Program: 25. Cancer Associated Fibroblast: Intermediate [Myo:Inf].

Program: 25. Cancer Associated Fibroblast: Intermediate [Myo:Inf].



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 COX4I2 0.0147104 cytochrome c oxidase subunit 4I2 GTEx DepMap Descartes 2.26 927.70
2 THY1 0.0146440 Thy-1 cell surface antigen GTEx DepMap Descartes 13.79 742.36
3 HIGD1B 0.0136130 HIG1 hypoxia inducible domain family member 1B GTEx DepMap Descartes 3.75 1610.68
4 PDGFRB 0.0134208 platelet derived growth factor receptor beta GTEx DepMap Descartes 4.42 217.91
5 NOTCH3 0.0132354 notch receptor 3 GTEx DepMap Descartes 3.41 110.86
6 UACA 0.0130159 uveal autoantigen with coiled-coil domains and ankyrin repeats GTEx DepMap Descartes 5.52 192.40
7 TDO2 0.0125950 tryptophan 2,3-dioxygenase GTEx DepMap Descartes 0.92 59.42
8 ABCC9 0.0125613 ATP binding cassette subfamily C member 9 GTEx DepMap Descartes 0.87 28.68
9 BGN 0.0123491 biglycan GTEx DepMap Descartes 8.73 927.61
10 EDNRA 0.0115854 endothelin receptor type A GTEx DepMap Descartes 1.01 68.00
11 PRRX1 0.0110480 paired related homeobox 1 GTEx DepMap Descartes 1.59 103.43
12 NR2F2 0.0103802 nuclear receptor subfamily 2 group F member 2 GTEx DepMap Descartes 5.29 260.73
13 CALD1 0.0103556 caldesmon 1 GTEx DepMap Descartes 18.61 904.51
14 TINAGL1 0.0101246 tubulointerstitial nephritis antigen like 1 GTEx DepMap Descartes 2.62 151.45
15 PLXDC1 0.0099939 plexin domain containing 1 GTEx DepMap Descartes 1.94 77.85
16 MCAM 0.0099203 melanoma cell adhesion molecule GTEx DepMap Descartes 4.70 231.86
17 IGFBP7 0.0096524 insulin like growth factor binding protein 7 GTEx DepMap Descartes 103.55 18269.22
18 COL4A2 0.0095712 collagen type IV alpha 2 chain GTEx DepMap Descartes 11.87 405.34
19 RRAS 0.0088673 RAS related GTEx DepMap Descartes 2.65 683.93
20 CSPG4 0.0088577 chondroitin sulfate proteoglycan 4 GTEx DepMap Descartes 0.83 23.04
21 RASL12 0.0088023 RAS like family 12 GTEx DepMap Descartes 0.48 44.79
22 ANO1 0.0087127 anoctamin 1 GTEx DepMap Descartes 0.61 34.04
23 ENPEP 0.0085302 glutamyl aminopeptidase GTEx DepMap Descartes 0.73 26.67
24 KCNJ8 0.0084889 potassium inwardly rectifying channel subfamily J member 8 GTEx DepMap Descartes 1.19 133.66
25 PDE1A 0.0084705 phosphodiesterase 1A GTEx DepMap Descartes 0.55 29.62
26 FILIP1L 0.0082999 filamin A interacting protein 1 like GTEx DepMap Descartes 2.76 165.16
27 COL4A1 0.0081674 collagen type IV alpha 1 chain GTEx DepMap Descartes 11.15 355.87
28 EPS8 0.0081558 epidermal growth factor receptor pathway substrate 8 GTEx DepMap Descartes 2.20 112.02
29 NDUFA4L2 0.0081134 NDUFA4 mitochondrial complex associated like 2 GTEx DepMap Descartes 12.29 2637.34
30 COL18A1 0.0079902 collagen type XVIII alpha 1 chain GTEx DepMap Descartes 5.23 196.09
31 MYLK 0.0079320 myosin light chain kinase GTEx DepMap Descartes 2.72 62.55
32 ARHGAP42 0.0078839 Rho GTPase activating protein 42 GTEx DepMap Descartes 0.68 23.53
33 OLFML2A 0.0078782 olfactomedin like 2A GTEx DepMap Descartes 1.35 54.44
34 PDGFA 0.0077919 platelet derived growth factor subunit A GTEx DepMap Descartes 1.65 178.71
35 EHD2 0.0075984 EH domain containing 2 GTEx DepMap Descartes 1.08 77.07
36 EVA1B 0.0075854 eva-1 homolog B GTEx DepMap Descartes 2.46 NA
37 TPM2 0.0075721 tropomyosin 2 GTEx DepMap Descartes 12.38 1920.98
38 SPARCL1 0.0075613 SPARC like 1 GTEx DepMap Descartes 10.26 877.47
39 GPRC5C 0.0072363 G protein-coupled receptor class C group 5 member C GTEx DepMap Descartes 0.80 84.24
40 CD248 0.0071984 CD248 molecule GTEx DepMap Descartes 1.13 113.36
41 CD36 0.0071958 CD36 molecule GTEx DepMap Descartes 2.95 117.56
42 ITGA1 0.0071668 integrin subunit alpha 1 GTEx DepMap Descartes 3.01 69.14
43 STEAP4 0.0071268 STEAP4 metalloreductase GTEx DepMap Descartes 0.92 26.53
44 REM1 0.0070027 RRAD and GEM like GTPase 1 GTEx DepMap Descartes 0.43 65.45
45 MFGE8 0.0068689 milk fat globule EGF and factor V/VIII domain containing GTEx DepMap Descartes 3.13 341.13
46 COL6A2 0.0068538 collagen type VI alpha 2 chain GTEx DepMap Descartes 7.32 535.99
47 SOD3 0.0067720 superoxide dismutase 3 GTEx DepMap Descartes 2.92 615.00
48 COL5A2 0.0067385 collagen type V alpha 2 chain GTEx DepMap Descartes 2.29 75.12
49 TRPC6 0.0067112 transient receptor potential cation channel subfamily C member 6 GTEx DepMap Descartes 0.22 10.17
50 SPARC 0.0066699 secreted protein acidic and cysteine rich GTEx DepMap Descartes 19.87 1288.70


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UMAP plots showing activity of gene expression program identified in GEP 25. Cancer Associated Fibroblast: Intermediate [Myo:Inf]:

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2 2.44e-46 108.89 57.10 1.64e-43 1.64e-43
35THY1, HIGD1B, PDGFRB, NOTCH3, UACA, ABCC9, BGN, EDNRA, NR2F2, CALD1, PLXDC1, MCAM, IGFBP7, COL4A2, CSPG4, RASL12, KCNJ8, COL4A1, EPS8, NDUFA4L2, COL18A1, MYLK, ARHGAP42, OLFML2A, EHD2, TPM2, SPARCL1, GPRC5C, CD248, ITGA1, MFGE8, COL6A2, COL5A2, TRPC6, SPARC
 303
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_VASCULAR_SMOOTH_MUSCLE_CELLS 1.05e-26 93.39 47.23 1.17e-24 7.01e-24
18COX4I2, HIGD1B, PDGFRB, NOTCH3, NR2F2, CALD1, TINAGL1, MCAM, IGFBP7, FILIP1L, NDUFA4L2, MYLK, TPM2, SPARCL1, STEAP4, MFGE8, SOD3, SPARC
 93
DESCARTES_MAIN_FETAL_SMOOTH_MUSCLE_CELLS 8.28e-18 106.68 45.15 3.97e-16 5.55e-15
11COX4I2, HIGD1B, PDGFRB, NOTCH3, ABCC9, CSPG4, RASL12, ANO1, KCNJ8, NDUFA4L2, MYLK
 44
RUBENSTEIN_SKELETAL_MUSCLE_PERICYTES 2.06e-30 80.38 42.57 4.62e-28 1.39e-27
22COX4I2, HIGD1B, PDGFRB, NOTCH3, ABCC9, NR2F2, CALD1, TINAGL1, MCAM, IGFBP7, COL4A2, KCNJ8, COL4A1, EPS8, NDUFA4L2, TPM2, SPARCL1, CD36, STEAP4, MFGE8, COL6A2, SPARC
 144
TRAVAGLINI_LUNG_VASCULAR_SMOOTH_MUSCLE_CELL 6.28e-20 91.07 41.81 3.83e-18 4.21e-17
13COX4I2, NOTCH3, BGN, CALD1, TINAGL1, MCAM, IGFBP7, EPS8, MYLK, PDGFA, TPM2, ITGA1, SOD3
 61
MANNO_MIDBRAIN_NEUROTYPES_HPERIC 1.38e-38 58.73 29.35 4.64e-36 9.28e-36
39COX4I2, THY1, HIGD1B, PDGFRB, NOTCH3, UACA, ABCC9, BGN, EDNRA, NR2F2, CALD1, PLXDC1, MCAM, IGFBP7, COL4A2, RRAS, CSPG4, RASL12, ENPEP, KCNJ8, FILIP1L, COL4A1, EPS8, NDUFA4L2, COL18A1, MYLK, ARHGAP42, OLFML2A, EHD2, EVA1B, TPM2, SPARCL1, GPRC5C, CD248, ITGA1, MFGE8, COL5A2, TRPC6, SPARC
 795
AIZARANI_LIVER_C33_STELLATE_CELLS_2 1.27e-20 53.38 26.71 8.49e-19 8.49e-18
16NOTCH3, UACA, BGN, NR2F2, CALD1, MCAM, IGFBP7, COL4A2, COL4A1, MYLK, TPM2, SPARCL1, ITGA1, COL6A2, SOD3, SPARC
 126
DESCARTES_FETAL_HEART_SMOOTH_MUSCLE_CELLS 6.62e-12 64.16 24.33 2.34e-10 4.44e-09
8COX4I2, HIGD1B, PDGFRB, NOTCH3, ABCC9, ENPEP, KCNJ8, NDUFA4L2
 45
FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL 5.60e-26 36.78 20.04 5.37e-24 3.76e-23
25HIGD1B, PDGFRB, NOTCH3, UACA, BGN, EDNRA, NR2F2, CALD1, PLXDC1, MCAM, IGFBP7, COL4A2, RRAS, CSPG4, KCNJ8, COL4A1, NDUFA4L2, COL18A1, EVA1B, TPM2, CD248, ITGA1, COL6A2, COL5A2, SPARC
 365
GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS 1.57e-28 36.27 19.83 2.64e-26 1.06e-25
29THY1, HIGD1B, PDGFRB, NOTCH3, BGN, EDNRA, CALD1, MCAM, IGFBP7, COL4A2, CSPG4, KCNJ8, PDE1A, FILIP1L, COL4A1, NDUFA4L2, COL18A1, OLFML2A, EHD2, EVA1B, TPM2, SPARCL1, CD36, ITGA1, STEAP4, MFGE8, COL6A2, COL5A2, SPARC
 505
TRAVAGLINI_LUNG_PERICYTE_CELL 1.43e-14 38.65 17.86 5.64e-13 9.59e-12
12COX4I2, HIGD1B, PDGFRB, NOTCH3, PLXDC1, MCAM, COL4A2, CSPG4, COL4A1, NDUFA4L2, ITGA1, TRPC6
 114
DESCARTES_FETAL_CEREBELLUM_VASCULAR_ENDOTHELIAL_CELLS 2.71e-27 31.14 17.00 3.64e-25 1.82e-24
30HIGD1B, PDGFRB, NOTCH3, UACA, ABCC9, BGN, EDNRA, CALD1, TINAGL1, PLXDC1, MCAM, IGFBP7, COL4A2, RRAS, RASL12, ENPEP, KCNJ8, COL4A1, NDUFA4L2, COL18A1, OLFML2A, EHD2, EVA1B, GPRC5C, CD248, ITGA1, REM1, COL6A2, TRPC6, SPARC
 633
DESCARTES_FETAL_MUSCLE_SMOOTH_MUSCLE_CELLS 1.66e-11 39.69 16.32 5.58e-10 1.12e-08
9COX4I2, PDGFRB, ABCC9, EDNRA, RASL12, ANO1, ENPEP, NDUFA4L2, STEAP4
 78
MENON_FETAL_KIDNEY_3_STROMAL_CELLS 2.36e-11 38.04 15.67 7.53e-10 1.58e-08
9UACA, NR2F2, CALD1, COL4A2, COL4A1, MYLK, TPM2, COL5A2, SPARC
 81
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS 2.64e-11 37.51 15.47 8.04e-10 1.77e-08
9THY1, BGN, PRRX1, NR2F2, CALD1, IGFBP7, TPM2, COL6A2, SPARC
 82
FAN_OVARY_CL14_MATURE_SMOOTH_MUSCLE_CELL 1.28e-18 26.72 14.07 7.17e-17 8.61e-16
19HIGD1B, NOTCH3, BGN, NR2F2, CALD1, TINAGL1, MCAM, IGFBP7, RASL12, EPS8, NDUFA4L2, COL18A1, MYLK, EHD2, TPM2, SPARCL1, MFGE8, SOD3, SPARC
 306
DESCARTES_FETAL_CEREBRUM_VASCULAR_ENDOTHELIAL_CELLS 1.91e-22 24.25 13.29 1.60e-20 1.28e-19
26COX4I2, HIGD1B, PDGFRB, NOTCH3, UACA, ABCC9, BGN, EDNRA, TINAGL1, PLXDC1, MCAM, IGFBP7, COL4A2, RRAS, RASL12, KCNJ8, COL4A1, COL18A1, OLFML2A, EHD2, EVA1B, GPRC5C, CD248, ITGA1, COL6A2, SPARC
 585
MURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL 3.36e-22 22.50 12.35 2.50e-20 2.25e-19
27THY1, PDGFRB, NOTCH3, UACA, BGN, EDNRA, PRRX1, NR2F2, CALD1, PLXDC1, IGFBP7, COL4A2, RASL12, ANO1, COL4A1, EPS8, COL18A1, MYLK, OLFML2A, EHD2, TPM2, CD248, ITGA1, MFGE8, COL6A2, COL5A2, SPARC
 680
HU_FETAL_RETINA_FIBROBLAST 3.81e-18 22.84 12.17 1.97e-16 2.55e-15
20THY1, PDGFRB, NOTCH3, UACA, BGN, EDNRA, PRRX1, NR2F2, CALD1, MCAM, IGFBP7, COL4A2, COL4A1, EPS8, EVA1B, TPM2, CD248, COL6A2, COL5A2, SPARC
 385
AIZARANI_LIVER_C21_STELLATE_CELLS_1 3.42e-13 24.24 11.63 1.27e-11 2.29e-10
13THY1, BGN, NR2F2, CALD1, IGFBP7, COL4A2, RRAS, FILIP1L, COL4A1, MYLK, COL6A2, SOD3, SPARC
 194

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 1.15e-11 20.99 9.83 5.75e-10 5.75e-10
12THY1, PDGFRB, BGN, PRRX1, CALD1, COL4A2, COL4A1, MYLK, TPM2, COL6A2, COL5A2, SPARC
 200
HALLMARK_MYOGENESIS 9.73e-07 12.40 4.96 2.43e-05 4.87e-05
8IGFBP7, COL4A2, MYLK, TPM2, CD36, COL6A2, SOD3, SPARC
 200
HALLMARK_ANGIOGENESIS 3.84e-04 24.16 4.58 6.40e-03 1.92e-02
3KCNJ8, PDGFA, COL5A2
 36
HALLMARK_ADIPOGENESIS 7.71e-03 5.55 1.44 9.64e-02 3.85e-01
4COL4A1, MYLK, SPARCL1, CD36
 200
HALLMARK_XENOBIOTIC_METABOLISM 4.35e-02 4.05 0.80 3.63e-01 1.00e+00
3TDO2, ENPEP, CD36
 200
HALLMARK_KRAS_SIGNALING_UP 4.35e-02 4.05 0.80 3.63e-01 1.00e+00
3PRRX1, ANO1, SPARCL1
 200
HALLMARK_UV_RESPONSE_DN 1.10e-01 3.67 0.43 6.08e-01 1.00e+00
2PDGFRB, COL5A2
 144
HALLMARK_FATTY_ACID_METABOLISM 1.28e-01 3.34 0.39 6.08e-01 1.00e+00
2TDO2, CD36
 158
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 6.08e-01 1.00e+00
2PDGFRB, BGN
 161
HALLMARK_APICAL_JUNCTION 1.85e-01 2.63 0.31 6.60e-01 1.00e+00
2THY1, RRAS
 200
HALLMARK_COMPLEMENT 1.85e-01 2.63 0.31 6.60e-01 1.00e+00
2COL4A2, CD36
 200
HALLMARK_NOTCH_SIGNALING 1.20e-01 8.23 0.20 6.08e-01 1.00e+00
1NOTCH3
 32
HALLMARK_HEDGEHOG_SIGNALING 1.34e-01 7.29 0.18 6.08e-01 1.00e+00
1THY1
 36
HALLMARK_APICAL_SURFACE 1.61e-01 5.93 0.14 6.60e-01 1.00e+00
1THY1
 44
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 9.75e-01 1.00e+00
1CD36
 87
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 1.00e+00 1.00e+00
1STEAP4
 100
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 1.00e+00 1.00e+00
1SPARC
 138
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1BGN
 200
HALLMARK_P53_PATHWAY 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1PDGFA
 200
HALLMARK_ALLOGRAFT_REJECTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1THY1
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_ECM_RECEPTOR_INTERACTION 9.07e-07 21.83 7.39 8.72e-05 1.69e-04
6COL4A2, COL4A1, CD36, ITGA1, COL6A2, COL5A2
 84
KEGG_FOCAL_ADHESION 9.38e-07 12.47 4.99 8.72e-05 1.74e-04
8PDGFRB, COL4A2, COL4A1, MYLK, PDGFA, ITGA1, COL6A2, COL5A2
 199
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 1.42e-03 6.68 2.05 8.82e-02 2.64e-01
5PDGFRB, RRAS, MYLK, PDGFA, ITGA1
 213
KEGG_CALCIUM_SIGNALING_PATHWAY 5.16e-03 6.25 1.62 2.40e-01 9.60e-01
4PDGFRB, EDNRA, PDE1A, MYLK
 178
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 1.05e-02 7.12 1.40 3.90e-01 1.00e+00
3EDNRA, CALD1, MYLK
 115
KEGG_GLIOMA 2.73e-02 8.26 0.95 6.11e-01 1.00e+00
2PDGFRB, PDGFA
 65
KEGG_PATHWAYS_IN_CANCER 3.70e-02 3.39 0.88 6.11e-01 1.00e+00
4PDGFRB, COL4A2, COL4A1, PDGFA
 325
KEGG_MELANOMA 3.21e-02 7.55 0.87 6.11e-01 1.00e+00
2PDGFRB, PDGFA
 71
KEGG_CARDIAC_MUSCLE_CONTRACTION 3.90e-02 6.76 0.78 6.11e-01 1.00e+00
2COX4I2, TPM2
 79
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 4.26e-02 6.43 0.74 6.11e-01 1.00e+00
2TPM2, ITGA1
 83
KEGG_SMALL_CELL_LUNG_CANCER 4.36e-02 6.35 0.74 6.11e-01 1.00e+00
2COL4A2, COL4A1
 84
KEGG_HEMATOPOIETIC_CELL_LINEAGE 4.64e-02 6.13 0.71 6.11e-01 1.00e+00
2CD36, ITGA1
 87
KEGG_PROSTATE_CANCER 4.83e-02 5.98 0.69 6.11e-01 1.00e+00
2PDGFRB, PDGFA
 89
KEGG_DILATED_CARDIOMYOPATHY 4.93e-02 5.92 0.69 6.11e-01 1.00e+00
2TPM2, ITGA1
 90
KEGG_GAP_JUNCTION 4.93e-02 5.92 0.69 6.11e-01 1.00e+00
2PDGFRB, PDGFA
 90
KEGG_MAPK_SIGNALING_PATHWAY 8.58e-02 3.02 0.60 8.87e-01 1.00e+00
3PDGFRB, RRAS, PDGFA
 267
KEGG_PARKINSONS_DISEASE 9.30e-02 4.07 0.47 8.87e-01 1.00e+00
2COX4I2, NDUFA4L2
 130
KEGG_OXIDATIVE_PHOSPHORYLATION 9.54e-02 4.01 0.47 8.87e-01 1.00e+00
2COX4I2, NDUFA4L2
 132
KEGG_RENIN_ANGIOTENSIN_SYSTEM 6.56e-02 15.93 0.37 7.62e-01 1.00e+00
1ENPEP
 17
KEGG_ALZHEIMERS_DISEASE 1.39e-01 3.18 0.37 1.00e+00 1.00e+00
2COX4I2, NDUFA4L2
 166

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr12p12 8.63e-03 7.67 1.50 1.00e+00 1.00e+00
3ABCC9, KCNJ8, EPS8
 107
chr11q22 5.73e-02 5.42 0.63 1.00e+00 1.00e+00
2ARHGAP42, TRPC6
 98
chr2q32 6.78e-02 4.91 0.57 1.00e+00 1.00e+00
2PDE1A, COL5A2
 108
chr7q21 1.36e-01 3.21 0.38 1.00e+00 1.00e+00
2CD36, STEAP4
 164
chr15q26 1.75e-01 2.73 0.32 1.00e+00 1.00e+00
2NR2F2, MFGE8
 193
chr11q23 1.92e-01 2.57 0.30 1.00e+00 1.00e+00
2THY1, MCAM
 205
chr20q11 2.37e-01 2.22 0.26 1.00e+00 1.00e+00
2COX4I2, REM1
 237
chr21q22 3.99e-01 1.48 0.17 1.00e+00 1.00e+00
2COL18A1, COL6A2
 353
chr11q13 6.78e-01 1.24 0.15 1.00e+00 1.00e+00
2ANO1, CD248
 421
chr3q12 1.67e-01 5.67 0.14 1.00e+00 1.00e+00
1FILIP1L
 46
chr7q33 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1CALD1
 52
chr15q23 2.28e-01 3.99 0.10 1.00e+00 1.00e+00
1UACA
 65
chr4q22 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1SPARCL1
 70
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1IGFBP7
 79
chr5q11 2.87e-01 3.04 0.07 1.00e+00 1.00e+00
1ITGA1
 85
chr4q25 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1ENPEP
 87
chr5q33 3.52e-01 2.36 0.06 1.00e+00 1.00e+00
1SPARC
 109
chr4q32 3.62e-01 2.28 0.06 1.00e+00 1.00e+00
1TDO2
 113
chr15q24 3.69e-01 2.22 0.05 1.00e+00 1.00e+00
1CSPG4
 116
chr19q13 4.39e-01 0.45 0.05 1.00e+00 1.00e+00
2RRAS, EHD2
 1165

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
SRF_C 1.48e-03 6.61 2.03 5.10e-01 1.00e+00
5NR2F2, CALD1, MCAM, MYLK, CD248
 215
SRF_Q5_01 1.80e-03 6.31 1.94 5.10e-01 1.00e+00
5NR2F2, CALD1, MYLK, TPM2, CD248
 225
CCAWWNAAGG_SRF_Q4 5.05e-03 9.38 1.83 5.95e-01 1.00e+00
3CALD1, MYLK, TPM2
 88
SRF_Q6 2.73e-03 5.72 1.76 5.10e-01 1.00e+00
5NR2F2, CALD1, MYLK, TPM2, CD248
 248
AP3_Q6 2.88e-03 5.65 1.73 5.10e-01 1.00e+00
5EDNRA, CALD1, ENPEP, MYLK, SPARC
 251
CEBP_Q3 3.07e-03 5.56 1.71 5.10e-01 1.00e+00
5PDGFRB, EDNRA, NR2F2, CALD1, NDUFA4L2
 255
WGGAATGY_TEF1_Q6 3.60e-03 4.48 1.55 5.10e-01 1.00e+00
6TINAGL1, RRAS, PDE1A, PDGFA, GPRC5C, SPARC
 387
AAANWWTGC_UNKNOWN 7.07e-03 5.69 1.47 7.04e-01 1.00e+00
4PDGFRB, NR2F2, MYLK, SPARCL1
 195
HOX13_01 1.43e-02 11.83 1.35 7.04e-01 1.00e+00
2PRRX1, CALD1
 46
PAX4_04 1.11e-02 4.96 1.29 7.04e-01 1.00e+00
4CALD1, PDE1A, MYLK, STEAP4
 223
SRF_Q4 1.23e-02 4.81 1.25 7.04e-01 1.00e+00
4NR2F2, CALD1, MYLK, TPM2
 230
SRF_01 1.74e-02 10.62 1.22 7.04e-01 1.00e+00
2CALD1, CD248
 51
ATF1_Q6 1.36e-02 4.67 1.21 7.04e-01 1.00e+00
4CALD1, MCAM, PDE1A, PDGFA
 237
MEF2_03 1.42e-02 4.61 1.19 7.04e-01 1.00e+00
4PRRX1, MYLK, TPM2, MFGE8
 240
S8_01 1.56e-02 4.47 1.16 7.04e-01 1.00e+00
4PRRX1, CALD1, GPRC5C, CD36
 247
LFA1_Q6 1.64e-02 4.40 1.14 7.04e-01 1.00e+00
4PRRX1, RASL12, NDUFA4L2, OLFML2A
 251
AP4_Q6_01 1.77e-02 4.30 1.11 7.04e-01 1.00e+00
4MCAM, RASL12, NDUFA4L2, MYLK
 257
MEIS1BHOXA9_01 1.90e-02 5.66 1.11 7.18e-01 1.00e+00
3NR2F2, TPM2, STEAP4
 144
NR2E3_TARGET_GENES 2.37e-02 50.83 1.06 7.66e-01 1.00e+00
1EPS8
 6
RORA2_01 2.34e-02 5.21 1.03 7.66e-01 1.00e+00
3COX4I2, MYLK, STEAP4
 156

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_CELL_MIGRATION_INVOLVED_IN_KIDNEY_DEVELOPMENT 1.54e-04 172.68 14.09 1.44e-01 1.00e+00
2PDGFRB, PDGFA
 5
GOBP_TONIC_SMOOTH_MUSCLE_CONTRACTION 6.85e-04 64.86 6.55 4.27e-01 1.00e+00
2EDNRA, MYLK
 10
GOBP_BLOOD_VESSEL_MORPHOGENESIS 1.80e-11 10.68 5.61 1.35e-07 1.35e-07
18THY1, PDGFRB, EDNRA, PRRX1, NR2F2, CALD1, PLXDC1, MCAM, COL4A2, RRAS, CSPG4, ENPEP, COL4A1, COL18A1, MYLK, PDGFA, MFGE8, SPARC
 677
GOBP_COLLAGEN_ACTIVATED_TYROSINE_KINASE_RECEPTOR_SIGNALING_PATHWAY 9.99e-04 51.89 5.39 5.34e-01 1.00e+00
2COL4A2, COL4A1
 12
GOBP_DERMATAN_SULFATE_METABOLIC_PROCESS 1.18e-03 47.19 4.96 5.39e-01 1.00e+00
2BGN, CSPG4
 13
GOBP_VASCULATURE_DEVELOPMENT 1.84e-10 9.16 4.82 6.88e-07 1.38e-06
18THY1, PDGFRB, EDNRA, PRRX1, NR2F2, CALD1, PLXDC1, MCAM, COL4A2, RRAS, CSPG4, ENPEP, COL4A1, COL18A1, MYLK, PDGFA, MFGE8, SPARC
 786
GOBP_CHONDROITIN_SULFATE_CATABOLIC_PROCESS 1.37e-03 43.30 4.59 5.39e-01 1.00e+00
2BGN, CSPG4
 14
GOBP_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BETA_SIGNALING_PATHWAY 1.37e-03 43.30 4.59 5.39e-01 1.00e+00
2PDGFRB, PDGFA
 14
GOBP_COLLAGEN_ACTIVATED_SIGNALING_PATHWAY 1.58e-03 39.95 4.27 5.53e-01 1.00e+00
2COL4A2, COL4A1
 15
GOBP_TUBE_MORPHOGENESIS 1.43e-09 7.98 4.20 3.57e-06 1.07e-05
18THY1, PDGFRB, EDNRA, PRRX1, NR2F2, CALD1, PLXDC1, MCAM, COL4A2, RRAS, CSPG4, ENPEP, COL4A1, COL18A1, MYLK, PDGFA, MFGE8, SPARC
 900
GOBP_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS 1.80e-03 37.11 3.99 5.85e-01 1.00e+00
2BGN, CSPG4
 16
GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT 6.66e-09 6.84 3.64 1.25e-05 4.99e-05
19THY1, PDGFRB, EDNRA, PRRX1, NR2F2, CALD1, PLXDC1, MCAM, COL4A2, RRAS, CSPG4, ENPEP, KCNJ8, COL4A1, COL18A1, MYLK, PDGFA, MFGE8, SPARC
 1140
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION 2.20e-06 8.10 3.58 2.36e-03 1.65e-02
10BGN, COL4A2, COL4A1, COL18A1, OLFML2A, PDGFA, ITGA1, COL6A2, COL5A2, SPARC
 396
GOBP_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE 2.28e-03 32.49 3.53 6.82e-01 1.00e+00
2PDGFRB, COL4A1
 18
GOBP_TUBE_DEVELOPMENT 2.21e-08 6.60 3.47 3.31e-05 1.66e-04
18THY1, PDGFRB, EDNRA, PRRX1, NR2F2, CALD1, PLXDC1, MCAM, COL4A2, RRAS, CSPG4, ENPEP, COL4A1, COL18A1, MYLK, PDGFA, MFGE8, SPARC
 1085
GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS 4.59e-08 6.26 3.30 5.72e-05 3.43e-04
18THY1, PDGFRB, EDNRA, CALD1, PLXDC1, MCAM, COL4A2, RRAS, CSPG4, ENPEP, COL4A1, COL18A1, PDGFA, EHD2, CD36, MFGE8, COL5A2, SPARC
 1142
GOBP_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION 1.26e-03 15.63 3.02 5.39e-01 1.00e+00
3THY1, RRAS, CD36
 54
GOBP_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION 3.10e-03 27.37 3.01 7.25e-01 1.00e+00
2PRRX1, PDGFA
 21
GOBP_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY 3.10e-03 27.37 3.01 7.25e-01 1.00e+00
2PDGFRB, ITGA1
 21
GOBP_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 1.48e-03 14.76 2.85 5.53e-01 1.00e+00
3PDGFRB, CSPG4, PDGFA
 57

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 1.19e-05 10.54 3.95 5.79e-02 5.79e-02
7BGN, IGFBP7, RRAS, COL4A1, OLFML2A, SPARCL1, MFGE8
 200
GSE27670_CTRL_VS_BLIMP1_TRANSDUCED_GC_BCELL_DN 1.24e-04 8.78 3.02 3.01e-01 6.03e-01
6TINAGL1, RRAS, ENPEP, EPS8, COL5A2, SPARC
 200
GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_BCELL_UP 9.88e-04 7.27 2.23 1.00e+00 1.00e+00
5HIGD1B, BGN, EDNRA, CSPG4, OLFML2A
 196
GSE1460_INTRATHYMIC_T_PROGENITOR_VS_THYMIC_STROMAL_CELL_DN 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5EDNRA, RRAS, OLFML2A, PDGFA, COL6A2
 200
GSE20715_WT_VS_TLR4_KO_LUNG_UP 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5BGN, ANO1, PDGFA, CD36, SOD3
 200
GSE3720_UNSTIM_VS_LPS_STIM_VD2_GAMMADELTA_TCELL_DN 3.03e-03 7.29 1.88 1.00e+00 1.00e+00
4KCNJ8, COL4A1, EPS8, SOD3
 153
GSE40685_NAIVE_CD4_TCELL_VS_FOXP3_KO_TREG_PRECURSOR_DN 7.07e-03 5.69 1.47 1.00e+00 1.00e+00
4COL4A2, REM1, COL6A2, SPARC
 195
GSE29618_PRE_VS_DAY7_FLU_VACCINE_BCELL_UP 7.20e-03 5.66 1.47 1.00e+00 1.00e+00
4HIGD1B, CSPG4, NDUFA4L2, OLFML2A
 196
GSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_CORD_BLOOD_DN 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4KCNJ8, EHD2, TPM2, TRPC6
 198
GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_DN 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4TDO2, MYLK, SOD3, TRPC6
 198
GSE360_LOW_DOSE_B_MALAYI_VS_M_TUBERCULOSIS_MAC_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4NOTCH3, TDO2, CD36, REM1
 199
GSE5589_WT_VS_IL6_KO_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_DN 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4COL4A2, CSPG4, COL4A1, CD36
 199
GSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_6H_IFNA_STIM_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4HIGD1B, IGFBP7, OLFML2A, ITGA1
 199
GSE1460_NAIVE_CD4_TCELL_ADULT_BLOOD_VS_THYMIC_STROMAL_CELL_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4EDNRA, OLFML2A, PDGFA, COL6A2
 200
GSE30083_SP3_VS_SP4_THYMOCYTE_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4NOTCH3, UACA, ABCC9, MCAM
 200
GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4RRAS, RASL12, KCNJ8, EVA1B
 200
GSE360_L_DONOVANI_VS_L_MAJOR_MAC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4THY1, PRRX1, ENPEP, PDE1A
 200
GSE7852_LN_VS_FAT_TCONV_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4KCNJ8, COL4A1, SPARCL1, ITGA1
 200
GSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4BGN, IGFBP7, COL4A2, TPM2
 200
GSE4748_CTRL_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4COL4A1, EHD2, CD36, COL6A2
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
NOTCH3 5 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Fragment of NOTCH. Is a coactivator.
PRRX1 11 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NR2F2 12 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
CD36 41 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ID3 69 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
TGFB1I1 74 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Available evidence suggests that it acts as a co-factor
EBF2 79 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain EBF1 has a nice HT-SELEX model and based on this paper (PMID:23499423). EBF2 binds similar motif to control brown/beige fat cell identity.
MEF2C 89 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HEYL 109 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
TBX15 119 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HEY2 123 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
AGT 162 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MSC 178 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
LPP 182 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None znfLIM is probably not a DNA binding domain (PMID: 8506279). The protein has been reported to be coactivator for ETV4 (PMID: 16738319).
EPAS1 184 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
SNAI2 192 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
GLI3 201 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RUNX1 223 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
ZFP36L1 228 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA-binding protein (PMID: 27102483; PMID: 17013884).
HOXB7 234 Yes Known motif Monomer or homomultimer High-throughput in vitro None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T230_TGTTGAGGTCTACTGA-1 Smooth_muscle_cells:vascular 0.16 1861.50
Raw ScoresMSC: 0.4, Smooth_muscle_cells:vascular: 0.4, Fibroblasts:foreskin: 0.39, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.39, Tissue_stem_cells:lipoma-derived_MSC: 0.39, Neurons:Schwann_cell: 0.39, Tissue_stem_cells:BM_MSC: 0.38, iPS_cells:skin_fibroblast: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, iPS_cells:PDB_fibroblasts: 0.38
T200_ATAGACCGTACGCTTA-1 Fibroblasts:foreskin 0.14 1724.98
Raw ScoresMSC: 0.4, Fibroblasts:foreskin: 0.4, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.39, Smooth_muscle_cells:vascular: 0.39, Neurons:Schwann_cell: 0.39, Tissue_stem_cells:lipoma-derived_MSC: 0.39, Endothelial_cells:HUVEC:PR8-infected: 0.39, iPS_cells:skin_fibroblast: 0.39, iPS_cells:fibroblasts: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39
T200_CCTATCGTCCCGAATA-1 Smooth_muscle_cells:vascular 0.16 1502.61
Raw ScoresMSC: 0.38, Smooth_muscle_cells:vascular: 0.37, Neurons:Schwann_cell: 0.37, Fibroblasts:foreskin: 0.36, iPS_cells:CRL2097_foreskin: 0.35, iPS_cells:skin_fibroblast: 0.35, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.35, iPS_cells:PDB_fibroblasts: 0.35, iPS_cells:fibroblasts: 0.35, Tissue_stem_cells:lipoma-derived_MSC: 0.35
T200_TGATGCATCGAAGGAC-1 Neurons:adrenal_medulla_cell_line 0.09 1342.05
Raw ScoresNeurons:Schwann_cell: 0.34, MSC: 0.33, Fibroblasts:foreskin: 0.32, Smooth_muscle_cells:vascular: 0.32, Tissue_stem_cells:dental_pulp: 0.32, iPS_cells:foreskin_fibrobasts: 0.31, Tissue_stem_cells:lipoma-derived_MSC: 0.31, iPS_cells:CRL2097_foreskin: 0.31, iPS_cells:adipose_stem_cells: 0.31, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.31
T214_ATTCAGGGTATTGAGA-1 Osteoblasts 0.10 1323.22
Raw ScoresOsteoblasts: 0.32, iPS_cells:adipose_stem_cells: 0.32, Tissue_stem_cells:BM_MSC:BMP2: 0.31, iPS_cells:CRL2097_foreskin: 0.31, Osteoblasts:BMP2: 0.31, Tissue_stem_cells:BM_MSC:TGFb3: 0.31, Tissue_stem_cells:iliac_MSC: 0.31, Smooth_muscle_cells:bronchial: 0.31, Fibroblasts:breast: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31
T214_GCTTTCGCATAATCCG-1 Tissue_stem_cells:BM_MSC:BMP2 0.12 1160.17
Raw ScoresiPS_cells:adipose_stem_cells: 0.38, Tissue_stem_cells:iliac_MSC: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Fibroblasts:breast: 0.37, MSC: 0.36, Fibroblasts:foreskin: 0.36, iPS_cells:CRL2097_foreskin: 0.36, Neurons:Schwann_cell: 0.36, Smooth_muscle_cells:vascular: 0.36, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.36
T200_ACAAAGAGTCCGGACT-1 Endothelial_cells:HUVEC:IFNg 0.09 1148.87
Raw ScoresFibroblasts:foreskin: 0.36, Tissue_stem_cells:iliac_MSC: 0.36, Smooth_muscle_cells:vascular: 0.36, iPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Fibroblasts:breast: 0.36, Neurons:Schwann_cell: 0.36, Osteoblasts: 0.35, MSC: 0.35
T214_TCGCACTTCCTTATCA-1 Smooth_muscle_cells:vascular 0.17 1107.74
Raw ScoresMSC: 0.39, Fibroblasts:foreskin: 0.38, Smooth_muscle_cells:vascular: 0.38, iPS_cells:CRL2097_foreskin: 0.37, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.37, Tissue_stem_cells:lipoma-derived_MSC: 0.37, iPS_cells:skin_fibroblast: 0.37, iPS_cells:foreskin_fibrobasts: 0.37, iPS_cells:fibroblasts: 0.37, Neurons:Schwann_cell: 0.37
T200_CACAGGCTCAAATGAG-1 Tissue_stem_cells:BM_MSC:BMP2 0.16 1094.42
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.39, iPS_cells:adipose_stem_cells: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Fibroblasts:breast: 0.37, Tissue_stem_cells:BM_MSC: 0.37, Osteoblasts: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, Fibroblasts:foreskin: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Smooth_muscle_cells:vascular: 0.37
T214_AGTTCGACAGAGCCCT-1 Tissue_stem_cells:BM_MSC:BMP2 0.14 1086.34
Raw ScoresiPS_cells:adipose_stem_cells: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Smooth_muscle_cells:bronchial: 0.36, Tissue_stem_cells:iliac_MSC: 0.36, Fibroblasts:breast: 0.36, Smooth_muscle_cells:bronchial:vit_D: 0.36, Osteoblasts: 0.36, iPS_cells:CRL2097_foreskin: 0.35, Smooth_muscle_cells:vascular: 0.35
T214_GTTCTATCAATAACGA-1 Tissue_stem_cells:BM_MSC:TGFb3 0.12 1029.52
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.34, Fibroblasts:breast: 0.34, iPS_cells:adipose_stem_cells: 0.34, Tissue_stem_cells:BM_MSC: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, Smooth_muscle_cells:vascular: 0.33, MSC: 0.33, iPS_cells:CRL2097_foreskin: 0.33, Fibroblasts:foreskin: 0.33, Neurons:Schwann_cell: 0.33
T214_TGATGCATCATACGAC-1 Tissue_stem_cells:BM_MSC:BMP2 0.14 999.37
Raw ScoresiPS_cells:adipose_stem_cells: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, Fibroblasts:breast: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Osteoblasts: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Smooth_muscle_cells:bronchial: 0.36, Tissue_stem_cells:BM_MSC: 0.36, Fibroblasts:foreskin: 0.35
T200_GCCAACGCATGAAGGC-1 Tissue_stem_cells:BM_MSC:BMP2 0.11 937.43
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.34, iPS_cells:adipose_stem_cells: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, Fibroblasts:foreskin: 0.33, Fibroblasts:breast: 0.33, Osteoblasts: 0.33, Smooth_muscle_cells:bronchial: 0.33, Tissue_stem_cells:iliac_MSC: 0.33, Smooth_muscle_cells:vascular: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32
T230_ACTATGGCACGGTGAA-1 iPS_cells:adipose_stem_cells 0.18 926.97
Raw ScoresiPS_cells:adipose_stem_cells: 0.42, MSC: 0.42, Tissue_stem_cells:BM_MSC: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Fibroblasts:foreskin: 0.41, Smooth_muscle_cells:vascular: 0.41, Fibroblasts:breast: 0.41, Neurons:Schwann_cell: 0.41, iPS_cells:foreskin_fibrobasts: 0.4, iPS_cells:PDB_fibroblasts: 0.4
T200_CTCCATGGTACGACAG-1 Tissue_stem_cells:BM_MSC:BMP2 0.14 924.48
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.38, iPS_cells:adipose_stem_cells: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, Osteoblasts: 0.36, Fibroblasts:breast: 0.36, Osteoblasts:BMP2: 0.35, Tissue_stem_cells:BM_MSC: 0.35, Smooth_muscle_cells:bronchial: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Chondrocytes:MSC-derived: 0.35
T214_TTGTGTTAGAGTCGAC-1 Tissue_stem_cells:BM_MSC:BMP2 0.12 881.24
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.34, iPS_cells:adipose_stem_cells: 0.34, Tissue_stem_cells:iliac_MSC: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Osteoblasts: 0.34, Tissue_stem_cells:BM_MSC: 0.34, Fibroblasts:breast: 0.34, Smooth_muscle_cells:vascular: 0.33, Tissue_stem_cells:BM_MSC:osteogenic: 0.33, Chondrocytes:MSC-derived: 0.33
T200_AATAGAGGTGCTTCAA-1 Tissue_stem_cells:BM_MSC:BMP2 0.11 817.57
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.37, iPS_cells:adipose_stem_cells: 0.37, Smooth_muscle_cells:vascular: 0.36, Smooth_muscle_cells:bronchial: 0.36, Fibroblasts:foreskin: 0.36, Tissue_stem_cells:iliac_MSC: 0.36, iPS_cells:CRL2097_foreskin: 0.36, Neurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial:vit_D: 0.36, Fibroblasts:breast: 0.36
T200_TCTACATTCCAGCTCT-1 Smooth_muscle_cells:vascular 0.14 817.22
Raw ScoresFibroblasts:foreskin: 0.38, Fibroblasts:breast: 0.38, iPS_cells:adipose_stem_cells: 0.38, iPS_cells:CRL2097_foreskin: 0.38, MSC: 0.38, Smooth_muscle_cells:vascular: 0.37, iPS_cells:foreskin_fibrobasts: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Neurons:Schwann_cell: 0.37, Tissue_stem_cells:BM_MSC: 0.36
T214_CCTTGTGAGGGTCACA-1 Tissue_stem_cells:iliac_MSC 0.11 791.44
Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Tissue_stem_cells:BM_MSC: 0.33, Fibroblasts:breast: 0.33, Smooth_muscle_cells:bronchial: 0.33, Osteoblasts: 0.33, Tissue_stem_cells:iliac_MSC: 0.33, Smooth_muscle_cells:vascular: 0.33, Neurons:Schwann_cell: 0.33
T200_GACTTCCTCCCTCTCC-1 Tissue_stem_cells:BM_MSC:BMP2 0.16 789.33
Raw ScoresOsteoblasts: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, iPS_cells:adipose_stem_cells: 0.36, Smooth_muscle_cells:bronchial: 0.36, Fibroblasts:breast: 0.36, Tissue_stem_cells:iliac_MSC: 0.36, Tissue_stem_cells:BM_MSC: 0.36, iPS_cells:CRL2097_foreskin: 0.36, Smooth_muscle_cells:bronchial:vit_D: 0.35
T200_GTTTGGAAGTTGAAGT-1 Tissue_stem_cells:BM_MSC:BMP2 0.14 784.56
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.36, iPS_cells:adipose_stem_cells: 0.36, Fibroblasts:foreskin: 0.36, Fibroblasts:breast: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Tissue_stem_cells:iliac_MSC: 0.35, Osteoblasts: 0.35, iPS_cells:CRL2097_foreskin: 0.35, Smooth_muscle_cells:bronchial: 0.35, Tissue_stem_cells:BM_MSC: 0.35
T214_GTTGTGACATTGTGCA-1 iPS_cells:adipose_stem_cells 0.15 784.35
Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.35, Osteoblasts: 0.34, Tissue_stem_cells:BM_MSC: 0.34, Fibroblasts:breast: 0.34, iPS_cells:CRL2097_foreskin: 0.34, Chondrocytes:MSC-derived: 0.34, Smooth_muscle_cells:bronchial: 0.34, Smooth_muscle_cells:vascular: 0.34
T214_ACTATGGAGACTAAGT-1 iPS_cells:adipose_stem_cells 0.15 769.89
Raw ScoresiPS_cells:adipose_stem_cells: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Tissue_stem_cells:BM_MSC: 0.37, Osteoblasts: 0.37, Fibroblasts:breast: 0.37, Smooth_muscle_cells:bronchial: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, MSC: 0.37
T214_GGAGGTATCGTAACTG-1 Tissue_stem_cells:BM_MSC:BMP2 0.12 769.86
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.32, iPS_cells:adipose_stem_cells: 0.32, Fibroblasts:breast: 0.31, Tissue_stem_cells:iliac_MSC: 0.31, Smooth_muscle_cells:bronchial: 0.31, iPS_cells:CRL2097_foreskin: 0.31, Tissue_stem_cells:BM_MSC:TGFb3: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, Fibroblasts:foreskin: 0.31, Osteoblasts: 0.3
T214_GTGGAGAGTCGATGCC-1 Tissue_stem_cells:BM_MSC:TGFb3 0.12 754.26
Raw ScoresSmooth_muscle_cells:bronchial: 0.33, Smooth_muscle_cells:bronchial:vit_D: 0.33, iPS_cells:adipose_stem_cells: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Fibroblasts:breast: 0.32, Smooth_muscle_cells:vascular: 0.32, Tissue_stem_cells:iliac_MSC: 0.32, Osteoblasts: 0.32, iPS_cells:CRL2097_foreskin: 0.32
T200_GTCAAACGTCCAGCCA-1 Endothelial_cells:HUVEC:IFNg 0.10 747.69
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.37, Endothelial_cells:lymphatic: 0.37, Endothelial_cells:HUVEC:IFNg: 0.37, Endothelial_cells:blood_vessel: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:lymphatic:KSHV: 0.35, Endothelial_cells:HUVEC:B._anthracis_LT: 0.35, Endothelial_cells:HUVEC:H5N1-infected: 0.35, Endothelial_cells:HUVEC: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35
T214_TCCTAATTCACCTCGT-1 Osteoblasts 0.14 745.61
Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Fibroblasts:breast: 0.35, iPS_cells:CRL2097_foreskin: 0.34, Smooth_muscle_cells:bronchial:vit_D: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Smooth_muscle_cells:bronchial: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Smooth_muscle_cells:vascular: 0.34, Tissue_stem_cells:BM_MSC: 0.33, Osteoblasts: 0.33
T214_GAATCGTGTTGTCCCT-1 Smooth_muscle_cells:vascular 0.12 745.51
Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Smooth_muscle_cells:vascular: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Fibroblasts:breast: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Osteoblasts: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC: 0.34, Smooth_muscle_cells:bronchial: 0.34, iPS_cells:CRL2097_foreskin: 0.34
T200_GTTACCCCATAACCCA-1 Fibroblasts:foreskin 0.13 729.18
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.38, iPS_cells:adipose_stem_cells: 0.38, Fibroblasts:foreskin: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Smooth_muscle_cells:bronchial: 0.37, Smooth_muscle_cells:vascular: 0.37, Fibroblasts:breast: 0.37, Smooth_muscle_cells:bronchial:vit_D: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, Tissue_stem_cells:BM_MSC: 0.37
T200_TAATTCCGTTCTCGCT-1 Tissue_stem_cells:BM_MSC:BMP2 0.15 726.31
Raw ScoresiPS_cells:adipose_stem_cells: 0.37, Osteoblasts: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Fibroblasts:breast: 0.37, Tissue_stem_cells:BM_MSC: 0.37, iPS_cells:CRL2097_foreskin: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Fibroblasts:foreskin: 0.36, Smooth_muscle_cells:vascular: 0.36, Tissue_stem_cells:iliac_MSC: 0.36
T214_TGCTCGTAGATGAACT-1 Tissue_stem_cells:BM_MSC:BMP2 0.11 726.29
Raw ScoresFibroblasts:foreskin: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, iPS_cells:CRL2097_foreskin: 0.34, iPS_cells:adipose_stem_cells: 0.34, iPS_cells:foreskin_fibrobasts: 0.34, MSC: 0.34, Tissue_stem_cells:BM_MSC: 0.33, Smooth_muscle_cells:vascular: 0.33, Tissue_stem_cells:iliac_MSC: 0.33, Osteoblasts: 0.33
T214_ACGATGTGTACCGTGC-1 Neurons:Schwann_cell 0.08 724.59
Raw ScoresiPS_cells:adipose_stem_cells: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.33, Tissue_stem_cells:BM_MSC: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, Osteoblasts: 0.32, Tissue_stem_cells:iliac_MSC: 0.32, Fibroblasts:breast: 0.32, Fibroblasts:foreskin: 0.32, Tissue_stem_cells:BM_MSC:osteogenic: 0.32, Smooth_muscle_cells:vascular: 0.32
T214_AGCCAATAGATCCCAT-1 Tissue_stem_cells:BM_MSC:TGFb3 0.11 711.30
Raw ScoresiPS_cells:adipose_stem_cells: 0.34, Smooth_muscle_cells:bronchial: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, iPS_cells:CRL2097_foreskin: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Smooth_muscle_cells:bronchial:vit_D: 0.34, Tissue_stem_cells:iliac_MSC: 0.34, Tissue_stem_cells:BM_MSC: 0.33, Fibroblasts:breast: 0.33, Osteoblasts: 0.33
T200_CTGGCAGTCAGCTGTA-1 Tissue_stem_cells:BM_MSC:BMP2 0.13 708.73
Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Fibroblasts:breast: 0.35, Osteoblasts: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Fibroblasts:foreskin: 0.34, iPS_cells:CRL2097_foreskin: 0.34, Smooth_muscle_cells:bronchial: 0.34, Smooth_muscle_cells:vascular: 0.34, Tissue_stem_cells:BM_MSC: 0.34
T200_GAACGTTTCATAGGCT-1 Tissue_stem_cells:BM_MSC:BMP2 0.12 707.55
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.39, iPS_cells:adipose_stem_cells: 0.38, Tissue_stem_cells:iliac_MSC: 0.38, Fibroblasts:foreskin: 0.38, Fibroblasts:breast: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, Smooth_muscle_cells:vascular: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Tissue_stem_cells:BM_MSC: 0.37, Osteoblasts: 0.37
T200_ACTTATCGTCCTCCAT-1 Tissue_stem_cells:BM_MSC:BMP2 0.13 705.47
Raw ScoresSmooth_muscle_cells:vascular: 0.39, iPS_cells:adipose_stem_cells: 0.39, MSC: 0.39, Fibroblasts:foreskin: 0.38, Fibroblasts:breast: 0.38, iPS_cells:CRL2097_foreskin: 0.38, iPS_cells:foreskin_fibrobasts: 0.38, iPS_cells:skin_fibroblast: 0.38, iPS_cells:PDB_fibroblasts: 0.38, Neurons:Schwann_cell: 0.37
T200_AAGTTCGGTCCTCCTA-1 Tissue_stem_cells:BM_MSC:BMP2 0.15 691.73
Raw ScoresiPS_cells:adipose_stem_cells: 0.38, Fibroblasts:breast: 0.38, Osteoblasts: 0.38, Tissue_stem_cells:BM_MSC: 0.38, Smooth_muscle_cells:vascular: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, MSC: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.37
T200_GGTGATTCACAACCGC-1 Fibroblasts:foreskin 0.13 689.38
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.35, Fibroblasts:foreskin: 0.35, iPS_cells:adipose_stem_cells: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC: 0.34, Osteoblasts: 0.33, Tissue_stem_cells:iliac_MSC: 0.33, Smooth_muscle_cells:vascular: 0.33, Smooth_muscle_cells:bronchial: 0.33, Fibroblasts:breast: 0.33
T200_TAGAGTCCACATATGC-1 Smooth_muscle_cells:vascular 0.15 681.62
Raw ScoresSmooth_muscle_cells:vascular: 0.32, MSC: 0.32, Fibroblasts:foreskin: 0.32, Tissue_stem_cells:BM_MSC: 0.31, Fibroblasts:breast: 0.31, Neurons:Schwann_cell: 0.31, iPS_cells:CRL2097_foreskin: 0.31, iPS_cells:foreskin_fibrobasts: 0.31, Osteoblasts: 0.31, iPS_cells:adipose_stem_cells: 0.3
T200_ATCGTCCGTACCCGAC-1 Smooth_muscle_cells:bronchial 0.15 678.96
Raw ScoresSmooth_muscle_cells:bronchial: 0.35, Smooth_muscle_cells:bronchial:vit_D: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Osteoblasts: 0.34, iPS_cells:CRL2097_foreskin: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, iPS_cells:adipose_stem_cells: 0.34, Fibroblasts:breast: 0.34, Tissue_stem_cells:iliac_MSC: 0.33, Chondrocytes:MSC-derived: 0.33
T200_CGGAATTAGGATACGC-1 Tissue_stem_cells:BM_MSC:BMP2 0.12 669.93
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.33, Smooth_muscle_cells:bronchial: 0.33, Fibroblasts:breast: 0.33, iPS_cells:adipose_stem_cells: 0.33, Smooth_muscle_cells:bronchial:vit_D: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, iPS_cells:CRL2097_foreskin: 0.32, Fibroblasts:foreskin: 0.32, Osteoblasts: 0.32, Tissue_stem_cells:iliac_MSC: 0.32
T200_ACTGTCCTCTCGGCTT-1 Tissue_stem_cells:BM_MSC:BMP2 0.12 664.71
Raw ScoresFibroblasts:foreskin: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Osteoblasts: 0.35, iPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.35, Fibroblasts:breast: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Tissue_stem_cells:BM_MSC: 0.35, iPS_cells:CRL2097_foreskin: 0.34, Smooth_muscle_cells:vascular: 0.34
T200_GCACGTGCAGAGAGGG-1 Tissue_stem_cells:BM_MSC:BMP2 0.13 658.37
Raw ScoresSmooth_muscle_cells:bronchial: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Smooth_muscle_cells:bronchial:vit_D: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Fibroblasts:foreskin: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, iPS_cells:adipose_stem_cells: 0.34, Fibroblasts:breast: 0.34, Osteoblasts: 0.34, iPS_cells:CRL2097_foreskin: 0.34
T200_TACTTCATCGGTCATA-1 Tissue_stem_cells:BM_MSC:BMP2 0.14 631.16
Raw ScoresiPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Fibroblasts:breast: 0.36, iPS_cells:CRL2097_foreskin: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Smooth_muscle_cells:vascular: 0.35, Fibroblasts:foreskin: 0.35, Smooth_muscle_cells:bronchial: 0.35, Osteoblasts: 0.35, MSC: 0.35
T200_CGTGATACAAACCATC-1 Tissue_stem_cells:BM_MSC 0.12 624.79
Raw ScoresFibroblasts:foreskin: 0.36, iPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC: 0.36, Smooth_muscle_cells:vascular: 0.36, Fibroblasts:breast: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Osteoblasts: 0.35, MSC: 0.35, Neurons:Schwann_cell: 0.35
T200_CTCCAACTCGTTCCCA-1 Fibroblasts:foreskin 0.14 620.22
Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.38, Osteoblasts: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, Fibroblasts:foreskin: 0.37, Fibroblasts:breast: 0.37, iPS_cells:adipose_stem_cells: 0.37, Smooth_muscle_cells:bronchial: 0.37, Tissue_stem_cells:BM_MSC: 0.37, Chondrocytes:MSC-derived: 0.37
T214_GGGATCCGTAGACGGT-1 Neurons:adrenal_medulla_cell_line 0.10 615.08
Raw ScoresMSC: 0.32, Smooth_muscle_cells:vascular: 0.31, Fibroblasts:foreskin: 0.31, Tissue_stem_cells:lipoma-derived_MSC: 0.31, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.31, Fibroblasts:breast: 0.31, Neurons:Schwann_cell: 0.31, iPS_cells:CRL2097_foreskin: 0.31, iPS_cells:fibroblasts: 0.31, iPS_cells:skin_fibroblast: 0.31
T200_CAGCCAGTCACAATGC-1 Tissue_stem_cells:BM_MSC:BMP2 0.15 612.01
Raw ScoresiPS_cells:adipose_stem_cells: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Fibroblasts:breast: 0.37, Osteoblasts: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, Tissue_stem_cells:BM_MSC: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Smooth_muscle_cells:vascular: 0.37, Smooth_muscle_cells:bronchial: 0.36, Tissue_stem_cells:iliac_MSC: 0.36
T214_CTCACTGGTCTAGGTT-1 Fibroblasts:breast 0.14 598.07
Raw ScoresiPS_cells:adipose_stem_cells: 0.35, Osteoblasts: 0.35, iPS_cells:CRL2097_foreskin: 0.34, Fibroblasts:breast: 0.34, Smooth_muscle_cells:bronchial: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Smooth_muscle_cells:bronchial:vit_D: 0.34, Tissue_stem_cells:iliac_MSC: 0.34, Tissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC: 0.34
T214_AGGGCTCAGCAATAAC-1 Smooth_muscle_cells:vascular 0.12 595.53
Raw ScoresiPS_cells:adipose_stem_cells: 0.32, Tissue_stem_cells:iliac_MSC: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Osteoblasts: 0.31, Fibroblasts:breast: 0.31, Smooth_muscle_cells:bronchial: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, iPS_cells:CRL2097_foreskin: 0.31, Smooth_muscle_cells:vascular: 0.31


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.08e-09
Mean rank of genes in gene set: 3357.29
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
THY1 0.0146440 2 GTEx DepMap Descartes 13.79 742.36
BGN 0.0123491 9 GTEx DepMap Descartes 8.73 927.61
IGFBP7 0.0096524 17 GTEx DepMap Descartes 103.55 18269.22
COL4A1 0.0081674 27 GTEx DepMap Descartes 11.15 355.87
MYLK 0.0079320 31 GTEx DepMap Descartes 2.72 62.55
TPM2 0.0075721 37 GTEx DepMap Descartes 12.38 1920.98
COL5A2 0.0067385 48 GTEx DepMap Descartes 2.29 75.12
MYL9 0.0064715 52 GTEx DepMap Descartes 10.56 972.47
PGF 0.0062857 55 GTEx DepMap Descartes 2.43 181.05
MEF2C 0.0049908 89 GTEx DepMap Descartes 2.39 83.10
TPM1 0.0049695 90 GTEx DepMap Descartes 11.17 675.25
COL1A2 0.0047484 94 GTEx DepMap Descartes 13.52 548.51
TAGLN 0.0047201 95 GTEx DepMap Descartes 25.55 1662.64
ACTA2 0.0046909 99 GTEx DepMap Descartes 19.00 3282.71
COL3A1 0.0042771 117 GTEx DepMap Descartes 8.30 396.73
MMP11 0.0032938 165 GTEx DepMap Descartes 0.83 60.12
ITGA7 0.0032501 170 GTEx DepMap Descartes 0.38 22.48
RGS5 0.0031504 175 GTEx DepMap Descartes 15.45 719.24
FN1 0.0030971 180 GTEx DepMap Descartes 11.77 287.80
TNC 0.0022269 272 GTEx DepMap Descartes 1.14 25.70
COL1A1 0.0022105 277 GTEx DepMap Descartes 15.29 592.79
COL12A1 0.0017774 361 GTEx DepMap Descartes 0.59 9.19
CNN3 0.0015478 422 GTEx DepMap Descartes 3.00 324.42
MYH11 0.0012020 551 GTEx DepMap Descartes 0.79 31.75
COL14A1 0.0011530 563 GTEx DepMap Descartes 0.54 17.45
COL5A1 0.0011137 578 GTEx DepMap Descartes 0.87 19.02
HOPX 0.0006093 984 GTEx DepMap Descartes 0.71 56.27
TMEM119 0.0005954 1006 GTEx DepMap Descartes 0.17 17.23
TGFB1 0.0005940 1008 GTEx DepMap Descartes 0.96 70.11
POSTN 0.0004185 1330 GTEx DepMap Descartes 3.43 198.36
CNN2 0.0003857 1400 GTEx DepMap Descartes 0.51 48.95
COL13A1 0.0003830 1408 GTEx DepMap Descartes 0.03 2.43
TGFBR2 0.0003217 1634 GTEx DepMap Descartes 0.83 29.89
IGFBP3 0.0002008 2211 GTEx DepMap Descartes 0.70 31.14
COL8A1 -0.0000121 5258 GTEx DepMap Descartes 0.47 15.31
COL10A1 -0.0000175 5418 GTEx DepMap Descartes 0.00 0.00
TGFB2 -0.0000774 7363 GTEx DepMap Descartes 0.09 2.51
VEGFA -0.0000952 7935 GTEx DepMap Descartes 0.17 2.66
WNT5A -0.0001100 8397 GTEx DepMap Descartes 0.03 0.54
VCAN -0.0001224 8758 GTEx DepMap Descartes 1.27 18.14
TGFBR1 -0.0001839 10170 GTEx DepMap Descartes 0.22 5.59
LUM -0.0002489 11147 GTEx DepMap Descartes 2.37 237.67
COL11A1 -0.0002506 11161 GTEx DepMap Descartes 0.02 0.20
MMP2 -0.0003338 11840 GTEx DepMap Descartes 0.63 31.29
DCN -0.0003785 12024 GTEx DepMap Descartes 2.23 73.35
THBS2 -0.0004143 12149 GTEx DepMap Descartes 0.49 20.13
COL15A1 -0.0004495 12248 GTEx DepMap Descartes 1.00 24.94
THBS1 -0.0008999 12533 GTEx DepMap Descartes 0.88 17.20
ACTG2 -0.0018245 12549 GTEx DepMap Descartes 0.92 86.84


Mesenchymal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.38e-04
Mean rank of genes in gene set: 118.75
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL6A1 0.0058418 65 GTEx DepMap Descartes 4.76 264.36
COL1A2 0.0047484 94 GTEx DepMap Descartes 13.52 548.51
COL3A1 0.0042771 117 GTEx DepMap Descartes 8.30 396.73
VIM 0.0027993 199 GTEx DepMap Descartes 38.66 3064.49


Stroma (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Stroma cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.40e-04
Mean rank of genes in gene set: 771.2
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL6A1 0.0058418 65 GTEx DepMap Descartes 4.76 264.36
COL3A1 0.0042771 117 GTEx DepMap Descartes 8.30 396.73
FN1 0.0030971 180 GTEx DepMap Descartes 11.77 287.80
COL5A1 0.0011137 578 GTEx DepMap Descartes 0.87 19.02
GPC3 0.0001221 2916 GTEx DepMap Descartes 0.28 22.15




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10648.68
Median rank of genes in gene set: 11712
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RGS5 0.0031504 175 GTEx DepMap Descartes 15.45 719.24
CYGB 0.0023880 243 GTEx DepMap Descartes 1.63 194.99
SYNPO2 0.0010389 616 GTEx DepMap Descartes 0.88 12.59
SLIT3 0.0008385 741 GTEx DepMap Descartes 1.48 41.03
GNB1 0.0002800 1802 GTEx DepMap Descartes 1.35 84.83
ARHGEF7 0.0002434 1969 GTEx DepMap Descartes 0.46 15.78
NFIL3 0.0002159 2118 GTEx DepMap Descartes 0.27 30.50
NET1 0.0002119 2148 GTEx DepMap Descartes 0.35 20.26
EML4 0.0001909 2268 GTEx DepMap Descartes 0.46 20.84
ANP32A 0.0001678 2481 GTEx DepMap Descartes 1.21 58.98
CETN3 0.0001278 2859 GTEx DepMap Descartes 0.25 23.74
AKAP12 0.0001059 3085 GTEx DepMap Descartes 1.86 40.85
KLF13 0.0000882 3314 GTEx DepMap Descartes 0.41 12.38
KLHL23 0.0000858 3343 GTEx DepMap Descartes 1.05 44.88
TUBB4B 0.0000740 3515 GTEx DepMap Descartes 2.51 214.23
SETD7 0.0000655 3626 GTEx DepMap Descartes 0.21 4.90
HEY1 0.0000491 3909 GTEx DepMap Descartes 0.15 6.85
FBXO8 0.0000418 4016 GTEx DepMap Descartes 0.40 35.10
FAM167A 0.0000396 4053 GTEx DepMap Descartes 0.01 0.51
FKBP4 0.0000226 4379 GTEx DepMap Descartes 1.03 59.53
TMEM108 0.0000155 4527 GTEx DepMap Descartes 0.14 3.77
AHSA1 0.0000025 4829 GTEx DepMap Descartes 0.86 129.44
RET -0.0000013 4924 GTEx DepMap Descartes 0.02 0.88
CD200 -0.0000053 5037 GTEx DepMap Descartes 0.46 41.89
MSH6 -0.0000082 5116 GTEx DepMap Descartes 0.43 10.84
EXOC5 -0.0000160 5376 GTEx DepMap Descartes 0.29 5.32
PHPT1 -0.0000170 5397 GTEx DepMap Descartes 3.28 487.76
MAGI3 -0.0000230 5644 GTEx DepMap Descartes 0.15 3.09
RAB6B -0.0000242 5683 GTEx DepMap Descartes 0.28 9.85
SHC3 -0.0000511 6527 GTEx DepMap Descartes 0.01 0.66


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.62e-85
Mean rank of genes in gene set: 2948.77
Median rank of genes in gene set: 1230
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BGN 0.0123491 9 GTEx DepMap Descartes 8.73 927.61
EDNRA 0.0115854 10 GTEx DepMap Descartes 1.01 68.00
PRRX1 0.0110480 11 GTEx DepMap Descartes 1.59 103.43
CALD1 0.0103556 13 GTEx DepMap Descartes 18.61 904.51
COL4A2 0.0095712 18 GTEx DepMap Descartes 11.87 405.34
FILIP1L 0.0082999 26 GTEx DepMap Descartes 2.76 165.16
COL4A1 0.0081674 27 GTEx DepMap Descartes 11.15 355.87
EPS8 0.0081558 28 GTEx DepMap Descartes 2.20 112.02
OLFML2A 0.0078782 33 GTEx DepMap Descartes 1.35 54.44
EHD2 0.0075984 35 GTEx DepMap Descartes 1.08 77.07
TPM2 0.0075721 37 GTEx DepMap Descartes 12.38 1920.98
SPARCL1 0.0075613 38 GTEx DepMap Descartes 10.26 877.47
COL6A2 0.0068538 46 GTEx DepMap Descartes 7.32 535.99
COL5A2 0.0067385 48 GTEx DepMap Descartes 2.29 75.12
SPARC 0.0066699 50 GTEx DepMap Descartes 19.87 1288.70
IFITM3 0.0062687 56 GTEx DepMap Descartes 27.51 10279.85
SYDE1 0.0061214 60 GTEx DepMap Descartes 0.44 26.39
COL6A1 0.0058418 65 GTEx DepMap Descartes 4.76 264.36
ITGB1 0.0057107 67 GTEx DepMap Descartes 8.91 559.81
ID3 0.0056153 69 GTEx DepMap Descartes 9.41 2653.03
PLS3 0.0054992 71 GTEx DepMap Descartes 1.10 81.51
TGFB1I1 0.0053590 74 GTEx DepMap Descartes 2.38 121.32
TNS1 0.0053075 76 GTEx DepMap Descartes 0.87 19.20
PEAK1 0.0051454 83 GTEx DepMap Descartes 0.89 NA
TIMP1 0.0050978 84 GTEx DepMap Descartes 39.35 7448.88
KANK2 0.0050055 86 GTEx DepMap Descartes 0.76 37.89
S1PR3 0.0049977 87 GTEx DepMap Descartes 0.56 18.02
TPM1 0.0049695 90 GTEx DepMap Descartes 11.17 675.25
A2M 0.0047065 96 GTEx DepMap Descartes 5.05 251.09
OLFML2B 0.0047064 97 GTEx DepMap Descartes 1.72 149.03


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 8171.86
Median rank of genes in gene set: 9020
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PAPSS2 0.0006825 903 GTEx DepMap Descartes 0.23 11.77
FDX1 0.0002931 1740 GTEx DepMap Descartes 0.67 44.50
SH3PXD2B 0.0002558 1916 GTEx DepMap Descartes 0.17 3.58
POR 0.0002099 2152 GTEx DepMap Descartes 0.41 34.74
NPC1 0.0000774 3464 GTEx DepMap Descartes 0.05 2.53
GRAMD1B 0.0000431 3994 GTEx DepMap Descartes 0.06 1.08
IGF1R 0.0000276 4276 GTEx DepMap Descartes 0.27 4.00
SCAP 0.0000185 4463 GTEx DepMap Descartes 0.22 8.63
PDE10A -0.0000074 5092 GTEx DepMap Descartes 0.11 2.16
INHA -0.0000624 6885 GTEx DepMap Descartes 0.00 0.00
STAR -0.0000656 6995 GTEx DepMap Descartes 0.01 0.22
FDXR -0.0000730 7225 GTEx DepMap Descartes 0.13 11.20
LDLR -0.0000750 7288 GTEx DepMap Descartes 0.16 5.77
ERN1 -0.0000885 7711 GTEx DepMap Descartes 0.08 1.97
FREM2 -0.0000908 7785 GTEx DepMap Descartes 0.01 0.05
BAIAP2L1 -0.0001000 8081 GTEx DepMap Descartes 0.01 0.54
SGCZ -0.0001279 8916 GTEx DepMap Descartes 0.01 0.10
DHCR24 -0.0001292 8938 GTEx DepMap Descartes 0.05 1.54
CYB5B -0.0001360 9102 GTEx DepMap Descartes 0.38 16.97
FDPS -0.0001403 9205 GTEx DepMap Descartes 1.14 98.99
SLC16A9 -0.0001575 9583 GTEx DepMap Descartes 0.02 0.41
FRMD5 -0.0001583 9600 GTEx DepMap Descartes 0.02 0.38
MSMO1 -0.0001840 10171 GTEx DepMap Descartes 0.17 12.86
SCARB1 -0.0002015 10506 GTEx DepMap Descartes 0.10 2.85
HMGCR -0.0002114 10655 GTEx DepMap Descartes 0.09 3.12
HMGCS1 -0.0002252 10841 GTEx DepMap Descartes 0.20 6.16
GSTA4 -0.0002324 10950 GTEx DepMap Descartes 0.69 76.40
DNER -0.0002434 11079 GTEx DepMap Descartes 0.08 2.65
SLC1A2 -0.0002601 11272 GTEx DepMap Descartes 0.04 0.27
APOC1 -0.0002794 11471 GTEx DepMap Descartes 1.77 361.73


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11045.05
Median rank of genes in gene set: 11868
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SYNPO2 0.0010389 616 GTEx DepMap Descartes 0.88 12.59
FAT3 -0.0000251 5715 GTEx DepMap Descartes 0.09 1.00
EPHA6 -0.0001183 8647 GTEx DepMap Descartes 0.01 0.22
ANKFN1 -0.0001231 8775 GTEx DepMap Descartes 0.00 0.00
RPH3A -0.0001273 8898 GTEx DepMap Descartes 0.03 0.54
RYR2 -0.0001373 9138 GTEx DepMap Descartes 0.09 0.87
SLC44A5 -0.0001381 9159 GTEx DepMap Descartes 0.02 0.46
ALK -0.0001612 9668 GTEx DepMap Descartes 0.02 0.79
PTCHD1 -0.0001905 10300 GTEx DepMap Descartes 0.04 0.39
HS3ST5 -0.0001971 10429 GTEx DepMap Descartes 0.00 0.09
EYA4 -0.0002182 10747 GTEx DepMap Descartes 0.01 0.25
PLXNA4 -0.0002270 10868 GTEx DepMap Descartes 0.03 0.26
TMEM132C -0.0002346 10969 GTEx DepMap Descartes 0.02 0.65
KCNB2 -0.0002349 10975 GTEx DepMap Descartes 0.03 0.98
CNKSR2 -0.0002464 11107 GTEx DepMap Descartes 0.04 0.50
SLC6A2 -0.0002508 11165 GTEx DepMap Descartes 0.03 0.73
EYA1 -0.0002527 11188 GTEx DepMap Descartes 0.06 1.19
TMEFF2 -0.0002964 11594 GTEx DepMap Descartes 0.12 3.48
RBFOX1 -0.0002980 11600 GTEx DepMap Descartes 0.03 0.96
IL7 -0.0003293 11809 GTEx DepMap Descartes 0.12 6.76
NTRK1 -0.0003393 11868 GTEx DepMap Descartes 0.10 3.24
RGMB -0.0003636 11966 GTEx DepMap Descartes 0.17 3.98
REEP1 -0.0003810 12035 GTEx DepMap Descartes 0.18 5.72
GAL -0.0003935 12078 GTEx DepMap Descartes 0.29 60.76
GREM1 -0.0004763 12292 GTEx DepMap Descartes 0.01 0.07
CNTFR -0.0005129 12358 GTEx DepMap Descartes 0.15 6.92
MARCH11 -0.0005158 12362 GTEx DepMap Descartes 0.82 NA
MAB21L2 -0.0005217 12369 GTEx DepMap Descartes 0.48 16.81
ELAVL2 -0.0005449 12387 GTEx DepMap Descartes 0.38 9.59
CCND1 -0.0005506 12393 GTEx DepMap Descartes 3.34 134.92


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9864.53
Median rank of genes in gene set: 11243.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ARHGAP29 0.0025321 232 GTEx DepMap Descartes 1.54 39.30
EHD3 0.0006043 995 GTEx DepMap Descartes 0.08 3.78
CALCRL 0.0004124 1343 GTEx DepMap Descartes 0.34 9.82
CYP26B1 0.0000894 3287 GTEx DepMap Descartes 0.20 6.44
F8 0.0000240 4346 GTEx DepMap Descartes 0.06 1.29
MMRN2 -0.0000469 6410 GTEx DepMap Descartes 0.32 13.73
NR5A2 -0.0000787 7400 GTEx DepMap Descartes 0.03 0.93
IRX3 -0.0000948 7919 GTEx DepMap Descartes 0.07 3.25
CDH13 -0.0001070 8299 GTEx DepMap Descartes 0.28 6.52
ESM1 -0.0001366 9124 GTEx DepMap Descartes 0.50 24.16
CRHBP -0.0001588 9620 GTEx DepMap Descartes 0.00 0.00
HYAL2 -0.0001712 9898 GTEx DepMap Descartes 0.75 31.48
KANK3 -0.0001879 10259 GTEx DepMap Descartes 0.13 7.58
CEACAM1 -0.0001906 10302 GTEx DepMap Descartes 0.07 3.17
RASIP1 -0.0001963 10415 GTEx DepMap Descartes 0.18 7.52
MYRIP -0.0002180 10743 GTEx DepMap Descartes 0.02 0.37
SHANK3 -0.0002249 10838 GTEx DepMap Descartes 0.09 1.25
CHRM3 -0.0002371 10997 GTEx DepMap Descartes 0.13 1.21
ID1 -0.0002407 11045 GTEx DepMap Descartes 1.20 196.42
NOTCH4 -0.0002771 11442 GTEx DepMap Descartes 0.31 6.02
BTNL9 -0.0002893 11538 GTEx DepMap Descartes 0.04 1.27
NPR1 -0.0002913 11552 GTEx DepMap Descartes 0.02 0.79
EFNB2 -0.0003406 11876 GTEx DepMap Descartes 0.37 9.01
FLT4 -0.0003612 11960 GTEx DepMap Descartes 0.08 1.91
SHE -0.0003772 12021 GTEx DepMap Descartes 0.09 1.56
TEK -0.0004236 12176 GTEx DepMap Descartes 0.08 2.18
GALNT15 -0.0004286 12189 GTEx DepMap Descartes 0.02 NA
KDR -0.0004749 12287 GTEx DepMap Descartes 0.28 5.63
ROBO4 -0.0004756 12290 GTEx DepMap Descartes 0.29 8.38
CLDN5 -0.0004962 12330 GTEx DepMap Descartes 0.79 42.64


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.64e-04
Mean rank of genes in gene set: 4432.93
Median rank of genes in gene set: 1380.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ABCC9 0.0125613 8 GTEx DepMap Descartes 0.87 28.68
EDNRA 0.0115854 10 GTEx DepMap Descartes 1.01 68.00
PRRX1 0.0110480 11 GTEx DepMap Descartes 1.59 103.43
CD248 0.0071984 40 GTEx DepMap Descartes 1.13 113.36
COL1A2 0.0047484 94 GTEx DepMap Descartes 13.52 548.51
ACTA2 0.0046909 99 GTEx DepMap Descartes 19.00 3282.71
COL3A1 0.0042771 117 GTEx DepMap Descartes 8.30 396.73
COL6A3 0.0037783 142 GTEx DepMap Descartes 2.14 45.92
MGP 0.0036359 149 GTEx DepMap Descartes 15.41 2620.98
PCDH18 0.0034607 155 GTEx DepMap Descartes 0.29 13.68
COL1A1 0.0022105 277 GTEx DepMap Descartes 15.29 592.79
CDH11 0.0020815 306 GTEx DepMap Descartes 0.90 30.97
ADAMTSL3 0.0020797 307 GTEx DepMap Descartes 0.08 2.54
LAMC3 0.0018723 338 GTEx DepMap Descartes 0.03 0.69
PCOLCE 0.0017803 360 GTEx DepMap Descartes 2.87 465.31
COL12A1 0.0017774 361 GTEx DepMap Descartes 0.59 9.19
ITGA11 0.0016407 402 GTEx DepMap Descartes 0.13 3.06
ADAMTS2 0.0012390 530 GTEx DepMap Descartes 0.34 10.92
LRRC17 0.0011395 565 GTEx DepMap Descartes 0.14 19.66
PAMR1 0.0008185 768 GTEx DepMap Descartes 0.12 9.81
COL27A1 0.0008058 786 GTEx DepMap Descartes 0.12 3.35
POSTN 0.0004185 1330 GTEx DepMap Descartes 3.43 198.36
GLI2 0.0003750 1431 GTEx DepMap Descartes 0.04 1.04
BICC1 0.0003476 1537 GTEx DepMap Descartes 0.16 7.42
IGFBP3 0.0002008 2211 GTEx DepMap Descartes 0.70 31.14
ELN 0.0001827 2347 GTEx DepMap Descartes 0.45 25.67
DKK2 -0.0000368 6065 GTEx DepMap Descartes 0.02 1.27
C7 -0.0000499 6499 GTEx DepMap Descartes 0.18 8.03
GAS2 -0.0000878 7681 GTEx DepMap Descartes 0.02 1.18
CLDN11 -0.0001390 9177 GTEx DepMap Descartes 0.02 0.89


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9128.11
Median rank of genes in gene set: 8943.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LAMA3 0.0006253 960 GTEx DepMap Descartes 0.03 0.65
ROBO1 0.0003525 1522 GTEx DepMap Descartes 0.36 10.09
SLC35F3 -0.0000550 6624 GTEx DepMap Descartes 0.01 0.78
CNTN3 -0.0000591 6761 GTEx DepMap Descartes 0.00 0.09
SLC24A2 -0.0000593 6763 GTEx DepMap Descartes 0.00 0.00
GRM7 -0.0000722 7204 GTEx DepMap Descartes 0.00 0.00
PENK -0.0000783 7391 GTEx DepMap Descartes 0.01 2.34
GALNTL6 -0.0000854 7615 GTEx DepMap Descartes 0.01 0.45
TBX20 -0.0000872 7667 GTEx DepMap Descartes 0.00 0.00
CDH18 -0.0000883 7703 GTEx DepMap Descartes 0.00 0.13
SORCS3 -0.0000883 7704 GTEx DepMap Descartes 0.01 0.20
ST18 -0.0000951 7934 GTEx DepMap Descartes 0.00 0.00
EML6 -0.0001054 8249 GTEx DepMap Descartes 0.01 0.18
AGBL4 -0.0001067 8287 GTEx DepMap Descartes 0.03 0.76
TENM1 -0.0001082 8337 GTEx DepMap Descartes 0.02 NA
PCSK2 -0.0001132 8496 GTEx DepMap Descartes 0.01 0.35
DGKK -0.0001153 8558 GTEx DepMap Descartes 0.00 0.00
HTATSF1 -0.0001166 8600 GTEx DepMap Descartes 0.49 29.60
CCSER1 -0.0001294 8942 GTEx DepMap Descartes 0.02 NA
PACRG -0.0001295 8945 GTEx DepMap Descartes 0.02 2.93
CDH12 -0.0001316 8994 GTEx DepMap Descartes 0.00 0.00
SLC18A1 -0.0001489 9409 GTEx DepMap Descartes 0.02 0.88
FGF14 -0.0001602 9643 GTEx DepMap Descartes 0.02 0.29
KSR2 -0.0001912 10319 GTEx DepMap Descartes 0.02 0.15
SPOCK3 -0.0002078 10602 GTEx DepMap Descartes 0.02 1.19
GRID2 -0.0002549 11212 GTEx DepMap Descartes 0.04 0.70
FAM155A -0.0002611 11279 GTEx DepMap Descartes 0.13 1.59
NTNG1 -0.0002613 11281 GTEx DepMap Descartes 0.14 2.71
UNC80 -0.0002792 11466 GTEx DepMap Descartes 0.08 0.63
TIAM1 -0.0002902 11545 GTEx DepMap Descartes 0.08 1.59


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.15e-01
Mean rank of genes in gene set: 6130.31
Median rank of genes in gene set: 6364
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SELENBP1 0.0042494 120 GTEx DepMap Descartes 0.43 47.21
SPECC1 0.0017223 374 GTEx DepMap Descartes 0.38 11.38
CAT 0.0007706 816 GTEx DepMap Descartes 0.52 53.53
RAPGEF2 0.0005527 1073 GTEx DepMap Descartes 0.42 9.35
MICAL2 0.0005082 1149 GTEx DepMap Descartes 0.24 8.29
TRAK2 0.0004171 1335 GTEx DepMap Descartes 0.20 6.29
GYPC 0.0003815 1412 GTEx DepMap Descartes 1.46 165.55
RGS6 0.0001380 2758 GTEx DepMap Descartes 0.02 1.45
BLVRB 0.0001345 2791 GTEx DepMap Descartes 0.77 111.98
RHD -0.0000181 5455 GTEx DepMap Descartes 0.00 0.00
SLC25A37 -0.0000209 5568 GTEx DepMap Descartes 0.39 15.70
SLC25A21 -0.0000232 5648 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000420 6257 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0000446 6339 GTEx DepMap Descartes 0.00 0.00
CPOX -0.0000454 6364 GTEx DepMap Descartes 0.08 4.49
XPO7 -0.0000477 6434 GTEx DepMap Descartes 0.13 4.13
TFR2 -0.0000568 6682 GTEx DepMap Descartes 0.06 2.06
GCLC -0.0000696 7117 GTEx DepMap Descartes 0.10 6.86
SPTB -0.0000878 7682 GTEx DepMap Descartes 0.02 0.27
ABCB10 -0.0000971 7995 GTEx DepMap Descartes 0.01 0.75
TMCC2 -0.0001288 8930 GTEx DepMap Descartes 0.03 1.22
FECH -0.0001385 9169 GTEx DepMap Descartes 0.08 1.67
DENND4A -0.0001716 9906 GTEx DepMap Descartes 0.13 2.74
SOX6 -0.0001857 10213 GTEx DepMap Descartes 0.02 0.32
MARCH3 -0.0001908 10306 GTEx DepMap Descartes 0.07 NA
ANK1 -0.0002214 10785 GTEx DepMap Descartes 0.02 0.23
TSPAN5 -0.0002650 11324 GTEx DepMap Descartes 0.45 20.26
SNCA -0.0003406 11875 GTEx DepMap Descartes 0.16 5.82
EPB41 -0.0003465 11902 GTEx DepMap Descartes 0.10 2.27
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 7612.08
Median rank of genes in gene set: 9632.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
AXL 0.0026067 218 GTEx DepMap Descartes 0.91 47.05
ADAP2 0.0016002 412 GTEx DepMap Descartes 0.58 46.16
TGFBI 0.0010617 604 GTEx DepMap Descartes 1.71 88.33
CST3 0.0010559 609 GTEx DepMap Descartes 12.09 845.64
ITPR2 0.0006586 926 GTEx DepMap Descartes 0.34 4.95
PTPRE 0.0005436 1085 GTEx DepMap Descartes 0.58 19.28
CTSC 0.0002363 2008 GTEx DepMap Descartes 1.56 51.24
IFNGR1 0.0002094 2153 GTEx DepMap Descartes 0.48 41.47
RGL1 0.0002059 2170 GTEx DepMap Descartes 0.19 7.91
RBPJ 0.0001346 2787 GTEx DepMap Descartes 0.89 29.69
SLC9A9 0.0000889 3292 GTEx DepMap Descartes 0.11 5.90
CD163L1 -0.0000601 6797 GTEx DepMap Descartes 0.16 8.12
LGMN -0.0000831 7555 GTEx DepMap Descartes 1.13 79.94
SPP1 -0.0001042 8205 GTEx DepMap Descartes 0.37 50.39
HRH1 -0.0001136 8509 GTEx DepMap Descartes 0.06 1.50
ATP8B4 -0.0001252 8845 GTEx DepMap Descartes 0.02 0.64
SFMBT2 -0.0001255 8852 GTEx DepMap Descartes 0.02 0.20
FGD2 -0.0001295 8946 GTEx DepMap Descartes 0.02 0.62
CTSB -0.0001584 9606 GTEx DepMap Descartes 1.59 75.70
CPVL -0.0001608 9659 GTEx DepMap Descartes 0.16 11.39
WWP1 -0.0001659 9785 GTEx DepMap Descartes 0.20 7.51
CSF1R -0.0001752 9979 GTEx DepMap Descartes 0.17 5.91
HCK -0.0001829 10155 GTEx DepMap Descartes 0.11 5.66
MERTK -0.0001958 10406 GTEx DepMap Descartes 0.07 2.04
CTSD -0.0002001 10479 GTEx DepMap Descartes 1.60 147.20
MSR1 -0.0002021 10514 GTEx DepMap Descartes 0.10 2.98
SLC1A3 -0.0002054 10564 GTEx DepMap Descartes 0.05 1.60
SLCO2B1 -0.0002055 10566 GTEx DepMap Descartes 0.12 3.71
MS4A4A -0.0002255 10844 GTEx DepMap Descartes 0.24 15.36
CTSS -0.0002298 10907 GTEx DepMap Descartes 0.58 25.13


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-02
Mean rank of genes in gene set: 5567.93
Median rank of genes in gene set: 5545.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL18A1 0.0079902 30 GTEx DepMap Descartes 5.23 196.09
OLFML2A 0.0078782 33 GTEx DepMap Descartes 1.35 54.44
COL5A2 0.0067385 48 GTEx DepMap Descartes 2.29 75.12
LAMA4 0.0048177 93 GTEx DepMap Descartes 2.20 70.94
LAMC1 0.0041591 124 GTEx DepMap Descartes 1.40 40.72
VIM 0.0027993 199 GTEx DepMap Descartes 38.66 3064.49
STARD13 0.0022100 279 GTEx DepMap Descartes 0.38 13.23
LAMB1 0.0017069 382 GTEx DepMap Descartes 1.07 39.83
EDNRB 0.0014677 442 GTEx DepMap Descartes 0.40 18.70
EGFLAM 0.0012524 523 GTEx DepMap Descartes 0.29 15.54
PLCE1 0.0010341 618 GTEx DepMap Descartes 0.32 6.10
PTN 0.0006112 981 GTEx DepMap Descartes 1.14 157.41
PAG1 0.0003022 1713 GTEx DepMap Descartes 0.33 6.35
NRXN3 0.0002336 2017 GTEx DepMap Descartes 0.06 1.68
GRIK3 0.0001555 2579 GTEx DepMap Descartes 0.04 0.82
IL1RAPL1 0.0001489 2644 GTEx DepMap Descartes 0.01 0.84
SOX5 0.0001411 2718 GTEx DepMap Descartes 0.20 5.21
PMP22 0.0001012 3143 GTEx DepMap Descartes 1.52 191.15
DST 0.0000895 3286 GTEx DepMap Descartes 2.03 17.40
SLC35F1 0.0000621 3675 GTEx DepMap Descartes 0.10 3.75
PTPRZ1 -0.0000123 5268 GTEx DepMap Descartes 0.05 0.75
MPZ -0.0000199 5521 GTEx DepMap Descartes 0.10 12.91
COL25A1 -0.0000210 5570 GTEx DepMap Descartes 0.02 0.60
MDGA2 -0.0000280 5799 GTEx DepMap Descartes 0.00 0.00
XKR4 -0.0000359 6040 GTEx DepMap Descartes 0.03 0.27
TRPM3 -0.0000440 6323 GTEx DepMap Descartes 0.00 0.02
IL1RAPL2 -0.0000671 7045 GTEx DepMap Descartes 0.00 0.00
ERBB3 -0.0000736 7242 GTEx DepMap Descartes 0.14 3.19
ERBB4 -0.0000791 7415 GTEx DepMap Descartes 0.00 0.02
LRRTM4 -0.0001070 8301 GTEx DepMap Descartes 0.01 0.30


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.37e-03
Mean rank of genes in gene set: 4814.38
Median rank of genes in gene set: 2185
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MYLK 0.0079320 31 GTEx DepMap Descartes 2.72 62.55
TRPC6 0.0067112 49 GTEx DepMap Descartes 0.22 10.17
MYH9 0.0052703 78 GTEx DepMap Descartes 3.41 114.48
TLN1 0.0044101 111 GTEx DepMap Descartes 2.57 66.24
ANGPT1 0.0041980 121 GTEx DepMap Descartes 0.41 24.38
VCL 0.0038550 140 GTEx DepMap Descartes 1.53 42.48
TPM4 0.0036455 148 GTEx DepMap Descartes 6.80 292.62
INPP4B 0.0032696 169 GTEx DepMap Descartes 0.71 21.65
STOM 0.0030211 186 GTEx DepMap Descartes 1.95 144.24
FLNA 0.0022252 273 GTEx DepMap Descartes 3.08 83.00
LIMS1 0.0021922 281 GTEx DepMap Descartes 2.58 117.04
ACTN1 0.0020159 312 GTEx DepMap Descartes 2.26 102.27
ARHGAP6 0.0019608 323 GTEx DepMap Descartes 0.21 9.02
LTBP1 0.0017664 365 GTEx DepMap Descartes 0.63 23.20
RAP1B 0.0015168 431 GTEx DepMap Descartes 2.02 34.82
ITGB3 0.0014612 444 GTEx DepMap Descartes 0.01 0.31
PDE3A 0.0014385 448 GTEx DepMap Descartes 0.31 9.81
GP1BA 0.0012695 513 GTEx DepMap Descartes 0.11 9.63
GSN 0.0007123 874 GTEx DepMap Descartes 4.17 159.31
TGFB1 0.0005940 1008 GTEx DepMap Descartes 0.96 70.11
ZYX 0.0003867 1396 GTEx DepMap Descartes 0.82 75.24
SLC2A3 0.0003440 1550 GTEx DepMap Descartes 1.17 51.00
TMSB4X 0.0002041 2185 GTEx DepMap Descartes 79.59 9675.23
ACTB 0.0000247 4332 GTEx DepMap Descartes 34.03 3117.53
TUBB1 -0.0000413 6236 GTEx DepMap Descartes 0.00 0.81
SLC24A3 -0.0000549 6621 GTEx DepMap Descartes 0.01 0.35
UBASH3B -0.0000747 7272 GTEx DepMap Descartes 0.04 0.96
P2RX1 -0.0000818 7507 GTEx DepMap Descartes 0.01 0.32
HIPK2 -0.0000876 7679 GTEx DepMap Descartes 0.43 5.14
ITGA2B -0.0001061 8269 GTEx DepMap Descartes 0.00 0.09


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 7230.98
Median rank of genes in gene set: 9383
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0023363 248 GTEx DepMap Descartes 108.80 11029.31
SP100 0.0016531 398 GTEx DepMap Descartes 1.20 52.01
ARID5B 0.0012940 502 GTEx DepMap Descartes 1.49 48.93
ARHGAP15 0.0012578 518 GTEx DepMap Descartes 0.72 57.72
ARHGDIB 0.0011942 554 GTEx DepMap Descartes 3.59 741.28
ETS1 0.0011132 579 GTEx DepMap Descartes 1.01 42.23
MSN 0.0009141 694 GTEx DepMap Descartes 1.61 83.01
RCSD1 0.0007793 806 GTEx DepMap Descartes 0.43 21.83
DOCK10 0.0007254 863 GTEx DepMap Descartes 0.37 11.27
PLEKHA2 0.0004962 1170 GTEx DepMap Descartes 0.20 8.15
MBNL1 0.0003573 1498 GTEx DepMap Descartes 0.84 29.82
ITPKB 0.0002421 1974 GTEx DepMap Descartes 0.12 4.48
LEF1 0.0000418 4018 GTEx DepMap Descartes 0.25 11.69
FOXP1 0.0000284 4256 GTEx DepMap Descartes 1.12 26.70
NCALD 0.0000107 4629 GTEx DepMap Descartes 0.15 9.29
CD44 0.0000023 4836 GTEx DepMap Descartes 1.02 42.25
ANKRD44 -0.0000345 5991 GTEx DepMap Descartes 0.16 4.11
WIPF1 -0.0000811 7488 GTEx DepMap Descartes 0.33 13.09
BCL2 -0.0001098 8394 GTEx DepMap Descartes 0.26 8.31
MCTP2 -0.0001219 8741 GTEx DepMap Descartes 0.03 0.64
SAMD3 -0.0001258 8863 GTEx DepMap Descartes 0.03 1.31
CCL5 -0.0001714 9903 GTEx DepMap Descartes 0.19 24.98
CCND3 -0.0001733 9948 GTEx DepMap Descartes 0.38 28.45
SCML4 -0.0001877 10252 GTEx DepMap Descartes 0.01 0.17
IKZF1 -0.0001997 10474 GTEx DepMap Descartes 0.06 1.40
SKAP1 -0.0002021 10516 GTEx DepMap Descartes 0.03 3.36
PRKCH -0.0002045 10553 GTEx DepMap Descartes 0.12 4.08
PITPNC1 -0.0002140 10692 GTEx DepMap Descartes 0.24 6.19
STK39 -0.0002257 10851 GTEx DepMap Descartes 0.22 11.03
PDE3B -0.0002391 11025 GTEx DepMap Descartes 0.01 0.17


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.73e-03
Mean rank of genes in gene set: 2921.22
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRRX1 0.0110480 11 GTEx DepMap Descartes 1.59 103.43
SMOC2 0.0055699 70 GTEx DepMap Descartes 1.30 118.94
EBF2 0.0052508 79 GTEx DepMap Descartes 0.46 24.23
OLFML1 0.0049107 91 GTEx DepMap Descartes 0.28 29.04
F10 0.0010118 630 GTEx DepMap Descartes 0.07 13.84
ANGPTL1 0.0005002 1164 GTEx DepMap Descartes 0.05 4.66
NTRK2 0.0003427 1555 GTEx DepMap Descartes 0.38 13.11
PDGFRA -0.0001925 10341 GTEx DepMap Descartes 0.13 4.53
SFRP1 -0.0005065 12350 GTEx DepMap Descartes 0.27 7.25


pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.32e-02
Mean rank of genes in gene set: 1171.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IRF7 0.0006598 923 GTEx DepMap Descartes 0.86 106.22
CCDC50 0.0003793 1420 GTEx DepMap Descartes 0.90 19.16


B cells: Transitional B cells (curated markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.83e-02
Mean rank of genes in gene set: 255
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MYO1C 0.0022965 255 GTEx DepMap Descartes 1.06 50.49