Program: 9. Endothelial.

Program: 9. Endothelial.

Program description and justification of annotation: 9.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 FLT1 0.0209947 fms related receptor tyrosine kinase 1 GTEx DepMap Descartes 2.24 411.49
2 MECOM 0.0201301 MDS1 and EVI1 complex locus GTEx DepMap Descartes 1.55 435.78
3 DLL4 0.0163106 delta like canonical Notch ligand 4 GTEx DepMap Descartes 0.44 181.61
4 LDB2 0.0137007 LIM domain binding 2 GTEx DepMap Descartes 3.89 2591.53
5 EGFL7 0.0126636 EGF like domain multiple 7 GTEx DepMap Descartes 1.82 2292.23
6 PREX2 0.0122734 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 GTEx DepMap Descartes 0.65 96.26
7 MEF2C 0.0110825 myocyte enhancer factor 2C GTEx DepMap Descartes 1.67 369.79
8 ANO2 0.0109792 anoctamin 2 GTEx DepMap Descartes 1.02 477.30
9 ARL15 0.0108636 ADP ribosylation factor like GTPase 15 GTEx DepMap Descartes 3.85 1790.56
10 WWTR1 0.0104003 WW domain containing transcription regulator 1 GTEx DepMap Descartes 1.91 657.44
11 CALCRL 0.0103714 calcitonin receptor like receptor GTEx DepMap Descartes 1.17 398.05
12 EMCN 0.0101001 endomucin GTEx DepMap Descartes 0.80 414.91
13 ADAMTS9 0.0096713 ADAM metallopeptidase with thrombospondin type 1 motif 9 GTEx DepMap Descartes 1.99 527.02
14 HSPG2 0.0094267 heparan sulfate proteoglycan 2 GTEx DepMap Descartes 1.88 247.53
15 STC1 0.0093369 stanniocalcin 1 GTEx DepMap Descartes 0.56 176.37
16 VWF 0.0091431 von Willebrand factor GTEx DepMap Descartes 1.16 223.41
17 INSR 0.0090478 insulin receptor GTEx DepMap Descartes 3.91 652.27
18 ESM1 0.0086103 endothelial cell specific molecule 1 GTEx DepMap Descartes 0.16 65.80
19 MCTP1 0.0082794 multiple C2 and transmembrane domain containing 1 GTEx DepMap Descartes 1.53 540.46
20 EMP1 0.0081823 epithelial membrane protein 1 GTEx DepMap Descartes 1.27 576.00
21 MYCT1 0.0077569 MYC target 1 GTEx DepMap Descartes 0.09 41.00
22 VEGFC 0.0074992 vascular endothelial growth factor C GTEx DepMap Descartes 0.32 162.75
23 HES1 0.0074138 hes family bHLH transcription factor 1 GTEx DepMap Descartes 0.35 572.55
24 RHOJ 0.0073426 ras homolog family member J GTEx DepMap Descartes 0.63 362.46
25 NOTCH4 0.0073226 notch receptor 4 GTEx DepMap Descartes 0.56 132.54
26 TM4SF1 0.0073164 transmembrane 4 L six family member 1 GTEx DepMap Descartes 0.37 273.32
27 PLVAP 0.0072142 plasmalemma vesicle associated protein GTEx DepMap Descartes 0.55 375.10
28 PALMD 0.0071881 palmdelphin GTEx DepMap Descartes 0.42 180.73
29 PLEKHG1 0.0070006 pleckstrin homology and RhoGEF domain containing G1 GTEx DepMap Descartes 1.15 259.77
30 MAST4 0.0069893 microtubule associated serine/threonine kinase family member 4 GTEx DepMap Descartes 1.14 194.70
31 DYSF 0.0068530 dysferlin GTEx DepMap Descartes 0.52 156.35
32 CRIM1 0.0068001 cysteine rich transmembrane BMP regulator 1 GTEx DepMap Descartes 0.78 213.00
33 COL4A1 0.0066876 collagen type IV alpha 1 chain GTEx DepMap Descartes 1.75 503.70
34 ERG 0.0064813 ETS transcription factor ERG GTEx DepMap Descartes 0.94 NA
35 IGFBP7 0.0064530 insulin like growth factor binding protein 7 GTEx DepMap Descartes 3.34 4086.05
36 GRB10 0.0061558 growth factor receptor bound protein 10 GTEx DepMap Descartes 1.10 401.29
37 SAT1 0.0061303 spermidine/spermine N1-acetyltransferase 1 GTEx DepMap Descartes 2.17 2691.48
38 ID1 0.0059744 inhibitor of DNA binding 1, HLH protein GTEx DepMap Descartes 0.46 835.54
39 TGFBR2 0.0059431 transforming growth factor beta receptor 2 GTEx DepMap Descartes 0.74 205.94
40 COL4A2 0.0058635 collagen type IV alpha 2 chain GTEx DepMap Descartes 1.62 447.64
41 CDH5 0.0058189 cadherin 5 GTEx DepMap Descartes 0.28 129.83
42 KDR 0.0058169 kinase insert domain receptor GTEx DepMap Descartes 0.25 75.48
43 FLI1 0.0057673 Fli-1 proto-oncogene, ETS transcription factor GTEx DepMap Descartes 0.80 268.87
44 PDE4D 0.0057213 phosphodiesterase 4D GTEx DepMap Descartes 2.55 541.33
45 PTPRE 0.0056420 protein tyrosine phosphatase receptor type E GTEx DepMap Descartes 1.10 409.02
46 RASGRP3 0.0055844 RAS guanyl releasing protein 3 GTEx DepMap Descartes 0.52 216.52
47 PTPRG 0.0055071 protein tyrosine phosphatase receptor type G GTEx DepMap Descartes 2.52 458.56
48 BTNL9 0.0054856 butyrophilin like 9 GTEx DepMap Descartes 0.10 38.47
49 ADCY4 0.0054516 adenylate cyclase 4 GTEx DepMap Descartes 0.33 166.98
50 CYYR1 0.0054287 cysteine and tyrosine rich 1 GTEx DepMap Descartes 0.55 290.01


Dowload full table

UMAP plots showing activity of gene expression program identified in community:9. Endothelial

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
AIZARANI_LIVER_C10_MVECS_1 4.10e-44 103.07 54.73 2.75e-41 2.75e-41
33FLT1, LDB2, EGFL7, ARL15, WWTR1, CALCRL, EMCN, ADAMTS9, VWF, INSR, EMP1, MYCT1, HES1, RHOJ, NOTCH4, TM4SF1, PLVAP, PALMD, MAST4, DYSF, CRIM1, COL4A1, ERG, IGFBP7, GRB10, ID1, TGFBR2, CDH5, KDR, PTPRG, BTNL9, ADCY4, CYYR1
 269
DESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS 1.96e-29 82.14 43.11 3.29e-27 1.31e-26
21FLT1, MECOM, LDB2, EGFL7, PREX2, ANO2, WWTR1, CALCRL, EMCN, ADAMTS9, VWF, MYCT1, RHOJ, PLVAP, PALMD, COL4A1, ERG, ID1, KDR, RASGRP3, ADCY4
 131
MURARO_PANCREAS_ENDOTHELIAL_CELL 3.95e-36 61.77 33.38 1.32e-33 2.65e-33
31FLT1, MECOM, LDB2, MEF2C, WWTR1, CALCRL, EMCN, ADAMTS9, STC1, VWF, INSR, ESM1, EMP1, MYCT1, RHOJ, NOTCH4, TM4SF1, PLVAP, PLEKHG1, COL4A1, ERG, IGFBP7, GRB10, ID1, TGFBR2, COL4A2, CDH5, KDR, PTPRE, RASGRP3, CYYR1
 362
DESCARTES_FETAL_INTESTINE_VASCULAR_ENDOTHELIAL_CELLS 5.85e-14 80.23 31.85 1.96e-12 3.92e-11
9FLT1, DLL4, EMCN, HSPG2, ESM1, NOTCH4, PLVAP, BTNL9, CYYR1
 43
AIZARANI_LIVER_C29_MVECS_2 2.80e-29 47.20 25.69 3.76e-27 1.88e-26
26FLT1, MECOM, LDB2, PREX2, WWTR1, CALCRL, EMCN, ADAMTS9, STC1, VWF, INSR, EMP1, MYCT1, RHOJ, NOTCH4, TM4SF1, PLVAP, PALMD, MAST4, CRIM1, ERG, IGFBP7, ID1, CDH5, PTPRG, CYYR1
 313
CUI_DEVELOPING_HEART_C4_ENDOTHELIAL_CELL 2.96e-21 49.84 25.37 1.98e-19 1.98e-18
17FLT1, LDB2, EGFL7, WWTR1, CALCRL, EMCN, ADAMTS9, VWF, MYCT1, HES1, TM4SF1, PLVAP, PALMD, ID1, CDH5, KDR, CYYR1
 146
AIZARANI_LIVER_C9_LSECS_1 6.14e-28 44.81 24.36 6.87e-26 4.12e-25
25FLT1, LDB2, EGFL7, PREX2, MEF2C, WWTR1, ADAMTS9, STC1, INSR, EMP1, MYCT1, HES1, RHOJ, NOTCH4, TM4SF1, PLEKHG1, CRIM1, COL4A1, ERG, IGFBP7, GRB10, COL4A2, CDH5, KDR, BTNL9
 304
MANNO_MIDBRAIN_NEUROTYPES_HENDO 3.89e-35 46.65 23.77 8.70e-33 2.61e-32
38FLT1, MECOM, DLL4, LDB2, EGFL7, MEF2C, WWTR1, CALCRL, EMCN, HSPG2, VWF, INSR, ESM1, EMP1, MYCT1, VEGFC, HES1, RHOJ, TM4SF1, PLVAP, PALMD, PLEKHG1, MAST4, DYSF, CRIM1, ERG, IGFBP7, SAT1, ID1, TGFBR2, CDH5, KDR, FLI1, RASGRP3, PTPRG, BTNL9, ADCY4, CYYR1
 888
GAO_LARGE_INTESTINE_24W_C2_MKI67POS_PROGENITOR 6.37e-18 49.02 23.66 3.56e-16 4.27e-15
14FLT1, LDB2, EGFL7, CALCRL, EMCN, VWF, MYCT1, TM4SF1, PLVAP, PALMD, ERG, CDH5, KDR, CYYR1
 113
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_PERICYTES 8.57e-15 51.81 22.91 3.38e-13 5.75e-12
11FLT1, EGFL7, CALCRL, EMCN, VWF, EMP1, TM4SF1, PLVAP, PALMD, TGFBR2, CYYR1
 79
AIZARANI_LIVER_C20_LSECS_3 5.30e-25 39.15 21.14 4.45e-23 3.56e-22
23FLT1, LDB2, PREX2, WWTR1, ADAMTS9, STC1, INSR, EMP1, MYCT1, RHOJ, NOTCH4, TM4SF1, PLEKHG1, MAST4, CRIM1, COL4A1, ERG, IGFBP7, GRB10, COL4A2, CDH5, KDR, BTNL9
 295
DESCARTES_FETAL_MUSCLE_VASCULAR_ENDOTHELIAL_CELLS 1.89e-13 49.55 21.14 5.51e-12 1.27e-10
10FLT1, DLL4, ANO2, ESM1, VEGFC, NOTCH4, TM4SF1, PLVAP, BTNL9, CYYR1
 73
DESCARTES_FETAL_EYE_VASCULAR_ENDOTHELIAL_CELLS 3.79e-14 44.55 19.83 1.34e-12 2.54e-11
11FLT1, EGFL7, ARL15, CALCRL, VWF, MYCT1, NOTCH4, PLVAP, ERG, CDH5, ADCY4
 90
RUBENSTEIN_SKELETAL_MUSCLE_ENDOTHELIAL_CELLS 1.00e-16 39.48 19.17 4.81e-15 6.74e-14
14FLT1, EGFL7, MEF2C, EMCN, HSPG2, VWF, MYCT1, TM4SF1, PALMD, COL4A1, ID1, COL4A2, CDH5, BTNL9
 137
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_1 1.66e-25 32.73 17.89 1.59e-23 1.11e-22
26FLT1, MECOM, DLL4, EGFL7, PREX2, WWTR1, CALCRL, EMCN, VWF, INSR, MYCT1, HES1, RHOJ, NOTCH4, TM4SF1, PALMD, PLEKHG1, ERG, IGFBP7, ID1, CDH5, KDR, RASGRP3, PTPRG, ADCY4, CYYR1
 440
MENON_FETAL_KIDNEY_9_ENDOTHELIAL_CELLS 1.55e-13 38.65 17.31 4.73e-12 1.04e-10
11FLT1, EGFL7, MEF2C, EMCN, HSPG2, NOTCH4, TM4SF1, COL4A1, TGFBR2, COL4A2, KDR
 102
LAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR 4.36e-16 35.20 17.13 1.95e-14 2.93e-13
14FLT1, LDB2, EGFL7, MEF2C, ARL15, WWTR1, EMCN, ADAMTS9, EMP1, TM4SF1, PALMD, CRIM1, ID1, PTPRG
 152
FAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL 6.47e-23 31.17 16.87 4.82e-21 4.34e-20
23FLT1, MECOM, EGFL7, WWTR1, EMCN, VWF, MYCT1, HES1, RHOJ, NOTCH4, TM4SF1, COL4A1, ERG, IGFBP7, ID1, TGFBR2, COL4A2, CDH5, KDR, FLI1, RASGRP3, ADCY4, CYYR1
 365
AIZARANI_LIVER_C13_LSECS_2 9.86e-21 31.66 16.82 6.01e-19 6.61e-18
20FLT1, LDB2, EGFL7, PREX2, CALCRL, EMCN, INSR, MYCT1, HES1, NOTCH4, TM4SF1, COL4A1, ERG, IGFBP7, ID1, TGFBR2, COL4A2, CDH5, KDR, BTNL9
 283
DESCARTES_FETAL_STOMACH_VASCULAR_ENDOTHELIAL_CELLS 1.07e-07 55.36 15.85 2.05e-06 7.17e-05
5FLT1, EMCN, NOTCH4, PLVAP, CYYR1
 30

Dowload full table

mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_MYOGENESIS 7.71e-03 5.55 1.44 1.93e-01 3.85e-01
4MEF2C, WWTR1, IGFBP7, COL4A2
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 7.71e-03 5.55 1.44 1.93e-01 3.85e-01
4VEGFC, COL4A1, SAT1, COL4A2
 200
HALLMARK_TGF_BETA_SIGNALING 1.94e-02 10.01 1.15 3.23e-01 9.68e-01
2WWTR1, ID1
 54
HALLMARK_TNFA_SIGNALING_VIA_NFKB 4.35e-02 4.05 0.80 4.35e-01 1.00e+00
3HES1, SAT1, PTPRE
 200
HALLMARK_P53_PATHWAY 4.35e-02 4.05 0.80 4.35e-01 1.00e+00
3TM4SF1, SAT1, PTPRE
 200
HALLMARK_UV_RESPONSE_DN 1.10e-01 3.67 0.43 6.60e-01 1.00e+00
2ID1, TGFBR2
 144
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 6.60e-01 1.00e+00
2EMP1, SAT1
 161
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.85e-01 2.63 0.31 6.60e-01 1.00e+00
2HES1, MAST4
 200
HALLMARK_COMPLEMENT 1.85e-01 2.63 0.31 6.60e-01 1.00e+00
2NOTCH4, COL4A2
 200
HALLMARK_INFLAMMATORY_RESPONSE 1.85e-01 2.63 0.31 6.60e-01 1.00e+00
2CALCRL, PTPRE
 200
HALLMARK_KRAS_SIGNALING_UP 1.85e-01 2.63 0.31 6.60e-01 1.00e+00
2EMP1, PLVAP
 200
HALLMARK_NOTCH_SIGNALING 1.20e-01 8.23 0.20 6.60e-01 1.00e+00
1HES1
 32
HALLMARK_ANGIOGENESIS 1.34e-01 7.29 0.18 6.60e-01 1.00e+00
1STC1
 36
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.54e-01 6.22 0.15 6.60e-01 1.00e+00
1NOTCH4
 42
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 1.00e+00 1.00e+00
1SAT1
 100
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 1.00e+00 1.00e+00
1VWF
 138
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1PTPRG
 158
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1EMP1
 199
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1STC1
 200
HALLMARK_ADIPOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1COL4A1
 200

Dowload full table

KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_NOTCH_SIGNALING_PATHWAY 8.44e-04 18.11 3.48 5.23e-02 1.57e-01
3DLL4, HES1, NOTCH4
 47
KEGG_ECM_RECEPTOR_INTERACTION 3.32e-04 13.58 3.47 3.09e-02 6.17e-02
4HSPG2, VWF, COL4A1, COL4A2
 84
KEGG_FOCAL_ADHESION 1.20e-04 8.83 3.04 2.24e-02 2.24e-02
6FLT1, VWF, VEGFC, COL4A1, COL4A2, KDR
 199
KEGG_PATHWAYS_IN_CANCER 8.32e-03 4.34 1.34 3.87e-01 1.00e+00
5MECOM, VEGFC, COL4A1, TGFBR2, COL4A2
 325
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 1.96e-02 4.16 1.08 6.21e-01 1.00e+00
4FLT1, VEGFC, TGFBR2, KDR
 265
KEGG_MAPK_SIGNALING_PATHWAY 2.00e-02 4.13 1.07 6.21e-01 1.00e+00
4MECOM, MEF2C, TGFBR2, RASGRP3
 267
KEGG_PANCREATIC_CANCER 3.13e-02 7.66 0.88 6.99e-01 1.00e+00
2VEGFC, TGFBR2
 70
KEGG_ADHERENS_JUNCTION 3.38e-02 7.33 0.85 6.99e-01 1.00e+00
2INSR, TGFBR2
 73
KEGG_CHRONIC_MYELOID_LEUKEMIA 3.38e-02 7.33 0.85 6.99e-01 1.00e+00
2MECOM, TGFBR2
 73
KEGG_SMALL_CELL_LUNG_CANCER 4.36e-02 6.35 0.74 7.68e-01 1.00e+00
2COL4A1, COL4A2
 84
KEGG_TGF_BETA_SIGNALING_PATHWAY 4.54e-02 6.20 0.72 7.68e-01 1.00e+00
2ID1, TGFBR2
 86
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 7.56e-02 4.61 0.54 1.00e+00 1.00e+00
2CALCRL, ADCY4
 115
KEGG_PURINE_METABOLISM 1.29e-01 3.32 0.39 1.00e+00 1.00e+00
2PDE4D, ADCY4
 159
KEGG_ENDOCYTOSIS 1.59e-01 2.91 0.34 1.00e+00 1.00e+00
2FLT1, KDR
 181
KEGG_DORSO_VENTRAL_AXIS_FORMATION 9.13e-02 11.08 0.26 1.00e+00 1.00e+00
1NOTCH4
 24
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 9.49e-02 10.62 0.25 1.00e+00 1.00e+00
1HES1
 25
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1INSR
 42
KEGG_BLADDER_CANCER 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1VEGFC
 42
KEGG_TYPE_II_DIABETES_MELLITUS 1.71e-01 5.54 0.13 1.00e+00 1.00e+00
1INSR
 47
KEGG_TASTE_TRANSDUCTION 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1ADCY4
 52

Dowload full table

CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr5q12 2.50e-02 8.68 1.00 1.00e+00 1.00e+00
2MAST4, PDE4D
 62
chr4q12 3.90e-02 6.76 0.78 1.00e+00 1.00e+00
2IGFBP7, KDR
 79
chr5q11 4.45e-02 6.27 0.73 1.00e+00 1.00e+00
2ARL15, ESM1
 85
chr2p22 5.73e-02 5.42 0.63 1.00e+00 1.00e+00
2CRIM1, RASGRP3
 98
chr3p14 8.36e-02 4.34 0.51 1.00e+00 1.00e+00
2ADAMTS9, PTPRG
 122
chr12p13 1.39e-01 2.42 0.48 1.00e+00 1.00e+00
3ANO2, VWF, EMP1
 333
chr3q25 1.20e-01 3.47 0.41 1.00e+00 1.00e+00
2WWTR1, TM4SF1
 152
chr6q25 1.23e-01 3.43 0.40 1.00e+00 1.00e+00
2MYCT1, PLEKHG1
 154
chr4q24 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1EMCN
 56
chr7p12 2.06e-01 4.47 0.11 1.00e+00 1.00e+00
1GRB10
 58
chr5q15 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1MCTP1
 60
chr8q13 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1PREX2
 71
chr16q21 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1CDH5
 74
chr19p13 1.00e+00 0.68 0.08 1.00e+00 1.00e+00
2INSR, PLVAP
 773
chr1p21 3.25e-01 2.60 0.06 1.00e+00 1.00e+00
1PALMD
 99
chr3p24 3.25e-01 2.60 0.06 1.00e+00 1.00e+00
1TGFBR2
 99
chr14q12 3.31e-01 2.55 0.06 1.00e+00 1.00e+00
1ADCY4
 101
chr2q32 3.49e-01 2.38 0.06 1.00e+00 1.00e+00
1CALCRL
 108
chr21q21 3.77e-01 2.16 0.05 1.00e+00 1.00e+00
1CYYR1
 119
chr3q29 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1HES1
 122

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
STAT6_02 6.64e-06 9.45 3.79 3.12e-03 7.53e-03
8FLT1, EGFL7, MEF2C, RHOJ, NOTCH4, ERG, FLI1, PDE4D
 260
STAT4_01 8.26e-06 9.16 3.68 3.12e-03 9.36e-03
8FLT1, MECOM, MEF2C, RHOJ, NOTCH4, ERG, FLI1, PDE4D
 268
GATA1_05 1.25e-05 8.63 3.47 3.54e-03 1.42e-02
8MECOM, EGFL7, STC1, MYCT1, HES1, ERG, FLI1, PTPRG
 284
RYTTCCTG_ETS2_B 1.99e-07 5.89 3.06 2.26e-04 2.26e-04
17FLT1, DLL4, LDB2, EGFL7, MEF2C, CALCRL, MYCT1, RHOJ, NOTCH4, ERG, GRB10, TGFBR2, CDH5, PDE4D, RASGRP3, PTPRG, ADCY4
 1112
FOXJ2_02 3.49e-04 7.19 2.48 5.98e-02 3.95e-01
6MECOM, CRIM1, ERG, IGFBP7, ID1, PDE4D
 243
YRCCAKNNGNCGC_UNKNOWN 2.25e-03 12.65 2.46 1.50e-01 1.00e+00
3DLL4, HES1, PTPRE
 66
NFAT_Q6 3.96e-04 7.01 2.42 5.98e-02 4.49e-01
6DLL4, PREX2, HSPG2, EMP1, ERG, PDE4D
 249
IRF7_01 4.77e-04 6.76 2.33 5.98e-02 5.40e-01
6DLL4, LDB2, ERG, SAT1, FLI1, PDE4D
 258
CEBPGAMMA_Q6 4.86e-04 6.74 2.32 5.98e-02 5.51e-01
6LDB2, MEF2C, STC1, FLI1, RASGRP3, PTPRG
 259
OCT1_06 5.80e-04 6.51 2.25 5.98e-02 6.58e-01
6MECOM, LDB2, STC1, PALMD, SAT1, PDE4D
 268
HFH3_01 9.88e-04 7.27 2.23 8.84e-02 1.00e+00
5MEF2C, PALMD, CRIM1, ID1, FLI1
 196
GNCF_01 3.61e-03 10.64 2.07 1.59e-01 1.00e+00
3FLT1, MEF2C, INSR
 78
HNF3ALPHA_Q6 1.36e-03 6.74 2.07 1.03e-01 1.00e+00
5MEF2C, PALMD, ID1, PDE4D, PTPRG
 211
GATAAGR_GATA_C 1.01e-03 5.82 2.01 8.84e-02 1.00e+00
6MECOM, MEF2C, STC1, MYCT1, ERG, FLI1
 299
ALX4_TARGET_GENES 7.12e-03 17.34 1.95 2.24e-01 1.00e+00
2MEF2C, PDE4D
 32
TGANTCA_AP1_C 1.65e-04 3.90 1.90 3.73e-02 1.87e-01
13MECOM, MEF2C, HSPG2, STC1, MCTP1, EMP1, NOTCH4, DYSF, SAT1, TGFBR2, CDH5, FLI1, PDE4D
 1139
FREAC4_01 3.03e-03 7.29 1.88 1.51e-01 1.00e+00
4HSPG2, EMP1, MAST4, ERG
 153
BRN2_01 2.38e-03 5.91 1.81 1.50e-01 1.00e+00
5MECOM, RHOJ, ERG, SAT1, PTPRG
 240
GATA1_03 2.64e-03 5.76 1.77 1.51e-01 1.00e+00
5MECOM, MEF2C, HES1, ERG, RASGRP3
 246
ELF1_Q6 2.78e-03 5.69 1.75 1.51e-01 1.00e+00
5CALCRL, ESM1, SAT1, CDH5, RASGRP3
 249

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_BRANCHING_INVOLVED_IN_BLOOD_VESSEL_MORPHOGENESIS 2.06e-07 47.76 13.82 1.92e-04 1.54e-03
5DLL4, NOTCH4, COL4A1, TGFBR2, KDR
 34
GOBP_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION 8.35e-04 57.69 5.91 1.21e-01 1.00e+00
2NOTCH4, ID1
 11
GOBP_RETINA_VASCULATURE_MORPHOGENESIS_IN_CAMERA_TYPE_EYE 8.35e-04 57.69 5.91 1.21e-01 1.00e+00
2RHOJ, COL4A1
 11
GOBP_ENDOTHELIUM_DEVELOPMENT 9.96e-07 15.65 5.83 6.14e-04 7.45e-03
7DLL4, STC1, NOTCH4, ID1, CDH5, KDR, PDE4D
 137
GOBP_BLOOD_VESSEL_MORPHOGENESIS 1.80e-11 10.68 5.61 7.04e-08 1.35e-07
18FLT1, DLL4, EGFL7, CALCRL, ADAMTS9, HSPG2, ESM1, VEGFC, HES1, RHOJ, NOTCH4, COL4A1, SAT1, ID1, TGFBR2, COL4A2, CDH5, KDR
 677
GOBP_COLLAGEN_ACTIVATED_TYROSINE_KINASE_RECEPTOR_SIGNALING_PATHWAY 9.99e-04 51.89 5.39 1.30e-01 1.00e+00
2COL4A1, COL4A2
 12
GOBP_VASCULATURE_DEVELOPMENT 1.88e-11 10.00 5.31 7.04e-08 1.41e-07
19FLT1, DLL4, EGFL7, MEF2C, CALCRL, ADAMTS9, HSPG2, ESM1, VEGFC, HES1, RHOJ, NOTCH4, COL4A1, SAT1, ID1, TGFBR2, COL4A2, CDH5, KDR
 786
GOBP_AORTA_MORPHOGENESIS 2.96e-04 26.56 5.01 6.16e-02 1.00e+00
3DLL4, ADAMTS9, HES1
 33
GOBP_ENDOTHELIAL_CELL_MORPHOGENESIS 1.18e-03 47.19 4.96 1.42e-01 1.00e+00
2STC1, NOTCH4
 13
GOBP_HEART_VALVE_DEVELOPMENT 9.66e-05 19.05 4.82 2.58e-02 7.23e-01
4DLL4, MEF2C, ADAMTS9, TGFBR2
 61
GOBP_TUBE_MORPHOGENESIS 1.68e-10 8.71 4.63 4.20e-07 1.26e-06
19FLT1, DLL4, EGFL7, MEF2C, CALCRL, ADAMTS9, HSPG2, ESM1, VEGFC, HES1, RHOJ, NOTCH4, COL4A1, SAT1, ID1, TGFBR2, COL4A2, CDH5, KDR
 900
GOBP_TISSUE_MIGRATION 1.10e-07 9.96 4.56 1.18e-04 8.23e-04
11DLL4, MEF2C, ADAMTS9, STC1, VEGFC, RHOJ, ID1, TGFBR2, CDH5, KDR, PTPRG
 365
GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION 5.01e-06 12.11 4.53 2.34e-03 3.75e-02
7DLL4, MEF2C, VEGFC, RHOJ, ID1, CDH5, KDR
 175
GOBP_ENDOTHELIAL_CELL_DEVELOPMENT 1.31e-04 17.51 4.45 3.28e-02 9.83e-01
4STC1, NOTCH4, CDH5, PDE4D
 66
GOBP_ENDOTHELIAL_CELL_MIGRATION 1.07e-06 10.20 4.31 6.14e-04 7.98e-03
9DLL4, MEF2C, ADAMTS9, STC1, VEGFC, RHOJ, ID1, CDH5, KDR
 278
GOBP_GROWTH_PLATE_CARTILAGE_DEVELOPMENT 1.58e-03 39.95 4.27 1.66e-01 1.00e+00
2STC1, TGFBR2
 15
GOBP_COLLAGEN_ACTIVATED_SIGNALING_PATHWAY 1.58e-03 39.95 4.27 1.66e-01 1.00e+00
2COL4A1, COL4A2
 15
GOBP_HEMATOPOIETIC_STEM_CELL_HOMEOSTASIS 1.58e-03 39.95 4.27 1.66e-01 1.00e+00
2EMCN, MYCT1
 15
GOBP_NEPHRON_TUBULE_EPITHELIAL_CELL_DIFFERENTIATION 1.58e-03 39.95 4.27 1.66e-01 1.00e+00
2MEF2C, WWTR1
 15
GOBP_TUBE_DEVELOPMENT 4.09e-10 7.83 4.20 7.66e-07 3.06e-06
20FLT1, DLL4, EGFL7, MEF2C, WWTR1, CALCRL, ADAMTS9, HSPG2, ESM1, VEGFC, HES1, RHOJ, NOTCH4, COL4A1, SAT1, ID1, TGFBR2, COL4A2, CDH5, KDR
 1085

Dowload full table

Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_UP 9.73e-07 12.40 4.96 4.74e-03 4.74e-03
8LDB2, RHOJ, TM4SF1, COL4A1, COL4A2, CDH5, KDR, ADCY4
 200
GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_30MIN_UP 1.14e-04 8.92 3.07 1.90e-01 5.55e-01
6CALCRL, EMP1, MYCT1, NOTCH4, MAST4, CYYR1
 197
GSE6259_BCELL_VS_CD8_TCELL_DN 1.17e-04 8.88 3.05 1.90e-01 5.71e-01
6MYCT1, HES1, ERG, GRB10, COL4A2, PTPRE
 198
GSE6259_33D1_POS_VS_DEC205_POS_SPLENIC_DC_UP 9.23e-04 7.39 2.26 5.84e-01 1.00e+00
5MEF2C, MYCT1, HES1, ERG, ADCY4
 193
GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP 9.44e-04 7.35 2.25 5.84e-01 1.00e+00
5MECOM, WWTR1, MYCT1, NOTCH4, ERG
 194
GSE43863_NAIVE_VS_TFH_CD4_EFF_TCELL_D6_LCMV_UP 9.88e-04 7.27 2.23 5.84e-01 1.00e+00
5LDB2, EMP1, RHOJ, ID1, PTPRE
 196
GSE22229_UNTREATED_VS_IMMUNOSUPP_THERAPY_RENAL_TRANSPLANT_PATIENT_PBMC_DN 1.06e-03 7.16 2.19 5.84e-01 1.00e+00
5MYCT1, COL4A1, GRB10, COL4A2, BTNL9
 199
GSE3039_CD4_TCELL_VS_B2_BCELL_UP 1.08e-03 7.12 2.18 5.84e-01 1.00e+00
5ARL15, MCTP1, ERG, PDE4D, BTNL9
 200
GSE21774_CD56_BRIGHT_VS_DIM_CD62L_POSITIVE_NK_CELL_UP 1.08e-03 7.12 2.18 5.84e-01 1.00e+00
5MECOM, VWF, INSR, MAST4, GRB10
 200
GSE40274_CTRL_VS_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP 4.49e-03 6.51 1.68 9.16e-01 1.00e+00
4CALCRL, HES1, MAST4, CDH5
 171
GSE26488_CTRL_VS_PEPTIDE_INJECTION_OT2_THYMOCYTE_DN 5.68e-03 6.07 1.57 9.16e-01 1.00e+00
4MEF2C, ID1, FLI1, RASGRP3
 183
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_UP 5.90e-03 6.00 1.55 9.16e-01 1.00e+00
4TM4SF1, ID1, PDE4D, CYYR1
 185
GSE4748_CYANOBACTERIUM_LPSLIKE_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_DN 6.95e-03 5.72 1.48 9.16e-01 1.00e+00
4STC1, DYSF, ERG, ADCY4
 194
GSE1460_INTRATHYMIC_T_PROGENITOR_VS_DP_THYMOCYTE_DN 7.32e-03 5.63 1.46 9.16e-01 1.00e+00
4VEGFC, MAST4, TGFBR2, PDE4D
 197
GSE22886_NAIVE_TCELL_VS_NKCELL_DN 7.32e-03 5.63 1.46 9.16e-01 1.00e+00
4LDB2, CRIM1, IGFBP7, PTPRE
 197
GSE36888_UNTREATED_VS_IL2_TREATED_TCELL_2H_UP 7.32e-03 5.63 1.46 9.16e-01 1.00e+00
4HES1, NOTCH4, PLVAP, SAT1
 197
GSE22886_TH1_VS_TH2_48H_ACT_UP 7.45e-03 5.60 1.45 9.16e-01 1.00e+00
4PREX2, VWF, EMP1, ERG
 198
GSE21670_UNTREATED_VS_TGFB_TREATED_CD4_TCELL_DN 7.45e-03 5.60 1.45 9.16e-01 1.00e+00
4MYCT1, COL4A1, TGFBR2, COL4A2
 198
GSE3039_B2_VS_B1_BCELL_UP 7.58e-03 5.57 1.44 9.16e-01 1.00e+00
4ARL15, HES1, CRIM1, RASGRP3
 199
GSE5589_WT_VS_IL6_KO_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_DN 7.58e-03 5.57 1.44 9.16e-01 1.00e+00
4TM4SF1, COL4A1, GRB10, COL4A2
 199

Dowload full table

Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MECOM 2 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
PREX2 6 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MEF2C 7 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
WWTR1 10 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-activator that binds to TEADs (PMID: 19324877) and TBX5 (PMID: 16332960)
HES1 23 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ERG 34 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ID1 38 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
FLI1 43 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FOSL1 59 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZFP36 61 No ssDNA/RNA binding Not a DNA binding protein No motif None RNA binding protein (PMID: 10330172).
ETS1 71 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
EDN1 74 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that is processed into a secreted signaling peptide
PRKCH 75 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase that activates another kinase leading to degradation of NFKB inhibitor NFKBIA (PMID: 21820409)
PLXND1 76 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade.
FOXO1 78 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
EPAS1 95 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
RAPGEF5 98 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NFIA 111 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ELK3 116 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TCF7L1 124 Yes Known motif Monomer or homomultimer High-throughput in vitro None None

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB09_GGCGACTGTAAATACG-1 Neurons:adrenal_medulla_cell_line 0.10 1410.10
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.27, Endothelial_cells:lymphatic: 0.27, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.26, Endothelial_cells:HUVEC: 0.26, Endothelial_cells:blood_vessel: 0.26, Endothelial_cells:HUVEC:B._anthracis_LT: 0.25, Endothelial_cells:lymphatic:KSHV: 0.25, Endothelial_cells:HUVEC:IL-1b: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25
NB09_TTGGCAAGTCAGAAGC-1 Endothelial_cells:blood_vessel 0.13 1095.57
Raw ScoresEndothelial_cells:lymphatic: 0.28, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.27, Endothelial_cells:HUVEC:VEGF: 0.27, Endothelial_cells:lymphatic:KSHV: 0.26, Endothelial_cells:HUVEC: 0.26, Endothelial_cells:blood_vessel: 0.26, Endothelial_cells:HUVEC:IL-1b: 0.25, Endothelial_cells:HUVEC:B._anthracis_LT: 0.25, Endothelial_cells:HUVEC:H5N1-infected: 0.24
NB14_ATGAGGGTCCCGGATG-1 Endothelial_cells:lymphatic:KSHV 0.16 979.92
Raw ScoresEndothelial_cells:lymphatic: 0.3, Endothelial_cells:HUVEC:VEGF: 0.3, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.29, Endothelial_cells:lymphatic:KSHV: 0.29, Endothelial_cells:lymphatic:TNFa_48h: 0.29, Endothelial_cells:HUVEC: 0.29, Endothelial_cells:blood_vessel: 0.29, Endothelial_cells:HUVEC:IL-1b: 0.27, Endothelial_cells:HUVEC:B._anthracis_LT: 0.27, iPS_cells:CRL2097_foreskin: 0.27
NB11_CGCGGTAGTATCGCAT-1 Endothelial_cells:blood_vessel 0.16 868.45
Raw ScoresEndothelial_cells:lymphatic: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.26, Endothelial_cells:blood_vessel: 0.26, Endothelial_cells:lymphatic:KSHV: 0.26, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.25, Endothelial_cells:HUVEC:VEGF: 0.24, Endothelial_cells:HUVEC: 0.23, Endothelial_cells:HUVEC:IL-1b: 0.23, Endothelial_cells:HUVEC:B._anthracis_LT: 0.23, Endothelial_cells:HUVEC:FPV-infected: 0.22
NB09_CTGAAACCAAAGCAAT-1 Neurons:adrenal_medulla_cell_line 0.12 729.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, Endothelial_cells:HUVEC:VEGF: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.25, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.25, Endothelial_cells:HUVEC: 0.24, Endothelial_cells:lymphatic: 0.24, Endothelial_cells:lymphatic:TNFa_48h: 0.24, Endothelial_cells:blood_vessel: 0.23
NB08_CGTCAGGAGTTAGCGG-1 Endothelial_cells:HUVEC:VEGF 0.16 669.61
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.29, Endothelial_cells:lymphatic:TNFa_48h: 0.29, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.28, Endothelial_cells:HUVEC: 0.28, Endothelial_cells:lymphatic: 0.28, Endothelial_cells:HUVEC:IFNg: 0.28, Endothelial_cells:HUVEC:H5N1-infected: 0.27, Endothelial_cells:HUVEC:B._anthracis_LT: 0.27, Endothelial_cells:HUVEC:PR8-infected: 0.27, Endothelial_cells:HUVEC:IL-1b: 0.27
NB09_AGGTCATCAGCATGAG-1 Endothelial_cells:lymphatic:KSHV 0.13 647.58
Raw ScoresEndothelial_cells:lymphatic: 0.24, Endothelial_cells:lymphatic:KSHV: 0.23, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.23, Endothelial_cells:blood_vessel: 0.23, Endothelial_cells:lymphatic:TNFa_48h: 0.23, Endothelial_cells:HUVEC:VEGF: 0.22, Endothelial_cells:HUVEC: 0.22, Endothelial_cells:HUVEC:IL-1b: 0.21, Endothelial_cells:HUVEC:B._anthracis_LT: 0.21, Endothelial_cells:HUVEC:FPV-infected: 0.2
NB12_TGTCCCACATGGTCAT-1 Endothelial_cells:lymphatic:TNFa_48h 0.19 604.04
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.3, Endothelial_cells:lymphatic: 0.3, Endothelial_cells:HUVEC:VEGF: 0.29, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.27, Endothelial_cells:HUVEC: 0.27, Endothelial_cells:HUVEC:B._anthracis_LT: 0.26, Endothelial_cells:HUVEC:H5N1-infected: 0.26, Endothelial_cells:HUVEC:IL-1b: 0.26, Endothelial_cells:HUVEC:FPV-infected: 0.25, Endothelial_cells:HUVEC:PR8-infected: 0.25
NB08_ATCATGGGTGACAAAT-1 Endothelial_cells:lymphatic:TNFa_48h 0.13 502.27
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.28, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.27, Endothelial_cells:HUVEC: 0.27, Endothelial_cells:HUVEC:H5N1-infected: 0.27, Endothelial_cells:HUVEC:IL-1b: 0.26, Endothelial_cells:lymphatic: 0.26, Endothelial_cells:HUVEC:PR8-infected: 0.26, Endothelial_cells:HUVEC:IFNg: 0.26, Endothelial_cells:HUVEC:B._anthracis_LT: 0.25
NB05_CCATTCGAGATCTGCT-1 Endothelial_cells:lymphatic 0.14 461.24
Raw ScoresEndothelial_cells:lymphatic: 0.23, Endothelial_cells:lymphatic:TNFa_48h: 0.23, Endothelial_cells:HUVEC:VEGF: 0.22, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.22, Endothelial_cells:blood_vessel: 0.21, Endothelial_cells:lymphatic:KSHV: 0.21, Endothelial_cells:HUVEC: 0.21, Endothelial_cells:HUVEC:IL-1b: 0.2, Endothelial_cells:HUVEC:B._anthracis_LT: 0.2, Endothelial_cells:HUVEC:PR8-infected: 0.19
NB09_TACCTTAGTGTAATGA-1 Neurons:adrenal_medulla_cell_line 0.08 410.68
Raw ScoresEndothelial_cells:lymphatic: 0.21, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.21, Endothelial_cells:lymphatic:TNFa_48h: 0.21, Endothelial_cells:HUVEC:VEGF: 0.2, Endothelial_cells:blood_vessel: 0.2, Endothelial_cells:HUVEC: 0.2, Endothelial_cells:lymphatic:KSHV: 0.2, Endothelial_cells:HUVEC:IL-1b: 0.2, Endothelial_cells:HUVEC:B._anthracis_LT: 0.19, Endothelial_cells:HUVEC:H5N1-infected: 0.18
NB11_TGCTACCCATCCGGGT-1 Endothelial_cells:lymphatic:TNFa_48h 0.14 391.40
Raw ScoresEndothelial_cells:lymphatic: 0.24, Endothelial_cells:lymphatic:TNFa_48h: 0.24, Endothelial_cells:blood_vessel: 0.23, Endothelial_cells:lymphatic:KSHV: 0.22, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.22, Endothelial_cells:HUVEC:VEGF: 0.22, Endothelial_cells:HUVEC: 0.21, Endothelial_cells:HUVEC:IL-1b: 0.21, Endothelial_cells:HUVEC:B._anthracis_LT: 0.21, Endothelial_cells:HUVEC:H5N1-infected: 0.2
NB13_ATTCTACAGGCATTGG-1 Endothelial_cells:lymphatic 0.10 328.65
Raw ScoresEndothelial_cells:lymphatic: 0.18, Endothelial_cells:lymphatic:TNFa_48h: 0.18, Endothelial_cells:HUVEC:VEGF: 0.17, Endothelial_cells:HUVEC: 0.17, Endothelial_cells:HUVEC:IFNg: 0.16, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.16, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.16, Endothelial_cells:blood_vessel: 0.16, Endothelial_cells:HUVEC:H5N1-infected: 0.16, Fibroblasts:breast: 0.16
NB13_GTCATTTAGGACGAAA-1 Endothelial_cells:lymphatic:TNFa_48h 0.12 324.30
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.22, Endothelial_cells:lymphatic: 0.22, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.21, Endothelial_cells:blood_vessel: 0.2, Endothelial_cells:HUVEC: 0.2, Endothelial_cells:HUVEC:VEGF: 0.2, Endothelial_cells:HUVEC:IFNg: 0.2, Endothelial_cells:HUVEC:IL-1b: 0.2, Endothelial_cells:HUVEC:H5N1-infected: 0.19, Endothelial_cells:HUVEC:B._anthracis_LT: 0.19
NB11_ACAGCTAGTCTGCCAG-1 Tissue_stem_cells:BM_MSC 0.12 320.40
Raw ScoresEndothelial_cells:lymphatic: 0.23, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.22, Endothelial_cells:lymphatic:KSHV: 0.22, Endothelial_cells:blood_vessel: 0.22, Endothelial_cells:lymphatic:TNFa_48h: 0.22, Endothelial_cells:HUVEC:VEGF: 0.22, Endothelial_cells:HUVEC: 0.22, Osteoblasts: 0.21, Osteoblasts:BMP2: 0.21, Smooth_muscle_cells:vascular: 0.21
NB13_CTGATCCAGCCGCCTA-1 Endothelial_cells:lymphatic:TNFa_48h 0.12 312.83
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.23, Endothelial_cells:HUVEC:VEGF: 0.22, Endothelial_cells:lymphatic: 0.22, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.22, Endothelial_cells:HUVEC: 0.22, Endothelial_cells:blood_vessel: 0.21, Endothelial_cells:HUVEC:IFNg: 0.21, Endothelial_cells:HUVEC:IL-1b: 0.21, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.21, Endothelial_cells:HUVEC:H5N1-infected: 0.21
NB12_CAGTAACTCCGATATG-1 Smooth_muscle_cells:vascular 0.16 305.03
Raw ScoresiPS_cells:CRL2097_foreskin: 0.26, Fibroblasts:breast: 0.25, Smooth_muscle_cells:vascular: 0.25, Smooth_muscle_cells:bronchial: 0.25, Smooth_muscle_cells:vascular:IL-17: 0.25, Smooth_muscle_cells:bronchial:vit_D: 0.25, Osteoblasts: 0.24, Osteoblasts:BMP2: 0.24, iPS_cells:adipose_stem_cells: 0.24, MSC: 0.24
NB12_TGATTTCCAAGTCTGT-1 Endothelial_cells:lymphatic 0.17 268.88
Raw ScoresEndothelial_cells:lymphatic: 0.26, Endothelial_cells:lymphatic:TNFa_48h: 0.26, Endothelial_cells:HUVEC:VEGF: 0.25, Endothelial_cells:HUVEC: 0.23, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.23, Endothelial_cells:HUVEC:IL-1b: 0.22, Endothelial_cells:HUVEC:H5N1-infected: 0.22, Endothelial_cells:HUVEC:B._anthracis_LT: 0.22, Endothelial_cells:HUVEC:FPV-infected: 0.22, Endothelial_cells:HUVEC:PR8-infected: 0.22
NB14_TTCTCAACATCCCACT-1 iPS_cells:adipose_stem_cells 0.14 261.82
Raw ScoresiPS_cells:CRL2097_foreskin: 0.24, Smooth_muscle_cells:bronchial: 0.24, Osteoblasts: 0.24, Chondrocytes:MSC-derived: 0.24, MSC: 0.23, Tissue_stem_cells:BM_MSC:TGFb3: 0.23, Fibroblasts:breast: 0.23, Smooth_muscle_cells:bronchial:vit_D: 0.23, Smooth_muscle_cells:vascular: 0.23, Osteoblasts:BMP2: 0.23
NB05_GTATCTTCACGCGAAA-1 Fibroblasts:breast 0.15 260.66
Raw ScoresiPS_cells:CRL2097_foreskin: 0.28, Smooth_muscle_cells:bronchial: 0.27, Fibroblasts:breast: 0.27, MSC: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, iPS_cells:adipose_stem_cells: 0.26, Smooth_muscle_cells:vascular: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:foreskin_fibrobasts: 0.26, Chondrocytes:MSC-derived: 0.26
NB05_TCATTTGGTTCTCATT-1 Neurons:adrenal_medulla_cell_line 0.10 257.25
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.17, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:adrenal_medulla_cell_line: 0.16, Endothelial_cells:lymphatic:TNFa_48h: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Endothelial_cells:HUVEC: 0.16, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.16, Endothelial_cells:lymphatic: 0.16, Endothelial_cells:HUVEC:H5N1-infected: 0.15
NB02_CTCTGGTCATAGTAAG-1 Endothelial_cells:lymphatic 0.11 249.27
Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.19, Smooth_muscle_cells:vascular: 0.19, Endothelial_cells:lymphatic: 0.19, Fibroblasts:breast: 0.19, Endothelial_cells:lymphatic:TNFa_48h: 0.18, Osteoblasts: 0.18, Endothelial_cells:HUVEC: 0.18, iPS_cells:adipose_stem_cells: 0.18, iPS_cells:CRL2097_foreskin: 0.18, Tissue_stem_cells:BM_MSC: 0.18
NB09_AAGGCAGTCTTCATGT-1 Neurons:adrenal_medulla_cell_line 0.08 239.25
Raw ScoresAstrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, Endothelial_cells:HUVEC:VEGF: 0.21, iPS_cells:CRL2097_foreskin: 0.21, Endothelial_cells:lymphatic: 0.21, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.2, Endothelial_cells:lymphatic:TNFa_48h: 0.2, Endothelial_cells:HUVEC: 0.2
NB12_GAAGCAGAGCTTATCG-1 Endothelial_cells:lymphatic:TNFa_48h 0.11 236.05
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.25, Endothelial_cells:lymphatic: 0.24, Endothelial_cells:lymphatic:TNFa_48h: 0.24, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.24, Endothelial_cells:HUVEC: 0.24, Endothelial_cells:HUVEC:IL-1b: 0.23, Endothelial_cells:blood_vessel: 0.23, Endothelial_cells:HUVEC:B._anthracis_LT: 0.23, Endothelial_cells:lymphatic:KSHV: 0.23, Endothelial_cells:HUVEC:H5N1-infected: 0.22
NB07_GTGAAGGCACGCTTTC-1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.04 224.51
Raw ScoresEndothelial_cells:HUVEC:IL-1b: 0.14, Endothelial_cells:lymphatic:TNFa_48h: 0.14, Endothelial_cells:lymphatic: 0.14, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.14, Endothelial_cells:HUVEC:VEGF: 0.14, Endothelial_cells:HUVEC: 0.13, Endothelial_cells:HUVEC:H5N1-infected: 0.13, Endothelial_cells:HUVEC:B._anthracis_LT: 0.13, Endothelial_cells:blood_vessel: 0.13, Endothelial_cells:lymphatic:KSHV: 0.13
NB11_CTAACTTCAGATCGGA-1 Endothelial_cells:lymphatic:KSHV 0.14 216.55
Raw ScoresEndothelial_cells:lymphatic:KSHV: 0.21, Endothelial_cells:lymphatic: 0.21, Endothelial_cells:lymphatic:TNFa_48h: 0.21, Endothelial_cells:blood_vessel: 0.2, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.2, Endothelial_cells:HUVEC:VEGF: 0.19, Endothelial_cells:HUVEC: 0.19, Endothelial_cells:HUVEC:IL-1b: 0.19, Endothelial_cells:HUVEC:B._anthracis_LT: 0.18, Endothelial_cells:HUVEC:H5N1-infected: 0.18
NB13_CTGTTTAAGTTGTCGT-1 Neurons:adrenal_medulla_cell_line 0.10 189.60
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, Endothelial_cells:HUVEC:VEGF: 0.19, Endothelial_cells:lymphatic:TNFa_48h: 0.19, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.19, Endothelial_cells:lymphatic: 0.19, Neuroepithelial_cell:ESC-derived: 0.19, Endothelial_cells:HUVEC: 0.19, Endothelial_cells:HUVEC:B._anthracis_LT: 0.18
NB11_AGTTGGTTCGCTTAGA-1 Endothelial_cells:lymphatic 0.12 189.24
Raw ScoresEndothelial_cells:lymphatic: 0.2, Endothelial_cells:lymphatic:TNFa_48h: 0.2, Endothelial_cells:HUVEC:VEGF: 0.19, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.19, Endothelial_cells:HUVEC: 0.19, Endothelial_cells:blood_vessel: 0.18, Endothelial_cells:lymphatic:KSHV: 0.18, Endothelial_cells:HUVEC:IL-1b: 0.18, Endothelial_cells:HUVEC:B._anthracis_LT: 0.18, Endothelial_cells:HUVEC:H5N1-infected: 0.17
NB08_GATGCTATCAGTGCAT-1 Neurons:adrenal_medulla_cell_line 0.12 188.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Endothelial_cells:HUVEC:VEGF: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Endothelial_cells:lymphatic:TNFa_48h: 0.16, Endothelial_cells:HUVEC: 0.16, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.16, Endothelial_cells:lymphatic: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Endothelial_cells:HUVEC:FPV-infected: 0.16
NB02_CAGGTGCAGACACGAC-1 Endothelial_cells:lymphatic:TNFa_48h 0.09 188.19
Raw ScoresEndothelial_cells:lymphatic: 0.17, Endothelial_cells:lymphatic:TNFa_48h: 0.16, Endothelial_cells:blood_vessel: 0.16, Endothelial_cells:HUVEC: 0.15, Endothelial_cells:lymphatic:KSHV: 0.15, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.15, Endothelial_cells:HUVEC:VEGF: 0.15, Endothelial_cells:HUVEC:IL-1b: 0.14, Endothelial_cells:HUVEC:B._anthracis_LT: 0.14, Smooth_muscle_cells:vascular: 0.13
NB12_AGATTGCTCCGCGTTT-1 Smooth_muscle_cells:vascular 0.09 186.30
Raw ScoresFibroblasts:breast: 0.19, iPS_cells:adipose_stem_cells: 0.18, Smooth_muscle_cells:bronchial: 0.18, Osteoblasts: 0.18, iPS_cells:CRL2097_foreskin: 0.18, Smooth_muscle_cells:bronchial:vit_D: 0.18, Smooth_muscle_cells:vascular: 0.18, Tissue_stem_cells:BM_MSC:BMP2: 0.18, Tissue_stem_cells:iliac_MSC: 0.18, Osteoblasts:BMP2: 0.18
NB02_TGACTAGAGCGTAATA-1 Fibroblasts:breast 0.17 181.79
Raw ScoresFibroblasts:breast: 0.25, Smooth_muscle_cells:vascular: 0.25, Smooth_muscle_cells:vascular:IL-17: 0.25, iPS_cells:adipose_stem_cells: 0.24, Osteoblasts: 0.24, Chondrocytes:MSC-derived: 0.24, Tissue_stem_cells:BM_MSC:TGFb3: 0.23, Tissue_stem_cells:BM_MSC: 0.23, Osteoblasts:BMP2: 0.23, iPS_cells:CRL2097_foreskin: 0.23
NB12_CGATGGCAGGCATGTG-1 Neurons:adrenal_medulla_cell_line 0.10 181.24
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.21, Endothelial_cells:lymphatic:KSHV: 0.2, Endothelial_cells:HUVEC:VEGF: 0.2, Endothelial_cells:lymphatic: 0.2, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.2, Endothelial_cells:HUVEC: 0.2, Endothelial_cells:blood_vessel: 0.19, Neurons:adrenal_medulla_cell_line: 0.19, Endothelial_cells:HUVEC:IL-1b: 0.19, Endothelial_cells:HUVEC:B._anthracis_LT: 0.19
NB14_CTACACCTCCAGTATG-1 Endothelial_cells:lymphatic:KSHV 0.10 180.18
Raw ScoresEndothelial_cells:lymphatic:KSHV: 0.19, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.18, Endothelial_cells:blood_vessel: 0.18, Endothelial_cells:lymphatic: 0.18, Endothelial_cells:lymphatic:TNFa_48h: 0.17, Endothelial_cells:HUVEC:VEGF: 0.17, Endothelial_cells:HUVEC: 0.17, Endothelial_cells:HUVEC:IL-1b: 0.17, Endothelial_cells:HUVEC:B._anthracis_LT: 0.17, Endothelial_cells:HUVEC:H5N1-infected: 0.16
NB02_CACACCTAGGCTCATT-1 Tissue_stem_cells:BM_MSC:TGFb3 0.10 164.15
Raw ScoresSmooth_muscle_cells:vascular:IL-17: 0.16, Tissue_stem_cells:BM_MSC:TGFb3: 0.16, iPS_cells:CRL2097_foreskin: 0.16, Smooth_muscle_cells:vascular: 0.15, Tissue_stem_cells:iliac_MSC: 0.15, Osteoblasts:BMP2: 0.15, Osteoblasts: 0.15, Tissue_stem_cells:BM_MSC:BMP2: 0.15, Smooth_muscle_cells:bronchial: 0.15, Chondrocytes:MSC-derived: 0.15
NB11_ATTGGTGAGGCACATG-1 Tissue_stem_cells:BM_MSC 0.11 161.47
Raw ScoresiPS_cells:CRL2097_foreskin: 0.21, iPS_cells:adipose_stem_cells: 0.21, Osteoblasts: 0.2, Osteoblasts:BMP2: 0.2, Fibroblasts:breast: 0.2, MSC: 0.2, Smooth_muscle_cells:bronchial: 0.19, Tissue_stem_cells:BM_MSC: 0.19, Tissue_stem_cells:BM_MSC:TGFb3: 0.19, Chondrocytes:MSC-derived: 0.19
NB12_GCGCCAATCCACGACG-1 Endothelial_cells:lymphatic 0.13 159.57
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.2, Endothelial_cells:lymphatic: 0.2, Endothelial_cells:HUVEC:VEGF: 0.19, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.18, Endothelial_cells:HUVEC: 0.17, Endothelial_cells:HUVEC:B._anthracis_LT: 0.17, Endothelial_cells:HUVEC:IL-1b: 0.17, Endothelial_cells:HUVEC:FPV-infected: 0.16, Endothelial_cells:HUVEC:H5N1-infected: 0.16, Endothelial_cells:blood_vessel: 0.16
NB02_ACGGAGAGTTGGGACA-1 Endothelial_cells:HUVEC:IL-1b 0.07 154.67
Raw ScoresEndothelial_cells:HUVEC:IL-1b: 0.13, Endothelial_cells:HUVEC: 0.13, Endothelial_cells:HUVEC:VEGF: 0.12, Endothelial_cells:lymphatic: 0.12, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.12, Endothelial_cells:blood_vessel: 0.12, Endothelial_cells:lymphatic:TNFa_48h: 0.12, Endothelial_cells:lymphatic:KSHV: 0.12, Endothelial_cells:HUVEC:B._anthracis_LT: 0.11, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.11
NB04_CGCCAAGGTGGCAAAC-1 Endothelial_cells:HUVEC:VEGF 0.11 150.56
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.17, Endothelial_cells:HUVEC: 0.16, Endothelial_cells:lymphatic: 0.16, Endothelial_cells:lymphatic:TNFa_48h: 0.15, Endothelial_cells:blood_vessel: 0.15, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.15, Smooth_muscle_cells:vascular:IL-17: 0.15, Neuroepithelial_cell:ESC-derived: 0.15, Endothelial_cells:lymphatic:KSHV: 0.15, Smooth_muscle_cells:vascular: 0.15
NB11_TGAAAGATCCGCAAGC-1 Endothelial_cells:blood_vessel 0.10 150.15
Raw ScoresEndothelial_cells:lymphatic:KSHV: 0.18, Endothelial_cells:blood_vessel: 0.18, Endothelial_cells:lymphatic:TNFa_48h: 0.18, Endothelial_cells:lymphatic: 0.17, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.17, Endothelial_cells:HUVEC: 0.16, Endothelial_cells:HUVEC:VEGF: 0.16, Endothelial_cells:HUVEC:IL-1b: 0.16, Endothelial_cells:HUVEC:B._anthracis_LT: 0.16, Endothelial_cells:HUVEC:FPV-infected: 0.15
NB05_ACGCCAGGTTGGTTTG-1 Endothelial_cells:lymphatic:TNFa_48h 0.10 145.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.17, Endothelial_cells:lymphatic: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Endothelial_cells:HUVEC:VEGF: 0.17, Neuroepithelial_cell:ESC-derived: 0.16, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.16, Neurons:adrenal_medulla_cell_line: 0.16, Endothelial_cells:HUVEC: 0.16, Endothelial_cells:HUVEC:IL-1b: 0.15, Endothelial_cells:HUVEC:B._anthracis_LT: 0.15
NB11_CGGACACTCCGCGCAA-1 Endothelial_cells:HUVEC:IFNg 0.12 144.52
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.19, Endothelial_cells:HUVEC: 0.19, Endothelial_cells:lymphatic: 0.19, Endothelial_cells:HUVEC:IFNg: 0.19, Endothelial_cells:lymphatic:TNFa_48h: 0.19, Endothelial_cells:HUVEC:H5N1-infected: 0.19, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.19, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.18, Endothelial_cells:blood_vessel: 0.18, Endothelial_cells:HUVEC:B._anthracis_LT: 0.18
NB05_TGCGTGGCAGACAAAT-1 Neurons:adrenal_medulla_cell_line 0.15 143.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.32, Endothelial_cells:HUVEC:VEGF: 0.3, Endothelial_cells:lymphatic:TNFa_48h: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.3, Endothelial_cells:lymphatic: 0.3, Endothelial_cells:HUVEC: 0.29, MSC: 0.29, iPS_cells:CRL2097_foreskin: 0.29
NB11_TAGGCATTCAGAGCTT-1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.08 142.30
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.19, Endothelial_cells:HUVEC: 0.19, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.19, Endothelial_cells:HUVEC:H5N1-infected: 0.18, Endothelial_cells:HUVEC:FPV-infected: 0.18, Endothelial_cells:HUVEC:IFNg: 0.18, Endothelial_cells:blood_vessel: 0.18, Endothelial_cells:lymphatic:TNFa_48h: 0.18, Endothelial_cells:HUVEC:B._anthracis_LT: 0.18, Endothelial_cells:lymphatic: 0.18
NB14_ACGAGGAGTCACTGGC-1 Tissue_stem_cells:BM_MSC 0.09 140.54
Raw ScoresChondrocytes:MSC-derived: 0.21, Osteoblasts: 0.21, Endothelial_cells:lymphatic:KSHV: 0.21, iPS_cells:adipose_stem_cells: 0.21, Fibroblasts:breast: 0.21, iPS_cells:CRL2097_foreskin: 0.21, Tissue_stem_cells:BM_MSC:TGFb3: 0.2, Smooth_muscle_cells:bronchial: 0.2, Tissue_stem_cells:BM_MSC:BMP2: 0.2, Neurons:Schwann_cell: 0.2
NB08_CATCCACCAATAGCGG-1 Endothelial_cells:HUVEC:VEGF 0.09 139.91
Raw ScoresEndothelial_cells:HUVEC:VEGF: 0.16, Endothelial_cells:lymphatic: 0.15, Endothelial_cells:lymphatic:TNFa_48h: 0.15, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.15, Endothelial_cells:HUVEC: 0.14, Endothelial_cells:HUVEC:H5N1-infected: 0.14, Endothelial_cells:HUVEC:IFNg: 0.14, Endothelial_cells:HUVEC:IL-1b: 0.14, Endothelial_cells:HUVEC:PR8-infected: 0.14, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.13
NB14_TTTCCTCTCAGTTTGG-1 Endothelial_cells:lymphatic:KSHV 0.09 138.63
Raw ScoresEndothelial_cells:HUVEC:Serum_Amyloid_A: 0.14, Endothelial_cells:lymphatic:KSHV: 0.14, Endothelial_cells:lymphatic: 0.14, Endothelial_cells:HUVEC:VEGF: 0.14, Endothelial_cells:lymphatic:TNFa_48h: 0.14, Endothelial_cells:blood_vessel: 0.14, Endothelial_cells:HUVEC: 0.14, Endothelial_cells:HUVEC:IL-1b: 0.14, Endothelial_cells:HUVEC:B._anthracis_LT: 0.13, Endothelial_cells:HUVEC:FPV-infected: 0.13
NB14_AATCCAGCATCGGTTA-1 Endothelial_cells:blood_vessel 0.10 135.99
Raw ScoresEndothelial_cells:blood_vessel: 0.14, Endothelial_cells:lymphatic: 0.14, Endothelial_cells:lymphatic:KSHV: 0.14, Endothelial_cells:lymphatic:TNFa_48h: 0.14, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.13, Endothelial_cells:HUVEC:VEGF: 0.13, Endothelial_cells:HUVEC: 0.12, Endothelial_cells:HUVEC:IL-1b: 0.12, Endothelial_cells:HUVEC:B._anthracis_LT: 0.12, Neurons:adrenal_medulla_cell_line: 0.12
NB02_GGAACTTCACGGTAGA-1 Endothelial_cells:HUVEC:VEGF 0.10 132.78
Raw ScoresEndothelial_cells:lymphatic: 0.14, Endothelial_cells:lymphatic:TNFa_48h: 0.13, Endothelial_cells:HUVEC:VEGF: 0.13, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.12, Endothelial_cells:HUVEC: 0.12, Endothelial_cells:lymphatic:KSHV: 0.12, Endothelial_cells:blood_vessel: 0.12, Endothelial_cells:HUVEC:IL-1b: 0.11, Endothelial_cells:HUVEC:IFNg: 0.11, Endothelial_cells:HUVEC:FPV-infected: 0.11
NB03_ATCGAGTAGATGCGAC-1 Endothelial_cells:lymphatic 0.12 129.47
Raw ScoresEndothelial_cells:lymphatic: 0.18, Endothelial_cells:lymphatic:TNFa_48h: 0.18, Endothelial_cells:lymphatic:KSHV: 0.17, Endothelial_cells:HUVEC:VEGF: 0.17, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.17, Endothelial_cells:blood_vessel: 0.17, Endothelial_cells:HUVEC: 0.16, Endothelial_cells:HUVEC:IL-1b: 0.15, Endothelial_cells:HUVEC:B._anthracis_LT: 0.15, Endothelial_cells:HUVEC:FPV-infected: 0.15


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.21e-08
Mean rank of genes in gene set: 1969.55
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MECOM 0.0201301 2 GTEx DepMap Descartes 1.55 435.78
HES1 0.0074138 23 GTEx DepMap Descartes 0.35 572.55
TM4SF1 0.0073164 26 GTEx DepMap Descartes 0.37 273.32
IGFBP3 0.0047601 63 GTEx DepMap Descartes 0.42 166.79
SPRY1 0.0036791 110 GTEx DepMap Descartes 0.30 210.51
JAG1 0.0034435 121 GTEx DepMap Descartes 0.41 114.73
GJA1 0.0032349 133 GTEx DepMap Descartes 0.20 86.13
ADAMTS1 0.0032341 134 GTEx DepMap Descartes 0.21 77.11
THBD 0.0020309 257 GTEx DepMap Descartes 0.13 60.83
DUSP6 0.0016678 321 GTEx DepMap Descartes 0.36 186.62
CLIC4 0.0014635 371 GTEx DepMap Descartes 0.56 206.52
RHOB 0.0009838 590 GTEx DepMap Descartes 0.25 159.47
SHROOM2 0.0009564 611 GTEx DepMap Descartes 0.11 25.55
IVNS1ABP 0.0007308 798 GTEx DepMap Descartes 0.38 169.84
FBLN2 0.0006150 933 GTEx DepMap Descartes 0.10 43.83
MCF2L 0.0002489 2033 GTEx DepMap Descartes 0.38 118.14
LFNG 0.0000624 4148 GTEx DepMap Descartes 0.06 46.85
FAM102A -0.0000209 5945 GTEx DepMap Descartes 0.08 21.56
CDK1 -0.0002158 10970 GTEx DepMap Descartes 0.06 32.03
MARCKSL1 -0.0003128 11802 GTEx DepMap Descartes 0.48 296.08


PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.75e-04
Mean rank of genes in gene set: 3147.88
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD36 0.0024791 191 GTEx DepMap Descartes 0.56 162.25
PTGS2 0.0012883 433 GTEx DepMap Descartes 0.09 40.76
TGFB1 0.0009255 640 GTEx DepMap Descartes 0.37 219.99
STAT3 0.0007766 752 GTEx DepMap Descartes 0.67 198.99
ANXA1 0.0007747 754 GTEx DepMap Descartes 0.44 569.54
TNFRSF10B 0.0007447 788 GTEx DepMap Descartes 0.23 112.53
CSF1 0.0007313 797 GTEx DepMap Descartes 0.04 25.23
HIF1A 0.0007047 827 GTEx DepMap Descartes 0.85 367.75
STAT1 0.0004968 1143 GTEx DepMap Descartes 0.33 108.55
STAT6 0.0004486 1249 GTEx DepMap Descartes 0.15 65.93
IRF1 0.0003793 1445 GTEx DepMap Descartes 0.08 35.29
IL1B 0.0000157 5063 GTEx DepMap Descartes 0.00 0.00
ARG2 -0.0000121 5725 GTEx DepMap Descartes 0.11 73.46
SLC27A2 -0.0000887 8073 GTEx DepMap Descartes 0.02 18.79
CD84 -0.0001948 10646 GTEx DepMap Descartes 0.02 1.48
ARG1 -0.0003217 11840 GTEx DepMap Descartes 0.00 0.00


Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.73e-04
Mean rank of genes in gene set: 168.25
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FLT1 0.0209947 1 GTEx DepMap Descartes 2.24 411.49
EGFL7 0.0126636 5 GTEx DepMap Descartes 1.82 2292.23
KDR 0.0058169 42 GTEx DepMap Descartes 0.25 75.48
PRCP 0.0009429 625 GTEx DepMap Descartes 0.28 51.02




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9819.58
Median rank of genes in gene set: 11104
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GRB10 0.0061558 36 GTEx DepMap Descartes 1.10 401.29
ABLIM1 0.0015183 353 GTEx DepMap Descartes 0.45 93.29
RPS6KA2 0.0012092 462 GTEx DepMap Descartes 0.58 150.29
LYN 0.0008816 668 GTEx DepMap Descartes 0.24 64.17
CD200 0.0005189 1099 GTEx DepMap Descartes 0.38 257.99
NFIL3 0.0005034 1127 GTEx DepMap Descartes 0.03 35.18
CXCR4 0.0004615 1218 GTEx DepMap Descartes 0.18 99.37
THSD7A 0.0004411 1266 GTEx DepMap Descartes 1.74 249.09
AKAP12 0.0003716 1468 GTEx DepMap Descartes 0.50 110.07
ST3GAL6 0.0003409 1600 GTEx DepMap Descartes 0.39 193.97
CDC42EP3 0.0002497 2029 GTEx DepMap Descartes 0.16 42.19
TACC2 0.0002426 2069 GTEx DepMap Descartes 0.30 44.23
FAM107B 0.0002117 2301 GTEx DepMap Descartes 0.20 71.40
MYRIP 0.0002117 2302 GTEx DepMap Descartes 0.26 92.98
PIK3R1 0.0002101 2319 GTEx DepMap Descartes 0.43 84.37
DPYSL3 0.0002062 2345 GTEx DepMap Descartes 0.88 223.98
GNB1 0.0001968 2425 GTEx DepMap Descartes 0.83 342.30
MYO5A 0.0001934 2453 GTEx DepMap Descartes 0.39 46.50
LMO3 0.0001912 2475 GTEx DepMap Descartes 0.01 5.15
HEY1 0.0001610 2767 GTEx DepMap Descartes 0.03 32.33
POLB 0.0001352 3035 GTEx DepMap Descartes 0.10 102.56
TDG 0.0001089 3381 GTEx DepMap Descartes 0.21 87.68
KIF15 0.0000831 3749 GTEx DepMap Descartes 0.09 18.08
PDK1 0.0000769 3865 GTEx DepMap Descartes 0.07 3.81
KLF13 0.0000715 3982 GTEx DepMap Descartes 0.20 39.23
ANKRD46 0.0000685 4033 GTEx DepMap Descartes 0.09 35.99
GMNN 0.0000570 4252 GTEx DepMap Descartes 0.04 54.02
ARHGEF7 0.0000499 4367 GTEx DepMap Descartes 0.45 113.60
MAPK8 0.0000486 4391 GTEx DepMap Descartes 0.56 120.03
NAPB 0.0000447 4477 GTEx DepMap Descartes 0.11 44.29


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.75e-46
Mean rank of genes in gene set: 3840.16
Median rank of genes in gene set: 2410
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
WWTR1 0.0104003 10 GTEx DepMap Descartes 1.91 657.44
EMP1 0.0081823 20 GTEx DepMap Descartes 1.27 576.00
HES1 0.0074138 23 GTEx DepMap Descartes 0.35 572.55
RHOJ 0.0073426 24 GTEx DepMap Descartes 0.63 362.46
TM4SF1 0.0073164 26 GTEx DepMap Descartes 0.37 273.32
COL4A1 0.0066876 33 GTEx DepMap Descartes 1.75 503.70
ID1 0.0059744 38 GTEx DepMap Descartes 0.46 835.54
TGFBR2 0.0059431 39 GTEx DepMap Descartes 0.74 205.94
COL4A2 0.0058635 40 GTEx DepMap Descartes 1.62 447.64
PTPRG 0.0055071 47 GTEx DepMap Descartes 2.52 458.56
PTPN14 0.0051763 52 GTEx DepMap Descartes 0.45 58.88
ADAMTS5 0.0048485 58 GTEx DepMap Descartes 0.26 51.11
ETS1 0.0045344 71 GTEx DepMap Descartes 0.64 230.70
TFPI 0.0045312 72 GTEx DepMap Descartes 0.91 190.75
SASH1 0.0040449 94 GTEx DepMap Descartes 0.75 209.84
FNDC3B 0.0038348 104 GTEx DepMap Descartes 1.68 384.59
FLRT2 0.0037529 107 GTEx DepMap Descartes 1.13 62.68
SPRY1 0.0036791 110 GTEx DepMap Descartes 0.30 210.51
NFIA 0.0036717 111 GTEx DepMap Descartes 1.21 46.64
RIN2 0.0036207 114 GTEx DepMap Descartes 0.55 207.49
ELK3 0.0035877 116 GTEx DepMap Descartes 0.42 195.15
NRP1 0.0033220 125 GTEx DepMap Descartes 1.75 462.96
A2M 0.0033209 126 GTEx DepMap Descartes 0.74 273.79
PDLIM1 0.0032865 128 GTEx DepMap Descartes 0.26 268.40
GJA1 0.0032349 133 GTEx DepMap Descartes 0.20 86.13
PEAK1 0.0028837 156 GTEx DepMap Descartes 1.07 NA
PLSCR4 0.0028565 157 GTEx DepMap Descartes 0.28 138.54
MAML2 0.0027883 164 GTEx DepMap Descartes 1.74 415.56
PDE7B 0.0027336 168 GTEx DepMap Descartes 0.61 192.28
NID1 0.0026962 173 GTEx DepMap Descartes 0.30 99.19


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.83e-01
Mean rank of genes in gene set: 7547.61
Median rank of genes in gene set: 8769.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SH3PXD2B 0.0014302 382 GTEx DepMap Descartes 0.39 73.03
SH3BP5 0.0013620 406 GTEx DepMap Descartes 0.29 117.41
LDLR 0.0004465 1253 GTEx DepMap Descartes 0.17 55.33
PAPSS2 0.0004292 1290 GTEx DepMap Descartes 0.18 67.90
BAIAP2L1 0.0003141 1719 GTEx DepMap Descartes 0.07 31.97
PDE10A 0.0002698 1915 GTEx DepMap Descartes 0.80 184.36
FDPS 0.0001626 2752 GTEx DepMap Descartes 0.37 240.95
ERN1 0.0001041 3452 GTEx DepMap Descartes 0.13 21.36
CYB5B 0.0000999 3496 GTEx DepMap Descartes 0.21 76.01
NPC1 0.0000931 3606 GTEx DepMap Descartes 0.18 49.46
GRAMD1B 0.0000805 3801 GTEx DepMap Descartes 0.09 26.43
FDX1 0.0000102 5180 GTEx DepMap Descartes 0.04 16.57
DHCR7 -0.0000311 6250 GTEx DepMap Descartes 0.02 6.62
STAR -0.0000755 7655 GTEx DepMap Descartes 0.00 0.00
SCAP -0.0000855 7966 GTEx DepMap Descartes 0.20 65.72
INHA -0.0001017 8457 GTEx DepMap Descartes 0.01 1.39
SCARB1 -0.0001100 8680 GTEx DepMap Descartes 0.12 22.58
IGF1R -0.0001110 8707 GTEx DepMap Descartes 0.90 98.25
FDXR -0.0001150 8832 GTEx DepMap Descartes 0.04 41.22
FREM2 -0.0001189 8943 GTEx DepMap Descartes 0.01 0.30
CLU -0.0001394 9510 GTEx DepMap Descartes 0.47 249.17
GSTA4 -0.0001480 9725 GTEx DepMap Descartes 0.13 116.78
MSMO1 -0.0001657 10102 GTEx DepMap Descartes 0.03 9.19
SGCZ -0.0001675 10138 GTEx DepMap Descartes 0.18 23.86
HMGCR -0.0001761 10317 GTEx DepMap Descartes 0.10 28.93
DHCR24 -0.0001819 10429 GTEx DepMap Descartes 0.07 31.45
POR -0.0001834 10454 GTEx DepMap Descartes 0.11 52.96
TM7SF2 -0.0002023 10774 GTEx DepMap Descartes 0.06 26.85
PEG3 -0.0002189 11013 GTEx DepMap Descartes 0.12 NA
HMGCS1 -0.0002406 11261 GTEx DepMap Descartes 0.06 22.97


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11930.49
Median rank of genes in gene set: 12258
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RPH3A -0.0000626 7238 GTEx DepMap Descartes 0.03 10.25
MAB21L1 -0.0001123 8756 GTEx DepMap Descartes 0.10 61.17
MAB21L2 -0.0002237 11070 GTEx DepMap Descartes 0.09 43.02
REEP1 -0.0002273 11120 GTEx DepMap Descartes 0.17 34.19
CNTFR -0.0002273 11121 GTEx DepMap Descartes 0.11 38.36
GAL -0.0002614 11465 GTEx DepMap Descartes 0.33 844.13
RGMB -0.0002726 11564 GTEx DepMap Descartes 0.15 34.19
NTRK1 -0.0002812 11621 GTEx DepMap Descartes 0.17 47.61
PTCHD1 -0.0002917 11687 GTEx DepMap Descartes 0.09 4.23
GAP43 -0.0003152 11815 GTEx DepMap Descartes 0.45 204.49
TMEFF2 -0.0003210 11835 GTEx DepMap Descartes 0.17 45.76
HS3ST5 -0.0003467 11951 GTEx DepMap Descartes 0.52 118.83
FAT3 -0.0003471 11954 GTEx DepMap Descartes 0.19 11.58
GREM1 -0.0003539 11970 GTEx DepMap Descartes 0.04 6.24
CNKSR2 -0.0003621 12013 GTEx DepMap Descartes 0.32 33.94
PLXNA4 -0.0003798 12058 GTEx DepMap Descartes 0.41 24.45
TUBB2A -0.0003870 12084 GTEx DepMap Descartes 0.31 204.12
ANKFN1 -0.0003881 12092 GTEx DepMap Descartes 0.23 29.93
SYNPO2 -0.0004503 12223 GTEx DepMap Descartes 0.40 22.80
SLC44A5 -0.0004517 12225 GTEx DepMap Descartes 0.48 68.28
EPHA6 -0.0004730 12258 GTEx DepMap Descartes 0.32 58.10
SLC6A2 -0.0004785 12271 GTEx DepMap Descartes 0.12 43.80
MLLT11 -0.0005030 12314 GTEx DepMap Descartes 0.34 163.39
EYA1 -0.0005397 12356 GTEx DepMap Descartes 0.28 69.98
CCND1 -0.0005797 12382 GTEx DepMap Descartes 0.96 248.18
ISL1 -0.0006045 12401 GTEx DepMap Descartes 0.33 133.29
ELAVL2 -0.0006568 12429 GTEx DepMap Descartes 0.28 50.99
IL7 -0.0006597 12431 GTEx DepMap Descartes 0.96 414.27
EYA4 -0.0007031 12458 GTEx DepMap Descartes 0.42 86.08
TMEM132C -0.0007137 12464 GTEx DepMap Descartes 1.17 197.99


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.45e-19
Mean rank of genes in gene set: 1107.29
Median rank of genes in gene set: 136
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CALCRL 0.0103714 11 GTEx DepMap Descartes 1.17 398.05
ESM1 0.0086103 18 GTEx DepMap Descartes 0.16 65.80
NOTCH4 0.0073226 25 GTEx DepMap Descartes 0.56 132.54
PLVAP 0.0072142 27 GTEx DepMap Descartes 0.55 375.10
ID1 0.0059744 38 GTEx DepMap Descartes 0.46 835.54
CDH5 0.0058189 41 GTEx DepMap Descartes 0.28 129.83
KDR 0.0058169 42 GTEx DepMap Descartes 0.25 75.48
BTNL9 0.0054856 48 GTEx DepMap Descartes 0.10 38.47
CDH13 0.0050476 54 GTEx DepMap Descartes 1.37 299.98
SLCO2A1 0.0049131 57 GTEx DepMap Descartes 0.45 185.90
FLT4 0.0047986 60 GTEx DepMap Descartes 0.20 94.84
PTPRB 0.0047065 65 GTEx DepMap Descartes 0.96 137.73
TIE1 0.0046093 68 GTEx DepMap Descartes 0.33 150.27
ROBO4 0.0039215 102 GTEx DepMap Descartes 0.17 58.30
SHANK3 0.0037920 106 GTEx DepMap Descartes 0.45 126.71
ARHGAP29 0.0037192 109 GTEx DepMap Descartes 0.87 195.12
RASIP1 0.0036707 112 GTEx DepMap Descartes 0.15 96.00
KANK3 0.0035841 117 GTEx DepMap Descartes 0.26 246.01
CLDN5 0.0034482 120 GTEx DepMap Descartes 0.29 143.19
PODXL 0.0029192 152 GTEx DepMap Descartes 0.47 140.80
TEK 0.0028196 160 GTEx DepMap Descartes 0.21 91.19
SHE 0.0027145 172 GTEx DepMap Descartes 0.15 45.77
NR5A2 0.0026708 175 GTEx DepMap Descartes 0.25 109.20
MMRN2 0.0026142 179 GTEx DepMap Descartes 0.16 62.51
EFNB2 0.0020892 249 GTEx DepMap Descartes 0.50 127.06
NPR1 0.0017071 312 GTEx DepMap Descartes 0.05 22.81
HYAL2 0.0011449 489 GTEx DepMap Descartes 0.15 78.29
CEACAM1 0.0006118 941 GTEx DepMap Descartes 0.16 91.83
RAMP2 0.0005715 1016 GTEx DepMap Descartes 0.17 370.40
F8 0.0005712 1017 GTEx DepMap Descartes 0.04 3.52


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8155.75
Median rank of genes in gene set: 10032
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IGFBP3 0.0047601 63 GTEx DepMap Descartes 0.42 166.79
DKK2 0.0016990 314 GTEx DepMap Descartes 0.07 23.63
MGP 0.0014700 369 GTEx DepMap Descartes 0.74 597.18
EDNRA 0.0009869 586 GTEx DepMap Descartes 0.13 29.36
ELN 0.0008618 685 GTEx DepMap Descartes 0.40 182.06
RSPO3 0.0008002 734 GTEx DepMap Descartes 0.01 NA
COL27A1 0.0006879 845 GTEx DepMap Descartes 0.13 28.84
ADAMTSL3 0.0005712 1018 GTEx DepMap Descartes 0.07 19.65
ABCC9 0.0003703 1472 GTEx DepMap Descartes 0.13 13.65
CD248 0.0001530 2841 GTEx DepMap Descartes 0.08 46.86
ACTA2 0.0000710 3991 GTEx DepMap Descartes 0.23 203.28
CLDN11 0.0000566 4258 GTEx DepMap Descartes 0.08 43.10
ABCA6 0.0000362 4648 GTEx DepMap Descartes 0.07 10.28
SFRP2 -0.0000503 6825 GTEx DepMap Descartes 0.02 26.04
PAMR1 -0.0000606 7161 GTEx DepMap Descartes 0.06 23.87
OGN -0.0000857 7971 GTEx DepMap Descartes 0.04 13.55
ITGA11 -0.0000923 8179 GTEx DepMap Descartes 0.09 12.05
PCDH18 -0.0001021 8469 GTEx DepMap Descartes 0.02 1.83
SCARA5 -0.0001134 8786 GTEx DepMap Descartes 0.00 0.00
LRRC17 -0.0001288 9230 GTEx DepMap Descartes 0.01 5.40
COL6A3 -0.0001428 9598 GTEx DepMap Descartes 0.39 43.67
LAMC3 -0.0001430 9603 GTEx DepMap Descartes 0.01 3.79
GLI2 -0.0001836 10461 GTEx DepMap Descartes 0.06 20.62
LOX -0.0001938 10630 GTEx DepMap Descartes 0.02 3.29
GAS2 -0.0002175 10997 GTEx DepMap Descartes 0.07 51.92
PRICKLE1 -0.0002289 11143 GTEx DepMap Descartes 0.31 70.70
PRRX1 -0.0002365 11218 GTEx DepMap Descartes 0.15 50.33
CCDC80 -0.0002388 11244 GTEx DepMap Descartes 0.14 24.73
ADAMTS2 -0.0003389 11920 GTEx DepMap Descartes 0.20 35.98
HHIP -0.0003446 11946 GTEx DepMap Descartes 0.08 5.79


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10790.21
Median rank of genes in gene set: 11864
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PENK 0.0001217 3205 GTEx DepMap Descartes 0.01 5.89
ARC 0.0000614 4169 GTEx DepMap Descartes 0.05 25.00
GCH1 0.0000056 5299 GTEx DepMap Descartes 0.19 95.66
SLC24A2 -0.0000255 6077 GTEx DepMap Descartes 0.06 7.59
LAMA3 -0.0000483 6768 GTEx DepMap Descartes 0.07 5.68
DGKK -0.0000831 7898 GTEx DepMap Descartes 0.02 3.35
SORCS3 -0.0000914 8149 GTEx DepMap Descartes 0.04 8.10
SLC35F3 -0.0001808 10409 GTEx DepMap Descartes 0.22 92.92
C1QL1 -0.0001966 10678 GTEx DepMap Descartes 0.07 78.45
CNTN3 -0.0002075 10851 GTEx DepMap Descartes 0.09 16.14
CDH12 -0.0002168 10986 GTEx DepMap Descartes 0.06 7.98
SLC18A1 -0.0002297 11149 GTEx DepMap Descartes 0.17 67.31
GRID2 -0.0002339 11201 GTEx DepMap Descartes 0.26 23.21
HTATSF1 -0.0002441 11301 GTEx DepMap Descartes 0.08 33.41
SPOCK3 -0.0002811 11619 GTEx DepMap Descartes 0.09 47.69
TENM1 -0.0002993 11738 GTEx DepMap Descartes 0.42 NA
KSR2 -0.0002997 11743 GTEx DepMap Descartes 0.18 7.83
TBX20 -0.0003097 11783 GTEx DepMap Descartes 0.09 42.63
PACRG -0.0003272 11863 GTEx DepMap Descartes 0.34 185.60
PCSK2 -0.0003273 11865 GTEx DepMap Descartes 0.17 31.25
AGBL4 -0.0003576 11990 GTEx DepMap Descartes 1.04 319.90
EML6 -0.0003638 12017 GTEx DepMap Descartes 0.21 39.97
ST18 -0.0003819 12067 GTEx DepMap Descartes 0.09 24.59
GRM7 -0.0003993 12129 GTEx DepMap Descartes 0.14 22.60
CDH18 -0.0004008 12133 GTEx DepMap Descartes 0.11 35.41
MGAT4C -0.0004023 12136 GTEx DepMap Descartes 0.37 11.88
NTNG1 -0.0004169 12175 GTEx DepMap Descartes 0.37 65.18
KCTD16 -0.0004972 12305 GTEx DepMap Descartes 0.61 40.16
GALNTL6 -0.0005141 12327 GTEx DepMap Descartes 0.18 32.25
FAM155A -0.0005277 12343 GTEx DepMap Descartes 5.12 742.73


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.59e-01
Mean rank of genes in gene set: 5604.62
Median rank of genes in gene set: 4843
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCH3 0.0014632 372 GTEx DepMap Descartes 0.55 NA
SLC25A37 0.0010449 543 GTEx DepMap Descartes 0.30 106.20
GYPC 0.0009551 615 GTEx DepMap Descartes 0.10 72.28
RAPGEF2 0.0008988 652 GTEx DepMap Descartes 0.85 150.38
SPECC1 0.0006167 930 GTEx DepMap Descartes 0.08 14.46
MICAL2 0.0006074 950 GTEx DepMap Descartes 0.31 97.03
TSPAN5 0.0003374 1615 GTEx DepMap Descartes 0.85 302.19
CPOX 0.0001705 2672 GTEx DepMap Descartes 0.07 37.99
RGS6 0.0000980 3524 GTEx DepMap Descartes 0.02 3.05
TMCC2 0.0000655 4085 GTEx DepMap Descartes 0.02 5.75
SNCA 0.0000511 4348 GTEx DepMap Descartes 0.19 59.79
DENND4A 0.0000488 4385 GTEx DepMap Descartes 0.61 95.49
CAT 0.0000468 4423 GTEx DepMap Descartes 0.10 59.93
ALAS2 0.0000277 4819 GTEx DepMap Descartes 0.00 0.00
RHD 0.0000265 4843 GTEx DepMap Descartes 0.06 26.16
SLC25A21 0.0000252 4867 GTEx DepMap Descartes 0.03 11.19
TRAK2 0.0000099 5192 GTEx DepMap Descartes 0.12 20.57
SELENBP1 -0.0000499 6818 GTEx DepMap Descartes 0.01 3.02
XPO7 -0.0000759 7664 GTEx DepMap Descartes 0.24 65.12
ABCB10 -0.0000767 7692 GTEx DepMap Descartes 0.11 29.16
SLC4A1 -0.0000827 7886 GTEx DepMap Descartes 0.00 0.00
SOX6 -0.0001160 8859 GTEx DepMap Descartes 0.34 31.65
FECH -0.0001174 8904 GTEx DepMap Descartes 0.07 7.94
SPTB -0.0001226 9057 GTEx DepMap Descartes 0.04 9.03
BLVRB -0.0001993 10716 GTEx DepMap Descartes 0.04 18.29
EPB41 -0.0002275 11124 GTEx DepMap Descartes 0.35 71.66
GCLC -0.0002689 11534 GTEx DepMap Descartes 0.10 52.73
ANK1 -0.0002920 11689 GTEx DepMap Descartes 0.13 17.05
TFR2 -0.0003021 11756 GTEx DepMap Descartes 0.13 31.02
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.48e-01
Mean rank of genes in gene set: 6666.71
Median rank of genes in gene set: 6410.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PTPRE 0.0056420 45 GTEx DepMap Descartes 1.10 409.02
SFMBT2 0.0022734 220 GTEx DepMap Descartes 0.80 163.84
ITPR2 0.0016423 327 GTEx DepMap Descartes 0.71 93.49
HRH1 0.0010938 512 GTEx DepMap Descartes 0.23 55.28
SLC9A9 0.0007982 735 GTEx DepMap Descartes 0.48 218.16
FGL2 0.0003456 1579 GTEx DepMap Descartes 0.02 3.71
MSR1 0.0001954 2437 GTEx DepMap Descartes 0.10 44.12
SLC1A3 0.0001858 2530 GTEx DepMap Descartes 0.05 26.68
WWP1 0.0001398 2975 GTEx DepMap Descartes 0.29 96.42
CTSC 0.0001298 3100 GTEx DepMap Descartes 0.08 27.20
ABCA1 0.0000708 3994 GTEx DepMap Descartes 0.23 30.73
MS4A4A 0.0000581 4240 GTEx DepMap Descartes 0.01 11.03
MERTK 0.0000334 4704 GTEx DepMap Descartes 0.12 34.62
LGMN -0.0000028 5481 GTEx DepMap Descartes 0.20 118.86
CD163 -0.0000107 5686 GTEx DepMap Descartes 0.02 4.26
HCK -0.0000115 5711 GTEx DepMap Descartes 0.05 35.65
RGL1 -0.0000117 5717 GTEx DepMap Descartes 0.25 58.45
CTSS -0.0000248 6052 GTEx DepMap Descartes 0.08 29.31
AXL -0.0000344 6330 GTEx DepMap Descartes 0.12 39.53
TGFBI -0.0000391 6491 GTEx DepMap Descartes 0.12 32.10
ADAP2 -0.0000508 6840 GTEx DepMap Descartes 0.10 39.21
CD74 -0.0000638 7275 GTEx DepMap Descartes 0.45 248.71
IFNGR1 -0.0000641 7287 GTEx DepMap Descartes 0.15 67.96
ATP8B4 -0.0000931 8197 GTEx DepMap Descartes 0.02 5.98
CPVL -0.0000978 8334 GTEx DepMap Descartes 0.09 62.79
FGD2 -0.0001272 9186 GTEx DepMap Descartes 0.03 6.31
RBPJ -0.0001521 9819 GTEx DepMap Descartes 0.35 85.10
CST3 -0.0001601 9988 GTEx DepMap Descartes 0.29 120.72
MARCH1 -0.0001680 10150 GTEx DepMap Descartes 0.18 NA
SLCO2B1 -0.0001924 10605 GTEx DepMap Descartes 0.09 33.18


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.57e-01
Mean rank of genes in gene set: 5726.02
Median rank of genes in gene set: 3896
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ADAMTS5 0.0048485 58 GTEx DepMap Descartes 0.26 51.11
STARD13 0.0025288 189 GTEx DepMap Descartes 0.58 151.50
LAMA4 0.0024704 192 GTEx DepMap Descartes 0.28 78.04
COL18A1 0.0024269 201 GTEx DepMap Descartes 1.01 278.75
EDNRB 0.0014604 374 GTEx DepMap Descartes 0.06 15.33
LAMC1 0.0014165 387 GTEx DepMap Descartes 0.57 131.14
NRXN3 0.0013205 422 GTEx DepMap Descartes 0.85 161.47
LAMB1 0.0012700 437 GTEx DepMap Descartes 0.78 244.45
VIM 0.0011772 474 GTEx DepMap Descartes 1.17 865.55
OLFML2A 0.0009323 632 GTEx DepMap Descartes 0.07 17.00
EGFLAM 0.0006692 869 GTEx DepMap Descartes 0.16 37.31
KCTD12 0.0005863 982 GTEx DepMap Descartes 0.10 21.91
PLCE1 0.0005330 1072 GTEx DepMap Descartes 0.12 8.65
HMGA2 0.0004458 1256 GTEx DepMap Descartes 0.02 2.82
PTPRZ1 0.0004214 1309 GTEx DepMap Descartes 0.00 0.00
GAS7 0.0004207 1310 GTEx DepMap Descartes 0.23 64.72
PLP1 0.0003552 1541 GTEx DepMap Descartes 0.00 0.00
IL1RAPL2 0.0003107 1734 GTEx DepMap Descartes 0.06 8.28
ERBB3 0.0001759 2617 GTEx DepMap Descartes 0.01 3.37
SLC35F1 0.0001758 2621 GTEx DepMap Descartes 0.09 18.93
TRPM3 0.0001069 3407 GTEx DepMap Descartes 0.26 16.26
MPZ 0.0000936 3597 GTEx DepMap Descartes 0.02 6.71
IL1RAPL1 0.0000604 4195 GTEx DepMap Descartes 0.17 73.44
XKR4 -0.0000326 6280 GTEx DepMap Descartes 0.31 13.46
COL5A2 -0.0000460 6694 GTEx DepMap Descartes 0.48 127.32
MDGA2 -0.0000826 7883 GTEx DepMap Descartes 0.00 0.00
GRIK3 -0.0000965 8305 GTEx DepMap Descartes 0.04 4.13
SOX5 -0.0001052 8550 GTEx DepMap Descartes 0.46 80.15
COL25A1 -0.0001417 9566 GTEx DepMap Descartes 0.01 2.50
SFRP1 -0.0001459 9666 GTEx DepMap Descartes 0.07 17.78


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.02e-05
Mean rank of genes in gene set: 4112.58
Median rank of genes in gene set: 1597
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MCTP1 0.0082794 19 GTEx DepMap Descartes 1.53 540.46
FLI1 0.0057673 43 GTEx DepMap Descartes 0.80 268.87
STOM 0.0031356 140 GTEx DepMap Descartes 0.39 189.38
MMRN1 0.0031061 142 GTEx DepMap Descartes 0.27 93.38
ARHGAP6 0.0026290 178 GTEx DepMap Descartes 0.24 90.69
SLC2A3 0.0025902 184 GTEx DepMap Descartes 0.60 308.57
LTBP1 0.0020979 248 GTEx DepMap Descartes 0.28 79.69
MYH9 0.0019614 272 GTEx DepMap Descartes 0.61 116.91
GSN 0.0014975 358 GTEx DepMap Descartes 0.53 166.80
LIMS1 0.0009330 631 GTEx DepMap Descartes 0.54 177.90
TGFB1 0.0009255 640 GTEx DepMap Descartes 0.37 219.99
TRPC6 0.0008505 694 GTEx DepMap Descartes 0.10 39.37
FLNA 0.0007639 767 GTEx DepMap Descartes 0.53 117.50
CD9 0.0007526 777 GTEx DepMap Descartes 0.39 303.24
RAP1B 0.0007395 793 GTEx DepMap Descartes 0.38 49.44
VCL 0.0006374 906 GTEx DepMap Descartes 0.36 76.23
UBASH3B 0.0006081 948 GTEx DepMap Descartes 0.10 30.81
TPM4 0.0005759 1004 GTEx DepMap Descartes 0.46 158.48
ACTN1 0.0004884 1165 GTEx DepMap Descartes 0.53 164.22
PSTPIP2 0.0004645 1206 GTEx DepMap Descartes 0.02 11.07
THBS1 0.0003666 1491 GTEx DepMap Descartes 0.57 208.05
STON2 0.0003594 1522 GTEx DepMap Descartes 0.16 56.32
MYLK 0.0003418 1597 GTEx DepMap Descartes 0.13 17.74
PDE3A 0.0003220 1686 GTEx DepMap Descartes 0.81 132.46
SLC24A3 0.0001723 2650 GTEx DepMap Descartes 0.15 59.43
TLN1 0.0001511 2860 GTEx DepMap Descartes 0.15 40.32
ANGPT1 0.0001038 3456 GTEx DepMap Descartes 0.06 16.60
ZYX 0.0000701 4008 GTEx DepMap Descartes 0.12 116.46
P2RX1 0.0000595 4210 GTEx DepMap Descartes 0.00 0.00
ITGB3 -0.0000167 5848 GTEx DepMap Descartes 0.00 0.00


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.24e-01
Mean rank of genes in gene set: 6019.93
Median rank of genes in gene set: 5108.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ETS1 0.0045344 71 GTEx DepMap Descartes 0.64 230.70
PRKCH 0.0044142 75 GTEx DepMap Descartes 0.93 551.28
MSN 0.0039449 100 GTEx DepMap Descartes 0.48 248.67
PITPNC1 0.0023172 214 GTEx DepMap Descartes 1.42 388.67
SP100 0.0019542 273 GTEx DepMap Descartes 0.47 136.45
B2M 0.0017222 305 GTEx DepMap Descartes 3.20 1767.73
ITPKB 0.0017115 311 GTEx DepMap Descartes 0.22 64.53
ABLIM1 0.0015183 353 GTEx DepMap Descartes 0.45 93.29
FOXP1 0.0011308 494 GTEx DepMap Descartes 2.58 441.97
LEF1 0.0010843 522 GTEx DepMap Descartes 0.15 48.43
ARID5B 0.0010234 557 GTEx DepMap Descartes 0.57 144.39
MBNL1 0.0009243 642 GTEx DepMap Descartes 1.12 295.68
FYN 0.0006827 854 GTEx DepMap Descartes 1.10 399.59
RCSD1 0.0006047 959 GTEx DepMap Descartes 0.17 55.72
MCTP2 0.0005797 994 GTEx DepMap Descartes 0.14 21.53
ARHGDIB 0.0005259 1091 GTEx DepMap Descartes 0.10 124.23
WIPF1 0.0003903 1405 GTEx DepMap Descartes 0.35 142.68
NCALD 0.0003502 1562 GTEx DepMap Descartes 0.34 113.26
CCND3 0.0001495 2873 GTEx DepMap Descartes 0.25 174.07
PLEKHA2 0.0001278 3126 GTEx DepMap Descartes 0.10 29.45
ANKRD44 0.0000784 3842 GTEx DepMap Descartes 0.34 58.83
CCL5 -0.0000358 6375 GTEx DepMap Descartes 0.02 12.89
PTPRC -0.0000641 7290 GTEx DepMap Descartes 0.09 12.62
CELF2 -0.0001299 9265 GTEx DepMap Descartes 0.50 77.67
BACH2 -0.0001353 9415 GTEx DepMap Descartes 0.45 60.81
LCP1 -0.0001532 9837 GTEx DepMap Descartes 0.04 12.08
IKZF1 -0.0002200 11031 GTEx DepMap Descartes 0.06 8.21
SAMD3 -0.0002231 11069 GTEx DepMap Descartes 0.04 5.16
SKAP1 -0.0002305 11162 GTEx DepMap Descartes 0.10 59.38
CD44 -0.0002322 11181 GTEx DepMap Descartes 0.72 155.96


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.91e-04
Mean rank of genes in gene set: 482
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
VWF 0.0091431 16 GTEx DepMap Descartes 1.16 223.41
MMRN2 0.0026142 179 GTEx DepMap Descartes 0.16 62.51
JAM2 0.0009170 645 GTEx DepMap Descartes 0.15 61.67
RAMP3 0.0005266 1088 GTEx DepMap Descartes 0.23 276.31


Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.60e-03
Mean rank of genes in gene set: 108
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PLVAP 0.0072142 27 GTEx DepMap Descartes 0.55 375.10
CLDN5 0.0034482 120 GTEx DepMap Descartes 0.29 143.19
SPARCL1 0.0026590 177 GTEx DepMap Descartes 0.35 166.05


T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.80e-02
Mean rank of genes in gene set: 3404.57
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRKCH 0.0044142 75 GTEx DepMap Descartes 0.93 551.28
LEF1 0.0010843 522 GTEx DepMap Descartes 0.15 48.43
MALAT1 0.0008669 681 GTEx DepMap Descartes 189.28 30769.84
NUCB2 0.0001903 2480 GTEx DepMap Descartes 0.13 45.06
CD27 0.0000397 4575 GTEx DepMap Descartes 0.01 5.38
CD8A -0.0000282 6163 GTEx DepMap Descartes 0.04 10.46
CTSW -0.0001328 9336 GTEx DepMap Descartes 0.00 0.00