Program: 17. Cancer Associated Fibroblast: Myofibroblast (Contractile).

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QQ-plot of gene loadings, averaged over both independent splits of the data
This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program. Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret. The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program (currently only calculated for the cells in the first 50/50 split of the data). Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

	Gene	Loading	Gene.Name	GTEx	DepMap	Descartes	Mean.Counts	Mean.Tpm
1	NOTCH3	0.0119134	notch receptor 3	GTEx	DepMap	Descartes	10.02	306.67
2	RGS5	0.0102950	regulator of G protein signaling 5	GTEx	DepMap	Descartes	44.82	1941.28
3	ACTA2	0.0102396	actin alpha 2, smooth muscle	GTEx	DepMap	Descartes	25.28	4742.88
4	ADAMTS4	0.0099806	ADAM metallopeptidase with thrombospondin type 1 motif 4	GTEx	DepMap	Descartes	13.12	393.75
5	MYL9	0.0098854	myosin light chain 9	GTEx	DepMap	Descartes	11.53	1057.80
6	MYH11	0.0098162	myosin heavy chain 11	GTEx	DepMap	Descartes	5.78	253.83
7	MYLK	0.0098068	myosin light chain kinase	GTEx	DepMap	Descartes	6.17	154.64
8	CALD1	0.0085909	caldesmon 1	GTEx	DepMap	Descartes	14.98	735.14
9	TPM2	0.0081341	tropomyosin 2	GTEx	DepMap	Descartes	6.11	1005.19
10	MCAM	0.0079638	melanoma cell adhesion molecule	GTEx	DepMap	Descartes	6.16	326.77
11	TAGLN	0.0076236	transgelin	GTEx	DepMap	Descartes	21.69	1517.90
12	EPAS1	0.0075363	endothelial PAS domain protein 1	GTEx	DepMap	Descartes	14.05	687.17
13	COL18A1	0.0071299	collagen type XVIII alpha 1 chain	GTEx	DepMap	Descartes	8.32	294.98
14	ENPEP	0.0071229	glutamyl aminopeptidase	GTEx	DepMap	Descartes	1.70	62.52
15	ADAMTS1	0.0070995	ADAM metallopeptidase with thrombospondin type 1 motif 1	GTEx	DepMap	Descartes	10.30	542.44
16	COL4A1	0.0070518	collagen type IV alpha 1 chain	GTEx	DepMap	Descartes	16.86	540.87
17	GUCY1A2	0.0068754	guanylate cyclase 1 soluble subunit alpha 2	GTEx	DepMap	Descartes	1.65	26.30
18	CD36	0.0068212	CD36 molecule	GTEx	DepMap	Descartes	2.59	103.82
19	PDK4	0.0067527	pyruvate dehydrogenase kinase 4	GTEx	DepMap	Descartes	6.48	528.61
20	COL4A2	0.0067010	collagen type IV alpha 2 chain	GTEx	DepMap	Descartes	21.16	681.46
21	NDUFA4L2	0.0066761	NDUFA4 mitochondrial complex associated like 2	GTEx	DepMap	Descartes	1.69	349.08
22	SYNPO2	0.0066564	synaptopodin 2	GTEx	DepMap	Descartes	3.30	62.60
23	PDGFRB	0.0065880	platelet derived growth factor receptor beta	GTEx	DepMap	Descartes	6.22	279.77
24	TPM1	0.0065753	tropomyosin 1	GTEx	DepMap	Descartes	7.28	442.76
25	PARM1	0.0064975	prostate androgen-regulated mucin-like protein 1	GTEx	DepMap	Descartes	1.45	77.21
26	EFHD1	0.0063630	EF-hand domain family member D1	GTEx	DepMap	Descartes	1.49	194.01
27	LMOD1	0.0063396	leiomodin 1	GTEx	DepMap	Descartes	1.17	87.15
28	LPP	0.0062298	LIM domain containing preferred translocation partner in lipoma	GTEx	DepMap	Descartes	7.26	102.73
29	STEAP4	0.0062069	STEAP4 metalloreductase	GTEx	DepMap	Descartes	2.75	76.43
30	ACTG2	0.0061135	actin gamma 2, smooth muscle	GTEx	DepMap	Descartes	2.13	286.53
31	FILIP1L	0.0060749	filamin A interacting protein 1 like	GTEx	DepMap	Descartes	5.32	347.43
32	RNF152	0.0060614	ring finger protein 152	GTEx	DepMap	Descartes	1.60	50.20
33	PLN	0.0060141	phospholamban	GTEx	DepMap	Descartes	0.91	97.56
34	TINAGL1	0.0059821	tubulointerstitial nephritis antigen like 1	GTEx	DepMap	Descartes	2.44	124.27
35	AOC3	0.0058195	amine oxidase copper containing 3	GTEx	DepMap	Descartes	1.33	93.60
36	ABCC9	0.0057510	ATP binding cassette subfamily C member 9	GTEx	DepMap	Descartes	2.17	71.55
37	MRVI1	0.0057452	NA	GTEx	DepMap	Descartes	0.92	40.17
38	CPE	0.0057214	carboxypeptidase E	GTEx	DepMap	Descartes	6.61	662.63
39	MFGE8	0.0055828	milk fat globule EGF and factor V/VIII domain containing	GTEx	DepMap	Descartes	3.23	326.08
40	DSTN	0.0055050	destrin, actin depolymerizing factor	GTEx	DepMap	Descartes	6.31	478.09
41	IGFBP7	0.0054871	insulin like growth factor binding protein 7	GTEx	DepMap	Descartes	90.37	14869.03
42	SLC7A2	0.0054080	solute carrier family 7 member 2	GTEx	DepMap	Descartes	2.14	66.85
43	CRISPLD2	0.0053907	cysteine rich secretory protein LCCL domain containing 2	GTEx	DepMap	Descartes	7.85	486.49
44	CSPG4	0.0053302	chondroitin sulfate proteoglycan 4	GTEx	DepMap	Descartes	0.76	23.58
45	EDNRB	0.0053267	endothelin receptor type B	GTEx	DepMap	Descartes	2.52	128.06
46	RASD2	0.0052760	RASD family member 2	GTEx	DepMap	Descartes	0.56	36.86
47	ITGA1	0.0051875	integrin subunit alpha 1	GTEx	DepMap	Descartes	5.40	111.58
48	RCAN2	0.0051364	regulator of calcineurin 2	GTEx	DepMap	Descartes	1.27	113.93
49	TNS1	0.0051181	tensin 1	GTEx	DepMap	Descartes	4.67	114.91
50	LDB3	0.0051113	LIM domain binding 3	GTEx	DepMap	Descartes	0.32	17.05

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UMAP plots showing activity of gene expression program identified in community:17. Cancer Associated Fibroblast: Myofibroblast (Contractile)

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 17. Cancer Associated Fibroblast: Myofibroblast (Contractile):

Interactive Boxplot

CNV Data procured from inferCNV.
Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
The top cells expressing this GEP (purple)
Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes

mSigDB Cell Types Gene Set:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_VASCULAR_SMOOTH_MUSCLE_CELLS	6.37e-51	268.06	139.77	4.28e-48	4.28e-48	29NOTCH3, RGS5, ACTA2, MYL9, MYH11, MYLK, CALD1, TPM2, MCAM, TAGLN, ADAMTS1, NDUFA4L2, SYNPO2, PDGFRB, TPM1, EFHD1, LMOD1, LPP, STEAP4, ACTG2, FILIP1L, PLN, TINAGL1, MFGE8, DSTN, IGFBP7, CRISPLD2, RCAN2, TNS1	93
TRAVAGLINI_LUNG_VASCULAR_SMOOTH_MUSCLE_CELL	6.40e-35	201.92	100.42	2.15e-32	4.29e-32	20NOTCH3, RGS5, ACTA2, MYL9, MYLK, CALD1, TPM2, MCAM, TAGLN, EPAS1, TPM1, PARM1, EFHD1, LMOD1, LPP, ACTG2, TINAGL1, IGFBP7, ITGA1, RCAN2	61
DESCARTES_MAIN_FETAL_SMOOTH_MUSCLE_CELLS	8.28e-18	106.68	45.15	3.97e-16	5.55e-15	11NOTCH3, ACTA2, MYH11, MYLK, TAGLN, NDUFA4L2, PDGFRB, ACTG2, AOC3, ABCC9, CSPG4	44
AIZARANI_LIVER_C33_STELLATE_CELLS_2	8.21e-30	86.04	45.07	1.84e-27	5.51e-27	21NOTCH3, RGS5, ACTA2, MYL9, MYH11, MYLK, CALD1, TPM2, MCAM, EPAS1, ADAMTS1, COL4A1, COL4A2, TPM1, LPP, CPE, IGFBP7, CRISPLD2, ITGA1, RCAN2, TNS1	126
DESCARTES_FETAL_HEART_SMOOTH_MUSCLE_CELLS	1.09e-17	103.00	43.97	4.88e-16	7.32e-15	11NOTCH3, ACTA2, MYH11, TAGLN, ENPEP, NDUFA4L2, PDGFRB, LMOD1, ACTG2, AOC3, ABCC9	45
DESCARTES_FETAL_INTESTINE_SMOOTH_MUSCLE_CELLS	3.94e-17	90.17	38.70	1.65e-15	2.65e-14	11RGS5, ACTA2, MYL9, MYH11, MYLK, TAGLN, LMOD1, ACTG2, AOC3, DSTN, LDB3	50
RUBENSTEIN_SKELETAL_MUSCLE_PERICYTES	1.60e-28	73.54	38.65	2.14e-26	1.07e-25	21NOTCH3, RGS5, ACTA2, MYL9, CALD1, TPM2, MCAM, TAGLN, COL4A1, CD36, COL4A2, NDUFA4L2, PDGFRB, TPM1, EFHD1, STEAP4, TINAGL1, ABCC9, CPE, MFGE8, IGFBP7	144
DESCARTES_FETAL_MUSCLE_SMOOTH_MUSCLE_CELLS	2.71e-20	75.75	35.96	1.40e-18	1.82e-17	14RGS5, ACTA2, MYH11, TAGLN, ENPEP, GUCY1A2, NDUFA4L2, PDGFRB, STEAP4, ACTG2, PLN, AOC3, ABCC9, RCAN2	78
TRAVAGLINI_LUNG_AIRWAY_SMOOTH_MUSCLE_CELL	3.59e-27	62.35	32.96	3.44e-25	2.41e-24	21ACTA2, MYL9, MYH11, MYLK, TPM2, MCAM, TAGLN, EPAS1, SYNPO2, TPM1, EFHD1, LMOD1, LPP, ACTG2, PLN, TINAGL1, DSTN, IGFBP7, EDNRB, RCAN2, LDB3	166
DESCARTES_FETAL_PANCREAS_SMOOTH_MUSCLE_CELLS	1.54e-12	79.05	29.59	5.17e-11	1.03e-09	8RGS5, ACTA2, MYH11, NDUFA4L2, ACTG2, PLN, AOC3, CSPG4	38
FAN_OVARY_CL17_PUTATIVE_APOPTOTIC_SMOOTH_MUSCLE_CELL	1.90e-27	51.18	27.52	2.12e-25	1.27e-24	23RGS5, ACTA2, ADAMTS4, MYL9, MYH11, MYLK, TPM2, TAGLN, EPAS1, COL18A1, ADAMTS1, COL4A1, PDK4, NDUFA4L2, PDGFRB, TPM1, EFHD1, TINAGL1, CPE, MFGE8, DSTN, IGFBP7, CRISPLD2	231
FAN_OVARY_CL14_MATURE_SMOOTH_MUSCLE_CELL	1.56e-29	48.38	26.33	2.61e-27	1.05e-26	26NOTCH3, RGS5, ACTA2, MYL9, MYH11, MYLK, CALD1, TPM2, MCAM, TAGLN, EPAS1, COL18A1, ADAMTS1, PDK4, NDUFA4L2, TPM1, EFHD1, LMOD1, PLN, TINAGL1, AOC3, CPE, MFGE8, DSTN, IGFBP7, RCAN2	306
LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES	8.38e-21	46.61	23.76	4.69e-19	5.62e-18	17ACTA2, MYH11, MYLK, CALD1, MCAM, TAGLN, EPAS1, COL18A1, COL4A1, COL4A2, SYNPO2, TPM1, LPP, DSTN, ITGA1, RCAN2, TNS1	155
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2	3.58e-23	34.92	18.80	2.40e-21	2.40e-20	22NOTCH3, RGS5, MYL9, MYLK, CALD1, TPM2, MCAM, TAGLN, EPAS1, COL18A1, COL4A1, GUCY1A2, COL4A2, NDUFA4L2, PDGFRB, ABCC9, CPE, MFGE8, IGFBP7, CSPG4, ITGA1, TNS1	303
RUBENSTEIN_SKELETAL_MUSCLE_SMOOTH_MUSCLE_CELLS	2.20e-25	32.34	17.68	1.64e-23	1.48e-22	26NOTCH3, RGS5, ACTA2, MYL9, MYH11, MYLK, CALD1, TPM2, MCAM, TAGLN, NDUFA4L2, SYNPO2, TPM1, EFHD1, LMOD1, LPP, ACTG2, FILIP1L, PLN, TINAGL1, CPE, MFGE8, DSTN, IGFBP7, RCAN2, TNS1	445
GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS	1.75e-25	30.73	16.83	1.46e-23	1.17e-22	27NOTCH3, RGS5, ACTA2, MYL9, CALD1, TPM2, MCAM, COL18A1, ADAMTS1, COL4A1, CD36, COL4A2, NDUFA4L2, SYNPO2, PDGFRB, LMOD1, STEAP4, FILIP1L, AOC3, MFGE8, IGFBP7, SLC7A2, CRISPLD2, CSPG4, EDNRB, ITGA1, TNS1	505
AIZARANI_LIVER_C21_STELLATE_CELLS_1	4.48e-16	29.91	14.90	1.77e-14	3.00e-13	15ACTA2, MYL9, MYLK, CALD1, EPAS1, ADAMTS1, COL4A1, COL4A2, SYNPO2, FILIP1L, DSTN, IGFBP7, CRISPLD2, EDNRB, TNS1	194
TRAVAGLINI_LUNG_PERICYTE_CELL	1.78e-11	30.02	13.03	5.43e-10	1.19e-08	10NOTCH3, RGS5, MCAM, COL4A1, GUCY1A2, COL4A2, NDUFA4L2, PDGFRB, CSPG4, ITGA1	114
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS	9.58e-10	32.13	12.59	2.57e-08	6.43e-07	8ACTA2, CALD1, TPM2, TAGLN, SYNPO2, TPM1, CPE, IGFBP7	82
MANNO_MIDBRAIN_NEUROTYPES_HPERIC	8.07e-22	20.78	11.40	4.93e-20	5.42e-19	28NOTCH3, RGS5, ACTA2, ADAMTS4, MYL9, MYLK, CALD1, TPM2, MCAM, TAGLN, EPAS1, COL18A1, ENPEP, ADAMTS1, COL4A1, GUCY1A2, COL4A2, NDUFA4L2, PDGFRB, LPP, FILIP1L, ABCC9, MFGE8, IGFBP7, CRISPLD2, CSPG4, ITGA1, TNS1	795

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mSigDB Hallmark Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	4.29e-09	16.45	7.22	2.15e-07	2.15e-07	10ACTA2, MYL9, MYLK, CALD1, TPM2, TAGLN, COL4A1, COL4A2, PDGFRB, TPM1	200
HALLMARK_MYOGENESIS	9.73e-07	12.40	4.96	2.43e-05	4.87e-05	8MYH11, MYLK, TPM2, TAGLN, CD36, COL4A2, IGFBP7, LDB3	200
HALLMARK_ADIPOGENESIS	4.35e-02	4.05	0.80	5.44e-01	1.00e+00	3MYLK, COL4A1, CD36	200
HALLMARK_XENOBIOTIC_METABOLISM	4.35e-02	4.05	0.80	5.44e-01	1.00e+00	3ENPEP, CD36, PDK4	200
HALLMARK_ANDROGEN_RESPONSE	5.93e-02	5.31	0.62	5.93e-01	1.00e+00	2ADAMTS1, STEAP4	100
HALLMARK_FATTY_ACID_METABOLISM	1.28e-01	3.34	0.39	9.15e-01	1.00e+00	2CD36, AOC3	158
HALLMARK_APICAL_JUNCTION	1.85e-01	2.63	0.31	1.00e+00	1.00e+00	2MYL9, ACTG2	200
HALLMARK_COMPLEMENT	1.85e-01	2.63	0.31	1.00e+00	1.00e+00	2CD36, COL4A2	200
HALLMARK_NOTCH_SIGNALING	1.20e-01	8.23	0.20	9.15e-01	1.00e+00	1NOTCH3	32
HALLMARK_IL6_JAK_STAT3_SIGNALING	2.93e-01	2.97	0.07	1.00e+00	1.00e+00	1CD36	87
HALLMARK_UV_RESPONSE_DN	4.35e-01	1.78	0.04	1.00e+00	1.00e+00	1PDGFRB	144
HALLMARK_APOPTOSIS	4.72e-01	1.59	0.04	1.00e+00	1.00e+00	1PDGFRB	161
HALLMARK_ESTROGEN_RESPONSE_EARLY	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1SLC7A2	200
HALLMARK_ESTROGEN_RESPONSE_LATE	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1CPE	200
HALLMARK_INFLAMMATORY_RESPONSE	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1SLC7A2	200
HALLMARK_OXIDATIVE_PHOSPHORYLATION	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1PDK4	200
HALLMARK_HEME_METABOLISM	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1TNS1	200
HALLMARK_KRAS_SIGNALING_UP	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1CPE	200
HALLMARK_KRAS_SIGNALING_DN	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1EFHD1	200
HALLMARK_TNFA_SIGNALING_VIA_NFKB	1.00e+00	0.00	0.00	1.00e+00	1.00e+00	0	200

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KEGG Pathways:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	3.07e-07	18.82	6.99	5.70e-05	5.70e-05	7ACTA2, MYL9, MYH11, MYLK, CALD1, GUCY1A2, ACTG2	115
KEGG_ECM_RECEPTOR_INTERACTION	3.32e-04	13.58	3.47	2.00e-02	6.17e-02	4COL4A1, CD36, COL4A2, ITGA1	84
KEGG_DILATED_CARDIOMYOPATHY	4.31e-04	12.63	3.23	2.00e-02	8.02e-02	4TPM2, TPM1, PLN, ITGA1	90
KEGG_FOCAL_ADHESION	1.20e-04	8.83	3.04	1.12e-02	2.24e-02	6MYL9, MYLK, COL4A1, COL4A2, PDGFRB, ITGA1	199
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	4.29e-03	9.97	1.94	1.60e-01	7.98e-01	3TPM2, TPM1, ITGA1	83
KEGG_CALCIUM_SIGNALING_PATHWAY	5.16e-03	6.25	1.62	1.60e-01	9.60e-01	4MYLK, PDGFRB, PLN, EDNRB	178
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	9.54e-03	5.20	1.35	2.54e-01	1.00e+00	4MYL9, MYLK, PDGFRB, ITGA1	213
KEGG_PATHWAYS_IN_CANCER	3.70e-02	3.39	0.88	7.64e-01	1.00e+00	4EPAS1, COL4A1, COL4A2, PDGFRB	325
KEGG_CARDIAC_MUSCLE_CONTRACTION	3.90e-02	6.76	0.78	7.64e-01	1.00e+00	2TPM2, TPM1	79
KEGG_SMALL_CELL_LUNG_CANCER	4.36e-02	6.35	0.74	7.64e-01	1.00e+00	2COL4A1, COL4A2	84
KEGG_HEMATOPOIETIC_CELL_LINEAGE	4.64e-02	6.13	0.71	7.64e-01	1.00e+00	2CD36, ITGA1	87
KEGG_GAP_JUNCTION	4.93e-02	5.92	0.69	7.64e-01	1.00e+00	2GUCY1A2, PDGFRB	90
KEGG_TIGHT_JUNCTION	9.54e-02	4.01	0.47	1.00e+00	1.00e+00	2MYL9, MYH11	132
KEGG_RENIN_ANGIOTENSIN_SYSTEM	6.56e-02	15.93	0.37	9.21e-01	1.00e+00	1ENPEP	17
KEGG_PHENYLALANINE_METABOLISM	6.93e-02	14.99	0.35	9.21e-01	1.00e+00	1AOC3	18
KEGG_BETA_ALANINE_METABOLISM	8.40e-02	12.14	0.29	1.00e+00	1.00e+00	1AOC3	22
KEGG_DORSO_VENTRAL_AXIS_FORMATION	9.13e-02	11.08	0.26	1.00e+00	1.00e+00	1NOTCH3	24
KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM	1.16e-01	8.50	0.20	1.00e+00	1.00e+00	1AOC3	31
KEGG_TYROSINE_METABOLISM	1.54e-01	6.22	0.15	1.00e+00	1.00e+00	1AOC3	42
KEGG_TYPE_I_DIABETES_MELLITUS	1.57e-01	6.07	0.15	1.00e+00	1.00e+00	1CPE	43

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CHR Positional Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
chr7q21	2.65e-02	4.95	0.98	1.00e+00	1.00e+00	3CD36, PDK4, STEAP4	164
chr10q23	1.71e-01	2.77	0.32	1.00e+00	1.00e+00	2ACTA2, LDB3	190
chr11q23	1.92e-01	2.57	0.30	1.00e+00	1.00e+00	2MCAM, TAGLN	205
chr1q23	2.09e-01	2.42	0.28	1.00e+00	1.00e+00	2RGS5, ADAMTS4	217
chr8p22	1.64e-01	5.80	0.14	1.00e+00	1.00e+00	1SLC7A2	45
chr3q12	1.67e-01	5.67	0.14	1.00e+00	1.00e+00	1FILIP1L	46
chr7q33	1.87e-01	5.00	0.12	1.00e+00	1.00e+00	1CALD1	52
chr4q26	1.90e-01	4.91	0.12	1.00e+00	1.00e+00	1SYNPO2	53
chr13q22	2.16e-01	4.25	0.10	1.00e+00	1.00e+00	1EDNRB	61
chr4q12	2.70e-01	3.27	0.08	1.00e+00	1.00e+00	1IGFBP7	79
chr2p21	2.73e-01	3.23	0.08	1.00e+00	1.00e+00	1EPAS1	80
chr5q11	2.87e-01	3.04	0.07	1.00e+00	1.00e+00	1ITGA1	85
chr4q25	2.93e-01	2.97	0.07	1.00e+00	1.00e+00	1ENPEP	87
chr11q22	3.23e-01	2.63	0.06	1.00e+00	1.00e+00	1GUCY1A2	98
chr20p12	3.39e-01	2.48	0.06	1.00e+00	1.00e+00	1DSTN	104
chr12p12	3.46e-01	2.41	0.06	1.00e+00	1.00e+00	1ABCC9	107
chr4q32	3.62e-01	2.28	0.06	1.00e+00	1.00e+00	1CPE	113
chr3q27	3.67e-01	2.24	0.06	1.00e+00	1.00e+00	1LPP	115
chr15q24	3.69e-01	2.22	0.05	1.00e+00	1.00e+00	1CSPG4	116
chr21q21	3.77e-01	2.16	0.05	1.00e+00	1.00e+00	1ADAMTS1	119

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Transcription Factor Targets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
SRF_C	5.32e-14	24.17	11.85	6.03e-11	6.03e-11	14MYL9, MYH11, MYLK, CALD1, MCAM, TAGLN, EFHD1, LPP, ACTG2, PLN, AOC3, DSTN, RASD2, LDB3	215
CCAWWNAAGG_SRF_Q4	4.88e-08	25.08	9.25	1.11e-05	5.53e-05	7MYH11, MYLK, CALD1, TPM2, TAGLN, ACTG2, PLN	88
SRF_Q4	5.76e-11	18.11	8.49	3.26e-08	6.53e-08	12MYL9, MYH11, MYLK, CALD1, TPM2, TAGLN, TPM1, EFHD1, LPP, ACTG2, DSTN, RASD2	230
SRF_Q6	1.36e-10	16.73	7.85	5.14e-08	1.54e-07	12MYL9, MYH11, MYLK, CALD1, TPM2, TAGLN, EFHD1, LPP, ACTG2, PLN, RASD2, LDB3	248
SRF_Q5_01	8.10e-10	16.47	7.50	2.30e-07	9.18e-07	11MYL9, MYH11, MYLK, CALD1, TPM2, TAGLN, EFHD1, LPP, ACTG2, PLN, DSTN	225
SRF_01	4.78e-05	23.08	5.81	9.02e-03	5.41e-02	4MYH11, CALD1, TPM1, ACTG2	51
TATA_C	7.96e-04	6.11	2.11	1.13e-01	9.01e-01	6MYH11, MYLK, TAGLN, EPAS1, PDGFRB, LMOD1	285
TGGAAA_NFAT_Q4_01	1.59e-04	3.36	1.75	2.57e-02	1.80e-01	17ADAMTS4, CALD1, TPM2, MCAM, PDK4, TPM1, EFHD1, LMOD1, RNF152, TINAGL1, CPE, DSTN, IGFBP7, CSPG4, RCAN2, TNS1, LDB3	1934
YY1_01	2.92e-03	5.62	1.73	2.70e-01	1.00e+00	5MYH11, CALD1, TPM1, ACTG2, DSTN	252
SMAD_Q6	3.23e-03	5.49	1.69	2.70e-01	1.00e+00	5NOTCH3, CALD1, TAGLN, RNF152, TINAGL1	258
PPARA_01	9.43e-03	14.87	1.69	5.48e-01	1.00e+00	2CD36, TNS1	37
AP1_Q6	3.28e-03	5.47	1.68	2.70e-01	1.00e+00	5PDGFRB, LPP, TINAGL1, DSTN, RCAN2	259
TGACATY_UNKNOWN	3.57e-03	3.57	1.44	2.70e-01	1.00e+00	8MYLK, CALD1, MCAM, TAGLN, PDK4, LPP, STEAP4, RCAN2	676
MEF2_03	1.42e-02	4.61	1.19	5.48e-01	1.00e+00	4MYLK, TPM2, EFHD1, MFGE8	240
CTTTAAR_UNKNOWN	9.72e-03	2.79	1.19	5.48e-01	1.00e+00	9TAGLN, EPAS1, EFHD1, LMOD1, ACTG2, MFGE8, CSPG4, ITGA1, LDB3	994
SMAD4_Q6	1.50e-02	4.53	1.17	5.48e-01	1.00e+00	4NOTCH3, ADAMTS4, MYLK, CALD1	244
ZNF92_TARGET_GENES	1.57e-02	2.47	1.14	5.48e-01	1.00e+00	11ACTA2, MYLK, CALD1, TAGLN, PDGFRB, LPP, FILIP1L, TINAGL1, CRISPLD2, ITGA1, TNS1	1440
P53_02	1.73e-02	4.33	1.12	5.48e-01	1.00e+00	4ADAMTS4, MYH11, CALD1, LPP	255
TFIIA_Q6	1.75e-02	4.31	1.12	5.48e-01	1.00e+00	4MYH11, ACTG2, CSPG4, ITGA1	256
P53_DECAMER_Q2	1.80e-02	4.28	1.11	5.48e-01	1.00e+00	4ADAMTS4, MYH11, EFHD1, LDB3	258

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GO Biological Processes:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GOBP_MESENCHYME_MIGRATION	1.54e-04	172.68	14.09	8.24e-02	1.00e+00	2ACTA2, ACTG2	5
GOBP_MYOFIBRIL_ASSEMBLY	3.40e-06	25.67	7.66	5.09e-03	2.55e-02	5MYH11, PDGFRB, TPM1, LMOD1, LDB3	59
GOBP_MUSCLE_CONTRACTION	6.74e-09	11.61	5.47	5.05e-05	5.05e-05	12ACTA2, MYL9, MYH11, MYLK, CALD1, TPM2, TPM1, LMOD1, ACTG2, PLN, EDNRB, ITGA1	352
GOBP_COLLAGEN_ACTIVATED_TYROSINE_KINASE_RECEPTOR_SIGNALING_PATHWAY	9.99e-04	51.89	5.39	3.40e-01	1.00e+00	2COL4A1, COL4A2	12
GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS	4.46e-05	14.61	4.43	3.71e-02	3.34e-01	5MYH11, PDGFRB, TPM1, LMOD1, LDB3	100
GOBP_STRIATED_MUSCLE_CELL_DEVELOPMENT	5.14e-05	14.17	4.30	3.84e-02	3.84e-01	5MYH11, PDGFRB, TPM1, LMOD1, LDB3	103
GOBP_COLLAGEN_ACTIVATED_SIGNALING_PATHWAY	1.58e-03	39.95	4.27	4.91e-01	1.00e+00	2COL4A1, COL4A2	15
GOBP_MUSCLE_SYSTEM_PROCESS	1.01e-07	8.95	4.23	2.51e-04	7.54e-04	12ACTA2, MYL9, MYH11, MYLK, CALD1, TPM2, TPM1, LMOD1, ACTG2, PLN, EDNRB, ITGA1	453
GOBP_GLOMERULAR_MESANGIUM_DEVELOPMENT	1.80e-03	37.11	3.99	5.38e-01	1.00e+00	2ACTA2, PDGFRB	16
GOBP_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE	2.28e-03	32.49	3.53	6.31e-01	1.00e+00	2COL4A1, PDGFRB	18
GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT	4.48e-08	6.27	3.30	1.67e-04	3.35e-04	18ACTA2, MYH11, MYLK, CALD1, MCAM, EPAS1, COL18A1, ENPEP, ADAMTS1, COL4A1, COL4A2, PDGFRB, TPM1, PLN, CPE, MFGE8, CSPG4, LDB3	1140
GOBP_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY	3.10e-03	27.37	3.01	8.00e-01	1.00e+00	2PDGFRB, ITGA1	21
GOBP_SMOOTH_MUSCLE_CONTRACTION	6.41e-04	11.32	2.90	2.40e-01	1.00e+00	4ACTA2, MYH11, MYLK, EDNRB	100
GOBP_BLOOD_VESSEL_MORPHOGENESIS	5.92e-06	5.94	2.81	6.33e-03	4.43e-02	12MYLK, CALD1, MCAM, EPAS1, COL18A1, ENPEP, ADAMTS1, COL4A1, COL4A2, PDGFRB, MFGE8, CSPG4	677
GOBP_VASCULATURE_DEVELOPMENT	4.35e-06	5.69	2.76	5.43e-03	3.26e-02	13ACTA2, MYLK, CALD1, MCAM, EPAS1, COL18A1, ENPEP, ADAMTS1, COL4A1, COL4A2, PDGFRB, MFGE8, CSPG4	786
GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS	1.60e-06	5.23	2.69	2.99e-03	1.20e-02	16MYH11, CALD1, MCAM, EPAS1, COL18A1, ENPEP, ADAMTS1, COL4A1, CD36, COL4A2, PDGFRB, TPM1, LMOD1, MFGE8, CSPG4, LDB3	1142
GOBP_VASCULAR_ASSOCIATED_SMOOTH_MUSCLE_CONTRACTION	4.05e-03	23.65	2.62	8.90e-01	1.00e+00	2ACTA2, EDNRB	24
GOBP_GLOMERULUS_DEVELOPMENT	1.88e-03	13.52	2.62	5.41e-01	1.00e+00	3ACTA2, ENPEP, PDGFRB	62
GOBP_MUSCLE_CELL_DEVELOPMENT	4.97e-04	8.52	2.61	2.06e-01	1.00e+00	5MYH11, PDGFRB, TPM1, LMOD1, LDB3	168
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION	1.24e-04	6.14	2.47	7.16e-02	9.31e-01	8ADAMTS4, MYH11, COL18A1, ADAMTS1, COL4A1, COL4A2, CRISPLD2, ITGA1	396

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Immunological Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GSE2405_HEAT_KILLED_LYSATE_VS_LIVE_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_24H_UP	9.73e-07	12.40	4.96	4.74e-03	4.74e-03	8RGS5, MYH11, TPM2, TAGLN, COL4A2, PARM1, ACTG2, MFGE8	200
GSE24574_BCL6_HIGH_TFH_VS_TCONV_CD4_TCELL_DN	1.17e-04	8.88	3.05	1.51e-01	5.71e-01	6CALD1, ENPEP, GUCY1A2, PDK4, PARM1, CPE	198
GSE5589_WT_VS_IL6_KO_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_DN	1.20e-04	8.83	3.04	1.51e-01	5.86e-01	6COL4A1, CD36, COL4A2, AOC3, CPE, CSPG4	199
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP	1.24e-04	8.78	3.02	1.51e-01	6.03e-01	6MYH11, COL4A1, ACTG2, MFGE8, DSTN, IGFBP7	200
GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP	1.03e-03	7.19	2.20	6.57e-01	1.00e+00	5MYL9, MYLK, TPM1, LPP, IGFBP7	198
GSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD4_TCELL_DN	1.78e-03	8.49	2.19	9.65e-01	1.00e+00	4EPAS1, GUCY1A2, PDGFRB, CSPG4	132
GSE22886_DC_VS_MONOCYTE_UP	1.08e-03	7.12	2.18	6.57e-01	1.00e+00	5MYL9, EPAS1, LPP, FILIP1L, TNS1	200
GSE19888_CTRL_VS_TCELL_MEMBRANES_ACT_MAST_CELL_PRETREAT_A3R_INH_UP	1.08e-03	7.12	2.18	6.57e-01	1.00e+00	5RGS5, ENPEP, ABCC9, EDNRB, RCAN2	200
GSE33162_HDAC3_KO_VS_HDAC3_KO_4H_LPS_STIM_MACROPHAGE_DN	1.08e-03	7.12	2.18	6.57e-01	1.00e+00	5MYLK, EPAS1, EFHD1, LMOD1, STEAP4	200
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN	4.96e-03	6.32	1.63	1.00e+00	1.00e+00	4TAGLN, ADAMTS1, PDK4, TNS1	176
GSE21360_TERTIARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN	5.06e-03	6.28	1.62	1.00e+00	1.00e+00	4CD36, LPP, IGFBP7, SLC7A2	177
GSE9509_10MIN_VS_30MIN_LPS_STIM_IL10_KO_MACROPHAGE_DN	6.95e-03	5.72	1.48	1.00e+00	1.00e+00	4ADAMTS4, MYLK, RNF152, AOC3	194
GSE25088_WT_VS_STAT6_KO_MACROPHAGE_ROSIGLITAZONE_AND_IL4_STIM_DN	7.20e-03	5.66	1.47	1.00e+00	1.00e+00	4ACTA2, MYL9, IGFBP7, RCAN2	196
GSE11057_PBMC_VS_MEM_CD4_TCELL_UP	7.32e-03	5.63	1.46	1.00e+00	1.00e+00	4MYL9, STEAP4, IGFBP7, CRISPLD2	197
GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_DN	7.32e-03	5.63	1.46	1.00e+00	1.00e+00	4RGS5, MYL9, LPP, RCAN2	197
GSE360_DC_VS_MAC_T_GONDII_UP	7.45e-03	5.60	1.45	1.00e+00	1.00e+00	4TPM1, PARM1, ACTG2, LDB3	198
GSE4142_PLASMA_CELL_VS_MEMORY_BCELL_UP	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4RGS5, MYH11, PDK4, SLC7A2	199
GSE22229_UNTREATED_VS_IMMUNOSUPP_THERAPY_RENAL_TRANSPLANT_PATIENT_PBMC_DN	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4COL4A1, COL4A2, PARM1, TNS1	199
GSE21379_WT_VS_SAP_KO_CD4_TCELL_DN	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4ENPEP, EFHD1, STEAP4, RCAN2	199
GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4MYL9, PDGFRB, ABCC9, EDNRB	199

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol	TF Rank	DNA Binding Domain	Motif Status	IUPAC PWM	GTEx	DepMap	Decartes
NOTCH3	1	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Fragment of NOTCH. Is a coactivator.
EPAS1	12	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None
CD36	18	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
LPP	28	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	znfLIM is probably not a DNA binding domain (PMID: 8506279). The protein has been reported to be coactivator for ETV4 (PMID: 16738319).
AGT	57	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
HIPK2	69	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor that can act as a coactivator or corepressor. Phosphorylates many transcription factors. (UniProt Q9H2X6)
KLF9	77	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	None	None
MYOCD	81	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Transcriptional cofactor (PMID: 12640126)
TBX2	87	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
ID4	93	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
CDKN1A	94	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
HEYL	99	Yes	Inferred motif	Monomer or homomultimer	High-throughput in vitro	None	None
SNAI2	105	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
NFIL3	128	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
ARID5B	130	Yes	Known motif	Monomer or homomultimer	100 perc ID - in vitro	Has a putative AT-hook	None
CCDC3	155	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	bZIP domain is truncated and lacks the DNA-contacting residues.
TSC22D1	156	Yes	Likely to be sequence specific TF	Monomer or homomultimer	No motif	None	TSC22D1 appears to homo- and heterodimerize with other TFs to affect transcription (PMID: 10488076). In vitro, it has been shown to bind GC-rich DNA sequences (PMID: 9022669)
TGFB1I1	163	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Available evidence suggests that it acts as a co-factor
MEF2C	169	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
NFATC4	177	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None

QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID	Singler label	Singler Delta	Activity Score	Top Singler Raw Scores
KK059-L12	Tissue_stem_cells:BM_MSC:TGFb3	0.16	897.14	Raw ScoresiPS_cells:CRL2097_foreskin: 0.46, Fibroblasts:breast: 0.45, iPS_cells:adipose_stem_cells: 0.45, Tissue_stem_cells:iliac_MSC: 0.44, Osteoblasts: 0.44, Tissue_stem_cells:BM_MSC:TGFb3: 0.44, MSC: 0.44, Fibroblasts:foreskin: 0.43, Smooth_muscle_cells:bronchial: 0.43, Chondrocytes:MSC-derived: 0.43
WK014-K9	Tissue_stem_cells:BM_MSC:TGFb3	0.18	730.50	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.46, Osteoblasts:BMP2: 0.46, Smooth_muscle_cells:vascular:IL-17: 0.46, Osteoblasts: 0.45, Fibroblasts:breast: 0.45, iPS_cells:adipose_stem_cells: 0.45, iPS_cells:CRL2097_foreskin: 0.45, Smooth_muscle_cells:vascular: 0.45, Chondrocytes:MSC-derived: 0.45
WK097-O14	Tissue_stem_cells:BM_MSC:BMP2	0.17	725.66	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.5, Fibroblasts:breast: 0.49, iPS_cells:adipose_stem_cells: 0.49, Tissue_stem_cells:BM_MSC:TGFb3: 0.49, iPS_cells:CRL2097_foreskin: 0.49, Osteoblasts: 0.49, Osteoblasts:BMP2: 0.49, Tissue_stem_cells:iliac_MSC: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.48, Smooth_muscle_cells:vascular: 0.48
WK074-I19	Endothelial_cells:lymphatic	0.19	663.06	Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.52, Endothelial_cells:lymphatic: 0.52, Endothelial_cells:blood_vessel: 0.48, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.48, Endothelial_cells:lymphatic:KSHV: 0.47, Tissue_stem_cells:BM_MSC:BMP2: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.47, Tissue_stem_cells:BM_MSC:TGFb3: 0.47, Endothelial_cells:HUVEC:VEGF: 0.47
WK014-I21	Tissue_stem_cells:BM_MSC:TGFb3	0.17	628.43	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.48, Tissue_stem_cells:BM_MSC:BMP2: 0.47, iPS_cells:adipose_stem_cells: 0.47, Fibroblasts:breast: 0.47, Smooth_muscle_cells:vascular:IL-17: 0.47, Osteoblasts: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Tissue_stem_cells:iliac_MSC: 0.47, Osteoblasts:BMP2: 0.46, Smooth_muscle_cells:vascular: 0.46
WK073-O2	Smooth_muscle_cells:vascular:IL-17	0.14	620.24	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.42, Tissue_stem_cells:BM_MSC:BMP2: 0.41, Fibroblasts:breast: 0.41, Smooth_muscle_cells:vascular:IL-17: 0.41, Smooth_muscle_cells:vascular: 0.4, iPS_cells:CRL2097_foreskin: 0.4, iPS_cells:adipose_stem_cells: 0.4, Osteoblasts: 0.4, Chondrocytes:MSC-derived: 0.4, Osteoblasts:BMP2: 0.4
KK052-K12	Endothelial_cells:HUVEC:Borrelia_burgdorferi	0.14	595.17	Raw ScoresFibroblasts:breast: 0.47, Endothelial_cells:lymphatic:TNFa_48h: 0.47, Endothelial_cells:lymphatic: 0.46, iPS_cells:CRL2097_foreskin: 0.46, iPS_cells:adipose_stem_cells: 0.46, Tissue_stem_cells:BM_MSC:TGFb3: 0.46, Smooth_muscle_cells:vascular: 0.46, Osteoblasts: 0.45, Endothelial_cells:HUVEC:VEGF: 0.45, Tissue_stem_cells:iliac_MSC: 0.45
WK012-K20	Tissue_stem_cells:BM_MSC:BMP2	0.21	587.56	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.49, Fibroblasts:breast: 0.49, iPS_cells:adipose_stem_cells: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.49, Osteoblasts: 0.48, Chondrocytes:MSC-derived: 0.48, Tissue_stem_cells:iliac_MSC: 0.48, iPS_cells:CRL2097_foreskin: 0.48, Smooth_muscle_cells:bronchial: 0.47, Smooth_muscle_cells:vascular: 0.47
WK032-M9	Tissue_stem_cells:BM_MSC:BMP2	0.16	535.66	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.46, Tissue_stem_cells:BM_MSC:BMP2: 0.45, iPS_cells:CRL2097_foreskin: 0.45, iPS_cells:adipose_stem_cells: 0.44, Osteoblasts:BMP2: 0.44, Osteoblasts: 0.44, Fibroblasts:breast: 0.44, Smooth_muscle_cells:vascular:IL-17: 0.44, Tissue_stem_cells:iliac_MSC: 0.44, Smooth_muscle_cells:vascular: 0.44
TM38-M16	Smooth_muscle_cells:vascular:IL-17	0.14	483.99	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.4, Smooth_muscle_cells:vascular:IL-17: 0.4, iPS_cells:CRL2097_foreskin: 0.4, Fibroblasts:breast: 0.39, iPS_cells:adipose_stem_cells: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39, Chondrocytes:MSC-derived: 0.39, Osteoblasts: 0.39, Smooth_muscle_cells:vascular: 0.39, Tissue_stem_cells:iliac_MSC: 0.39
KK059-H19	MSC	0.18	469.31	Raw ScoresMSC: 0.48, Fibroblasts:breast: 0.47, iPS_cells:adipose_stem_cells: 0.47, iPS_cells:CRL2097_foreskin: 0.47, Neurons:Schwann_cell: 0.47, Fibroblasts:foreskin: 0.46, iPS_cells:skin_fibroblast: 0.46, Smooth_muscle_cells:vascular: 0.46, iPS_cells:foreskin_fibrobasts: 0.46, Tissue_stem_cells:lipoma-derived_MSC: 0.46
WK100-F4	Tissue_stem_cells:BM_MSC:TGFb3	0.16	464.34	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.44, Tissue_stem_cells:BM_MSC:BMP2: 0.43, Chondrocytes:MSC-derived: 0.42, Osteoblasts:BMP2: 0.42, Osteoblasts: 0.42, iPS_cells:CRL2097_foreskin: 0.42, Smooth_muscle_cells:vascular:IL-17: 0.41, iPS_cells:adipose_stem_cells: 0.41, Tissue_stem_cells:BM_MSC: 0.41, Tissue_stem_cells:iliac_MSC: 0.41
WK014-K13	Tissue_stem_cells:BM_MSC:TGFb3	0.15	456.76	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.37, Smooth_muscle_cells:vascular:IL-17: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, iPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC: 0.36, Fibroblasts:breast: 0.36, Smooth_muscle_cells:vascular: 0.35, Chondrocytes:MSC-derived: 0.35, iPS_cells:CRL2097_foreskin: 0.35, Osteoblasts:BMP2: 0.35
KK059-D17	Tissue_stem_cells:BM_MSC:TGFb3	0.15	449.23	Raw ScoresiPS_cells:CRL2097_foreskin: 0.41, Fibroblasts:breast: 0.41, iPS_cells:adipose_stem_cells: 0.41, Smooth_muscle_cells:bronchial: 0.41, Tissue_stem_cells:BM_MSC:TGFb3: 0.41, Osteoblasts: 0.41, Chondrocytes:MSC-derived: 0.41, Tissue_stem_cells:iliac_MSC: 0.4, Smooth_muscle_cells:bronchial:vit_D: 0.4, MSC: 0.4
WK065-B6	Tissue_stem_cells:BM_MSC:TGFb3	0.17	442.41	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.43, Fibroblasts:breast: 0.43, iPS_cells:adipose_stem_cells: 0.43, iPS_cells:CRL2097_foreskin: 0.43, Chondrocytes:MSC-derived: 0.43, Tissue_stem_cells:BM_MSC:BMP2: 0.43, Osteoblasts: 0.42, Tissue_stem_cells:iliac_MSC: 0.42, Osteoblasts:BMP2: 0.42, Smooth_muscle_cells:bronchial: 0.42
WK097-C5	Tissue_stem_cells:BM_MSC:BMP2	0.17	429.02	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.45, Fibroblasts:breast: 0.45, Tissue_stem_cells:BM_MSC:BMP2: 0.45, iPS_cells:adipose_stem_cells: 0.45, iPS_cells:CRL2097_foreskin: 0.45, Osteoblasts: 0.45, Osteoblasts:BMP2: 0.44, Smooth_muscle_cells:vascular:IL-17: 0.44, Smooth_muscle_cells:vascular: 0.44, Tissue_stem_cells:BM_MSC: 0.44
WK074-B21	Tissue_stem_cells:BM_MSC:BMP2	0.16	424.24	Raw ScoresiPS_cells:adipose_stem_cells: 0.43, Tissue_stem_cells:BM_MSC:TGFb3: 0.43, Tissue_stem_cells:BM_MSC:BMP2: 0.43, Fibroblasts:breast: 0.43, Osteoblasts: 0.42, Smooth_muscle_cells:bronchial: 0.42, Smooth_muscle_cells:vascular:IL-17: 0.42, iPS_cells:CRL2097_foreskin: 0.42, Smooth_muscle_cells:vascular: 0.42, Osteoblasts:BMP2: 0.41
WK012-H17	Tissue_stem_cells:BM_MSC:BMP2	0.16	407.96	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.43, Tissue_stem_cells:BM_MSC:BMP2: 0.42, Smooth_muscle_cells:vascular:IL-17: 0.42, Smooth_muscle_cells:vascular: 0.41, Osteoblasts: 0.41, iPS_cells:adipose_stem_cells: 0.41, Tissue_stem_cells:BM_MSC: 0.41, Fibroblasts:breast: 0.41, Osteoblasts:BMP2: 0.41, Chondrocytes:MSC-derived: 0.41
KK002-I4	Tissue_stem_cells:BM_MSC:TGFb3	0.14	406.20	Raw ScoresiPS_cells:CRL2097_foreskin: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, Fibroblasts:breast: 0.37, iPS_cells:adipose_stem_cells: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.37, Smooth_muscle_cells:bronchial: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, Osteoblasts: 0.37, Smooth_muscle_cells:bronchial:vit_D: 0.36, Fibroblasts:foreskin: 0.36
WK032-G18	Tissue_stem_cells:BM_MSC:BMP2	0.17	395.25	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.43, iPS_cells:adipose_stem_cells: 0.42, Fibroblasts:breast: 0.42, Smooth_muscle_cells:vascular:IL-17: 0.42, Tissue_stem_cells:BM_MSC:BMP2: 0.42, Osteoblasts:BMP2: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Osteoblasts: 0.41, Smooth_muscle_cells:vascular: 0.41, Tissue_stem_cells:BM_MSC: 0.4
WK012-F3	Endothelial_cells:blood_vessel	0.20	391.86	Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.57, Endothelial_cells:lymphatic: 0.56, Endothelial_cells:blood_vessel: 0.55, Endothelial_cells:lymphatic:KSHV: 0.55, Endothelial_cells:HUVEC: 0.54, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.54, Endothelial_cells:HUVEC:VEGF: 0.53, Endothelial_cells:HUVEC:IL-1b: 0.53, Endothelial_cells:HUVEC:B._anthracis_LT: 0.53, Endothelial_cells:HUVEC:PR8-infected: 0.53
KK001-F1	Tissue_stem_cells:BM_MSC:TGFb3	0.16	383.33	Raw ScoresFibroblasts:breast: 0.39, iPS_cells:adipose_stem_cells: 0.39, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Osteoblasts: 0.38, iPS_cells:CRL2097_foreskin: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Tissue_stem_cells:iliac_MSC: 0.38, Chondrocytes:MSC-derived: 0.37, Smooth_muscle_cells:vascular: 0.37, MSC: 0.37
WK012-E3	Tissue_stem_cells:BM_MSC:BMP2	0.21	377.89	Raw ScoresFibroblasts:breast: 0.51, iPS_cells:CRL2097_foreskin: 0.5, iPS_cells:adipose_stem_cells: 0.5, Osteoblasts: 0.5, Tissue_stem_cells:BM_MSC:TGFb3: 0.5, Osteoblasts:BMP2: 0.5, Tissue_stem_cells:BM_MSC:BMP2: 0.5, Smooth_muscle_cells:vascular: 0.49, Tissue_stem_cells:BM_MSC: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49
WK036-P8	Tissue_stem_cells:BM_MSC:BMP2	0.21	374.69	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.51, iPS_cells:adipose_stem_cells: 0.51, Tissue_stem_cells:BM_MSC:BMP2: 0.51, Fibroblasts:breast: 0.51, Osteoblasts: 0.5, Smooth_muscle_cells:vascular:IL-17: 0.5, Osteoblasts:BMP2: 0.5, Smooth_muscle_cells:vascular: 0.5, iPS_cells:CRL2097_foreskin: 0.49, Tissue_stem_cells:BM_MSC: 0.49
WK014-L6	Tissue_stem_cells:BM_MSC:TGFb3	0.17	364.14	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.43, iPS_cells:adipose_stem_cells: 0.42, Smooth_muscle_cells:vascular:IL-17: 0.42, Tissue_stem_cells:BM_MSC:BMP2: 0.42, Fibroblasts:breast: 0.42, Smooth_muscle_cells:vascular: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Osteoblasts: 0.41, Osteoblasts:BMP2: 0.41, Tissue_stem_cells:BM_MSC: 0.41
WK036-J2	Endothelial_cells:blood_vessel	0.18	339.71	Raw ScoresEndothelial_cells:lymphatic: 0.49, Endothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:blood_vessel: 0.49, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:lymphatic:KSHV: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.48, Endothelial_cells:HUVEC:IFNg: 0.47, Endothelial_cells:HUVEC:PR8-infected: 0.47, Endothelial_cells:HUVEC:VEGF: 0.47, Endothelial_cells:HUVEC:IL-1b: 0.47
WK012-N19	Endothelial_cells:blood_vessel	0.19	335.41	Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.49, Endothelial_cells:lymphatic: 0.49, Endothelial_cells:lymphatic:KSHV: 0.49, Endothelial_cells:blood_vessel: 0.48, Endothelial_cells:HUVEC: 0.48, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.48, Endothelial_cells:HUVEC:IL-1b: 0.47, Endothelial_cells:HUVEC:VEGF: 0.46, Endothelial_cells:HUVEC:B._anthracis_LT: 0.46, Endothelial_cells:HUVEC:PR8-infected: 0.45
WK012-F16	Tissue_stem_cells:BM_MSC:BMP2	0.18	333.15	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.46, Tissue_stem_cells:BM_MSC:BMP2: 0.45, iPS_cells:adipose_stem_cells: 0.45, Smooth_muscle_cells:vascular:IL-17: 0.44, Fibroblasts:breast: 0.44, Osteoblasts: 0.44, iPS_cells:CRL2097_foreskin: 0.44, Smooth_muscle_cells:vascular: 0.44, Tissue_stem_cells:iliac_MSC: 0.44, Osteoblasts:BMP2: 0.44
WK014-O15	Tissue_stem_cells:BM_MSC:BMP2	0.13	315.90	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.39, Smooth_muscle_cells:vascular:IL-17: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Fibroblasts:breast: 0.38, iPS_cells:adipose_stem_cells: 0.37, iPS_cells:CRL2097_foreskin: 0.37, Smooth_muscle_cells:vascular: 0.37, Tissue_stem_cells:iliac_MSC: 0.37, Osteoblasts:BMP2: 0.37, Osteoblasts: 0.37
WK016-I11	Tissue_stem_cells:BM_MSC:BMP2	0.14	314.67	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.36, Osteoblasts: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Tissue_stem_cells:iliac_MSC: 0.35, Smooth_muscle_cells:bronchial: 0.35, Fibroblasts:breast: 0.35, iPS_cells:CRL2097_foreskin: 0.35, iPS_cells:adipose_stem_cells: 0.35, Osteoblasts:BMP2: 0.35, Smooth_muscle_cells:bronchial:vit_D: 0.35
WK012-N8	Chondrocytes:MSC-derived	0.14	313.06	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.36, Chondrocytes:MSC-derived: 0.36, Osteoblasts: 0.36, Smooth_muscle_cells:vascular:IL-17: 0.36, iPS_cells:CRL2097_foreskin: 0.36, iPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Osteoblasts:BMP2: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Smooth_muscle_cells:vascular: 0.35
WK014-P4	Endothelial_cells:blood_vessel	0.19	307.61	Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.51, Endothelial_cells:lymphatic: 0.51, Endothelial_cells:blood_vessel: 0.5, Endothelial_cells:lymphatic:KSHV: 0.49, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.49, Endothelial_cells:HUVEC: 0.49, Endothelial_cells:HUVEC:IL-1b: 0.49, Endothelial_cells:HUVEC:VEGF: 0.48, Endothelial_cells:HUVEC:B._anthracis_LT: 0.47, Endothelial_cells:HUVEC:PR8-infected: 0.47
WK020-L9	Tissue_stem_cells:BM_MSC:BMP2	0.14	303.57	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.37, iPS_cells:CRL2097_foreskin: 0.36, iPS_cells:adipose_stem_cells: 0.36, Fibroblasts:breast: 0.36, Osteoblasts:BMP2: 0.36, Osteoblasts: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.36, Tissue_stem_cells:iliac_MSC: 0.35, Smooth_muscle_cells:bronchial: 0.35, Tissue_stem_cells:BM_MSC: 0.35
KK052-H23	Tissue_stem_cells:BM_MSC:TGFb3	0.17	298.01	Raw ScoresFibroblasts:breast: 0.39, Tissue_stem_cells:BM_MSC:TGFb3: 0.39, iPS_cells:adipose_stem_cells: 0.39, Tissue_stem_cells:iliac_MSC: 0.39, iPS_cells:CRL2097_foreskin: 0.38, Osteoblasts: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Smooth_muscle_cells:bronchial: 0.38, Osteoblasts:BMP2: 0.38, Smooth_muscle_cells:vascular: 0.38
KK001-I20	Fibroblasts:breast	0.16	279.83	Raw ScoresMSC: 0.46, iPS_cells:adipose_stem_cells: 0.46, Fibroblasts:breast: 0.45, iPS_cells:CRL2097_foreskin: 0.45, Smooth_muscle_cells:vascular: 0.45, Tissue_stem_cells:BM_MSC: 0.45, Fibroblasts:foreskin: 0.45, Tissue_stem_cells:BM_MSC:BMP2: 0.44, Neurons:Schwann_cell: 0.44, Tissue_stem_cells:BM_MSC:TGFb3: 0.44
WK014-D3	Endothelial_cells:blood_vessel	0.17	269.98	Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:HUVEC: 0.41, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4, Tissue_stem_cells:BM_MSC:TGFb3: 0.4, Endothelial_cells:HUVEC:IL-1b: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39
WK014-I8	Tissue_stem_cells:iliac_MSC	0.16	262.08	Raw ScoresiPS_cells:adipose_stem_cells: 0.4, Fibroblasts:breast: 0.39, Tissue_stem_cells:iliac_MSC: 0.39, Osteoblasts: 0.39, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, Smooth_muscle_cells:vascular: 0.38, MSC: 0.38, iPS_cells:CRL2097_foreskin: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Tissue_stem_cells:BM_MSC: 0.38
WK073-L17	Tissue_stem_cells:BM_MSC:TGFb3	0.14	254.00	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, iPS_cells:adipose_stem_cells: 0.33, Smooth_muscle_cells:vascular:IL-17: 0.33, Smooth_muscle_cells:vascular: 0.33, Osteoblasts: 0.33, Tissue_stem_cells:iliac_MSC: 0.33, Fibroblasts:breast: 0.33, Osteoblasts:BMP2: 0.33, iPS_cells:CRL2097_foreskin: 0.33
WK079-L15	Tissue_stem_cells:BM_MSC:TGFb3	0.15	251.60	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.39, Tissue_stem_cells:BM_MSC:TGFb3: 0.39, iPS_cells:adipose_stem_cells: 0.38, Smooth_muscle_cells:bronchial: 0.38, Fibroblasts:breast: 0.38, Smooth_muscle_cells:vascular:IL-17: 0.37, Smooth_muscle_cells:bronchial:vit_D: 0.37, Osteoblasts: 0.37, Smooth_muscle_cells:vascular: 0.37, Chondrocytes:MSC-derived: 0.37
KK001-D10	Tissue_stem_cells:BM_MSC:TGFb3	0.14	248.12	Raw ScoresTissue_stem_cells:iliac_MSC: 0.38, Fibroblasts:breast: 0.38, iPS_cells:CRL2097_foreskin: 0.38, Tissue_stem_cells:BM_MSC:TGFb3: 0.38, iPS_cells:adipose_stem_cells: 0.38, Tissue_stem_cells:BM_MSC:BMP2: 0.38, Smooth_muscle_cells:bronchial: 0.38, Osteoblasts: 0.37, Smooth_muscle_cells:bronchial:vit_D: 0.37, Smooth_muscle_cells:vascular: 0.37
WK049-L13	iPS_cells:adipose_stem_cells	0.17	246.44	Raw ScoresiPS_cells:adipose_stem_cells: 0.39, Fibroblasts:breast: 0.39, iPS_cells:CRL2097_foreskin: 0.38, Osteoblasts:BMP2: 0.37, Osteoblasts: 0.37, Tissue_stem_cells:BM_MSC:TGFb3: 0.37, Smooth_muscle_cells:vascular: 0.37, Chondrocytes:MSC-derived: 0.37, Smooth_muscle_cells:vascular:IL-17: 0.36, Smooth_muscle_cells:bronchial: 0.36
WK080-H16	Tissue_stem_cells:BM_MSC:TGFb3	0.10	245.61	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.27, Smooth_muscle_cells:vascular:IL-17: 0.26, Fibroblasts:breast: 0.26, Tissue_stem_cells:iliac_MSC: 0.26, Osteoblasts: 0.26, iPS_cells:adipose_stem_cells: 0.26, Chondrocytes:MSC-derived: 0.26, Smooth_muscle_cells:vascular: 0.26, Neurons:Schwann_cell: 0.26
WK012-M12	Tissue_stem_cells:BM_MSC:TGFb3	0.15	240.13	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.36, Fibroblasts:breast: 0.36, Tissue_stem_cells:iliac_MSC: 0.35, iPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, iPS_cells:CRL2097_foreskin: 0.35, Smooth_muscle_cells:vascular:IL-17: 0.34, Osteoblasts: 0.34, Chondrocytes:MSC-derived: 0.34, Osteoblasts:BMP2: 0.34
WK079-J19	Tissue_stem_cells:BM_MSC:BMP2	0.18	236.55	Raw ScoresTissue_stem_cells:BM_MSC:BMP2: 0.41, iPS_cells:adipose_stem_cells: 0.41, Tissue_stem_cells:BM_MSC:TGFb3: 0.41, Smooth_muscle_cells:vascular:IL-17: 0.41, Smooth_muscle_cells:vascular: 0.41, Osteoblasts: 0.41, Fibroblasts:breast: 0.41, iPS_cells:CRL2097_foreskin: 0.41, Chondrocytes:MSC-derived: 0.41, Tissue_stem_cells:BM_MSC: 0.4
WK036-J20	Tissue_stem_cells:BM_MSC:TGFb3	0.16	233.75	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.41, Fibroblasts:breast: 0.41, Smooth_muscle_cells:vascular: 0.4, Smooth_muscle_cells:vascular:IL-17: 0.4, Chondrocytes:MSC-derived: 0.4, iPS_cells:adipose_stem_cells: 0.4, Tissue_stem_cells:BM_MSC:BMP2: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Osteoblasts: 0.4, Osteoblasts:BMP2: 0.39
WK014-D20	Smooth_muscle_cells:vascular:IL-17	0.14	233.26	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.36, Smooth_muscle_cells:vascular:IL-17: 0.36, iPS_cells:CRL2097_foreskin: 0.35, iPS_cells:adipose_stem_cells: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Fibroblasts:breast: 0.35, Chondrocytes:MSC-derived: 0.35, Tissue_stem_cells:BM_MSC: 0.35, Smooth_muscle_cells:vascular: 0.35, Osteoblasts: 0.35
WK073-B1	Endothelial_cells:blood_vessel	0.15	231.42	Raw ScoresEndothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:HUVEC: 0.4, Tissue_stem_cells:BM_MSC:TGFb3: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC:VEGF: 0.39, Tissue_stem_cells:BM_MSC:BMP2: 0.39, Endothelial_cells:HUVEC:IL-1b: 0.39
WK017-C6	Endothelial_cells:lymphatic:TNFa_48h	0.11	229.97	Raw ScoresiPS_cells:adipose_stem_cells: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Smooth_muscle_cells:bronchial: 0.36, Fibroblasts:breast: 0.36, Osteoblasts: 0.36, Tissue_stem_cells:iliac_MSC: 0.36, iPS_cells:CRL2097_foreskin: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.35, Smooth_muscle_cells:bronchial:vit_D: 0.35, Smooth_muscle_cells:vascular: 0.35
WK012-L6	Tissue_stem_cells:BM_MSC:BMP2	0.19	228.85	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.49, Smooth_muscle_cells:vascular:IL-17: 0.49, Fibroblasts:breast: 0.49, Tissue_stem_cells:BM_MSC:BMP2: 0.49, iPS_cells:adipose_stem_cells: 0.49, Smooth_muscle_cells:vascular: 0.48, Osteoblasts: 0.48, Osteoblasts:BMP2: 0.48, Chondrocytes:MSC-derived: 0.48, iPS_cells:CRL2097_foreskin: 0.48
TM37-H18	Tissue_stem_cells:BM_MSC:TGFb3	0.15	226.28	Raw ScoresTissue_stem_cells:BM_MSC:TGFb3: 0.42, Tissue_stem_cells:BM_MSC:BMP2: 0.41, iPS_cells:adipose_stem_cells: 0.41, Smooth_muscle_cells:vascular:IL-17: 0.41, Osteoblasts: 0.41, Smooth_muscle_cells:vascular: 0.41, Fibroblasts:breast: 0.4, Tissue_stem_cells:BM_MSC: 0.4, Tissue_stem_cells:iliac_MSC: 0.4, iPS_cells:CRL2097_foreskin: 0.4

Below shows the significant enrichments of this GEP for literature curated gene lists
This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.72e-04
Mean rank of genes in gene set: 4488.96
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS5	0.0102950	2	GTEx	DepMap	Descartes	44.82	1941.28
ACTA2	0.0102396	3	GTEx	DepMap	Descartes	25.28	4742.88
MYL9	0.0098854	5	GTEx	DepMap	Descartes	11.53	1057.80
MYH11	0.0098162	6	GTEx	DepMap	Descartes	5.78	253.83
MYLK	0.0098068	7	GTEx	DepMap	Descartes	6.17	154.64
TPM2	0.0081341	9	GTEx	DepMap	Descartes	6.11	1005.19
TAGLN	0.0076236	11	GTEx	DepMap	Descartes	21.69	1517.90
COL4A1	0.0070518	16	GTEx	DepMap	Descartes	16.86	540.87
TPM1	0.0065753	24	GTEx	DepMap	Descartes	7.28	442.76
ACTG2	0.0061135	30	GTEx	DepMap	Descartes	2.13	286.53
IGFBP7	0.0054871	41	GTEx	DepMap	Descartes	90.37	14869.03
ITGA7	0.0050300	51	GTEx	DepMap	Descartes	1.59	118.27
BGN	0.0040914	86	GTEx	DepMap	Descartes	25.62	2315.20
THY1	0.0040206	91	GTEx	DepMap	Descartes	4.98	220.84
TNC	0.0035879	114	GTEx	DepMap	Descartes	4.52	126.72
MEF2C	0.0027738	169	GTEx	DepMap	Descartes	1.31	41.45
PGF	0.0026531	179	GTEx	DepMap	Descartes	0.78	60.12
COL12A1	0.0014977	417	GTEx	DepMap	Descartes	3.95	74.59
TGFB2	0.0012224	511	GTEx	DepMap	Descartes	0.65	29.32
FN1	0.0010430	603	GTEx	DepMap	Descartes	20.12	458.37
MMP11	0.0009027	706	GTEx	DepMap	Descartes	0.67	36.50
THBS1	0.0008802	726	GTEx	DepMap	Descartes	13.75	493.10
COL14A1	0.0008376	761	GTEx	DepMap	Descartes	7.66	224.03
VEGFA	0.0006290	1000	GTEx	DepMap	Descartes	4.42	86.86
HOPX	0.0005433	1132	GTEx	DepMap	Descartes	0.52	45.65
TGFBR1	0.0004226	1357	GTEx	DepMap	Descartes	1.08	36.35
TMEM119	0.0003760	1493	GTEx	DepMap	Descartes	1.41	106.08
COL5A2	0.0003646	1532	GTEx	DepMap	Descartes	2.91	91.63
COL13A1	0.0003198	1689	GTEx	DepMap	Descartes	0.04	2.66
THBS2	0.0001220	2736	GTEx	DepMap	Descartes	6.67	233.48
CNN3	0.0000369	3562	GTEx	DepMap	Descartes	2.41	283.82
COL5A1	-0.0000186	4324	GTEx	DepMap	Descartes	4.83	118.84
POSTN	-0.0002251	8252	GTEx	DepMap	Descartes	5.59	309.13
VCAN	-0.0003269	9767	GTEx	DepMap	Descartes	7.64	130.59
COL10A1	-0.0003809	10349	GTEx	DepMap	Descartes	0.38	22.13
WNT5A	-0.0003922	10458	GTEx	DepMap	Descartes	0.05	1.33
CNN2	-0.0004806	11131	GTEx	DepMap	Descartes	1.68	147.46
IGFBP3	-0.0005971	11687	GTEx	DepMap	Descartes	1.35	121.68
TGFB1	-0.0006353	11793	GTEx	DepMap	Descartes	0.71	61.47
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
COL11A1	-0.0007002	11987	GTEx	DepMap	Descartes	0.11	2.01
COL15A1	-0.0007879	12155	GTEx	DepMap	Descartes	2.07	67.19
COL1A1	-0.0008282	12222	GTEx	DepMap	Descartes	77.29	2593.54
COL3A1	-0.0009223	12325	GTEx	DepMap	Descartes	40.12	1509.56
COL8A1	-0.0010674	12422	GTEx	DepMap	Descartes	1.97	67.70
MMP2	-0.0012325	12487	GTEx	DepMap	Descartes	2.34	126.83
TGFBR2	-0.0015196	12532	GTEx	DepMap	Descartes	1.51	52.48
LUM	-0.0019873	12547	GTEx	DepMap	Descartes	6.44	471.80
DCN	-0.0023171	12549	GTEx	DepMap	Descartes	10.13	309.47

Myofibroblasts (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ACTA2+ Myofibroblasts were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.36e-03
Mean rank of genes in gene set: 6.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ACTA2	0.0102396	3	GTEx	DepMap	Descartes	25.28	4742.88
MYH11	0.0098162	6	GTEx	DepMap	Descartes	5.78	253.83
TAGLN	0.0076236	11	GTEx	DepMap	Descartes	21.69	1517.90

EMT I melanoma (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was melanoma specific.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.80e-03
Mean rank of genes in gene set: 185
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPM1	0.0065753	24	GTEx	DepMap	Descartes	7.28	442.76
RRAS	0.0020882	263	GTEx	DepMap	Descartes	0.85	192.01
CAV1	0.0020638	268	GTEx	DepMap	Descartes	3.96	334.01

EMT II (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in HNSCC cell lines:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.82e-03
Mean rank of genes in gene set: 1586.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AXL	0.0030192	151	GTEx	DepMap	Descartes	2.21	121.35
FN1	0.0010430	603	GTEx	DepMap	Descartes	20.12	458.37
VIM	0.0004713	1268	GTEx	DepMap	Descartes	43.93	3612.93
COL5A1	-0.0000186	4324	GTEx	DepMap	Descartes	4.83	118.84

p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.16e-02
Mean rank of genes in gene set: 459.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDKN1A	0.0039679	94	GTEx	DepMap	Descartes	18.46	2030.09
NEAT1	0.0007654	825	GTEx	DepMap	Descartes	38.94	429.15

Stress response (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.86e-02
Mean rank of genes in gene set: 1919.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
JUNB	0.0013844	447	GTEx	DepMap	Descartes	18.35	2492.40
FOS	0.0002855	1821	GTEx	DepMap	Descartes	14.47	1819.96
JUN	0.0000432	3490	GTEx	DepMap	Descartes	7.74	620.49

Stromal 1 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.20e-02
Mean rank of genes in gene set: 3738.86
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL27A1	0.0016584	371	GTEx	DepMap	Descartes	1.00	31.99
TGFB2	0.0012224	511	GTEx	DepMap	Descartes	0.65	29.32
HMGA2	0.0004061	1399	GTEx	DepMap	Descartes	0.12	3.27
MMP14	0.0002794	1840	GTEx	DepMap	Descartes	1.74	96.18
NFIB	0.0002170	2125	GTEx	DepMap	Descartes	3.89	101.93
CHD3	-0.0002577	8774	GTEx	DepMap	Descartes	1.31	37.95
IGSF3	-0.0004849	11152	GTEx	DepMap	Descartes	0.04	0.61

Stress response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.65e-02
Mean rank of genes in gene set: 3371.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GADD45B	0.0025693	188	GTEx	DepMap	Descartes	6.33	910.92
ATF3	0.0015263	408	GTEx	DepMap	Descartes	6.24	789.81
SQSTM1	0.0007713	819	GTEx	DepMap	Descartes	10.88	841.51
GADD45A	-0.0000433	4692	GTEx	DepMap	Descartes	3.77	618.74
DDIT3	-0.0004264	10749	GTEx	DepMap	Descartes	0.38	84.74

Meta_9 ATRX (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-02
Mean rank of genes in gene set: 1839.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZFHX3	0.0019748	293	GTEx	DepMap	Descartes	2.86	47.26
ATRX	0.0000520	3386	GTEx	DepMap	Descartes	2.99	56.98

Mesenchymal (Kildisiute)
Mesenchymal markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.22e-02
Mean rank of genes in gene set: 23
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.006588	23	GTEx	DepMap	Descartes	6.22	279.77

Endothelium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.31e-02
Mean rank of genes in gene set: 60
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	0.0047122	60	GTEx	DepMap	Descartes	8.55	716.85

Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.45e-02
Mean rank of genes in gene set: 2718.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EIF3L	0.0006973	903	GTEx	DepMap	Descartes	3.29	218.05
EIF3E	0.0003261	1657	GTEx	DepMap	Descartes	2.66	300.69
EIF3F	-0.0000905	5596	GTEx	DepMap	Descartes	1.43	40.85

Mixed phenotype identified at the fate split point mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells. markers are of the split point where SCPs differentiate.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.89e-02
Mean rank of genes in gene set: 276
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77

Kidney Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.47e-02
Mean rank of genes in gene set: 782
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LYPD1	0.0008152	782	GTEx	DepMap	Descartes	0.25	12.35

Pigmentation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, Skin pigmentation genes, identified in melanoma.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.57e-02
Mean rank of genes in gene set: 3542.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PMEL	0.0002856	1820	GTEx	DepMap	Descartes	0.02	1.16
MITF	0.0002011	2197	GTEx	DepMap	Descartes	0.28	14.72
MLANA	0.0000001	4055	GTEx	DepMap	Descartes	0.00	0.00
DCT	-0.0001147	6097	GTEx	DepMap	Descartes	0.00	0.00

Bridge region mesencchymal (Olsen)
Marker genes shown in Fig. 3A of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - Cells were ordered by pseudotime in the bridge region, this first group of cells were from the mesenchymal part of the trajectory.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.52e-02
Mean rank of genes in gene set: 4830.92
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CALD1	0.0085909	8	GTEx	DepMap	Descartes	14.98	735.14
BGN	0.0040914	86	GTEx	DepMap	Descartes	25.62	2315.20
NPNT	0.0024997	201	GTEx	DepMap	Descartes	0.43	22.11
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
MYC	0.0019468	300	GTEx	DepMap	Descartes	3.14	248.74
MAFF	0.0012127	514	GTEx	DepMap	Descartes	5.19	396.97
FGF1	0.0009280	683	GTEx	DepMap	Descartes	0.17	12.74
TNNT2	-0.0000537	4858	GTEx	DepMap	Descartes	0.02	0.87
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62
KLF4	-0.0005313	11415	GTEx	DepMap	Descartes	3.57	276.95
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
PODXL	-0.0008018	12180	GTEx	DepMap	Descartes	0.72	17.29
LUM	-0.0019873	12547	GTEx	DepMap	Descartes	6.44	471.80

Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.75e-02
Mean rank of genes in gene set: 3699.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPI1	0.0007690	822	GTEx	DepMap	Descartes	4.01	502.47
NPM1	0.0005031	1203	GTEx	DepMap	Descartes	8.27	1032.66
MIF	0.0000439	3477	GTEx	DepMap	Descartes	0.31	71.63
TK1	-0.0002918	9297	GTEx	DepMap	Descartes	0.05	5.13

IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.80e-02
Mean rank of genes in gene set: 3977.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IFIT2	0.0009288	681	GTEx	DepMap	Descartes	0.25	16.36
IFIT3	0.0009213	688	GTEx	DepMap	Descartes	0.60	50.33
ISG15	0.0006216	1009	GTEx	DepMap	Descartes	0.98	236.13
IFIT1	-0.0000858	5499	GTEx	DepMap	Descartes	0.23	9.70
ISG20	-0.0007118	12009	GTEx	DepMap	Descartes	0.21	7.01

Melanocytes (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.25e-02
Mean rank of genes in gene set: 3371.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PMEL	0.0002856	1820	GTEx	DepMap	Descartes	0.02	1.16
MITF	0.0002011	2197	GTEx	DepMap	Descartes	0.28	14.72
DCT	-0.0001147	6097	GTEx	DepMap	Descartes	0.00	0.00

Bridge (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.33e-01
Mean rank of genes in gene set: 3951.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB4	0.0003596	1546	GTEx	DepMap	Descartes	0.03	0.94
CDH9	-0.0000495	4792	GTEx	DepMap	Descartes	0.00	0.07
CTTNBP2	-0.0000867	5516	GTEx	DepMap	Descartes	0.01	0.31

Definitive Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Definitive Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.69e-01
Mean rank of genes in gene set: 4540
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPE	0.0057214	38	GTEx	DepMap	Descartes	6.61	662.63
CHCHD10	0.0012527	497	GTEx	DepMap	Descartes	0.91	198.73
CALN1	-0.0001210	6227	GTEx	DepMap	Descartes	0.00	0.00
GREB1	-0.0005278	11398	GTEx	DepMap	Descartes	0.02	0.26

Liver Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.95e-01
Mean rank of genes in gene set: 4891.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VTN	0.0001369	2638	GTEx	DepMap	Descartes	0.02	2.72
AHSG	-0.0001654	7145	GTEx	DepMap	Descartes	0.00	0.00

Myelination (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are state as being involved in Myelination and are expressed in the Schwann cell precursor cluster of their UMAP (Fig. 1D), these are suggested to represent more mature myelinating Schwann cells. MPZ is Myelin Protien Zero.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.40e-01
Mean rank of genes in gene set: 5218.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LGI4	0.0005450	1130	GTEx	DepMap	Descartes	0.46	42.15
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56

EMT III (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in non-cycling cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.09e-01
Mean rank of genes in gene set: 5856
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LAMA3	0.0017130	350	GTEx	DepMap	Descartes	0.31	7.57
LAMB3	0.0001574	2480	GTEx	DepMap	Descartes	0.06	3.89
JUP	-0.0002984	9391	GTEx	DepMap	Descartes	0.53	23.69
ITGA2	-0.0004936	11203	GTEx	DepMap	Descartes	0.35	8.59

Stroma (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Stroma cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.32e-01
Mean rank of genes in gene set: 5999.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL6A1	0.0012291	509	GTEx	DepMap	Descartes	11.67	629.12
FN1	0.0010430	603	GTEx	DepMap	Descartes	20.12	458.37
COL5A1	-0.0000186	4324	GTEx	DepMap	Descartes	4.83	118.84
GPC3	-0.0008402	12236	GTEx	DepMap	Descartes	0.57	52.74
COL3A1	-0.0009223	12325	GTEx	DepMap	Descartes	40.12	1509.56

Proteasomal degradation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this is for proteasomal degradataion:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.35e-01
Mean rank of genes in gene set: 6008.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PSMA3	0.0000404	3525	GTEx	DepMap	Descartes	0.96	164.76
PSMA4	-0.0000833	5442	GTEx	DepMap	Descartes	0.62	31.47
PSMB3	-0.0000982	5747	GTEx	DepMap	Descartes	0.66	211.24
PSME2	-0.0001755	7347	GTEx	DepMap	Descartes	0.91	70.75
PSMC2	-0.0002101	7983	GTEx	DepMap	Descartes	0.53	40.42

Mesencchymal populations mouse (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.60e-01
Mean rank of genes in gene set: 6015
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
FLI1	-0.0006229	11754	GTEx	DepMap	Descartes	0.25	6.50

SCPs neuroblastoma unique (Olsen)
Similar to above, but for genes unique to neuroblastoma SCP-like cells. Note FN1 is often used as a mesenchymal marker gene.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.04e-01
Mean rank of genes in gene set: 6290.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TIMP3	0.0045303	70	GTEx	DepMap	Descartes	20.07	1059.29
IFITM3	0.0025463	193	GTEx	DepMap	Descartes	27.97	9376.71
FN1	0.0010430	603	GTEx	DepMap	Descartes	20.12	458.37
GFRA3	-0.0007601	12102	GTEx	DepMap	Descartes	0.16	9.50
ITGB8	-0.0008698	12265	GTEx	DepMap	Descartes	0.38	5.42
ANXA1	-0.0013273	12509	GTEx	DepMap	Descartes	5.48	478.98

EpiSen (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, an epithelial senescence associated program.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.14e-01
Mean rank of genes in gene set: 6336.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AQP3	-0.0000256	4425	GTEx	DepMap	Descartes	0.25	17.84
LCN2	-0.0000300	4489	GTEx	DepMap	Descartes	0.00	0.00
SLPI	-0.0002155	8088	GTEx	DepMap	Descartes	0.00	0.00
CLDN4	-0.0002319	8345	GTEx	DepMap	Descartes	0.00	0.06

PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.49e-01
Mean rank of genes in gene set: 6385.81
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD36	0.0068212	18	GTEx	DepMap	Descartes	2.59	103.82
HIF1A	0.0014569	430	GTEx	DepMap	Descartes	3.89	238.86
CSF1	0.0013050	472	GTEx	DepMap	Descartes	2.08	122.59
STAT3	0.0006175	1014	GTEx	DepMap	Descartes	5.07	245.41
STAT6	0.0002997	1765	GTEx	DepMap	Descartes	1.31	74.92
IRF1	0.0000846	3059	GTEx	DepMap	Descartes	3.18	151.09
ARG2	-0.0001075	5951	GTEx	DepMap	Descartes	0.15	18.69
STAT1	-0.0001172	6150	GTEx	DepMap	Descartes	1.13	59.26
ARG1	-0.0001435	6678	GTEx	DepMap	Descartes	0.00	0.00
SLC27A2	-0.0002003	7809	GTEx	DepMap	Descartes	0.00	0.00
TNFRSF10B	-0.0002616	8834	GTEx	DepMap	Descartes	1.32	66.47
TGFB1	-0.0006353	11793	GTEx	DepMap	Descartes	0.71	61.47
PTGS2	-0.0006574	11856	GTEx	DepMap	Descartes	2.34	98.29
IL1B	-0.0006650	11877	GTEx	DepMap	Descartes	0.45	68.90
CD84	-0.0006916	11958	GTEx	DepMap	Descartes	0.05	2.07
ANXA1	-0.0013273	12509	GTEx	DepMap	Descartes	5.48	478.98

Mesenchymal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.50e-01
Mean rank of genes in gene set: 6501.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL6A1	0.0012291	509	GTEx	DepMap	Descartes	11.67	629.12
VIM	0.0004713	1268	GTEx	DepMap	Descartes	43.93	3612.93
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
COL3A1	-0.0009223	12325	GTEx	DepMap	Descartes	40.12	1509.56

Erythroid cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.52e-01
Mean rank of genes in gene set: 6745
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALAS2	-0.0001464	6745	GTEx	DepMap	Descartes	0	0

Adrenal cortex (Kildisiute)
Adrenal cortex markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.57e-01
Mean rank of genes in gene set: 6795
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-0.0001486	6795	GTEx	DepMap	Descartes	0.01	0.96

Adrenal gland cortex (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.57e-01
Mean rank of genes in gene set: 6795
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-0.0001486	6795	GTEx	DepMap	Descartes	0.01	0.96

Angioblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Angioblast subcluster of Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.82e-01
Mean rank of genes in gene set: 6709.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NES	0.0010924	573	GTEx	DepMap	Descartes	2.17	80.05
MAP4K4	-0.0001723	7278	GTEx	DepMap	Descartes	1.96	59.97
PREX1	-0.0008857	12278	GTEx	DepMap	Descartes	0.17	5.20

Hepatocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ALB+ Hepatocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D. The main text also speculated that these hepatocytes were probably derived from neighboring tissue, and hence artifactual, but there is no evidence presented for this.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.95e-01
Mean rank of genes in gene set: 6888.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALB	-0.0001254	6310	GTEx	DepMap	Descartes	0.00	0.42
ASGR1	-0.0001819	7467	GTEx	DepMap	Descartes	0.12	12.19

Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.12e-01
Mean rank of genes in gene set: 6561.85
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CALD1	0.0085909	8	GTEx	DepMap	Descartes	14.98	735.14
BGN	0.0040914	86	GTEx	DepMap	Descartes	25.62	2315.20
SPARC	0.0023784	209	GTEx	DepMap	Descartes	70.01	4172.72
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
COL6A2	0.0016823	364	GTEx	DepMap	Descartes	10.07	657.28
MGP	0.0001293	2688	GTEx	DepMap	Descartes	35.43	4679.43
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
COL1A1	-0.0008282	12222	GTEx	DepMap	Descartes	77.29	2593.54
LEPR	-0.0009002	12296	GTEx	DepMap	Descartes	0.16	3.81
COL3A1	-0.0009223	12325	GTEx	DepMap	Descartes	40.12	1509.56
LUM	-0.0019873	12547	GTEx	DepMap	Descartes	6.44	471.80
DCN	-0.0023171	12549	GTEx	DepMap	Descartes	10.13	309.47

Committed Progenitor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Committed Progenitor subcluster (seems to mean progenitor of chromaffin cells), which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.24e-01
Mean rank of genes in gene set: 6571.13
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS5	0.0102950	2	GTEx	DepMap	Descartes	44.82	1941.28
NDUFA4L2	0.0066761	21	GTEx	DepMap	Descartes	1.69	349.08
PARM1	0.0064975	25	GTEx	DepMap	Descartes	1.45	77.21
NTRK3	0.0021032	259	GTEx	DepMap	Descartes	1.09	13.19
UNC5C	0.0008403	760	GTEx	DepMap	Descartes	0.12	2.84
RGS4	0.0001394	2615	GTEx	DepMap	Descartes	1.13	65.45
ZDBF2	-0.0001396	6601	GTEx	DepMap	Descartes	0.36	9.42
ATP6V1B2	-0.0003451	9957	GTEx	DepMap	Descartes	2.00	60.24
NRK	-0.0003621	10149	GTEx	DepMap	Descartes	0.08	1.78
SLC18A2	-0.0003848	10378	GTEx	DepMap	Descartes	0.03	1.78
DGKK	-0.0003875	10400	GTEx	DepMap	Descartes	0.01	0.78
SYTL4	-0.0005458	11495	GTEx	DepMap	Descartes	0.15	8.92
FAM155A	-0.0006527	11838	GTEx	DepMap	Descartes	0.08	2.07
MEG3	-0.0007082	12001	GTEx	DepMap	Descartes	3.69	65.92
SYT1	-0.0007398	12066	GTEx	DepMap	Descartes	0.06	2.31

Protein maturation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.59e-01
Mean rank of genes in gene set: 7129.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDIA3	-0.0000279	4458	GTEx	DepMap	Descartes	2.20	134.21
OS9	-0.0001778	7390	GTEx	DepMap	Descartes	1.50	84.54
RPN2	-0.0003087	9540	GTEx	DepMap	Descartes	1.15	101.80

Meta_8 undefined undifferentiated neuronal (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.62e-01
Mean rank of genes in gene set: 7348
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTNNB1	0.0001825	2306	GTEx	DepMap	Descartes	2.15	99.27
SOX11	-0.0010038	12390	GTEx	DepMap	Descartes	0.26	5.54

SCPs mouse unique (Olsen)
Selected list of SCP marker genes shown in Fig. 2B of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these genes were unique to mouse SCPs as determined by the linearge tracing study Furlan et al. (Science 2017, PMID 28684471).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.63e-01
Mean rank of genes in gene set: 7035.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
H1FX	0.0003982	1424	GTEx	DepMap	Descartes	2.10	NA
CRABP1	-0.0001694	7228	GTEx	DepMap	Descartes	0.03	7.13
POSTN	-0.0002251	8252	GTEx	DepMap	Descartes	5.59	309.13
SCRG1	-0.0004978	11237	GTEx	DepMap	Descartes	0.03	1.20

Mesemchymal validated (Olsen)
Stated on pages 7 and 8 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is stated that a mesenchymal-like neuroblastoma cell state is validate by combined immunofluorescence staining for PDGFRA and FISH for PPMID gain, a gene on 17q.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.66e-01
Mean rank of genes in gene set: 7831
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62

Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.91e-01
Mean rank of genes in gene set: 6636.64
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0065880	23	GTEx	DepMap	Descartes	6.22	279.77
GPX3	0.0035062	121	GTEx	DepMap	Descartes	2.45	345.71
SERPING1	0.0019869	288	GTEx	DepMap	Descartes	7.08	797.90
IL1R1	0.0019192	303	GTEx	DepMap	Descartes	4.08	188.12
HGF	0.0018791	311	GTEx	DepMap	Descartes	0.94	40.33
CCL2	0.0010254	610	GTEx	DepMap	Descartes	26.62	7009.53
C7	0.0009667	657	GTEx	DepMap	Descartes	19.32	726.28
CXCL2	0.0007764	815	GTEx	DepMap	Descartes	23.13	4454.36
LIF	0.0007736	818	GTEx	DepMap	Descartes	4.59	256.45
CXCL12	0.0004275	1344	GTEx	DepMap	Descartes	4.84	299.67
RGMA	-0.0000408	4649	GTEx	DepMap	Descartes	0.09	2.59
CFB	-0.0001501	6823	GTEx	DepMap	Descartes	0.03	2.27
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62
IL33	-0.0003732	10270	GTEx	DepMap	Descartes	0.95	65.90
IL10	-0.0004277	10760	GTEx	DepMap	Descartes	0.03	3.84
SOD2	-0.0004644	11027	GTEx	DepMap	Descartes	10.84	177.38
IGFBP6	-0.0005514	11527	GTEx	DepMap	Descartes	0.43	81.04
SCARA3	-0.0005837	11645	GTEx	DepMap	Descartes	0.22	15.51
PDPN	-0.0006910	11955	GTEx	DepMap	Descartes	0.10	4.28
PDGFD	-0.0007561	12095	GTEx	DepMap	Descartes	0.32	15.66
CFD	-0.0007857	12149	GTEx	DepMap	Descartes	0.35	65.83
SCARA5	-0.0010170	12399	GTEx	DepMap	Descartes	0.11	6.88
CXCL14	-0.0011262	12452	GTEx	DepMap	Descartes	0.26	24.68
C3	-0.0013036	12505	GTEx	DepMap	Descartes	1.29	50.98
IGF1	-0.0016130	12539	GTEx	DepMap	Descartes	0.75	20.93

Normal Schwann cell precurors, but not Neuroblastoma Scps (Olsen)
Based on their neuroblastoma data and stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.07e-01
Mean rank of genes in gene set: 8252
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	-0.0002251	8252	GTEx	DepMap	Descartes	5.59	309.13

Myocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that MYH3+ Myocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.31e-01
Mean rank of genes in gene set: 7850
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYH3	-0.0000933	5644	GTEx	DepMap	Descartes	0.01	0.30
TTN	-0.0003525	10056	GTEx	DepMap	Descartes	0.35	0.82

Erythrocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that HBA2+ Erythrocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.49e-01
Mean rank of genes in gene set: 8706
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK1	-0.0002528	8706	GTEx	DepMap	Descartes	0.08	1.87

Bridge (Kildisiute)
Bridge cell (cites Furlan 2017) markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.63e-01
Mean rank of genes in gene set: 8865
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DLL3	-0.0002643	8865	GTEx	DepMap	Descartes	0	0.26

M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.84e-01
Mean rank of genes in gene set: 7010.07
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD36	0.0068212	18	GTEx	DepMap	Descartes	2.59	103.82
HIF1A	0.0014569	430	GTEx	DepMap	Descartes	3.89	238.86
VEGFA	0.0006290	1000	GTEx	DepMap	Descartes	4.42	86.86
STAT3	0.0006175	1014	GTEx	DepMap	Descartes	5.07	245.41
ARG2	-0.0001075	5951	GTEx	DepMap	Descartes	0.15	18.69
NOS2	-0.0001270	6348	GTEx	DepMap	Descartes	0.00	0.19
ARG1	-0.0001435	6678	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002264	8269	GTEx	DepMap	Descartes	0.29	40.08
TNFRSF10B	-0.0002616	8834	GTEx	DepMap	Descartes	1.32	66.47
CD274	-0.0002669	8901	GTEx	DepMap	Descartes	0.05	2.98
IL10	-0.0004277	10760	GTEx	DepMap	Descartes	0.03	3.84
TNF	-0.0005120	11320	GTEx	DepMap	Descartes	0.07	13.21
TGFB1	-0.0006353	11793	GTEx	DepMap	Descartes	0.71	61.47
IL1B	-0.0006650	11877	GTEx	DepMap	Descartes	0.45	68.90
CD84	-0.0006916	11958	GTEx	DepMap	Descartes	0.05	2.07

Stromal 3 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.94e-01
Mean rank of genes in gene set: 7987
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NOTCH3	0.0119134	1	GTEx	DepMap	Descartes	10.02	306.67
OLFML3	-0.0006617	11867	GTEx	DepMap	Descartes	0.79	71.11
PIK3R1	-0.0007550	12093	GTEx	DepMap	Descartes	0.86	26.80

Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.00e-01
Mean rank of genes in gene set: 8031.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IFITM3	0.0025463	193	GTEx	DepMap	Descartes	27.97	9376.71
B2M	-0.0005207	11365	GTEx	DepMap	Descartes	44.35	4154.85
S100A10	-0.0015394	12536	GTEx	DepMap	Descartes	1.33	369.40

Muscle progenitor (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PAX7+ Muscle progenitor were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.02e-01
Mean rank of genes in gene set: 8445.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PAX7	-0.0001844	7514	GTEx	DepMap	Descartes	0.00	0.21
CDON	-0.0002978	9377	GTEx	DepMap	Descartes	0.07	1.31

Mesenchymal cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that COL1A1+ Mesenchymal were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.02e-01
Mean rank of genes in gene set: 8049.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0065880	23	GTEx	DepMap	Descartes	6.22	279.77
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
COL1A1	-0.0008282	12222	GTEx	DepMap	Descartes	77.29	2593.54

Bridge region SCP-adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP-adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.13e-01
Mean rank of genes in gene set: 7884
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PCBP2	0.0001785	2331	GTEx	DepMap	Descartes	4.39	333.15
SRP14	-0.0002081	7952	GTEx	DepMap	Descartes	3.27	627.20
HMGB1	-0.0002757	9050	GTEx	DepMap	Descartes	3.20	128.79
MDK	-0.0008188	12203	GTEx	DepMap	Descartes	2.06	318.89

Pre-E Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Pre Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.15e-01
Mean rank of genes in gene set: 7211.08
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLE1	0.0012947	477	GTEx	DepMap	Descartes	0.97	62.20
LRP11	0.0004327	1333	GTEx	DepMap	Descartes	0.23	14.64
JUN	0.0000432	3490	GTEx	DepMap	Descartes	7.74	620.49
SLC31A1	0.0000431	3493	GTEx	DepMap	Descartes	0.29	13.18
PCP4	-0.0000795	5365	GTEx	DepMap	Descartes	0.01	NA
SLC38A4	-0.0001092	5993	GTEx	DepMap	Descartes	0.00	0.00
FAM163A	-0.0003284	9789	GTEx	DepMap	Descartes	0.00	0.00
ARNT2	-0.0003448	9950	GTEx	DepMap	Descartes	0.03	0.75
NELFCD	-0.0004478	10906	GTEx	DepMap	Descartes	0.33	NA
RPS6KA6	-0.0005007	11252	GTEx	DepMap	Descartes	0.02	0.56
TMX4	-0.0007658	12115	GTEx	DepMap	Descartes	0.76	24.15
ARHGEF28	-0.0009793	12370	GTEx	DepMap	Descartes	0.01	NA

Bridge region adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.15e-01
Mean rank of genes in gene set: 8151.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS5	0.0102950	2	GTEx	DepMap	Descartes	44.82	1941.28
MLLT11	-0.0007869	12152	GTEx	DepMap	Descartes	0.31	31.16
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04

Antigen Presenting CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain antigen presenting specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.30e-01
Mean rank of genes in gene set: 7272
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT18	0.0019105	305	GTEx	DepMap	Descartes	0.76	87.29
KRT8	0.0009802	647	GTEx	DepMap	Descartes	0.18	13.93
S100A3	0.0005785	1071	GTEx	DepMap	Descartes	0.03	10.35
S100A4	0.0003696	1511	GTEx	DepMap	Descartes	1.32	447.47
UPK3B	-0.0000561	4905	GTEx	DepMap	Descartes	0.00	0.00
SLPI	-0.0002155	8088	GTEx	DepMap	Descartes	0.00	0.00
S100A13	-0.0002918	9298	GTEx	DepMap	Descartes	0.47	42.84
KRT19	-0.0006502	11833	GTEx	DepMap	Descartes	0.03	4.46
CD83	-0.0007877	12154	GTEx	DepMap	Descartes	0.68	54.91
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69
CD74	-0.0015006	12529	GTEx	DepMap	Descartes	7.97	475.06
S100A10	-0.0015394	12536	GTEx	DepMap	Descartes	1.33	369.40

Inflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.32e-01
Mean rank of genes in gene set: 9767
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	-0.0003269	9767	GTEx	DepMap	Descartes	7.64	130.59

Bridge (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Bridge subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.39e-01
Mean rank of genes in gene set: 7308.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NFASC	0.0038458	101	GTEx	DepMap	Descartes	0.91	24.66
RCC2	0.0001617	2442	GTEx	DepMap	Descartes	0.96	55.64
LDHB	0.0000656	3253	GTEx	DepMap	Descartes	1.77	243.81
CKB	0.0000531	3373	GTEx	DepMap	Descartes	1.19	194.99
CDKN1C	-0.0000495	4791	GTEx	DepMap	Descartes	1.47	178.50
TBX20	-0.0001503	6828	GTEx	DepMap	Descartes	0.00	0.00
DLL3	-0.0002643	8865	GTEx	DepMap	Descartes	0.00	0.26
WDR6	-0.0002661	8890	GTEx	DepMap	Descartes	0.55	28.27
GSE1	-0.0008180	12200	GTEx	DepMap	Descartes	0.47	NA
MIAT	-0.0008461	12244	GTEx	DepMap	Descartes	0.02	0.44
DPYSL3	-0.0009229	12327	GTEx	DepMap	Descartes	0.98	36.95
SOX11	-0.0010038	12390	GTEx	DepMap	Descartes	0.26	5.54

Mesenchymal (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being expressed in a group of mesenchymal-like cells (some at least claimed to be neuroblastoma cells) shown in their UMAP representation on Fig. 1D. They reference the two Nature Genetics paper.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.61e-01
Mean rank of genes in gene set: 8238
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62
LEPR	-0.0009002	12296	GTEx	DepMap	Descartes	0.16	3.81
DCN	-0.0023171	12549	GTEx	DepMap	Descartes	10.13	309.47

M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.63e-01
Mean rank of genes in gene set: 7771.29
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VEGFA	0.0006290	1000	GTEx	DepMap	Descartes	4.42	86.86
IL13	-0.0000556	4895	GTEx	DepMap	Descartes	0.00	0.00
ARG1	-0.0001435	6678	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0002264	8269	GTEx	DepMap	Descartes	0.29	40.08
IL10	-0.0004277	10760	GTEx	DepMap	Descartes	0.03	3.84
CD163	-0.0004616	11004	GTEx	DepMap	Descartes	0.02	0.69
TGFB1	-0.0006353	11793	GTEx	DepMap	Descartes	0.71	61.47

Nerves and neurofiliment (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - NF200 is expressed in neurofiliments and is found close to SCPs in normal tissue, NRG1 is secreted by neurons, to which ERBB3 (on glia) binds.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.78e-01
Mean rank of genes in gene set: 10493
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	-0.0003954	10493	GTEx	DepMap	Descartes	0.08	1.48

Bridge region SCP-like (Olsen)
As above but for the SCP-like region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.89e-01
Mean rank of genes in gene set: 8488
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FXYD1	0.0004775	1253	GTEx	DepMap	Descartes	0.73	200.99
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
S100B	-0.0006498	11831	GTEx	DepMap	Descartes	0.72	69.83

Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.92e-01
Mean rank of genes in gene set: 7566.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IGFBP5	0.0019663	295	GTEx	DepMap	Descartes	19.38	749.19
COL14A1	0.0008376	761	GTEx	DepMap	Descartes	7.66	224.03
COL5A2	0.0003646	1532	GTEx	DepMap	Descartes	2.91	91.63
GAS1	-0.0000243	4401	GTEx	DepMap	Descartes	0.55	49.36
PENK	-0.0000908	5601	GTEx	DepMap	Descartes	0.04	9.67
POSTN	-0.0002251	8252	GTEx	DepMap	Descartes	5.59	309.13
FSTL1	-0.0002607	8817	GTEx	DepMap	Descartes	5.29	198.34
FBN1	-0.0006173	11736	GTEx	DepMap	Descartes	2.54	43.81
FBN2	-0.0006920	11959	GTEx	DepMap	Descartes	0.06	0.94
GSN	-0.0009658	12362	GTEx	DepMap	Descartes	5.18	182.79
SFRP1	-0.0015958	12537	GTEx	DepMap	Descartes	0.52	21.02
ITM2A	-0.0017185	12543	GTEx	DepMap	Descartes	0.37	36.83

B cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.05e-01
Mean rank of genes in gene set: 11025
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-0.0004643	11025	GTEx	DepMap	Descartes	0.05	6.12

Fetal Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Fetal Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.21e-01
Mean rank of genes in gene set: 11389
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRAMD1B	-0.0005261	11389	GTEx	DepMap	Descartes	0.09	2.76

Chromaffin (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. These markers are expressed at a lower level in symphathoblasts.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.35e-01
Mean rank of genes in gene set: 10143
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.10

SCPs mouse and neuroblastoma (Olsen)
Similar to above, but for genes common to neuroblastoma SCP-like cells (as determined from their UMAP plot) and mouse SCP cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.35e-01
Mean rank of genes in gene set: 7928
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DST	0.0007397	852	GTEx	DepMap	Descartes	4.22	45.42
LGI4	0.0005450	1130	GTEx	DepMap	Descartes	0.46	42.15
FXYD1	0.0004775	1253	GTEx	DepMap	Descartes	0.73	200.99
CNN3	0.0000369	3562	GTEx	DepMap	Descartes	2.41	283.82
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56
GPM6B	-0.0004941	11208	GTEx	DepMap	Descartes	0.73	28.65
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
S100B	-0.0006498	11831	GTEx	DepMap	Descartes	0.72	69.83
SEMA3B	-0.0006879	11939	GTEx	DepMap	Descartes	0.36	18.50
NRXN1	-0.0008702	12266	GTEx	DepMap	Descartes	0.13	1.64
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Symphathoadrenal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.36e-01
Mean rank of genes in gene set: 11784
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.1

Adrenergic (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for adrenergic genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.38e-01
Mean rank of genes in gene set: 10217.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03

Axon guidance (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for axon guidance instead of myelination:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.41e-01
Mean rank of genes in gene set: 11939
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SEMA3B	-0.0006879	11939	GTEx	DepMap	Descartes	0.36	18.5

Subepicardial mesenchyme (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.43e-01
Mean rank of genes in gene set: 8433.71
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
TBX18	0.0000530	3374	GTEx	DepMap	Descartes	0.22	8.93
TWIST1	-0.0002738	9015	GTEx	DepMap	Descartes	0.45	59.30
TWIST2	-0.0003413	9921	GTEx	DepMap	Descartes	0.23	31.43
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
COL1A1	-0.0008282	12222	GTEx	DepMap	Descartes	77.29	2593.54
COL3A1	-0.0009223	12325	GTEx	DepMap	Descartes	40.12	1509.56

Chromaffin cells Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for chromaffin cells (differentiating from symphathoblasts):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.47e-01
Mean rank of genes in gene set: 9646.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	-0.0000908	5601	GTEx	DepMap	Descartes	0.04	9.67
CHGB	-0.0005578	11554	GTEx	DepMap	Descartes	0.11	11.19
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.10

Cytotoxic T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.49e-01
Mean rank of genes in gene set: 12197
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93

Adrenergic neuroblatoma (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - neuroblastoma adrenergic markers derived from their data, which are state as resembling sympathoblasts and lacking chromffin markers such as PNMT:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.49e-01
Mean rank of genes in gene set: 12208
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	-0.0008216	12208	GTEx	DepMap	Descartes	0.17	20.87

Schwann cell precursors (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.52e-01
Mean rank of genes in gene set: 12299
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Schwann cell precursors (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. The authors data suggest these SCPs can give rise to symphathoblasts, which can then give rise to chromaffin cells. However, these SCPs can also directly give rise to chromaffin cells (i.e there are two bridges/paths).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.52e-01
Mean rank of genes in gene set: 12299
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Chromaffin cell-like (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 10557.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0003617	10145	GTEx	DepMap	Descartes	0.01	0.37
NPY	-0.0004566	10970	GTEx	DepMap	Descartes	0.16	67.04

Noninflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 10573
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAF	-0.0003612	10142	GTEx	DepMap	Descartes	0.80	29.91
CD163	-0.0004616	11004	GTEx	DepMap	Descartes	0.02	0.69

Adrenergic immature (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These is a marker listed for the immature adrenergic cells. SOX11 is referenced as important in early phases of pro-adrenergic differentiation (cites PMID 20147379) whereas SOX4 appears later. SOX11 is also associated with poor outcome in neuroblatoma bulk RNA-seq data (Olsen analysis).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 12390
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOX11	-0.0010038	12390	GTEx	DepMap	Descartes	0.26	5.54

Leukocyte (Kildisiute)
Leukocyes markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 12526
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.001462	12526	GTEx	DepMap	Descartes	0.2	6.67

Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.71e-01
Mean rank of genes in gene set: 11115.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
EZH2	-0.0005068	11289	GTEx	DepMap	Descartes	0.41	27.72

Adrenergic mature (olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These markers are specific to the mature adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.72e-01
Mean rank of genes in gene set: 11176.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0003617	10145	GTEx	DepMap	Descartes	0.01	0.37
GAP43	-0.0008216	12208	GTEx	DepMap	Descartes	0.17	20.87

Endothelial Cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 11342
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ENG	-0.0003608	10136	GTEx	DepMap	Descartes	3.44	227.41
VWF	-0.0020026	12548	GTEx	DepMap	Descartes	1.59	27.09

Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.81e-01
Mean rank of genes in gene set: 7951.05
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADAMTS1	0.0070995	15	GTEx	DepMap	Descartes	10.30	542.44
JAG1	0.0038137	104	GTEx	DepMap	Descartes	1.89	77.19
RHOB	0.0016074	384	GTEx	DepMap	Descartes	3.39	358.95
CLIC4	0.0011599	534	GTEx	DepMap	Descartes	3.48	181.24
THBD	0.0008245	772	GTEx	DepMap	Descartes	3.09	166.10
HES1	0.0005024	1205	GTEx	DepMap	Descartes	4.56	711.66
SPRY1	-0.0001888	7605	GTEx	DepMap	Descartes	1.73	134.22
SHROOM2	-0.0002170	8116	GTEx	DepMap	Descartes	0.10	1.79
TM4SF1	-0.0003758	10300	GTEx	DepMap	Descartes	10.74	694.81
LFNG	-0.0003782	10322	GTEx	DepMap	Descartes	0.14	10.04
CDK1	-0.0004690	11057	GTEx	DepMap	Descartes	0.05	2.84
MCF2L	-0.0005400	11460	GTEx	DepMap	Descartes	0.18	3.81
DUSP6	-0.0005871	11654	GTEx	DepMap	Descartes	3.22	163.14
IGFBP3	-0.0005971	11687	GTEx	DepMap	Descartes	1.35	121.68
MARCKSL1	-0.0006890	11945	GTEx	DepMap	Descartes	1.45	194.30
IVNS1ABP	-0.0008757	12273	GTEx	DepMap	Descartes	1.50	87.36
FAM102A	-0.0008887	12284	GTEx	DepMap	Descartes	0.32	15.77
MECOM	-0.0008930	12289	GTEx	DepMap	Descartes	0.10	3.49
GJA1	-0.0011759	12473	GTEx	DepMap	Descartes	1.38	81.33
FBLN2	-0.0017014	12542	GTEx	DepMap	Descartes	0.92	39.59

Sympathobasts or chromaffin (Kildisiute)
Sympathoblast and chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.82e-01
Mean rank of genes in gene set: 10663
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
CHGB	-0.0005578	11554	GTEx	DepMap	Descartes	0.11	11.19
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03

Neuroblastoma (Kildisiute)
Neuroblastoma markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.88e-01
Mean rank of genes in gene set: 12040.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYCN	-0.0006558	11850	GTEx	DepMap	Descartes	0.10	4.40
PHOX2A	-0.0008341	12231	GTEx	DepMap	Descartes	0.05	4.08

Schwann cell precursor (Kildisiute)
SCP markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 11055.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Schwann cell precursors (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 11055.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Neuroblastoma SCPs but not normal SCPs (Olsen)
The same as above:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 12183.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GFRA3	-0.0007601	12102	GTEx	DepMap	Descartes	0.16	9.50
ITGB8	-0.0008698	12265	GTEx	DepMap	Descartes	0.38	5.42

Immune (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Immune cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12248
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TMSB4X	-0.0007964	12174	GTEx	DepMap	Descartes	21.11	2620.17
LCP2	-0.0009215	12322	GTEx	DepMap	Descartes	0.25	10.82

Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 11167.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BCL2	-0.0003785	10325	GTEx	DepMap	Descartes	0.45	12.97
NPY	-0.0004566	10970	GTEx	DepMap	Descartes	0.16	67.04
GAP43	-0.0008216	12208	GTEx	DepMap	Descartes	0.17	20.87

Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 10544.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
UBE2C	-0.0002297	8315	GTEx	DepMap	Descartes	0.08	12.09
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
CDK1	-0.0004690	11057	GTEx	DepMap	Descartes	0.05	2.84
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Meta5 unclear (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 12315.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04
STMN1	-0.0009256	12330	GTEx	DepMap	Descartes	1.32	96.68

Immune cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRC+ Immune cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 12382
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD247	-0.0008413	12238	GTEx	DepMap	Descartes	0.04	2.62
PTPRC	-0.0014620	12526	GTEx	DepMap	Descartes	0.20	6.67

Chromaffin cell development (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12428
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HAND2	-0.0009539	12355	GTEx	DepMap	Descartes	0.1	6.55
GATA3	-0.0012853	12501	GTEx	DepMap	Descartes	0.2	11.73

Immune cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 12525.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR4	-0.0014515	12525	GTEx	DepMap	Descartes	0.85	62.32
PTPRC	-0.0014620	12526	GTEx	DepMap	Descartes	0.20	6.67

Cell cycle (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 11403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
PCNA	-0.0005284	11403	GTEx	DepMap	Descartes	0.48	65.69
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Chromaffin Cells (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: the neuronal markers NPY, PRPH, NTRK1 and ISL1 are used to annotate chromaffin cells; these were clearly expressed in neuroblasts in our analyses.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 11463.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0003617	10145	GTEx	DepMap	Descartes	0.01	0.37
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
PHOX2A	-0.0008341	12231	GTEx	DepMap	Descartes	0.05	4.08

HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.94e-01
Mean rank of genes in gene set: 11592
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD163	-0.0004616	11004	GTEx	DepMap	Descartes	0.02	0.69
AIF1	-0.0005785	11626	GTEx	DepMap	Descartes	0.04	4.48
RGS10	-0.0007856	12146	GTEx	DepMap	Descartes	0.12	29.30

Chromaffin and connecting progenitor cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 10887
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
DDC	-0.0005143	11329	GTEx	DepMap	Descartes	0.00	0.70
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.10
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03

Late chromaffin cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: this late chromaffin cell signature also includes PNMT, which is an enzyme catalyzing methylation of norepinephrine to form epinephrine; this marker is absent from the ealier less differentiated chromaffin cells (which may have been referred to as sympathoblasts in other datasets, I think):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 10887
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
DDC	-0.0005143	11329	GTEx	DepMap	Descartes	0.00	0.70
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.10
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03

Meta_7 undefined sympathetic (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 11718.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TUBB2A	-0.0005356	11439	GTEx	DepMap	Descartes	1.33	183.58
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.10
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03

Schwann cell precursor (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being characteristic of Schwann cell lineage and Furlan et al. (Science 2017, PMID 28684471) is referenced to support this. These cell types seem to be claimed to form a bridge between the mesenchymal and adrenergic cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 11897
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
S100B	-0.0006498	11831	GTEx	DepMap	Descartes	0.72	69.83
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Schwann cell precursor-like Fig 1D (Olsen)
Similar to above, but for selected SCP marker genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 11897
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
S100B	-0.0006498	11831	GTEx	DepMap	Descartes	0.72	69.83
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

Late Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: the Jansky Late Neuroblast signature is the same as the earlier Neuroblast signature, but NEFM and ALK are now absent (meaning lower expressed at later stages of differentiation):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 10733.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SYN3	-0.0001857	7538	GTEx	DepMap	Descartes	0.01	0.66
IL7	-0.0003134	9605	GTEx	DepMap	Descartes	0.03	3.49
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
GAP43	-0.0008216	12208	GTEx	DepMap	Descartes	0.17	20.87
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04

Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 12032.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KDR	-0.0005543	11538	GTEx	DepMap	Descartes	0.60	13.80
PLVAP	-0.0007343	12053	GTEx	DepMap	Descartes	2.69	175.78
PTPRB	-0.0013111	12507	GTEx	DepMap	Descartes	0.67	7.63

Endothelial cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRB+ Endothelial cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12248.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EGFL7	-0.0007648	12113	GTEx	DepMap	Descartes	0.27	20.19
FLT1	-0.0007719	12125	GTEx	DepMap	Descartes	1.68	32.25
PTPRB	-0.0013111	12507	GTEx	DepMap	Descartes	0.67	7.63

Schwann cell Precursor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the SCP subcluster, which is part of the Adrenal Medulla cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 9470.27
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LMO4	0.0009389	675	GTEx	DepMap	Descartes	2.92	145.64
DAGLA	-0.0000876	5539	GTEx	DepMap	Descartes	0.03	0.78
CNP	-0.0002403	8488	GTEx	DepMap	Descartes	0.78	31.35
TTYH1	-0.0003122	9593	GTEx	DepMap	Descartes	0.05	2.49
NGFR	-0.0003595	10127	GTEx	DepMap	Descartes	1.78	104.88
CST3	-0.0003938	10480	GTEx	DepMap	Descartes	8.27	564.22
PTPRZ1	-0.0004628	11012	GTEx	DepMap	Descartes	0.13	1.65
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
CHL1	-0.0007837	12144	GTEx	DepMap	Descartes	0.07	1.57
SERPINE2	-0.0008576	12255	GTEx	DepMap	Descartes	1.27	41.78
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27

N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 8941.94
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLCO3A1	0.0021000	260	GTEx	DepMap	Descartes	1.25	59.50
CACNA2D1	0.0007905	805	GTEx	DepMap	Descartes	0.52	16.27
LGR5	-0.0000421	4672	GTEx	DepMap	Descartes	0.00	0.08
PPFIA2	-0.0000810	5397	GTEx	DepMap	Descartes	0.04	0.98
ADCYAP1R1	-0.0001904	7632	GTEx	DepMap	Descartes	0.01	0.93
NAP1L5	-0.0002873	9231	GTEx	DepMap	Descartes	0.08	7.59
SYN2	-0.0003421	9925	GTEx	DepMap	Descartes	0.01	0.84
SCG5	-0.0003732	10269	GTEx	DepMap	Descartes	0.18	29.97
PTPRN	-0.0004692	11058	GTEx	DepMap	Descartes	0.03	1.33
GNAS	-0.0005015	11254	GTEx	DepMap	Descartes	24.95	1367.46
PCLO	-0.0006631	11872	GTEx	DepMap	Descartes	0.03	0.29
SNAP25	-0.0006886	11942	GTEx	DepMap	Descartes	0.02	0.93
CELF4	-0.0007118	12011	GTEx	DepMap	Descartes	0.06	3.58
SCG3	-0.0007721	12126	GTEx	DepMap	Descartes	0.02	1.25
C1QL1	-0.0007925	12165	GTEx	DepMap	Descartes	0.06	10.66
CXCL14	-0.0011262	12452	GTEx	DepMap	Descartes	0.26	24.68

E Chromaffin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 10675
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK3	-0.0002069	7928	GTEx	DepMap	Descartes	0.52	6.70
DLK1	-0.0003053	9491	GTEx	DepMap	Descartes	0.05	2.73
NPY	-0.0004566	10970	GTEx	DepMap	Descartes	0.16	67.04
RAB3B	-0.0005185	11351	GTEx	DepMap	Descartes	0.03	0.43
RAB3C	-0.0007514	12085	GTEx	DepMap	Descartes	0.00	0.00
GATA2	-0.0008292	12225	GTEx	DepMap	Descartes	0.24	14.72

Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 9529.09
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS5	0.0102950	2	GTEx	DepMap	Descartes	44.82	1941.28
MAP1B	0.0017661	338	GTEx	DepMap	Descartes	10.79	216.84
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
NRG1	-0.0003954	10493	GTEx	DepMap	Descartes	0.08	1.48
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
MLLT11	-0.0007869	12152	GTEx	DepMap	Descartes	0.31	31.16
RTN1	-0.0008893	12285	GTEx	DepMap	Descartes	0.14	8.80
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04
ELAVL4	-0.0009854	12374	GTEx	DepMap	Descartes	0.07	2.60
UCHL1	-0.0010747	12425	GTEx	DepMap	Descartes	0.53	57.46

Schwann cell precursor Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454). These genes were used to show cells transitioning from a SCP to a symphathoblast state in their human fetal single-cell RNA-seq data.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 9787.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL2A1	0.0004863	1234	GTEx	DepMap	Descartes	0.03	2.13
POSTN	-0.0002251	8252	GTEx	DepMap	Descartes	5.59	309.13
MOXD1	-0.0002449	8584	GTEx	DepMap	Descartes	0.38	23.42
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56
NGFR	-0.0003595	10127	GTEx	DepMap	Descartes	1.78	104.88
ERBB3	-0.0005597	11561	GTEx	DepMap	Descartes	0.17	3.71
S100B	-0.0006498	11831	GTEx	DepMap	Descartes	0.72	69.83
MBP	-0.0007933	12167	GTEx	DepMap	Descartes	0.19	4.38
PLP1	-0.0009034	12299	GTEx	DepMap	Descartes	0.26	9.27
GAS7	-0.0013688	12516	GTEx	DepMap	Descartes	0.38	6.75

Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 10550.29
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SYN3	-0.0001857	7538	GTEx	DepMap	Descartes	0.01	0.66
IL7	-0.0003134	9605	GTEx	DepMap	Descartes	0.03	3.49
ALK	-0.0003394	9899	GTEx	DepMap	Descartes	0.02	0.44
NEFM	-0.0003743	10286	GTEx	DepMap	Descartes	0.15	8.78
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
GAP43	-0.0008216	12208	GTEx	DepMap	Descartes	0.17	20.87
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04

M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 9727.91
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL2	0.0010254	610	GTEx	DepMap	Descartes	26.62	7009.53
CD80	-0.0002039	7872	GTEx	DepMap	Descartes	0.03	2.15
CD14	-0.0002264	8269	GTEx	DepMap	Descartes	0.29	40.08
IL33	-0.0003732	10270	GTEx	DepMap	Descartes	0.95	65.90
TLR4	-0.0003830	10362	GTEx	DepMap	Descartes	0.09	0.99
IL18	-0.0004618	11005	GTEx	DepMap	Descartes	0.02	1.85
TNF	-0.0005120	11320	GTEx	DepMap	Descartes	0.07	13.21
CXCL16	-0.0005420	11475	GTEx	DepMap	Descartes	0.26	21.39
ITGAX	-0.0005596	11560	GTEx	DepMap	Descartes	0.05	1.89
IL1B	-0.0006650	11877	GTEx	DepMap	Descartes	0.45	68.90
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69

Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12074.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KDR	-0.0005543	11538	GTEx	DepMap	Descartes	0.60	13.80
EGFL7	-0.0007648	12113	GTEx	DepMap	Descartes	0.27	20.19
FLT1	-0.0007719	12125	GTEx	DepMap	Descartes	1.68	32.25
PRCP	-0.0014356	12523	GTEx	DepMap	Descartes	0.70	16.53

Symphathoblasts (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. Several of these markers are also (more weakly) expressed in chromaffin cells. The authors data suggest Symphthoblasts give rise to chromaffin cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12250
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04
ELAVL3	-0.0009130	12310	GTEx	DepMap	Descartes	0.28	12.51
ELAVL4	-0.0009854	12374	GTEx	DepMap	Descartes	0.07	2.60

Broad sympathetic marker (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11511.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
CHGB	-0.0005578	11554	GTEx	DepMap	Descartes	0.11	11.19
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03
GATA2	-0.0008292	12225	GTEx	DepMap	Descartes	0.24	14.72
HAND2	-0.0009539	12355	GTEx	DepMap	Descartes	0.10	6.55
GATA3	-0.0012853	12501	GTEx	DepMap	Descartes	0.20	11.73

Symphathoblasts Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for symphathoblasts (differentiating from SCPs):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12117
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ELAVL2	-0.0005553	11540	GTEx	DepMap	Descartes	0.02	1.33
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04
HAND2	-0.0009539	12355	GTEx	DepMap	Descartes	0.10	6.55
ELAVL4	-0.0009854	12374	GTEx	DepMap	Descartes	0.07	2.60

Other T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11694.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-0.0003146	9626	GTEx	DepMap	Descartes	0.02	1.24
CD4	-0.0005388	11452	GTEx	DepMap	Descartes	0.29	20.47
CCR7	-0.0007364	12058	GTEx	DepMap	Descartes	0.20	12.69
LEF1	-0.0008456	12242	GTEx	DepMap	Descartes	0.19	9.02
SELL	-0.0010072	12394	GTEx	DepMap	Descartes	0.17	8.88
TCF7	-0.0010126	12396	GTEx	DepMap	Descartes	0.15	4.30

Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10811.69
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAP1B	0.0017661	338	GTEx	DepMap	Descartes	10.79	216.84
TH	-0.0002411	8502	GTEx	DepMap	Descartes	0.09	11.14
DISP2	-0.0003094	9552	GTEx	DepMap	Descartes	0.03	0.45
SLC18A1	-0.0003682	10219	GTEx	DepMap	Descartes	0.01	0.41
DDC	-0.0005143	11329	GTEx	DepMap	Descartes	0.00	0.70
CHGB	-0.0005578	11554	GTEx	DepMap	Descartes	0.11	11.19
CHGA	-0.0006318	11784	GTEx	DepMap	Descartes	0.46	54.10
DBH	-0.0006850	11933	GTEx	DepMap	Descartes	0.04	4.03
EML5	-0.0007049	11995	GTEx	DepMap	Descartes	0.02	0.81
NNAT	-0.0007104	12007	GTEx	DepMap	Descartes	0.16	33.25
PCSK1N	-0.0007678	12119	GTEx	DepMap	Descartes	0.18	45.53
CYB561	-0.0007827	12143	GTEx	DepMap	Descartes	0.18	13.80
PHOX2A	-0.0008341	12231	GTEx	DepMap	Descartes	0.05	4.08
HAND2	-0.0009539	12355	GTEx	DepMap	Descartes	0.10	6.55
UCHL1	-0.0010747	12425	GTEx	DepMap	Descartes	0.53	57.46
GATA3	-0.0012853	12501	GTEx	DepMap	Descartes	0.20	11.73

Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11812.45
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCND1	-0.0003466	9979	GTEx	DepMap	Descartes	2.23	89.06
NEFM	-0.0003743	10286	GTEx	DepMap	Descartes	0.15	8.78
NEFL	-0.0005234	11383	GTEx	DepMap	Descartes	0.02	0.86
ISL1	-0.0007150	12015	GTEx	DepMap	Descartes	0.13	10.62
RTN1	-0.0008893	12285	GTEx	DepMap	Descartes	0.14	8.80
STMN2	-0.0009044	12301	GTEx	DepMap	Descartes	0.19	20.04
BASP1	-0.0009084	12305	GTEx	DepMap	Descartes	1.73	192.41
ELAVL3	-0.0009130	12310	GTEx	DepMap	Descartes	0.28	12.51
STMN1	-0.0009256	12330	GTEx	DepMap	Descartes	1.32	96.68
INA	-0.0009783	12369	GTEx	DepMap	Descartes	0.25	14.85
ELAVL4	-0.0009854	12374	GTEx	DepMap	Descartes	0.07	2.60

Plasmacytoid dendritic cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Adrenal Cortex (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Symphatoblasts (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: Sympathoblasts were identified by Dong et al.28 based on the expression of CARTPT and INSM1, which we found expressed in chromaffin cells:
Autonomic neurons mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Erythroblast (Kildisiute)
Erythroblast markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Chromaffin (Kildisiute)
Chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Cortex (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for their broad Cortex group, which is composed of Fetal Zone, Definitive Zone and Adr Primordium subclusters:
Adrenal cortical (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that CYP11A1+ Adrenal cortical cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:

Below shows ranks on this GEP for literature curated gene lists for large gene sets
These include those reported as mesenchymal/adrenergic by Van Groningen et al.
High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9046.73
Median rank of genes in gene set: 10656
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
RGS5	0.0102950	2	GTEx	DepMap	Descartes	44.82	1941.28
SYNPO2	0.0066564	22	GTEx	DepMap	Descartes	3.30	62.60
SLIT3	0.0048546	56	GTEx	DepMap	Descartes	4.70	121.84
NFIL3	0.0033523	128	GTEx	DepMap	Descartes	3.05	399.31
AKAP12	0.0020569	272	GTEx	DepMap	Descartes	4.70	134.74
CYGB	0.0020502	273	GTEx	DepMap	Descartes	2.18	245.18
KLHL23	0.0020254	280	GTEx	DepMap	Descartes	0.50	31.44
MAP1B	0.0017661	338	GTEx	DepMap	Descartes	10.79	216.84
NET1	0.0015327	405	GTEx	DepMap	Descartes	0.88	59.35
FOXO3	0.0012009	519	GTEx	DepMap	Descartes	3.45	116.88
ARHGEF7	0.0011721	528	GTEx	DepMap	Descartes	1.36	67.69
EIF1B	0.0010673	582	GTEx	DepMap	Descartes	2.31	562.53
MXI1	0.0010582	590	GTEx	DepMap	Descartes	0.93	67.24
TUBB4B	0.0009574	665	GTEx	DepMap	Descartes	3.37	394.93
RBP1	0.0008044	791	GTEx	DepMap	Descartes	0.96	114.79
TACC2	0.0005882	1059	GTEx	DepMap	Descartes	0.24	5.06
AKAP1	0.0005351	1151	GTEx	DepMap	Descartes	0.47	30.30
RNF150	0.0004587	1284	GTEx	DepMap	Descartes	0.38	7.81
HEY1	0.0004264	1346	GTEx	DepMap	Descartes	0.66	32.21
NCS1	0.0004061	1400	GTEx	DepMap	Descartes	0.49	21.68
TMEM108	0.0004021	1416	GTEx	DepMap	Descartes	0.08	4.33
MAP2	0.0004010	1420	GTEx	DepMap	Descartes	0.55	13.81
H1FX	0.0003982	1424	GTEx	DepMap	Descartes	2.10	NA
RAB33A	0.0003184	1694	GTEx	DepMap	Descartes	0.29	60.84
MAGI3	0.0003182	1697	GTEx	DepMap	Descartes	0.35	10.87
NMNAT2	0.0002934	1790	GTEx	DepMap	Descartes	0.12	4.78
KLF13	0.0002398	2012	GTEx	DepMap	Descartes	1.66	56.12
SERP2	0.0001983	2213	GTEx	DepMap	Descartes	0.05	14.74
PHPT1	0.0001932	2245	GTEx	DepMap	Descartes	0.46	81.99
SETD7	0.0001606	2452	GTEx	DepMap	Descartes	0.83	23.61

VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.12e-16
Mean rank of genes in gene set: 4912.57
Median rank of genes in gene set: 3086
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ACTA2	0.0102396	3	GTEx	DepMap	Descartes	25.28	4742.88
CALD1	0.0085909	8	GTEx	DepMap	Descartes	14.98	735.14
TPM2	0.0081341	9	GTEx	DepMap	Descartes	6.11	1005.19
COL4A1	0.0070518	16	GTEx	DepMap	Descartes	16.86	540.87
COL4A2	0.0067010	20	GTEx	DepMap	Descartes	21.16	681.46
TPM1	0.0065753	24	GTEx	DepMap	Descartes	7.28	442.76
LPP	0.0062298	28	GTEx	DepMap	Descartes	7.26	102.73
FILIP1L	0.0060749	31	GTEx	DepMap	Descartes	5.32	347.43
TNS1	0.0051181	49	GTEx	DepMap	Descartes	4.67	114.91
SPARCL1	0.0047122	60	GTEx	DepMap	Descartes	8.55	716.85
EDNRA	0.0046726	61	GTEx	DepMap	Descartes	1.75	110.87
EPS8	0.0045150	71	GTEx	DepMap	Descartes	3.21	166.21
PDE3A	0.0043605	75	GTEx	DepMap	Descartes	1.34	44.22
EHD2	0.0041645	82	GTEx	DepMap	Descartes	1.90	137.54
VCL	0.0041118	84	GTEx	DepMap	Descartes	4.04	119.41
BGN	0.0040914	86	GTEx	DepMap	Descartes	25.62	2315.20
KANK2	0.0040413	88	GTEx	DepMap	Descartes	2.35	102.17
SNAI2	0.0037436	105	GTEx	DepMap	Descartes	3.30	263.83
ERRFI1	0.0037385	106	GTEx	DepMap	Descartes	7.31	584.05
TNC	0.0035879	114	GTEx	DepMap	Descartes	4.52	126.72
CSRP1	0.0035788	115	GTEx	DepMap	Descartes	4.35	126.81
PALLD	0.0035661	117	GTEx	DepMap	Descartes	4.56	189.07
A2M	0.0035273	119	GTEx	DepMap	Descartes	9.89	505.96
S1PR3	0.0032165	136	GTEx	DepMap	Descartes	4.42	117.09
ACTN1	0.0028632	162	GTEx	DepMap	Descartes	6.89	354.52
TGFB1I1	0.0028545	163	GTEx	DepMap	Descartes	1.24	59.81
ITGB1	0.0028444	164	GTEx	DepMap	Descartes	4.43	255.42
PLS3	0.0028073	165	GTEx	DepMap	Descartes	1.95	142.21
SDC2	0.0025839	186	GTEx	DepMap	Descartes	2.98	220.48
FLNA	0.0025813	187	GTEx	DepMap	Descartes	6.93	208.55

Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.94e-01
Mean rank of genes in gene set: 7784.78
Median rank of genes in gene set: 8405.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
LDLR	0.0008794	728	GTEx	DepMap	Descartes	1.89	87.90
PAPSS2	0.0005193	1178	GTEx	DepMap	Descartes	0.68	37.22
IGF1R	0.0003366	1621	GTEx	DepMap	Descartes	0.70	13.80
PDE10A	0.0002723	1858	GTEx	DepMap	Descartes	0.18	4.18
POR	0.0000347	3589	GTEx	DepMap	Descartes	0.52	47.19
SGCZ	0.0000323	3618	GTEx	DepMap	Descartes	0.00	0.00
GSTA4	0.0000044	3984	GTEx	DepMap	Descartes	0.26	34.05
BAIAP2L1	-0.0000446	4716	GTEx	DepMap	Descartes	0.05	3.08
FDPS	-0.0000489	4780	GTEx	DepMap	Descartes	0.52	57.86
FDXR	-0.0000793	5362	GTEx	DepMap	Descartes	0.03	2.10
SH3PXD2B	-0.0000858	5497	GTEx	DepMap	Descartes	0.23	7.17
SLC16A9	-0.0000962	5703	GTEx	DepMap	Descartes	0.06	3.68
INHA	-0.0001155	6114	GTEx	DepMap	Descartes	0.00	0.39
FDX1	-0.0001193	6191	GTEx	DepMap	Descartes	0.28	18.96
STAR	-0.0001486	6795	GTEx	DepMap	Descartes	0.01	0.96
FREM2	-0.0001876	7582	GTEx	DepMap	Descartes	0.01	0.05
TM7SF2	-0.0001925	7666	GTEx	DepMap	Descartes	0.04	3.84
NPC1	-0.0002351	8397	GTEx	DepMap	Descartes	0.37	21.50
SCAP	-0.0002358	8414	GTEx	DepMap	Descartes	0.16	9.08
DHCR24	-0.0002449	8585	GTEx	DepMap	Descartes	0.11	5.48
APOC1	-0.0002515	8688	GTEx	DepMap	Descartes	0.38	135.66
ERN1	-0.0003212	9704	GTEx	DepMap	Descartes	0.58	15.17
SLC1A2	-0.0003456	9962	GTEx	DepMap	Descartes	0.02	0.44
DNER	-0.0004143	10649	GTEx	DepMap	Descartes	0.00	0.48
CYB5B	-0.0004171	10673	GTEx	DepMap	Descartes	0.41	20.44
DHCR7	-0.0004211	10705	GTEx	DepMap	Descartes	0.05	2.72
FRMD5	-0.0004764	11106	GTEx	DepMap	Descartes	0.05	1.33
GRAMD1B	-0.0005261	11389	GTEx	DepMap	Descartes	0.09	2.76
SCARB1	-0.0005265	11391	GTEx	DepMap	Descartes	0.12	3.83
JAKMIP2	-0.0005881	11655	GTEx	DepMap	Descartes	0.02	0.43

Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9214.88
Median rank of genes in gene set: 10274
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
SYNPO2	0.0066564	22	GTEx	DepMap	Descartes	3.30	62.60
MAP1B	0.0017661	338	GTEx	DepMap	Descartes	10.79	216.84
FAT3	0.0009911	644	GTEx	DepMap	Descartes	0.14	1.95
RYR2	0.0005196	1177	GTEx	DepMap	Descartes	0.11	1.51
GAL	-0.0000806	5386	GTEx	DepMap	Descartes	0.04	10.91
EPHA6	-0.0000985	5757	GTEx	DepMap	Descartes	0.00	0.00
REEP1	-0.0001029	5849	GTEx	DepMap	Descartes	0.06	4.06
ANKFN1	-0.0002002	7807	GTEx	DepMap	Descartes	0.00	0.00
KCNB2	-0.0002034	7864	GTEx	DepMap	Descartes	0.00	0.17
RPH3A	-0.0002324	8358	GTEx	DepMap	Descartes	0.01	0.38
RGMB	-0.0002410	8500	GTEx	DepMap	Descartes	0.48	22.61
HS3ST5	-0.0002422	8523	GTEx	DepMap	Descartes	0.01	0.56
TMEFF2	-0.0002612	8822	GTEx	DepMap	Descartes	0.00	0.00
SLC44A5	-0.0002632	8855	GTEx	DepMap	Descartes	0.01	0.61
EYA4	-0.0002717	8983	GTEx	DepMap	Descartes	0.01	0.13
IL7	-0.0003134	9605	GTEx	DepMap	Descartes	0.03	3.49
GREM1	-0.0003373	9874	GTEx	DepMap	Descartes	1.51	14.98
ALK	-0.0003394	9899	GTEx	DepMap	Descartes	0.02	0.44
CCND1	-0.0003466	9979	GTEx	DepMap	Descartes	2.23	89.06
NTRK1	-0.0003617	10145	GTEx	DepMap	Descartes	0.01	0.37
PTCHD1	-0.0003733	10274	GTEx	DepMap	Descartes	0.02	0.44
EYA1	-0.0003959	10498	GTEx	DepMap	Descartes	0.00	0.04
RBFOX1	-0.0004075	10588	GTEx	DepMap	Descartes	0.00	0.07
CNTFR	-0.0004302	10784	GTEx	DepMap	Descartes	0.01	0.73
PLXNA4	-0.0004401	10855	GTEx	DepMap	Descartes	0.02	0.27
NPY	-0.0004566	10970	GTEx	DepMap	Descartes	0.16	67.04
MAB21L2	-0.0004971	11233	GTEx	DepMap	Descartes	0.09	10.99
SLC6A2	-0.0004984	11240	GTEx	DepMap	Descartes	0.03	1.13
TUBA1A	-0.0005132	11325	GTEx	DepMap	Descartes	6.79	834.95
TUBB2A	-0.0005356	11439	GTEx	DepMap	Descartes	1.33	183.58

Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9411.55
Median rank of genes in gene set: 11685
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CYP26B1	0.0010173	614	GTEx	DepMap	Descartes	0.44	20.52
EHD3	0.0009376	676	GTEx	DepMap	Descartes	0.25	11.92
CDH13	0.0008620	740	GTEx	DepMap	Descartes	0.58	14.11
ARHGAP29	0.0007579	836	GTEx	DepMap	Descartes	0.85	21.82
ID1	0.0005400	1141	GTEx	DepMap	Descartes	1.65	380.59
IRX3	0.0000949	2957	GTEx	DepMap	Descartes	0.07	5.25
BTNL9	-0.0000223	4377	GTEx	DepMap	Descartes	0.23	8.02
TMEM88	-0.0000810	5396	GTEx	DepMap	Descartes	0.43	86.54
CHRM3	-0.0000991	5774	GTEx	DepMap	Descartes	0.03	0.83
CRHBP	-0.0002105	7990	GTEx	DepMap	Descartes	0.00	0.00
CEACAM1	-0.0002727	9000	GTEx	DepMap	Descartes	0.16	8.48
NR5A2	-0.0002799	9125	GTEx	DepMap	Descartes	0.03	0.86
EFNB2	-0.0003166	9652	GTEx	DepMap	Descartes	1.10	45.10
NPR1	-0.0003760	10303	GTEx	DepMap	Descartes	0.08	2.49
NOTCH4	-0.0004422	10870	GTEx	DepMap	Descartes	0.45	9.41
RASIP1	-0.0004928	11201	GTEx	DepMap	Descartes	0.26	12.69
KANK3	-0.0005214	11372	GTEx	DepMap	Descartes	0.20	10.56
KDR	-0.0005543	11538	GTEx	DepMap	Descartes	0.60	13.80
ESM1	-0.0005559	11546	GTEx	DepMap	Descartes	0.79	49.63
F8	-0.0006478	11824	GTEx	DepMap	Descartes	0.12	2.06
GALNT15	-0.0006514	11836	GTEx	DepMap	Descartes	0.05	NA
SHE	-0.0006571	11855	GTEx	DepMap	Descartes	0.17	4.43
CLDN5	-0.0006848	11931	GTEx	DepMap	Descartes	0.37	26.50
HYAL2	-0.0007198	12026	GTEx	DepMap	Descartes	0.26	10.16
PLVAP	-0.0007343	12053	GTEx	DepMap	Descartes	2.69	175.78
PODXL	-0.0008018	12180	GTEx	DepMap	Descartes	0.72	17.29
MMRN2	-0.0008624	12258	GTEx	DepMap	Descartes	0.41	13.04
ROBO4	-0.0008863	12279	GTEx	DepMap	Descartes	0.32	10.34
SHANK3	-0.0008997	12294	GTEx	DepMap	Descartes	0.67	11.71
FLT4	-0.0009887	12377	GTEx	DepMap	Descartes	0.15	3.28

Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.47e-01
Mean rank of genes in gene set: 6833.75
Median rank of genes in gene set: 8130.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ACTA2	0.0102396	3	GTEx	DepMap	Descartes	25.28	4742.88
ABCC9	0.0057510	36	GTEx	DepMap	Descartes	2.17	71.55
EDNRA	0.0046726	61	GTEx	DepMap	Descartes	1.75	110.87
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
CD248	0.0018124	325	GTEx	DepMap	Descartes	0.83	60.32
COL27A1	0.0016584	371	GTEx	DepMap	Descartes	1.00	31.99
COL12A1	0.0014977	417	GTEx	DepMap	Descartes	3.95	74.59
PCDH18	0.0012894	482	GTEx	DepMap	Descartes	0.61	26.70
ADAMTS2	0.0010828	577	GTEx	DepMap	Descartes	1.55	49.80
ITGA11	0.0010078	627	GTEx	DepMap	Descartes	0.68	15.67
C7	0.0009667	657	GTEx	DepMap	Descartes	19.32	726.28
COL6A3	0.0008006	794	GTEx	DepMap	Descartes	7.48	150.71
ADAMTSL3	0.0007426	848	GTEx	DepMap	Descartes	0.37	12.87
CDH11	0.0004977	1216	GTEx	DepMap	Descartes	1.39	42.23
LRRC17	0.0003485	1589	GTEx	DepMap	Descartes	0.30	32.05
GLI2	0.0001670	2407	GTEx	DepMap	Descartes	0.11	4.30
LAMC3	0.0001368	2639	GTEx	DepMap	Descartes	0.10	3.36
MGP	0.0001293	2688	GTEx	DepMap	Descartes	35.43	4679.43
PCOLCE	-0.0000709	5201	GTEx	DepMap	Descartes	3.16	448.19
GAS2	-0.0001114	6040	GTEx	DepMap	Descartes	0.00	0.49
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62
PAMR1	-0.0002133	8043	GTEx	DepMap	Descartes	0.48	24.66
ELN	-0.0002229	8218	GTEx	DepMap	Descartes	2.51	144.81
POSTN	-0.0002251	8252	GTEx	DepMap	Descartes	5.59	309.13
DKK2	-0.0004247	10738	GTEx	DepMap	Descartes	0.04	1.79
FREM1	-0.0004642	11021	GTEx	DepMap	Descartes	0.03	0.81
RSPO3	-0.0005190	11354	GTEx	DepMap	Descartes	0.05	NA
CLDN11	-0.0005572	11553	GTEx	DepMap	Descartes	0.15	10.41
IGFBP3	-0.0005971	11687	GTEx	DepMap	Descartes	1.35	121.68
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37

Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7950.66
Median rank of genes in gene set: 7866
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
LAMA3	0.0017130	350	GTEx	DepMap	Descartes	0.31	7.57
ROBO1	0.0006142	1022	GTEx	DepMap	Descartes	0.42	12.74
SLC35F3	0.0000113	3874	GTEx	DepMap	Descartes	0.01	0.36
AGBL4	-0.0000343	4556	GTEx	DepMap	Descartes	0.01	0.64
GRM7	-0.0000574	4935	GTEx	DepMap	Descartes	0.00	0.12
PACRG	-0.0000587	4959	GTEx	DepMap	Descartes	0.01	0.48
SLC24A2	-0.0000608	5005	GTEx	DepMap	Descartes	0.01	0.17
EML6	-0.0000781	5334	GTEx	DepMap	Descartes	0.04	1.10
SPOCK3	-0.0000837	5450	GTEx	DepMap	Descartes	0.00	0.00
PENK	-0.0000908	5601	GTEx	DepMap	Descartes	0.04	9.67
CDH18	-0.0000914	5614	GTEx	DepMap	Descartes	0.00	0.00
HTATSF1	-0.0001045	5887	GTEx	DepMap	Descartes	0.45	33.49
SORCS3	-0.0001327	6462	GTEx	DepMap	Descartes	0.00	0.39
GALNTL6	-0.0001374	6554	GTEx	DepMap	Descartes	0.00	0.06
CDH12	-0.0001431	6666	GTEx	DepMap	Descartes	0.00	0.00
GRID2	-0.0001462	6743	GTEx	DepMap	Descartes	0.00	0.07
TBX20	-0.0001503	6828	GTEx	DepMap	Descartes	0.00	0.00
ARC	-0.0001850	7525	GTEx	DepMap	Descartes	1.24	100.32
KSR2	-0.0001877	7583	GTEx	DepMap	Descartes	0.00	0.05
PCSK2	-0.0002188	8149	GTEx	DepMap	Descartes	0.18	5.61
CCSER1	-0.0002380	8446	GTEx	DepMap	Descartes	0.00	NA
ST18	-0.0002387	8463	GTEx	DepMap	Descartes	0.01	0.48
FGF14	-0.0002665	8894	GTEx	DepMap	Descartes	0.05	0.93
MGAT4C	-0.0002740	9022	GTEx	DepMap	Descartes	0.01	0.08
CNTN3	-0.0003670	10204	GTEx	DepMap	Descartes	0.01	0.70
SLC18A1	-0.0003682	10219	GTEx	DepMap	Descartes	0.01	0.41
DGKK	-0.0003875	10400	GTEx	DepMap	Descartes	0.01	0.78
KCTD16	-0.0003886	10412	GTEx	DepMap	Descartes	0.01	0.24
NTNG1	-0.0004115	10618	GTEx	DepMap	Descartes	0.01	0.44
TENM1	-0.0004701	11064	GTEx	DepMap	Descartes	0.01	NA

Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.76e-01
Mean rank of genes in gene set: 5649.55
Median rank of genes in gene set: 5113
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
SELENBP1	0.0021371	251	GTEx	DepMap	Descartes	0.61	51.82
MICAL2	0.0018083	326	GTEx	DepMap	Descartes	3.09	106.21
SPECC1	0.0016962	356	GTEx	DepMap	Descartes	0.43	14.48
SPTB	0.0010963	569	GTEx	DepMap	Descartes	0.06	1.45
RGS6	0.0007315	864	GTEx	DepMap	Descartes	0.04	3.49
RAPGEF2	0.0005433	1134	GTEx	DepMap	Descartes	1.34	35.25
CAT	0.0004962	1218	GTEx	DepMap	Descartes	0.55	58.20
TRAK2	0.0002626	1901	GTEx	DepMap	Descartes	0.43	15.89
BLVRB	0.0000462	3450	GTEx	DepMap	Descartes	0.24	39.45
SLC25A21	0.0000361	3571	GTEx	DepMap	Descartes	0.00	0.40
SOX6	0.0000307	3633	GTEx	DepMap	Descartes	0.21	6.76
ABCB10	0.0000007	4044	GTEx	DepMap	Descartes	0.15	8.54
RHD	-0.0000020	4086	GTEx	DepMap	Descartes	0.01	0.46
TMCC2	-0.0000593	4976	GTEx	DepMap	Descartes	0.05	7.20
TFR2	-0.0000666	5113	GTEx	DepMap	Descartes	0.01	1.24
MARCH3	-0.0000927	5635	GTEx	DepMap	Descartes	0.45	NA
ALAS2	-0.0001464	6745	GTEx	DepMap	Descartes	0.00	0.00
SLC4A1	-0.0001854	7531	GTEx	DepMap	Descartes	0.01	0.12
SLC25A37	-0.0001866	7562	GTEx	DepMap	Descartes	1.06	56.26
XPO7	-0.0001989	7776	GTEx	DepMap	Descartes	0.26	12.65
GCLC	-0.0002414	8507	GTEx	DepMap	Descartes	0.25	15.29
CPOX	-0.0002504	8669	GTEx	DepMap	Descartes	0.09	7.37
ANK1	-0.0002528	8706	GTEx	DepMap	Descartes	0.08	1.87
FECH	-0.0003253	9752	GTEx	DepMap	Descartes	0.06	1.78
DENND4A	-0.0004296	10777	GTEx	DepMap	Descartes	0.92	23.77
GYPC	-0.0004837	11143	GTEx	DepMap	Descartes	0.62	72.75
TSPAN5	-0.0005421	11476	GTEx	DepMap	Descartes	0.34	17.75
SNCA	-0.0006603	11861	GTEx	DepMap	Descartes	0.03	1.35
EPB41	-0.0008203	12205	GTEx	DepMap	Descartes	0.08	2.42
NA	NA	NA	NA	NA	NA	NA	NA

Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8418.37
Median rank of genes in gene set: 10296
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
AXL	0.0030192	151	GTEx	DepMap	Descartes	2.21	121.35
ADAP2	0.0008944	716	GTEx	DepMap	Descartes	0.23	21.35
TGFBI	0.0003240	1667	GTEx	DepMap	Descartes	3.46	172.59
MERTK	0.0002974	1777	GTEx	DepMap	Descartes	0.16	11.34
CTSC	0.0002889	1807	GTEx	DepMap	Descartes	1.86	75.44
LGMN	0.0001688	2392	GTEx	DepMap	Descartes	1.27	142.20
IFNGR1	0.0001103	2820	GTEx	DepMap	Descartes	0.60	54.80
HRH1	-0.0000121	4221	GTEx	DepMap	Descartes	0.31	13.42
CTSD	-0.0000598	4984	GTEx	DepMap	Descartes	2.85	285.62
ABCA1	-0.0001043	5883	GTEx	DepMap	Descartes	1.27	28.15
CD163L1	-0.0001085	5977	GTEx	DepMap	Descartes	0.02	0.95
ATP8B4	-0.0001737	7311	GTEx	DepMap	Descartes	0.03	1.14
SPP1	-0.0001767	7369	GTEx	DepMap	Descartes	0.20	12.10
FGD2	-0.0002214	8189	GTEx	DepMap	Descartes	0.01	1.06
CD14	-0.0002264	8269	GTEx	DepMap	Descartes	0.29	40.08
SLC9A9	-0.0002658	8885	GTEx	DepMap	Descartes	0.14	8.03
CSF1R	-0.0002884	9249	GTEx	DepMap	Descartes	0.08	3.84
RBPJ	-0.0003648	10179	GTEx	DepMap	Descartes	1.76	64.52
PTPRE	-0.0003692	10227	GTEx	DepMap	Descartes	1.16	42.47
MS4A4A	-0.0003835	10365	GTEx	DepMap	Descartes	0.01	1.53
CST3	-0.0003938	10480	GTEx	DepMap	Descartes	8.27	564.22
ITPR2	-0.0004176	10678	GTEx	DepMap	Descartes	0.42	7.01
MARCH1	-0.0004471	10902	GTEx	DepMap	Descartes	0.02	NA
MSR1	-0.0004612	11000	GTEx	DepMap	Descartes	0.02	0.93
CD163	-0.0004616	11004	GTEx	DepMap	Descartes	0.02	0.69
FMN1	-0.0005045	11268	GTEx	DepMap	Descartes	0.05	0.37
CPVL	-0.0005174	11345	GTEx	DepMap	Descartes	0.07	6.47
CYBB	-0.0005260	11388	GTEx	DepMap	Descartes	0.02	0.88
SLC1A3	-0.0005318	11421	GTEx	DepMap	Descartes	0.05	1.78
HCK	-0.0005461	11498	GTEx	DepMap	Descartes	0.02	2.78

Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.17e-01
Mean rank of genes in gene set: 6298.84
Median rank of genes in gene set: 6932.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
COL18A1	0.0071299	13	GTEx	DepMap	Descartes	8.32	294.98
EDNRB	0.0053267	45	GTEx	DepMap	Descartes	2.52	128.06
OLFML2A	0.0022911	224	GTEx	DepMap	Descartes	1.62	59.55
EGFLAM	0.0021635	240	GTEx	DepMap	Descartes	0.70	39.56
LAMC1	0.0020135	282	GTEx	DepMap	Descartes	4.95	145.05
PLCE1	0.0018077	327	GTEx	DepMap	Descartes	0.32	9.74
LAMA4	0.0012852	484	GTEx	DepMap	Descartes	3.10	92.84
STARD13	0.0012495	499	GTEx	DepMap	Descartes	1.10	46.46
ADAMTS5	0.0011606	533	GTEx	DepMap	Descartes	0.45	13.42
SOX5	0.0008972	711	GTEx	DepMap	Descartes	0.28	10.01
PAG1	0.0007750	817	GTEx	DepMap	Descartes	1.71	37.03
DST	0.0007397	852	GTEx	DepMap	Descartes	4.22	45.42
COL25A1	0.0006175	1013	GTEx	DepMap	Descartes	0.07	1.87
VIM	0.0004713	1268	GTEx	DepMap	Descartes	43.93	3612.93
HMGA2	0.0004061	1399	GTEx	DepMap	Descartes	0.12	3.27
COL5A2	0.0003646	1532	GTEx	DepMap	Descartes	2.91	91.63
ERBB4	0.0003596	1546	GTEx	DepMap	Descartes	0.03	0.94
PTN	0.0001437	2579	GTEx	DepMap	Descartes	0.43	49.23
TRPM3	0.0001363	2642	GTEx	DepMap	Descartes	0.09	1.88
IL1RAPL2	-0.0000943	5663	GTEx	DepMap	Descartes	0.00	0.20
NRXN3	-0.0001279	6367	GTEx	DepMap	Descartes	0.21	4.89
FIGN	-0.0001435	6679	GTEx	DepMap	Descartes	0.23	7.49
IL1RAPL1	-0.0001672	7186	GTEx	DepMap	Descartes	0.02	0.77
SLC35F1	-0.0001787	7407	GTEx	DepMap	Descartes	0.17	5.92
LRRTM4	-0.0002346	8391	GTEx	DepMap	Descartes	0.01	1.25
MDGA2	-0.0002502	8664	GTEx	DepMap	Descartes	0.00	0.12
MPZ	-0.0002926	9307	GTEx	DepMap	Descartes	0.12	10.56
VCAN	-0.0003269	9767	GTEx	DepMap	Descartes	7.64	130.59
PTPRZ1	-0.0004628	11012	GTEx	DepMap	Descartes	0.13	1.65
PMP22	-0.0004686	11053	GTEx	DepMap	Descartes	1.42	148.90

Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.44e-03
Mean rank of genes in gene set: 4902.29
Median rank of genes in gene set: 2528
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
MYLK	0.0098068	7	GTEx	DepMap	Descartes	6.17	154.64
HIPK2	0.0045512	69	GTEx	DepMap	Descartes	3.65	62.19
PDE3A	0.0043605	75	GTEx	DepMap	Descartes	1.34	44.22
TPM4	0.0042317	78	GTEx	DepMap	Descartes	9.64	414.86
VCL	0.0041118	84	GTEx	DepMap	Descartes	4.04	119.41
MYH9	0.0035678	116	GTEx	DepMap	Descartes	13.21	427.98
ANGPT1	0.0032814	132	GTEx	DepMap	Descartes	0.61	42.88
TRPC6	0.0029333	157	GTEx	DepMap	Descartes	0.19	8.99
ACTN1	0.0028632	162	GTEx	DepMap	Descartes	6.89	354.52
FLNA	0.0025813	187	GTEx	DepMap	Descartes	6.93	208.55
TLN1	0.0025630	189	GTEx	DepMap	Descartes	4.97	142.39
INPP4B	0.0021432	248	GTEx	DepMap	Descartes	0.73	25.57
ARHGAP6	0.0020996	261	GTEx	DepMap	Descartes	0.26	10.51
STOM	0.0019476	299	GTEx	DepMap	Descartes	5.51	392.94
LIMS1	0.0015094	413	GTEx	DepMap	Descartes	3.55	177.04
LTBP1	0.0014043	442	GTEx	DepMap	Descartes	1.57	60.08
ACTB	0.0010740	580	GTEx	DepMap	Descartes	26.95	2644.33
THBS1	0.0008802	726	GTEx	DepMap	Descartes	13.75	493.10
CD9	0.0008407	758	GTEx	DepMap	Descartes	1.80	205.33
ITGB3	0.0008271	767	GTEx	DepMap	Descartes	0.09	4.83
ZYX	0.0007092	894	GTEx	DepMap	Descartes	3.44	337.16
SLC24A3	0.0003997	1422	GTEx	DepMap	Descartes	0.10	5.50
TUBB1	0.0001508	2528	GTEx	DepMap	Descartes	0.01	0.57
ITGA2B	0.0001092	2826	GTEx	DepMap	Descartes	0.05	5.04
GP1BA	0.0000934	2978	GTEx	DepMap	Descartes	0.04	2.00
DOK6	-0.0000311	4511	GTEx	DepMap	Descartes	0.13	2.81
P2RX1	-0.0000327	4537	GTEx	DepMap	Descartes	0.02	1.84
RAB27B	-0.0001773	7380	GTEx	DepMap	Descartes	0.01	0.45
RAP1B	-0.0001864	7555	GTEx	DepMap	Descartes	1.14	19.00
STON2	-0.0002357	8410	GTEx	DepMap	Descartes	0.07	4.07

Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9676.71
Median rank of genes in gene set: 11592
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ARID5B	0.0033304	130	GTEx	DepMap	Descartes	8.95	308.50
ETS1	0.0005951	1053	GTEx	DepMap	Descartes	4.99	200.60
FOXP1	0.0004612	1278	GTEx	DepMap	Descartes	3.99	109.56
SP100	0.0003663	1523	GTEx	DepMap	Descartes	1.57	68.32
NCALD	0.0002336	2049	GTEx	DepMap	Descartes	0.33	25.51
ARHGAP15	0.0000917	2996	GTEx	DepMap	Descartes	0.41	33.76
MSN	0.0000141	3840	GTEx	DepMap	Descartes	2.84	157.34
RCSD1	-0.0000129	4235	GTEx	DepMap	Descartes	0.18	7.72
DOCK10	-0.0000632	5047	GTEx	DepMap	Descartes	0.49	17.60
ITPKB	-0.0000912	5606	GTEx	DepMap	Descartes	0.81	28.67
STK39	-0.0003207	9693	GTEx	DepMap	Descartes	0.19	15.46
PITPNC1	-0.0003366	9869	GTEx	DepMap	Descartes	1.09	36.43
BCL2	-0.0003785	10325	GTEx	DepMap	Descartes	0.45	12.97
CCND3	-0.0004543	10956	GTEx	DepMap	Descartes	0.31	26.55
MCTP2	-0.0004869	11166	GTEx	DepMap	Descartes	0.02	0.23
SAMD3	-0.0005152	11333	GTEx	DepMap	Descartes	0.02	1.13
B2M	-0.0005207	11365	GTEx	DepMap	Descartes	44.35	4154.85
SCML4	-0.0005448	11488	GTEx	DepMap	Descartes	0.02	1.20
SKAP1	-0.0005502	11521	GTEx	DepMap	Descartes	0.00	0.15
CD44	-0.0005543	11537	GTEx	DepMap	Descartes	5.08	234.94
PLEKHA2	-0.0005586	11556	GTEx	DepMap	Descartes	0.66	26.11
BACH2	-0.0005787	11628	GTEx	DepMap	Descartes	0.18	4.24
RAP1GAP2	-0.0005816	11637	GTEx	DepMap	Descartes	0.07	2.03
ANKRD44	-0.0006171	11733	GTEx	DepMap	Descartes	0.19	6.06
TOX	-0.0006846	11928	GTEx	DepMap	Descartes	0.01	0.10
MBNL1	-0.0007368	12059	GTEx	DepMap	Descartes	2.43	91.70
ARHGDIB	-0.0008006	12179	GTEx	DepMap	Descartes	2.63	487.99
LEF1	-0.0008456	12242	GTEx	DepMap	Descartes	0.19	9.02
PDE3B	-0.0009327	12334	GTEx	DepMap	Descartes	0.04	0.79
EVL	-0.0009431	12345	GTEx	DepMap	Descartes	0.81	47.18

Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.24e-03
Mean rank of genes in gene set: 3097.22
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	0.0020463	276	GTEx	DepMap	Descartes	2.65	160.77
NTRK2	0.0018890	310	GTEx	DepMap	Descartes	1.16	40.04
SMOC2	0.0016453	375	GTEx	DepMap	Descartes	1.79	148.15
EBF2	0.0011881	521	GTEx	DepMap	Descartes	0.52	26.95
OLFML1	0.0004252	1351	GTEx	DepMap	Descartes	0.44	34.90
F10	0.0002073	2166	GTEx	DepMap	Descartes	0.15	21.79
ANGPTL1	0.0001534	2508	GTEx	DepMap	Descartes	0.26	17.80
PDGFRA	-0.0002019	7831	GTEx	DepMap	Descartes	1.17	34.62
SFRP1	-0.0015958	12537	GTEx	DepMap	Descartes	0.52	21.02

B cells: Transitional B cells (curated markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.76e-02
Mean rank of genes in gene set: 230
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYO1C	0.0022429	230	GTEx	DepMap	Descartes	1.88	88.95

Macrophages: Hofbauer cells (curated markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.43e-02
Mean rank of genes in gene set: 770
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCIN	0.0008249	770	GTEx	DepMap	Descartes	0.12	3.2

Megakaryocyte precursor: Megakaryocyte precursor (model markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.32e-01
Mean rank of genes in gene set: 3418.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADRA2A	0.0008961	714	GTEx	DepMap	Descartes	0.34	24.80
SLC10A5	-0.0001158	6123	GTEx	DepMap	Descartes	0.01	0.68

pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.59e-01
Mean rank of genes in gene set: 3719
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCDC50	8.75e-05	3032	GTEx	DepMap	Descartes	1.02	25.51
IRF7	-2.47e-05	4406	GTEx	DepMap	Descartes	0.35	45.36

Plasma cells: Plasma cells (curated markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.98e-01
Mean rank of genes in gene set: 4100.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
XBP1	0.0006342	997	GTEx	DepMap	Descartes	2.90	305.19
MZB1	-0.0001681	7204	GTEx	DepMap	Descartes	0.03	NA

Megakaryocytes/platelets: Megakaryocytes/platelets (curated markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.02e-01
Mean rank of genes in gene set: 4134.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	0.0001092	2826	GTEx	DepMap	Descartes	0.05	5.04
CMTM5	-0.0000833	5443	GTEx	DepMap	Descartes	0.01	0.60

Epithelial cells: Epithelial cells (curated markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.07e-01
Mean rank of genes in gene set: 3320
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT17	5.91e-05	3320	GTEx	DepMap	Descartes	0.02	1.74

Double-negative thymocytes: Double-negative thymocytes (curated markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.10e-01
Mean rank of genes in gene set: 4206
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HES1	0.0005024	1205	GTEx	DepMap	Descartes	4.56	711.66
FXYD2	-0.0001682	7207	GTEx	DepMap	Descartes	0.02	0.88

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.12e-01
Mean rank of genes in gene set: 3373
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CKB	5.31e-05	3373	GTEx	DepMap	Descartes	1.19	194.99

T cells: NKT cells (model markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.30e-01
Mean rank of genes in gene set: 4729.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITM2C	0.0010621	587	GTEx	DepMap	Descartes	1.84	219.21
PRDM16	0.0005319	1156	GTEx	DepMap	Descartes	0.09	3.77
CD52	-0.0011126	12445	GTEx	DepMap	Descartes	0.03	7.71

T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.35e-01
Mean rank of genes in gene set: 4421.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
INPP5J	0.0005273	1163	GTEx	DepMap	Descartes	0.08	7.45
PANX2	-0.0001934	7680	GTEx	DepMap	Descartes	0.01	0.68

Plasma cells: Plasma cells (model markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.64e-01
Mean rank of genes in gene set: 5133.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
XBP1	0.0006342	997	GTEx	DepMap	Descartes	2.90	305.19
TGFBR3L	0.0000115	3871	GTEx	DepMap	Descartes	0.01	NA
MZB1	-0.0001681	7204	GTEx	DepMap	Descartes	0.03	NA
ST18	-0.0002387	8463	GTEx	DepMap	Descartes	0.01	0.48

Macrophages: Kupffer cells (curated markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.69e-01
Mean rank of genes in gene set: 4695.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAM1	0.0001338	2660	GTEx	DepMap	Descartes	1.82	100.01
CD5L	-0.0001457	6731	GTEx	DepMap	Descartes	0.07	7.23

B cells: Germinal center B cells (model markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.77e-01
Mean rank of genes in gene set: 4759
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AICDA	-1.61e-05	4297	GTEx	DepMap	Descartes	0.00	0.16
BMP3	-7.19e-05	5221	GTEx	DepMap	Descartes	0.01	0.48

Monocytes: Non-classical monocytes (model markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.80e-01
Mean rank of genes in gene set: 5220.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RHOC	0.0010198	613	GTEx	DepMap	Descartes	1.81	162.11
BAG3	0.0009765	649	GTEx	DepMap	Descartes	7.02	609.96
CUX2	-0.0002163	8100	GTEx	DepMap	Descartes	0.00	0.09
ABI3	-0.0005500	11520	GTEx	DepMap	Descartes	0.07	7.35

Granulocytes: Neutrophils (curated markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.11e-01
Mean rank of genes in gene set: 4489
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCN2	-3e-05	4489	GTEx	DepMap	Descartes	0	0

T cells: Trm cytotoxic T cells (curated markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.25e-01
Mean rank of genes in gene set: 5115.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA1	0.0051875	47	GTEx	DepMap	Descartes	5.40	111.58
ITGAE	-0.0003653	10184	GTEx	DepMap	Descartes	0.11	4.98

Granulocytes: Granulocytes (model markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.36e-01
Mean rank of genes in gene set: 5190
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAK	-0.0000141	4257	GTEx	DepMap	Descartes	0.05	2.38
SLC10A5	-0.0001158	6123	GTEx	DepMap	Descartes	0.01	0.68

T cells: Tem/Effector helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.39e-01
Mean rank of genes in gene set: 5409
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB1	0.0028444	164	GTEx	DepMap	Descartes	4.43	255.42
AQP3	-0.0000256	4425	GTEx	DepMap	Descartes	0.25	17.84
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98

Erythroid: Early erythroid (model markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.42e-01
Mean rank of genes in gene set: 5539.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FAM178B	0.0004181	1365	GTEx	DepMap	Descartes	0.01	1.76
PRSS57	-0.0000900	5586	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37
APOC1	-0.0002515	8688	GTEx	DepMap	Descartes	0.38	135.66

pDC: pDC (model markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.47e-01
Mean rank of genes in gene set: 5269.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TRIM71	0.0003219	1676	GTEx	DepMap	Descartes	0.01	0.08
OGDHL	-0.0002642	8863	GTEx	DepMap	Descartes	0.01	0.55

ETP: ETP (model markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.60e-01
Mean rank of genes in gene set: 5356.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-6.65e-05	5112	GTEx	DepMap	Descartes	0.00	0.34
PENK	-9.08e-05	5601	GTEx	DepMap	Descartes	0.04	9.67

DC: Migratory DCs (model markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.74e-01
Mean rank of genes in gene set: 5112
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-6.65e-05	5112	GTEx	DepMap	Descartes	0	0.34

ILC precursor: ILC precursor (model markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.76e-01
Mean rank of genes in gene set: 5611.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HUNK	-0.0000179	4317	GTEx	DepMap	Descartes	0.05	1.07
HPN	-0.0000555	4893	GTEx	DepMap	Descartes	0.01	2.05
PDZK1	-0.0001898	7625	GTEx	DepMap	Descartes	0.00	0.13

ILC: CD16+ NK cells (model markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.95e-01
Mean rank of genes in gene set: 5841.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADAMTS1	0.0070995	15	GTEx	DepMap	Descartes	10.30	542.44
IGFBP7	0.0054871	41	GTEx	DepMap	Descartes	90.37	14869.03
PRSS57	-0.0000900	5586	GTEx	DepMap	Descartes	0.00	0.00
FCER1G	-0.0005465	11501	GTEx	DepMap	Descartes	0.16	68.11
TYROBP	-0.0007384	12065	GTEx	DepMap	Descartes	0.18	63.65

ILC: NK cells (model markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.04e-01
Mean rank of genes in gene set: 5942.14
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLHL23	0.0020254	280	GTEx	DepMap	Descartes	0.50	31.44
IGFBP4	0.0018943	308	GTEx	DepMap	Descartes	10.85	1069.54
MALAT1	0.0009921	643	GTEx	DepMap	Descartes	118.15	3412.65
SPINK2	-0.0001127	6065	GTEx	DepMap	Descartes	0.00	0.00
CST3	-0.0003938	10480	GTEx	DepMap	Descartes	8.27	564.22
HMOX1	-0.0005451	11489	GTEx	DepMap	Descartes	2.07	231.01
STMN1	-0.0009256	12330	GTEx	DepMap	Descartes	1.32	96.68

Erythroid: Late erythroid (model markers)
late erythroid cells following early and middle erythroid cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.04e-01
Mean rank of genes in gene set: 5653.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC12A3	-0.0000493	4788	GTEx	DepMap	Descartes	0.00	0.00
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37

Early MK: Early MK (curated markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.09e-01
Mean rank of genes in gene set: 5443
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	-8.33e-05	5443	GTEx	DepMap	Descartes	0.01	0.6

pDC precursor: pDC precursor (model markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.16e-01
Mean rank of genes in gene set: 5510
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	-8.63e-05	5510	GTEx	DepMap	Descartes	0	0

DC: Transitional DC (curated markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.24e-01
Mean rank of genes in gene set: 5783
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AXL	0.0030192	151	GTEx	DepMap	Descartes	2.21	121.35
KLF4	-0.0005313	11415	GTEx	DepMap	Descartes	3.57	276.95

T cells: Memory CD4+ cytotoxic T cells (model markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.26e-01
Mean rank of genes in gene set: 5601
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	-9.08e-05	5601	GTEx	DepMap	Descartes	0.04	9.67

Cycling cells: Cycling DCs (model markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.02e-01
Mean rank of genes in gene set: 6295
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP12	-0.0001248	6295	GTEx	DepMap	Descartes	0.01	0.23

Epithelial cells: Epithelial cells (model markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.05e-01
Mean rank of genes in gene set: 6310
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDH3	-0.0000480	4760	GTEx	DepMap	Descartes	0.02	1.26
WFDC2	-0.0002032	7860	GTEx	DepMap	Descartes	0.02	5.14

B-cell lineage: Small pre-B cells (model markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.09e-01
Mean rank of genes in gene set: 6317
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AICDA	-0.0000161	4297	GTEx	DepMap	Descartes	0.00	0.16
TLDC2	-0.0001144	6092	GTEx	DepMap	Descartes	0.00	NA
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37
CD79B	-0.0002327	8360	GTEx	DepMap	Descartes	0.05	6.34

DC: DC1 (curated markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.17e-01
Mean rank of genes in gene set: 6385
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BATF3	0.0010851	575	GTEx	DepMap	Descartes	0.34	35.27
CADM1	-0.0008113	12195	GTEx	DepMap	Descartes	0.47	10.21

T cells: Type 17 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.18e-01
Mean rank of genes in gene set: 6393
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZBTB16	0.0016841	362	GTEx	DepMap	Descartes	0.87	26.15
IL7R	-0.0010732	12424	GTEx	DepMap	Descartes	0.31	11.11

B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.24e-01
Mean rank of genes in gene set: 6426
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
YBX3	0.0018238	323	GTEx	DepMap	Descartes	4.26	NA
CD74	-0.0015006	12529	GTEx	DepMap	Descartes	7.97	475.06

Cycling cells: Cycling T cells (model markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.27e-01
Mean rank of genes in gene set: 6519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37

ILC: ILC3 (model markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.27e-01
Mean rank of genes in gene set: 6519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37

Promyelocytes: Promyelocytes (model markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.27e-01
Mean rank of genes in gene set: 6519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37

HSC/MPP: Early lymphoid/T lymphoid (curated markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.78e-01
Mean rank of genes in gene set: 6777
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ETS1	0.0005951	1053	GTEx	DepMap	Descartes	4.99	200.60
GATA3	-0.0012853	12501	GTEx	DepMap	Descartes	0.20	11.73

ILC: ILC (curated markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.80e-01
Mean rank of genes in gene set: 6697.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLE1	0.0012947	477	GTEx	DepMap	Descartes	0.97	62.20
S100A13	-0.0002918	9298	GTEx	DepMap	Descartes	0.47	42.84
AREG	-0.0003779	10318	GTEx	DepMap	Descartes	0.07	20.43

B cells: Memory B cells (model markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.91e-01
Mean rank of genes in gene set: 6867
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HES1	0.0005024	1205	GTEx	DepMap	Descartes	4.56	711.66
CD74	-0.0015006	12529	GTEx	DepMap	Descartes	7.97	475.06

B-cell lineage: Large pre-B cells (model markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.99e-01
Mean rank of genes in gene set: 7186
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0001672	7186	GTEx	DepMap	Descartes	0.02	0.77

DC: DC1 (model markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.99e-01
Mean rank of genes in gene set: 7186
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0001672	7186	GTEx	DepMap	Descartes	0.02	0.77

Erythrocytes: Erythrocytes (model markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.99e-01
Mean rank of genes in gene set: 7186
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	-0.0001672	7186	GTEx	DepMap	Descartes	0.02	0.77

Double-negative thymocytes: Double-negative thymocytes (model markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.02e-01
Mean rank of genes in gene set: 6658.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDLIM1	0.0016952	358	GTEx	DepMap	Descartes	3.97	658.36
MFAP4	0.0013674	454	GTEx	DepMap	Descartes	6.79	803.98
MZB1	-0.0001681	7204	GTEx	DepMap	Descartes	0.03	NA
FXYD2	-0.0001682	7207	GTEx	DepMap	Descartes	0.02	0.88
CD7	-0.0009295	12332	GTEx	DepMap	Descartes	0.07	6.33
SELL	-0.0010072	12394	GTEx	DepMap	Descartes	0.17	8.88

DC: DC3 (model markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.18e-01
Mean rank of genes in gene set: 7042
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0000719	5221	GTEx	DepMap	Descartes	0.01	0.48
OGDHL	-0.0002642	8863	GTEx	DepMap	Descartes	0.01	0.55

ILC: ILC2 (model markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.34e-01
Mean rank of genes in gene set: 7517
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL17RB	-0.0001847	7517	GTEx	DepMap	Descartes	0.01	1.31

Granulocytes: Granulocytes (curated markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.39e-01
Mean rank of genes in gene set: 7020.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC45A3	0.0000473	3441	GTEx	DepMap	Descartes	0.08	4.31
CPA3	-0.0002594	8800	GTEx	DepMap	Descartes	0.01	1.46
KIT	-0.0002611	8821	GTEx	DepMap	Descartes	0.10	4.23

Macrophages: Hofbauer cells (model markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.51e-01
Mean rank of genes in gene set: 7680
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PANX2	-0.0001934	7680	GTEx	DepMap	Descartes	0.01	0.68

Early MK: Early MK (model markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.57e-01
Mean rank of genes in gene set: 7313
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37
CCDC175	-0.0002164	8107	GTEx	DepMap	Descartes	0.01	NA

Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.86e-01
Mean rank of genes in gene set: 7150.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
APOE	0.0005002	1211	GTEx	DepMap	Descartes	7.85	1410.49
CD5L	-0.0001457	6731	GTEx	DepMap	Descartes	0.07	7.23
APOC1	-0.0002515	8688	GTEx	DepMap	Descartes	0.38	135.66
FTH1	-0.0006968	11971	GTEx	DepMap	Descartes	21.33	3884.35

HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.87e-01
Mean rank of genes in gene set: 7525.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	0.0001092	2826	GTEx	DepMap	Descartes	0.05	5.04
GATA2	-0.0008292	12225	GTEx	DepMap	Descartes	0.24	14.72

HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.93e-01
Mean rank of genes in gene set: 8100
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0002163	8100	GTEx	DepMap	Descartes	0	0.09

ILC: CD16- NK cells (curated markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.00e-01
Mean rank of genes in gene set: 8176
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD160	-0.0002204	8176	GTEx	DepMap	Descartes	0.01	1

ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.01e-01
Mean rank of genes in gene set: 7378.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPN	-0.0000555	4893	GTEx	DepMap	Descartes	0.01	2.05
SCN1B	-0.0001406	6620	GTEx	DepMap	Descartes	0.15	5.68
LST1	-0.0004118	10623	GTEx	DepMap	Descartes	0.04	3.76

HSC/MPP: CMP (model markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.06e-01
Mean rank of genes in gene set: 7659.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37
CPA3	-0.0002594	8800	GTEx	DepMap	Descartes	0.01	1.46

Monocytes: Classical monocytes (curated markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.09e-01
Mean rank of genes in gene set: 8269
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD14	-0.0002264	8269	GTEx	DepMap	Descartes	0.29	40.08

HSC/MPP: Early lymphoid/T lymphoid (model markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.27e-01
Mean rank of genes in gene set: 8463
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.0002387	8463	GTEx	DepMap	Descartes	0.01	0.48

T cells: Follicular helper T cells (model markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.34e-01
Mean rank of genes in gene set: 7407
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CH25H	0.0000729	3175	GTEx	DepMap	Descartes	0.08	17.57
SOCS3	-0.0001227	6253	GTEx	DepMap	Descartes	4.81	490.98
HOXB5	-0.0002439	8562	GTEx	DepMap	Descartes	0.04	3.73
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98

Mast cells: Mast cells (model markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.57e-01
Mean rank of genes in gene set: 8800
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	-0.0002594	8800	GTEx	DepMap	Descartes	0.01	1.46

DC precursor: DC precursor (model markers)
dendritic cell precursors that differentiate into dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.63e-01
Mean rank of genes in gene set: 8863
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	-0.0002642	8863	GTEx	DepMap	Descartes	0.01	0.55

ILC: Transitional NK (model markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.67e-01
Mean rank of genes in gene set: 7592.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	0.0005319	1156	GTEx	DepMap	Descartes	0.09	3.77
AGRP	-0.0000863	5510	GTEx	DepMap	Descartes	0.00	0.00
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
TYROBP	-0.0007384	12065	GTEx	DepMap	Descartes	0.18	63.65

HSC/MPP: HSC/MPP (model markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.69e-01
Mean rank of genes in gene set: 8163
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPINK2	-0.0001127	6065	GTEx	DepMap	Descartes	0	0
GRIN1	-0.0003728	10261	GTEx	DepMap	Descartes	0	0

Monocyte precursor: Monocyte precursor (model markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.83e-01
Mean rank of genes in gene set: 8281.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0002163	8100	GTEx	DepMap	Descartes	0.00	0.09
ST18	-0.0002387	8463	GTEx	DepMap	Descartes	0.01	0.48

Mast cells: Mast cells (curated markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.91e-01
Mean rank of genes in gene set: 8346.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPSB2	-0.0002048	7893	GTEx	DepMap	Descartes	0.04	5.72
CPA3	-0.0002594	8800	GTEx	DepMap	Descartes	0.01	1.46

T cells: Type 1 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.93e-01
Mean rank of genes in gene set: 7599.2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CEBPB	0.0019086	306	GTEx	DepMap	Descartes	8.23	1104.81
PRDM16	0.0005319	1156	GTEx	DepMap	Descartes	0.09	3.77
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69
ANXA1	-0.0013273	12509	GTEx	DepMap	Descartes	5.48	478.98

Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.97e-01
Mean rank of genes in gene set: 8014.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	0.0047122	60	GTEx	DepMap	Descartes	8.55	716.85
CLDN5	-0.0006848	11931	GTEx	DepMap	Descartes	0.37	26.50
PLVAP	-0.0007343	12053	GTEx	DepMap	Descartes	2.69	175.78

B cells: B cells (model markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.04e-01
Mean rank of genes in gene set: 8065.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0009921	643	GTEx	DepMap	Descartes	118.15	3412.65
CD79A	-0.0004643	11025	GTEx	DepMap	Descartes	0.05	6.12
CD74	-0.0015006	12529	GTEx	DepMap	Descartes	7.97	475.06

B cells: Germinal center B cells (curated markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.10e-01
Mean rank of genes in gene set: 8520
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD40	-0.0002128	8031	GTEx	DepMap	Descartes	0.31	34.40
POU2AF1	-0.0002734	9009	GTEx	DepMap	Descartes	0.01	0.36

ILC: ILC3 (curated markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.17e-01
Mean rank of genes in gene set: 8165.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RORC	-0.0001544	6906	GTEx	DepMap	Descartes	0.00	0.00
IL4I1	-0.0002575	8769	GTEx	DepMap	Descartes	0.03	2.62
KIT	-0.0002611	8821	GTEx	DepMap	Descartes	0.10	4.23

T cells: Regulatory T cells (curated markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.23e-01
Mean rank of genes in gene set: 9626
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-0.0003146	9626	GTEx	DepMap	Descartes	0.02	1.24

Monocyte precursor: Monocyte precursor (curated markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.32e-01
Mean rank of genes in gene set: 9767
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	-0.0003269	9767	GTEx	DepMap	Descartes	7.64	130.59

pDC: pDC (curated markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.35e-01
Mean rank of genes in gene set: 9797
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLD4	-0.0003297	9797	GTEx	DepMap	Descartes	0.02	1.28

Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.37e-01
Mean rank of genes in gene set: 8331.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0007654	825	GTEx	DepMap	Descartes	38.94	429.15
TYROBP	-0.0007384	12065	GTEx	DepMap	Descartes	0.18	63.65
SAT1	-0.0007608	12105	GTEx	DepMap	Descartes	3.96	800.61

T cells: Treg(diff) (model markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.40e-01
Mean rank of genes in gene set: 8074.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A4	0.0003696	1511	GTEx	DepMap	Descartes	1.32	447.47
TSC22D3	-0.0001003	5799	GTEx	DepMap	Descartes	2.58	255.57
RGS1	-0.0011432	12462	GTEx	DepMap	Descartes	0.13	6.16
PTPRC	-0.0014620	12526	GTEx	DepMap	Descartes	0.20	6.67

Cycling cells: Cycling B cells (model markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.46e-01
Mean rank of genes in gene set: 8405.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37
RGS13	-0.0002370	8437	GTEx	DepMap	Descartes	0.01	0.09
GRIN1	-0.0003728	10261	GTEx	DepMap	Descartes	0.00	0.00

Megakaryocyte precursor: Megakaryocyte precursor (curated markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.48e-01
Mean rank of genes in gene set: 8905.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRSS57	-0.0000900	5586	GTEx	DepMap	Descartes	0.00	0.00
GATA2	-0.0008292	12225	GTEx	DepMap	Descartes	0.24	14.72

B-cell lineage: Pre-pro-B cells (curated markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.57e-01
Mean rank of genes in gene set: 9004.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZCCHC7	-0.0000900	5585	GTEx	DepMap	Descartes	0.16	12.33
IL7R	-0.0010732	12424	GTEx	DepMap	Descartes	0.31	11.11

T cells: Type 17 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.62e-01
Mean rank of genes in gene set: 8552.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A4	0.0003696	1511	GTEx	DepMap	Descartes	1.32	447.47
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
ANXA1	-0.0013273	12509	GTEx	DepMap	Descartes	5.48	478.98

T cells: Treg(diff) (curated markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.65e-01
Mean rank of genes in gene set: 8579.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF4	0.0002078	2162	GTEx	DepMap	Descartes	0.26	11.77
CD27	-0.0005499	11519	GTEx	DepMap	Descartes	0.00	0.34
CCR7	-0.0007364	12058	GTEx	DepMap	Descartes	0.20	12.69

DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.67e-01
Mean rank of genes in gene set: 8601
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	-0.0000863	5510	GTEx	DepMap	Descartes	0.00	0.00
MMP9	-0.0003310	9813	GTEx	DepMap	Descartes	0.07	4.63
CST3	-0.0003938	10480	GTEx	DepMap	Descartes	8.27	564.22

B-cell lineage: Small pre-B cells (curated markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.79e-01
Mean rank of genes in gene set: 10511
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0003977	10511	GTEx	DepMap	Descartes	0.05	1.41

B-cell lineage: Pro-B cells (curated markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.79e-01
Mean rank of genes in gene set: 10511
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0003977	10511	GTEx	DepMap	Descartes	0.05	1.41

ETP: ETP (curated markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.81e-01
Mean rank of genes in gene set: 9299
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPINK2	-0.0001127	6065	GTEx	DepMap	Descartes	0.00	0.00
CD34	-0.0015257	12533	GTEx	DepMap	Descartes	0.63	10.44

HSC/MPP: HSC/MPP (curated markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.92e-01
Mean rank of genes in gene set: 8862.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPINK2	-0.0001127	6065	GTEx	DepMap	Descartes	0.00	0.00
CRHBP	-0.0002105	7990	GTEx	DepMap	Descartes	0.00	0.00
CD34	-0.0015257	12533	GTEx	DepMap	Descartes	0.63	10.44

Macrophages: Macrophages (curated markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.16e-01
Mean rank of genes in gene set: 11265
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD68	-0.0005037	11265	GTEx	DepMap	Descartes	0.21	26.38

T cells: MAIT cells (curated markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.16e-01
Mean rank of genes in gene set: 9806
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC4A10	-0.0002096	7974	GTEx	DepMap	Descartes	0.00	0.28
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98

T cells: Tem/Effector helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.17e-01
Mean rank of genes in gene set: 8325.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A4	0.0003696	1511	GTEx	DepMap	Descartes	1.32	447.47
AQP3	-0.0000256	4425	GTEx	DepMap	Descartes	0.25	17.84
DONSON	-0.0001878	7586	GTEx	DepMap	Descartes	0.19	19.01
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
LTB	-0.0008885	12282	GTEx	DepMap	Descartes	0.09	6.75
ANXA1	-0.0013273	12509	GTEx	DepMap	Descartes	5.48	478.98

B cells: Follicular B cells (model markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.22e-01
Mean rank of genes in gene set: 9907
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VPREB3	-0.0001922	7660	GTEx	DepMap	Descartes	0.02	6.62
CD83	-0.0007877	12154	GTEx	DepMap	Descartes	0.68	54.91

B cells: Memory B cells (curated markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.26e-01
Mean rank of genes in gene set: 11519
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD27	-0.0005499	11519	GTEx	DepMap	Descartes	0	0.34

B cells: Transitional B cells (model markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.27e-01
Mean rank of genes in gene set: 11549
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GNG3	-0.0005562	11549	GTEx	DepMap	Descartes	0.02	6.73

B cells: Follicular B cells (curated markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.32e-01
Mean rank of genes in gene set: 10089
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD22	-0.0003497	10022	GTEx	DepMap	Descartes	0.03	1.02
CXCR5	-0.0003629	10156	GTEx	DepMap	Descartes	0.04	2.20

Macrophages: Kupffer cells (model markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.32e-01
Mean rank of genes in gene set: 8977
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	-0.0000908	5601	GTEx	DepMap	Descartes	0.04	9.67
CD5L	-0.0001457	6731	GTEx	DepMap	Descartes	0.07	7.23
EGR2	-0.0005926	11676	GTEx	DepMap	Descartes	0.86	64.79
ARRDC3	-0.0006748	11900	GTEx	DepMap	Descartes	0.85	49.44

Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.34e-01
Mean rank of genes in gene set: 10124.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KL	-0.0003472	9988	GTEx	DepMap	Descartes	0.03	0.93
GRIN1	-0.0003728	10261	GTEx	DepMap	Descartes	0.00	0.00

B cells: B cells (curated markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.36e-01
Mean rank of genes in gene set: 10163.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0002923	9302	GTEx	DepMap	Descartes	0.02	0.42
CD79A	-0.0004643	11025	GTEx	DepMap	Descartes	0.05	6.12

T cells: Follicular helper T cells (curated markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.42e-01
Mean rank of genes in gene set: 10303
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-0.0003629	10156	GTEx	DepMap	Descartes	0.04	2.20
PDCD1	-0.0003914	10450	GTEx	DepMap	Descartes	0.00	0.17

MNP: MNP (curated markers)
mononuclear phagocytes including dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.44e-01
Mean rank of genes in gene set: 12027
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FGL2	-0.0007205	12027	GTEx	DepMap	Descartes	0.43	18.97

T cells: NKT cells (curated markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.49e-01
Mean rank of genes in gene set: 12197
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (curated markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.50e-01
Mean rank of genes in gene set: 12225
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GATA2	-0.0008292	12225	GTEx	DepMap	Descartes	0.24	14.72

ILC: ILC1 (curated markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.51e-01
Mean rank of genes in gene set: 12277
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF3	-0.0008832	12277	GTEx	DepMap	Descartes	0.04	1.03

Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 10584
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDX2	-0.0003542	10074	GTEx	DepMap	Descartes	0.69	82.95
KCNH2	-0.0004741	11094	GTEx	DepMap	Descartes	0.02	0.94

ILC: Transitional NK (curated markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 12387
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69

T cells: gamma-delta T cells (curated markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.54e-01
Mean rank of genes in gene set: 12387
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69

T cells: Tem/Temra cytotoxic T cells (model markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.55e-01
Mean rank of genes in gene set: 12424
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0010732	12424	GTEx	DepMap	Descartes	0.31	11.11

T cells: CD8a/b(entry) (curated markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.56e-01
Mean rank of genes in gene set: 12448
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SATB1	-0.0011191	12448	GTEx	DepMap	Descartes	0.26	5.74

DC: DC (model markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.56e-01
Mean rank of genes in gene set: 12462
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0011432	12462	GTEx	DepMap	Descartes	0.13	6.16

Macrophages: Kidney-resident macrophages (curated markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 12529
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	-0.0015006	12529	GTEx	DepMap	Descartes	7.97	475.06

B-cell lineage: Large pre-B cells (curated markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.59e-01
Mean rank of genes in gene set: 10726.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0003977	10511	GTEx	DepMap	Descartes	0.05	1.41
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29

T cells: gamma-delta T cells (model markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.61e-01
Mean rank of genes in gene set: 9950
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.TPM
KLRC2	-0.0002893	9262	GTEx	DepMap	Descartes	0.51
GRIN1	-0.0003728	10261	GTEx	DepMap	Descartes	0.00
KCNK10	-0.0003788	10327	GTEx	DepMap	Descartes	0.00

DC: Migratory DCs (curated markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.62e-01
Mean rank of genes in gene set: 10808.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EBI3	-0.0003099	9559	GTEx	DepMap	Descartes	0.01	1.05
CCR7	-0.0007364	12058	GTEx	DepMap	Descartes	0.20	12.69

T cells: Tem/Effector helper T cells PD1+ (curated markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.66e-01
Mean rank of genes in gene set: 10951
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0003914	10450	GTEx	DepMap	Descartes	0.00	0.17
CD4	-0.0005388	11452	GTEx	DepMap	Descartes	0.29	20.47

T cells: Memory CD4+ cytotoxic T cells (curated markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.70e-01
Mean rank of genes in gene set: 11106
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL10	-0.0004277	10760	GTEx	DepMap	Descartes	0.03	3.84
CD4	-0.0005388	11452	GTEx	DepMap	Descartes	0.29	20.47

T cells: CD8a/a (curated markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 11214
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0003914	10450	GTEx	DepMap	Descartes	0.00	0.17
GNG4	-0.0006976	11978	GTEx	DepMap	Descartes	0.06	2.18

Monocytes: Classical monocytes (model markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 10319.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	-0.0001358	6519	GTEx	DepMap	Descartes	0.01	0.37
CST7	-0.0008025	12182	GTEx	DepMap	Descartes	0.04	7.62
EEF1A1	-0.0008620	12257	GTEx	DepMap	Descartes	16.84	752.18

Cycling cells: Cycling DCs (curated markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 11403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 11403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 11403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Cycling cells: Cycling NK cells (curated markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 11403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Cycling cells: Cycling T cells (curated markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.77e-01
Mean rank of genes in gene set: 11403
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

T cells: Type 1 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.78e-01
Mean rank of genes in gene set: 11452
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TBX21	-0.0003982	10517	GTEx	DepMap	Descartes	0.00	0.00
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69

T cells: MAIT cells (model markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.78e-01
Mean rank of genes in gene set: 9937.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0000719	5221	GTEx	DepMap	Descartes	0.01	0.48
KLRG1	-0.0003931	10467	GTEx	DepMap	Descartes	0.00	0.00
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
IL7R	-0.0010732	12424	GTEx	DepMap	Descartes	0.31	11.11

ILC: ILC2 (curated markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 10521.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPGDS	-0.0002458	8596	GTEx	DepMap	Descartes	0.0	0.00
KLRG1	-0.0003931	10467	GTEx	DepMap	Descartes	0.0	0.00
GATA3	-0.0012853	12501	GTEx	DepMap	Descartes	0.2	11.73

T cells: Tcm/Naive helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.82e-01
Mean rank of genes in gene set: 10068.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTSL	-0.0000738	5258	GTEx	DepMap	Descartes	3.26	NA
FCGRT	-0.0003657	10190	GTEx	DepMap	Descartes	1.34	105.93
LTB	-0.0008885	12282	GTEx	DepMap	Descartes	0.09	6.75
TMSB10	-0.0017529	12544	GTEx	DepMap	Descartes	10.73	4729.53

Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.83e-01
Mean rank of genes in gene set: 9702.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ACTB	0.0010740	580	GTEx	DepMap	Descartes	26.95	2644.33
S100A6	-0.0005429	11479	GTEx	DepMap	Descartes	4.26	1460.53
FTH1	-0.0006968	11971	GTEx	DepMap	Descartes	21.33	3884.35
TYROBP	-0.0007384	12065	GTEx	DepMap	Descartes	0.18	63.65
SRGN	-0.0010579	12417	GTEx	DepMap	Descartes	8.08	1325.19

Cycling cells: Cycling B cells (curated markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.83e-01
Mean rank of genes in gene set: 10702.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0002923	9302	GTEx	DepMap	Descartes	0.02	0.42
MKI67	-0.0004527	10942	GTEx	DepMap	Descartes	0.03	0.29
TOP2A	-0.0006611	11864	GTEx	DepMap	Descartes	0.06	2.23

Mono-mac: Mono-mac (curated markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 11777
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HMOX1	-0.0005451	11489	GTEx	DepMap	Descartes	2.07	231.01
TYROBP	-0.0007384	12065	GTEx	DepMap	Descartes	0.18	63.65

T cells: Tcm/Naive cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 11781
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
B2M	-0.0005207	11365	GTEx	DepMap	Descartes	44.35	4154.85
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93

Double-positive thymocytes: Double-positive thymocytes (curated markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.85e-01
Mean rank of genes in gene set: 11827.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SMPD3	-0.0005398	11458	GTEx	DepMap	Descartes	0.02	0.44
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93

Erythroid: Early erythroid (curated markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.85e-01
Mean rank of genes in gene set: 10830
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
APOC1	-0.0002515	8688	GTEx	DepMap	Descartes	0.38	135.66
TESPA1	-0.0005643	11577	GTEx	DepMap	Descartes	0.04	NA
GATA2	-0.0008292	12225	GTEx	DepMap	Descartes	0.24	14.72

Mono-mac: Mono-mac (model markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-01
Mean rank of genes in gene set: 10274.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A2	-0.0000806	5385	GTEx	DepMap	Descartes	0.02	3.73
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
FTH1	-0.0006968	11971	GTEx	DepMap	Descartes	21.33	3884.35
SAT1	-0.0007608	12105	GTEx	DepMap	Descartes	3.96	800.61

HSC/MPP: ELP (curated markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-01
Mean rank of genes in gene set: 11936.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RUNX2	-0.0005680	11591	GTEx	DepMap	Descartes	0.09	2.82
LTB	-0.0008885	12282	GTEx	DepMap	Descartes	0.09	6.75

T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.88e-01
Mean rank of genes in gene set: 9943
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0009921	643	GTEx	DepMap	Descartes	118.15	3412.65
CD44	-0.0005543	11537	GTEx	DepMap	Descartes	5.08	234.94
SATB1	-0.0011191	12448	GTEx	DepMap	Descartes	0.26	5.74
ITM2A	-0.0017185	12543	GTEx	DepMap	Descartes	0.37	36.83
TMSB10	-0.0017529	12544	GTEx	DepMap	Descartes	10.73	4729.53

ILC: CD16- NK cells (model markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 9421
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GSTP1	0.0002522	1954	GTEx	DepMap	Descartes	1.69	221.66
CXCL3	-0.0001439	6690	GTEx	DepMap	Descartes	6.70	928.73
CLIC3	-0.0003448	9951	GTEx	DepMap	Descartes	0.01	1.97
FCER1G	-0.0005465	11501	GTEx	DepMap	Descartes	0.16	68.11
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
TYROBP	-0.0007384	12065	GTEx	DepMap	Descartes	0.18	63.65
LDB2	-0.0007856	12148	GTEx	DepMap	Descartes	0.63	41.20

T cells: Tem/Trm cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 12292
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69

Double-positive thymocytes: Double-positive thymocytes (model markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 9805.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RAG2	-0.0000986	5759	GTEx	DepMap	Descartes	0.00	0.00
ARPP21	-0.0003010	9430	GTEx	DepMap	Descartes	0.00	0.12
ELOVL4	-0.0003215	9706	GTEx	DepMap	Descartes	0.08	5.95
SH3TC1	-0.0003510	10036	GTEx	DepMap	Descartes	0.02	0.68
SMPD3	-0.0005398	11458	GTEx	DepMap	Descartes	0.02	0.44
CD52	-0.0011126	12445	GTEx	DepMap	Descartes	0.03	7.71

T cells: T(agonist) (curated markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 11869
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MIR155HG	-0.0005471	11504	GTEx	DepMap	Descartes	0.09	8.35
SMS	-0.0006127	11724	GTEx	DepMap	Descartes	0.36	43.95
BIRC3	-0.0009902	12379	GTEx	DepMap	Descartes	2.00	55.43

ILC: ILC (model markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 11160.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRIN1	-0.0003728	10261	GTEx	DepMap	Descartes	0.00	0.00
AREG	-0.0003779	10318	GTEx	DepMap	Descartes	0.07	20.43
KLRB1	-0.0005818	11638	GTEx	DepMap	Descartes	0.03	1.98
IL7R	-0.0010732	12424	GTEx	DepMap	Descartes	0.31	11.11

T cells: Tcm/Naive helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.97e-01
Mean rank of genes in gene set: 11968
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD4	-0.0005388	11452	GTEx	DepMap	Descartes	0.29	20.47
CCR7	-0.0007364	12058	GTEx	DepMap	Descartes	0.20	12.69
SELL	-0.0010072	12394	GTEx	DepMap	Descartes	0.17	8.88

T cells: Tcm/Naive cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12216.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCR7	-0.0007364	12058	GTEx	DepMap	Descartes	0.20	12.69
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93
SELL	-0.0010072	12394	GTEx	DepMap	Descartes	0.17	8.88

Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12224.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	-0.0006756	11903	GTEx	DepMap	Descartes	36.53	1254.37
COL1A1	-0.0008282	12222	GTEx	DepMap	Descartes	77.29	2593.54
DCN	-0.0023171	12549	GTEx	DepMap	Descartes	10.13	309.47

T cells: Tem/Trm cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12255.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CST7	-0.0008025	12182	GTEx	DepMap	Descartes	0.04	7.62
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69

T cells: Trm cytotoxic T cells (model markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12336
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93
CCL5	-0.0009979	12387	GTEx	DepMap	Descartes	0.11	12.69
IL7R	-0.0010732	12424	GTEx	DepMap	Descartes	0.31	11.11

T cells: Regulatory T cells (model markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 11564
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RTKN2	-0.0003460	9970	GTEx	DepMap	Descartes	0.07	2.88
TIGIT	-0.0005291	11407	GTEx	DepMap	Descartes	0.02	0.18
SRGN	-0.0010579	12417	GTEx	DepMap	Descartes	8.08	1325.19
RGS1	-0.0011432	12462	GTEx	DepMap	Descartes	0.13	6.16

T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 10471
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0009921	643	GTEx	DepMap	Descartes	118.15	3412.65
CD27	-0.0005499	11519	GTEx	DepMap	Descartes	0.00	0.34
CTSW	-0.0006672	11882	GTEx	DepMap	Descartes	0.01	1.49
CD8A	-0.0008132	12197	GTEx	DepMap	Descartes	0.03	0.93
LEF1	-0.0008456	12242	GTEx	DepMap	Descartes	0.19	9.02
NUCB2	-0.0009473	12348	GTEx	DepMap	Descartes	0.42	23.52
PRKCH	-0.0011496	12466	GTEx	DepMap	Descartes	0.23	8.39

Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12363.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RAMP3	-0.0007671	12117	GTEx	DepMap	Descartes	0.25	29.27
MMRN2	-0.0008624	12258	GTEx	DepMap	Descartes	0.41	13.04
JAM2	-0.0015089	12530	GTEx	DepMap	Descartes	0.34	11.86
VWF	-0.0020026	12548	GTEx	DepMap	Descartes	1.59	27.09

T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12186.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
B2M	-0.0005207	11365	GTEx	DepMap	Descartes	44.35	4154.85
SMS	-0.0006127	11724	GTEx	DepMap	Descartes	0.36	43.95
COTL1	-0.0008419	12239	GTEx	DepMap	Descartes	0.92	36.72
BIRC3	-0.0009902	12379	GTEx	DepMap	Descartes	2.00	55.43
PTPRC	-0.0014620	12526	GTEx	DepMap	Descartes	0.20	6.67
CD74	-0.0015006	12529	GTEx	DepMap	Descartes	7.97	475.06
ITM2A	-0.0017185	12543	GTEx	DepMap	Descartes	0.37	36.83

B cells: Naive B cells (curated markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
DC: DC (curated markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
DC: DC2 (curated markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
DC: DC3 (curated markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
DC precursor: DC precursor (curated markers)
dendritic cell precursors that differentiate into dendritic cells:
Erythrocytes: Erythrocytes (curated markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Erythroid: Late erythroid (curated markers)
late erythroid cells following early and middle erythroid cells:
HSC/MPP: CMP (curated markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
HSC/MPP: GMP (curated markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: Neutrophil-myeloid progenitor (curated markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
ILC: CD16+ NK cells (curated markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
ILC: NK cells (curated markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Monocytes: Non-classical monocytes (curated markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Monocytes: Monocytes (curated markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Myelocytes: Myelocytes (curated markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Promyelocytes: Promyelocytes (curated markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
T cells: Tem/Temra cytotoxic T cells (curated markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
B-cell lineage: Pre-pro-B cells (model markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
B-cell lineage: Pro-B cells (model markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Cycling cells: Cycling gamma-delta T cells (model markers)
proliferating gamma-delta (γδ) T lymphocytes:
Cycling cells: Cycling monocytes (model markers)
proliferating monocytes:
DC: Transitional DC (model markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Erythroid: Mid erythroid (model markers)
middle erythroid cells in fetal liver:
Granulocytes: Neutrophils (model markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
HSC/MPP: ELP (model markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
HSC/MPP: GMP (model markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: MEMP (model markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
ILC: ILC1 (model markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Macrophages: Kidney-resident macrophages (model markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Megakaryocytes/platelets: Megakaryocytes/platelets (model markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
MNP: MNP (model markers)
mononuclear phagocytes including dendritic cells: