Program: 13. Neuroblastoma #5.

Program: 13. Neuroblastoma #5.

Program description and justification of annotation: 13.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 NRG3 0.0133432 neuregulin 3 GTEx DepMap Descartes 6.38 2286.58
2 XIST 0.0132056 X inactive specific transcript GTEx DepMap Descartes 5.11 391.12
3 ADCY2 0.0130977 adenylate cyclase 2 GTEx DepMap Descartes 1.29 191.90
4 RTN1 0.0112144 reticulon 1 GTEx DepMap Descartes 8.99 3944.17
5 NEGR1 0.0111018 neuronal growth regulator 1 GTEx DepMap Descartes 6.53 720.77
6 RALYL 0.0104420 RALY RNA binding protein like GTEx DepMap Descartes 0.99 586.23
7 TSPAN8 0.0098982 tetraspanin 8 GTEx DepMap Descartes 0.67 665.38
8 DGKB 0.0098175 diacylglycerol kinase beta GTEx DepMap Descartes 9.37 1915.44
9 INPP4B 0.0095731 inositol polyphosphate-4-phosphatase type II B GTEx DepMap Descartes 2.73 433.56
10 SLC44A5 0.0094667 solute carrier family 44 member 5 GTEx DepMap Descartes 3.28 1089.30
11 PLXNA4 0.0093830 plexin A4 GTEx DepMap Descartes 2.16 225.01
12 HDAC9 0.0090456 histone deacetylase 9 GTEx DepMap Descartes 4.65 698.15
13 PDE11A 0.0089255 phosphodiesterase 11A GTEx DepMap Descartes 0.85 136.16
14 EPHA5 0.0084515 EPH receptor A5 GTEx DepMap Descartes 3.25 567.75
15 PRR16 0.0083915 proline rich 16 GTEx DepMap Descartes 2.16 1685.66
16 CNTNAP2 0.0083702 contactin associated protein 2 GTEx DepMap Descartes 25.57 3595.71
17 RORB 0.0082151 RAR related orphan receptor B GTEx DepMap Descartes 0.95 142.85
18 FREM1 0.0081201 FRAS1 related extracellular matrix 1 GTEx DepMap Descartes 1.10 164.38
19 DLC1 0.0078337 DLC1 Rho GTPase activating protein GTEx DepMap Descartes 12.04 2236.76
20 PRUNE2 0.0076302 prune homolog 2 with BCH domain GTEx DepMap Descartes 2.22 251.03
21 ITGA8 0.0075168 integrin subunit alpha 8 GTEx DepMap Descartes 1.71 365.79
22 STMN2 0.0071857 stathmin 2 GTEx DepMap Descartes 8.08 6150.03
23 EGFLAM 0.0070545 EGF like, fibronectin type III and laminin G domains GTEx DepMap Descartes 0.84 251.21
24 NRCAM 0.0068390 neuronal cell adhesion molecule GTEx DepMap Descartes 2.97 608.56
25 UNC5D 0.0066883 unc-5 netrin receptor D GTEx DepMap Descartes 2.37 326.88
26 HHIP 0.0066703 hedgehog interacting protein GTEx DepMap Descartes 0.80 109.48
27 RBFOX1 0.0064753 RNA binding fox-1 homolog 1 GTEx DepMap Descartes 10.18 2776.81
28 PPP2R2B 0.0064107 protein phosphatase 2 regulatory subunit Bbeta GTEx DepMap Descartes 2.42 303.16
29 DMD 0.0063290 dystrophin GTEx DepMap Descartes 2.66 264.58
30 TMC2 0.0062652 transmembrane channel like 2 GTEx DepMap Descartes 0.76 308.52
31 ANXA2 0.0062281 annexin A2 GTEx DepMap Descartes 1.07 442.76
32 ARRDC5 0.0062090 arrestin domain containing 5 GTEx DepMap Descartes 0.23 206.52
33 PARP4 0.0061295 poly(ADP-ribose) polymerase family member 4 GTEx DepMap Descartes 0.60 170.25
34 PCP4 0.0060681 Purkinje cell protein 4 GTEx DepMap Descartes 0.44 NA
35 KCNH5 0.0060545 potassium voltage-gated channel subfamily H member 5 GTEx DepMap Descartes 1.11 156.37
36 CHRM2 0.0060394 cholinergic receptor muscarinic 2 GTEx DepMap Descartes 2.77 632.88
37 KCNH7 0.0058768 potassium voltage-gated channel subfamily H member 7 GTEx DepMap Descartes 2.61 809.58
38 APBA1 0.0057738 amyloid beta precursor protein binding family A member 1 GTEx DepMap Descartes 1.38 289.12
39 LGR5 0.0057378 leucine rich repeat containing G protein-coupled receptor 5 GTEx DepMap Descartes 0.62 187.94
40 SLIT3 0.0057108 slit guidance ligand 3 GTEx DepMap Descartes 4.06 571.08
41 BMPER 0.0054656 BMP binding endothelial regulator GTEx DepMap Descartes 0.48 125.87
42 CD9 0.0053778 CD9 molecule GTEx DepMap Descartes 0.80 619.05
43 PCSK1N 0.0053008 proprotein convertase subtilisin/kexin type 1 inhibitor GTEx DepMap Descartes 3.29 4528.42
44 NDST3 0.0052833 N-deacetylase and N-sulfotransferase 3 GTEx DepMap Descartes 0.78 192.28
45 NPY 0.0052656 neuropeptide Y GTEx DepMap Descartes 11.40 22947.15
46 PMP22 0.0052437 peripheral myelin protein 22 GTEx DepMap Descartes 1.34 1051.51
47 L3MBTL4 0.0051117 L3MBTL histone methyl-lysine binding protein 4 GTEx DepMap Descartes 0.98 306.26
48 SLC8A1 0.0051105 solute carrier family 8 member A1 GTEx DepMap Descartes 6.57 412.74
49 DUOX1 0.0050971 dual oxidase 1 GTEx DepMap Descartes 1.67 418.79
50 UCHL1 0.0048998 ubiquitin C-terminal hydrolase L1 GTEx DepMap Descartes 3.50 3025.16


Dowload full table

UMAP plots showing activity of gene expression program identified in community:13. Neuroblastoma #5

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
TRAVAGLINI_LUNG_FIBROMYOCYTE_CELL 2.63e-06 51.58 12.40 3.53e-04 1.77e-03
4XIST, PLXNA4, PRUNE2, HHIP
 25
ZHONG_PFC_MAJOR_TYPES_EXCITATORY_NEURON 4.28e-04 86.37 8.33 1.51e-02 2.88e-01
2RBFOX1, PPP2R2B
 8
HU_FETAL_RETINA_HORIZONTAL 1.81e-05 30.14 7.49 1.35e-03 1.22e-02
4RTN1, CNTNAP2, RORB, STMN2
 40
LAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2 2.16e-05 17.14 5.17 1.45e-03 1.45e-02
5NRG3, PRUNE2, RBFOX1, SLIT3, L3MBTL4
 86
TRAVAGLINI_LUNG_NEUROENDOCRINE_CELL 1.04e-05 13.97 4.77 8.73e-04 6.98e-03
6NEGR1, RALYL, DGKB, STMN2, PCSK1N, UCHL1
 128
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_GLOBOSE_BASAL_CELLS 3.53e-04 24.91 4.72 1.32e-02 2.37e-01
3RTN1, STMN2, UCHL1
 35
DESCARTES_FETAL_LUNG_VISCERAL_NEURONS 1.50e-06 11.67 4.67 3.16e-04 1.01e-03
8SLC44A5, EPHA5, RORB, STMN2, UNC5D, RBFOX1, PPP2R2B, CHRM2
 212
DESCARTES_FETAL_STOMACH_ENS_NEURONS 2.04e-04 15.52 3.95 9.14e-03 1.37e-01
4CNTNAP2, STMN2, NPY, UCHL1
 74
LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES 3.05e-05 11.43 3.92 1.86e-03 2.05e-02
6DGKB, INPP4B, DLC1, DMD, SLIT3, SLC8A1
 155
MANNO_MIDBRAIN_NEUROTYPES_HOMTN 1.89e-06 8.25 3.65 3.16e-04 1.27e-03
10ADCY2, RTN1, PLXNA4, CNTNAP2, STMN2, RBFOX1, PPP2R2B, CHRM2, SLIT3, UCHL1
 389
MANNO_MIDBRAIN_NEUROTYPES_HNBGABA 1.94e-07 7.06 3.50 6.51e-05 1.30e-04
14XIST, ADCY2, RTN1, NEGR1, RALYL, PLXNA4, PDE11A, EPHA5, CNTNAP2, STMN2, RBFOX1, NDST3, SLC8A1, UCHL1
 703
FAN_EMBRYONIC_CTX_BIG_GROUPS_EXCITATORY_NEURON 8.44e-04 18.11 3.48 2.70e-02 5.66e-01
3PLXNA4, RBFOX1, PPP2R2B
 47
MANNO_MIDBRAIN_NEUROTYPES_HSERT 6.63e-06 7.10 3.15 7.41e-04 4.45e-03
10RTN1, NEGR1, RALYL, PDE11A, STMN2, RBFOX1, PPP2R2B, APBA1, PCSK1N, UCHL1
 450
MANNO_MIDBRAIN_NEUROTYPES_HGABA 1.83e-07 5.92 3.08 6.51e-05 1.23e-04
17XIST, RTN1, NEGR1, RALYL, PLXNA4, PDE11A, CNTNAP2, ITGA8, STMN2, RBFOX1, PPP2R2B, PCP4, APBA1, LGR5, NDST3, SLC8A1, UCHL1
 1105
DESCARTES_FETAL_LUNG_STROMAL_CELLS 1.33e-03 15.33 2.96 3.58e-02 8.94e-01
3PRR16, FREM1, ITGA8
 55
MANNO_MIDBRAIN_NEUROTYPES_HDA1 9.39e-06 6.16 2.83 8.73e-04 6.30e-03
11ADCY2, RTN1, NEGR1, RALYL, PLXNA4, EPHA5, STMN2, APBA1, PCSK1N, SLC8A1, UCHL1
 584
HU_FETAL_RETINA_RGC 4.15e-05 6.32 2.69 2.32e-03 2.79e-02
9RTN1, RALYL, EPHA5, PRUNE2, STMN2, NRCAM, PPP2R2B, PCSK1N, UCHL1
 443
HU_FETAL_RETINA_AMACRINE 2.06e-03 13.07 2.53 5.16e-02 1.00e+00
3RTN1, RORB, STMN2
 64
TRAVAGLINI_LUNG_MYOFIBROBLAST_CELL 2.15e-03 12.86 2.49 5.16e-02 1.00e+00
3TSPAN8, CD9, PCSK1N
 65
DESCARTES_FETAL_MUSCLE_SCHWANN_CELLS 1.15e-03 9.62 2.47 3.35e-02 7.70e-01
4EPHA5, PPP2R2B, KCNH5, PMP22
 117

Dowload full table

mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_UV_RESPONSE_DN 2.44e-03 7.76 2.00 1.22e-01 1.22e-01
4INPP4B, DLC1, ANXA2, PMP22
 144
HALLMARK_HEDGEHOG_SIGNALING 8.94e-03 15.30 1.73 2.24e-01 4.47e-01
2RTN1, NRCAM
 36
HALLMARK_KRAS_SIGNALING_UP 4.35e-02 4.05 0.80 7.25e-01 1.00e+00
3HDAC9, PCP4, PCSK1N
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2PCP4, CD9
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2SLIT3, PMP22
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1CD9
 74
HALLMARK_IL6_JAK_STAT3_SIGNALING 2.93e-01 2.97 0.07 1.00e+00 1.00e+00
1CD9
 87
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1TSPAN8
 96
HALLMARK_ANDROGEN_RESPONSE 3.28e-01 2.58 0.06 1.00e+00 1.00e+00
1INPP4B
 100
HALLMARK_PI3K_AKT_MTOR_SIGNALING 3.41e-01 2.45 0.06 1.00e+00 1.00e+00
1ADCY2
 105
HALLMARK_SPERMATOGENESIS 4.15e-01 1.90 0.05 1.00e+00 1.00e+00
1PCSK1N
 135
HALLMARK_COAGULATION 4.22e-01 1.86 0.05 1.00e+00 1.00e+00
1CD9
 138
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1XIST
 158
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ANXA2
 200
HALLMARK_G2M_CHECKPOINT 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1DMD
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1DLC1
 200
HALLMARK_MYOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1DMD
 200
HALLMARK_APICAL_JUNCTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1NEGR1
 200
HALLMARK_COMPLEMENT 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1L3MBTL4
 200
HALLMARK_MTORC1_SIGNALING 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CD9
 200

Dowload full table

KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_DILATED_CARDIOMYOPATHY 4.31e-04 12.63 3.23 8.02e-02 8.02e-02
4ADCY2, ITGA8, DMD, SLC8A1
 90
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 3.11e-03 11.23 2.19 1.93e-01 5.79e-01
3ITGA8, DMD, SLC8A1
 74
KEGG_CELL_ADHESION_MOLECULES_CAMS 1.83e-03 8.43 2.17 1.70e-01 3.41e-01
4NEGR1, CNTNAP2, ITGA8, NRCAM
 133
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 4.29e-03 9.97 1.94 2.00e-01 7.98e-01
3ITGA8, DMD, SLC8A1
 83
KEGG_AXON_GUIDANCE 1.42e-02 6.33 1.24 5.30e-01 1.00e+00
3EPHA5, UNC5D, SLIT3
 129
KEGG_CALCIUM_SIGNALING_PATHWAY 3.26e-02 4.56 0.90 9.67e-01 1.00e+00
3ADCY2, CHRM2, SLC8A1
 178
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 3.64e-02 7.04 0.81 9.67e-01 1.00e+00
2DGKB, INPP4B
 76
KEGG_PURINE_METABOLISM 1.29e-01 3.32 0.39 1.00e+00 1.00e+00
2ADCY2, PDE11A
 159
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 2.03e-01 2.47 0.29 1.00e+00 1.00e+00
2ITGA8, CHRM2
 213
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE 9.85e-02 10.19 0.24 1.00e+00 1.00e+00
1NDST3
 26
KEGG_BASE_EXCISION_REPAIR 1.30e-01 7.50 0.18 1.00e+00 1.00e+00
1PARP4
 35
KEGG_GLYCEROLIPID_METABOLISM 1.77e-01 5.31 0.13 1.00e+00 1.00e+00
1DGKB
 49
KEGG_INOSITOL_PHOSPHATE_METABOLISM 1.94e-01 4.81 0.12 1.00e+00 1.00e+00
1INPP4B
 54
KEGG_BASAL_CELL_CARCINOMA 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1HHIP
 55
KEGG_HEDGEHOG_SIGNALING_PATHWAY 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1HHIP
 56
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 2.34e-01 3.86 0.09 1.00e+00 1.00e+00
1NPY
 67
KEGG_VIRAL_MYOCARDITIS 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1DMD
 70
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 2.64e-01 3.36 0.08 1.00e+00 1.00e+00
1DGKB
 77
KEGG_CARDIAC_MUSCLE_CONTRACTION 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1SLC8A1
 79
KEGG_ECM_RECEPTOR_INTERACTION 2.84e-01 3.07 0.08 1.00e+00 1.00e+00
1ITGA8
 84

Dowload full table

CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr9q21 3.74e-02 4.31 0.85 1.00e+00 1.00e+00
3RORB, PRUNE2, APBA1
 188
chr7p21 4.26e-02 6.43 0.74 1.00e+00 1.00e+00
2DGKB, HDAC9
 83
chr14q23 8.59e-02 4.27 0.50 1.00e+00 1.00e+00
2RTN1, KCNH5
 124
chr12q21 9.06e-02 4.13 0.48 1.00e+00 1.00e+00
2TSPAN8, LGR5
 128
chr4q31 1.27e-01 3.36 0.39 1.00e+00 1.00e+00
2INPP4B, HHIP
 157
chr8q21 1.55e-01 2.96 0.35 1.00e+00 1.00e+00
2RALYL, STMN2
 178
chr1p31 2.09e-01 2.42 0.28 1.00e+00 1.00e+00
2NEGR1, SLC44A5
 217
chr4p13 1.16e-01 8.50 0.20 1.00e+00 1.00e+00
1UCHL1
 31
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1DLC1
 45
chr7q33 1.87e-01 5.00 0.12 1.00e+00 1.00e+00
1CHRM2
 52
chr4q26 1.90e-01 4.91 0.12 1.00e+00 1.00e+00
1NDST3
 53
chr17p12 2.22e-01 4.11 0.10 1.00e+00 1.00e+00
1PMP22
 63
chr10p13 2.25e-01 4.05 0.10 1.00e+00 1.00e+00
1ITGA8
 64
chr7q35 2.28e-01 3.99 0.10 1.00e+00 1.00e+00
1CNTNAP2
 65
chr8p12 2.34e-01 3.86 0.09 1.00e+00 1.00e+00
1UNC5D
 67
chrXp21 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1DMD
 82
chr7q32 3.01e-01 2.87 0.07 1.00e+00 1.00e+00
1PLXNA4
 90
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1NPY
 96
chr2p22 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1SLC8A1
 98
chr5q23 3.57e-01 2.32 0.06 1.00e+00 1.00e+00
1PRR16
 111

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
LHX3_01 3.05e-05 9.04 3.40 3.45e-02 3.45e-02
7RORB, ITGA8, HHIP, RBFOX1, PPP2R2B, DMD, KCNH5
 232
SOX9_B1 3.13e-04 7.35 2.53 8.86e-02 3.54e-01
6HDAC9, DLC1, EGFLAM, PPP2R2B, DMD, APBA1
 238
HFH1_01 4.13e-04 6.96 2.40 9.36e-02 4.68e-01
6RALYL, HHIP, RBFOX1, PPP2R2B, DMD, SLIT3
 251
YWATTWNNRGCT_UNKNOWN 2.77e-03 11.73 2.28 1.57e-01 1.00e+00
3HDAC9, RBFOX1, DMD
 71
YTAATTAA_LHX3_01 9.02e-04 7.43 2.27 1.24e-01 1.00e+00
5RORB, DLC1, ITGA8, HHIP, DMD
 192
CDC5_01 5.58e-04 6.56 2.26 1.05e-01 6.33e-01
6DGKB, INPP4B, SLC44A5, RORB, PPP2R2B, UCHL1
 266
YCATTAA_UNKNOWN 2.53e-04 4.92 2.09 8.86e-02 2.87e-01
9RTN1, INPP4B, RORB, PRUNE2, HHIP, RBFOX1, DMD, APBA1, DUOX1
 567
FOX_Q2 1.42e-03 6.68 2.05 1.24e-01 1.00e+00
5EGFLAM, RBFOX1, DMD, KCNH5, SLIT3
 213
TAATTA_CHX10_01 1.83e-04 4.34 2.00 8.86e-02 2.07e-01
11TSPAN8, RORB, DLC1, ITGA8, STMN2, EGFLAM, HHIP, RBFOX1, PPP2R2B, DMD, KCNH5
 823
WWTAAGGC_UNKNOWN 2.56e-03 7.65 1.97 1.57e-01 1.00e+00
4HDAC9, RORB, EGFLAM, RBFOX1
 146
OCT1_03 2.21e-03 6.01 1.85 1.57e-01 1.00e+00
5HDAC9, DLC1, RBFOX1, PPP2R2B, DMD
 236
CDPCR3HD_01 2.29e-03 5.96 1.83 1.57e-01 1.00e+00
5NEGR1, STMN2, RBFOX1, DMD, KCNH7
 238
NKX62_Q2 2.64e-03 5.76 1.77 1.57e-01 1.00e+00
5TSPAN8, STMN2, RBFOX1, DMD, SLIT3
 246
PTF1BETA_Q6 2.64e-03 5.76 1.77 1.57e-01 1.00e+00
5RALYL, HHIP, DMD, APBA1, PMP22
 246
RRAGTTGT_UNKNOWN 3.18e-03 5.51 1.69 1.57e-01 1.00e+00
5CNTNAP2, PRUNE2, HHIP, DMD, APBA1
 257
AREB6_02 3.28e-03 5.47 1.68 1.57e-01 1.00e+00
5RTN1, TSPAN8, DMD, PCP4, KCNH5
 259
CP2_01 3.33e-03 5.45 1.67 1.57e-01 1.00e+00
5RTN1, HDAC9, PRR16, PPP2R2B, PMP22
 260
TST1_01 3.61e-03 5.34 1.64 1.57e-01 1.00e+00
5RTN1, RALYL, INPP4B, DMD, KCNH7
 265
PAX2_02 3.61e-03 5.34 1.64 1.57e-01 1.00e+00
5RTN1, STMN2, PPP2R2B, DMD, PMP22
 265
HSF1_01 4.28e-03 5.13 1.58 1.79e-01 1.00e+00
5RTN1, RORB, ITGA8, RBFOX1, DMD
 276

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_NEURONAL_ION_CHANNEL_CLUSTERING 8.35e-04 57.69 5.91 1.00e+00 1.00e+00
2CNTNAP2, NRCAM
 11
GOBP_NEGATIVE_CHEMOTAXIS 7.92e-04 18.54 3.56 1.00e+00 1.00e+00
3NRG3, PLXNA4, SLIT3
 46
GOBP_MYELIN_ASSEMBLY 2.54e-03 30.58 3.34 1.00e+00 1.00e+00
2CD9, PMP22
 19
GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION 3.40e-03 26.01 2.87 1.00e+00 1.00e+00
2DMD, SLC8A1
 22
GOBP_RESPONSE_TO_MUSCLE_STRETCH 3.40e-03 26.01 2.87 1.00e+00 1.00e+00
2DMD, SLC8A1
 22
GOBP_CAMP_MEDIATED_SIGNALING 1.88e-03 13.52 2.62 1.00e+00 1.00e+00
3ADCY2, PDE11A, EPHA5
 62
GOBP_TELENCEPHALON_DEVELOPMENT 2.67e-04 7.58 2.61 1.00e+00 1.00e+00
6NRG3, PLXNA4, EPHA5, CNTNAP2, NPY, SLC8A1
 231
GOBP_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING 5.10e-03 20.80 2.32 1.00e+00 1.00e+00
2DMD, SLC8A1
 27
GOBP_FOREBRAIN_DEVELOPMENT 4.19e-04 5.81 2.19 1.00e+00 1.00e+00
7NRG3, PLXNA4, EPHA5, CNTNAP2, DLC1, NPY, SLC8A1
 357
GOBP_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_ENDOPLASMIC_RETICULUM 8.00e-03 16.26 1.84 1.00e+00 1.00e+00
2DMD, SLC8A1
 34
GOBP_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING 5.05e-03 9.38 1.83 1.00e+00 1.00e+00
3ADCY2, PDE11A, EPHA5
 88
GOBP_NEUROGENESIS 3.08e-04 3.36 1.70 1.00e+00 1.00e+00
15NRG3, NEGR1, PLXNA4, HDAC9, EPHA5, CNTNAP2, RORB, STMN2, NRCAM, UNC5D, HHIP, PCP4, SLIT3, CD9, NPY
 1613
GOBP_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE 9.43e-03 14.87 1.69 1.00e+00 1.00e+00
2PLXNA4, SLIT3
 37
GOBP_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY 1.04e-02 14.07 1.60 1.00e+00 1.00e+00
2ADCY2, LGR5
 39
GOBP_NEURON_PROJECTION_GUIDANCE 4.41e-03 5.09 1.56 1.00e+00 1.00e+00
5PLXNA4, EPHA5, NRCAM, UNC5D, SLIT3
 278
GOBP_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT 1.10e-02 13.70 1.56 1.00e+00 1.00e+00
2DMD, SLC8A1
 40
GOBP_RESPONSE_TO_MECHANICAL_STIMULUS 7.97e-03 5.49 1.42 1.00e+00 1.00e+00
4CNTNAP2, DMD, TMC2, SLC8A1
 202
GOBP_SECOND_MESSENGER_MEDIATED_SIGNALING 6.53e-03 4.61 1.42 1.00e+00 1.00e+00
5ADCY2, PDE11A, EPHA5, DMD, SLC8A1
 306
GOBP_AXON_EXTENSION 1.02e-02 7.19 1.41 1.00e+00 1.00e+00
3PLXNA4, NRCAM, SLIT3
 114
GOBP_NEURON_DIFFERENTIATION 2.58e-03 2.94 1.39 1.00e+00 1.00e+00
12NEGR1, PLXNA4, HDAC9, EPHA5, CNTNAP2, RORB, STMN2, NRCAM, UNC5D, PCP4, SLIT3, NPY
 1357

Dowload full table

Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE21670_UNTREATED_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_UP 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5RTN1, NRCAM, PARP4, CD9, SLC8A1
 200
GSE23321_CD8_STEM_CELL_MEMORY_VS_CENTRAL_MEMORY_CD8_TCELL_UP 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5NRG3, PRR16, DMD, KCNH5, BMPER
 200
GSE19923_E2A_KO_VS_HEB_AND_E2A_KO_DP_THYMOCYTE_DN 6.35e-03 5.87 1.52 1.00e+00 1.00e+00
4NRCAM, LGR5, NPY, PMP22
 189
GSE15659_TREG_VS_TCONV_UP 6.83e-03 5.75 1.49 1.00e+00 1.00e+00
4XIST, DMD, PCP4, DUOX1
 193
GSE22886_NEUTROPHIL_VS_MONOCYTE_UP 7.32e-03 5.63 1.46 1.00e+00 1.00e+00
4DLC1, NRCAM, PCP4, DUOX1
 197
GSE22886_NAIVE_CD8_TCELL_VS_NEUTROPHIL_DN 7.32e-03 5.63 1.46 1.00e+00 1.00e+00
4RORB, PRUNE2, STMN2, APBA1
 197
GSE13738_TCR_VS_BYSTANDER_ACTIVATED_CD4_TCELL_DN 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4PLXNA4, HDAC9, PPP2R2B, DMD
 198
GSE5589_WT_VS_IL6_KO_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4RTN1, DGKB, PRUNE2, PCP4
 199
GSE28783_CTRL_ANTI_MIR_VS_UNTREATED_ATHEROSCLEROSIS_MACROPHAGE_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4TSPAN8, CNTNAP2, DLC1, DMD
 199
GSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4EGFLAM, RBFOX1, NPY, DUOX1
 200
GSE19825_NAIVE_VS_DAY3_EFF_CD8_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4PRR16, HHIP, NPY, SLC8A1
 200
GSE369_SOCS3_KO_VS_WT_LIVER_POST_IL6_INJECTION_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4HDAC9, PCP4, LGR5, UCHL1
 200
GSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4CNTNAP2, PRUNE2, PPP2R2B, SLIT3
 200
GSE40274_EOS_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 1.20e-02 6.76 1.33 1.00e+00 1.00e+00
3XIST, PLXNA4, PRUNE2
 121
GSE14413_UNSTIM_VS_IFNB_STIM_RAW264_CELLS_DN 1.28e-02 6.59 1.29 1.00e+00 1.00e+00
3RTN1, SLC44A5, KCNH5
 124
GSE38697_LIGHT_ZONE_VS_DARK_ZONE_BCELL_DN 1.45e-02 6.28 1.23 1.00e+00 1.00e+00
3NEGR1, PRR16, NPY
 130
GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_48H_UP 2.26e-02 5.28 1.04 1.00e+00 1.00e+00
3XIST, TSPAN8, UNC5D
 154
GSE9601_UNTREATED_VS_NFKB_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP 2.70e-02 4.92 0.97 1.00e+00 1.00e+00
3PLXNA4, ANXA2, LGR5
 165
GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_24H_ACT_CD4_TCELL_UP 3.64e-02 4.36 0.86 1.00e+00 1.00e+00
3RTN1, FREM1, DLC1
 186
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP 3.69e-02 4.34 0.86 1.00e+00 1.00e+00
3RTN1, PLXNA4, SLIT3
 187

Dowload full table

Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
PLXNA4 11 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a semaphorin receptor that operates far upstream on the signaling cascade (PMID: 12591607).
HDAC9 12 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Histone deacetylase; likely to be a transcriptional cofactor
EPHA5 14 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RORB 17 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
L3MBTL4 47 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Histone modifier; polycomb protein.
NTRK1 63 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Membrane bound receptor protein
ZFPM2 69 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None FOG-proteins use some of their zinc-fingers to interact with the GATA proteins. Other C2H2 ZFs are probably also capable of binding DNA (PMID: 10329627).
MEIS1 77 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NR6A1 80 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HIF3A 94 Yes Inferred motif Obligate heteromer In vivo/Misc source None Binds DNA as a heterodimer with ARNT and ARNT2; reviewed in (PMID: 24099156).
PCSK6 97 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SOX6 135 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MYRFL 140 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Related to other MYRF TFs, which have related PBM motifs
PRKCB 143 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ZBTB20 144 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TBX3 155 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
KLF8 156 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
TERF1 165 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375).
NDN 169 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
CLU 174 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of NF-kappaB transcription factor activity, but there is no DBD and no evidence of DNA binding.

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB04_CGTAGGCCATCATCCC-1 Neurons:adrenal_medulla_cell_line 0.22 837.71
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.35, Neuroepithelial_cell:ESC-derived: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.26, iPS_cells:PDB_1lox-17Puro-10: 0.26, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Embryonic_stem_cells: 0.25, iPS_cells:skin_fibroblast-derived: 0.25
NB04_TTTACTGTCTGATTCT-1 Neurons:adrenal_medulla_cell_line 0.21 676.16
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.34, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.28, Smooth_muscle_cells:bronchial: 0.25, Embryonic_stem_cells: 0.25, Smooth_muscle_cells:bronchial:vit_D: 0.25, MSC: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.24, Smooth_muscle_cells:vascular: 0.24
NB04_GGGTTGCAGTAGCCGA-1 Neurons:adrenal_medulla_cell_line 0.24 630.47
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.4, Neuroepithelial_cell:ESC-derived: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.33, Neurons:ES_cell-derived_neural_precursor: 0.3, iPS_cells:PDB_1lox-21Puro-20: 0.28, iPS_cells:PDB_1lox-17Puro-10: 0.28, iPS_cells:PDB_1lox-21Puro-26: 0.28, Embryonic_stem_cells: 0.28, iPS_cells:PDB_1lox-17Puro-5: 0.28, iPS_cells:PDB_2lox-22: 0.27
NB04_GAACGGACAGCTGTAT-1 Neurons:adrenal_medulla_cell_line 0.18 610.52
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.2, iPS_cells:skin_fibroblast-derived: 0.2
NB04_TACACGACAAACGTGG-1 Neurons:adrenal_medulla_cell_line 0.19 553.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21
NB04_AACTTTCAGCTAACTC-1 Neurons:adrenal_medulla_cell_line 0.21 536.20
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_2lox-22: 0.23
NB04_CACCAGGCACCTCGGA-1 Neurons:adrenal_medulla_cell_line 0.19 522.30
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:skin_fibroblast-derived: 0.2
NB04_GCAATCAAGGGAGTAA-1 Neurons:adrenal_medulla_cell_line 0.18 481.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:skin_fibroblast-derived: 0.15
NB04_AGGGATGCACCAGGCT-1 Neurons:adrenal_medulla_cell_line 0.21 477.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB04_CTTGGCTAGCTTCGCG-1 Neurons:adrenal_medulla_cell_line 0.21 474.77
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:skin_fibroblast-derived: 0.21
NB04_ACGTCAAAGAACAACT-1 Neurons:adrenal_medulla_cell_line 0.20 457.25
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.2
NB04_GCTGCTTAGTAGATGT-1 Neurons:adrenal_medulla_cell_line 0.22 454.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.36, Astrocyte:Embryonic_stem_cell-derived: 0.3, Neuroepithelial_cell:ESC-derived: 0.3, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_2lox-22: 0.24
NB04_GCTGCAGCACTCGACG-1 Neurons:adrenal_medulla_cell_line 0.19 452.63
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, Embryonic_stem_cells: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, Neurons:Schwann_cell: 0.22
NB04_GCTTGAAGTAGCCTAT-1 Neurons:adrenal_medulla_cell_line 0.20 449.74
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:skin_fibroblast-derived: 0.19
NB04_ACGGGTCTCACCAGGC-1 Neurons:adrenal_medulla_cell_line 0.20 443.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.2, Neurons:Schwann_cell: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.19, Embryonic_stem_cells: 0.19, Smooth_muscle_cells:bronchial: 0.19
NB04_CTCCTAGAGTGACTCT-1 Neurons:adrenal_medulla_cell_line 0.19 433.52
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:skin_fibroblast-derived: 0.18
NB04_ACGGAGAAGGCCATAG-1 Neurons:adrenal_medulla_cell_line 0.19 433.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_2lox-22: 0.2
NB04_CGGACGTTCAGTTTGG-1 Neurons:adrenal_medulla_cell_line 0.19 432.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:skin_fibroblast-derived: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, Smooth_muscle_cells:bronchial: 0.17
NB04_CTGCCTATCCGTCATC-1 Neurons:adrenal_medulla_cell_line 0.20 429.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, Embryonic_stem_cells: 0.22, Smooth_muscle_cells:bronchial: 0.22
NB04_TGGTTCCTCGATCCCT-1 Neurons:adrenal_medulla_cell_line 0.21 425.16
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.32, Neuroepithelial_cell:ESC-derived: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.23, iPS_cells:PDB_1lox-17Puro-5: 0.23, Embryonic_stem_cells: 0.23, iPS_cells:PDB_2lox-22: 0.22
NB04_ACGATGTTCAGTTTGG-1 Neurons:adrenal_medulla_cell_line 0.18 410.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.2
NB04_AACTGGTGTCGTGGCT-1 Neurons:adrenal_medulla_cell_line 0.19 406.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, Embryonic_stem_cells: 0.19, Smooth_muscle_cells:bronchial: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19
NB04_CTAGCCTTCCAAACAC-1 Neurons:adrenal_medulla_cell_line 0.20 403.14
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:skin_fibroblast-derived: 0.2
NB04_TCGTAGATCCTAGTGA-1 Neurons:adrenal_medulla_cell_line 0.19 396.97
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:skin_fibroblast-derived: 0.18
NB04_GTAACTGAGGACACCA-1 Neurons:adrenal_medulla_cell_line 0.19 378.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:skin_fibroblast-derived: 0.2
NB04_AACTCTTTCAACACGT-1 Neurons:adrenal_medulla_cell_line 0.21 373.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:skin_fibroblast-derived: 0.19
NB04_ATTACTCCAGCCACCA-1 Neurons:adrenal_medulla_cell_line 0.19 373.05
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.28, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB04_TGCGGGTAGTGGCACA-1 Neurons:adrenal_medulla_cell_line 0.19 362.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, Embryonic_stem_cells: 0.18, Smooth_muscle_cells:bronchial: 0.17
NB04_GGAATAAGTGTGCCTG-1 Neurons:adrenal_medulla_cell_line 0.19 341.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.19, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:skin_fibroblast-derived: 0.15
NB04_GGAATAACATAACCTG-1 Neurons:adrenal_medulla_cell_line 0.17 334.10
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Smooth_muscle_cells:bronchial: 0.16
NB04_ACACCAATCAGCATGT-1 Neurons:adrenal_medulla_cell_line 0.17 329.79
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.19, Embryonic_stem_cells: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.19, iPS_cells:PDB_1lox-21Puro-26: 0.19, iPS_cells:PDB_1lox-17Puro-5: 0.19, iPS_cells:skin_fibroblast-derived: 0.18
NB04_GAAACTCCATATGAGA-1 Neurons:adrenal_medulla_cell_line 0.18 326.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Neuroepithelial_cell:ESC-derived: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, Embryonic_stem_cells: 0.17, iPS_cells:skin_fibroblast-derived: 0.17
NB04_TTAGTTCTCAAACCAC-1 Neurons:adrenal_medulla_cell_line 0.16 324.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Endothelial_cells:HUVEC:VEGF: 0.16, Endothelial_cells:HUVEC: 0.15, Endothelial_cells:lymphatic: 0.15, iPS_cells:CRL2097_foreskin: 0.15, Smooth_muscle_cells:bronchial: 0.15, Tissue_stem_cells:CD326-CD56+: 0.15
NB04_CAAGAAAGTGTTGAGG-1 Neurons:adrenal_medulla_cell_line 0.19 316.64
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.21, iPS_cells:PDB_1lox-17Puro-10: 0.21, iPS_cells:PDB_1lox-17Puro-5: 0.21, iPS_cells:PDB_1lox-21Puro-26: 0.21, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.2
NB04_TGCGGGTTCACATAGC-1 Neurons:adrenal_medulla_cell_line 0.17 308.84
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB04_ACGAGCCTCTTTACAC-1 Neurons:adrenal_medulla_cell_line 0.21 308.52
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.24, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21
NB04_GTTCTCGGTCTCCATC-1 Neurons:adrenal_medulla_cell_line 0.17 305.18
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, Tissue_stem_cells:CD326-CD56+: 0.15
NB04_CGAGCACCATTAGGCT-1 Neurons:adrenal_medulla_cell_line 0.18 295.89
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, Smooth_muscle_cells:bronchial: 0.15, Embryonic_stem_cells: 0.15
NB04_AGTAGTCTCTCTGAGA-1 Neurons:adrenal_medulla_cell_line 0.18 294.99
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.3, Neuroepithelial_cell:ESC-derived: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.23, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.21
NB04_CTGATAGCAAACCCAT-1 Neurons:adrenal_medulla_cell_line 0.18 292.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.28, Neuroepithelial_cell:ESC-derived: 0.28, Neurons:ES_cell-derived_neural_precursor: 0.25, Neurons:Schwann_cell: 0.24, Smooth_muscle_cells:bronchial: 0.23, Embryonic_stem_cells: 0.23, Smooth_muscle_cells:bronchial:vit_D: 0.23, iPS_cells:PDB_1lox-17Puro-10: 0.23, iPS_cells:CRL2097_foreskin: 0.23
NB04_CAGCCGACATAGACTC-1 Neurons:adrenal_medulla_cell_line 0.18 292.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_2lox-22: 0.15
NB04_CCGTTCAGTCTTTCAT-1 Neurons:adrenal_medulla_cell_line 0.15 289.76
Raw ScoresAstrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, Smooth_muscle_cells:bronchial: 0.14
NB04_CCTTCCCCAATCACAC-1 Neurons:adrenal_medulla_cell_line 0.20 287.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.29, Astrocyte:Embryonic_stem_cell-derived: 0.25, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.23, Embryonic_stem_cells: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.2, iPS_cells:PDB_1lox-21Puro-20: 0.2, iPS_cells:PDB_1lox-21Puro-26: 0.2, iPS_cells:PDB_1lox-17Puro-5: 0.2, iPS_cells:PDB_2lox-22: 0.19
NB04_AAGACCTGTCATATGC-1 Neurons:adrenal_medulla_cell_line 0.19 283.43
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neuroepithelial_cell:ESC-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.2, Embryonic_stem_cells: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_2lox-22: 0.17
NB04_GACACGCGTCTCCCTA-1 Neurons:adrenal_medulla_cell_line 0.20 281.67
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.22, Neuroepithelial_cell:ESC-derived: 0.22, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:skin_fibroblast-derived: 0.16
NB04_TGAGGGATCTTGCATT-1 Neurons:adrenal_medulla_cell_line 0.15 281.28
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:skin_fibroblast-derived: 0.14
NB04_CTCTGGTTCGTAGATC-1 Neurons:adrenal_medulla_cell_line 0.17 280.83
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.21, Neuroepithelial_cell:ESC-derived: 0.21, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, Embryonic_stem_cells: 0.17, iPS_cells:PDB_2lox-22: 0.17
NB04_ATTACTCAGTGGACGT-1 Neurons:adrenal_medulla_cell_line 0.16 279.52
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.11, Embryonic_stem_cells: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, Smooth_muscle_cells:bronchial: 0.11
NB04_GCTTCCAGTTAGGGTG-1 Neurons:adrenal_medulla_cell_line 0.20 270.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_2lox-22: 0.24
NB04_CGAGCCAGTGTATGGG-1 Neurons:adrenal_medulla_cell_line 0.16 267.76
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.23, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.2, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-5: 0.18, Embryonic_stem_cells: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_2lox-22: 0.17


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.51e-05
Mean rank of genes in gene set: 2136.09
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RTN1 0.0112144 4 GTEx DepMap Descartes 8.99 3944.17
STMN2 0.0071857 22 GTEx DepMap Descartes 8.08 6150.03
UCHL1 0.0048998 50 GTEx DepMap Descartes 3.50 3025.16
DBH 0.0027539 122 GTEx DepMap Descartes 1.43 706.94
RGS5 0.0023928 152 GTEx DepMap Descartes 1.60 404.59
ELAVL4 0.0008564 672 GTEx DepMap Descartes 1.99 632.88
MAP1B 0.0004412 1370 GTEx DepMap Descartes 2.39 241.82
MLLT11 0.0002738 2027 GTEx DepMap Descartes 0.82 499.18
NRG1 0.0002675 2063 GTEx DepMap Descartes 6.96 696.88
TH 0.0000028 4586 GTEx DepMap Descartes 0.87 579.26
ISL1 -0.0012264 12429 GTEx DepMap Descartes 0.28 150.15


SCPs mouse and neuroblastoma (Olsen)
Similar to above, but for genes common to neuroblastoma SCP-like cells (as determined from their UMAP plot) and mouse SCP cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.58e-04
Mean rank of genes in gene set: 2581.18
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PLP1 0.0014400 341 GTEx DepMap Descartes 0.02 10.26
S100B 0.0011987 439 GTEx DepMap Descartes 0.04 54.17
GPM6B 0.0011814 446 GTEx DepMap Descartes 0.26 89.67
LGI4 0.0008225 697 GTEx DepMap Descartes 0.02 13.21
ERBB3 0.0007938 733 GTEx DepMap Descartes 0.03 8.72
DST 0.0007369 805 GTEx DepMap Descartes 2.45 137.29
MPZ 0.0004423 1366 GTEx DepMap Descartes 0.02 19.84
SEMA3B 0.0003304 1737 GTEx DepMap Descartes 0.04 17.14
FXYD1 0.0002395 2219 GTEx DepMap Descartes 0.01 8.55
CNN3 -0.0003022 9718 GTEx DepMap Descartes 0.12 90.65
NRXN1 -0.0003148 9892 GTEx DepMap Descartes 1.77 199.36


N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.49e-03
Mean rank of genes in gene set: 3586.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
LGR5 0.0057378 39 GTEx DepMap Descartes 0.62 187.94
SLCO3A1 0.0047733 52 GTEx DepMap Descartes 2.54 672.41
SYN2 0.0043728 59 GTEx DepMap Descartes 1.08 362.23
SCG5 0.0017861 249 GTEx DepMap Descartes 0.72 804.11
SNAP25 0.0011422 470 GTEx DepMap Descartes 0.98 627.94
PPFIA2 0.0009184 617 GTEx DepMap Descartes 0.63 137.08
GNAS 0.0008946 634 GTEx DepMap Descartes 2.42 809.14
PCLO 0.0005568 1093 GTEx DepMap Descartes 1.78 115.58
NAP1L5 0.0003958 1497 GTEx DepMap Descartes 0.12 102.67
SCG3 0.0002840 1975 GTEx DepMap Descartes 0.29 127.21
ADCYAP1R1 0.0001589 2795 GTEx DepMap Descartes 0.15 29.03
CELF4 -0.0000742 5909 GTEx DepMap Descartes 1.46 474.34
CXCL14 -0.0001446 7310 GTEx DepMap Descartes 0.00 0.54
PTPRN -0.0003320 10096 GTEx DepMap Descartes 0.17 41.97
C1QL1 -0.0007045 12054 GTEx DepMap Descartes 0.02 8.02
CACNA2D1 -0.0019610 12535 GTEx DepMap Descartes 1.84 287.86




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 6821.58
Median rank of genes in gene set: 7450
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RTN1 0.0112144 4 GTEx DepMap Descartes 8.99 3944.17
STMN2 0.0071857 22 GTEx DepMap Descartes 8.08 6150.03
NRCAM 0.0068390 24 GTEx DepMap Descartes 2.97 608.56
SLIT3 0.0057108 40 GTEx DepMap Descartes 4.06 571.08
NPY 0.0052656 45 GTEx DepMap Descartes 11.40 22947.15
ELAVL2 0.0047405 53 GTEx DepMap Descartes 2.68 918.06
CADM1 0.0034047 91 GTEx DepMap Descartes 5.23 786.79
GRIA2 0.0031192 106 GTEx DepMap Descartes 2.16 534.49
TMOD1 0.0028338 118 GTEx DepMap Descartes 1.77 746.71
DBH 0.0027539 122 GTEx DepMap Descartes 1.43 706.94
SYT1 0.0025219 137 GTEx DepMap Descartes 5.65 1623.93
RGS5 0.0023928 152 GTEx DepMap Descartes 1.60 404.59
CLASP2 0.0022463 166 GTEx DepMap Descartes 3.00 556.21
DNER 0.0022111 173 GTEx DepMap Descartes 0.51 206.33
GAP43 0.0021915 176 GTEx DepMap Descartes 1.27 944.98
PIK3R1 0.0021298 186 GTEx DepMap Descartes 0.75 146.52
RUNDC3B 0.0021171 190 GTEx DepMap Descartes 1.00 330.71
AP1S2 0.0020591 204 GTEx DepMap Descartes 0.45 198.86
MYRIP 0.0018709 234 GTEx DepMap Descartes 0.39 100.54
PHYHIPL 0.0017840 251 GTEx DepMap Descartes 0.58 222.10
QDPR 0.0016330 285 GTEx DepMap Descartes 0.53 520.27
GDAP1 0.0015626 304 GTEx DepMap Descartes 1.15 435.05
GATA2 0.0015257 318 GTEx DepMap Descartes 0.73 311.40
PTS 0.0015227 320 GTEx DepMap Descartes 0.40 521.74
OLFM1 0.0014701 334 GTEx DepMap Descartes 0.17 89.51
NCOA7 0.0013738 366 GTEx DepMap Descartes 1.05 NA
TUBB2A 0.0013623 369 GTEx DepMap Descartes 0.95 734.05
NELL2 0.0012342 425 GTEx DepMap Descartes 0.99 362.78
NCAM1 0.0012047 432 GTEx DepMap Descartes 1.04 231.53
DPYSL2 0.0012039 433 GTEx DepMap Descartes 1.76 496.57


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 6804.4
Median rank of genes in gene set: 7469
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DLC1 0.0078337 19 GTEx DepMap Descartes 12.04 2236.76
DMD 0.0063290 29 GTEx DepMap Descartes 2.66 264.58
ANXA2 0.0062281 31 GTEx DepMap Descartes 1.07 442.76
IGFBP5 0.0048659 51 GTEx DepMap Descartes 0.66 144.33
PAPSS2 0.0039358 71 GTEx DepMap Descartes 0.38 143.57
SDC2 0.0037475 76 GTEx DepMap Descartes 0.35 166.13
PDE3A 0.0036587 79 GTEx DepMap Descartes 1.26 235.81
TMEFF2 0.0032431 98 GTEx DepMap Descartes 0.96 408.76
FLRT2 0.0030272 109 GTEx DepMap Descartes 0.44 16.81
PTN 0.0026836 126 GTEx DepMap Descartes 0.63 539.65
LIFR 0.0024675 147 GTEx DepMap Descartes 0.40 54.40
ROR1 0.0021971 175 GTEx DepMap Descartes 0.33 76.61
CD44 0.0018213 241 GTEx DepMap Descartes 1.07 271.69
PALLD 0.0017795 253 GTEx DepMap Descartes 0.67 155.49
LPP 0.0017261 262 GTEx DepMap Descartes 1.06 72.91
GNG12 0.0016471 278 GTEx DepMap Descartes 0.13 38.76
OLFML2A 0.0016465 279 GTEx DepMap Descartes 0.04 7.99
ATP1B1 0.0016200 286 GTEx DepMap Descartes 0.90 446.62
GAS2 0.0016167 289 GTEx DepMap Descartes 0.25 163.75
CRISPLD1 0.0016013 294 GTEx DepMap Descartes 0.14 45.82
LAPTM4A 0.0015826 299 GTEx DepMap Descartes 0.43 454.96
PLK2 0.0015112 324 GTEx DepMap Descartes 0.14 69.85
DKK3 0.0014809 331 GTEx DepMap Descartes 0.14 17.22
B2M 0.0014381 342 GTEx DepMap Descartes 1.48 932.16
ATP2B4 0.0013555 371 GTEx DepMap Descartes 0.60 85.89
ITM2B 0.0012151 428 GTEx DepMap Descartes 0.87 117.27
SH3BGRL 0.0011935 441 GTEx DepMap Descartes 0.17 147.37
MANF 0.0011171 488 GTEx DepMap Descartes 0.21 201.17
FGFR1 0.0010588 515 GTEx DepMap Descartes 0.22 47.70
ADAM19 0.0009878 568 GTEx DepMap Descartes 0.24 47.05


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.42e-01
Mean rank of genes in gene set: 5629.36
Median rank of genes in gene set: 4576.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PAPSS2 0.0039358 71 GTEx DepMap Descartes 0.38 143.57
SGCZ 0.0037986 74 GTEx DepMap Descartes 1.15 203.23
DNER 0.0022111 173 GTEx DepMap Descartes 0.51 206.33
CLU 0.0022034 174 GTEx DepMap Descartes 0.85 401.84
SH3BP5 0.0005076 1211 GTEx DepMap Descartes 0.16 68.97
SH3PXD2B 0.0004625 1316 GTEx DepMap Descartes 0.15 27.20
INHA 0.0004162 1432 GTEx DepMap Descartes 0.02 18.64
FDX1 0.0002369 2229 GTEx DepMap Descartes 0.05 22.83
POR 0.0001908 2538 GTEx DepMap Descartes 0.13 66.46
JAKMIP2 0.0001825 2614 GTEx DepMap Descartes 0.57 79.01
NPC1 0.0001800 2633 GTEx DepMap Descartes 0.21 58.34
SCAP 0.0001702 2703 GTEx DepMap Descartes 0.20 59.75
GSTA4 0.0001680 2725 GTEx DepMap Descartes 0.24 179.94
FREM2 0.0001368 2975 GTEx DepMap Descartes 0.01 0.86
SLC1A2 0.0001324 3013 GTEx DepMap Descartes 0.32 33.19
MSMO1 0.0001167 3166 GTEx DepMap Descartes 0.14 81.18
IGF1R 0.0001090 3246 GTEx DepMap Descartes 0.97 97.24
GRAMD1B 0.0000273 4219 GTEx DepMap Descartes 0.06 10.42
TM7SF2 -0.0000188 4934 GTEx DepMap Descartes 0.08 51.63
FRMD5 -0.0000368 5220 GTEx DepMap Descartes 1.15 278.60
STAR -0.0001018 6446 GTEx DepMap Descartes 0.00 0.18
SLC16A9 -0.0001077 6576 GTEx DepMap Descartes 0.10 32.18
DHCR7 -0.0001172 6780 GTEx DepMap Descartes 0.02 12.92
HMGCS1 -0.0001919 8115 GTEx DepMap Descartes 0.11 23.21
FDPS -0.0002550 9099 GTEx DepMap Descartes 0.24 150.97
CYB5B -0.0002761 9369 GTEx DepMap Descartes 0.14 42.42
LDLR -0.0003250 10013 GTEx DepMap Descartes 0.05 9.94
BAIAP2L1 -0.0003407 10174 GTEx DepMap Descartes 0.02 4.75
ERN1 -0.0003603 10351 GTEx DepMap Descartes 0.02 3.88
SCARB1 -0.0003723 10465 GTEx DepMap Descartes 0.06 12.61


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.62e-04
Mean rank of genes in gene set: 4315.98
Median rank of genes in gene set: 1157
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC44A5 0.0094667 10 GTEx DepMap Descartes 3.28 1089.30
PLXNA4 0.0093830 11 GTEx DepMap Descartes 2.16 225.01
STMN2 0.0071857 22 GTEx DepMap Descartes 8.08 6150.03
RBFOX1 0.0064753 27 GTEx DepMap Descartes 10.18 2776.81
NPY 0.0052656 45 GTEx DepMap Descartes 11.40 22947.15
ELAVL2 0.0047405 53 GTEx DepMap Descartes 2.68 918.06
NTRK1 0.0042992 63 GTEx DepMap Descartes 0.79 363.58
TMEFF2 0.0032431 98 GTEx DepMap Descartes 0.96 408.76
RYR2 0.0031552 104 GTEx DepMap Descartes 5.50 437.18
GAP43 0.0021915 176 GTEx DepMap Descartes 1.27 944.98
SLC6A2 0.0021901 177 GTEx DepMap Descartes 0.64 274.18
IL7 0.0020249 208 GTEx DepMap Descartes 2.32 1503.83
EYA4 0.0015827 298 GTEx DepMap Descartes 1.27 335.10
TUBB2A 0.0013623 369 GTEx DepMap Descartes 0.95 734.05
KCNB2 0.0011236 481 GTEx DepMap Descartes 1.79 586.96
TUBA1A 0.0010700 508 GTEx DepMap Descartes 4.85 3484.37
CNTFR 0.0010235 543 GTEx DepMap Descartes 0.34 215.32
MAB21L1 0.0008025 722 GTEx DepMap Descartes 0.28 137.73
REEP1 0.0007547 782 GTEx DepMap Descartes 0.39 122.17
EPHA6 0.0005874 1030 GTEx DepMap Descartes 0.98 294.32
RGMB 0.0005280 1157 GTEx DepMap Descartes 0.47 147.90
GREM1 0.0005123 1188 GTEx DepMap Descartes 0.04 3.43
BASP1 0.0004761 1285 GTEx DepMap Descartes 1.16 863.41
MAP1B 0.0004412 1370 GTEx DepMap Descartes 2.39 241.82
PTCHD1 0.0002998 1881 GTEx DepMap Descartes 0.21 23.97
MLLT11 0.0002738 2027 GTEx DepMap Descartes 0.82 499.18
TUBB2B 0.0002001 2480 GTEx DepMap Descartes 2.07 1434.15
GAL 0.0001952 2509 GTEx DepMap Descartes 0.55 1143.83
RPH3A -0.0002736 9328 GTEx DepMap Descartes 0.02 3.84
MAB21L2 -0.0005274 11527 GTEx DepMap Descartes 0.09 49.42


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.49e-01
Mean rank of genes in gene set: 6499.08
Median rank of genes in gene set: 7226.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MYRIP 0.0018709 234 GTEx DepMap Descartes 0.39 100.54
PTPRB 0.0017149 263 GTEx DepMap Descartes 0.32 37.76
ROBO4 0.0012453 418 GTEx DepMap Descartes 0.05 15.61
TEK 0.0008274 692 GTEx DepMap Descartes 0.08 24.61
CYP26B1 0.0005290 1155 GTEx DepMap Descartes 0.03 8.10
ARHGAP29 0.0004633 1311 GTEx DepMap Descartes 0.23 29.64
CEACAM1 0.0004496 1346 GTEx DepMap Descartes 0.06 26.94
RAMP2 0.0001801 2632 GTEx DepMap Descartes 0.10 177.02
BTNL9 0.0001617 2772 GTEx DepMap Descartes 0.01 2.74
RASIP1 0.0000756 3602 GTEx DepMap Descartes 0.02 7.95
GALNT15 0.0000443 3976 GTEx DepMap Descartes 0.01 NA
MMRN2 0.0000127 4428 GTEx DepMap Descartes 0.01 3.84
EHD3 0.0000090 4498 GTEx DepMap Descartes 0.02 6.82
F8 -0.0000042 4694 GTEx DepMap Descartes 0.00 0.00
CRHBP -0.0000152 4881 GTEx DepMap Descartes 0.00 4.36
KANK3 -0.0000493 5435 GTEx DepMap Descartes 0.01 2.85
PLVAP -0.0000979 6367 GTEx DepMap Descartes 0.02 11.48
KDR -0.0000991 6394 GTEx DepMap Descartes 0.01 1.48
HYAL2 -0.0001340 7104 GTEx DepMap Descartes 0.04 12.13
NOTCH4 -0.0001471 7349 GTEx DepMap Descartes 0.02 3.96
TIE1 -0.0001488 7384 GTEx DepMap Descartes 0.01 4.02
CDH5 -0.0001845 7984 GTEx DepMap Descartes 0.01 3.06
ESM1 -0.0001974 8197 GTEx DepMap Descartes 0.00 1.63
NPR1 -0.0002086 8386 GTEx DepMap Descartes 0.00 0.00
FLT4 -0.0002242 8624 GTEx DepMap Descartes 0.00 0.95
SHE -0.0002447 8936 GTEx DepMap Descartes 0.00 0.14
TMEM88 -0.0002588 9148 GTEx DepMap Descartes 0.03 60.90
CLDN5 -0.0002751 9349 GTEx DepMap Descartes 0.01 3.51
SHANK3 -0.0002861 9495 GTEx DepMap Descartes 0.02 2.37
IRX3 -0.0002936 9598 GTEx DepMap Descartes 0.00 0.00


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.73e-01
Mean rank of genes in gene set: 7321.27
Median rank of genes in gene set: 9209
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FREM1 0.0081201 18 GTEx DepMap Descartes 1.10 164.38
HHIP 0.0066703 26 GTEx DepMap Descartes 0.80 109.48
GAS2 0.0016167 289 GTEx DepMap Descartes 0.25 163.75
CLDN11 0.0015493 311 GTEx DepMap Descartes 0.28 146.67
PAMR1 0.0014052 356 GTEx DepMap Descartes 0.14 68.60
ABCA6 0.0010274 541 GTEx DepMap Descartes 0.06 10.43
ADAMTSL3 0.0007670 760 GTEx DepMap Descartes 0.06 10.17
LRRC17 0.0003739 1561 GTEx DepMap Descartes 0.06 34.91
CCDC80 0.0001866 2579 GTEx DepMap Descartes 0.06 7.48
ADAMTS2 0.0001682 2721 GTEx DepMap Descartes 0.12 24.05
RSPO3 0.0001615 2774 GTEx DepMap Descartes 0.01 NA
EDNRA 0.0001323 3015 GTEx DepMap Descartes 0.03 9.75
POSTN 0.0000759 3596 GTEx DepMap Descartes 0.11 50.53
LAMC3 0.0000429 3989 GTEx DepMap Descartes 0.02 4.86
OGN 0.0000088 4505 GTEx DepMap Descartes 0.04 17.28
SCARA5 -0.0000021 4659 GTEx DepMap Descartes 0.00 0.53
ABCC9 -0.0000640 5722 GTEx DepMap Descartes 0.03 3.90
IGFBP3 -0.0000845 6126 GTEx DepMap Descartes 0.02 13.67
PCDH18 -0.0001202 6833 GTEx DepMap Descartes 0.00 0.00
ITGA11 -0.0002222 8593 GTEx DepMap Descartes 0.00 0.35
DKK2 -0.0002245 8632 GTEx DepMap Descartes 0.02 8.43
COL27A1 -0.0002558 9111 GTEx DepMap Descartes 0.02 2.77
LOX -0.0002710 9307 GTEx DepMap Descartes 0.00 0.00
C7 -0.0003015 9701 GTEx DepMap Descartes 0.02 4.37
GLI2 -0.0003049 9749 GTEx DepMap Descartes 0.01 1.03
CD248 -0.0003204 9963 GTEx DepMap Descartes 0.00 1.95
ACTA2 -0.0003706 10444 GTEx DepMap Descartes 0.04 27.19
PRRX1 -0.0003762 10497 GTEx DepMap Descartes 0.01 2.15
PDGFRA -0.0003818 10549 GTEx DepMap Descartes 0.00 0.03
SFRP2 -0.0003825 10559 GTEx DepMap Descartes 0.00 1.59


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.19e-01
Mean rank of genes in gene set: 7096.5
Median rank of genes in gene set: 9546.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCSK1N 0.0053008 43 GTEx DepMap Descartes 3.29 4528.42
GALNTL6 0.0037722 75 GTEx DepMap Descartes 1.30 466.35
CDH18 0.0033595 92 GTEx DepMap Descartes 1.25 366.03
CNTN3 0.0028108 119 GTEx DepMap Descartes 0.23 65.51
GRID2 0.0022510 164 GTEx DepMap Descartes 1.14 262.61
SLC18A1 0.0021236 188 GTEx DepMap Descartes 0.51 234.96
TBX20 0.0020265 207 GTEx DepMap Descartes 0.34 255.85
SLC35F3 0.0015883 296 GTEx DepMap Descartes 0.45 202.97
GRM7 0.0010949 497 GTEx DepMap Descartes 0.47 141.96
PACRG 0.0009111 620 GTEx DepMap Descartes 0.59 433.05
SPOCK3 0.0009058 622 GTEx DepMap Descartes 0.39 194.07
UNC80 0.0007880 737 GTEx DepMap Descartes 0.98 89.90
KSR2 0.0005104 1199 GTEx DepMap Descartes 0.47 34.41
SORCS3 0.0004205 1418 GTEx DepMap Descartes 0.05 10.45
DGKK 0.0001756 2667 GTEx DepMap Descartes 0.02 4.24
LAMA3 -0.0001464 7335 GTEx DepMap Descartes 0.06 8.05
PENK -0.0001628 7643 GTEx DepMap Descartes 0.00 0.00
CHGA -0.0002587 9145 GTEx DepMap Descartes 1.11 708.82
CDH12 -0.0002725 9318 GTEx DepMap Descartes 0.17 35.35
HTATSF1 -0.0003066 9775 GTEx DepMap Descartes 0.12 53.58
SLC24A2 -0.0003768 10506 GTEx DepMap Descartes 0.03 3.22
GCH1 -0.0003815 10547 GTEx DepMap Descartes 0.23 93.19
ROBO1 -0.0006128 11829 GTEx DepMap Descartes 2.13 316.76
ARC -0.0006485 11930 GTEx DepMap Descartes 0.01 4.02
AGBL4 -0.0006490 11932 GTEx DepMap Descartes 1.17 347.03
C1QL1 -0.0007045 12054 GTEx DepMap Descartes 0.02 8.02
NTNG1 -0.0007410 12127 GTEx DepMap Descartes 0.47 126.17
ST18 -0.0007847 12185 GTEx DepMap Descartes 0.01 3.18
MGAT4C -0.0009032 12300 GTEx DepMap Descartes 0.19 5.84
PCSK2 -0.0009731 12350 GTEx DepMap Descartes 0.07 16.90


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.83e-03
Mean rank of genes in gene set: 4482.93
Median rank of genes in gene set: 4119
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SOX6 0.0025262 135 GTEx DepMap Descartes 1.17 176.55
TSPAN5 0.0017364 261 GTEx DepMap Descartes 1.16 375.93
TFR2 0.0008692 655 GTEx DepMap Descartes 0.34 153.47
RHD 0.0007374 804 GTEx DepMap Descartes 0.06 28.37
ANK1 0.0006247 948 GTEx DepMap Descartes 0.28 41.10
BLVRB 0.0005617 1082 GTEx DepMap Descartes 0.05 49.16
XPO7 0.0004064 1465 GTEx DepMap Descartes 0.31 85.51
SPTB 0.0003680 1587 GTEx DepMap Descartes 0.09 10.14
EPB41 0.0002813 1991 GTEx DepMap Descartes 0.55 102.32
CPOX 0.0002203 2337 GTEx DepMap Descartes 0.05 23.03
DENND4A 0.0002145 2366 GTEx DepMap Descartes 0.62 96.64
CAT 0.0000891 3460 GTEx DepMap Descartes 0.06 32.79
SLC25A21 0.0000776 3574 GTEx DepMap Descartes 0.02 3.54
RGS6 0.0000400 4033 GTEx DepMap Descartes 0.02 3.85
RAPGEF2 0.0000339 4119 GTEx DepMap Descartes 0.50 85.01
FECH -0.0000255 5054 GTEx DepMap Descartes 0.06 10.32
ABCB10 -0.0000375 5233 GTEx DepMap Descartes 0.09 30.56
TMCC2 -0.0000605 5647 GTEx DepMap Descartes 0.02 6.25
MARCH3 -0.0000667 5776 GTEx DepMap Descartes 0.15 NA
SLC25A37 -0.0001016 6443 GTEx DepMap Descartes 0.10 25.17
GYPC -0.0001100 6625 GTEx DepMap Descartes 0.01 7.43
SLC4A1 -0.0001184 6809 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0001213 6853 GTEx DepMap Descartes 0.00 0.00
SELENBP1 -0.0001651 7679 GTEx DepMap Descartes 0.00 0.56
MICAL2 -0.0002267 8669 GTEx DepMap Descartes 0.03 6.30
TRAK2 -0.0002371 8831 GTEx DepMap Descartes 0.10 20.18
SNCA -0.0002522 9051 GTEx DepMap Descartes 0.12 40.08
SPECC1 -0.0002537 9074 GTEx DepMap Descartes 0.01 1.87
GCLC -0.0002820 9444 GTEx DepMap Descartes 0.09 34.47
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8266.26
Median rank of genes in gene set: 9447
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
AXL 0.0021778 180 GTEx DepMap Descartes 0.17 49.33
HRH1 0.0013173 384 GTEx DepMap Descartes 0.15 47.85
WWP1 0.0009384 601 GTEx DepMap Descartes 0.28 80.32
ADAP2 0.0006644 891 GTEx DepMap Descartes 0.08 38.84
CTSB 0.0002150 2362 GTEx DepMap Descartes 0.27 99.94
CD163L1 0.0000319 4144 GTEx DepMap Descartes 0.19 53.94
CPVL -0.0000054 4713 GTEx DepMap Descartes 0.05 35.85
RBPJ -0.0000205 4960 GTEx DepMap Descartes 0.52 107.45
LGMN -0.0000543 5533 GTEx DepMap Descartes 0.08 54.61
FGL2 -0.0000794 6019 GTEx DepMap Descartes 0.01 2.88
MARCH1 -0.0000901 6215 GTEx DepMap Descartes 0.13 NA
MS4A4A -0.0001272 6962 GTEx DepMap Descartes 0.00 2.94
CTSS -0.0001598 7579 GTEx DepMap Descartes 0.05 15.99
ABCA1 -0.0001978 8203 GTEx DepMap Descartes 0.06 8.26
SLC1A3 -0.0002047 8316 GTEx DepMap Descartes 0.01 4.50
CD163 -0.0002313 8742 GTEx DepMap Descartes 0.00 0.87
HCK -0.0002526 9058 GTEx DepMap Descartes 0.01 3.16
CYBB -0.0002655 9231 GTEx DepMap Descartes 0.00 2.24
IFNGR1 -0.0002752 9350 GTEx DepMap Descartes 0.07 31.37
CSF1R -0.0002898 9544 GTEx DepMap Descartes 0.01 2.09
FGD2 -0.0002945 9616 GTEx DepMap Descartes 0.01 1.95
MERTK -0.0002987 9660 GTEx DepMap Descartes 0.01 4.36
SLCO2B1 -0.0003007 9689 GTEx DepMap Descartes 0.01 1.62
SPP1 -0.0003072 9785 GTEx DepMap Descartes 0.52 421.40
ATP8B4 -0.0003647 10385 GTEx DepMap Descartes 0.02 4.16
PTPRE -0.0003932 10657 GTEx DepMap Descartes 0.07 11.97
CTSC -0.0003985 10699 GTEx DepMap Descartes 0.01 2.04
SLC9A9 -0.0004707 11240 GTEx DepMap Descartes 0.03 11.08
CD14 -0.0005259 11518 GTEx DepMap Descartes 0.00 3.81
TGFBI -0.0005439 11603 GTEx DepMap Descartes 0.03 5.55


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.28e-03
Mean rank of genes in gene set: 4792.84
Median rank of genes in gene set: 1574
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EGFLAM 0.0070545 23 GTEx DepMap Descartes 0.84 251.21
PPP2R2B 0.0064107 28 GTEx DepMap Descartes 2.42 303.16
PMP22 0.0052437 46 GTEx DepMap Descartes 1.34 1051.51
XKR4 0.0041392 65 GTEx DepMap Descartes 0.89 58.47
PTN 0.0026836 126 GTEx DepMap Descartes 0.63 539.65
SCN7A 0.0024841 142 GTEx DepMap Descartes 0.58 110.41
IL1RAPL2 0.0022255 171 GTEx DepMap Descartes 0.26 124.64
PTPRZ1 0.0021653 183 GTEx DepMap Descartes 0.05 9.13
COL25A1 0.0021216 189 GTEx DepMap Descartes 0.13 24.50
GRIK3 0.0019559 219 GTEx DepMap Descartes 0.11 15.02
OLFML2A 0.0016465 279 GTEx DepMap Descartes 0.04 7.99
PLP1 0.0014400 341 GTEx DepMap Descartes 0.02 10.26
SLC35F1 0.0012879 396 GTEx DepMap Descartes 0.15 38.44
PAG1 0.0009448 595 GTEx DepMap Descartes 0.77 92.69
ERBB3 0.0007938 733 GTEx DepMap Descartes 0.03 8.72
DST 0.0007369 805 GTEx DepMap Descartes 2.45 137.29
NRXN3 0.0006074 977 GTEx DepMap Descartes 0.33 46.52
SFRP1 0.0005750 1048 GTEx DepMap Descartes 0.15 46.49
EDNRB 0.0005503 1104 GTEx DepMap Descartes 0.01 3.74
MPZ 0.0004423 1366 GTEx DepMap Descartes 0.02 19.84
STARD13 0.0004268 1402 GTEx DepMap Descartes 0.11 24.23
IL1RAPL1 0.0003952 1500 GTEx DepMap Descartes 0.30 83.29
KCTD12 0.0003534 1648 GTEx DepMap Descartes 0.06 20.33
HMGA2 0.0003066 1841 GTEx DepMap Descartes 0.02 3.40
TRPM3 0.0001339 3000 GTEx DepMap Descartes 0.21 18.09
MDGA2 -0.0000347 5189 GTEx DepMap Descartes 0.00 0.43
VCAN -0.0001011 6431 GTEx DepMap Descartes 0.20 20.37
PLCE1 -0.0001112 6647 GTEx DepMap Descartes 0.06 5.27
COL18A1 -0.0001115 6653 GTEx DepMap Descartes 0.17 28.32
ADAMTS5 -0.0002167 8515 GTEx DepMap Descartes 0.01 0.91


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.95e-01
Mean rank of genes in gene set: 6951.38
Median rank of genes in gene set: 7026
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
INPP4B 0.0095731 9 GTEx DepMap Descartes 2.73 433.56
CD9 0.0053778 42 GTEx DepMap Descartes 0.80 619.05
PDE3A 0.0036587 79 GTEx DepMap Descartes 1.26 235.81
STOM 0.0008462 680 GTEx DepMap Descartes 0.10 47.78
TGFB1 0.0006800 877 GTEx DepMap Descartes 0.21 106.86
PRKAR2B 0.0004085 1455 GTEx DepMap Descartes 0.42 150.45
ITGA2B 0.0003173 1792 GTEx DepMap Descartes 0.11 38.25
GP1BA 0.0002155 2358 GTEx DepMap Descartes 0.02 10.54
ACTN1 0.0001433 2937 GTEx DepMap Descartes 0.30 77.82
GSN 0.0001323 3016 GTEx DepMap Descartes 0.11 23.38
TRPC6 0.0000662 3705 GTEx DepMap Descartes 0.01 1.56
TUBB1 0.0000117 4443 GTEx DepMap Descartes 0.00 0.19
LIMS1 -0.0000010 4643 GTEx DepMap Descartes 0.24 69.28
MYLK -0.0000076 4769 GTEx DepMap Descartes 0.02 2.27
MMRN1 -0.0000151 4879 GTEx DepMap Descartes 0.02 3.73
ANGPT1 -0.0000558 5566 GTEx DepMap Descartes 0.02 6.50
UBASH3B -0.0000627 5693 GTEx DepMap Descartes 0.07 12.11
VCL -0.0000721 5870 GTEx DepMap Descartes 0.11 19.88
P2RX1 -0.0000897 6204 GTEx DepMap Descartes 0.00 2.60
TLN1 -0.0001003 6419 GTEx DepMap Descartes 0.08 11.48
ITGB3 -0.0001126 6675 GTEx DepMap Descartes 0.00 0.00
SLC24A3 -0.0001278 6972 GTEx DepMap Descartes 0.05 13.20
FERMT3 -0.0001299 7026 GTEx DepMap Descartes 0.01 7.07
ZYX -0.0001604 7596 GTEx DepMap Descartes 0.07 39.72
ARHGAP6 -0.0001738 7829 GTEx DepMap Descartes 0.01 1.57
RAP1B -0.0001861 8019 GTEx DepMap Descartes 0.17 14.82
LTBP1 -0.0002281 8690 GTEx DepMap Descartes 0.03 5.54
PSTPIP2 -0.0002432 8914 GTEx DepMap Descartes 0.00 0.66
CD84 -0.0002510 9028 GTEx DepMap Descartes 0.00 0.29
SPN -0.0002606 9171 GTEx DepMap Descartes 0.00 0.24


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 8044.36
Median rank of genes in gene set: 10192
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
NCALD 0.0047234 55 GTEx DepMap Descartes 0.93 333.47
RAP1GAP2 0.0019198 225 GTEx DepMap Descartes 1.82 361.23
SORL1 0.0018502 238 GTEx DepMap Descartes 0.52 64.13
CD44 0.0018213 241 GTEx DepMap Descartes 1.07 271.69
B2M 0.0014381 342 GTEx DepMap Descartes 1.48 932.16
ABLIM1 0.0009425 598 GTEx DepMap Descartes 0.35 60.15
MSN 0.0009196 616 GTEx DepMap Descartes 0.14 49.48
GNG2 0.0004555 1328 GTEx DepMap Descartes 0.64 226.45
LCP1 0.0003155 1798 GTEx DepMap Descartes 0.05 15.52
PITPNC1 0.0002736 2029 GTEx DepMap Descartes 0.91 182.64
ANKRD44 0.0000762 3592 GTEx DepMap Descartes 0.35 64.05
TMSB10 0.0000755 3603 GTEx DepMap Descartes 6.25 21728.09
CCND3 0.0000752 3606 GTEx DepMap Descartes 0.10 56.36
SAMD3 -0.0001522 7439 GTEx DepMap Descartes 0.01 3.23
LEF1 -0.0002151 8491 GTEx DepMap Descartes 0.02 4.96
CCL5 -0.0002363 8817 GTEx DepMap Descartes 0.00 0.31
MCTP2 -0.0002770 9386 GTEx DepMap Descartes 0.03 3.10
RCSD1 -0.0003094 9816 GTEx DepMap Descartes 0.01 2.30
ARHGDIB -0.0003097 9821 GTEx DepMap Descartes 0.01 17.98
ITPKB -0.0003347 10124 GTEx DepMap Descartes 0.01 2.04
SKAP1 -0.0003420 10187 GTEx DepMap Descartes 0.04 30.78
ARHGAP15 -0.0003430 10197 GTEx DepMap Descartes 0.11 45.77
ETS1 -0.0003525 10285 GTEx DepMap Descartes 0.03 5.34
PLEKHA2 -0.0004081 10780 GTEx DepMap Descartes 0.02 4.40
SP100 -0.0004100 10798 GTEx DepMap Descartes 0.04 9.57
FOXP1 -0.0004480 11078 GTEx DepMap Descartes 1.34 174.69
PRKCH -0.0004509 11100 GTEx DepMap Descartes 0.03 10.88
FYN -0.0004723 11252 GTEx DepMap Descartes 0.88 289.05
PTPRC -0.0004924 11363 GTEx DepMap Descartes 0.01 2.52
IKZF1 -0.0004963 11385 GTEx DepMap Descartes 0.00 0.21


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.78e-02
Mean rank of genes in gene set: 2871
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD44 0.0018213 241 GTEx DepMap Descartes 1.07 271.69
MALAT1 0.0010175 544 GTEx DepMap Descartes 217.93 33373.63
SATB1 0.0005312 1149 GTEx DepMap Descartes 0.20 37.39
TMSB10 0.0000755 3603 GTEx DepMap Descartes 6.25 21728.09
ITM2A -0.0002364 8818 GTEx DepMap Descartes 0.00 0.00


T cells: Tcm/Naive cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.90e-02
Mean rank of genes in gene set: 958.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
B2M 0.0014381 342 GTEx DepMap Descartes 1.48 932.16
CD8A 0.0003708 1575 GTEx DepMap Descartes 0.06 33.89


HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.08e-02
Mean rank of genes in gene set: 1055
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GATA2 0.0015257 318 GTEx DepMap Descartes 0.73 311.40
ITGA2B 0.0003173 1792 GTEx DepMap Descartes 0.11 38.25