Program: 18. Endothelial: Lymphatic.

Program: 18. Endothelial: Lymphatic.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 MMRN1 0.0220120 multimerin 1 GTEx DepMap Descartes 2.42 142.01
2 GNG11 0.0203177 G protein subunit gamma 11 GTEx DepMap Descartes 21.68 1614.62
3 TFPI 0.0202054 tissue factor pathway inhibitor GTEx DepMap Descartes 3.38 131.53
4 HSD17B2 0.0159589 hydroxysteroid 17-beta dehydrogenase 2 GTEx DepMap Descartes 0.28 9.62
5 PDPN 0.0146064 podoplanin GTEx DepMap Descartes 1.61 147.00
6 ANGPT2 0.0136742 angiopoietin 2 GTEx DepMap Descartes 4.00 195.97
7 FABP4 0.0136478 fatty acid binding protein 4 GTEx DepMap Descartes 20.04 5015.90
8 EDN1 0.0127857 endothelin 1 GTEx DepMap Descartes 1.36 190.49
9 TBX1 0.0127242 T-box transcription factor 1 GTEx DepMap Descartes 0.66 117.89
10 EFEMP1 0.0121508 EGF containing fibulin extracellular matrix protein 1 GTEx DepMap Descartes 3.35 298.36
11 TIE1 0.0119550 tyrosine kinase with immunoglobulin like and EGF like domains 1 GTEx DepMap Descartes 1.80 103.10
12 CLDN5 0.0119000 claudin 5 GTEx DepMap Descartes 9.36 919.28
13 FLT4 0.0118141 fms related receptor tyrosine kinase 4 GTEx DepMap Descartes 0.96 44.45
14 TMEM255B 0.0116528 transmembrane protein 255B GTEx DepMap Descartes 1.77 NA
15 PGM5 0.0115506 phosphoglucomutase 5 GTEx DepMap Descartes 0.26 20.91
16 STAB2 0.0114903 stabilin 2 GTEx DepMap Descartes 0.12 2.76
17 ABCA4 0.0112536 ATP binding cassette subfamily A member 4 GTEx DepMap Descartes 0.18 5.62
18 TFPI2 0.0096863 tissue factor pathway inhibitor 2 GTEx DepMap Descartes 1.15 125.14
19 TM4SF1 0.0096657 transmembrane 4 L six family member 1 GTEx DepMap Descartes 6.66 549.27
20 S100A16 0.0090924 S100 calcium binding protein A16 GTEx DepMap Descartes 4.42 823.86
21 EGFL7 0.0089522 EGF like domain multiple 7 GTEx DepMap Descartes 8.09 816.36
22 MYCT1 0.0089285 MYC target 1 GTEx DepMap Descartes 1.53 107.87
23 CDC42EP5 0.0087870 CDC42 effector protein 5 GTEx DepMap Descartes 1.46 493.94
24 RHOJ 0.0086689 ras homolog family member J GTEx DepMap Descartes 0.97 64.38
25 ACKR2 0.0085327 atypical chemokine receptor 2 GTEx DepMap Descartes 0.12 NA
26 PLSCR4 0.0084602 phospholipid scramblase 4 GTEx DepMap Descartes 0.54 48.73
27 PPFIBP1 0.0083478 PPFIA binding protein 1 GTEx DepMap Descartes 2.54 102.78
28 BMP6 0.0081673 bone morphogenetic protein 6 GTEx DepMap Descartes 0.18 9.10
29 ALDH1A1 0.0079974 aldehyde dehydrogenase 1 family member A1 GTEx DepMap Descartes 1.38 172.70
30 FILIP1 0.0076094 filamin A interacting protein 1 GTEx DepMap Descartes 1.53 43.29
31 KANK3 0.0075246 KN motif and ankyrin repeat domains 3 GTEx DepMap Descartes 1.03 85.75
32 ROBO4 0.0075007 roundabout guidance receptor 4 GTEx DepMap Descartes 2.05 111.71
33 ERG 0.0073760 ETS transcription factor ERG GTEx DepMap Descartes 1.08 NA
34 ART4 0.0073081 ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) GTEx DepMap Descartes 0.16 7.60
35 THBS1 0.0070537 thrombospondin 1 GTEx DepMap Descartes 2.42 79.15
36 RELN 0.0069887 reelin GTEx DepMap Descartes 0.42 12.35
37 GJA1 0.0069317 gap junction protein alpha 1 GTEx DepMap Descartes 1.69 112.25
38 AFAP1L1 0.0064791 actin filament associated protein 1 like 1 GTEx DepMap Descartes 0.89 34.41
39 MEDAG 0.0063643 mesenteric estrogen dependent adipogenesis GTEx DepMap Descartes 0.22 NA
40 CAV1 0.0063196 caveolin 1 GTEx DepMap Descartes 5.82 401.89
41 WWTR1 0.0059435 WW domain containing transcription regulator 1 GTEx DepMap Descartes 2.12 81.54
42 CALCRL 0.0059335 calcitonin receptor like receptor GTEx DepMap Descartes 1.80 73.40
43 LAMA4 0.0058328 laminin subunit alpha 4 GTEx DepMap Descartes 4.05 131.52
44 BMX 0.0057865 BMX non-receptor tyrosine kinase GTEx DepMap Descartes 0.26 25.17
45 FABP5 0.0056493 fatty acid binding protein 5 GTEx DepMap Descartes 20.31 4630.36
46 MGP 0.0054541 matrix Gla protein GTEx DepMap Descartes 23.28 3758.99
47 TGM2 0.0054255 transglutaminase 2 GTEx DepMap Descartes 1.51 54.54
48 CRIM1 0.0054172 cysteine rich transmembrane BMP regulator 1 GTEx DepMap Descartes 1.61 48.76
49 NTN4 0.0053220 netrin 4 GTEx DepMap Descartes 0.49 39.73
50 LMO2 0.0052502 LIM domain only 2 GTEx DepMap Descartes 1.64 170.01


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UMAP plots showing activity of gene expression program identified in GEP 18. Endothelial: Lymphatic:

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS 4.42e-22 56.37 28.60 4.94e-20 2.96e-19
17MMRN1, TFPI, TIE1, CLDN5, PGM5, STAB2, EGFL7, MYCT1, RHOJ, PPFIBP1, KANK3, ERG, RELN, CAV1, WWTR1, CALCRL, TGM2
 131
DESCARTES_MAIN_FETAL_LYMPHATIC_ENDOTHELIAL_CELLS 7.58e-18 60.02 28.07 5.09e-16 5.09e-15
13GNG11, TFPI, TBX1, TIE1, FLT4, TMEM255B, PGM5, STAB2, S100A16, RHOJ, PLSCR4, PPFIBP1, GJA1
 86
DESCARTES_FETAL_INTESTINE_LYMPHATIC_ENDOTHELIAL_CELLS 1.16e-10 65.43 23.04 3.70e-09 7.77e-08
7MMRN1, TFPI, TBX1, FLT4, STAB2, ABCA4, PLSCR4
 38
FAN_OVARY_CL16_LYMPHATIC_ENDOTHELIAL_CELL 4.65e-24 42.89 22.84 1.04e-21 3.12e-21
21MMRN1, GNG11, TFPI, PDPN, ANGPT2, FABP4, EFEMP1, TIE1, CLDN5, FLT4, TMEM255B, TM4SF1, S100A16, EGFL7, MYCT1, PPFIBP1, ALDH1A1, GJA1, CALCRL, LAMA4, FABP5
 232
AIZARANI_LIVER_C29_MVECS_2 5.30e-26 39.96 21.67 3.55e-23 3.55e-23
24MMRN1, GNG11, TFPI, EDN1, TIE1, CLDN5, PGM5, TFPI2, TM4SF1, S100A16, MYCT1, RHOJ, PLSCR4, FILIP1, ERG, GJA1, CAV1, WWTR1, CALCRL, BMX, MGP, TGM2, CRIM1, LMO2
 313
AIZARANI_LIVER_C9_LSECS_1 1.05e-24 37.92 20.48 3.53e-22 7.05e-22
23MMRN1, GNG11, TFPI, ANGPT2, EDN1, TIE1, FLT4, STAB2, TFPI2, TM4SF1, S100A16, EGFL7, MYCT1, RHOJ, PPFIBP1, FILIP1, ROBO4, ERG, RELN, WWTR1, TGM2, CRIM1, NTN4
 304
AIZARANI_LIVER_C13_LSECS_2 8.12e-24 37.63 20.23 1.36e-21 5.45e-21
22GNG11, TFPI, EDN1, TIE1, CLDN5, FLT4, TMEM255B, PGM5, STAB2, TFPI2, TM4SF1, S100A16, EGFL7, MYCT1, PPFIBP1, FILIP1, ROBO4, ERG, RELN, CALCRL, TGM2, NTN4
 283
AIZARANI_LIVER_C10_MVECS_1 1.03e-22 36.50 19.50 1.38e-20 6.91e-20
21MMRN1, GNG11, EDN1, TIE1, CLDN5, PGM5, TM4SF1, EGFL7, MYCT1, RHOJ, FILIP1, ROBO4, ERG, GJA1, CAV1, WWTR1, CALCRL, MGP, TGM2, CRIM1, LMO2
 269
GAO_LARGE_INTESTINE_24W_C2_MKI67POS_PROGENITOR 1.28e-14 39.06 18.03 5.38e-13 8.61e-12
12MMRN1, GNG11, TFPI, FABP4, TIE1, CLDN5, TM4SF1, EGFL7, MYCT1, ROBO4, ERG, CALCRL
 113
CUI_DEVELOPING_HEART_C4_ENDOTHELIAL_CELL 2.47e-16 36.80 17.90 1.38e-14 1.66e-13
14MMRN1, GNG11, TFPI, TIE1, TM4SF1, S100A16, EGFL7, MYCT1, ROBO4, AFAP1L1, WWTR1, CALCRL, BMX, TGM2
 146
TRAVAGLINI_LUNG_LYMPHATIC_CELL 1.40e-18 33.52 17.20 1.17e-16 9.40e-16
17MMRN1, PDPN, ANGPT2, FABP4, TBX1, EFEMP1, FLT4, PGM5, STAB2, RHOJ, ACKR2, PPFIBP1, FILIP1, RELN, MEDAG, LAMA4, FABP5
 209
CUI_DEVELOPING_HEART_CORONARY_VASCULAR_ENDOTHELIAL_CELL 1.16e-08 48.57 15.89 2.89e-07 7.81e-06
6FABP4, CLDN5, FLT4, ROBO4, CAV1, FABP5
 41
DESCARTES_FETAL_EYE_VASCULAR_ENDOTHELIAL_CELLS 6.17e-11 33.83 13.99 2.07e-09 4.14e-08
9TIE1, CLDN5, FLT4, EGFL7, MYCT1, KANK3, ROBO4, ERG, CALCRL
 90
FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_1 4.05e-21 25.55 13.87 3.89e-19 2.72e-18
23GNG11, ANGPT2, EDN1, TIE1, CLDN5, FLT4, TM4SF1, S100A16, EGFL7, MYCT1, RHOJ, PPFIBP1, KANK3, ROBO4, ERG, GJA1, AFAP1L1, CAV1, WWTR1, CALCRL, LAMA4, TGM2, LMO2
 440
DESCARTES_FETAL_PANCREAS_LYMPHATIC_ENDOTHELIAL_CELLS 5.81e-09 35.05 12.76 1.56e-07 3.90e-06
7MMRN1, TFPI, TBX1, PGM5, STAB2, ABCA4, BMP6
 65
AIZARANI_LIVER_C20_LSECS_3 9.75e-15 21.09 10.74 4.67e-13 6.54e-12
16TFPI, TIE1, STAB2, TFPI2, TM4SF1, S100A16, MYCT1, RHOJ, PPFIBP1, FILIP1, ROBO4, ERG, RELN, WWTR1, TGM2, CRIM1
 295
DESCARTES_FETAL_ADRENAL_VASCULAR_ENDOTHELIAL_CELLS 1.27e-10 24.19 10.57 3.88e-09 8.53e-08
10EDN1, TIE1, CLDN5, FLT4, TMEM255B, STAB2, KANK3, ROBO4, AFAP1L1, CALCRL
 139
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_PERICYTES 2.30e-08 28.24 10.37 5.52e-07 1.54e-05
7GNG11, EDN1, CLDN5, TM4SF1, EGFL7, CAV1, CALCRL
 79
MURARO_PANCREAS_ENDOTHELIAL_CELL 1.19e-14 18.67 9.66 5.34e-13 8.01e-12
17GNG11, ANGPT2, TIE1, FLT4, TM4SF1, MYCT1, RHOJ, ROBO4, ERG, THBS1, AFAP1L1, CAV1, WWTR1, CALCRL, LAMA4, FABP5, LMO2
 362
FAN_OVARY_CL9_PUTATIVE_APOPTOTIC_ENDOTHELIAL_CELL 1.36e-14 18.51 9.57 5.38e-13 9.15e-12
17GNG11, TFPI, ANGPT2, CLDN5, TMEM255B, TM4SF1, S100A16, MYCT1, PPFIBP1, ERG, THBS1, CAV1, WWTR1, CALCRL, LAMA4, MGP, CRIM1
 365

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 1.08e-03 7.12 2.18 5.40e-02 5.40e-02
5TFPI2, THBS1, GJA1, MGP, TGM2
 200
HALLMARK_UV_RESPONSE_DN 2.44e-03 7.76 2.00 6.10e-02 1.22e-01
4TFPI, EFEMP1, GJA1, CAV1
 144
HALLMARK_KRAS_SIGNALING_UP 7.71e-03 5.55 1.44 1.22e-01 3.85e-01
4GNG11, TFPI, FLT4, RELN
 200
HALLMARK_BILE_ACID_METABOLISM 9.77e-03 7.32 1.44 1.22e-01 4.88e-01
3ABCA4, BMP6, ALDH1A1
 112
HALLMARK_TGF_BETA_SIGNALING 1.94e-02 10.01 1.15 1.94e-01 9.68e-01
2THBS1, WWTR1
 54
HALLMARK_ESTROGEN_RESPONSE_LATE 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3TFPI2, CAV1, FABP5
 200
HALLMARK_INFLAMMATORY_RESPONSE 4.35e-02 4.05 0.80 3.11e-01 1.00e+00
3PDPN, EDN1, CALCRL
 200
HALLMARK_COAGULATION 1.03e-01 3.83 0.45 6.42e-01 1.00e+00
2TFPI2, THBS1
 138
HALLMARK_HYPOXIA 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2CAV1, TGM2
 200
HALLMARK_ADIPOGENESIS 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2FABP4, LAMA4
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.85e-01 2.63 0.31 7.70e-01 1.00e+00
2GJA1, TGM2
 200
HALLMARK_PANCREAS_BETA_CELLS 1.47e-01 6.54 0.16 7.70e-01 1.00e+00
1LMO2
 40
HALLMARK_CHOLESTEROL_HOMEOSTASIS 2.55e-01 3.49 0.09 9.81e-01 1.00e+00
1FABP5
 74
HALLMARK_PEROXISOME 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1ALDH1A1
 104
HALLMARK_FATTY_ACID_METABOLISM 4.66e-01 1.62 0.04 1.00e+00 1.00e+00
1ALDH1A1
 158
HALLMARK_APOPTOSIS 4.72e-01 1.59 0.04 1.00e+00 1.00e+00
1CAV1
 161
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1TGM2
 199
HALLMARK_TNFA_SIGNALING_VIA_NFKB 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1EDN1
 200
HALLMARK_MYOGENESIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1WWTR1
 200
HALLMARK_APICAL_JUNCTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1CLDN5
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_FOCAL_ADHESION 1.06e-03 7.16 2.19 1.96e-01 1.96e-01
5FLT4, THBS1, RELN, CAV1, LAMA4
 199
KEGG_ECM_RECEPTOR_INTERACTION 4.44e-03 9.85 1.92 4.13e-01 8.25e-01
3THBS1, RELN, LAMA4
 84
KEGG_PPAR_SIGNALING_PATHWAY 3.05e-02 7.77 0.90 1.00e+00 1.00e+00
2FABP4, FABP5
 69
KEGG_TGF_BETA_SIGNALING_PATHWAY 4.54e-02 6.20 0.72 1.00e+00 1.00e+00
2BMP6, THBS1
 86
KEGG_BLADDER_CANCER 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1THBS1
 42
KEGG_ABC_TRANSPORTERS 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1ABCA4
 44
KEGG_STEROID_HORMONE_BIOSYNTHESIS 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1HSD17B2
 55
KEGG_HEDGEHOG_SIGNALING_PATHWAY 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1BMP6
 56
KEGG_RETINOL_METABOLISM 2.25e-01 4.05 0.10 1.00e+00 1.00e+00
1ALDH1A1
 64
KEGG_P53_SIGNALING_PATHWAY 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1THBS1
 68
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 2.40e-01 3.75 0.09 1.00e+00 1.00e+00
1TFPI
 69
KEGG_VIRAL_MYOCARDITIS 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1CAV1
 70
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1GJA1
 74
KEGG_SMALL_CELL_LUNG_CANCER 2.84e-01 3.07 0.08 1.00e+00 1.00e+00
1LAMA4
 84
KEGG_GAP_JUNCTION 3.01e-01 2.87 0.07 1.00e+00 1.00e+00
1GJA1
 90
KEGG_MELANOGENESIS 3.31e-01 2.55 0.06 1.00e+00 1.00e+00
1EDN1
 101
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 3.67e-01 2.24 0.06 1.00e+00 1.00e+00
1CALCRL
 115
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 3.69e-01 2.22 0.05 1.00e+00 1.00e+00
1CLDN5
 116
KEGG_AXON_GUIDANCE 4.01e-01 1.99 0.05 1.00e+00 1.00e+00
1NTN4
 129
KEGG_TIGHT_JUNCTION 4.08e-01 1.95 0.05 1.00e+00 1.00e+00
1CLDN5
 132

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr6p24 2.14e-02 9.46 1.09 1.00e+00 1.00e+00
2EDN1, BMP6
 57
chr12p12 6.67e-02 4.96 0.58 1.00e+00 1.00e+00
2ART4, MGP
 107
chr2q32 6.78e-02 4.91 0.57 1.00e+00 1.00e+00
2TFPI, CALCRL
 108
chr3q25 1.20e-01 3.47 0.41 1.00e+00 1.00e+00
2TM4SF1, WWTR1
 152
chr7q21 1.36e-01 3.21 0.38 1.00e+00 1.00e+00
2GNG11, TFPI2
 164
chr8q21 1.55e-01 2.96 0.35 1.00e+00 1.00e+00
2FABP4, FABP5
 178
chr9q21 1.68e-01 2.80 0.33 1.00e+00 1.00e+00
2PGM5, ALDH1A1
 188
chr22q11 6.61e-01 1.36 0.16 1.00e+00 1.00e+00
2TBX1, CLDN5
 384
chr12q22 1.84e-01 5.10 0.12 1.00e+00 1.00e+00
1NTN4
 51
chr15q14 2.00e-01 4.64 0.11 1.00e+00 1.00e+00
1THBS1
 56
chr4q22 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1MMRN1
 70
chr12p11 2.64e-01 3.36 0.08 1.00e+00 1.00e+00
1PPFIBP1
 77
chr6q14 3.09e-01 2.77 0.07 1.00e+00 1.00e+00
1FILIP1
 93
chr2p22 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1CRIM1
 98
chr16q23 3.39e-01 2.48 0.06 1.00e+00 1.00e+00
1HSD17B2
 104
chr2p16 3.64e-01 2.26 0.06 1.00e+00 1.00e+00
1EFEMP1
 114
chr6q21 3.72e-01 2.20 0.05 1.00e+00 1.00e+00
1LAMA4
 117
chr6q22 3.77e-01 2.16 0.05 1.00e+00 1.00e+00
1GJA1
 119
chr14q23 3.89e-01 2.07 0.05 1.00e+00 1.00e+00
1RHOJ
 124
chr1p22 4.01e-01 1.99 0.05 1.00e+00 1.00e+00
1ABCA4
 129

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GATA1_05 1.07e-04 7.35 2.76 1.21e-01 1.21e-01
7ANGPT2, EGFL7, MYCT1, ALDH1A1, FILIP1, ERG, LMO2
 284
GATA_Q6 1.10e-03 7.08 2.17 1.88e-01 1.00e+00
5EDN1, MYCT1, BMP6, ERG, LMO2
 201
GATAAGR_GATA_C 1.01e-03 5.82 2.01 1.88e-01 1.00e+00
6ANGPT2, EDN1, MYCT1, BMP6, ERG, LMO2
 299
GATA3_01 2.60e-03 5.79 1.78 2.94e-01 1.00e+00
5EDN1, EFEMP1, BMP6, FILIP1, ERG
 245
RYTTCCTG_ETS2_B 5.29e-04 3.59 1.70 1.88e-01 6.00e-01
12MMRN1, GNG11, ANGPT2, CLDN5, EGFL7, MYCT1, RHOJ, FILIP1, ROBO4, ERG, CALCRL, BMX
 1112
GATA_C 3.79e-03 5.28 1.62 3.57e-01 1.00e+00
5ANGPT2, EDN1, MYCT1, BMP6, LMO2
 268
FOXJ2_02 1.48e-02 4.55 1.18 6.67e-01 1.00e+00
4EDN1, EFEMP1, ERG, CRIM1
 243
EVI1_02 1.67e-02 5.95 1.17 6.67e-01 1.00e+00
3S100A16, MYCT1, LMO2
 137
NKX62_Q2 1.54e-02 4.49 1.17 6.67e-01 1.00e+00
4FABP4, FILIP1, ERG, BMX
 246
STAT6_02 1.84e-02 4.25 1.10 6.67e-01 1.00e+00
4EDN1, EGFL7, RHOJ, ERG
 260
EVI1_03 2.21e-02 9.30 1.07 6.77e-01 1.00e+00
2MYCT1, LMO2
 58
GATA6_01 2.03e-02 4.12 1.07 6.67e-01 1.00e+00
4ANGPT2, MYCT1, BMP6, ERG
 268
CEBP_Q2_01 2.13e-02 4.06 1.05 6.69e-01 1.00e+00
4EFEMP1, ERG, BMX, CRIM1
 272
EVI1_05 3.08e-02 4.67 0.92 8.24e-01 1.00e+00
3MYCT1, NTN4, LMO2
 174
AACTTT_UNKNOWN 9.09e-02 1.84 0.85 9.43e-01 1.00e+00
11PDPN, ANGPT2, FABP4, ALDH1A1, FILIP1, ERG, THBS1, RELN, GJA1, LAMA4, CRIM1
 1928
GR_01 4.51e-02 3.99 0.79 9.14e-01 1.00e+00
3TIE1, FILIP1, CALCRL
 203
CATTGTYY_SOX9_B1 5.35e-02 2.99 0.78 9.14e-01 1.00e+00
4GNG11, EDN1, MYCT1, ERG
 368
FOX_Q2 5.07e-02 3.80 0.75 9.14e-01 1.00e+00
3FABP4, EFEMP1, CRIM1
 213
WGGAATGY_TEF1_Q6 6.19e-02 2.84 0.74 9.14e-01 1.00e+00
4EDN1, PPFIBP1, ERG, CAV1
 387
E4BP4_01 5.65e-02 3.63 0.72 9.14e-01 1.00e+00
3ALDH1A1, CALCRL, CRIM1
 223

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_LYMPH_VESSEL_DEVELOPMENT 3.10e-06 49.25 11.88 3.86e-03 2.32e-02
4PDPN, TBX1, TIE1, FLT4
 26
GOBP_LYMPHANGIOGENESIS 3.88e-05 56.82 10.14 2.07e-02 2.90e-01
3PDPN, TIE1, FLT4
 17
GOBP_LYMPHATIC_ENDOTHELIAL_CELL_DIFFERENTIATION 4.28e-04 86.37 8.33 1.04e-01 1.00e+00
2PDPN, TIE1
 8
GOBP_LYMPH_VESSEL_MORPHOGENESIS 7.49e-05 44.24 8.07 3.05e-02 5.60e-01
3PDPN, TIE1, FLT4
 21
GOBP_GAP_JUNCTION_ASSEMBLY 1.18e-03 47.19 4.96 1.92e-01 1.00e+00
2GJA1, CAV1
 13
GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION 3.67e-05 15.25 4.62 2.07e-02 2.75e-01
5EDN1, THBS1, GJA1, CALCRL, TGM2
 96
GOBP_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING 1.37e-03 43.30 4.59 2.15e-01 1.00e+00
2GJA1, CAV1
 14
GOBP_ENDOTHELIUM_DEVELOPMENT 1.53e-05 13.01 4.45 1.14e-02 1.14e-01
6PDPN, TIE1, CLDN5, BMP6, ROBO4, GJA1
 137
GOBP_RESPONSE_TO_RETINOIC_ACID 5.14e-05 14.17 4.30 2.32e-02 3.84e-01
5HSD17B2, TBX1, TIE1, BMP6, GJA1
 103
GOBP_ENDOTHELIAL_CELL_PROLIFERATION 8.83e-06 11.06 4.14 7.34e-03 6.61e-02
7TIE1, FLT4, EGFL7, BMP6, THBS1, GJA1, CAV1
 191
GOBP_REGULATION_OF_COAGULATION 1.74e-04 16.21 4.12 5.92e-02 1.00e+00
4TFPI, EDN1, THBS1, CAV1
 71
GOBP_ADAPTIVE_THERMOGENESIS 2.84e-05 11.59 3.97 1.77e-02 2.13e-01
6FABP4, ALDH1A1, GJA1, CAV1, LAMA4, FABP5
 153
GOBP_NEGATIVE_REGULATION_OF_WOUND_HEALING 2.04e-04 15.52 3.95 6.50e-02 1.00e+00
4TFPI, EDN1, THBS1, GJA1
 74
GOBP_MIDDLE_EAR_MORPHOGENESIS 2.03e-03 34.68 3.75 2.53e-01 1.00e+00
2EDN1, TBX1
 17
GOBP_TEMPERATURE_HOMEOSTASIS 5.26e-05 10.32 3.55 2.32e-02 3.94e-01
6FABP4, ALDH1A1, GJA1, CAV1, LAMA4, FABP5
 171
GOBP_RESPONSE_TO_MAGNESIUM_ION 2.28e-03 32.49 3.53 2.71e-01 1.00e+00
2BMP6, THBS1
 18
GOBP_REGULATION_OF_WOUND_HEALING 1.59e-04 11.02 3.36 5.67e-02 1.00e+00
5TFPI, EDN1, THBS1, GJA1, CAV1
 131
GOBP_CHRONIC_INFLAMMATORY_RESPONSE 2.54e-03 30.58 3.34 2.81e-01 1.00e+00
2THBS1, GJA1
 19
GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING 4.31e-04 12.63 3.23 1.04e-01 1.00e+00
4TFPI, EDN1, THBS1, GJA1
 90
GOBP_BLOOD_VESSEL_MORPHOGENESIS 9.04e-07 6.62 3.21 1.35e-03 6.76e-03
13ANGPT2, EDN1, TBX1, TIE1, CLDN5, FLT4, STAB2, EGFL7, RHOJ, ROBO4, THBS1, CAV1, CALCRL
 677

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP 9.76e-06 10.88 4.08 2.63e-02 4.76e-02
7MYCT1, PLSCR4, PPFIBP1, ALDH1A1, ROBO4, ERG, WWTR1
 194
GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_30MIN_UP 1.08e-05 10.71 4.01 2.63e-02 5.25e-02
7MMRN1, TFPI, MYCT1, PLSCR4, ALDH1A1, ROBO4, CALCRL
 197
GSE7548_DAY7_VS_DAY28_PCC_IMMUNIZATION_CD4_TCELL_UP 1.24e-04 8.78 3.02 1.21e-01 6.03e-01
6TFPI, FABP4, PPFIBP1, BMP6, KANK3, THBS1
 200
GSE21670_STAT3_KO_VS_WT_CD4_TCELL_IL6_TREATED_DN 1.24e-04 8.78 3.02 1.21e-01 6.03e-01
6MMRN1, GNG11, TIE1, MYCT1, PLSCR4, TGM2
 200
GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_UP 1.24e-04 8.78 3.02 1.21e-01 6.03e-01
6GNG11, TFPI, TIE1, TM4SF1, RHOJ, KANK3
 200
GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_DN 5.24e-04 8.42 2.57 4.25e-01 1.00e+00
5TIE1, STAB2, GJA1, AFAP1L1, CALCRL
 170
GSE8621_UNSTIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_UP 1.06e-03 7.16 2.19 4.38e-01 1.00e+00
5MYCT1, ALDH1A1, GJA1, TGM2, CRIM1
 199
GSE28783_ANTI_MIR33_VS_UNTREATED_ATHEROSCLEROSIS_MACROPHAGE_UP 1.06e-03 7.16 2.19 4.38e-01 1.00e+00
5TFPI, TFPI2, ALDH1A1, RELN, LMO2
 199
GSE8621_LPS_STIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_UP 1.08e-03 7.12 2.18 4.38e-01 1.00e+00
5FABP4, RHOJ, GJA1, MEDAG, NTN4
 200
GSE19198_CTRL_VS_IL21_TREATED_TCELL_24H_UP 1.08e-03 7.12 2.18 4.38e-01 1.00e+00
5ANGPT2, EDN1, TFPI2, RHOJ, TGM2
 200
GSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_DN 1.08e-03 7.12 2.18 4.38e-01 1.00e+00
5MMRN1, GNG11, ERG, CRIM1, LMO2
 200
GSE43955_10H_VS_60H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN 1.08e-03 7.12 2.18 4.38e-01 1.00e+00
5HSD17B2, EDN1, TFPI2, WWTR1, MGP
 200
GSE7509_UNSTIM_VS_FCGRIIB_STIM_DC_UP 4.67e-03 6.43 1.66 8.35e-01 1.00e+00
4CLDN5, CDC42EP5, RHOJ, MGP
 173
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN 4.96e-03 6.32 1.63 8.35e-01 1.00e+00
4GNG11, TM4SF1, THBS1, MGP
 176
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_UP 5.90e-03 6.00 1.55 8.35e-01 1.00e+00
4ANGPT2, EDN1, TM4SF1, THBS1
 185
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP 6.12e-03 5.94 1.54 8.35e-01 1.00e+00
4FLT4, S100A16, RHOJ, WWTR1
 187
GSE11864_CSF1_PAM3CYS_VS_CSF1_IFNG_PAM3CYS_IN_MAC_UP 7.07e-03 5.69 1.47 8.35e-01 1.00e+00
4PDPN, TMEM255B, PPFIBP1, BMP6
 195
GSE16385_ROSIGLITAZONE_IL4_VS_IFNG_TNF_STIM_MACROPHAGE_DN 7.07e-03 5.69 1.47 8.35e-01 1.00e+00
4EFEMP1, ALDH1A1, GJA1, CAV1
 195
GSE24814_STAT5_KO_VS_WT_PRE_BCELL_UP 7.32e-03 5.63 1.46 8.35e-01 1.00e+00
4PDPN, LAMA4, TGM2, LMO2
 197
GSE14769_UNSTIM_VS_80MIN_LPS_BMDM_DN 7.58e-03 5.57 1.44 8.35e-01 1.00e+00
4FABP4, GJA1, CAV1, TGM2
 199

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
EDN1 8 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein that is processed into a secreted signaling peptide
TBX1 9 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ERG 33 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RELN 36 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a large secreted extracellular matrix protein
WWTR1 41 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Transcriptional co-activator that binds to TEADs (PMID: 19324877) and TBX5 (PMID: 16332960)
LMO2 50 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Protein binds to bHLH TFs, which then bind to DNA (PMID: 9707419). Both transfac motifs are suspect - the bHLH motif likely resulted from an indirect interaction.
SPHK1 57 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ELK3 65 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HES1 95 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PROX1 99 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
BCL6B 101 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NR2F2 104 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
NFIA 108 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
HOXA7 137 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TAL1 144 Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain No motif yielded from PBMs or HT-SELEX. Binds DNA as heterodimer with TCF3 (PDB:2YPB and PDB:2YPA).
YBX3 146 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Identical DBD to YBX1. Might also bind RNA.
PREX2 151 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SP6 155 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
ID3 172 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
FZD4 178 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T200_TATCGCCAGCTCCGAC-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 1429.73
Raw ScoresEndothelial_cells:lymphatic: 0.43, Endothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic:KSHV: 0.38, Endothelial_cells:blood_vessel: 0.38, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:FPV-infected: 0.37, Endothelial_cells:HUVEC: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:HUVEC:H5N1-infected: 0.36
T200_GAGATGGGTATGGAAT-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 1257.91
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.44, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.4, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC: 0.38
T200_AAGAACAAGGTATCTC-1 Endothelial_cells:lymphatic:TNFa_48h 0.16 1179.54
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:HUVEC:FPV-infected: 0.33, Endothelial_cells:HUVEC:PR8-infected: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.32, Endothelial_cells:HUVEC:IFNg: 0.32, Endothelial_cells:blood_vessel: 0.32, Endothelial_cells:lymphatic:KSHV: 0.32, Endothelial_cells:HUVEC: 0.32
T200_GAATCGTCACAACATC-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 1146.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.45, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC: 0.4
T200_TTTGGAGGTAAGTCAA-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 1145.66
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.39, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39, Endothelial_cells:HUVEC: 0.38
T200_TGTGAGTCAGAGACTG-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 1144.54
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.35, Endothelial_cells:blood_vessel: 0.35, Endothelial_cells:lymphatic:KSHV: 0.35, Endothelial_cells:HUVEC:PR8-infected: 0.35, Endothelial_cells:HUVEC:B._anthracis_LT: 0.35, Endothelial_cells:HUVEC:H5N1-infected: 0.35, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.35, Endothelial_cells:HUVEC: 0.34
T200_TGTTCATTCACGACTA-1 Endothelial_cells:lymphatic:TNFa_48h 0.18 1140.79
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.38, Endothelial_cells:HUVEC:PR8-infected: 0.38, Endothelial_cells:HUVEC:H5N1-infected: 0.37, Endothelial_cells:lymphatic:KSHV: 0.36, Endothelial_cells:blood_vessel: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC: 0.36, Endothelial_cells:HUVEC:IFNg: 0.36
T200_CGAAGGAGTGCATTAC-1 Endothelial_cells:lymphatic:TNFa_48h 0.19 934.47
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:KSHV: 0.39, Endothelial_cells:HUVEC:FPV-infected: 0.38, Endothelial_cells:HUVEC:PR8-infected: 0.38, Endothelial_cells:blood_vessel: 0.38, Endothelial_cells:HUVEC:H5N1-infected: 0.37, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.36, Endothelial_cells:HUVEC:IFNg: 0.36
T200_GGCGTCATCAGGAGAC-1 Endothelial_cells:lymphatic 0.17 856.99
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.45, Endothelial_cells:lymphatic: 0.44, Endothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC: 0.39
T230_TGTTGAGCAAATGATG-1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.15 751.98
Raw ScoresEndothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:HUVEC:IFNg: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.41
T200_CGCCAGATCATAGACC-1 Endothelial_cells:lymphatic:TNFa_48h 0.16 632.25
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:lymphatic: 0.39, Endothelial_cells:HUVEC:FPV-infected: 0.38, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:lymphatic:KSHV: 0.36, Endothelial_cells:HUVEC:H5N1-infected: 0.36, Endothelial_cells:HUVEC:IFNg: 0.36, Endothelial_cells:blood_vessel: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.36
T214_GGGCTACTCACATACG-1 Neurons:adrenal_medulla_cell_line 0.10 608.02
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.36, Endothelial_cells:lymphatic: 0.35, Endothelial_cells:lymphatic:KSHV: 0.33, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.33, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:HUVEC:FPV-infected: 0.32, Endothelial_cells:HUVEC: 0.32, Endothelial_cells:HUVEC:IL-1b: 0.32, Endothelial_cells:HUVEC:B._anthracis_LT: 0.32, Endothelial_cells:HUVEC:PR8-infected: 0.32
T200_ACAAGCTGTAGGTCAG-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 580.91
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.46, Endothelial_cells:lymphatic: 0.45, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.41, Endothelial_cells:HUVEC:IL-1b: 0.41
T19_GGACGTCCACGGATAG.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 579.35
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:lymphatic: 0.37, Endothelial_cells:blood_vessel: 0.34, Endothelial_cells:lymphatic:KSHV: 0.34, Endothelial_cells:HUVEC:PR8-infected: 0.34, Endothelial_cells:HUVEC:FPV-infected: 0.34, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.33
T200_AAGACTCTCTCTCTAA-1 Endothelial_cells:lymphatic:TNFa_48h 0.17 518.30
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:HUVEC:PR8-infected: 0.38, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC:FPV-infected: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:IL-1b: 0.37, Endothelial_cells:HUVEC: 0.37
T175_CCACACTCAGCGTGCT-1 Endothelial_cells:lymphatic 0.15 515.28
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.34, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:lymphatic:KSHV: 0.31, Endothelial_cells:blood_vessel: 0.31, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.3, Endothelial_cells:HUVEC:FPV-infected: 0.3, Endothelial_cells:HUVEC:B._anthracis_LT: 0.3, Endothelial_cells:HUVEC: 0.3, Endothelial_cells:HUVEC:VEGF: 0.3, Endothelial_cells:HUVEC:PR8-infected: 0.29
T19_AGGTCATAGGCATGGT.1 Endothelial_cells:lymphatic 0.10 487.90
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.31, Endothelial_cells:lymphatic: 0.31, Endothelial_cells:HUVEC:IFNg: 0.29, Endothelial_cells:blood_vessel: 0.29, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.29, Endothelial_cells:lymphatic:KSHV: 0.29, Endothelial_cells:HUVEC:PR8-infected: 0.28, Endothelial_cells:HUVEC: 0.28, Endothelial_cells:HUVEC:FPV-infected: 0.28, Endothelial_cells:HUVEC:H5N1-infected: 0.28
T200_GAAATGATCATTCACT-1 Endothelial_cells:lymphatic:TNFa_48h 0.16 472.60
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39, Endothelial_cells:HUVEC: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.39, Endothelial_cells:HUVEC:IL-1b: 0.39
T200_ACTGTGAGTGCTGTCG-1 Endothelial_cells:blood_vessel 0.20 449.91
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC: 0.39
T200_GTGTCCTGTGGTCTAT-1 Endothelial_cells:lymphatic:TNFa_48h 0.18 430.33
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:KSHV: 0.41, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:HUVEC:PR8-infected: 0.39, Endothelial_cells:HUVEC:B._anthracis_LT: 0.38, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC:H5N1-infected: 0.38, Endothelial_cells:HUVEC: 0.38
T200_GGGTCTGGTCCCTGAG-1 Endothelial_cells:lymphatic:TNFa_48h 0.19 428.26
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.44, Endothelial_cells:HUVEC:IFNg: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.39
T200_GTGTCCTGTTAGCTAC-1 Endothelial_cells:lymphatic:TNFa_48h 0.20 415.75
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:HUVEC:IFNg: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:blood_vessel: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4
T230_AGGTTGTCACCTCTGT-1 Endothelial_cells:HUVEC:IFNg 0.20 365.32
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.44, Endothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:HUVEC: 0.39
T19_GGGTTGCTCTTAGCCC.1 Endothelial_cells:lymphatic:TNFa_48h 0.11 353.95
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.32, Endothelial_cells:lymphatic: 0.31, Endothelial_cells:HUVEC:IFNg: 0.29, Endothelial_cells:blood_vessel: 0.29, Endothelial_cells:lymphatic:KSHV: 0.29, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.29, Endothelial_cells:HUVEC:FPV-infected: 0.29, Endothelial_cells:HUVEC:PR8-infected: 0.28, Endothelial_cells:HUVEC:B._anthracis_LT: 0.28, Endothelial_cells:HUVEC: 0.28
T230_ATCCGTCGTAACAGGC-1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.18 299.10
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.43, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.42, Endothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:HUVEC:VEGF: 0.42, Endothelial_cells:HUVEC: 0.42, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.41, Endothelial_cells:HUVEC:H5N1-infected: 0.41, Endothelial_cells:HUVEC:FPV-infected: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41
T200_TTCTCTCTCTCCGATC-1 Endothelial_cells:blood_vessel 0.19 222.00
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.44, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:blood_vessel: 0.43, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:HUVEC:PR8-infected: 0.41, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:FPV-infected: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.4, Endothelial_cells:HUVEC: 0.4
T200_GGTGAAGCAACAGCCC-1 Endothelial_cells:blood_vessel 0.17 180.15
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.39, Endothelial_cells:lymphatic:KSHV: 0.39, Endothelial_cells:blood_vessel: 0.38, Endothelial_cells:lymphatic: 0.38, Endothelial_cells:HUVEC:FPV-infected: 0.37, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.37, Endothelial_cells:HUVEC: 0.36, Endothelial_cells:HUVEC:H5N1-infected: 0.36
T200_CATCCCAGTGCCGAAA-1 Endothelial_cells:HUVEC:FPV-infected 0.12 165.28
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.37, Endothelial_cells:blood_vessel: 0.37, Endothelial_cells:lymphatic:KSHV: 0.37, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.36, Endothelial_cells:lymphatic: 0.36, Endothelial_cells:HUVEC:FPV-infected: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.35, Endothelial_cells:HUVEC: 0.35, Endothelial_cells:HUVEC:H5N1-infected: 0.35
T69_AGCCTAAAGGAATCGC.1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.13 164.05
Raw ScoresEndothelial_cells:HUVEC:H5N1-infected: 0.35, Endothelial_cells:HUVEC:IFNg: 0.35, Endothelial_cells:HUVEC:PR8-infected: 0.35, Endothelial_cells:HUVEC:FPV-infected: 0.35, Endothelial_cells:HUVEC: 0.35, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.35, Endothelial_cells:lymphatic:TNFa_48h: 0.34, Endothelial_cells:HUVEC:VEGF: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.34, Endothelial_cells:lymphatic: 0.34
T200_AGTTAGCGTGCAATGG-1 Endothelial_cells:lymphatic:TNFa_48h 0.19 155.04
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.43, Endothelial_cells:blood_vessel: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:HUVEC:B._anthracis_LT: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:IFNg: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.4, Endothelial_cells:HUVEC:H5N1-infected: 0.39
T200_CAACCAAGTAGACACG-1 Endothelial_cells:lymphatic:TNFa_48h 0.13 154.68
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.41, Endothelial_cells:HUVEC:IFNg: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:lymphatic:KSHV: 0.4, Endothelial_cells:HUVEC:PR8-infected: 0.39, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.39, Endothelial_cells:HUVEC:B._anthracis_LT: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC: 0.38
T19_GAAACTCGTCAACTGT.1 Endothelial_cells:blood_vessel 0.10 150.58
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:blood_vessel: 0.32, Endothelial_cells:HUVEC:IFNg: 0.31, Endothelial_cells:HUVEC:FPV-infected: 0.31, Endothelial_cells:lymphatic:KSHV: 0.31, Endothelial_cells:HUVEC:B._anthracis_LT: 0.31, Endothelial_cells:HUVEC:PR8-infected: 0.31, Endothelial_cells:HUVEC: 0.31, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.3
T69_CAGATCACAGTATCTG.1 Neutrophil:commensal_E._coli_MG1655 0.08 133.47
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.31, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.31, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.3, Monocyte:CD16-: 0.3, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.3, Monocyte:anti-FcgRIIB: 0.3, Monocyte:CD14+: 0.29, Monocyte: 0.29, Monocyte:leukotriene_D4: 0.29, DC:monocyte-derived:antiCD40/VAF347: 0.29
T200_TGTGATGTCCAGTGTA-1 Endothelial_cells:HUVEC:IFNg 0.12 128.45
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:HUVEC:B._anthracis_LT: 0.32, Endothelial_cells:lymphatic:TNFa_48h: 0.32, Endothelial_cells:HUVEC:PR8-infected: 0.32, Endothelial_cells:HUVEC:FPV-infected: 0.32, Endothelial_cells:lymphatic: 0.32, Endothelial_cells:HUVEC:H5N1-infected: 0.32, Endothelial_cells:HUVEC: 0.31, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.31, Endothelial_cells:blood_vessel: 0.31
T200_CAATTTCGTATGAGAT-1 Neurons:adrenal_medulla_cell_line 0.06 121.35
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.27, Endothelial_cells:lymphatic:KSHV: 0.26, Endothelial_cells:lymphatic: 0.26, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.26, Endothelial_cells:blood_vessel: 0.26, Endothelial_cells:HUVEC:FPV-infected: 0.26, Endothelial_cells:HUVEC:PR8-infected: 0.26, Endothelial_cells:HUVEC: 0.26, Endothelial_cells:HUVEC:B._anthracis_LT: 0.26, Endothelial_cells:HUVEC:IL-1b: 0.25
T200_AGACAGGTCACACCGG-1 Endothelial_cells:blood_vessel 0.16 119.69
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.4, Endothelial_cells:HUVEC:IFNg: 0.39, Endothelial_cells:HUVEC:FPV-infected: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38
T200_TACGGTACAGGAAGTC-1 Neurons:adrenal_medulla_cell_line 0.06 119.32
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.26, Endothelial_cells:lymphatic: 0.25, Endothelial_cells:lymphatic:KSHV: 0.25, Endothelial_cells:blood_vessel: 0.24, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.24, Endothelial_cells:HUVEC:PR8-infected: 0.24, Endothelial_cells:HUVEC:IL-1b: 0.23, Endothelial_cells:HUVEC: 0.23, Neurons:adrenal_medulla_cell_line: 0.23, Endothelial_cells:HUVEC:FPV-infected: 0.23
T200_GTGCAGCGTGATGAAT-1 Endothelial_cells:lymphatic:TNFa_48h 0.17 118.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.42, Endothelial_cells:lymphatic:KSHV: 0.42, Endothelial_cells:lymphatic: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.4, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.4, Endothelial_cells:HUVEC:B._anthracis_LT: 0.39, Endothelial_cells:HUVEC: 0.39, Endothelial_cells:HUVEC:H5N1-infected: 0.39
T214_AACCAACGTTCCCAAA-1 Endothelial_cells:lymphatic:TNFa_48h 0.21 113.98
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.43, Endothelial_cells:lymphatic:KSHV: 0.43, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.42, Endothelial_cells:HUVEC: 0.41, Endothelial_cells:HUVEC:IL-1b: 0.41, Endothelial_cells:blood_vessel: 0.41, Endothelial_cells:HUVEC:PR8-infected: 0.4, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:HUVEC:VEGF: 0.4, Endothelial_cells:HUVEC:FPV-infected: 0.4
T200_CAAGAGGTCTCCACTG-1 Endothelial_cells:lymphatic 0.08 107.20
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.3, Endothelial_cells:HUVEC:FPV-infected: 0.3, Endothelial_cells:lymphatic: 0.29, Endothelial_cells:HUVEC:PR8-infected: 0.29, Endothelial_cells:HUVEC:H5N1-infected: 0.29, Endothelial_cells:HUVEC:B._anthracis_LT: 0.29, Endothelial_cells:blood_vessel: 0.28, Endothelial_cells:lymphatic:KSHV: 0.28, Endothelial_cells:HUVEC: 0.28, Endothelial_cells:HUVEC:IFNg: 0.28
T69_GGGATGACATTCCTGC.1 Endothelial_cells:HUVEC:IFNg 0.10 104.27
Raw ScoresEndothelial_cells:HUVEC:IFNg: 0.26, Endothelial_cells:lymphatic: 0.26, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.26, Endothelial_cells:lymphatic:TNFa_48h: 0.26, Endothelial_cells:HUVEC:PR8-infected: 0.26, Endothelial_cells:HUVEC:H5N1-infected: 0.26, Endothelial_cells:HUVEC:VEGF: 0.25, Endothelial_cells:HUVEC: 0.25, Endothelial_cells:HUVEC:FPV-infected: 0.25, Endothelial_cells:HUVEC:B._anthracis_LT: 0.25
T19_CCTTTCTGTAGAAGGA.1 Endothelial_cells:lymphatic:TNFa_48h 0.14 102.10
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:lymphatic: 0.4, Endothelial_cells:blood_vessel: 0.38, Endothelial_cells:HUVEC:IFNg: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.37, Endothelial_cells:HUVEC:PR8-infected: 0.37, Endothelial_cells:lymphatic:KSHV: 0.37, Endothelial_cells:HUVEC: 0.37, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.37, Endothelial_cells:HUVEC:H5N1-infected: 0.36
T162_CCGCAAGGTGTAGGAC-1 Smooth_muscle_cells:vascular 0.17 101.20
Raw ScoresMSC: 0.44, Fibroblasts:foreskin: 0.44, iPS_cells:skin_fibroblast: 0.43, Smooth_muscle_cells:vascular: 0.43, iPS_cells:PDB_fibroblasts: 0.43, Tissue_stem_cells:lipoma-derived_MSC: 0.43, iPS_cells:foreskin_fibrobasts: 0.43, Tissue_stem_cells:adipose-derived_MSC_AM3: 0.43, Smooth_muscle_cells:umbilical_vein: 0.42, Tissue_stem_cells:BM_MSC: 0.42
T200_TCTAACTGTATTGAGA-1 Endothelial_cells:lymphatic:TNFa_48h 0.11 95.88
Raw ScoresEndothelial_cells:HUVEC:PR8-infected: 0.34, Endothelial_cells:HUVEC:B._anthracis_LT: 0.33, Endothelial_cells:lymphatic:TNFa_48h: 0.33, Endothelial_cells:HUVEC:H5N1-infected: 0.33, Endothelial_cells:lymphatic: 0.33, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:HUVEC:FPV-infected: 0.32, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.32, Endothelial_cells:HUVEC: 0.32, Endothelial_cells:HUVEC:VEGF: 0.32
T162_TACTGCCCATATCGGT-1 Macrophage:monocyte-derived:S._aureus 0.10 93.72
Raw ScoresMacrophage:monocyte-derived: 0.37, Monocyte:MCSF: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, Macrophage:monocyte-derived:IL-4/cntrl: 0.37, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.36, Monocyte:CXCL4: 0.36, Macrophage:monocyte-derived:IL-4/TGFb: 0.36, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.36, Macrophage:monocyte-derived:M-CSF: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36
T69_ATGAGGGAGCACAGGT.1 Endothelial_cells:HUVEC:Borrelia_burgdorferi 0.08 92.98
Raw ScoresEndothelial_cells:lymphatic: 0.28, Endothelial_cells:HUVEC:PR8-infected: 0.28, Endothelial_cells:lymphatic:TNFa_48h: 0.28, Endothelial_cells:HUVEC:IFNg: 0.28, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.28, Endothelial_cells:HUVEC:H5N1-infected: 0.28, Endothelial_cells:HUVEC:FPV-infected: 0.27, Endothelial_cells:HUVEC:B._anthracis_LT: 0.27, Endothelial_cells:blood_vessel: 0.27, Endothelial_cells:HUVEC: 0.27
T200_TTCGGTCGTCAGCTTA-1 Endothelial_cells:blood_vessel 0.16 91.27
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.4, Endothelial_cells:lymphatic:KSHV: 0.39, Endothelial_cells:lymphatic: 0.39, Endothelial_cells:blood_vessel: 0.39, Endothelial_cells:HUVEC:PR8-infected: 0.38, Endothelial_cells:HUVEC:FPV-infected: 0.38, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.38, Endothelial_cells:HUVEC:B._anthracis_LT: 0.38, Endothelial_cells:HUVEC: 0.38, Endothelial_cells:HUVEC:H5N1-infected: 0.37
T10_TCACAAGGTGTGCCTG.1 Endothelial_cells:lymphatic:TNFa_48h 0.13 89.32
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.35, Endothelial_cells:lymphatic: 0.34, Endothelial_cells:HUVEC:IFNg: 0.33, Endothelial_cells:lymphatic:KSHV: 0.33, Endothelial_cells:blood_vessel: 0.33, Endothelial_cells:HUVEC: 0.33, Endothelial_cells:HUVEC:VEGF: 0.33, Endothelial_cells:HUVEC:Borrelia_burgdorferi: 0.32, Endothelial_cells:HUVEC:B._anthracis_LT: 0.32, Endothelial_cells:HUVEC:IL-1b: 0.32
T69_GCTGGGTTCTCGATGA.1 Epithelial_cells:bronchial 0.06 87.45
Raw ScoresEpithelial_cells:bronchial: 0.26, iPS_cells:CRL2097_foreskin-derived:undiff.: 0.25, iPS_cells:adipose_stem_cell-derived:lentiviral: 0.25, iPS_cells:iPS:minicircle-derived: 0.24, iPS_cells:adipose_stem_cell-derived:minicircle-derived: 0.24, iPS_cells:PDB_2lox-22: 0.24, iPS_cells:PDB_2lox-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:fibroblast-derived:Direct_del._reprog: 0.24, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.24
T200_GCGGAAAGTCAGTTTG-1 Endothelial_cells:blood_vessel 0.15 86.64
Raw ScoresEndothelial_cells:lymphatic:TNFa_48h: 0.38, Endothelial_cells:lymphatic:KSHV: 0.38, Endothelial_cells:blood_vessel: 0.37, Endothelial_cells:lymphatic: 0.37, Endothelial_cells:HUVEC:Serum_Amyloid_A: 0.36, Endothelial_cells:HUVEC:PR8-infected: 0.36, Endothelial_cells:HUVEC:FPV-infected: 0.36, Endothelial_cells:HUVEC:B._anthracis_LT: 0.36, Endothelial_cells:HUVEC: 0.35, Endothelial_cells:HUVEC:H5N1-infected: 0.35


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.93e-03
Mean rank of genes in gene set: 232.67
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
S100A10 0.0037802 87 GTEx DepMap Descartes 12.86 4524.29
IFITM3 0.0027403 138 GTEx DepMap Descartes 21.59 6196.78
B2M 0.0011368 473 GTEx DepMap Descartes 112.36 9441.38


Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.48e-03
Mean rank of genes in gene set: 4090.45
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TM4SF1 0.0096657 19 GTEx DepMap Descartes 6.66 549.27
GJA1 0.0069317 37 GTEx DepMap Descartes 1.69 112.25
HES1 0.0035375 95 GTEx DepMap Descartes 2.65 419.36
SPRY1 0.0023675 176 GTEx DepMap Descartes 3.78 317.67
THBD 0.0019809 240 GTEx DepMap Descartes 0.68 40.16
DUSP6 0.0017865 270 GTEx DepMap Descartes 2.64 138.32
FBLN2 0.0014642 351 GTEx DepMap Descartes 0.41 14.54
JAG1 0.0007404 737 GTEx DepMap Descartes 0.61 30.51
RHOB 0.0006409 860 GTEx DepMap Descartes 4.69 417.03
SHROOM2 0.0003374 1574 GTEx DepMap Descartes 0.09 2.76
CLIC4 0.0003298 1614 GTEx DepMap Descartes 1.28 61.79
FAM102A 0.0002873 1821 GTEx DepMap Descartes 0.18 7.63
MARCKSL1 0.0000636 3954 GTEx DepMap Descartes 8.96 1068.82
LFNG -0.0000231 6102 GTEx DepMap Descartes 0.09 8.28
IVNS1ABP -0.0000825 8482 GTEx DepMap Descartes 1.19 52.35
ADAMTS1 -0.0000937 8908 GTEx DepMap Descartes 0.50 21.65
MCF2L -0.0001493 10527 GTEx DepMap Descartes 0.32 7.95
CDK1 -0.0001829 11228 GTEx DepMap Descartes 0.12 11.79
MECOM -0.0003351 12301 GTEx DepMap Descartes 0.35 11.65
IGFBP3 -0.0005483 12513 GTEx DepMap Descartes 1.46 86.02


Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.11e-03
Mean rank of genes in gene set: 747.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
KDR 0.0024948 164 GTEx DepMap Descartes 1.73 54.98
PTPRB 0.0021239 217 GTEx DepMap Descartes 1.24 17.41
PLVAP 0.0002778 1862 GTEx DepMap Descartes 6.99 512.65




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9959.87
Median rank of genes in gene set: 11516
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
AKAP12 0.0016994 290 GTEx DepMap Descartes 1.28 34.21
FAM107B 0.0008539 654 GTEx DepMap Descartes 0.85 48.00
INO80C 0.0008460 661 GTEx DepMap Descartes 0.57 37.65
RBP1 0.0008412 665 GTEx DepMap Descartes 3.55 376.55
ST3GAL6 0.0008241 676 GTEx DepMap Descartes 0.43 28.79
ARL6IP1 0.0007550 725 GTEx DepMap Descartes 1.84 183.73
ABLIM1 0.0007000 783 GTEx DepMap Descartes 0.68 23.42
CD200 0.0006903 793 GTEx DepMap Descartes 0.97 114.31
LYN 0.0006884 797 GTEx DepMap Descartes 0.58 19.24
SCN3A 0.0006518 843 GTEx DepMap Descartes 0.34 9.33
RPS6KA2 0.0006390 863 GTEx DepMap Descartes 0.89 27.94
GNB1 0.0005521 994 GTEx DepMap Descartes 1.76 114.67
GRB10 0.0005359 1025 GTEx DepMap Descartes 1.11 36.50
SETD7 0.0004922 1113 GTEx DepMap Descartes 0.34 8.48
TMOD2 0.0004209 1298 GTEx DepMap Descartes 0.84 18.71
RET 0.0003744 1429 GTEx DepMap Descartes 0.11 3.53
MYO5A 0.0002904 1805 GTEx DepMap Descartes 0.34 5.80
TBC1D30 0.0002577 1966 GTEx DepMap Descartes 0.19 4.89
EML4 0.0002402 2088 GTEx DepMap Descartes 0.47 21.95
SLC35G2 0.0002374 2113 GTEx DepMap Descartes 0.24 NA
FAM171B 0.0002175 2273 GTEx DepMap Descartes 0.22 8.04
RNF144A 0.0001713 2680 GTEx DepMap Descartes 0.23 9.44
ARHGEF7 0.0001600 2778 GTEx DepMap Descartes 0.53 27.65
NCOA7 0.0001478 2894 GTEx DepMap Descartes 1.77 NA
PHPT1 0.0001422 2943 GTEx DepMap Descartes 2.77 413.24
IGSF3 0.0001302 3080 GTEx DepMap Descartes 0.14 2.99
CETN3 0.0001239 3152 GTEx DepMap Descartes 0.16 15.56
VRK1 0.0001188 3210 GTEx DepMap Descartes 0.19 19.88
AHSA1 0.0001170 3230 GTEx DepMap Descartes 0.86 140.62
TUBB4B 0.0001105 3295 GTEx DepMap Descartes 1.99 197.95


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.47e-50
Mean rank of genes in gene set: 3745.88
Median rank of genes in gene set: 1811
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TFPI 0.0202054 3 GTEx DepMap Descartes 3.38 131.53
TM4SF1 0.0096657 19 GTEx DepMap Descartes 6.66 549.27
RHOJ 0.0086689 24 GTEx DepMap Descartes 0.97 64.38
PLSCR4 0.0084602 26 GTEx DepMap Descartes 0.54 48.73
THBS1 0.0070537 35 GTEx DepMap Descartes 2.42 79.15
GJA1 0.0069317 37 GTEx DepMap Descartes 1.69 112.25
WWTR1 0.0059435 41 GTEx DepMap Descartes 2.12 81.54
MGP 0.0054541 46 GTEx DepMap Descartes 23.28 3758.99
ELK3 0.0044810 65 GTEx DepMap Descartes 2.04 93.81
MYL12B 0.0041831 71 GTEx DepMap Descartes 10.91 1892.16
PDLIM1 0.0040994 75 GTEx DepMap Descartes 2.49 405.79
IL6ST 0.0040639 76 GTEx DepMap Descartes 2.50 62.09
PPIC 0.0037281 90 GTEx DepMap Descartes 1.09 171.39
HES1 0.0035375 95 GTEx DepMap Descartes 2.65 419.36
VIM 0.0035106 97 GTEx DepMap Descartes 45.30 3574.83
NFIA 0.0033173 108 GTEx DepMap Descartes 1.42 7.30
ARL4A 0.0029290 127 GTEx DepMap Descartes 2.15 157.16
PLS3 0.0028886 129 GTEx DepMap Descartes 0.96 72.55
GDF15 0.0028252 133 GTEx DepMap Descartes 0.55 116.10
IFITM3 0.0027403 138 GTEx DepMap Descartes 21.59 6196.78
SASH1 0.0027073 143 GTEx DepMap Descartes 0.69 18.85
LAMC1 0.0026958 145 GTEx DepMap Descartes 1.64 48.88
PON2 0.0026782 149 GTEx DepMap Descartes 1.07 121.77
HTRA1 0.0026467 150 GTEx DepMap Descartes 3.54 297.71
SVIL 0.0026076 152 GTEx DepMap Descartes 1.08 30.77
MYL12A 0.0025633 154 GTEx DepMap Descartes 10.22 1766.90
GNG12 0.0025439 156 GTEx DepMap Descartes 0.51 30.50
F2R 0.0025402 158 GTEx DepMap Descartes 2.34 113.51
TUBB6 0.0025323 159 GTEx DepMap Descartes 1.12 123.97
APP 0.0025167 161 GTEx DepMap Descartes 4.58 264.42


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.83e-01
Mean rank of genes in gene set: 6993.69
Median rank of genes in gene set: 7410
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CLU 0.0021386 213 GTEx DepMap Descartes 3.38 371.35
FDPS 0.0010504 519 GTEx DepMap Descartes 1.96 203.33
SH3BP5 0.0007544 726 GTEx DepMap Descartes 1.80 123.50
PAPSS2 0.0003192 1662 GTEx DepMap Descartes 0.12 6.47
SCAP 0.0002514 2014 GTEx DepMap Descartes 0.34 14.46
IGF1R 0.0002265 2207 GTEx DepMap Descartes 0.32 5.16
CYB5B 0.0002149 2294 GTEx DepMap Descartes 0.57 29.30
POR 0.0001610 2768 GTEx DepMap Descartes 0.39 33.62
SH3PXD2B 0.0001592 2784 GTEx DepMap Descartes 0.07 2.42
FDX1 0.0001048 3353 GTEx DepMap Descartes 0.73 50.51
LDLR 0.0000958 3470 GTEx DepMap Descartes 0.20 6.64
FDXR 0.0000775 3745 GTEx DepMap Descartes 0.14 10.27
DHCR24 0.0000301 4551 GTEx DepMap Descartes 0.07 2.72
ERN1 -0.0000125 5662 GTEx DepMap Descartes 0.11 2.24
MSMO1 -0.0000349 6572 GTEx DepMap Descartes 0.36 30.15
BAIAP2L1 -0.0000436 6926 GTEx DepMap Descartes 0.01 0.44
SGCZ -0.0000443 6946 GTEx DepMap Descartes 0.04 0.64
INHA -0.0000544 7378 GTEx DepMap Descartes 0.00 0.00
NPC1 -0.0000561 7442 GTEx DepMap Descartes 0.09 3.70
STAR -0.0000656 7864 GTEx DepMap Descartes 0.00 0.00
DHCR7 -0.0000989 9071 GTEx DepMap Descartes 0.12 8.58
SCARB1 -0.0000998 9099 GTEx DepMap Descartes 0.22 6.76
FRMD5 -0.0001017 9163 GTEx DepMap Descartes 0.04 1.24
FREM2 -0.0001113 9496 GTEx DepMap Descartes 0.00 0.00
SLC16A9 -0.0001204 9779 GTEx DepMap Descartes 0.01 0.86
PDE10A -0.0001424 10376 GTEx DepMap Descartes 0.18 3.43
GRAMD1B -0.0001461 10455 GTEx DepMap Descartes 0.05 0.97
HMGCR -0.0001728 11034 GTEx DepMap Descartes 0.15 5.66
SLC1A2 -0.0001766 11121 GTEx DepMap Descartes 0.01 0.12
DNER -0.0001939 11385 GTEx DepMap Descartes 0.08 4.51


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10969.66
Median rank of genes in gene set: 12140
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC44A5 0.0000778 3741 GTEx DepMap Descartes 0.03 1.49
RYR2 0.0000060 5040 GTEx DepMap Descartes 0.08 0.86
REEP1 -0.0000517 7261 GTEx DepMap Descartes 0.15 5.81
GREM1 -0.0000520 7280 GTEx DepMap Descartes 0.19 2.21
ANKFN1 -0.0000636 7800 GTEx DepMap Descartes 0.00 0.00
IL7 -0.0000705 8044 GTEx DepMap Descartes 0.15 19.88
EPHA6 -0.0000760 8249 GTEx DepMap Descartes 0.00 0.00
RPH3A -0.0001033 9220 GTEx DepMap Descartes 0.04 0.76
FAT3 -0.0001225 9844 GTEx DepMap Descartes 0.08 0.74
ALK -0.0001436 10406 GTEx DepMap Descartes 0.01 0.27
HS3ST5 -0.0001475 10489 GTEx DepMap Descartes 0.01 0.40
KCNB2 -0.0001499 10540 GTEx DepMap Descartes 0.01 0.78
EYA1 -0.0001687 10949 GTEx DepMap Descartes 0.03 0.75
EYA4 -0.0001703 10985 GTEx DepMap Descartes 0.00 0.00
PTCHD1 -0.0001805 11186 GTEx DepMap Descartes 0.01 0.17
CNKSR2 -0.0002086 11573 GTEx DepMap Descartes 0.04 0.71
TMEM132C -0.0002156 11656 GTEx DepMap Descartes 0.00 0.00
SLC6A2 -0.0002182 11677 GTEx DepMap Descartes 0.04 1.33
PLXNA4 -0.0002223 11719 GTEx DepMap Descartes 0.00 0.00
RBFOX1 -0.0002610 12022 GTEx DepMap Descartes 0.05 1.48
MAB21L2 -0.0002863 12140 GTEx DepMap Descartes 0.26 10.97
TMEFF2 -0.0003007 12203 GTEx DepMap Descartes 0.07 2.83
RGMB -0.0003056 12217 GTEx DepMap Descartes 0.20 6.59
SYNPO2 -0.0003111 12230 GTEx DepMap Descartes 0.07 0.75
MAB21L1 -0.0003136 12242 GTEx DepMap Descartes 0.34 14.54
NTRK1 -0.0003385 12318 GTEx DepMap Descartes 0.07 3.16
MARCH11 -0.0003432 12327 GTEx DepMap Descartes 0.64 NA
TUBA1A -0.0003465 12333 GTEx DepMap Descartes 13.09 1126.82
GAL -0.0003568 12352 GTEx DepMap Descartes 0.11 17.65
ELAVL2 -0.0003594 12359 GTEx DepMap Descartes 0.23 7.27


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.84e-13
Mean rank of genes in gene set: 2069.5
Median rank of genes in gene set: 274.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TIE1 0.0119550 11 GTEx DepMap Descartes 1.80 103.10
CLDN5 0.0119000 12 GTEx DepMap Descartes 9.36 919.28
FLT4 0.0118141 13 GTEx DepMap Descartes 0.96 44.45
KANK3 0.0075246 31 GTEx DepMap Descartes 1.03 85.75
ROBO4 0.0075007 32 GTEx DepMap Descartes 2.05 111.71
CALCRL 0.0059335 42 GTEx DepMap Descartes 1.80 73.40
CDH5 0.0051366 51 GTEx DepMap Descartes 2.68 118.29
RAMP2 0.0048394 56 GTEx DepMap Descartes 8.88 2052.15
F8 0.0041786 72 GTEx DepMap Descartes 0.15 4.24
NPR1 0.0039778 81 GTEx DepMap Descartes 0.39 20.46
ARHGAP29 0.0039395 82 GTEx DepMap Descartes 4.07 90.81
HYAL2 0.0038142 85 GTEx DepMap Descartes 4.39 235.67
RASIP1 0.0036849 94 GTEx DepMap Descartes 1.05 69.68
SHE 0.0033581 105 GTEx DepMap Descartes 0.45 15.19
PODXL 0.0029634 126 GTEx DepMap Descartes 2.47 77.54
KDR 0.0024948 164 GTEx DepMap Descartes 1.73 54.98
PTPRB 0.0021239 217 GTEx DepMap Descartes 1.24 17.41
TEK 0.0020465 230 GTEx DepMap Descartes 0.26 7.71
ID1 0.0020059 236 GTEx DepMap Descartes 4.84 767.14
CEACAM1 0.0015929 313 GTEx DepMap Descartes 0.16 11.16
GALNT15 0.0010633 512 GTEx DepMap Descartes 0.20 NA
NR5A2 0.0010131 543 GTEx DepMap Descartes 0.16 5.44
ESM1 0.0009354 581 GTEx DepMap Descartes 1.38 125.20
SHANK3 0.0009199 596 GTEx DepMap Descartes 0.42 8.80
MMRN2 0.0007906 701 GTEx DepMap Descartes 1.30 55.07
SLCO2A1 0.0007264 754 GTEx DepMap Descartes 0.69 29.63
CDH13 0.0006077 899 GTEx DepMap Descartes 0.59 16.22
PLVAP 0.0002778 1862 GTEx DepMap Descartes 6.99 512.65
NOTCH4 0.0001997 2421 GTEx DepMap Descartes 1.14 33.81
EFNB2 0.0001440 2924 GTEx DepMap Descartes 1.32 41.96


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 7836.55
Median rank of genes in gene set: 9480
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MGP 0.0054541 46 GTEx DepMap Descartes 23.28 3758.99
LOX 0.0030114 124 GTEx DepMap Descartes 0.85 47.41
LAMC3 0.0025201 160 GTEx DepMap Descartes 0.04 1.14
ADAMTSL3 0.0018369 261 GTEx DepMap Descartes 0.07 2.75
ELN 0.0006232 881 GTEx DepMap Descartes 0.50 26.38
C7 0.0003560 1499 GTEx DepMap Descartes 0.27 14.72
ABCC9 0.0002839 1840 GTEx DepMap Descartes 0.11 4.20
COL27A1 0.0002185 2265 GTEx DepMap Descartes 0.15 7.47
ACTA2 0.0001297 3095 GTEx DepMap Descartes 0.73 89.24
ABCA6 0.0001081 3317 GTEx DepMap Descartes 0.07 2.47
RSPO3 0.0001005 3401 GTEx DepMap Descartes 0.07 NA
CCDC80 0.0000206 4753 GTEx DepMap Descartes 0.64 9.36
PRICKLE1 -0.0000057 5394 GTEx DepMap Descartes 0.09 3.12
SCARA5 -0.0000380 6712 GTEx DepMap Descartes 0.00 0.00
PAMR1 -0.0000403 6791 GTEx DepMap Descartes 0.01 1.20
CDH11 -0.0000526 7305 GTEx DepMap Descartes 0.09 2.31
EDNRA -0.0000533 7333 GTEx DepMap Descartes 0.08 4.16
BICC1 -0.0000676 7937 GTEx DepMap Descartes 0.09 3.82
GAS2 -0.0000723 8119 GTEx DepMap Descartes 0.00 0.00
GLI2 -0.0000956 8974 GTEx DepMap Descartes 0.00 0.00
CLDN11 -0.0001008 9131 GTEx DepMap Descartes 0.00 0.00
HHIP -0.0001065 9335 GTEx DepMap Descartes 0.05 0.85
FREM1 -0.0001155 9625 GTEx DepMap Descartes 0.00 0.00
DKK2 -0.0001165 9658 GTEx DepMap Descartes 0.03 1.98
PCDH18 -0.0001179 9703 GTEx DepMap Descartes 0.04 1.00
ITGA11 -0.0001236 9874 GTEx DepMap Descartes 0.01 0.20
LUM -0.0001255 9930 GTEx DepMap Descartes 1.28 131.27
PRRX1 -0.0001361 10225 GTEx DepMap Descartes 0.23 13.86
CD248 -0.0001388 10289 GTEx DepMap Descartes 0.05 4.31
COL12A1 -0.0001534 10626 GTEx DepMap Descartes 0.32 5.20


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9488.03
Median rank of genes in gene set: 9394
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PENK 0.0000334 4485 GTEx DepMap Descartes 0.04 3.72
ST18 -0.0000136 5698 GTEx DepMap Descartes 0.01 0.27
GRM7 -0.0000287 6306 GTEx DepMap Descartes 0.00 0.00
KSR2 -0.0000354 6599 GTEx DepMap Descartes 0.03 0.37
CDH18 -0.0000556 7426 GTEx DepMap Descartes 0.01 0.60
SORCS3 -0.0000558 7434 GTEx DepMap Descartes 0.00 0.00
TBX20 -0.0000603 7641 GTEx DepMap Descartes 0.00 0.00
CNTN3 -0.0000650 7845 GTEx DepMap Descartes 0.00 0.00
LAMA3 -0.0000661 7880 GTEx DepMap Descartes 0.03 0.40
SLC24A2 -0.0000683 7957 GTEx DepMap Descartes 0.00 0.00
SLC35F3 -0.0000739 8179 GTEx DepMap Descartes 0.00 0.00
DGKK -0.0000825 8481 GTEx DepMap Descartes 0.01 0.21
TENM1 -0.0000862 8637 GTEx DepMap Descartes 0.01 NA
HTATSF1 -0.0000936 8907 GTEx DepMap Descartes 0.51 34.58
GALNTL6 -0.0000943 8926 GTEx DepMap Descartes 0.01 0.37
MGAT4C -0.0000986 9066 GTEx DepMap Descartes 0.04 0.32
CDH12 -0.0000989 9072 GTEx DepMap Descartes 0.00 0.00
CCSER1 -0.0000997 9097 GTEx DepMap Descartes 0.01 NA
PCSK2 -0.0001051 9290 GTEx DepMap Descartes 0.00 0.00
GRID2 -0.0001114 9498 GTEx DepMap Descartes 0.05 1.29
FAM155A -0.0001177 9694 GTEx DepMap Descartes 0.20 3.21
EML6 -0.0001248 9909 GTEx DepMap Descartes 0.00 0.00
PACRG -0.0001311 10101 GTEx DepMap Descartes 0.01 0.92
AGBL4 -0.0001312 10105 GTEx DepMap Descartes 0.00 0.00
FGF14 -0.0001410 10344 GTEx DepMap Descartes 0.01 0.11
SPOCK3 -0.0001554 10670 GTEx DepMap Descartes 0.00 0.00
UNC80 -0.0001630 10832 GTEx DepMap Descartes 0.09 0.81
TIAM1 -0.0001686 10948 GTEx DepMap Descartes 0.09 3.92
NTNG1 -0.0001909 11338 GTEx DepMap Descartes 0.08 2.52
KCTD16 -0.0001945 11391 GTEx DepMap Descartes 0.09 0.93


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.71e-02
Mean rank of genes in gene set: 5268.55
Median rank of genes in gene set: 4733
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GYPC 0.0033570 106 GTEx DepMap Descartes 3.38 439.70
TSPAN5 0.0012641 412 GTEx DepMap Descartes 0.89 50.99
MICAL2 0.0010499 520 GTEx DepMap Descartes 0.24 8.78
MARCH3 0.0007676 715 GTEx DepMap Descartes 0.39 NA
GCLC 0.0003474 1536 GTEx DepMap Descartes 0.04 3.17
BLVRB 0.0003140 1687 GTEx DepMap Descartes 1.03 128.81
SNCA 0.0002338 2149 GTEx DepMap Descartes 0.36 26.65
XPO7 0.0002260 2211 GTEx DepMap Descartes 0.20 9.55
CAT 0.0002060 2366 GTEx DepMap Descartes 0.28 29.74
TRAK2 0.0001964 2443 GTEx DepMap Descartes 0.27 13.77
RGS6 0.0001707 2690 GTEx DepMap Descartes 0.00 0.00
DENND4A 0.0001323 3059 GTEx DepMap Descartes 0.26 6.86
CPOX 0.0001045 3354 GTEx DepMap Descartes 0.14 12.53
SLC25A37 0.0000830 3669 GTEx DepMap Descartes 0.51 35.30
SLC25A21 0.0000215 4733 GTEx DepMap Descartes 0.00 0.00
RAPGEF2 -0.0000226 6077 GTEx DepMap Descartes 0.39 12.76
RHD -0.0000248 6172 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0000258 6215 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000313 6434 GTEx DepMap Descartes 0.00 0.00
TMCC2 -0.0000823 8474 GTEx DepMap Descartes 0.04 1.92
SELENBP1 -0.0001019 9168 GTEx DepMap Descartes 0.04 5.01
ABCB10 -0.0001034 9225 GTEx DepMap Descartes 0.05 1.69
EPB41 -0.0001071 9355 GTEx DepMap Descartes 0.19 4.11
TFR2 -0.0001135 9568 GTEx DepMap Descartes 0.00 0.00
SPTB -0.0001183 9716 GTEx DepMap Descartes 0.01 0.22
ANK1 -0.0001208 9789 GTEx DepMap Descartes 0.03 0.30
FECH -0.0001210 9796 GTEx DepMap Descartes 0.03 0.76
SPECC1 -0.0001250 9913 GTEx DepMap Descartes 0.07 1.07
SOX6 -0.0001835 11236 GTEx DepMap Descartes 0.01 0.16
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.32e-01
Mean rank of genes in gene set: 6174.87
Median rank of genes in gene set: 6338
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PTPRE 0.0022590 194 GTEx DepMap Descartes 0.99 35.51
SLC9A9 0.0008644 646 GTEx DepMap Descartes 0.20 10.94
CST3 0.0005082 1077 GTEx DepMap Descartes 8.22 550.51
LGMN 0.0004654 1187 GTEx DepMap Descartes 1.62 143.13
WWP1 0.0004410 1246 GTEx DepMap Descartes 0.42 20.32
SLCO2B1 0.0003798 1415 GTEx DepMap Descartes 0.24 6.94
MERTK 0.0003490 1530 GTEx DepMap Descartes 0.14 4.83
RGL1 0.0002490 2029 GTEx DepMap Descartes 0.26 8.72
FGL2 0.0001694 2701 GTEx DepMap Descartes 0.34 11.64
CD163L1 0.0000955 3473 GTEx DepMap Descartes 0.08 4.98
IFNGR1 0.0000944 3484 GTEx DepMap Descartes 0.53 49.15
HRH1 0.0000937 3494 GTEx DepMap Descartes 0.09 2.85
FGD2 0.0000893 3578 GTEx DepMap Descartes 0.01 1.36
SFMBT2 0.0000872 3609 GTEx DepMap Descartes 0.05 1.27
ITPR2 0.0000710 3831 GTEx DepMap Descartes 0.26 4.89
CTSS 0.0000627 3966 GTEx DepMap Descartes 1.08 51.84
CSF1R 0.0000416 4333 GTEx DepMap Descartes 0.12 5.26
CD74 -0.0000003 5236 GTEx DepMap Descartes 13.50 827.43
HCK -0.0000075 5460 GTEx DepMap Descartes 0.09 6.15
ATP8B4 -0.0000504 7216 GTEx DepMap Descartes 0.00 0.00
CPVL -0.0000598 7610 GTEx DepMap Descartes 0.12 15.09
SLC1A3 -0.0000612 7679 GTEx DepMap Descartes 0.03 1.18
MS4A4A -0.0000755 8233 GTEx DepMap Descartes 0.30 18.09
ADAP2 -0.0000764 8262 GTEx DepMap Descartes 0.08 3.08
CTSB -0.0000889 8741 GTEx DepMap Descartes 4.70 229.90
CYBB -0.0000891 8748 GTEx DepMap Descartes 0.05 0.76
AXL -0.0000953 8957 GTEx DepMap Descartes 0.16 5.97
CTSD -0.0000965 8997 GTEx DepMap Descartes 4.74 424.01
ABCA1 -0.0001047 9278 GTEx DepMap Descartes 0.20 3.46
MSR1 -0.0001206 9782 GTEx DepMap Descartes 0.19 7.39


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.66e-01
Mean rank of genes in gene set: 6364.93
Median rank of genes in gene set: 6378
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LAMA4 0.0058328 43 GTEx DepMap Descartes 4.05 131.52
EDNRB 0.0044186 67 GTEx DepMap Descartes 0.99 44.06
VIM 0.0035106 97 GTEx DepMap Descartes 45.30 3574.83
LAMC1 0.0026958 145 GTEx DepMap Descartes 1.64 48.88
KCTD12 0.0023284 182 GTEx DepMap Descartes 0.97 34.30
ADAMTS5 0.0015052 339 GTEx DepMap Descartes 0.59 9.49
COL5A2 0.0014765 348 GTEx DepMap Descartes 0.62 18.24
LAMB1 0.0013288 387 GTEx DepMap Descartes 1.53 53.39
MARCKS 0.0005849 948 GTEx DepMap Descartes 7.96 360.64
STARD13 0.0003098 1708 GTEx DepMap Descartes 0.19 6.54
COL18A1 0.0002984 1759 GTEx DepMap Descartes 2.66 90.02
VCAN 0.0001736 2653 GTEx DepMap Descartes 0.88 14.74
HMGA2 0.0001595 2782 GTEx DepMap Descartes 0.04 1.17
DST 0.0000594 4024 GTEx DepMap Descartes 1.28 12.55
COL25A1 0.0000591 4032 GTEx DepMap Descartes 0.07 1.63
OLFML2A 0.0000441 4299 GTEx DepMap Descartes 0.36 9.47
EGFLAM 0.0000324 4501 GTEx DepMap Descartes 0.16 6.17
PLCE1 0.0000304 4544 GTEx DepMap Descartes 0.05 0.53
GAS7 0.0000129 4904 GTEx DepMap Descartes 0.11 2.67
MPZ -0.0000048 5366 GTEx DepMap Descartes 0.22 15.25
MDGA2 -0.0000091 5528 GTEx DepMap Descartes 0.00 0.00
TRPM3 -0.0000141 5718 GTEx DepMap Descartes 0.01 0.17
IL1RAPL1 -0.0000465 7038 GTEx DepMap Descartes 0.00 0.00
IL1RAPL2 -0.0000642 7815 GTEx DepMap Descartes 0.00 0.00
ERBB4 -0.0000800 8377 GTEx DepMap Descartes 0.00 0.00
PLP1 -0.0000898 8766 GTEx DepMap Descartes 0.16 6.65
NRXN3 -0.0000900 8779 GTEx DepMap Descartes 0.01 0.26
XKR4 -0.0001029 9206 GTEx DepMap Descartes 0.05 0.32
GRIK3 -0.0001062 9321 GTEx DepMap Descartes 0.00 0.00
SLC35F1 -0.0001073 9367 GTEx DepMap Descartes 0.03 0.73


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.42e-04
Mean rank of genes in gene set: 4318.09
Median rank of genes in gene set: 1707
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MMRN1 0.0220120 1 GTEx DepMap Descartes 2.42 142.01
THBS1 0.0070537 35 GTEx DepMap Descartes 2.42 79.15
LIMS1 0.0046370 59 GTEx DepMap Descartes 3.65 184.20
ITGB3 0.0025408 157 GTEx DepMap Descartes 0.03 1.37
TRPC6 0.0022026 201 GTEx DepMap Descartes 0.08 4.58
CD9 0.0019912 239 GTEx DepMap Descartes 3.58 431.02
TPM4 0.0016791 296 GTEx DepMap Descartes 5.35 231.98
TGFB1 0.0015702 323 GTEx DepMap Descartes 2.09 162.17
STON2 0.0013806 374 GTEx DepMap Descartes 0.16 9.77
MYH9 0.0011995 446 GTEx DepMap Descartes 2.78 79.75
LTBP1 0.0011916 449 GTEx DepMap Descartes 0.15 4.63
STOM 0.0011817 452 GTEx DepMap Descartes 2.28 151.95
ARHGAP6 0.0010907 492 GTEx DepMap Descartes 0.23 7.24
MCTP1 0.0009423 578 GTEx DepMap Descartes 0.32 14.93
FLI1 0.0009227 595 GTEx DepMap Descartes 0.43 15.26
TLN1 0.0009096 607 GTEx DepMap Descartes 1.30 29.82
FLNA 0.0008894 625 GTEx DepMap Descartes 2.47 58.30
ACTN1 0.0008478 658 GTEx DepMap Descartes 1.15 55.35
TMSB4X 0.0006282 877 GTEx DepMap Descartes 100.12 12725.40
RAP1B 0.0005792 955 GTEx DepMap Descartes 1.72 26.64
VCL 0.0004203 1300 GTEx DepMap Descartes 0.51 14.24
ACTB 0.0004141 1317 GTEx DepMap Descartes 33.70 3044.56
ZYX 0.0003103 1707 GTEx DepMap Descartes 0.76 72.05
INPP4B 0.0001367 3010 GTEx DepMap Descartes 0.11 2.98
GSN 0.0001201 3193 GTEx DepMap Descartes 4.78 143.35
GP1BA 0.0001010 3394 GTEx DepMap Descartes 0.09 5.30
TUBB1 0.0000985 3435 GTEx DepMap Descartes 0.00 0.00
RAB27B -0.0000220 6043 GTEx DepMap Descartes 0.01 0.21
SLC24A3 -0.0000278 6281 GTEx DepMap Descartes 0.03 0.81
FERMT3 -0.0000304 6388 GTEx DepMap Descartes 0.20 14.56


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 7754.6
Median rank of genes in gene set: 10098
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SP100 0.0017125 285 GTEx DepMap Descartes 1.78 71.12
B2M 0.0011368 473 GTEx DepMap Descartes 112.36 9441.38
MSN 0.0009142 602 GTEx DepMap Descartes 3.19 159.80
ABLIM1 0.0007000 783 GTEx DepMap Descartes 0.68 23.42
ARID5B 0.0005933 933 GTEx DepMap Descartes 0.95 25.69
TMSB10 0.0005855 947 GTEx DepMap Descartes 72.32 30953.80
PRKCH 0.0004537 1213 GTEx DepMap Descartes 0.59 32.73
MBNL1 0.0003895 1388 GTEx DepMap Descartes 1.09 41.45
ETS1 0.0003684 1451 GTEx DepMap Descartes 1.51 53.47
ITPKB 0.0002555 1984 GTEx DepMap Descartes 0.24 11.05
FOXP1 0.0001723 2668 GTEx DepMap Descartes 0.89 20.59
RCSD1 0.0001444 2922 GTEx DepMap Descartes 0.18 9.23
CCND3 0.0000904 3557 GTEx DepMap Descartes 0.46 38.65
NCALD -0.0000194 5942 GTEx DepMap Descartes 0.19 9.19
MCTP2 -0.0000201 5974 GTEx DepMap Descartes 0.08 2.37
WIPF1 -0.0000419 6855 GTEx DepMap Descartes 0.45 18.67
CCL5 -0.0000593 7589 GTEx DepMap Descartes 0.09 10.70
DOCK10 -0.0000726 8131 GTEx DepMap Descartes 0.16 3.65
PITPNC1 -0.0000885 8730 GTEx DepMap Descartes 0.30 6.66
SAMD3 -0.0001185 9721 GTEx DepMap Descartes 0.01 0.45
PLEKHA2 -0.0001241 9888 GTEx DepMap Descartes 0.07 2.24
BACH2 -0.0001397 10308 GTEx DepMap Descartes 0.09 1.22
SKAP1 -0.0001474 10485 GTEx DepMap Descartes 0.07 5.26
ARHGAP15 -0.0001594 10770 GTEx DepMap Descartes 0.07 4.78
SCML4 -0.0001726 11030 GTEx DepMap Descartes 0.01 0.50
SORL1 -0.0001836 11239 GTEx DepMap Descartes 0.05 0.81
GNG2 -0.0001910 11340 GTEx DepMap Descartes 0.53 27.87
LEF1 -0.0001985 11442 GTEx DepMap Descartes 0.31 18.85
PDE3B -0.0001993 11452 GTEx DepMap Descartes 0.01 0.48
IKZF1 -0.0001997 11457 GTEx DepMap Descartes 0.04 0.61


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.26e-03
Mean rank of genes in gene set: 773.67
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CLDN5 0.0119000 12 GTEx DepMap Descartes 9.36 919.28
SPARCL1 0.0011963 447 GTEx DepMap Descartes 10.42 766.15
PLVAP 0.0002778 1862 GTEx DepMap Descartes 6.99 512.65


Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.44e-02
Mean rank of genes in gene set: 2317
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
VWF 0.0046105 61 GTEx DepMap Descartes 10.69 235.16
MMRN2 0.0007906 701 GTEx DepMap Descartes 1.30 55.07
RAMP3 0.0004025 1356 GTEx DepMap Descartes 2.76 347.93
JAM2 -0.0000491 7150 GTEx DepMap Descartes 0.74 36.88


pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.92e-02
Mean rank of genes in gene set: 973.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CCDC50 0.0009731 563 GTEx DepMap Descartes 1.68 36.99
IRF7 0.0003916 1384 GTEx DepMap Descartes 1.03 110.25