.05 14.34
ERBB3 -0.0002986 6627 GTEx DepMap Descartes 0.01 2.29
MDGA2 -0.0003303 7106 GTEx DepMap Descartes 0.00 0.00
PTN -0.0003860 7906 GTEx DepMap Descartes 0.00 0.00
PTPRZ1 -0.0003990 8115 GTEx DepMap Descartes 0.00 0.00
FIGN -0.0004265 8473 GTEx DepMap Descartes 0.01 0.24
XKR4 -0.0004376 8632 GTEx DepMap Descartes 0.03 0.51
SLC35F1 -0.0004538 8820 GTEx DepMap Descartes 0.00 0.00
GRIK3 -0.0004810 9159 GTEx DepMap Descartes 0.00 0.00
PAG1 -0.0004966 9352 GTEx DepMap Descartes 0.84 30.89
PLCE1 -0.0005485 9876 GTEx DepMap Descartes 0.00 0.00
GFRA3 -0.0005503 9892 GTEx DepMap Descartes 0.00 0.00
SOX5 -0.0005545 9932 GTEx DepMap Descartes 0.00 0.00
NRXN1 -0.0005619 10005 GTEx DepMap Descartes 0.03 4.35
NRXN3 -0.0005854 10229 GTEx DepMap Descartes 0.00 0.00
PLP1 -0.0006089 10435 GTEx DepMap Descartes 0.00 0.00


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.42e-03
Mean rank of genes in gene set: 4665.78
Median rank of genes in gene set: 3722
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ACTB 0.0074942 33 GTEx DepMap Descartes 22.72 5151.21
THBS1 0.0059913 65 GTEx DepMap Descartes 13.89 1155.57
PLEK 0.0059477 67 GTEx DepMap Descartes 4.31 1057.75
LIMS1 0.0051348 89 GTEx DepMap Descartes 2.31 364.40
FERMT3 0.0045526 111 GTEx DepMap Descartes 0.99 229.10
ZYX 0.0037414 161 GTEx DepMap Descartes 2.32 589.26
PSTPIP2 0.0032173 203 GTEx DepMap Descartes 0.45 72.76
FLNA 0.0028529 237 GTEx DepMap Descartes 3.36 243.24
SLC2A3 0.0027637 251 GTEx DepMap Descartes 1.86 377.85
RAP1B 0.0024028 312 GTEx DepMap Descartes 0.95 42.61
ACTN1 0.0023052 337 GTEx DepMap Descartes 1.14 238.05
MCTP1 0.0017348 486 GTEx DepMap Descartes 0.54 41.86
TLN1 0.0014366 591 GTEx DepMap Descartes 1.09 80.92
TPM4 0.0012957 659 GTEx DepMap Descartes 1.19 174.87
TUBB1 0.0005841 1238 GTEx DepMap Descartes 0.27 202.73
P2RX1 0.0004595 1438 GTEx DepMap Descartes 0.07 5.19
ITGA2B 0.0004176 1524 GTEx DepMap Descartes 0.07 39.15
SLC24A3 0.0002784 1822 GTEx DepMap Descartes 0.00 0.00
GP1BA 0.0002492 1908 GTEx DepMap Descartes 0.01 20.06
TGFB1 0.0002345 1957 GTEx DepMap Descartes 0.53 162.97
HIPK2 0.0001696 2177 GTEx DepMap Descartes 0.50 13.91
RAB27B 0.0001398 2292 GTEx DepMap Descartes 0.03 9.61
MMRN1 -0.0000852 3722 GTEx DepMap Descartes 0.01 6.45
TRPC6 -0.0000987 3889 GTEx DepMap Descartes 0.00 0.00
MED12L -0.0001176 4118 GTEx DepMap Descartes 0.01 2.34
STON2 -0.0001494 4544 GTEx DepMap Descartes 0.01 1.17
ITGB3 -0.0002432 5852 GTEx DepMap Descartes 0.00 0.00
FLI1 -0.0002773 6322 GTEx DepMap Descartes 0.14 13.62
ARHGAP6 -0.0003202 6938 GTEx DepMap Descartes 0.00 0.00
ANGPT1 -0.0003285 7081 GTEx DepMap Descartes 0.00 0.00


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8483.69
Median rank of genes in gene set: 10883.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LCP1 0.0047400 100 GTEx DepMap Descartes 4.31 586.25
CD44 0.0040498 139 GTEx DepMap Descartes 10.65 1081.31
TMSB10 0.0030211 216 GTEx DepMap Descartes 9.31 9274.25
MCTP2 0.0023284 329 GTEx DepMap Descartes 0.18 17.06
MSN 0.0021961 362 GTEx DepMap Descartes 1.84 242.09
DOCK10 0.0006909 1106 GTEx DepMap Descartes 0.24 25.10
SKAP1 0.0006736 1127 GTEx DepMap Descartes 0.04 11.21
SP100 0.0006528 1158 GTEx DepMap Descartes 0.54 87.70
CCND3 0.0004657 1425 GTEx DepMap Descartes 0.16 59.92
B2M 0.0003463 1660 GTEx DepMap Descartes 26.84 5298.64
RCSD1 -0.0001919 5126 GTEx DepMap Descartes 0.20 14.64
SORL1 -0.0003199 6932 GTEx DepMap Descartes 0.51 16.73
RAP1GAP2 -0.0003778 7785 GTEx DepMap Descartes 0.08 6.68
PTPRC -0.0003855 7900 GTEx DepMap Descartes 2.28 187.24
SAMD3 -0.0004381 8639 GTEx DepMap Descartes 0.00 0.00
ANKRD44 -0.0004496 8768 GTEx DepMap Descartes 0.18 15.80
ARHGDIB -0.0005219 9619 GTEx DepMap Descartes 2.35 981.39
CELF2 -0.0005267 9668 GTEx DepMap Descartes 0.81 52.17
PLEKHA2 -0.0005290 9688 GTEx DepMap Descartes 0.58 42.36
SCML4 -0.0006367 10664 GTEx DepMap Descartes 0.00 0.00
NCALD -0.0006454 10738 GTEx DepMap Descartes 0.00 0.00
PITPNC1 -0.0006901 11029 GTEx DepMap Descartes 0.23 24.60
TOX -0.0007754 11474 GTEx DepMap Descartes 0.00 0.00
FOXP1 -0.0007765 11479 GTEx DepMap Descartes 1.00 43.38
ARHGAP15 -0.0008367 11719 GTEx DepMap Descartes 0.07 8.17
STK39 -0.0008624 11811 GTEx DepMap Descartes 0.01 3.10
LEF1 -0.0009201 11944 GTEx DepMap Descartes 0.01 0.43
GNG2 -0.0009213 11947 GTEx DepMap Descartes 0.54 44.60
ABLIM1 -0.0009250 11956 GTEx DepMap Descartes 0.05 6.94
CCL5 -0.0009297 11969 GTEx DepMap Descartes 0.19 86.85


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.16e-05
Mean rank of genes in gene set: 55.2
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TYROBP 0.0088685 21 GTEx DepMap Descartes 7.01 5803.14
FTH1 0.0079082 30 GTEx DepMap Descartes 46.99 19482.72
ACTB 0.0074942 33 GTEx DepMap Descartes 22.72 5151.21
SRGN 0.0054526 80 GTEx DepMap Descartes 25.96 12314.30
S100A6 0.0045470 112 GTEx DepMap Descartes 3.19 3660.67


Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.50e-03
Mean rank of genes in gene set: 66.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TYROBP 0.0088685 21 GTEx DepMap Descartes 7.01 5803.14
NEAT1 0.0066856 54 GTEx DepMap Descartes 34.54 1129.58
SAT1 0.0043597 124 GTEx DepMap Descartes 14.15 6586.30


DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.30e-02
Mean rank of genes in gene set: 2683.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CST3 0.0025752 284 GTEx DepMap Descartes 7.81 986.39
AGRP -0.0000978 3883 GTEx DepMap Descartes 0.00 0.00
MMP9 -0.0000979 3884 GTEx DepMap Descartes 0.60 68.14