Program: 17. Cancer Associated Fibroblast: Myofibroblast (POSTN+).

Program: 17. Cancer Associated Fibroblast: Myofibroblast (POSTN+).

Program description and justification of annotation: 17.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 COL1A1 0.0310094 collagen type I alpha 1 chain GTEx DepMap Descartes 12.50 4506.94
2 COL3A1 0.0253399 collagen type III alpha 1 chain GTEx DepMap Descartes 9.04 3626.58
3 COL1A2 0.0241917 collagen type I alpha 2 chain GTEx DepMap Descartes 15.10 6019.95
4 LUM 0.0169930 lumican GTEx DepMap Descartes 1.45 1247.53
5 SFRP4 0.0160959 secreted frizzled related protein 4 GTEx DepMap Descartes 1.21 1044.45
6 COMP 0.0158930 cartilage oligomeric matrix protein GTEx DepMap Descartes 3.11 3004.51
7 SPARC 0.0157295 secreted protein acidic and cysteine rich GTEx DepMap Descartes 4.67 2862.77
8 POSTN 0.0154492 periostin GTEx DepMap Descartes 2.22 1299.99
9 FN1 0.0152264 fibronectin 1 GTEx DepMap Descartes 6.08 1259.02
10 LRRC15 0.0121414 leucine rich repeat containing 15 GTEx DepMap Descartes 0.15 45.74
11 DCN 0.0121242 decorin GTEx DepMap Descartes 1.03 340.72
12 COL6A3 0.0108987 collagen type VI alpha 3 chain GTEx DepMap Descartes 1.58 306.95
13 COL5A2 0.0101766 collagen type V alpha 2 chain GTEx DepMap Descartes 2.70 846.73
14 COL5A1 0.0100927 collagen type V alpha 1 chain GTEx DepMap Descartes 1.25 320.84
15 COL6A2 0.0097484 collagen type VI alpha 2 chain GTEx DepMap Descartes 2.18 1226.54
16 SULF1 0.0094637 sulfatase 1 GTEx DepMap Descartes 2.75 871.54
17 FBN1 0.0092829 fibrillin 1 GTEx DepMap Descartes 1.49 251.75
18 BGN 0.0090765 biglycan GTEx DepMap Descartes 1.24 1260.80
19 COL12A1 0.0088718 collagen type XII alpha 1 chain GTEx DepMap Descartes 1.27 243.95
20 AEBP1 0.0085236 AE binding protein 1 GTEx DepMap Descartes 2.82 1557.76
21 FSTL1 0.0082068 follistatin like 1 GTEx DepMap Descartes 1.18 455.96
22 COL8A1 0.0072234 collagen type VIII alpha 1 chain GTEx DepMap Descartes 1.42 562.05
23 CCDC80 0.0063788 coiled-coil domain containing 80 GTEx DepMap Descartes 0.59 96.66
24 VCAN 0.0063658 versican GTEx DepMap Descartes 2.01 319.34
25 MFAP5 0.0063303 microfibril associated protein 5 GTEx DepMap Descartes 0.22 131.07
26 TIMP1 0.0060792 TIMP metallopeptidase inhibitor 1 GTEx DepMap Descartes 3.41 5827.85
27 TNC 0.0059465 tenascin C GTEx DepMap Descartes 0.86 207.24
28 PRRX1 0.0058900 paired related homeobox 1 GTEx DepMap Descartes 0.69 406.64
29 MGP 0.0058735 matrix Gla protein GTEx DepMap Descartes 1.57 1945.74
30 COL6A1 0.0054267 collagen type VI alpha 1 chain GTEx DepMap Descartes 1.31 656.95
31 IGFBP4 0.0052888 insulin like growth factor binding protein 4 GTEx DepMap Descartes 0.99 872.96
32 SERPINF1 0.0052525 serpin family F member 1 GTEx DepMap Descartes 0.53 716.22
33 THBS2 0.0051111 thrombospondin 2 GTEx DepMap Descartes 1.75 690.25
34 GXYLT2 0.0050079 glucoside xylosyltransferase 2 GTEx DepMap Descartes 0.44 306.17
35 CDH11 0.0049520 cadherin 11 GTEx DepMap Descartes 1.02 311.34
36 PRSS23 0.0048677 serine protease 23 GTEx DepMap Descartes 0.70 243.03
37 CCDC8 0.0048555 coiled-coil domain containing 8 GTEx DepMap Descartes 0.06 35.22
38 SFRP2 0.0048395 secreted frizzled related protein 2 GTEx DepMap Descartes 0.61 677.97
39 CRISPLD2 0.0047971 cysteine rich secretory protein LCCL domain containing 2 GTEx DepMap Descartes 0.89 477.47
40 CTHRC1 0.0047768 collagen triple helix repeat containing 1 GTEx DepMap Descartes 0.50 811.95
41 BNC2 0.0047459 basonuclin 2 GTEx DepMap Descartes 1.31 215.02
42 ISLR 0.0046990 immunoglobulin superfamily containing leucine rich repeat GTEx DepMap Descartes 0.47 455.58
43 LOX 0.0046669 lysyl oxidase GTEx DepMap Descartes 0.22 114.45
44 TAGLN 0.0046021 transgelin GTEx DepMap Descartes 0.69 337.72
45 COL11A1 0.0045260 collagen type XI alpha 1 chain GTEx DepMap Descartes 0.63 173.00
46 FBLN1 0.0044045 fibulin 1 GTEx DepMap Descartes 0.61 514.49
47 ADAMTS12 0.0043733 ADAM metallopeptidase with thrombospondin type 1 motif 12 GTEx DepMap Descartes 0.43 87.16
48 MMP2 0.0043308 matrix metallopeptidase 2 GTEx DepMap Descartes 0.84 577.86
49 DPT 0.0042170 dermatopontin GTEx DepMap Descartes 0.09 94.46
50 IGFBP7 0.0041212 insulin like growth factor binding protein 7 GTEx DepMap Descartes 2.70 3260.98


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UMAP plots showing activity of gene expression program identified in community:17. Cancer Associated Fibroblast: Myofibroblast (POSTN+)

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DESCARTES_FETAL_EYE_STROMAL_CELLS 1.79e-37 157.96 82.08 4.01e-35 1.20e-34
23COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, FN1, DCN, COL6A3, COL5A2, COL5A1, COL6A2, FBN1, COL12A1, MFAP5, MGP, COL6A1, THBS2, SFRP2, CTHRC1, ISLR, LOX, DPT
 90
DESCARTES_FETAL_THYMUS_STROMAL_CELLS 3.38e-43 145.35 77.59 2.27e-40 2.27e-40
28COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, DCN, COL5A2, COL5A1, FBN1, BGN, COL12A1, FSTL1, CCDC80, VCAN, MFAP5, TIMP1, PRRX1, MGP, COL6A1, THBS2, GXYLT2, CCDC8, SFRP2, ISLR, LOX, FBLN1, MMP2
 137
CUI_DEVELOPING_HEART_COMPACT_VENTRICULAR_CARDIOMYOCYTE 7.96e-30 148.90 73.40 5.93e-28 5.34e-27
18COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, FN1, DCN, COL6A3, COL5A2, COL5A1, COL6A2, FBN1, COL12A1, MGP, COL6A1, MMP2, DPT
 65
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS 5.87e-32 133.72 68.04 5.63e-30 3.94e-29
20COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, DCN, COL6A2, BGN, AEBP1, TIMP1, PRRX1, MGP, IGFBP4, SERPINF1, CDH11, SFRP2, TAGLN, FBLN1, IGFBP7
 82
GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR 3.42e-32 115.63 59.97 3.83e-30 2.30e-29
21COL1A1, COL3A1, COL1A2, LUM, SPARC, DCN, COL5A2, COL5A1, COL8A1, CCDC80, VCAN, MGP, SERPINF1, THBS2, SFRP2, CTHRC1, ISLR, LOX, FBLN1, MMP2, DPT
 99
CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL 1.45e-34 112.95 59.53 1.94e-32 9.70e-32
23COL1A1, COL1A2, LUM, SPARC, DCN, COL6A3, COL5A2, COL5A1, COL6A2, FBN1, COL12A1, FSTL1, TIMP1, MGP, COL6A1, SERPINF1, THBS2, ISLR, LOX, FBLN1, MMP2, DPT, IGFBP7
 117
CUI_DEVELOPING_HEART_SMOOTH_MUSCLE_CELL 2.31e-19 109.27 48.03 8.60e-18 1.55e-16
12COL1A1, COL3A1, COL1A2, SPARC, BGN, CCDC80, MFAP5, IGFBP4, SERPINF1, SFRP2, LOX, FBLN1
 48
AIZARANI_LIVER_C21_STELLATE_CELLS_1 8.84e-35 80.51 43.47 1.48e-32 5.93e-32
26COL1A1, COL3A1, COL1A2, LUM, SPARC, DCN, COL6A3, COL5A1, COL6A2, FBN1, BGN, AEBP1, FSTL1, CCDC80, TIMP1, MGP, COL6A1, IGFBP4, SERPINF1, THBS2, PRSS23, CRISPLD2, FBLN1, MMP2, DPT, IGFBP7
 194
DESCARTES_FETAL_HEART_STROMAL_CELLS 5.62e-15 109.51 42.23 1.71e-13 3.77e-12
9COL1A1, COL1A2, LUM, DCN, MFAP5, SERPINF1, ISLR, FBLN1, DPT
 34
RUBENSTEIN_SKELETAL_MUSCLE_FAP_CELLS 3.06e-28 62.59 33.26 1.93e-26 2.05e-25
22COL1A1, COL3A1, COL1A2, LUM, SFRP4, FN1, DCN, COL6A3, COL6A2, FSTL1, CCDC80, VCAN, MFAP5, TIMP1, MGP, COL6A1, SERPINF1, ISLR, FBLN1, MMP2, DPT, IGFBP7
 179
DESCARTES_FETAL_KIDNEY_STROMAL_CELLS 9.59e-25 60.22 31.29 4.29e-23 6.44e-22
19COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, DCN, SULF1, FBN1, COL12A1, MFAP5, PRRX1, MGP, SERPINF1, THBS2, SFRP2, ISLR, LOX, DPT
 146
MURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL 1.48e-37 55.36 28.62 4.01e-35 9.94e-35
37COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, FN1, DCN, COL6A3, COL5A2, COL5A1, COL6A2, SULF1, FBN1, BGN, COL12A1, AEBP1, FSTL1, COL8A1, CCDC80, VCAN, TIMP1, TNC, PRRX1, MGP, COL6A1, IGFBP4, SERPINF1, THBS2, CDH11, SFRP2, CRISPLD2, CTHRC1, ISLR, LOX, MMP2, IGFBP7
 680
MENON_FETAL_KIDNEY_3_STROMAL_CELLS 2.07e-16 57.07 26.00 6.94e-15 1.39e-13
12COL1A1, COL3A1, COL1A2, SPARC, POSTN, FN1, COL6A3, COL5A2, FSTL1, VCAN, TNC, CDH11
 81
DESCARTES_MAIN_FETAL_STROMAL_CELLS 1.20e-08 92.39 25.13 2.69e-07 8.07e-06
5COL1A1, COL1A2, COL5A1, COL12A1, THBS2
 20
TRAVAGLINI_LUNG_ADVENTITIAL_FIBROBLAST_CELL 3.16e-28 46.14 25.06 1.93e-26 2.12e-25
25COL1A1, COL3A1, COL1A2, LUM, SFRP4, DCN, COL6A3, COL6A2, FBN1, FSTL1, CCDC80, MFAP5, TIMP1, PRRX1, MGP, COL6A1, IGFBP4, SERPINF1, THBS2, SFRP2, ISLR, LOX, FBLN1, MMP2, DPT
 296
DESCARTES_FETAL_ADRENAL_STROMAL_CELLS 6.69e-21 47.30 24.11 2.64e-19 4.49e-18
17COL1A1, COL3A1, LUM, POSTN, DCN, COL6A3, SULF1, COL12A1, CCDC80, PRRX1, MGP, THBS2, CDH11, SFRP2, ISLR, LOX, TAGLN
 153
TRAVAGLINI_LUNG_MYOFIBROBLAST_CELL 5.60e-14 56.66 24.06 1.63e-12 3.76e-11
10COL1A1, COL3A1, COMP, POSTN, COL12A1, VCAN, TNC, CTHRC1, MMP2, DPT
 65
DESCARTES_FETAL_STOMACH_STROMAL_CELLS 1.62e-11 56.55 21.62 4.18e-10 1.09e-08
8COL1A1, COL3A1, DCN, COL6A3, SFRP2, TAGLN, FBLN1, DPT
 50
GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS 4.17e-30 39.50 21.54 3.50e-28 2.80e-27
30COL1A1, COL3A1, COL1A2, LUM, SPARC, POSTN, DCN, COL6A3, COL5A2, COL5A1, COL6A2, SULF1, FBN1, BGN, COL12A1, AEBP1, FSTL1, CCDC80, VCAN, MGP, COL6A1, SERPINF1, CDH11, CCDC8, CRISPLD2, ISLR, LOX, FBLN1, MMP2, IGFBP7
 505
DESCARTES_FETAL_MUSCLE_STROMAL_CELLS 2.23e-15 45.82 21.07 7.13e-14 1.50e-12
12COL1A1, COL3A1, COL1A2, LUM, POSTN, DCN, COL12A1, MFAP5, MGP, ISLR, FBLN1, DPT
 98

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 9.53e-51 159.42 84.06 4.76e-49 4.76e-49
34COL1A1, COL3A1, COL1A2, LUM, SFRP4, COMP, SPARC, POSTN, FN1, LRRC15, DCN, COL6A3, COL5A2, COL5A1, COL6A2, FBN1, BGN, COL12A1, FSTL1, VCAN, MFAP5, TIMP1, TNC, PRRX1, MGP, IGFBP4, THBS2, CDH11, CTHRC1, LOX, TAGLN, COL11A1, FBLN1, MMP2
 200
HALLMARK_ANGIOGENESIS 7.72e-11 69.93 24.51 1.93e-09 3.86e-09
7COL3A1, LUM, POSTN, COL5A2, FSTL1, VCAN, TIMP1
 36
HALLMARK_COAGULATION 1.05e-06 15.53 5.78 1.31e-05 5.23e-05
7COMP, SPARC, FN1, FBN1, TIMP1, PRSS23, MMP2
 138
HALLMARK_MYOGENESIS 9.73e-07 12.40 4.96 1.31e-05 4.87e-05
8COL1A1, COL3A1, SPARC, COL6A3, COL6A2, AEBP1, TAGLN, IGFBP7
 200
HALLMARK_UV_RESPONSE_DN 2.46e-04 9.99 3.05 2.46e-03 1.23e-02
5COL1A1, COL3A1, COL1A2, COL5A2, COL11A1
 144
HALLMARK_APOPTOSIS 4.10e-04 8.90 2.72 3.42e-03 2.05e-02
5LUM, DCN, BGN, TIMP1, MMP2
 161
HALLMARK_HYPOXIA 7.71e-03 5.55 1.44 4.82e-02 3.85e-01
4DCN, COL5A1, BGN, LOX
 200
HALLMARK_APICAL_JUNCTION 7.71e-03 5.55 1.44 4.82e-02 3.85e-01
4FBN1, VCAN, CDH11, MMP2
 200
HALLMARK_GLYCOLYSIS 4.35e-02 4.05 0.80 2.42e-01 1.00e+00
3DCN, COL5A1, VCAN
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2IGFBP4, PRSS23
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2IGFBP4, PRSS23
 200
HALLMARK_COMPLEMENT 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2FN1, TIMP1
 200
HALLMARK_XENOBIOTIC_METABOLISM 1.85e-01 2.63 0.31 7.11e-01 1.00e+00
2IGFBP4, FBLN1
 200
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1COL6A1
 199
HALLMARK_TNFA_SIGNALING_VIA_NFKB 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1TNC
 200
HALLMARK_INFLAMMATORY_RESPONSE 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1TIMP1
 200
HALLMARK_ALLOGRAFT_REJECTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1TIMP1
 200
HALLMARK_KRAS_SIGNALING_UP 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1PRRX1
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_MITOTIC_SPINDLE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 199

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_ECM_RECEPTOR_INTERACTION 5.49e-18 61.70 28.84 1.02e-15 1.02e-15
13COL1A1, COL3A1, COL1A2, COMP, FN1, COL6A3, COL5A2, COL5A1, COL6A2, TNC, COL6A1, THBS2, COL11A1
 84
KEGG_FOCAL_ADHESION 4.72e-13 23.60 11.32 4.39e-11 8.77e-11
13COL1A1, COL3A1, COL1A2, COMP, FN1, COL6A3, COL5A2, COL5A1, COL6A2, TNC, COL6A1, THBS2, COL11A1
 199
KEGG_TGF_BETA_SIGNALING_PATHWAY 4.74e-03 9.61 1.88 2.94e-01 8.81e-01
3COMP, DCN, THBS2
 86
KEGG_WNT_SIGNALING_PATHWAY 1.19e-01 3.50 0.41 1.00e+00 1.00e+00
2SFRP4, SFRP2
 151
KEGG_PATHWAYS_IN_CANCER 3.61e-01 1.61 0.19 1.00e+00 1.00e+00
2FN1, MMP2
 325
KEGG_BLADDER_CANCER 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1MMP2
 42
KEGG_SMALL_CELL_LUNG_CANCER 2.84e-01 3.07 0.08 1.00e+00 1.00e+00
1FN1
 84
KEGG_GNRH_SIGNALING_PATHWAY 3.31e-01 2.55 0.06 1.00e+00 1.00e+00
1MMP2
 101
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 3.69e-01 2.22 0.05 1.00e+00 1.00e+00
1MMP2
 116
KEGG_CELL_ADHESION_MOLECULES_CAMS 4.10e-01 1.93 0.05 1.00e+00 1.00e+00
1VCAN
 133
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.70e-01 1.20 0.03 1.00e+00 1.00e+00
1FN1
 213
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_GLYCEROLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 49
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 25
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 77
KEGG_ETHER_LIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 33

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2q32 6.78e-02 4.91 0.57 1.00e+00 1.00e+00
2COL3A1, COL5A2
 108
chr1q24 8.47e-02 4.30 0.50 1.00e+00 1.00e+00
2PRRX1, DPT
 123
chr12q21 9.06e-02 4.13 0.48 1.00e+00 1.00e+00
2LUM, DCN
 128
chr3q13 1.67e-01 2.82 0.33 1.00e+00 1.00e+00
2FSTL1, CCDC80
 187
chr21q22 3.99e-01 1.48 0.17 1.00e+00 1.00e+00
2COL6A2, COL6A1
 353
chr3p13 1.47e-01 6.54 0.16 1.00e+00 1.00e+00
1GXYLT2
 40
chr3q12 1.67e-01 5.67 0.14 1.00e+00 1.00e+00
1COL8A1
 46
chr17q21 6.95e-01 1.14 0.13 1.00e+00 1.00e+00
2COL1A1, IGFBP4
 457
chr7p13 1.81e-01 5.21 0.13 1.00e+00 1.00e+00
1AEBP1
 50
chr8q13 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1SULF1
 71
chr16q21 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1CDH11
 74
chr6q27 2.58e-01 3.45 0.08 1.00e+00 1.00e+00
1THBS2
 75
chr13q13 2.67e-01 3.31 0.08 1.00e+00 1.00e+00
1POSTN
 78
chr4q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1IGFBP7
 79
chr6q14 3.09e-01 2.77 0.07 1.00e+00 1.00e+00
1COL12A1
 93
chr16q12 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1MMP2
 96
chr1p21 3.25e-01 2.60 0.06 1.00e+00 1.00e+00
1COL11A1
 99
chr12p12 3.46e-01 2.41 0.06 1.00e+00 1.00e+00
1MGP
 107
chr5q33 3.52e-01 2.36 0.06 1.00e+00 1.00e+00
1SPARC
 109
chr5q23 3.57e-01 2.32 0.06 1.00e+00 1.00e+00
1LOX
 111

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
YTAATTAA_LHX3_01 9.02e-04 7.43 2.27 1.27e-01 1.00e+00
5LRRC15, SULF1, COL12A1, PRRX1, BNC2
 192
AAANWWTGC_UNKNOWN 9.66e-04 7.31 2.24 1.27e-01 1.00e+00
5FN1, THBS2, SFRP2, BNC2, LOX
 195
TGGAAA_NFAT_Q4_01 5.35e-04 3.07 1.58 1.27e-01 6.06e-01
16COL1A2, SFRP4, FN1, DCN, SULF1, COL12A1, FSTL1, COL8A1, CCDC80, VCAN, PRRX1, MGP, CTHRC1, BNC2, LOX, IGFBP7
 1934
POU3F2_01 7.58e-03 8.06 1.58 3.57e-01 1.00e+00
3PRRX1, BNC2, LOX
 102
YAATNRNNNYNATT_UNKNOWN 7.99e-03 7.90 1.55 3.57e-01 1.00e+00
3SULF1, SERPINF1, BNC2
 104
TATAAA_TATA_01 2.05e-03 3.03 1.44 1.79e-01 1.00e+00
12COL1A1, COL1A2, POSTN, FN1, SULF1, COL8A1, MGP, IGFBP4, THBS2, CTHRC1, BNC2, DPT
 1317
MZF1_01 1.42e-02 4.61 1.19 3.96e-01 1.00e+00
4DCN, SULF1, PRRX1, ADAMTS12
 240
MEF2_03 1.42e-02 4.61 1.19 3.96e-01 1.00e+00
4COL8A1, PRRX1, THBS2, BNC2
 240
POU6F1_01 1.42e-02 4.61 1.19 3.96e-01 1.00e+00
4COL1A2, LRRC15, FSTL1, BNC2
 240
SRF_Q6 1.58e-02 4.45 1.16 3.96e-01 1.00e+00
4COL1A1, COL1A2, TAGLN, ADAMTS12
 248
NFAT_Q6 1.60e-02 4.44 1.15 3.96e-01 1.00e+00
4COL3A1, SULF1, COL8A1, BNC2
 249
MEF2_Q6_01 1.62e-02 4.42 1.15 3.96e-01 1.00e+00
4COL1A1, COL8A1, BNC2, ADAMTS12
 250
AP3_Q6 1.64e-02 4.40 1.14 3.96e-01 1.00e+00
4SPARC, FN1, SULF1, FSTL1
 251
CIZ_01 1.71e-02 4.35 1.13 3.96e-01 1.00e+00
4COL3A1, PRRX1, BNC2, MMP2
 254
OCT1_05 1.73e-02 4.33 1.12 3.96e-01 1.00e+00
4DCN, COL12A1, PRRX1, BNC2
 255
AACTTT_UNKNOWN 1.87e-02 2.30 1.12 3.96e-01 1.00e+00
13COL3A1, COL1A2, LUM, SPARC, POSTN, DCN, CCDC80, VCAN, PRRX1, CDH11, BNC2, LOX, MMP2
 1928
PITX2_Q2 1.93e-02 4.18 1.09 3.96e-01 1.00e+00
4LRRC15, SULF1, CDH11, BNC2
 264
POU3F2_02 1.96e-02 4.16 1.08 3.96e-01 1.00e+00
4DCN, CCDC80, SFRP2, LOX
 265
WGTTNNNNNAAA_UNKNOWN 1.82e-02 3.11 1.08 3.96e-01 1.00e+00
6DCN, COL12A1, VCAN, MGP, BNC2, MMP2
 554
CEBPB_02 1.98e-02 4.15 1.08 3.96e-01 1.00e+00
4SULF1, VCAN, SERPINF1, BNC2
 266

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_COLLAGEN_FIBRIL_ORGANIZATION 1.09e-20 106.41 48.41 4.07e-17 8.14e-17
13COL1A1, COL3A1, COL1A2, LUM, COMP, COL5A2, COL5A1, COL12A1, AEBP1, SFRP2, LOX, COL11A1, DPT
 54
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION 1.72e-38 66.89 35.85 1.29e-34 1.29e-34
33COL1A1, COL3A1, COL1A2, LUM, COMP, SPARC, POSTN, FN1, DCN, COL6A3, COL5A2, COL5A1, COL6A2, SULF1, FBN1, BGN, COL12A1, AEBP1, COL8A1, CCDC80, VCAN, MFAP5, TIMP1, TNC, COL6A1, SFRP2, CRISPLD2, LOX, COL11A1, FBLN1, ADAMTS12, MMP2, DPT
 396
GOBP_TENDON_DEVELOPMENT 2.06e-06 197.13 28.20 5.13e-04 1.54e-02
3COMP, COL5A1, COL11A1
 7
GOBP_ENDODERMAL_CELL_DIFFERENTIATION 5.46e-12 65.93 24.97 8.23e-09 4.09e-08
8FN1, COL5A2, COL5A1, COL12A1, COL8A1, COL6A1, COL11A1, MMP2
 44
GOBP_ENDODERM_FORMATION 2.64e-11 52.76 20.26 2.47e-08 1.98e-07
8FN1, COL5A2, COL5A1, COL12A1, COL8A1, COL6A1, COL11A1, MMP2
 53
GOBP_REGULATION_OF_ENDODERMAL_CELL_DIFFERENTIATION 1.54e-04 172.68 14.09 2.02e-02 1.00e+00
2COL5A2, COL5A1
 5
GOBP_ENDODERM_DEVELOPMENT 5.18e-10 34.96 13.66 3.82e-07 3.88e-06
8FN1, COL5A2, COL5A1, COL12A1, COL8A1, COL6A1, COL11A1, MMP2
 76
GOBP_DERMATAN_SULFATE_METABOLIC_PROCESS 1.65e-05 79.36 13.63 3.13e-03 1.23e-01
3DCN, BGN, VCAN
 13
GOBP_CHONDROITIN_SULFATE_CATABOLIC_PROCESS 2.09e-05 72.24 12.54 3.64e-03 1.57e-01
3DCN, BGN, VCAN
 14
GOBP_PEPTIDE_CROSS_LINKING_VIA_CHONDROITIN_4_SULFATE_GLYCOSAMINOGLYCAN 2.31e-04 129.66 11.45 2.70e-02 1.00e+00
2DCN, BGN
 6
GOBP_DIRECT_OSSIFICATION 2.31e-04 129.66 11.45 2.70e-02 1.00e+00
2COL1A1, MMP2
 6
GOBP_NEGATIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY 2.31e-04 129.66 11.45 2.70e-02 1.00e+00
2SFRP4, SFRP2
 6
GOBP_CHONDROCYTE_DEVELOPMENT 4.22e-06 45.22 10.96 9.28e-04 3.16e-02
4COMP, SULF1, SFRP2, COL11A1
 28
GOBP_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS 3.20e-05 61.17 10.83 5.21e-03 2.40e-01
3DCN, BGN, VCAN
 16
GOBP_FORMATION_OF_PRIMARY_GERM_LAYER 5.61e-10 25.85 10.78 3.82e-07 4.20e-06
9FN1, COL5A2, COL5A1, COL12A1, COL8A1, COL6A1, SFRP2, COL11A1, MMP2
 115
GOBP_SKELETAL_SYSTEM_DEVELOPMENT 2.95e-16 17.94 9.58 7.35e-13 2.20e-12
20COL1A1, COL3A1, COL1A2, LUM, SFRP4, COMP, COL5A2, SULF1, FBN1, BGN, VCAN, TIMP1, PRRX1, MGP, CDH11, SFRP2, LOX, COL11A1, ADAMTS12, MMP2
 485
GOBP_CARTILAGE_DEVELOPMENT 9.73e-11 20.37 9.25 8.09e-08 7.28e-07
11COL1A1, LUM, COMP, SULF1, BGN, TIMP1, PRRX1, MGP, SFRP2, COL11A1, ADAMTS12
 184
GOBP_CONNECTIVE_TISSUE_DEVELOPMENT 5.50e-12 19.18 9.22 8.23e-09 4.12e-08
13COL1A1, LUM, COMP, COL5A1, SULF1, BGN, TIMP1, PRRX1, MGP, SFRP2, LOX, COL11A1, ADAMTS12
 242
GOBP_PEPTIDE_CROSS_LINKING 1.05e-05 34.98 8.63 2.08e-03 7.89e-02
4COL3A1, FN1, DCN, BGN
 35
GOBP_BONE_TRABECULA_FORMATION 5.49e-04 74.10 7.33 5.41e-02 1.00e+00
2COL1A1, MMP2
 9

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE28737_BCL6_HET_VS_BCL6_KO_FOLLICULAR_BCELL_DN 9.73e-07 12.40 4.96 2.37e-03 4.74e-03
8COL1A1, COL1A2, SPARC, COL6A3, BGN, FSTL1, TNC, LOX
 200
GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN 9.73e-07 12.40 4.96 2.37e-03 4.74e-03
8COL1A2, DCN, COL5A2, FBN1, AEBP1, TNC, MGP, TAGLN
 200
GSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_24H_UP 1.15e-05 10.60 3.97 8.26e-03 5.60e-02
7COL1A1, SPARC, FSTL1, THBS2, CTHRC1, COL11A1, DPT
 199
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 1.19e-05 10.54 3.95 8.26e-03 5.79e-02
7COL1A2, COL6A3, BGN, TIMP1, MMP2, DPT, IGFBP7
 200
GSE8835_HEALTHY_VS_CLL_CD8_TCELL_DN 1.19e-05 10.54 3.95 8.26e-03 5.79e-02
7COL1A1, COL3A1, COL1A2, LUM, DCN, COL5A1, MMP2
 200
GSE4748_CTRL_VS_LPS_STIM_DC_3H_UP 1.19e-05 10.54 3.95 8.26e-03 5.79e-02
7COL3A1, POSTN, COL5A2, FBN1, FSTL1, CDH11, PRSS23
 200
GSE23505_IL6_IL1_IL23_VS_IL6_IL1_TGFB_TREATED_CD4_TCELL_UP 1.19e-05 10.54 3.95 8.26e-03 5.79e-02
7LUM, SFRP4, DCN, COL5A2, VCAN, MGP, MMP2
 200
GSE6259_CD4_TCELL_VS_CD8_TCELL_UP 8.59e-05 9.42 3.24 4.64e-02 4.19e-01
6FSTL1, TIMP1, SERPINF1, BNC2, TAGLN, FBLN1
 187
GSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_UP 1.17e-04 8.88 3.05 4.64e-02 5.71e-01
6FN1, COL6A3, VCAN, COL6A1, IGFBP4, THBS2
 198
GSE2405_0H_VS_1.5H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 1.24e-04 8.78 3.02 4.64e-02 6.03e-01
6COL3A1, COL1A2, SFRP4, CCDC80, MGP, TAGLN
 200
GSE3039_CD4_TCELL_VS_B2_BCELL_UP 1.24e-04 8.78 3.02 4.64e-02 6.03e-01
6FN1, BGN, FSTL1, TNC, IGFBP4, CDH11
 200
GSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_UP 1.24e-04 8.78 3.02 4.64e-02 6.03e-01
6COL3A1, LUM, DCN, COL5A2, TIMP1, COL6A1
 200
GSE43955_10H_VS_60H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN 1.24e-04 8.78 3.02 4.64e-02 6.03e-01
6COL1A1, COL1A2, AEBP1, MGP, THBS2, TAGLN
 200
GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_DN 5.24e-04 8.42 2.57 1.70e-01 1.00e+00
5COL1A1, DCN, COL5A2, FSTL1, ADAMTS12
 170
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN 6.12e-04 8.12 2.49 1.70e-01 1.00e+00
5SPARC, CCDC80, MGP, LOX, TAGLN
 176
GSE21546_UNSTIM_VS_ANTI_CD3_STIM_SAP1A_KO_DP_THYMOCYTES_UP 1.03e-03 7.19 2.20 1.70e-01 1.00e+00
5FN1, FSTL1, THBS2, PRSS23, TAGLN
 198
GSE1460_CD4_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN 1.06e-03 7.16 2.19 1.70e-01 1.00e+00
5COL1A1, LRRC15, COL6A2, MFAP5, BNC2
 199
GSE26488_WT_VS_HDAC7_DELTAP_TG_OT2_THYMOCYTE_WITH_PEPTIDE_INJECTION_DN 1.06e-03 7.16 2.19 1.70e-01 1.00e+00
5POSTN, COL6A2, BGN, FSTL1, PRSS23
 199
GSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN 1.06e-03 7.16 2.19 1.70e-01 1.00e+00
5SPARC, COL6A3, COL6A1, IGFBP4, THBS2
 199
GSE46606_UNSTIM_VS_CD40L_IL2_IL5_3DAY_STIMULATED_IRF4HIGH_SORTED_BCELL_DN 1.06e-03 7.16 2.19 1.70e-01 1.00e+00
5COL3A1, SFRP4, AEBP1, CDH11, BNC2
 199

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
SFRP4 5 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
FBN1 17 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
AEBP1 20 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).
PRRX1 28 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
BNC2 41 Yes Inferred motif Monomer or homomultimer In vivo/Misc source Has a putative AT-hook None
GLI3 61 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
LGR4 81 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SIX1 83 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
OSR2 85 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TBX15 97 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ID3 100 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
RUNX1 104 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
ZIC1 109 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NPAS2 119 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NRK 134 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a kinase
CREB3L1 139 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
VGLL3 141 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None (PMID: 23380592) describes this protein as a co-activator, and it doesnt seem to have a DBD (fig. 1)
NR1D1 144 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
WNT2 158 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
FZD4 159 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB14_CAGTCCTGTGAAAGAG-1 iPS_cells:adipose_stem_cells 0.18 1349.01
Raw ScoresOsteoblasts: 0.27, iPS_cells:adipose_stem_cells: 0.27, Chondrocytes:MSC-derived: 0.27, Fibroblasts:breast: 0.27, iPS_cells:PDB_fibroblasts: 0.26, iPS_cells:CRL2097_foreskin: 0.25, Tissue_stem_cells:BM_MSC: 0.25, Smooth_muscle_cells:vascular: 0.25, Smooth_muscle_cells:bronchial: 0.25, Tissue_stem_cells:BM_MSC:TGFb3: 0.25
NB14_AGTTGGTGTCGCTTCT-1 iPS_cells:adipose_stem_cells 0.17 1156.83
Raw ScoresChondrocytes:MSC-derived: 0.28, iPS_cells:adipose_stem_cells: 0.28, Osteoblasts: 0.28, Fibroblasts:breast: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.27, Tissue_stem_cells:BM_MSC: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, iPS_cells:CRL2097_foreskin: 0.26, Tissue_stem_cells:BM_MSC:osteogenic: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26
NB13_CTGATCCCATGGTTGT-1 Tissue_stem_cells:BM_MSC 0.09 570.62
Raw ScoresiPS_cells:CRL2097_foreskin: 0.28, Smooth_muscle_cells:bronchial: 0.28, iPS_cells:PDB_fibroblasts: 0.28, Chondrocytes:MSC-derived: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Osteoblasts: 0.27, iPS_cells:skin_fibroblast: 0.27, Fibroblasts:breast: 0.27, iPS_cells:fibroblasts: 0.27, iPS_cells:adipose_stem_cells: 0.27
NB12_ATGAGGGTCTGGTGTA-1 Fibroblasts:breast 0.20 491.82
Raw ScoresFibroblasts:breast: 0.27, iPS_cells:adipose_stem_cells: 0.26, Osteoblasts: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.25, Smooth_muscle_cells:vascular: 0.25, iPS_cells:CRL2097_foreskin: 0.25, Chondrocytes:MSC-derived: 0.25, Osteoblasts:BMP2: 0.25, Smooth_muscle_cells:vascular:IL-17: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.24
NB03_GCATGCGTCAGTTGAC-1 Osteoblasts 0.20 456.95
Raw ScoresFibroblasts:breast: 0.29, Osteoblasts: 0.29, iPS_cells:adipose_stem_cells: 0.29, Chondrocytes:MSC-derived: 0.28, iPS_cells:CRL2097_foreskin: 0.28, Tissue_stem_cells:BM_MSC: 0.27, Smooth_muscle_cells:vascular: 0.27, iPS_cells:PDB_fibroblasts: 0.27, Tissue_stem_cells:BM_MSC:osteogenic: 0.27, Smooth_muscle_cells:vascular:IL-17: 0.27
NB13_CCTTTCTAGCTAAACA-1 iPS_cells:adipose_stem_cells 0.18 456.65
Raw ScoresChondrocytes:MSC-derived: 0.26, Fibroblasts:breast: 0.25, iPS_cells:adipose_stem_cells: 0.25, Osteoblasts: 0.25, iPS_cells:CRL2097_foreskin: 0.24, iPS_cells:PDB_fibroblasts: 0.24, iPS_cells:fibroblasts: 0.24, Smooth_muscle_cells:bronchial: 0.23, Osteoblasts:BMP2: 0.23, iPS_cells:skin_fibroblast: 0.23
NB14_TCTGGAATCTGCCCTA-1 Fibroblasts:breast 0.11 394.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.17, MSC: 0.17, Fibroblasts:breast: 0.16, Chondrocytes:MSC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:CRL2097_foreskin: 0.16, iPS_cells:adipose_stem_cells: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Osteoblasts: 0.16
NB02_GTCTCGTCATACGCCG-1 Osteoblasts 0.22 387.87
Raw ScoresFibroblasts:breast: 0.33, Osteoblasts: 0.32, iPS_cells:adipose_stem_cells: 0.32, Chondrocytes:MSC-derived: 0.32, Tissue_stem_cells:BM_MSC: 0.31, Smooth_muscle_cells:vascular: 0.31, Smooth_muscle_cells:vascular:IL-17: 0.3, Tissue_stem_cells:BM_MSC:osteogenic: 0.3, Osteoblasts:BMP2: 0.3, Tissue_stem_cells:BM_MSC:TGFb3: 0.3
NB14_TCGAGGCTCGCCCTTA-1 iPS_cells:adipose_stem_cells 0.14 368.42
Raw ScoresChondrocytes:MSC-derived: 0.18, iPS_cells:adipose_stem_cells: 0.17, Osteoblasts: 0.17, Tissue_stem_cells:BM_MSC: 0.17, Fibroblasts:breast: 0.16, Smooth_muscle_cells:vascular: 0.16, Smooth_muscle_cells:vascular:IL-17: 0.16, Smooth_muscle_cells:bronchial: 0.16, Tissue_stem_cells:BM_MSC:osteogenic: 0.16, Smooth_muscle_cells:bronchial:vit_D: 0.16
NB14_ATAACGCCACGTCAGC-1 Tissue_stem_cells:BM_MSC 0.13 337.00
Raw ScoresChondrocytes:MSC-derived: 0.22, Fibroblasts:breast: 0.21, iPS_cells:adipose_stem_cells: 0.21, Smooth_muscle_cells:bronchial: 0.21, iPS_cells:CRL2097_foreskin: 0.21, Osteoblasts: 0.21, MSC: 0.2, Smooth_muscle_cells:bronchial:vit_D: 0.2, Smooth_muscle_cells:vascular: 0.2, Tissue_stem_cells:BM_MSC:BMP2: 0.2
NB02_TGGACGCTCAGGTAAA-1 Chondrocytes:MSC-derived 0.15 316.51
Raw ScoresOsteoblasts: 0.24, Chondrocytes:MSC-derived: 0.24, Fibroblasts:breast: 0.23, Tissue_stem_cells:BM_MSC:TGFb3: 0.23, Smooth_muscle_cells:vascular: 0.23, iPS_cells:adipose_stem_cells: 0.23, Tissue_stem_cells:BM_MSC: 0.23, Tissue_stem_cells:BM_MSC:BMP2: 0.23, Smooth_muscle_cells:vascular:IL-17: 0.22, iPS_cells:CRL2097_foreskin: 0.22
NB14_ACTTACTAGGATGTAT-1 Chondrocytes:MSC-derived 0.13 305.95
Raw ScoresChondrocytes:MSC-derived: 0.15, Tissue_stem_cells:BM_MSC: 0.15, Fibroblasts:breast: 0.14, MSC: 0.14, Osteoblasts: 0.14, Smooth_muscle_cells:vascular: 0.14, Tissue_stem_cells:BM_MSC:osteogenic: 0.14, iPS_cells:adipose_stem_cells: 0.14, Smooth_muscle_cells:vascular:IL-17: 0.13, iPS_cells:PDB_fibroblasts: 0.13
NB13_TTAGGACAGAGAGCTC-1 iPS_cells:adipose_stem_cells 0.14 293.55
Raw ScoresiPS_cells:adipose_stem_cells: 0.26, Fibroblasts:breast: 0.26, Smooth_muscle_cells:vascular: 0.25, iPS_cells:CRL2097_foreskin: 0.25, Chondrocytes:MSC-derived: 0.25, Smooth_muscle_cells:bronchial: 0.25, Smooth_muscle_cells:vascular:IL-17: 0.25, Tissue_stem_cells:BM_MSC: 0.25, Osteoblasts: 0.25, Osteoblasts:BMP2: 0.25
NB13_CATCGGGAGATGAGAG-1 iPS_cells:adipose_stem_cells 0.10 283.18
Raw ScoresiPS_cells:CRL2097_foreskin: 0.25, iPS_cells:adipose_stem_cells: 0.25, Fibroblasts:breast: 0.25, Osteoblasts: 0.24, Smooth_muscle_cells:bronchial: 0.24, iPS_cells:skin_fibroblast: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.24, iPS_cells:PDB_fibroblasts: 0.24, iPS_cells:fibroblasts: 0.24, Tissue_stem_cells:BM_MSC:TGFb3: 0.24
NB14_CGTGTAATCGGTTCGG-1 Chondrocytes:MSC-derived 0.15 270.93
Raw ScoresChondrocytes:MSC-derived: 0.2, Osteoblasts: 0.2, Fibroblasts:breast: 0.19, iPS_cells:adipose_stem_cells: 0.18, Tissue_stem_cells:BM_MSC:TGFb3: 0.18, Tissue_stem_cells:BM_MSC:osteogenic: 0.18, Smooth_muscle_cells:bronchial: 0.18, Tissue_stem_cells:BM_MSC: 0.18, Tissue_stem_cells:BM_MSC:BMP2: 0.18, Smooth_muscle_cells:bronchial:vit_D: 0.18
NB13_ATCATCTGTCGCGTGT-1 Smooth_muscle_cells:vascular 0.16 267.89
Raw ScoresSmooth_muscle_cells:bronchial: 0.22, Fibroblasts:breast: 0.22, Smooth_muscle_cells:bronchial:vit_D: 0.22, Smooth_muscle_cells:vascular: 0.21, iPS_cells:adipose_stem_cells: 0.21, Smooth_muscle_cells:vascular:IL-17: 0.21, Osteoblasts: 0.2, iPS_cells:CRL2097_foreskin: 0.2, Osteoblasts:BMP2: 0.2, Tissue_stem_cells:BM_MSC:BMP2: 0.2
NB02_AGCGGTCCAGATCTGT-1 Fibroblasts:breast 0.20 258.06
Raw ScoresFibroblasts:breast: 0.31, iPS_cells:adipose_stem_cells: 0.3, Smooth_muscle_cells:vascular:IL-17: 0.3, Smooth_muscle_cells:vascular: 0.3, Osteoblasts: 0.29, Chondrocytes:MSC-derived: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Smooth_muscle_cells:bronchial: 0.28, iPS_cells:CRL2097_foreskin: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28
NB13_TTCTACATCCAGAAGG-1 iPS_cells:adipose_stem_cells 0.16 249.88
Raw ScoresFibroblasts:breast: 0.22, Osteoblasts: 0.22, iPS_cells:adipose_stem_cells: 0.22, iPS_cells:CRL2097_foreskin: 0.22, Smooth_muscle_cells:vascular: 0.22, Chondrocytes:MSC-derived: 0.21, Osteoblasts:BMP2: 0.21, Smooth_muscle_cells:bronchial: 0.21, Smooth_muscle_cells:bronchial:vit_D: 0.21, Smooth_muscle_cells:vascular:IL-17: 0.21
NB01_TACACGACAGATCTGT-1 iPS_cells:CRL2097_foreskin 0.12 240.27
Raw ScoresSmooth_muscle_cells:bronchial: 0.19, Smooth_muscle_cells:bronchial:vit_D: 0.19, iPS_cells:CRL2097_foreskin: 0.19, MSC: 0.19, Tissue_stem_cells:BM_MSC:TGFb3: 0.19, Chondrocytes:MSC-derived: 0.18, Tissue_stem_cells:BM_MSC:BMP2: 0.18, iPS_cells:skin_fibroblast: 0.18, Fibroblasts:breast: 0.18, Fibroblasts:foreskin: 0.18
NB02_CCCTCCTGTAGGGACT-1 Fibroblasts:breast 0.18 225.92
Raw ScoresFibroblasts:breast: 0.28, Osteoblasts: 0.28, iPS_cells:adipose_stem_cells: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Smooth_muscle_cells:bronchial: 0.27, Chondrocytes:MSC-derived: 0.27, iPS_cells:CRL2097_foreskin: 0.27, Smooth_muscle_cells:vascular: 0.27, Smooth_muscle_cells:vascular:IL-17: 0.26, Tissue_stem_cells:BM_MSC: 0.26
NB02_GATCAGTAGAAGGCCT-1 Tissue_stem_cells:BM_MSC 0.13 203.44
Raw ScoresOsteoblasts: 0.2, Fibroblasts:breast: 0.2, Chondrocytes:MSC-derived: 0.2, Tissue_stem_cells:BM_MSC: 0.2, Tissue_stem_cells:BM_MSC:BMP2: 0.2, Smooth_muscle_cells:vascular:IL-17: 0.19, iPS_cells:adipose_stem_cells: 0.19, Tissue_stem_cells:BM_MSC:osteogenic: 0.19, Smooth_muscle_cells:vascular: 0.19, Osteoblasts:BMP2: 0.19
NB13_GCGCGATCATATGGTC-1 iPS_cells:CRL2097_foreskin 0.11 201.99
Raw ScoresiPS_cells:CRL2097_foreskin: 0.19, iPS_cells:skin_fibroblast: 0.18, Neurons:adrenal_medulla_cell_line: 0.18, Fibroblasts:breast: 0.18, Smooth_muscle_cells:bronchial: 0.18, Smooth_muscle_cells:bronchial:vit_D: 0.18, Osteoblasts: 0.18, iPS_cells:PDB_fibroblasts: 0.18, iPS_cells:adipose_stem_cells: 0.18, iPS_cells:fibroblasts: 0.18
NB14_GGCCGATGTCCGCTGA-1 Tissue_stem_cells:BM_MSC 0.15 196.79
Raw ScoresOsteoblasts: 0.2, Smooth_muscle_cells:bronchial: 0.2, Chondrocytes:MSC-derived: 0.2, Smooth_muscle_cells:bronchial:vit_D: 0.2, iPS_cells:adipose_stem_cells: 0.19, Osteoblasts:BMP2: 0.19, iPS_cells:CRL2097_foreskin: 0.19, Tissue_stem_cells:BM_MSC: 0.19, Fibroblasts:breast: 0.19, Smooth_muscle_cells:vascular: 0.19
NB02_TGGCTGGGTCCATCCT-1 Fibroblasts:breast 0.18 193.41
Raw ScoresFibroblasts:breast: 0.24, iPS_cells:adipose_stem_cells: 0.23, Osteoblasts: 0.23, Tissue_stem_cells:BM_MSC: 0.22, Smooth_muscle_cells:vascular: 0.22, Smooth_muscle_cells:vascular:IL-17: 0.21, iPS_cells:CRL2097_foreskin: 0.21, Chondrocytes:MSC-derived: 0.21, Tissue_stem_cells:BM_MSC:osteogenic: 0.21, Osteoblasts:BMP2: 0.21
NB13_GGACAGAAGGAATCGC-1 Fibroblasts:breast 0.15 188.59
Raw ScoresSmooth_muscle_cells:bronchial: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.24, Osteoblasts: 0.24, iPS_cells:adipose_stem_cells: 0.24, Smooth_muscle_cells:vascular: 0.24, Chondrocytes:MSC-derived: 0.23, Tissue_stem_cells:BM_MSC:TGFb3: 0.23, Fibroblasts:breast: 0.23, Smooth_muscle_cells:vascular:IL-17: 0.23, Tissue_stem_cells:BM_MSC:BMP2: 0.23
NB14_AATCCAGTCATAAAGG-1 Neurons:adrenal_medulla_cell_line 0.10 182.03
Raw ScoresFibroblasts:breast: 0.15, Neurons:adrenal_medulla_cell_line: 0.15, Smooth_muscle_cells:bronchial: 0.15, Smooth_muscle_cells:bronchial:vit_D: 0.15, Fibroblasts:foreskin: 0.14, MSC: 0.14, iPS_cells:skin_fibroblast: 0.14, iPS_cells:adipose_stem_cells: 0.14, iPS_cells:CRL2097_foreskin: 0.14, Tissue_stem_cells:BM_MSC: 0.14
NB14_TTTCCTCCACAACGCC-1 Fibroblasts:breast 0.09 181.52
Raw ScoresChondrocytes:MSC-derived: 0.13, Fibroblasts:breast: 0.12, iPS_cells:adipose_stem_cells: 0.12, Smooth_muscle_cells:bronchial: 0.12, Osteoblasts: 0.12, Smooth_muscle_cells:bronchial:vit_D: 0.12, iPS_cells:CRL2097_foreskin: 0.12, iPS_cells:PDB_fibroblasts: 0.11, iPS_cells:skin_fibroblast: 0.11, Smooth_muscle_cells:vascular: 0.11
NB14_TTTACTGCATCAGTAC-1 Tissue_stem_cells:BM_MSC 0.14 169.78
Raw ScoresiPS_cells:adipose_stem_cells: 0.17, Fibroblasts:breast: 0.17, Osteoblasts: 0.17, iPS_cells:CRL2097_foreskin: 0.16, Chondrocytes:MSC-derived: 0.16, Tissue_stem_cells:BM_MSC: 0.16, iPS_cells:PDB_fibroblasts: 0.16, Smooth_muscle_cells:bronchial: 0.16, Smooth_muscle_cells:vascular: 0.16, MSC: 0.16
NB13_CTAGCCTGTCGGATCC-1 iPS_cells:adipose_stem_cells 0.14 167.54
Raw ScoresiPS_cells:adipose_stem_cells: 0.2, Chondrocytes:MSC-derived: 0.2, Fibroblasts:breast: 0.19, Osteoblasts: 0.19, Tissue_stem_cells:BM_MSC:TGFb3: 0.19, Tissue_stem_cells:BM_MSC: 0.19, Tissue_stem_cells:BM_MSC:BMP2: 0.19, Tissue_stem_cells:BM_MSC:osteogenic: 0.18, Smooth_muscle_cells:vascular: 0.18, Smooth_muscle_cells:vascular:IL-17: 0.18
NB11_TCTTCGGGTGGTCCGT-1 iPS_cells:adipose_stem_cells 0.18 165.34
Raw ScoresiPS_cells:adipose_stem_cells: 0.23, Fibroblasts:breast: 0.23, iPS_cells:CRL2097_foreskin: 0.22, Osteoblasts: 0.21, Smooth_muscle_cells:bronchial: 0.21, Smooth_muscle_cells:vascular: 0.21, Chondrocytes:MSC-derived: 0.21, Osteoblasts:BMP2: 0.21, Tissue_stem_cells:BM_MSC: 0.21, Smooth_muscle_cells:bronchial:vit_D: 0.21
NB13_GCACTCTGTTGTTTGG-1 iPS_cells:adipose_stem_cells 0.11 164.84
Raw ScoresiPS_cells:adipose_stem_cells: 0.2, Fibroblasts:breast: 0.19, Smooth_muscle_cells:vascular: 0.19, Smooth_muscle_cells:bronchial: 0.19, Chondrocytes:MSC-derived: 0.19, Osteoblasts: 0.19, Tissue_stem_cells:BM_MSC:TGFb3: 0.19, Smooth_muscle_cells:vascular:IL-17: 0.19, Smooth_muscle_cells:bronchial:vit_D: 0.19, Tissue_stem_cells:BM_MSC: 0.19
NB13_CGTTCTGGTGCGAAAC-1 Fibroblasts:breast 0.15 158.63
Raw ScoresSmooth_muscle_cells:vascular: 0.22, Fibroblasts:breast: 0.22, iPS_cells:CRL2097_foreskin: 0.21, iPS_cells:adipose_stem_cells: 0.21, Tissue_stem_cells:BM_MSC: 0.21, Osteoblasts: 0.21, Smooth_muscle_cells:vascular:IL-17: 0.21, Smooth_muscle_cells:bronchial: 0.2, Smooth_muscle_cells:bronchial:vit_D: 0.2, Tissue_stem_cells:BM_MSC:osteogenic: 0.2
NB13_TCACGAATCTGACCTC-1 Fibroblasts:breast 0.13 152.95
Raw ScoresSmooth_muscle_cells:bronchial: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.23, Fibroblasts:breast: 0.23, Smooth_muscle_cells:vascular: 0.22, iPS_cells:adipose_stem_cells: 0.22, iPS_cells:CRL2097_foreskin: 0.22, Osteoblasts: 0.22, Osteoblasts:BMP2: 0.21, Smooth_muscle_cells:vascular:IL-17: 0.21, Chondrocytes:MSC-derived: 0.21
NB14_ACCTTTAGTCACCCAG-1 Neurons:adrenal_medulla_cell_line 0.08 150.98
Raw ScoresSmooth_muscle_cells:bronchial:vit_D: 0.12, Smooth_muscle_cells:bronchial: 0.12, Neurons:adrenal_medulla_cell_line: 0.12, iPS_cells:CRL2097_foreskin-derived:d20_hepatic_diff: 0.12, Fibroblasts:breast: 0.12, MSC: 0.12, Smooth_muscle_cells:vascular:IL-17: 0.12, Tissue_stem_cells:BM_MSC:BMP2: 0.12, Tissue_stem_cells:BM_MSC: 0.12, Chondrocytes:MSC-derived: 0.12
NB13_GAATAAGTCAGTTCGA-1 Smooth_muscle_cells:vascular 0.07 138.10
Raw ScoresiPS_cells:adipose_stem_cells: 0.17, Smooth_muscle_cells:vascular: 0.16, Fibroblasts:breast: 0.16, iPS_cells:CRL2097_foreskin: 0.16, iPS_cells:PDB_fibroblasts: 0.16, Smooth_muscle_cells:vascular:IL-17: 0.16, Chondrocytes:MSC-derived: 0.16, Osteoblasts: 0.15, Tissue_stem_cells:BM_MSC: 0.15, Osteoblasts:BMP2: 0.15
NB14_TAAGTGCCACGGATAG-1 Osteoblasts 0.09 137.97
Raw ScoresOsteoblasts: 0.14, Tissue_stem_cells:BM_MSC: 0.13, Chondrocytes:MSC-derived: 0.13, Tissue_stem_cells:BM_MSC:osteogenic: 0.13, Fibroblasts:breast: 0.13, iPS_cells:adipose_stem_cells: 0.13, iPS_cells:PDB_fibroblasts: 0.13, iPS_cells:skin_fibroblast: 0.13, Neurons:Schwann_cell: 0.12, iPS_cells:CRL2097_foreskin: 0.12
NB13_CTGCTGTAGTACCGGA-1 Fibroblasts:breast 0.14 132.48
Raw ScoresiPS_cells:adipose_stem_cells: 0.22, Fibroblasts:breast: 0.22, Osteoblasts: 0.22, Smooth_muscle_cells:bronchial: 0.22, iPS_cells:CRL2097_foreskin: 0.21, Smooth_muscle_cells:vascular: 0.21, Smooth_muscle_cells:bronchial:vit_D: 0.21, Chondrocytes:MSC-derived: 0.21, Tissue_stem_cells:BM_MSC:TGFb3: 0.21, Smooth_muscle_cells:vascular:IL-17: 0.2
NB02_CGTGTAATCTGCTGTC-1 Smooth_muscle_cells:vascular 0.13 132.31
Raw ScoresChondrocytes:MSC-derived: 0.18, Osteoblasts: 0.18, Smooth_muscle_cells:vascular: 0.18, Fibroblasts:breast: 0.18, Tissue_stem_cells:BM_MSC:BMP2: 0.17, Smooth_muscle_cells:vascular:IL-17: 0.17, Tissue_stem_cells:BM_MSC:TGFb3: 0.17, Tissue_stem_cells:BM_MSC: 0.17, Smooth_muscle_cells:bronchial: 0.17, Tissue_stem_cells:BM_MSC:osteogenic: 0.17
NB05_CACATTTGTTTCGCTC-1 Fibroblasts:breast 0.15 131.28
Raw ScoresFibroblasts:breast: 0.18, iPS_cells:adipose_stem_cells: 0.18, Smooth_muscle_cells:bronchial: 0.17, Smooth_muscle_cells:vascular: 0.17, Smooth_muscle_cells:bronchial:vit_D: 0.17, Smooth_muscle_cells:vascular:IL-17: 0.17, iPS_cells:CRL2097_foreskin: 0.17, Osteoblasts: 0.16, iPS_cells:PDB_fibroblasts: 0.16, Chondrocytes:MSC-derived: 0.15
NB14_GTACTCCAGCCCGAAA-1 Tissue_stem_cells:BM_MSC 0.13 130.72
Raw ScoresTissue_stem_cells:BM_MSC: 0.19, Osteoblasts: 0.19, Smooth_muscle_cells:vascular: 0.19, iPS_cells:adipose_stem_cells: 0.19, Fibroblasts:breast: 0.19, Chondrocytes:MSC-derived: 0.19, Smooth_muscle_cells:vascular:IL-17: 0.18, Smooth_muscle_cells:bronchial: 0.18, Smooth_muscle_cells:bronchial:vit_D: 0.18, iPS_cells:CRL2097_foreskin: 0.18
NB14_TGCCAAAGTGATAAAC-1 Smooth_muscle_cells:vascular 0.08 129.12
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.13, Smooth_muscle_cells:bronchial: 0.12, iPS_cells:PDB_fibroblasts: 0.12, Smooth_muscle_cells:bronchial:vit_D: 0.12, iPS_cells:skin_fibroblast: 0.12, MSC: 0.11, iPS_cells:CRL2097_foreskin: 0.11, iPS_cells:fibroblasts: 0.11, Fibroblasts:breast: 0.11, Neuroepithelial_cell:ESC-derived: 0.11
NB02_TAAGAGACACGCGAAA-1 Fibroblasts:breast 0.12 128.81
Raw ScoresOsteoblasts: 0.2, Tissue_stem_cells:BM_MSC: 0.19, Fibroblasts:breast: 0.19, Chondrocytes:MSC-derived: 0.19, Tissue_stem_cells:BM_MSC:TGFb3: 0.19, Tissue_stem_cells:BM_MSC:osteogenic: 0.19, iPS_cells:adipose_stem_cells: 0.19, Osteoblasts:BMP2: 0.19, Tissue_stem_cells:BM_MSC:BMP2: 0.18, Smooth_muscle_cells:vascular:IL-17: 0.18
NB11_CCCTCCTTCTCGCATC-1 iPS_cells:adipose_stem_cells 0.15 124.64
Raw ScoresiPS_cells:CRL2097_foreskin: 0.19, Fibroblasts:breast: 0.18, iPS_cells:adipose_stem_cells: 0.18, MSC: 0.18, Smooth_muscle_cells:bronchial: 0.18, Osteoblasts: 0.18, iPS_cells:PDB_fibroblasts: 0.18, iPS_cells:skin_fibroblast: 0.17, Smooth_muscle_cells:bronchial:vit_D: 0.17, Chondrocytes:MSC-derived: 0.17
NB02_AACTTTCCACTGAAGG-1 Osteoblasts 0.14 124.39
Raw ScoresOsteoblasts: 0.18, Chondrocytes:MSC-derived: 0.18, Osteoblasts:BMP2: 0.18, Fibroblasts:breast: 0.18, Smooth_muscle_cells:vascular: 0.17, iPS_cells:adipose_stem_cells: 0.17, Tissue_stem_cells:BM_MSC: 0.17, Tissue_stem_cells:BM_MSC:TGFb3: 0.17, Smooth_muscle_cells:vascular:IL-17: 0.17, Tissue_stem_cells:BM_MSC:BMP2: 0.16
NB13_GTACGTACAATCAGAA-1 Fibroblasts:breast 0.09 121.86
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Fibroblasts:breast: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, iPS_cells:adipose_stem_cells: 0.2, Neuroepithelial_cell:ESC-derived: 0.2, Osteoblasts: 0.19, iPS_cells:CRL2097_foreskin: 0.19, MSC: 0.19, iPS_cells:PDB_fibroblasts: 0.19, Smooth_muscle_cells:bronchial: 0.19
NB02_GTGCAGCGTACCCAAT-1 Tissue_stem_cells:BM_MSC 0.14 121.59
Raw ScoresSmooth_muscle_cells:vascular: 0.23, Smooth_muscle_cells:vascular:IL-17: 0.23, Fibroblasts:breast: 0.23, iPS_cells:adipose_stem_cells: 0.23, Tissue_stem_cells:BM_MSC:BMP2: 0.23, Tissue_stem_cells:BM_MSC: 0.23, Osteoblasts: 0.23, Osteoblasts:BMP2: 0.22, Tissue_stem_cells:BM_MSC:TGFb3: 0.22, Smooth_muscle_cells:bronchial: 0.22
NB14_AACTCCCGTTCACCTC-1 Fibroblasts:breast 0.07 121.02
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, MSC: 0.14, Neurons:Schwann_cell: 0.14, Fibroblasts:foreskin: 0.13, Fibroblasts:breast: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:CRL2097_foreskin: 0.13, iPS_cells:skin_fibroblast: 0.13
NB05_GAGCAGAGTATCTGCA-1 Fibroblasts:breast 0.11 119.84
Raw ScoresFibroblasts:breast: 0.17, iPS_cells:adipose_stem_cells: 0.16, Chondrocytes:MSC-derived: 0.16, MSC: 0.16, iPS_cells:CRL2097_foreskin: 0.16, Tissue_stem_cells:BM_MSC:TGFb3: 0.15, Osteoblasts: 0.15, Smooth_muscle_cells:vascular:IL-17: 0.15, Smooth_muscle_cells:vascular: 0.15, Osteoblasts:BMP2: 0.15
NB13_ACTGAACTCGTCCGTT-1 Fibroblasts:breast 0.11 119.61
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, iPS_cells:CRL2097_foreskin: 0.17, Neuroepithelial_cell:ESC-derived: 0.17, iPS_cells:PDB_fibroblasts: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, iPS_cells:skin_fibroblast: 0.17, Smooth_muscle_cells:bronchial: 0.17, Fibroblasts:breast: 0.17, MSC: 0.17, iPS_cells:fibroblasts: 0.16
NB05_CGATTGACACATTAGC-1 Fibroblasts:breast 0.15 114.56
Raw ScoresFibroblasts:breast: 0.18, iPS_cells:adipose_stem_cells: 0.17, Osteoblasts: 0.16, Chondrocytes:MSC-derived: 0.16, Smooth_muscle_cells:bronchial: 0.16, Smooth_muscle_cells:vascular: 0.16, Osteoblasts:BMP2: 0.16, iPS_cells:CRL2097_foreskin: 0.15, Smooth_muscle_cells:vascular:IL-17: 0.15, Tissue_stem_cells:BM_MSC: 0.15


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.63e-20
Mean rank of genes in gene set: 1544.51
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A1 0.0310094 1 GTEx DepMap Descartes 12.50 4506.94
COL3A1 0.0253399 2 GTEx DepMap Descartes 9.04 3626.58
COL1A2 0.0241917 3 GTEx DepMap Descartes 15.10 6019.95
LUM 0.0169930 4 GTEx DepMap Descartes 1.45 1247.53
POSTN 0.0154492 8 GTEx DepMap Descartes 2.22 1299.99
FN1 0.0152264 9 GTEx DepMap Descartes 6.08 1259.02
DCN 0.0121242 11 GTEx DepMap Descartes 1.03 340.72
COL5A2 0.0101766 13 GTEx DepMap Descartes 2.70 846.73
COL5A1 0.0100927 14 GTEx DepMap Descartes 1.25 320.84
BGN 0.0090765 18 GTEx DepMap Descartes 1.24 1260.80
COL12A1 0.0088718 19 GTEx DepMap Descartes 1.27 243.95
COL8A1 0.0072234 22 GTEx DepMap Descartes 1.42 562.05
VCAN 0.0063658 24 GTEx DepMap Descartes 2.01 319.34
TNC 0.0059465 27 GTEx DepMap Descartes 0.86 207.24
THBS2 0.0051111 33 GTEx DepMap Descartes 1.75 690.25
TAGLN 0.0046021 44 GTEx DepMap Descartes 0.69 337.72
COL11A1 0.0045260 45 GTEx DepMap Descartes 0.63 173.00
MMP2 0.0043308 48 GTEx DepMap Descartes 0.84 577.86
IGFBP7 0.0041212 50 GTEx DepMap Descartes 2.70 3260.98
COL15A1 0.0034346 71 GTEx DepMap Descartes 0.24 76.41
COL4A1 0.0027095 102 GTEx DepMap Descartes 0.57 143.81
IGFBP3 0.0024808 111 GTEx DepMap Descartes 0.28 141.65
TMEM119 0.0024377 115 GTEx DepMap Descartes 0.13 101.96
ACTA2 0.0024096 121 GTEx DepMap Descartes 0.43 520.18
TPM1 0.0023193 129 GTEx DepMap Descartes 1.05 465.32
COL10A1 0.0021739 138 GTEx DepMap Descartes 0.08 64.32
THY1 0.0021164 149 GTEx DepMap Descartes 0.46 195.39
CNN2 0.0018522 169 GTEx DepMap Descartes 0.18 148.95
MYL9 0.0017234 181 GTEx DepMap Descartes 0.55 388.41
COL14A1 0.0016559 196 GTEx DepMap Descartes 0.60 206.16
MMP11 0.0013594 237 GTEx DepMap Descartes 0.03 18.25
TPM2 0.0013557 239 GTEx DepMap Descartes 0.63 834.54
THBS1 0.0010776 321 GTEx DepMap Descartes 2.26 608.54
TGFBR2 0.0010091 343 GTEx DepMap Descartes 0.34 99.94
CNN3 0.0007101 515 GTEx DepMap Descartes 0.37 375.15
TGFB2 0.0005571 682 GTEx DepMap Descartes 0.08 30.98
MYLK 0.0004794 811 GTEx DepMap Descartes 0.21 46.48
TGFB1 0.0003713 1080 GTEx DepMap Descartes 0.17 118.44
HOPX 0.0003589 1117 GTEx DepMap Descartes 0.02 9.10
PGF 0.0003381 1189 GTEx DepMap Descartes 0.11 46.03
ITGA7 0.0001981 2022 GTEx DepMap Descartes 0.05 15.24
COL13A1 0.0001547 2463 GTEx DepMap Descartes 0.03 16.86
TGFBR1 0.0000830 3482 GTEx DepMap Descartes 0.34 108.61
WNT5A -0.0000071 5544 GTEx DepMap Descartes 0.02 2.62
MYH11 -0.0000501 6871 GTEx DepMap Descartes 0.09 24.07
ACTG2 -0.0001750 10323 GTEx DepMap Descartes 0.02 20.22
VEGFA -0.0002838 11735 GTEx DepMap Descartes 0.18 30.81
MEF2C -0.0004565 12350 GTEx DepMap Descartes 0.28 39.27
RGS5 -0.0006491 12480 GTEx DepMap Descartes 0.27 65.98


Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.66e-10
Mean rank of genes in gene set: 89.77
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A1 0.0310094 1 GTEx DepMap Descartes 12.50 4506.94
COL3A1 0.0253399 2 GTEx DepMap Descartes 9.04 3626.58
COL1A2 0.0241917 3 GTEx DepMap Descartes 15.10 6019.95
LUM 0.0169930 4 GTEx DepMap Descartes 1.45 1247.53
SPARC 0.0157295 7 GTEx DepMap Descartes 4.67 2862.77
DCN 0.0121242 11 GTEx DepMap Descartes 1.03 340.72
COL6A2 0.0097484 15 GTEx DepMap Descartes 2.18 1226.54
BGN 0.0090765 18 GTEx DepMap Descartes 1.24 1260.80
PRRX1 0.0058900 28 GTEx DepMap Descartes 0.69 406.64
MGP 0.0058735 29 GTEx DepMap Descartes 1.57 1945.74
CALD1 0.0030436 87 GTEx DepMap Descartes 3.40 1270.49
PDGFRA 0.0018956 166 GTEx DepMap Descartes 0.21 107.46
LEPR 0.0004884 796 GTEx DepMap Descartes 0.12 29.71


Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e-08
Mean rank of genes in gene set: 409.17
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
POSTN 0.0154492 8 GTEx DepMap Descartes 2.22 1299.99
COL5A2 0.0101766 13 GTEx DepMap Descartes 2.70 846.73
FBN1 0.0092829 17 GTEx DepMap Descartes 1.49 251.75
FSTL1 0.0082068 21 GTEx DepMap Descartes 1.18 455.96
GSN 0.0039489 54 GTEx DepMap Descartes 0.62 179.81
IGFBP5 0.0038836 55 GTEx DepMap Descartes 0.44 133.96
COL14A1 0.0016559 196 GTEx DepMap Descartes 0.60 206.16
GAS1 0.0012877 254 GTEx DepMap Descartes 0.11 92.07
FBN2 0.0008658 401 GTEx DepMap Descartes 0.04 4.81
PENK 0.0005789 649 GTEx DepMap Descartes 0.02 53.67
SFRP1 0.0002710 1489 GTEx DepMap Descartes 0.15 68.87
ITM2A 0.0002337 1753 GTEx DepMap Descartes 0.02 29.59




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9434.91
Median rank of genes in gene set: 10556
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLIT3 0.0008905 385 GTEx DepMap Descartes 1.63 293.60
RNF144A 0.0007404 492 GTEx DepMap Descartes 0.40 153.06
CELF2 0.0005762 654 GTEx DepMap Descartes 0.61 146.78
HK2 0.0003342 1203 GTEx DepMap Descartes 0.00 0.00
IGSF3 0.0003083 1312 GTEx DepMap Descartes 0.07 9.03
DPYSL3 0.0002735 1482 GTEx DepMap Descartes 1.08 393.05
ICA1 0.0002118 1903 GTEx DepMap Descartes 1.66 982.97
NPTX2 0.0001919 2069 GTEx DepMap Descartes 0.06 39.47
RFC4 0.0001792 2181 GTEx DepMap Descartes 0.05 34.08
CDC42EP3 0.0001608 2382 GTEx DepMap Descartes 0.10 40.67
NELFCD 0.0001488 2543 GTEx DepMap Descartes 0.18 NA
HEY1 0.0001334 2722 GTEx DepMap Descartes 0.02 17.22
ABLIM1 0.0001118 3002 GTEx DepMap Descartes 0.17 30.97
SETD7 0.0001042 3113 GTEx DepMap Descartes 0.07 13.30
NET1 0.0000995 3187 GTEx DepMap Descartes 0.06 32.23
MYRIP 0.0000970 3232 GTEx DepMap Descartes 0.11 53.50
FAM107B 0.0000921 3319 GTEx DepMap Descartes 0.18 67.19
ZWILCH 0.0000884 3382 GTEx DepMap Descartes 0.05 34.68
IRS2 0.0000861 3425 GTEx DepMap Descartes 0.19 42.92
ANP32A 0.0000813 3513 GTEx DepMap Descartes 0.21 110.84
PBK 0.0000770 3588 GTEx DepMap Descartes 0.05 26.70
CYGB 0.0000718 3697 GTEx DepMap Descartes 0.16 134.89
MSH6 0.0000577 3951 GTEx DepMap Descartes 0.04 9.92
RPS6KA2 0.0000452 4219 GTEx DepMap Descartes 0.27 64.70
BMP7 0.0000431 4265 GTEx DepMap Descartes 0.04 13.90
PPP2R3C 0.0000389 4355 GTEx DepMap Descartes 0.08 115.63
EVL 0.0000362 4403 GTEx DepMap Descartes 0.77 359.24
RBMS3 0.0000362 4404 GTEx DepMap Descartes 3.21 712.38
ACVR1B 0.0000299 4537 GTEx DepMap Descartes 0.15 63.69
EML4 0.0000298 4540 GTEx DepMap Descartes 0.66 215.38


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.59e-70
Mean rank of genes in gene set: 3256.34
Median rank of genes in gene set: 1288
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL1A1 0.0310094 1 GTEx DepMap Descartes 12.50 4506.94
COL3A1 0.0253399 2 GTEx DepMap Descartes 9.04 3626.58
SPARC 0.0157295 7 GTEx DepMap Descartes 4.67 2862.77
POSTN 0.0154492 8 GTEx DepMap Descartes 2.22 1299.99
FN1 0.0152264 9 GTEx DepMap Descartes 6.08 1259.02
COL6A3 0.0108987 12 GTEx DepMap Descartes 1.58 306.95
COL5A2 0.0101766 13 GTEx DepMap Descartes 2.70 846.73
COL5A1 0.0100927 14 GTEx DepMap Descartes 1.25 320.84
COL6A2 0.0097484 15 GTEx DepMap Descartes 2.18 1226.54
FBN1 0.0092829 17 GTEx DepMap Descartes 1.49 251.75
BGN 0.0090765 18 GTEx DepMap Descartes 1.24 1260.80
COL12A1 0.0088718 19 GTEx DepMap Descartes 1.27 243.95
AEBP1 0.0085236 20 GTEx DepMap Descartes 2.82 1557.76
FSTL1 0.0082068 21 GTEx DepMap Descartes 1.18 455.96
CCDC80 0.0063788 23 GTEx DepMap Descartes 0.59 96.66
TIMP1 0.0060792 26 GTEx DepMap Descartes 3.41 5827.85
TNC 0.0059465 27 GTEx DepMap Descartes 0.86 207.24
PRRX1 0.0058900 28 GTEx DepMap Descartes 0.69 406.64
MGP 0.0058735 29 GTEx DepMap Descartes 1.57 1945.74
COL6A1 0.0054267 30 GTEx DepMap Descartes 1.31 656.95
CDH11 0.0049520 35 GTEx DepMap Descartes 1.02 311.34
BNC2 0.0047459 41 GTEx DepMap Descartes 1.31 215.02
COL11A1 0.0045260 45 GTEx DepMap Descartes 0.63 173.00
MMP2 0.0043308 48 GTEx DepMap Descartes 0.84 577.86
SEMA3C 0.0040507 52 GTEx DepMap Descartes 0.75 287.18
GSN 0.0039489 54 GTEx DepMap Descartes 0.62 179.81
IGFBP5 0.0038836 55 GTEx DepMap Descartes 0.44 133.96
MRC2 0.0038419 58 GTEx DepMap Descartes 0.69 296.35
CILP 0.0037851 59 GTEx DepMap Descartes 0.11 48.51
CYBRD1 0.0035942 65 GTEx DepMap Descartes 0.20 107.07


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.32e-01
Mean rank of genes in gene set: 7173.89
Median rank of genes in gene set: 7653
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ERN1 0.0008739 397 GTEx DepMap Descartes 0.10 27.52
SH3PXD2B 0.0008085 444 GTEx DepMap Descartes 0.35 92.08
APOC1 0.0004133 960 GTEx DepMap Descartes 0.21 679.93
PAPSS2 0.0002140 1892 GTEx DepMap Descartes 0.08 38.84
INHA 0.0001538 2478 GTEx DepMap Descartes 0.03 23.41
POR 0.0001270 2808 GTEx DepMap Descartes 0.08 55.61
FDX1 0.0001130 2981 GTEx DepMap Descartes 0.05 28.01
FDXR 0.0000937 3292 GTEx DepMap Descartes 0.04 21.09
CYB5B 0.0000728 3677 GTEx DepMap Descartes 0.15 52.81
TM7SF2 0.0000313 4508 GTEx DepMap Descartes 0.05 21.64
FDPS 0.0000220 4746 GTEx DepMap Descartes 0.30 256.92
DHCR24 0.0000199 4811 GTEx DepMap Descartes 0.09 38.27
SH3BP5 0.0000057 5192 GTEx DepMap Descartes 0.07 26.64
STAR -0.0000178 5865 GTEx DepMap Descartes 0.00 0.00
DHCR7 -0.0000261 6110 GTEx DepMap Descartes 0.02 16.12
GRAMD1B -0.0000305 6248 GTEx DepMap Descartes 0.05 11.69
NPC1 -0.0000649 7367 GTEx DepMap Descartes 0.15 58.07
SCAP -0.0000725 7609 GTEx DepMap Descartes 0.16 55.13
BAIAP2L1 -0.0000753 7697 GTEx DepMap Descartes 0.05 15.73
FREM2 -0.0000978 8405 GTEx DepMap Descartes 0.00 0.00
SCARB1 -0.0001088 8731 GTEx DepMap Descartes 0.13 56.82
IGF1R -0.0001206 9054 GTEx DepMap Descartes 0.70 94.10
FRMD5 -0.0001288 9271 GTEx DepMap Descartes 0.36 106.82
SLC16A9 -0.0001329 9377 GTEx DepMap Descartes 0.03 22.19
PEG3 -0.0001632 10089 GTEx DepMap Descartes 0.06 NA
SGCZ -0.0001656 10123 GTEx DepMap Descartes 0.08 25.70
CLU -0.0001690 10197 GTEx DepMap Descartes 0.73 327.35
DNER -0.0001954 10695 GTEx DepMap Descartes 0.07 41.48
HMGCS1 -0.0002076 10895 GTEx DepMap Descartes 0.04 11.74
MSMO1 -0.0002249 11154 GTEx DepMap Descartes 0.02 2.09


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11066.41
Median rank of genes in gene set: 11995
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FAT3 0.0001965 2031 GTEx DepMap Descartes 0.10 10.37
GAL -0.0000310 6263 GTEx DepMap Descartes 0.30 871.51
SLC44A5 -0.0000574 7097 GTEx DepMap Descartes 0.07 30.23
MAB21L1 -0.0000584 7140 GTEx DepMap Descartes 0.06 47.36
RBFOX1 -0.0001049 8602 GTEx DepMap Descartes 1.32 336.35
PLXNA4 -0.0001115 8797 GTEx DepMap Descartes 0.08 6.82
PTCHD1 -0.0001156 8902 GTEx DepMap Descartes 0.06 6.87
NTRK1 -0.0001197 9033 GTEx DepMap Descartes 0.09 60.07
HS3ST5 -0.0001243 9138 GTEx DepMap Descartes 0.24 75.60
EYA4 -0.0002117 10960 GTEx DepMap Descartes 0.30 61.97
ANKFN1 -0.0002421 11353 GTEx DepMap Descartes 0.11 20.12
EYA1 -0.0002548 11495 GTEx DepMap Descartes 0.38 116.35
TMEFF2 -0.0002562 11502 GTEx DepMap Descartes 0.02 11.70
REEP1 -0.0002569 11507 GTEx DepMap Descartes 0.07 24.99
SYNPO2 -0.0002776 11685 GTEx DepMap Descartes 0.38 38.35
RGMB -0.0002799 11706 GTEx DepMap Descartes 0.09 36.28
MAB21L2 -0.0002827 11727 GTEx DepMap Descartes 0.02 4.09
RPH3A -0.0003089 11906 GTEx DepMap Descartes 0.04 10.31
EPHA6 -0.0003165 11935 GTEx DepMap Descartes 0.12 37.10
CNTFR -0.0003267 11989 GTEx DepMap Descartes 0.02 17.97
SLC6A2 -0.0003278 11995 GTEx DepMap Descartes 0.06 20.90
CNKSR2 -0.0003380 12039 GTEx DepMap Descartes 0.24 43.81
TUBB2A -0.0003391 12046 GTEx DepMap Descartes 0.14 164.36
KCNB2 -0.0003648 12137 GTEx DepMap Descartes 0.37 130.74
GAP43 -0.0003850 12201 GTEx DepMap Descartes 0.21 156.49
BASP1 -0.0003878 12206 GTEx DepMap Descartes 0.31 326.89
MARCH11 -0.0003977 12235 GTEx DepMap Descartes 0.26 NA
TMEM132C -0.0004308 12308 GTEx DepMap Descartes 0.45 110.75
ISL1 -0.0004431 12326 GTEx DepMap Descartes 0.25 174.80
ALK -0.0004524 12342 GTEx DepMap Descartes 1.13 245.44


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 7698
Median rank of genes in gene set: 8943.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CDH13 0.0007126 514 GTEx DepMap Descartes 0.31 43.25
NPR1 0.0003301 1223 GTEx DepMap Descartes 0.03 5.30
IRX3 0.0002389 1707 GTEx DepMap Descartes 0.02 14.29
BTNL9 0.0001912 2072 GTEx DepMap Descartes 0.02 1.69
CDH5 0.0001279 2796 GTEx DepMap Descartes 0.02 2.55
MMRN2 0.0001009 3166 GTEx DepMap Descartes 0.02 5.59
MYRIP 0.0000970 3232 GTEx DepMap Descartes 0.11 53.50
PLVAP 0.0000780 3559 GTEx DepMap Descartes 0.11 39.93
SHE 0.0000740 3645 GTEx DepMap Descartes 0.04 8.93
CYP26B1 0.0000532 4032 GTEx DepMap Descartes 0.02 10.70
TIE1 0.0000125 5022 GTEx DepMap Descartes 0.05 14.14
RASIP1 -0.0000051 5480 GTEx DepMap Descartes 0.04 17.27
NOTCH4 -0.0000093 5602 GTEx DepMap Descartes 0.05 12.70
ESM1 -0.0000102 5626 GTEx DepMap Descartes 0.02 3.90
HYAL2 -0.0000128 5708 GTEx DepMap Descartes 0.04 11.85
GALNT15 -0.0000250 6076 GTEx DepMap Descartes 0.02 NA
TEK -0.0000583 7134 GTEx DepMap Descartes 0.02 1.51
KANK3 -0.0000662 7407 GTEx DepMap Descartes 0.01 4.84
F8 -0.0001086 8723 GTEx DepMap Descartes 0.01 0.26
CEACAM1 -0.0001251 9164 GTEx DepMap Descartes 0.03 16.64
SLCO2A1 -0.0001340 9406 GTEx DepMap Descartes 0.04 14.91
PODXL -0.0001400 9563 GTEx DepMap Descartes 0.09 19.70
RAMP2 -0.0001509 9804 GTEx DepMap Descartes 0.05 50.84
CLDN5 -0.0001537 9865 GTEx DepMap Descartes 0.08 23.47
EHD3 -0.0001816 10440 GTEx DepMap Descartes 0.01 2.28
CALCRL -0.0001830 10462 GTEx DepMap Descartes 0.18 38.30
ARHGAP29 -0.0002035 10823 GTEx DepMap Descartes 0.19 25.83
SHANK3 -0.0002066 10878 GTEx DepMap Descartes 0.02 6.44
CRHBP -0.0002333 11259 GTEx DepMap Descartes 0.00 0.00
ROBO4 -0.0002708 11640 GTEx DepMap Descartes 0.06 8.18


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.06e-18
Mean rank of genes in gene set: 1545.3
Median rank of genes in gene set: 143.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL1A1 0.0310094 1 GTEx DepMap Descartes 12.50 4506.94
COL3A1 0.0253399 2 GTEx DepMap Descartes 9.04 3626.58
COL1A2 0.0241917 3 GTEx DepMap Descartes 15.10 6019.95
LUM 0.0169930 4 GTEx DepMap Descartes 1.45 1247.53
POSTN 0.0154492 8 GTEx DepMap Descartes 2.22 1299.99
DCN 0.0121242 11 GTEx DepMap Descartes 1.03 340.72
COL6A3 0.0108987 12 GTEx DepMap Descartes 1.58 306.95
COL12A1 0.0088718 19 GTEx DepMap Descartes 1.27 243.95
CCDC80 0.0063788 23 GTEx DepMap Descartes 0.59 96.66
PRRX1 0.0058900 28 GTEx DepMap Descartes 0.69 406.64
MGP 0.0058735 29 GTEx DepMap Descartes 1.57 1945.74
CDH11 0.0049520 35 GTEx DepMap Descartes 1.02 311.34
SFRP2 0.0048395 38 GTEx DepMap Descartes 0.61 677.97
ISLR 0.0046990 42 GTEx DepMap Descartes 0.47 455.58
LOX 0.0046669 43 GTEx DepMap Descartes 0.22 114.45
EDNRA 0.0034323 72 GTEx DepMap Descartes 0.16 81.45
ELN 0.0031610 78 GTEx DepMap Descartes 0.76 457.32
ITGA11 0.0030784 82 GTEx DepMap Descartes 0.34 65.69
ADAMTS2 0.0030688 84 GTEx DepMap Descartes 0.52 155.74
PRICKLE1 0.0029750 91 GTEx DepMap Descartes 1.10 397.94
IGFBP3 0.0024808 111 GTEx DepMap Descartes 0.28 141.65
ACTA2 0.0024096 121 GTEx DepMap Descartes 0.43 520.18
PDGFRA 0.0018956 166 GTEx DepMap Descartes 0.21 107.46
ABCA6 0.0016950 190 GTEx DepMap Descartes 0.16 38.33
ABCC9 0.0015157 209 GTEx DepMap Descartes 0.16 42.80
PCOLCE 0.0012360 270 GTEx DepMap Descartes 0.56 741.92
CD248 0.0011429 293 GTEx DepMap Descartes 0.18 132.77
BICC1 0.0011041 311 GTEx DepMap Descartes 1.26 555.62
PCDH18 0.0009593 355 GTEx DepMap Descartes 0.02 3.14
OGN 0.0009012 378 GTEx DepMap Descartes 0.06 36.70


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8958.74
Median rank of genes in gene set: 10404
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PENK 0.0005789 649 GTEx DepMap Descartes 0.02 53.67
TENM1 0.0004195 943 GTEx DepMap Descartes 0.35 NA
AGBL4 0.0003844 1037 GTEx DepMap Descartes 0.89 251.11
SORCS3 0.0001228 2858 GTEx DepMap Descartes 0.03 11.38
DGKK 0.0001086 3055 GTEx DepMap Descartes 0.02 2.73
SLC24A2 0.0000768 3595 GTEx DepMap Descartes 0.03 4.95
LAMA3 0.0000739 3647 GTEx DepMap Descartes 0.08 7.86
TBX20 0.0000696 3729 GTEx DepMap Descartes 0.08 93.06
SLC35F3 -0.0000014 5379 GTEx DepMap Descartes 0.29 140.05
CNTN3 -0.0000604 7201 GTEx DepMap Descartes 0.02 12.88
CHGA -0.0000629 7287 GTEx DepMap Descartes 1.95 1803.30
UNC80 -0.0000859 8052 GTEx DepMap Descartes 0.25 26.60
SLC18A1 -0.0001440 9638 GTEx DepMap Descartes 0.14 84.36
PACRG -0.0001448 9653 GTEx DepMap Descartes 0.15 105.24
GRID2 -0.0001659 10132 GTEx DepMap Descartes 0.03 6.62
KCTD16 -0.0001712 10259 GTEx DepMap Descartes 0.25 31.88
C1QL1 -0.0001732 10285 GTEx DepMap Descartes 0.08 105.75
CDH12 -0.0001764 10352 GTEx DepMap Descartes 0.03 5.44
TIAM1 -0.0001790 10401 GTEx DepMap Descartes 0.28 58.53
ARC -0.0001796 10407 GTEx DepMap Descartes 0.04 33.39
GCH1 -0.0001912 10616 GTEx DepMap Descartes 0.18 109.85
ROBO1 -0.0001949 10686 GTEx DepMap Descartes 0.73 138.97
ST18 -0.0001996 10765 GTEx DepMap Descartes 0.18 69.86
HTATSF1 -0.0002556 11498 GTEx DepMap Descartes 0.06 25.67
SPOCK3 -0.0002666 11596 GTEx DepMap Descartes 0.04 22.41
EML6 -0.0002717 11650 GTEx DepMap Descartes 0.37 64.70
CHGB -0.0002730 11660 GTEx DepMap Descartes 0.69 601.64
KSR2 -0.0002732 11663 GTEx DepMap Descartes 0.09 7.34
PCSK2 -0.0002995 11851 GTEx DepMap Descartes 0.24 99.98
MGAT4C -0.0003154 11929 GTEx DepMap Descartes 0.27 19.89


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.19e-01
Mean rank of genes in gene set: 6886.83
Median rank of genes in gene set: 8193
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MICAL2 0.0018006 173 GTEx DepMap Descartes 0.36 100.12
GYPC 0.0004138 958 GTEx DepMap Descartes 0.05 35.10
SELENBP1 0.0003007 1344 GTEx DepMap Descartes 0.03 35.61
BLVRB 0.0002000 1996 GTEx DepMap Descartes 0.02 24.85
SOX6 0.0001808 2162 GTEx DepMap Descartes 0.24 38.45
CAT 0.0001092 3049 GTEx DepMap Descartes 0.08 59.81
CPOX 0.0000590 3926 GTEx DepMap Descartes 0.02 14.51
ALAS2 -0.0000042 5458 GTEx DepMap Descartes 0.00 0.00
DENND4A -0.0000111 5660 GTEx DepMap Descartes 0.47 100.11
SPTB -0.0000120 5685 GTEx DepMap Descartes 0.05 7.31
TMCC2 -0.0000175 5862 GTEx DepMap Descartes 0.01 0.59
SLC4A1 -0.0000262 6118 GTEx DepMap Descartes 0.00 0.00
SLC25A21 -0.0000278 6158 GTEx DepMap Descartes 0.01 2.83
XPO7 -0.0000339 6356 GTEx DepMap Descartes 0.12 55.71
TSPAN5 -0.0000908 8193 GTEx DepMap Descartes 0.34 93.38
GCLC -0.0000956 8334 GTEx DepMap Descartes 0.09 47.87
TRAK2 -0.0001058 8628 GTEx DepMap Descartes 0.08 27.42
ABCB10 -0.0001060 8638 GTEx DepMap Descartes 0.05 26.58
FECH -0.0001091 8739 GTEx DepMap Descartes 0.02 2.16
SLC25A37 -0.0001099 8762 GTEx DepMap Descartes 0.17 60.92
ANK1 -0.0001174 8953 GTEx DepMap Descartes 0.10 13.35
RGS6 -0.0001338 9400 GTEx DepMap Descartes 0.00 0.00
SPECC1 -0.0001401 9567 GTEx DepMap Descartes 0.02 1.41
TFR2 -0.0001510 9811 GTEx DepMap Descartes 0.08 24.94
RHD -0.0001695 10212 GTEx DepMap Descartes 0.02 6.67
EPB41 -0.0002011 10785 GTEx DepMap Descartes 0.17 40.51
SNCA -0.0002443 11381 GTEx DepMap Descartes 0.02 4.94
RAPGEF2 -0.0002456 11407 GTEx DepMap Descartes 0.22 63.36
MARCH3 -0.0003291 12003 GTEx DepMap Descartes 0.20 NA
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 7582.76
Median rank of genes in gene set: 9703.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CST3 0.0021190 147 GTEx DepMap Descartes 0.50 306.50
AXL 0.0014796 219 GTEx DepMap Descartes 0.24 121.19
CTSD 0.0008812 390 GTEx DepMap Descartes 0.79 790.13
PTPRE 0.0008232 432 GTEx DepMap Descartes 0.45 121.02
SPP1 0.0007982 451 GTEx DepMap Descartes 0.56 747.93
SLC1A3 0.0007457 488 GTEx DepMap Descartes 0.07 38.55
CTSB 0.0006531 581 GTEx DepMap Descartes 0.35 193.93
TGFBI 0.0004323 913 GTEx DepMap Descartes 0.18 64.80
LGMN 0.0003053 1327 GTEx DepMap Descartes 0.20 130.88
FGL2 0.0001655 2315 GTEx DepMap Descartes 0.02 4.84
ITPR2 0.0001343 2708 GTEx DepMap Descartes 0.45 70.54
CTSS 0.0001153 2947 GTEx DepMap Descartes 0.13 65.84
CD163 0.0001014 3158 GTEx DepMap Descartes 0.03 12.71
CD74 0.0000078 5131 GTEx DepMap Descartes 0.33 129.88
CYBB -0.0000219 5985 GTEx DepMap Descartes 0.02 2.20
WWP1 -0.0000903 8183 GTEx DepMap Descartes 0.17 67.94
HRH1 -0.0000926 8251 GTEx DepMap Descartes 0.14 57.95
CTSC -0.0001157 8904 GTEx DepMap Descartes 0.11 32.23
MS4A4A -0.0001255 9176 GTEx DepMap Descartes 0.00 0.00
FGD2 -0.0001703 10231 GTEx DepMap Descartes 0.03 5.71
CPVL -0.0001813 10435 GTEx DepMap Descartes 0.03 28.66
CD14 -0.0002339 11266 GTEx DepMap Descartes 0.06 74.08
IFNGR1 -0.0002681 11618 GTEx DepMap Descartes 0.11 79.95
SFMBT2 -0.0002712 11645 GTEx DepMap Descartes 0.26 56.00
CSF1R -0.0002778 11689 GTEx DepMap Descartes 0.04 9.66
MARCH1 -0.0002843 11741 GTEx DepMap Descartes 0.05 NA
HCK -0.0003175 11940 GTEx DepMap Descartes 0.02 7.41
ABCA1 -0.0003319 12012 GTEx DepMap Descartes 0.17 38.52
RGL1 -0.0003441 12069 GTEx DepMap Descartes 0.10 28.77
CD163L1 -0.0004072 12257 GTEx DepMap Descartes 0.02 5.43


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.67e-02
Mean rank of genes in gene set: 5221.82
Median rank of genes in gene set: 4248
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL5A2 0.0101766 13 GTEx DepMap Descartes 2.70 846.73
VCAN 0.0063658 24 GTEx DepMap Descartes 2.01 319.34
COL18A1 0.0017038 186 GTEx DepMap Descartes 0.88 272.83
NRXN3 0.0011416 294 GTEx DepMap Descartes 0.46 77.01
PMP22 0.0011147 307 GTEx DepMap Descartes 0.41 484.99
LAMA4 0.0010973 315 GTEx DepMap Descartes 0.22 58.06
STARD13 0.0008573 404 GTEx DepMap Descartes 0.32 111.08
LAMC1 0.0006832 544 GTEx DepMap Descartes 0.61 128.62
MPZ 0.0005614 674 GTEx DepMap Descartes 0.01 5.06
OLFML2A 0.0005537 688 GTEx DepMap Descartes 0.02 7.24
GAS7 0.0005480 701 GTEx DepMap Descartes 0.49 119.65
LAMB1 0.0004727 825 GTEx DepMap Descartes 0.34 84.48
PTPRZ1 0.0003075 1315 GTEx DepMap Descartes 0.00 0.00
SFRP1 0.0002710 1489 GTEx DepMap Descartes 0.15 68.87
PLCE1 0.0002586 1566 GTEx DepMap Descartes 0.15 20.40
ERBB3 0.0002485 1633 GTEx DepMap Descartes 0.00 0.00
KCTD12 0.0002279 1793 GTEx DepMap Descartes 0.05 13.90
IL1RAPL2 0.0001916 2070 GTEx DepMap Descartes 0.03 37.29
HMGA2 0.0001802 2168 GTEx DepMap Descartes 0.01 2.54
ADAMTS5 0.0001383 2665 GTEx DepMap Descartes 0.04 2.55
PLP1 0.0000723 3686 GTEx DepMap Descartes 0.00 0.00
PTN 0.0000616 3877 GTEx DepMap Descartes 0.18 160.92
COL25A1 0.0000270 4619 GTEx DepMap Descartes 0.02 4.21
FIGN -0.0000159 5816 GTEx DepMap Descartes 0.15 27.54
EDNRB -0.0000194 5907 GTEx DepMap Descartes 0.03 5.89
GFRA3 -0.0000308 6258 GTEx DepMap Descartes 0.08 57.08
SLC35F1 -0.0000337 6351 GTEx DepMap Descartes 0.02 2.46
SOX5 -0.0000510 6907 GTEx DepMap Descartes 0.19 60.00
MDGA2 -0.0000653 7381 GTEx DepMap Descartes 0.00 0.00
GRIK3 -0.0000769 7754 GTEx DepMap Descartes 0.02 4.05


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.54e-03
Mean rank of genes in gene set: 4964.69
Median rank of genes in gene set: 3120
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GSN 0.0039489 54 GTEx DepMap Descartes 0.62 179.81
MYH9 0.0018789 168 GTEx DepMap Descartes 0.60 143.21
ACTB 0.0010979 314 GTEx DepMap Descartes 3.53 3124.94
THBS1 0.0010776 321 GTEx DepMap Descartes 2.26 608.54
SLC2A3 0.0007529 485 GTEx DepMap Descartes 0.50 229.02
STOM 0.0007087 516 GTEx DepMap Descartes 0.18 99.90
CD9 0.0005531 689 GTEx DepMap Descartes 0.16 194.64
ACTN1 0.0005122 759 GTEx DepMap Descartes 0.56 237.46
VCL 0.0005072 763 GTEx DepMap Descartes 0.40 93.22
MYLK 0.0004794 811 GTEx DepMap Descartes 0.21 46.48
LTBP1 0.0004517 866 GTEx DepMap Descartes 0.34 94.65
TMSB4X 0.0003870 1033 GTEx DepMap Descartes 2.02 1727.58
TGFB1 0.0003713 1080 GTEx DepMap Descartes 0.17 118.44
SLC24A3 0.0003629 1103 GTEx DepMap Descartes 0.19 76.50
TPM4 0.0003603 1107 GTEx DepMap Descartes 0.40 143.98
SPN 0.0002373 1717 GTEx DepMap Descartes 0.00 0.00
FLNA 0.0002247 1818 GTEx DepMap Descartes 0.85 159.98
RAP1B 0.0001401 2646 GTEx DepMap Descartes 0.34 49.89
ANGPT1 0.0001354 2694 GTEx DepMap Descartes 0.03 7.00
ARHGAP6 0.0001251 2835 GTEx DepMap Descartes 0.08 27.50
ZYX 0.0001126 2991 GTEx DepMap Descartes 0.15 108.02
PDE3A 0.0001109 3022 GTEx DepMap Descartes 0.59 168.60
TLN1 0.0001038 3120 GTEx DepMap Descartes 0.09 14.19
FLI1 0.0000729 3674 GTEx DepMap Descartes 0.22 52.26
PSTPIP2 0.0000463 4204 GTEx DepMap Descartes 0.01 2.21
LIMS1 -0.0000093 5600 GTEx DepMap Descartes 0.35 135.82
FERMT3 -0.0000171 5849 GTEx DepMap Descartes 0.02 21.06
ITGB3 -0.0000213 5964 GTEx DepMap Descartes 0.00 0.00
UBASH3B -0.0000327 6319 GTEx DepMap Descartes 0.16 47.30
TRPC6 -0.0000412 6581 GTEx DepMap Descartes 0.05 16.20


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.07e-01
Mean rank of genes in gene set: 5993.48
Median rank of genes in gene set: 4761
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0025662 107 GTEx DepMap Descartes 2.24 1398.18
FOXP1 0.0012270 274 GTEx DepMap Descartes 2.37 509.28
ARID5B 0.0012108 276 GTEx DepMap Descartes 0.63 165.13
MBNL1 0.0007758 473 GTEx DepMap Descartes 1.08 306.70
CELF2 0.0005762 654 GTEx DepMap Descartes 0.61 146.78
MSN 0.0005755 656 GTEx DepMap Descartes 0.20 74.65
SP100 0.0005639 672 GTEx DepMap Descartes 0.25 66.04
LEF1 0.0005198 748 GTEx DepMap Descartes 0.08 29.27
NCALD 0.0005069 764 GTEx DepMap Descartes 0.29 113.36
ETS1 0.0003800 1050 GTEx DepMap Descartes 0.20 49.93
PLEKHA2 0.0003747 1069 GTEx DepMap Descartes 0.13 38.47
ARHGDIB 0.0003602 1108 GTEx DepMap Descartes 0.07 51.68
WIPF1 0.0003109 1305 GTEx DepMap Descartes 0.25 93.43
CCL5 0.0002899 1405 GTEx DepMap Descartes 0.02 24.14
CCND3 0.0002390 1706 GTEx DepMap Descartes 0.17 132.06
ANKRD44 0.0001119 2997 GTEx DepMap Descartes 0.37 85.59
ABLIM1 0.0001118 3002 GTEx DepMap Descartes 0.17 30.97
BACH2 0.0001069 3077 GTEx DepMap Descartes 0.50 102.30
PTPRC 0.0001060 3090 GTEx DepMap Descartes 0.04 8.49
EVL 0.0000362 4403 GTEx DepMap Descartes 0.77 359.24
LCP1 0.0000271 4618 GTEx DepMap Descartes 0.02 10.84
PRKCH 0.0000170 4904 GTEx DepMap Descartes 0.15 54.58
SAMD3 -0.0000210 5954 GTEx DepMap Descartes 0.06 35.32
DOCK10 -0.0000503 6878 GTEx DepMap Descartes 0.34 69.17
SKAP1 -0.0000654 7384 GTEx DepMap Descartes 0.05 30.44
STK39 -0.0000828 7962 GTEx DepMap Descartes 0.26 139.90
RCSD1 -0.0001630 10080 GTEx DepMap Descartes 0.06 17.98
SCML4 -0.0001787 10398 GTEx DepMap Descartes 0.11 30.04
FYN -0.0001857 10519 GTEx DepMap Descartes 0.47 209.23
TOX -0.0002115 10956 GTEx DepMap Descartes 0.66 290.29


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.48e-04
Mean rank of genes in gene set: 1906.44
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PRRX1 0.0058900 28 GTEx DepMap Descartes 0.69 406.64
SMOC2 0.0036357 63 GTEx DepMap Descartes 0.44 282.35
PDGFRA 0.0018956 166 GTEx DepMap Descartes 0.21 107.46
EBF2 0.0014948 212 GTEx DepMap Descartes 0.08 28.61
OLFML1 0.0005563 684 GTEx DepMap Descartes 0.02 6.91
NTRK2 0.0004722 827 GTEx DepMap Descartes 0.11 24.27
SFRP1 0.0002710 1489 GTEx DepMap Descartes 0.15 68.87
F10 0.0000265 4639 GTEx DepMap Descartes 0.02 44.60
ANGPTL1 -0.0001204 9050 GTEx DepMap Descartes 0.09 34.93


Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.36e-03
Mean rank of genes in gene set: 5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A1 0.0310094 1 GTEx DepMap Descartes 12.50 4506.94
COL1A2 0.0241917 3 GTEx DepMap Descartes 15.10 6019.95
DCN 0.0121242 11 GTEx DepMap Descartes 1.03 340.72


T cells: Trm cytotoxic T cells (curated markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.91e-02
Mean rank of genes in gene set: 1422.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ITGA1 0.0011176 306 GTEx DepMap Descartes 0.60 108.73
ITGAE 0.0001490 2539 GTEx DepMap Descartes 0.15 59.28