Program: 2. Neuroblastoma #2.

Program: 2. Neuroblastoma #2.

Program description and justification of annotation: 2.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 NRG1 0.0098541 neuregulin 1 GTEx DepMap Descartes 14.28 1676.92
2 NXPH1 0.0098145 neurexophilin 1 GTEx DepMap Descartes 10.69 4455.23
3 EBF1 0.0092964 EBF transcription factor 1 GTEx DepMap Descartes 6.50 1599.53
4 LRRTM4 0.0090314 leucine rich repeat transmembrane neuronal 4 GTEx DepMap Descartes 6.03 2347.41
5 RYR2 0.0082173 ryanodine receptor 2 GTEx DepMap Descartes 7.52 588.12
6 PTPRD 0.0080334 protein tyrosine phosphatase receptor type D GTEx DepMap Descartes 4.37 571.14
7 DPP6 0.0076801 dipeptidyl peptidase like 6 GTEx DepMap Descartes 10.63 2854.03
8 HS3ST5 0.0075159 heparan sulfate-glucosamine 3-sulfotransferase 5 GTEx DepMap Descartes 2.70 942.71
9 CADM1 0.0071219 cell adhesion molecule 1 GTEx DepMap Descartes 6.18 941.18
10 RGS7 0.0068647 regulator of G protein signaling 7 GTEx DepMap Descartes 7.58 4037.17
11 SDK1 0.0068226 sidekick cell adhesion molecule 1 GTEx DepMap Descartes 5.61 696.61
12 BRINP3 0.0067927 BMP/retinoic acid inducible neural specific 3 GTEx DepMap Descartes 2.27 NA
13 OSBPL3 0.0067320 oxysterol binding protein like 3 GTEx DepMap Descartes 1.90 372.34
14 ROBO1 0.0066089 roundabout guidance receptor 1 GTEx DepMap Descartes 5.38 976.27
15 ROBO2 0.0065873 roundabout guidance receptor 2 GTEx DepMap Descartes 3.06 430.63
16 AUTS2 0.0064650 activator of transcription and developmental regulator AUTS2 GTEx DepMap Descartes 17.39 2992.44
17 ANKFN1 0.0064057 ankyrin repeat and fibronectin type III domain containing 1 GTEx DepMap Descartes 1.36 440.69
18 DPYD 0.0063915 dihydropyrimidine dehydrogenase GTEx DepMap Descartes 2.66 811.70
19 ELAVL2 0.0061155 ELAV like RNA binding protein 2 GTEx DepMap Descartes 2.84 961.56
20 DCC 0.0060933 DCC netrin 1 receptor GTEx DepMap Descartes 1.78 238.65
21 SORBS2 0.0060529 sorbin and SH3 domain containing 2 GTEx DepMap Descartes 4.99 1088.21
22 SOX6 0.0060181 SRY-box transcription factor 6 GTEx DepMap Descartes 1.65 246.18
23 CTNND2 0.0059146 catenin delta 2 GTEx DepMap Descartes 3.37 764.51
24 DLC1 0.0058602 DLC1 Rho GTPase activating protein GTEx DepMap Descartes 8.85 1568.03
25 AGBL4 0.0057700 AGBL carboxypeptidase 4 GTEx DepMap Descartes 2.85 941.23
26 ITGA8 0.0057133 integrin subunit alpha 8 GTEx DepMap Descartes 1.06 221.14
27 CACNA2D3 0.0057060 calcium voltage-gated channel auxiliary subunit alpha2delta 3 GTEx DepMap Descartes 5.76 2038.29
28 ALCAM 0.0055512 activated leukocyte cell adhesion molecule GTEx DepMap Descartes 2.86 840.39
29 DGKB 0.0054850 diacylglycerol kinase beta GTEx DepMap Descartes 5.23 1046.73
30 MALAT1 0.0054443 metastasis associated lung adenocarcinoma transcript 1 GTEx DepMap Descartes 307.08 46779.88
31 IL7 0.0053210 interleukin 7 GTEx DepMap Descartes 3.06 2006.66
32 EPB41L4A 0.0053194 erythrocyte membrane protein band 4.1 like 4A GTEx DepMap Descartes 0.92 264.24
33 SYN3 0.0053095 synapsin III GTEx DepMap Descartes 3.58 593.85
34 ZBTB20 0.0052120 zinc finger and BTB domain containing 20 GTEx DepMap Descartes 3.46 171.75
35 SEMA3E 0.0051211 semaphorin 3E GTEx DepMap Descartes 1.13 209.98
36 LRRC4C 0.0051119 leucine rich repeat containing 4C GTEx DepMap Descartes 1.75 576.25
37 GRIA1 0.0051029 glutamate ionotropic receptor AMPA type subunit 1 GTEx DepMap Descartes 1.12 261.71
38 SLC30A8 0.0050996 solute carrier family 30 member 8 GTEx DepMap Descartes 0.59 130.77
39 RAPGEF5 0.0050478 Rap guanine nucleotide exchange factor 5 GTEx DepMap Descartes 0.95 189.92
40 CNTNAP2 0.0050173 contactin associated protein 2 GTEx DepMap Descartes 16.58 2213.78
41 KCND2 0.0050161 potassium voltage-gated channel subfamily D member 2 GTEx DepMap Descartes 6.19 1396.67
42 UNC5D 0.0049917 unc-5 netrin receptor D GTEx DepMap Descartes 1.50 222.38
43 FSTL5 0.0049685 follistatin like 5 GTEx DepMap Descartes 0.91 260.51
44 LINGO2 0.0048978 leucine rich repeat and Ig domain containing 2 GTEx DepMap Descartes 5.89 2598.64
45 FAM155A 0.0048086 NA GTEx DepMap Descartes 9.53 1365.94
46 DNM3 0.0046580 dynamin 3 GTEx DepMap Descartes 2.48 433.43
47 MEI4 0.0046544 meiotic double-stranded break formation protein 4 GTEx DepMap Descartes 0.76 NA
48 GRID2 0.0046215 glutamate ionotropic receptor delta type subunit 2 GTEx DepMap Descartes 1.54 373.20
49 TENM3 0.0045382 teneurin transmembrane protein 3 GTEx DepMap Descartes 5.35 NA
50 B3GALT1 0.0045265 beta-1,3-galactosyltransferase 1 GTEx DepMap Descartes 1.08 282.29


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UMAP plots showing activity of gene expression program identified in community:2. Neuroblastoma #2

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
LAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2 1.04e-06 21.30 7.21 9.56e-05 6.99e-04
6AUTS2, DPYD, AGBL4, ZBTB20, FAM155A, TENM3
 86
ZHONG_PFC_MAJOR_TYPES_OPC 1.45e-06 20.04 6.80 1.08e-04 9.74e-04
6NXPH1, BRINP3, SOX6, ALCAM, LRRC4C, GRID2
 91
DESCARTES_FETAL_MUSCLE_SCHWANN_CELLS 6.23e-06 15.35 5.24 2.99e-04 4.18e-03
6LRRTM4, CADM1, ALCAM, FSTL5, GRID2, TENM3
 117
LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES 2.26e-06 13.75 5.13 1.52e-04 1.52e-03
7EBF1, SDK1, AUTS2, SORBS2, DLC1, DGKB, GRID2
 155
DESCARTES_MAIN_FETAL_OLIGODENDROCYTES 7.93e-05 20.12 5.08 3.13e-03 5.32e-02
4BRINP3, SOX6, LRRC4C, KCND2
 58
DESCARTES_FETAL_THYMUS_THYMIC_EPITHELIAL_CELLS 3.78e-07 11.63 4.91 4.66e-05 2.54e-04
9DPP6, SDK1, ROBO2, ANKFN1, SORBS2, EPB41L4A, LRRC4C, UNC5D, TENM3
 245
MANNO_MIDBRAIN_NEUROTYPES_HOPC 1.13e-07 9.93 4.55 2.53e-05 7.58e-05
11NXPH1, LRRTM4, DPP6, BRINP3, SOX6, CTNND2, LRRC4C, KCND2, FAM155A, DNM3, GRID2
 366
LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2 5.20e-06 12.04 4.50 2.78e-04 3.49e-03
7PTPRD, SDK1, SORBS2, SOX6, AGBL4, EPB41L4A, ZBTB20
 176
LAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS 5.39e-06 11.97 4.48 2.78e-04 3.62e-03
7EBF1, PTPRD, ROBO1, DPYD, DLC1, ITGA8, RAPGEF5
 177
MANNO_MIDBRAIN_NEUROTYPES_HNBGABA 3.01e-09 8.57 4.39 1.01e-06 2.02e-06
16LRRTM4, RYR2, DPP6, CADM1, BRINP3, ROBO1, ROBO2, ELAVL2, SYN3, SEMA3E, GRIA1, CNTNAP2, KCND2, FAM155A, DNM3, GRID2
 703
MANNO_MIDBRAIN_NEUROTYPES_HNBML1 4.17e-07 9.83 4.34 4.66e-05 2.80e-04
10EBF1, LRRTM4, ROBO1, ROBO2, ELAVL2, DCC, SYN3, SEMA3E, RAPGEF5, FAM155A
 328
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 2.05e-07 9.33 4.27 3.44e-05 1.38e-04
11CADM1, ELAVL2, ALCAM, SYN3, SEMA3E, RAPGEF5, CNTNAP2, FSTL5, FAM155A, DNM3, TENM3
 389
MANNO_MIDBRAIN_NEUROTYPES_HGABA 5.51e-10 7.69 4.12 3.70e-07 3.70e-07
20NXPH1, EBF1, RYR2, DPP6, CADM1, ROBO1, ROBO2, AUTS2, ELAVL2, DCC, CTNND2, ITGA8, SYN3, SEMA3E, GRIA1, RAPGEF5, CNTNAP2, FAM155A, DNM3, GRID2
 1105
DESCARTES_FETAL_ADRENAL_CHROMAFFIN_CELLS 1.02e-04 12.18 3.70 3.79e-03 6.82e-02
5RYR2, HS3ST5, ANKFN1, ELAVL2, IL7
 119
MANNO_MIDBRAIN_NEUROTYPES_HNBML5 1.14e-06 7.77 3.56 9.56e-05 7.65e-04
11RYR2, ROBO1, ROBO2, AUTS2, ELAVL2, DCC, GRIA1, RAPGEF5, CNTNAP2, FAM155A, DNM3
 465
MANNO_MIDBRAIN_NEUROTYPES_HDA 2.52e-06 7.13 3.27 1.54e-04 1.69e-03
11EBF1, DPP6, CADM1, ROBO1, ROBO2, ELAVL2, SEMA3E, GRIA1, RAPGEF5, FAM155A, DNM3
 506
LAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES 1.96e-04 10.52 3.21 6.57e-03 1.31e-01
5EBF1, DPYD, SORBS2, ITGA8, EPB41L4A
 137
FAN_EMBRYONIC_CTX_OPC 1.33e-03 15.33 2.96 3.57e-02 8.94e-01
3NXPH1, BRINP3, LRRC4C
 55
MANNO_MIDBRAIN_NEUROTYPES_HDA1 9.39e-06 6.16 2.83 4.20e-04 6.30e-03
11LRRTM4, DPP6, CADM1, ROBO1, ROBO2, ELAVL2, DCC, RAPGEF5, KCND2, FAM155A, DNM3
 584
MANNO_MIDBRAIN_NEUROTYPES_HDA2 1.99e-05 6.22 2.76 8.36e-04 1.34e-02
10LRRTM4, DPP6, ROBO1, ROBO2, ELAVL2, DCC, SOX6, CNTNAP2, FAM155A, DNM3
 513

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_KRAS_SIGNALING_DN 4.35e-02 4.05 0.80 1.00e+00 1.00e+00
3RYR2, DCC, GRID2
 200
HALLMARK_MITOTIC_SPINDLE 1.83e-01 2.64 0.31 1.00e+00 1.00e+00
2SORBS2, RAPGEF5
 199
HALLMARK_INTERFERON_GAMMA_RESPONSE 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2AUTS2, IL7
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1ALCAM
 74
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1IL7
 87
HALLMARK_INTERFERON_ALPHA_RESPONSE 3.20e-01 2.66 0.07 1.00e+00 1.00e+00
1IL7
 97
HALLMARK_PEROXISOME 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1CADM1
 104
HALLMARK_SPERMATOGENESIS 4.15e-01 1.90 0.05 1.00e+00 1.00e+00
1DCC
 135
HALLMARK_UV_RESPONSE_DN 4.35e-01 1.78 0.04 1.00e+00 1.00e+00
1DLC1
 144
HALLMARK_UV_RESPONSE_UP 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1PTPRD
 158
HALLMARK_APOPTOSIS 4.72e-01 1.59 0.04 1.00e+00 1.00e+00
1DPYD
 161
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1ALCAM
 199
HALLMARK_ESTROGEN_RESPONSE_EARLY 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1DLC1
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CADM1
 200
HALLMARK_ALLOGRAFT_REJECTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1IL7
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_DNA_REPAIR 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 150

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_AXON_GUIDANCE 1.09e-05 13.86 4.74 2.02e-03 2.02e-03
6ROBO1, ROBO2, DCC, SEMA3E, LRRC4C, UNC5D
 129
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 3.11e-03 11.23 2.19 1.93e-01 5.79e-01
3RYR2, ITGA8, CACNA2D3
 74
KEGG_CELL_ADHESION_MOLECULES_CAMS 1.83e-03 8.43 2.17 1.70e-01 3.41e-01
4CADM1, ITGA8, ALCAM, CNTNAP2
 133
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 4.29e-03 9.97 1.94 2.00e-01 7.98e-01
3RYR2, ITGA8, CACNA2D3
 83
KEGG_DILATED_CARDIOMYOPATHY 5.37e-03 9.17 1.79 2.00e-01 1.00e+00
3RYR2, ITGA8, CACNA2D3
 90
KEGG_LONG_TERM_DEPRESSION 3.13e-02 7.66 0.88 9.71e-01 1.00e+00
2GRIA1, GRID2
 70
KEGG_CARDIAC_MUSCLE_CONTRACTION 3.90e-02 6.76 0.78 1.00e+00 1.00e+00
2RYR2, CACNA2D3
 79
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1DPYD
 16
KEGG_BETA_ALANINE_METABOLISM 8.40e-02 12.14 0.29 1.00e+00 1.00e+00
1DPYD
 22
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES 9.85e-02 10.19 0.24 1.00e+00 1.00e+00
1B3GALT1
 26
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE 9.85e-02 10.19 0.24 1.00e+00 1.00e+00
1HS3ST5
 26
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.87e-01 1.93 0.23 1.00e+00 1.00e+00
2GRIA1, GRID2
 272
KEGG_GLYCEROLIPID_METABOLISM 1.77e-01 5.31 0.13 1.00e+00 1.00e+00
1DGKB
 49
KEGG_DRUG_METABOLISM_OTHER_ENZYMES 1.84e-01 5.10 0.12 1.00e+00 1.00e+00
1DPYD
 51
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 1.90e-01 4.91 0.12 1.00e+00 1.00e+00
1GRIA1
 53
KEGG_COLORECTAL_CANCER 2.19e-01 4.18 0.10 1.00e+00 1.00e+00
1DCC
 62
KEGG_LONG_TERM_POTENTIATION 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1GRIA1
 70
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 2.61e-01 3.40 0.08 1.00e+00 1.00e+00
1DGKB
 76
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 2.64e-01 3.36 0.08 1.00e+00 1.00e+00
1DGKB
 77
KEGG_ECM_RECEPTOR_INTERACTION 2.84e-01 3.07 0.08 1.00e+00 1.00e+00
1ITGA8
 84

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr1q43 2.36e-02 8.98 1.03 1.00e+00 1.00e+00
2RYR2, RGS7
 60
chr3p12 2.81e-02 8.14 0.94 1.00e+00 1.00e+00
2ROBO1, ROBO2
 66
chr8p12 2.89e-02 8.01 0.92 1.00e+00 1.00e+00
2NRG1, UNC5D
 67
chr7p21 4.26e-02 6.43 0.74 1.00e+00 1.00e+00
2NXPH1, DGKB
 83
chr7p15 5.52e-02 5.54 0.64 1.00e+00 1.00e+00
2OSBPL3, RAPGEF5
 96
chr5q33 6.89e-02 4.87 0.57 1.00e+00 1.00e+00
2EBF1, GRIA1
 109
chr11p12 7.30e-02 14.16 0.33 1.00e+00 1.00e+00
1LRRC4C
 19
chr9p23 7.30e-02 14.16 0.33 1.00e+00 1.00e+00
1PTPRD
 19
chr3q13 1.67e-01 2.82 0.33 1.00e+00 1.00e+00
2ALCAM, ZBTB20
 187
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1DLC1
 45
chr2p12 1.90e-01 4.91 0.12 1.00e+00 1.00e+00
1LRRTM4
 53
chr13q33 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1FAM155A
 55
chr5q22 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1EPB41L4A
 55
chr1p33 2.13e-01 4.32 0.11 1.00e+00 1.00e+00
1AGBL4
 60
chr10p13 2.25e-01 4.05 0.10 1.00e+00 1.00e+00
1ITGA8
 64
chr7q35 2.28e-01 3.99 0.10 1.00e+00 1.00e+00
1CNTNAP2
 65
chr4q22 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1GRID2
 70
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1BRINP3
 71
chr17q22 2.90e-01 3.00 0.07 1.00e+00 1.00e+00
1ANKFN1
 86
chr6q14 3.09e-01 2.77 0.07 1.00e+00 1.00e+00
1MEI4
 93

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
EN1_01 9.45e-04 10.15 2.61 1.99e-01 1.00e+00
4NRG1, SORBS2, GRIA1, RAPGEF5
 111
OCT1_Q6 6.26e-04 6.41 2.21 1.99e-01 7.10e-01
6NXPH1, EBF1, CADM1, BRINP3, DLC1, ZBTB20
 272
STAT5A_04 1.45e-03 6.64 2.04 1.99e-01 1.00e+00
5PTPRD, ELAVL2, AGBL4, GRIA1, GRID2
 214
SOX9_B1 2.29e-03 5.96 1.83 1.99e-01 1.00e+00
5EBF1, CADM1, ELAVL2, SORBS2, DLC1
 238
TCCATTKW_UNKNOWN 2.42e-03 5.88 1.81 1.99e-01 1.00e+00
5LRRTM4, ELAVL2, SORBS2, CTNND2, CACNA2D3
 241
TAATTA_CHX10_01 7.99e-04 3.85 1.71 1.99e-01 9.05e-01
10NXPH1, CADM1, ROBO1, ELAVL2, SORBS2, CTNND2, DLC1, ITGA8, CACNA2D3, ZBTB20
 823
T3R_Q6 3.12e-03 5.53 1.70 1.99e-01 1.00e+00
5LRRTM4, RGS7, ELAVL2, CTNND2, CACNA2D3
 256
TCF11_01 3.23e-03 5.49 1.69 1.99e-01 1.00e+00
5NRG1, EBF1, LRRTM4, CADM1, GRIA1
 258
SRY_02 3.28e-03 5.47 1.68 1.99e-01 1.00e+00
5EBF1, CADM1, ELAVL2, SOX6, RAPGEF5
 259
CDX2_Q5 3.50e-03 5.38 1.65 1.99e-01 1.00e+00
5CADM1, ROBO1, DPYD, ELAVL2, AGBL4
 263
OCT_Q6 3.73e-03 5.30 1.63 1.99e-01 1.00e+00
5NXPH1, EBF1, CADM1, BRINP3, FSTL5
 267
AFP1_Q6 3.79e-03 5.28 1.62 1.99e-01 1.00e+00
5HS3ST5, DPYD, ELAVL2, CACNA2D3, CNTNAP2
 268
OCT1_B 3.84e-03 5.26 1.62 1.99e-01 1.00e+00
5NXPH1, EBF1, LRRTM4, CADM1, FSTL5
 269
OCT_C 3.90e-03 5.24 1.61 1.99e-01 1.00e+00
5EBF1, CADM1, ZBTB20, FSTL5, GRID2
 270
STAT6_01 4.03e-03 5.20 1.60 1.99e-01 1.00e+00
5RYR2, CADM1, BRINP3, CACNA2D3, GRID2
 272
CRX_Q4 4.15e-03 5.16 1.59 1.99e-01 1.00e+00
5LRRTM4, DPYD, DLC1, ZBTB20, GRID2
 274
AACTTT_UNKNOWN 5.19e-04 3.08 1.58 1.99e-01 5.88e-01
16NRG1, NXPH1, EBF1, LRRTM4, CADM1, BRINP3, AUTS2, ELAVL2, SOX6, CTNND2, CACNA2D3, ALCAM, ZBTB20, RAPGEF5, CNTNAP2, GRID2
 1928
GR_Q6 4.21e-03 5.14 1.58 1.99e-01 1.00e+00
5BRINP3, AUTS2, ELAVL2, CTNND2, KCND2
 275
OCT1_Q5_01 4.21e-03 5.14 1.58 1.99e-01 1.00e+00
5NXPH1, EBF1, CADM1, BRINP3, FSTL5
 275
CDP_02 9.53e-03 7.39 1.45 3.18e-01 1.00e+00
3CADM1, CACNA2D3, DGKB
 111

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_AXON_MIDLINE_CHOICE_POINT_RECOGNITION 1.54e-04 172.68 14.09 6.07e-02 1.00e+00
2ROBO1, ROBO2
 5
GOBP_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT 2.31e-04 129.66 11.45 7.53e-02 1.00e+00
2ROBO1, ROBO2
 6
GOBP_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES 1.09e-06 33.01 9.74 2.79e-03 8.13e-03
5PTPRD, CADM1, ALCAM, GRID2, TENM3
 47
GOBP_AXON_CHOICE_POINT_RECOGNITION 3.22e-04 103.49 9.64 9.27e-02 1.00e+00
2ROBO1, ROBO2
 7
GOBP_NEGATIVE_CHEMOTAXIS 3.17e-05 25.85 6.47 1.54e-02 2.37e-01
4NRG1, ROBO1, ROBO2, SEMA3E
 46
GOBP_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION 8.35e-04 57.69 5.91 1.69e-01 1.00e+00
2ROBO1, ROBO2
 11
GOBP_REGULATION_OF_POSTSYNAPTIC_SPECIALIZATION_ASSEMBLY 8.35e-04 57.69 5.91 1.69e-01 1.00e+00
2PTPRD, GRID2
 11
GOBP_REGULATION_OF_HEART_MORPHOGENESIS 8.35e-04 57.69 5.91 1.69e-01 1.00e+00
2ROBO1, ROBO2
 11
GOBP_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES 7.87e-08 11.88 5.24 5.89e-04 5.89e-04
10PTPRD, CADM1, SDK1, ROBO1, ROBO2, ALCAM, LRRC4C, UNC5D, GRID2, TENM3
 273
GOBP_NETRIN_ACTIVATED_SIGNALING_PATHWAY 1.18e-03 47.19 4.96 2.00e-01 1.00e+00
2DCC, UNC5D
 13
GOBP_REGULATION_OF_EXCITATORY_SYNAPSE_ASSEMBLY 1.18e-03 47.19 4.96 2.00e-01 1.00e+00
2PTPRD, GRID2
 13
GOBP_REGULATION_OF_POSTSYNAPTIC_DENSITY_ORGANIZATION 1.37e-03 43.30 4.59 2.28e-01 1.00e+00
2PTPRD, GRID2
 14
GOBP_PULMONARY_VALVE_MORPHOGENESIS 2.03e-03 34.68 3.75 3.08e-01 1.00e+00
2ROBO1, ROBO2
 17
GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT 2.89e-04 14.11 3.60 9.01e-02 1.00e+00
4ROBO1, ROBO2, DCC, AGBL4
 81
GOBP_NEURON_RECOGNITION 7.92e-04 18.54 3.56 1.69e-01 1.00e+00
3ROBO1, ROBO2, CNTNAP2
 46
GOBP_HEART_FIELD_SPECIFICATION 2.28e-03 32.49 3.53 3.28e-01 1.00e+00
2ROBO1, ROBO2
 18
GOBP_SYNAPSE_ASSEMBLY 5.61e-05 10.21 3.51 2.47e-02 4.20e-01
6PTPRD, SDK1, ROBO2, LINGO2, DNM3, GRID2
 173
GOBP_SYNAPSE_ORGANIZATION 3.11e-06 7.78 3.44 4.65e-03 2.33e-02
10PTPRD, SDK1, ROBO2, CTNND2, DGKB, SEMA3E, LRRC4C, LINGO2, DNM3, GRID2
 412
GOBP_REGULATION_OF_POSTSYNAPSE_ORGANIZATION 3.79e-04 13.08 3.35 1.05e-01 1.00e+00
4PTPRD, DGKB, DNM3, GRID2
 87
GOBP_RETINAL_GANGLION_CELL_AXON_GUIDANCE 2.54e-03 30.58 3.34 3.52e-01 1.00e+00
2ROBO2, ALCAM
 19

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD8_TCELL_DN 2.83e-03 7.44 1.92 1.00e+00 1.00e+00
4CADM1, OSBPL3, ITGA8, ALCAM
 150
GSE37605_TREG_VS_TCONV_C57BL6_FOXP3_FUSION_GFP_DN 5.06e-03 6.28 1.62 1.00e+00 1.00e+00
4CADM1, OSBPL3, CACNA2D3, ALCAM
 177
GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_DN 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4CADM1, DPYD, ALCAM, SEMA3E
 198
GSE7460_WT_VS_FOXP3_HET_ACT_TCONV_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4RYR2, CTNND2, ZBTB20, GRID2
 199
GSE19825_NAIVE_VS_DAY3_EFF_CD8_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4NXPH1, ELAVL2, KCND2, FSTL5
 200
GSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4DPP6, ALCAM, SYN3, FAM155A
 200
GSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4NXPH1, SOX6, CACNA2D3, ALCAM
 200
GSE41176_WT_VS_TAK1_KO_ANTI_IGM_STIM_BCELL_1H_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4DPYD, DGKB, CNTNAP2, KCND2
 200
GSE37605_TREG_VS_TCONV_C57BL6_FOXP3_FUSION_GFP_UP 1.61e-02 6.04 1.19 1.00e+00 1.00e+00
3RGS7, CACNA2D3, FAM155A
 135
GSE13522_WT_VS_IFNG_KO_SKIN_UP 1.70e-02 5.91 1.16 1.00e+00 1.00e+00
3ROBO1, ANKFN1, FSTL5
 138
GSE12484_HEALTHY_VS_PERIDONTITIS_NEUTROPHILS_UP 1.73e-02 5.87 1.15 1.00e+00 1.00e+00
3NXPH1, CADM1, SOX6
 139
GSE12507_PDC_CELL_LINE_VS_IMMATUE_T_CELL_LINE_DN 1.90e-02 5.66 1.11 1.00e+00 1.00e+00
3RGS7, ITGA8, IL7
 144
GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_UP 2.19e-02 5.35 1.05 1.00e+00 1.00e+00
3CADM1, BRINP3, KCND2
 152
GSE40274_FOXP3_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 2.45e-02 5.11 1.01 1.00e+00 1.00e+00
3ALCAM, RAPGEF5, FSTL5
 159
GSE4590_PRE_BCELL_VS_LARGE_PRE_BCELL_UP 2.49e-02 5.08 1.00 1.00e+00 1.00e+00
3DPYD, IL7, GRID2
 160
GSE6269_E_COLI_VS_STREP_PNEUMO_INF_PBMC_UP 2.82e-02 4.83 0.95 1.00e+00 1.00e+00
3PTPRD, ROBO1, AUTS2
 168
GSE46606_UNSTIM_VS_CD40L_IL2_IL5_3DAY_STIMULATED_IRF4_KO_BCELL_UP 3.54e-02 4.41 0.87 1.00e+00 1.00e+00
3ROBO2, CTNND2, CNTNAP2
 184
GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_24H_ACT_CD4_TCELL_UP 3.64e-02 4.36 0.86 1.00e+00 1.00e+00
3PTPRD, SORBS2, DLC1
 186
GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_3H_UP 3.74e-02 4.31 0.85 1.00e+00 1.00e+00
3RGS7, LRRC4C, FSTL5
 188
GSE45365_BCELL_VS_CD8_TCELL_DN 3.74e-02 4.31 0.85 1.00e+00 1.00e+00
3LRRTM4, SOX6, SYN3
 188

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
NRG1 1 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Cell surface receptor - does not have predicted DBDs
EBF1 3 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RGS7 10 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SORBS2 21 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SOX6 22 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZBTB20 34 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RAPGEF5 39 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
KLF12 59 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZFPM2 81 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None FOG-proteins use some of their zinc-fingers to interact with the GATA proteins. Other C2H2 ZFs are probably also capable of binding DNA (PMID: 10329627).
TSHZ2 89 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Also contains an atypical homodomain (Uniprot) not identified by Pfam.
NTRK1 93 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Membrane bound receptor protein
ZFHX3 94 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CAMTA1 102 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Binds CGCATTGCG based on EMSA performed in (PMID: 25049392)
SOX4 113 Yes Known motif Monomer or homomultimer High-throughput in vitro None Also binds ssDNA loops.
MYRFL 116 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Related to other MYRF TFs, which have related PBM motifs
ERC1 129 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
MACF1 141 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because Vasquerizas 2009 includes it with an x. No DBD and no other data to support being a TF.
TLE4 160 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None TLE4 is a Groucho protein (co-repressor)
HIVEP3 163 Yes Inferred motif Monomer or homomultimer In vivo/Misc source Has a putative AT-hook Binds to NFKB-like consensus sequence to repress transcription (PMID: 21189157). PWMs for HIVEP1 and 2 in Transfac and Hocomoco are also NFKB-like.
RORA 172 Yes Known motif Monomer or homomultimer High-throughput in vitro None None

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB06_CATCGAAAGTTAAGTG-1 Neurons:adrenal_medulla_cell_line 0.22 920.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_2lox-22: 0.27
NB06_CACCAGGCACAACGTT-1 Neurons:adrenal_medulla_cell_line 0.26 830.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.38, Astrocyte:Embryonic_stem_cell-derived: 0.38, Neurons:ES_cell-derived_neural_precursor: 0.34, iPS_cells:PDB_1lox-21Puro-20: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33, iPS_cells:PDB_2lox-22: 0.32, Embryonic_stem_cells: 0.32
NB12_CCGTACTGTCTTCTCG-1 Neurons:adrenal_medulla_cell_line 0.25 731.16
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-21Puro-26: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.29, iPS_cells:PDB_1lox-17Puro-5: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_2lox-22: 0.27
NB06_CACTCCACAATCTACG-1 Neurons:adrenal_medulla_cell_line 0.19 726.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neurons:ES_cell-derived_neural_precursor: 0.3, Embryonic_stem_cells: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, MSC: 0.25, Tissue_stem_cells:CD326-CD56+: 0.25
NB06_TCACAAGCACAGCGTC-1 Neurons:adrenal_medulla_cell_line 0.25 669.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, Embryonic_stem_cells: 0.27, iPS_cells:PDB_2lox-22: 0.27
NB12_ATAGACCTCAGCTGGC-1 Neurons:adrenal_medulla_cell_line 0.24 657.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.35, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, Embryonic_stem_cells: 0.3, iPS_cells:PDB_2lox-22: 0.3
NB06_CACCACTAGATATACG-1 Neurons:adrenal_medulla_cell_line 0.26 647.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.5, Neuroepithelial_cell:ESC-derived: 0.43, Astrocyte:Embryonic_stem_cell-derived: 0.42, Neurons:ES_cell-derived_neural_precursor: 0.39, iPS_cells:PDB_1lox-21Puro-20: 0.38, iPS_cells:PDB_1lox-17Puro-10: 0.38, iPS_cells:PDB_1lox-21Puro-26: 0.38, iPS_cells:PDB_1lox-17Puro-5: 0.38, iPS_cells:PDB_2lox-22: 0.37, Embryonic_stem_cells: 0.37
NB06_CGTTCTGAGGCTCATT-1 Neurons:adrenal_medulla_cell_line 0.22 637.64
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:skin_fibroblast-derived: 0.2
NB07_CGAACATAGTGCCATT-1 Neurons:adrenal_medulla_cell_line 0.23 610.34
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, Embryonic_stem_cells: 0.25, iPS_cells:PDB_2lox-22: 0.24
NB12_CTACGTCTCTCTGCTG-1 Neurons:adrenal_medulla_cell_line 0.19 608.34
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:CRL2097_foreskin: 0.23, Embryonic_stem_cells: 0.23
NB12_TGAGGGAGTAAATGAC-1 Neurons:adrenal_medulla_cell_line 0.23 596.19
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Embryonic_stem_cells: 0.24, iPS_cells:PDB_2lox-22: 0.24
NB12_TTTGCGCTCAGGATCT-1 Neurons:adrenal_medulla_cell_line 0.22 589.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:skin_fibroblast-derived: 0.24
NB07_CTAATGGGTTACGTCA-1 Neurons:adrenal_medulla_cell_line 0.23 585.99
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, Embryonic_stem_cells: 0.22, iPS_cells:skin_fibroblast-derived: 0.21
NB12_ACACCAAAGGACCACA-1 Neurons:adrenal_medulla_cell_line 0.25 580.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.31, iPS_cells:PDB_1lox-21Puro-26: 0.31, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-22: 0.3, Embryonic_stem_cells: 0.3
NB07_AAGACCTAGACTAAGT-1 Neurons:adrenal_medulla_cell_line 0.20 572.13
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_2lox-22: 0.23
NB06_TCTCTAACACTGAAGG-1 Neurons:adrenal_medulla_cell_line 0.22 552.39
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.29, Neuroepithelial_cell:ESC-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_2lox-22: 0.22
NB07_GGAACTTCAATAAGCA-1 Neurons:adrenal_medulla_cell_line 0.22 549.25
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.37, Astrocyte:Embryonic_stem_cell-derived: 0.31, Neuroepithelial_cell:ESC-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-17Puro-5: 0.26, Embryonic_stem_cells: 0.25, iPS_cells:PDB_2lox-22: 0.25
NB07_CCACCTACACCCATGG-1 Neurons:adrenal_medulla_cell_line 0.24 545.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.38, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.29, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_2lox-22: 0.27, iPS_cells:PDB_2lox-21: 0.27
NB12_CCTACCAGTTTGACTG-1 Neurons:adrenal_medulla_cell_line 0.20 512.27
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:skin_fibroblast-derived: 0.21
NB06_ATCTACTAGTTGAGTA-1 Neurons:adrenal_medulla_cell_line 0.21 508.73
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_2lox-22: 0.22
NB07_TCAATCTTCGCACTCT-1 Neurons:adrenal_medulla_cell_line 0.19 508.25
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_2lox-22: 0.15
NB07_AGCTTGATCTGTACGA-1 Neurons:adrenal_medulla_cell_line 0.23 505.06
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.21
NB06_CAGTAACGTAAACACA-1 Neurons:adrenal_medulla_cell_line 0.24 504.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.46, Neuroepithelial_cell:ESC-derived: 0.39, Astrocyte:Embryonic_stem_cell-derived: 0.39, Neurons:ES_cell-derived_neural_precursor: 0.36, iPS_cells:PDB_1lox-21Puro-20: 0.33, Embryonic_stem_cells: 0.33, iPS_cells:PDB_1lox-17Puro-10: 0.33, iPS_cells:PDB_1lox-21Puro-26: 0.33, Tissue_stem_cells:CD326-CD56+: 0.33, iPS_cells:PDB_1lox-17Puro-5: 0.33
NB12_CCTATTAGTACTTCTT-1 Neurons:adrenal_medulla_cell_line 0.21 466.60
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:skin_fibroblast-derived: 0.21
NB06_CTCATTATCTGACCTC-1 Neurons:adrenal_medulla_cell_line 0.19 462.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, Embryonic_stem_cells: 0.18, iPS_cells:PDB_2lox-22: 0.18
NB07_TTATGCTAGTTACGGG-1 Neurons:adrenal_medulla_cell_line 0.20 456.30
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, Embryonic_stem_cells: 0.2, iPS_cells:PDB_2lox-22: 0.2
NB07_GATCAGTTCTAAGCCA-1 Neurons:adrenal_medulla_cell_line 0.23 453.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.22
NB12_GAACATCTCTTCAACT-1 Neurons:adrenal_medulla_cell_line 0.22 448.09
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:skin_fibroblast-derived: 0.23
NB07_TTGCGTCTCCTTTCTC-1 Neurons:adrenal_medulla_cell_line 0.21 445.65
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, iPS_cells:PDB_2lox-22: 0.22, Embryonic_stem_cells: 0.22
NB06_AGGGATGAGTCAAGCG-1 Neurons:adrenal_medulla_cell_line 0.21 444.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_2lox-22: 0.16
NB07_TTCTCCTAGTGACATA-1 Neurons:adrenal_medulla_cell_line 0.23 441.50
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_2lox-22: 0.23
NB12_GTACTTTTCGCTTGTC-1 Neurons:adrenal_medulla_cell_line 0.20 440.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.21
NB07_AAATGCCTCGCACTCT-1 Neurons:adrenal_medulla_cell_line 0.19 436.81
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_2lox-22: 0.2, Embryonic_stem_cells: 0.2
NB06_ACCTTTACAAATTGCC-1 Neurons:adrenal_medulla_cell_line 0.23 432.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.39, Neuroepithelial_cell:ESC-derived: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.32, Neurons:ES_cell-derived_neural_precursor: 0.29, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, Embryonic_stem_cells: 0.27, iPS_cells:PDB_2lox-22: 0.27
NB07_CACATAGTCCTACAGA-1 Neurons:adrenal_medulla_cell_line 0.21 427.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_2lox-22: 0.2
NB06_GATCTAGAGACGCAAC-1 Neurons:adrenal_medulla_cell_line 0.23 425.44
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_2lox-22: 0.22
NB07_CGCTATCCAAGCCGCT-1 Neurons:adrenal_medulla_cell_line 0.20 419.72
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB12_TTTGCGCGTCCAGTTA-1 Neurons:adrenal_medulla_cell_line 0.21 417.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21
NB13_CTAACTTAGCCGCCTA-1 Neurons:adrenal_medulla_cell_line 0.23 416.88
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neuroepithelial_cell:ESC-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.31, iPS_cells:PDB_1lox-21Puro-20: 0.3, iPS_cells:PDB_1lox-21Puro-26: 0.3, iPS_cells:PDB_1lox-17Puro-10: 0.3, iPS_cells:PDB_1lox-17Puro-5: 0.3, Embryonic_stem_cells: 0.29, iPS_cells:PDB_2lox-22: 0.29
NB07_ATTTCTGGTTATCACG-1 Neurons:adrenal_medulla_cell_line 0.22 413.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB12_GGCGTGTGTCTTTCAT-1 Neurons:adrenal_medulla_cell_line 0.22 406.95
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.2
NB07_ATGTGTGTCCGTAGTA-1 Neurons:adrenal_medulla_cell_line 0.19 404.21
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, Embryonic_stem_cells: 0.18, iPS_cells:PDB_2lox-22: 0.18
NB07_CGCGGTAGTCCGTTAA-1 Neurons:adrenal_medulla_cell_line 0.25 394.26
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.42, Neuroepithelial_cell:ESC-derived: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.34, Neurons:ES_cell-derived_neural_precursor: 0.33, iPS_cells:PDB_1lox-21Puro-20: 0.32, iPS_cells:PDB_1lox-17Puro-10: 0.32, iPS_cells:PDB_1lox-21Puro-26: 0.32, iPS_cells:PDB_1lox-17Puro-5: 0.31, iPS_cells:PDB_2lox-22: 0.31, Embryonic_stem_cells: 0.3
NB12_TGGACGCCAATTGCTG-1 Neurons:adrenal_medulla_cell_line 0.21 389.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21
NB06_CAGATCAAGAAGCCCA-1 Neurons:adrenal_medulla_cell_line 0.22 387.15
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.21
NB06_CCCAATCCATGCAATC-1 Neurons:adrenal_medulla_cell_line 0.20 381.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:skin_fibroblast-derived: 0.17, Embryonic_stem_cells: 0.17
NB06_ACTTTCAAGGGTTTCT-1 Neurons:adrenal_medulla_cell_line 0.21 379.98
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_2lox-22: 0.19
NB06_ACTATCTGTACAGCAG-1 Neurons:adrenal_medulla_cell_line 0.22 377.31
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, Embryonic_stem_cells: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_2lox-22: 0.22
NB07_CCTCAGTTCGGTGTCG-1 Neurons:adrenal_medulla_cell_line 0.18 373.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB12_TTATGCTAGCTGTCTA-1 Neurons:adrenal_medulla_cell_line 0.20 373.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:skin_fibroblast-derived: 0.22


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Adrenergic mature (olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These markers are specific to the mature adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.02e-03
Mean rank of genes in gene set: 107
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NTRK1 0.0032534 93 GTEx DepMap Descartes 0.58 261.82
GAP43 0.0028822 121 GTEx DepMap Descartes 1.34 926.61


Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.35e-03
Mean rank of genes in gene set: 3662.18
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
NRG1 0.0098541 1 GTEx DepMap Descartes 14.28 1676.92
ELAVL4 0.0034890 86 GTEx DepMap Descartes 2.69 866.51
MAP1B 0.0020545 210 GTEx DepMap Descartes 3.17 338.54
STMN2 0.0012849 403 GTEx DepMap Descartes 4.48 3037.69
RGS5 0.0009890 562 GTEx DepMap Descartes 1.20 266.08
TH 0.0009592 583 GTEx DepMap Descartes 1.19 819.63
RTN1 0.0008397 665 GTEx DepMap Descartes 3.59 1305.32
DBH 0.0004944 1104 GTEx DepMap Descartes 0.89 410.35
UCHL1 -0.0009033 12081 GTEx DepMap Descartes 1.50 1162.83
ISL1 -0.0009593 12163 GTEx DepMap Descartes 0.67 341.76
MLLT11 -0.0013177 12426 GTEx DepMap Descartes 0.59 307.07


Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.79e-03
Mean rank of genes in gene set: 1309.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GAP43 0.0028822 121 GTEx DepMap Descartes 1.34 926.61
BCL2 0.0007421 745 GTEx DepMap Descartes 2.43 408.62
NPY 0.0000625 3063 GTEx DepMap Descartes 6.96 12190.36




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 6848.92
Median rank of genes in gene set: 7802
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CADM1 0.0071219 9 GTEx DepMap Descartes 6.18 941.18
AUTS2 0.0064650 16 GTEx DepMap Descartes 17.39 2992.44
ELAVL2 0.0061155 19 GTEx DepMap Descartes 2.84 961.56
FAM155A 0.0048086 45 GTEx DepMap Descartes 9.53 1365.94
TMEM178B 0.0039742 63 GTEx DepMap Descartes 3.40 NA
MARCH11 0.0036818 75 GTEx DepMap Descartes 2.50 NA
ELAVL4 0.0034890 86 GTEx DepMap Descartes 2.69 866.51
GAP43 0.0028822 121 GTEx DepMap Descartes 1.34 926.61
MAPT 0.0028046 128 GTEx DepMap Descartes 1.60 300.47
NRCAM 0.0026228 143 GTEx DepMap Descartes 1.52 301.94
NBEA 0.0024167 166 GTEx DepMap Descartes 3.03 352.52
RUNDC3B 0.0021531 194 GTEx DepMap Descartes 0.92 297.80
PPP1R9A 0.0021446 195 GTEx DepMap Descartes 1.05 125.71
MIAT 0.0020780 203 GTEx DepMap Descartes 1.29 171.06
MAP1B 0.0020545 210 GTEx DepMap Descartes 3.17 338.54
NNAT 0.0020427 213 GTEx DepMap Descartes 1.51 1529.66
NEFM 0.0020036 219 GTEx DepMap Descartes 0.38 140.33
UNC79 0.0016322 282 GTEx DepMap Descartes 1.31 186.39
BMPR1B 0.0015503 300 GTEx DepMap Descartes 3.93 895.44
RBMS3 0.0015198 305 GTEx DepMap Descartes 5.30 794.16
SCN3A 0.0015075 310 GTEx DepMap Descartes 1.25 181.94
TMOD1 0.0014106 341 GTEx DepMap Descartes 1.29 495.38
CLASP2 0.0013728 357 GTEx DepMap Descartes 2.63 467.70
ACTL6B 0.0013579 367 GTEx DepMap Descartes 0.67 556.47
CACNA1B 0.0013508 370 GTEx DepMap Descartes 1.56 200.04
NCOA7 0.0013411 373 GTEx DepMap Descartes 1.00 NA
RNF165 0.0012951 398 GTEx DepMap Descartes 0.75 123.14
STMN2 0.0012849 403 GTEx DepMap Descartes 4.48 3037.69
GRB10 0.0012283 436 GTEx DepMap Descartes 0.27 63.41
RNF144A 0.0011527 476 GTEx DepMap Descartes 0.56 128.05


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8082.64
Median rank of genes in gene set: 9297
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ROBO1 0.0066089 14 GTEx DepMap Descartes 5.38 976.27
DLC1 0.0058602 24 GTEx DepMap Descartes 8.85 1568.03
ATP2B4 0.0031173 104 GTEx DepMap Descartes 0.74 111.01
DMD 0.0021943 186 GTEx DepMap Descartes 1.19 109.99
ATXN1 0.0018402 237 GTEx DepMap Descartes 1.88 228.28
NRP1 0.0015589 298 GTEx DepMap Descartes 0.86 187.28
CD44 0.0014306 332 GTEx DepMap Descartes 1.08 259.52
STAT3 0.0013664 362 GTEx DepMap Descartes 0.63 158.96
EXT1 0.0013200 384 GTEx DepMap Descartes 1.54 237.03
SCPEP1 0.0012435 427 GTEx DepMap Descartes 0.28 193.43
PDE7B 0.0011815 460 GTEx DepMap Descartes 0.19 45.19
KIF13A 0.0010937 511 GTEx DepMap Descartes 0.39 72.44
LOXL2 0.0010409 537 GTEx DepMap Descartes 0.15 49.02
PLAGL1 0.0007894 698 GTEx DepMap Descartes 0.31 65.88
NR3C1 0.0007243 769 GTEx DepMap Descartes 0.25 44.36
ADAM19 0.0007211 774 GTEx DepMap Descartes 0.19 36.97
FILIP1L 0.0007075 795 GTEx DepMap Descartes 0.54 154.51
ACADVL 0.0006833 822 GTEx DepMap Descartes 0.48 261.72
CDH11 0.0006569 849 GTEx DepMap Descartes 0.19 34.32
LPP 0.0006111 908 GTEx DepMap Descartes 0.72 51.73
RIN2 0.0005638 977 GTEx DepMap Descartes 0.15 43.22
TMEFF2 0.0005522 999 GTEx DepMap Descartes 0.39 156.09
RECK 0.0005453 1011 GTEx DepMap Descartes 0.27 72.57
NBR1 0.0005108 1061 GTEx DepMap Descartes 0.30 78.37
AMMECR1 0.0005044 1076 GTEx DepMap Descartes 0.13 33.14
SNAP23 0.0004985 1090 GTEx DepMap Descartes 0.17 84.39
HIBADH 0.0004958 1096 GTEx DepMap Descartes 0.43 286.79
LIFR 0.0004641 1153 GTEx DepMap Descartes 0.19 23.27
ITM2C 0.0004550 1176 GTEx DepMap Descartes 0.16 101.61
PCSK5 0.0004482 1191 GTEx DepMap Descartes 0.17 21.31


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.95e-01
Mean rank of genes in gene set: 6582.03
Median rank of genes in gene set: 7703
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FRMD5 0.0036178 78 GTEx DepMap Descartes 2.13 547.97
IGF1R 0.0014864 317 GTEx DepMap Descartes 1.29 135.38
CLU 0.0013219 381 GTEx DepMap Descartes 0.68 311.31
PEG3 0.0009656 580 GTEx DepMap Descartes 0.39 NA
JAKMIP2 0.0007576 729 GTEx DepMap Descartes 0.67 93.31
DNER 0.0005915 939 GTEx DepMap Descartes 0.24 101.17
NPC1 0.0004152 1256 GTEx DepMap Descartes 0.26 70.37
HMGCS1 0.0003717 1363 GTEx DepMap Descartes 0.23 54.92
SH3PXD2B 0.0001627 2260 GTEx DepMap Descartes 0.14 22.95
SLC1A2 0.0000636 3055 GTEx DepMap Descartes 0.31 32.98
STAR -0.0000478 4376 GTEx DepMap Descartes 0.00 0.73
INHA -0.0000794 4876 GTEx DepMap Descartes 0.01 8.93
FREM2 -0.0001636 6268 GTEx DepMap Descartes 0.01 0.41
FDXR -0.0002073 6973 GTEx DepMap Descartes 0.04 20.29
FDPS -0.0002144 7083 GTEx DepMap Descartes 0.32 194.34
GSTA4 -0.0002211 7194 GTEx DepMap Descartes 0.22 166.51
GRAMD1B -0.0002221 7212 GTEx DepMap Descartes 0.07 9.42
CYB5B -0.0002498 7623 GTEx DepMap Descartes 0.19 58.09
HMGCR -0.0002602 7783 GTEx DepMap Descartes 0.17 46.46
FDX1 -0.0002783 8026 GTEx DepMap Descartes 0.03 13.74
DHCR24 -0.0002861 8148 GTEx DepMap Descartes 0.08 18.69
DHCR7 -0.0002979 8335 GTEx DepMap Descartes 0.02 8.50
POR -0.0003019 8405 GTEx DepMap Descartes 0.10 51.83
LDLR -0.0003398 8909 GTEx DepMap Descartes 0.05 10.86
SCAP -0.0003500 9031 GTEx DepMap Descartes 0.16 46.92
ERN1 -0.0003795 9377 GTEx DepMap Descartes 0.04 5.34
BAIAP2L1 -0.0003805 9390 GTEx DepMap Descartes 0.02 5.95
TM7SF2 -0.0003879 9479 GTEx DepMap Descartes 0.08 46.62
SGCZ -0.0004021 9625 GTEx DepMap Descartes 0.31 45.58
SLC16A9 -0.0004099 9718 GTEx DepMap Descartes 0.10 28.34


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.14e-03
Mean rank of genes in gene set: 4891
Median rank of genes in gene set: 1918
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RYR2 0.0082173 5 GTEx DepMap Descartes 7.52 588.12
HS3ST5 0.0075159 8 GTEx DepMap Descartes 2.70 942.71
ANKFN1 0.0064057 17 GTEx DepMap Descartes 1.36 440.69
ELAVL2 0.0061155 19 GTEx DepMap Descartes 2.84 961.56
IL7 0.0053210 31 GTEx DepMap Descartes 3.06 2006.66
TMEM132C 0.0037799 73 GTEx DepMap Descartes 3.81 1019.44
MARCH11 0.0036818 75 GTEx DepMap Descartes 2.50 NA
RBFOX1 0.0034736 88 GTEx DepMap Descartes 6.81 1790.47
NTRK1 0.0032534 93 GTEx DepMap Descartes 0.58 261.82
FAT3 0.0030731 106 GTEx DepMap Descartes 0.62 42.50
KCNB2 0.0029505 118 GTEx DepMap Descartes 2.12 728.79
GAP43 0.0028822 121 GTEx DepMap Descartes 1.34 926.61
MAP1B 0.0020545 210 GTEx DepMap Descartes 3.17 338.54
CNKSR2 0.0016523 276 GTEx DepMap Descartes 0.97 155.21
STMN2 0.0012849 403 GTEx DepMap Descartes 4.48 3037.69
TUBB2A 0.0009357 596 GTEx DepMap Descartes 0.89 684.64
PLXNA4 0.0009189 611 GTEx DepMap Descartes 0.48 45.25
REEP1 0.0007210 775 GTEx DepMap Descartes 0.40 126.70
CNTFR 0.0006768 832 GTEx DepMap Descartes 0.28 184.16
TMEFF2 0.0005522 999 GTEx DepMap Descartes 0.39 156.09
MAB21L1 0.0002234 1918 GTEx DepMap Descartes 0.22 93.95
NPY 0.0000625 3063 GTEx DepMap Descartes 6.96 12190.36
TUBB2B 0.0000543 3138 GTEx DepMap Descartes 2.44 1573.80
BASP1 -0.0000036 3772 GTEx DepMap Descartes 1.05 740.86
RPH3A -0.0000346 4188 GTEx DepMap Descartes 0.04 8.87
EPHA6 -0.0000435 4313 GTEx DepMap Descartes 0.86 258.20
GREM1 -0.0002851 8135 GTEx DepMap Descartes 0.00 0.48
RGMB -0.0003749 9331 GTEx DepMap Descartes 0.35 100.71
PTCHD1 -0.0004925 10462 GTEx DepMap Descartes 0.12 11.01
TUBA1A -0.0006068 11211 GTEx DepMap Descartes 4.49 2987.08


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.37e-01
Mean rank of genes in gene set: 6851.47
Median rank of genes in gene set: 6984.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CDH13 0.0023649 169 GTEx DepMap Descartes 0.47 80.82
EFNB2 0.0017053 264 GTEx DepMap Descartes 0.42 108.37
CEACAM1 0.0006405 868 GTEx DepMap Descartes 0.08 30.90
TEK 0.0005756 962 GTEx DepMap Descartes 0.05 14.29
IRX3 0.0004247 1231 GTEx DepMap Descartes 0.01 4.60
EHD3 0.0002947 1611 GTEx DepMap Descartes 0.03 9.69
GALNT15 0.0001877 2093 GTEx DepMap Descartes 0.01 NA
F8 -0.0000644 4619 GTEx DepMap Descartes 0.00 0.24
CYP26B1 -0.0000694 4697 GTEx DepMap Descartes 0.01 1.57
CRHBP -0.0001279 5698 GTEx DepMap Descartes 0.00 2.28
TMEM88 -0.0001638 6272 GTEx DepMap Descartes 0.05 80.56
SHE -0.0001667 6324 GTEx DepMap Descartes 0.01 0.84
NOTCH4 -0.0001850 6599 GTEx DepMap Descartes 0.03 3.84
ROBO4 -0.0001856 6609 GTEx DepMap Descartes 0.01 1.80
KANK3 -0.0001934 6733 GTEx DepMap Descartes 0.01 3.58
TIE1 -0.0001977 6808 GTEx DepMap Descartes 0.01 2.00
BTNL9 -0.0002005 6858 GTEx DepMap Descartes 0.00 1.04
SLCO2A1 -0.0002023 6884 GTEx DepMap Descartes 0.01 2.23
RASIP1 -0.0002073 6970 GTEx DepMap Descartes 0.01 3.00
MMRN2 -0.0002090 6999 GTEx DepMap Descartes 0.01 1.44
CLDN5 -0.0002101 7017 GTEx DepMap Descartes 0.01 4.65
NPR1 -0.0002271 7282 GTEx DepMap Descartes 0.00 0.04
KDR -0.0002323 7371 GTEx DepMap Descartes 0.00 0.46
CDH5 -0.0002324 7373 GTEx DepMap Descartes 0.01 0.99
ESM1 -0.0002425 7527 GTEx DepMap Descartes 0.00 1.06
CALCRL -0.0002738 7976 GTEx DepMap Descartes 0.03 5.09
HYAL2 -0.0003149 8585 GTEx DepMap Descartes 0.04 12.94
FLT4 -0.0003432 8948 GTEx DepMap Descartes 0.00 0.20
SHANK3 -0.0003712 9290 GTEx DepMap Descartes 0.02 3.68
MYRIP -0.0004149 9765 GTEx DepMap Descartes 0.17 35.25


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8417.34
Median rank of genes in gene set: 9840.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FREM1 0.0015929 293 GTEx DepMap Descartes 0.32 40.31
PRICKLE1 0.0009127 618 GTEx DepMap Descartes 0.51 117.59
CDH11 0.0006569 849 GTEx DepMap Descartes 0.19 34.32
PAMR1 0.0002945 1613 GTEx DepMap Descartes 0.07 29.96
LRRC17 0.0002368 1859 GTEx DepMap Descartes 0.05 30.28
SCARA5 0.0000566 3119 GTEx DepMap Descartes 0.00 1.10
OGN 0.0000337 3348 GTEx DepMap Descartes 0.04 11.99
ABCA6 0.0000029 3695 GTEx DepMap Descartes 0.03 5.19
GAS2 -0.0000527 4448 GTEx DepMap Descartes 0.10 55.06
ELN -0.0001203 5554 GTEx DepMap Descartes 0.06 17.84
LAMC3 -0.0001484 6019 GTEx DepMap Descartes 0.01 1.58
PCDH18 -0.0001521 6066 GTEx DepMap Descartes 0.00 0.16
ADAMTS2 -0.0001606 6213 GTEx DepMap Descartes 0.08 13.93
RSPO3 -0.0002126 7051 GTEx DepMap Descartes 0.00 NA
ADAMTSL3 -0.0002929 8268 GTEx DepMap Descartes 0.03 4.00
ABCC9 -0.0003191 8639 GTEx DepMap Descartes 0.00 0.57
CLDN11 -0.0003420 8934 GTEx DepMap Descartes 0.12 47.80
LOX -0.0003518 9053 GTEx DepMap Descartes 0.00 0.37
GLI2 -0.0003641 9214 GTEx DepMap Descartes 0.01 1.03
ITGA11 -0.0003830 9423 GTEx DepMap Descartes 0.00 0.32
SFRP2 -0.0003939 9530 GTEx DepMap Descartes 0.00 0.26
EDNRA -0.0004212 9824 GTEx DepMap Descartes 0.01 2.66
CD248 -0.0004245 9857 GTEx DepMap Descartes 0.00 0.72
DKK2 -0.0004263 9872 GTEx DepMap Descartes 0.02 5.13
PDGFRA -0.0004774 10348 GTEx DepMap Descartes 0.00 0.21
COL27A1 -0.0005035 10542 GTEx DepMap Descartes 0.01 1.00
COL12A1 -0.0005047 10553 GTEx DepMap Descartes 0.01 0.81
IGFBP3 -0.0005135 10627 GTEx DepMap Descartes 0.01 3.02
PRRX1 -0.0005245 10703 GTEx DepMap Descartes 0.00 1.10
CCDC80 -0.0005377 10789 GTEx DepMap Descartes 0.01 0.63


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.09e-03
Mean rank of genes in gene set: 4723.32
Median rank of genes in gene set: 3031.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ROBO1 0.0066089 14 GTEx DepMap Descartes 5.38 976.27
AGBL4 0.0057700 25 GTEx DepMap Descartes 2.85 941.23
FAM155A 0.0048086 45 GTEx DepMap Descartes 9.53 1365.94
GRID2 0.0046215 48 GTEx DepMap Descartes 1.54 373.20
NTNG1 0.0039028 66 GTEx DepMap Descartes 1.57 428.02
CDH12 0.0036341 77 GTEx DepMap Descartes 0.38 116.20
KCTD16 0.0034751 87 GTEx DepMap Descartes 1.86 171.30
PACRG 0.0029522 117 GTEx DepMap Descartes 0.78 629.21
TENM1 0.0026767 139 GTEx DepMap Descartes 0.83 NA
KSR2 0.0025181 154 GTEx DepMap Descartes 0.71 50.28
SLC18A1 0.0018360 238 GTEx DepMap Descartes 0.37 172.91
MGAT4C 0.0017556 251 GTEx DepMap Descartes 0.60 31.10
SLC24A2 0.0013853 353 GTEx DepMap Descartes 0.11 13.74
CNTN3 0.0011313 494 GTEx DepMap Descartes 0.10 24.19
UNC80 0.0010412 536 GTEx DepMap Descartes 1.02 94.97
GCH1 0.0007236 771 GTEx DepMap Descartes 0.42 192.30
PCSK2 0.0006538 855 GTEx DepMap Descartes 0.32 92.65
TBX20 0.0005947 932 GTEx DepMap Descartes 0.19 135.17
SLC35F3 0.0001027 2665 GTEx DepMap Descartes 0.20 83.26
PCSK1N 0.0000291 3398 GTEx DepMap Descartes 1.60 1905.61
CHGB 0.0000277 3405 GTEx DepMap Descartes 1.45 771.96
GRM7 0.0000019 3709 GTEx DepMap Descartes 0.35 107.20
LAMA3 -0.0000501 4405 GTEx DepMap Descartes 0.09 10.45
TIAM1 -0.0000640 4616 GTEx DepMap Descartes 0.66 114.10
SORCS3 -0.0001632 6259 GTEx DepMap Descartes 0.02 3.77
DGKK -0.0001986 6822 GTEx DepMap Descartes 0.01 1.08
PENK -0.0002888 8194 GTEx DepMap Descartes 0.00 0.00
C1QL1 -0.0004740 10310 GTEx DepMap Descartes 0.07 62.79
SPOCK3 -0.0006082 11223 GTEx DepMap Descartes 0.19 85.30
GALNTL6 -0.0007266 11687 GTEx DepMap Descartes 0.39 119.66


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.24e-02
Mean rank of genes in gene set: 4766.14
Median rank of genes in gene set: 4136
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SOX6 0.0060181 22 GTEx DepMap Descartes 1.65 246.18
EPB41 0.0020108 218 GTEx DepMap Descartes 0.78 155.81
TFR2 0.0009320 598 GTEx DepMap Descartes 0.33 134.98
SNCA 0.0009281 602 GTEx DepMap Descartes 0.23 83.28
ANK1 0.0006565 851 GTEx DepMap Descartes 0.25 37.40
DENND4A 0.0005903 942 GTEx DepMap Descartes 0.73 107.92
ALAS2 0.0001958 2046 GTEx DepMap Descartes 0.00 0.14
TRAK2 0.0001854 2108 GTEx DepMap Descartes 0.15 29.47
MARCH3 0.0001327 2453 GTEx DepMap Descartes 0.18 NA
RGS6 0.0001183 2554 GTEx DepMap Descartes 0.02 5.22
SLC25A37 0.0000970 2720 GTEx DepMap Descartes 0.11 30.08
RHD 0.0000961 2732 GTEx DepMap Descartes 0.03 12.35
XPO7 0.0000012 3714 GTEx DepMap Descartes 0.25 60.88
TMCC2 -0.0000078 3826 GTEx DepMap Descartes 0.04 11.39
SPTB -0.0000309 4136 GTEx DepMap Descartes 0.07 7.76
SLC25A21 -0.0000368 4222 GTEx DepMap Descartes 0.01 2.57
CAT -0.0000468 4361 GTEx DepMap Descartes 0.07 41.44
FECH -0.0001384 5854 GTEx DepMap Descartes 0.07 11.98
SLC4A1 -0.0001604 6205 GTEx DepMap Descartes 0.00 0.44
TSPAN5 -0.0001639 6276 GTEx DepMap Descartes 0.66 197.84
GYPC -0.0002181 7141 GTEx DepMap Descartes 0.01 4.22
BLVRB -0.0002631 7822 GTEx DepMap Descartes 0.03 24.27
CPOX -0.0002869 8159 GTEx DepMap Descartes 0.03 13.22
ABCB10 -0.0002963 8311 GTEx DepMap Descartes 0.09 28.08
SELENBP1 -0.0003081 8480 GTEx DepMap Descartes 0.00 0.20
MICAL2 -0.0004254 9861 GTEx DepMap Descartes 0.02 3.11
SPECC1 -0.0004462 10067 GTEx DepMap Descartes 0.02 2.00
RAPGEF2 -0.0004721 10300 GTEx DepMap Descartes 0.47 70.98
GCLC -0.0007107 11637 GTEx DepMap Descartes 0.08 25.67
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10160.45
Median rank of genes in gene set: 11216.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FMN1 0.0016476 279 GTEx DepMap Descartes 1.88 184.09
CD163L1 0.0001994 2029 GTEx DepMap Descartes 0.27 75.57
HRH1 -0.0000512 4425 GTEx DepMap Descartes 0.04 11.66
WWP1 -0.0001787 6501 GTEx DepMap Descartes 0.18 45.05
SFMBT2 -0.0002418 7512 GTEx DepMap Descartes 0.18 28.53
FGL2 -0.0002531 7664 GTEx DepMap Descartes 0.01 2.47
CPVL -0.0002735 7969 GTEx DepMap Descartes 0.04 24.37
CTSS -0.0003009 8384 GTEx DepMap Descartes 0.05 15.47
ATP8B4 -0.0003337 8822 GTEx DepMap Descartes 0.03 7.00
MS4A4A -0.0003734 9313 GTEx DepMap Descartes 0.01 5.18
HCK -0.0004329 9935 GTEx DepMap Descartes 0.01 7.52
CYBB -0.0004518 10118 GTEx DepMap Descartes 0.01 2.42
FGD2 -0.0004678 10273 GTEx DepMap Descartes 0.01 2.20
CSF1R -0.0005014 10530 GTEx DepMap Descartes 0.01 3.33
CD163 -0.0005110 10610 GTEx DepMap Descartes 0.00 0.78
AXL -0.0005408 10807 GTEx DepMap Descartes 0.02 5.19
ADAP2 -0.0005525 10881 GTEx DepMap Descartes 0.04 15.34
CD14 -0.0005825 11081 GTEx DepMap Descartes 0.02 14.22
SPP1 -0.0006063 11208 GTEx DepMap Descartes 0.35 316.06
IFNGR1 -0.0006084 11225 GTEx DepMap Descartes 0.07 36.12
CTSC -0.0006571 11443 GTEx DepMap Descartes 0.02 3.68
SLCO2B1 -0.0006782 11512 GTEx DepMap Descartes 0.02 3.43
SLC1A3 -0.0007306 11701 GTEx DepMap Descartes 0.01 2.89
PTPRE -0.0007492 11745 GTEx DepMap Descartes 0.05 8.18
LGMN -0.0007649 11784 GTEx DepMap Descartes 0.06 34.16
MERTK -0.0007759 11822 GTEx DepMap Descartes 0.01 2.83
ITPR2 -0.0008440 11975 GTEx DepMap Descartes 0.13 12.31
RBPJ -0.0008545 12001 GTEx DepMap Descartes 0.48 99.30
TGFBI -0.0008993 12070 GTEx DepMap Descartes 0.02 3.44
MSR1 -0.0009494 12152 GTEx DepMap Descartes 0.02 5.03


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.06e-01
Mean rank of genes in gene set: 5827.02
Median rank of genes in gene set: 5468
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LRRTM4 0.0090314 4 GTEx DepMap Descartes 6.03 2347.41
NRXN1 0.0044759 51 GTEx DepMap Descartes 3.48 476.71
PPP2R2B 0.0026986 137 GTEx DepMap Descartes 1.51 180.78
DST 0.0021884 189 GTEx DepMap Descartes 3.05 176.15
SORCS1 0.0020137 217 GTEx DepMap Descartes 1.81 325.43
TRPM3 0.0018513 235 GTEx DepMap Descartes 0.33 39.22
SOX5 0.0016890 270 GTEx DepMap Descartes 0.99 183.10
LAMA4 0.0016193 286 GTEx DepMap Descartes 0.15 26.35
SCN7A 0.0013697 360 GTEx DepMap Descartes 0.42 74.41
GFRA3 0.0012402 428 GTEx DepMap Descartes 0.26 167.56
XKR4 0.0011964 447 GTEx DepMap Descartes 0.37 23.13
PMP22 0.0011673 470 GTEx DepMap Descartes 0.55 389.20
IL1RAPL1 0.0008760 641 GTEx DepMap Descartes 0.35 115.75
PAG1 0.0006882 815 GTEx DepMap Descartes 0.74 82.91
NRXN3 0.0006316 877 GTEx DepMap Descartes 0.36 56.64
COL25A1 0.0005265 1039 GTEx DepMap Descartes 0.06 9.06
ADAMTS5 0.0002600 1764 GTEx DepMap Descartes 0.02 2.53
SLC35F1 0.0000737 2954 GTEx DepMap Descartes 0.08 17.96
PTN -0.0000155 3910 GTEx DepMap Descartes 0.27 203.45
EGFLAM -0.0000613 4579 GTEx DepMap Descartes 0.15 37.77
GRIK3 -0.0000999 5219 GTEx DepMap Descartes 0.04 4.43
HMGA2 -0.0001120 5432 GTEx DepMap Descartes 0.00 0.81
MDGA2 -0.0001168 5504 GTEx DepMap Descartes 0.00 0.86
PLP1 -0.0001207 5564 GTEx DepMap Descartes 0.00 1.17
MPZ -0.0001634 6265 GTEx DepMap Descartes 0.01 5.64
ERBB3 -0.0002216 7206 GTEx DepMap Descartes 0.01 2.08
EDNRB -0.0002822 8096 GTEx DepMap Descartes 0.00 0.50
OLFML2A -0.0003469 8993 GTEx DepMap Descartes 0.00 0.37
PTPRZ1 -0.0003604 9161 GTEx DepMap Descartes 0.01 0.87
SFRP1 -0.0005050 10559 GTEx DepMap Descartes 0.06 15.00


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 7316.49
Median rank of genes in gene set: 7012
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMSB4X 0.0027689 134 GTEx DepMap Descartes 6.00 4689.67
INPP4B 0.0025878 147 GTEx DepMap Descartes 1.07 162.41
RAB27B 0.0011492 480 GTEx DepMap Descartes 0.18 33.11
STON2 0.0011368 488 GTEx DepMap Descartes 0.18 53.34
DOK6 0.0008042 687 GTEx DepMap Descartes 0.39 56.56
ITGA2B 0.0007046 800 GTEx DepMap Descartes 0.11 41.59
CD9 0.0003739 1355 GTEx DepMap Descartes 0.23 158.69
TUBB1 0.0001424 2383 GTEx DepMap Descartes 0.00 0.92
TLN1 0.0000874 2811 GTEx DepMap Descartes 0.11 16.95
TGFB1 -0.0000418 4295 GTEx DepMap Descartes 0.13 63.16
PRKAR2B -0.0000550 4484 GTEx DepMap Descartes 0.40 142.40
P2RX1 -0.0000653 4631 GTEx DepMap Descartes 0.00 2.30
SLC24A3 -0.0001160 5490 GTEx DepMap Descartes 0.07 19.17
MYLK -0.0001288 5711 GTEx DepMap Descartes 0.03 3.88
ACTN1 -0.0001306 5743 GTEx DepMap Descartes 0.29 76.73
ITGB3 -0.0001370 5833 GTEx DepMap Descartes 0.00 0.00
MMRN1 -0.0001399 5876 GTEx DepMap Descartes 0.00 0.60
GP1BA -0.0001405 5894 GTEx DepMap Descartes 0.02 7.87
RAP1B -0.0001578 6162 GTEx DepMap Descartes 0.20 19.65
PSTPIP2 -0.0001772 6471 GTEx DepMap Descartes 0.02 8.67
ARHGAP6 -0.0001878 6650 GTEx DepMap Descartes 0.02 3.16
ANGPT1 -0.0002029 6892 GTEx DepMap Descartes 0.01 3.10
UBASH3B -0.0002097 7012 GTEx DepMap Descartes 0.07 12.36
TRPC6 -0.0002228 7224 GTEx DepMap Descartes 0.01 1.47
VCL -0.0002742 7980 GTEx DepMap Descartes 0.11 17.04
FERMT3 -0.0002959 8304 GTEx DepMap Descartes 0.02 7.85
SPN -0.0003088 8494 GTEx DepMap Descartes 0.01 1.36
PLEK -0.0004257 9864 GTEx DepMap Descartes 0.01 3.93
CD84 -0.0004650 10251 GTEx DepMap Descartes 0.01 1.62
LTBP1 -0.0004763 10339 GTEx DepMap Descartes 0.02 4.09


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.02e-01
Mean rank of genes in gene set: 6136.21
Median rank of genes in gene set: 6097.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RAP1GAP2 0.0035586 82 GTEx DepMap Descartes 2.06 406.87
STK39 0.0026238 142 GTEx DepMap Descartes 1.29 515.49
NCALD 0.0014413 329 GTEx DepMap Descartes 0.39 132.42
CD44 0.0014306 332 GTEx DepMap Descartes 1.08 259.52
FYN 0.0012662 417 GTEx DepMap Descartes 1.40 492.47
FOXP1 0.0011448 484 GTEx DepMap Descartes 1.83 252.43
SORL1 0.0011353 490 GTEx DepMap Descartes 0.40 46.13
TOX 0.0009243 607 GTEx DepMap Descartes 1.37 438.94
SCML4 0.0009108 620 GTEx DepMap Descartes 0.31 86.89
PITPNC1 0.0008461 661 GTEx DepMap Descartes 1.03 200.46
CELF2 0.0008239 675 GTEx DepMap Descartes 0.35 56.17
BCL2 0.0007421 745 GTEx DepMap Descartes 2.43 408.62
MCTP2 0.0004317 1217 GTEx DepMap Descartes 0.06 9.05
GNG2 0.0002309 1883 GTEx DepMap Descartes 0.65 223.15
ABLIM1 0.0000781 2897 GTEx DepMap Descartes 0.25 39.95
CCL5 0.0000460 3208 GTEx DepMap Descartes 0.02 21.18
LCP1 -0.0000985 5183 GTEx DepMap Descartes 0.04 12.15
BACH2 -0.0001064 5346 GTEx DepMap Descartes 0.70 97.82
LEF1 -0.0001211 5575 GTEx DepMap Descartes 0.02 7.74
DOCK10 -0.0001249 5641 GTEx DepMap Descartes 0.45 73.93
EVL -0.0001255 5652 GTEx DepMap Descartes 1.11 372.47
SKAP1 -0.0001816 6543 GTEx DepMap Descartes 0.06 40.43
SAMD3 -0.0001955 6767 GTEx DepMap Descartes 0.02 6.15
ARHGDIB -0.0001999 6838 GTEx DepMap Descartes 0.01 11.71
PDE3B -0.0003077 8477 GTEx DepMap Descartes 0.36 74.56
ANKRD44 -0.0003445 8965 GTEx DepMap Descartes 0.31 53.24
RCSD1 -0.0004062 9678 GTEx DepMap Descartes 0.02 3.38
ETS1 -0.0004310 9912 GTEx DepMap Descartes 0.03 7.45
PRKCH -0.0004351 9957 GTEx DepMap Descartes 0.05 14.06
PTPRC -0.0004660 10262 GTEx DepMap Descartes 0.04 9.26


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-02
Mean rank of genes in gene set: 1840
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ITGA2B 0.0007046 800 GTEx DepMap Descartes 0.11 41.59
GATA2 0.0000794 2880 GTEx DepMap Descartes 0.42 168.69


Megakaryocyte precursor: Megakaryocyte precursor (curated markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.77e-02
Mean rank of genes in gene set: 2242.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRSS57 0.0002962 1605 GTEx DepMap Descartes 0.01 8.22
GATA2 0.0000794 2880 GTEx DepMap Descartes 0.42 168.69


B-cell lineage: Large pre-B cells (model markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.00e-02
Mean rank of genes in gene set: 641
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IL1RAPL1 0.000876 641 GTEx DepMap Descartes 0.35 115.75