Program: 1. Neuroblastoma #1.

Program: 1. Neuroblastoma #1.

Program description and justification of annotation: 1.
Submit a comment on this gene expression program’s interpretation: CLICK

QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 LPIN1 0.0268371 lipin 1 GTEx DepMap Descartes 29.53 11307.80
2 TRIB2 0.0165954 tribbles pseudokinase 2 GTEx DepMap Descartes 11.54 5645.14
3 HPCAL1 0.0154276 hippocalcin like 1 GTEx DepMap Descartes 5.64 2506.33
4 CUX2 0.0114487 cut like homeobox 2 GTEx DepMap Descartes 5.02 1780.14
5 MSR1 0.0110912 macrophage scavenger receptor 1 GTEx DepMap Descartes 1.53 975.19
6 POU3F3 0.0106112 POU class 3 homeobox 3 GTEx DepMap Descartes 0.02 2.82
7 TENM2 0.0102060 teneurin transmembrane protein 2 GTEx DepMap Descartes 5.04 NA
8 IL1RAPL1 0.0094500 interleukin 1 receptor accessory protein like 1 GTEx DepMap Descartes 2.21 1098.85
9 CHRM3 0.0077571 cholinergic receptor muscarinic 3 GTEx DepMap Descartes 4.87 1033.01
10 NLGN1 0.0074634 neuroligin 1 GTEx DepMap Descartes 2.14 500.55
11 GREB1 0.0072447 growth regulating estrogen receptor binding 1 GTEx DepMap Descartes 2.07 469.02
12 ADAMTS16 0.0071073 ADAM metallopeptidase with thrombospondin type 1 motif 16 GTEx DepMap Descartes 0.53 213.92
13 SLIT3 0.0066896 slit guidance ligand 3 GTEx DepMap Descartes 5.47 1218.03
14 PCDH11X 0.0065039 protocadherin 11 X-linked GTEx DepMap Descartes 1.45 272.57
15 CTNNA2 0.0063079 catenin alpha 2 GTEx DepMap Descartes 10.39 4397.02
16 NRXN1 0.0061656 neurexin 1 GTEx DepMap Descartes 5.11 966.36
17 DLGAP1 0.0061592 DLG associated protein 1 GTEx DepMap Descartes 3.99 1287.34
18 ROCK2 0.0061182 Rho associated coiled-coil containing protein kinase 2 GTEx DepMap Descartes 3.71 869.44
19 KIF26B 0.0059179 kinesin family member 26B GTEx DepMap Descartes 4.53 682.51
20 NOL10 0.0057797 nucleolar protein 10 GTEx DepMap Descartes 2.90 1641.80
21 NTRK2 0.0056847 neurotrophic receptor tyrosine kinase 2 GTEx DepMap Descartes 0.72 154.45
22 CSMD1 0.0053391 CUB and Sushi multiple domains 1 GTEx DepMap Descartes 1.12 184.60
23 ALK 0.0052722 ALK receptor tyrosine kinase GTEx DepMap Descartes 8.08 2734.65
24 GRM8 0.0052643 glutamate metabotropic receptor 8 GTEx DepMap Descartes 3.01 1575.28
25 PLCH1 0.0052431 phospholipase C eta 1 GTEx DepMap Descartes 0.39 105.31
26 CACNA1C 0.0048387 calcium voltage-gated channel subunit alpha1 C GTEx DepMap Descartes 2.66 424.36
27 HOXD10 0.0047070 homeobox D10 GTEx DepMap Descartes 0.49 524.90
28 FGF14 0.0046809 fibroblast growth factor 14 GTEx DepMap Descartes 8.44 1296.82
29 EPHA6 0.0046598 EPH receptor A6 GTEx DepMap Descartes 3.04 1286.23
30 SLC13A3 0.0044716 solute carrier family 13 member 3 GTEx DepMap Descartes 0.47 257.95
31 ODC1 0.0042756 ornithine decarboxylase 1 GTEx DepMap Descartes 2.18 1361.55
32 PRKCA 0.0041736 protein kinase C alpha GTEx DepMap Descartes 2.83 656.55
33 ATP6V1C2 0.0041437 ATPase H+ transporting V1 subunit C2 GTEx DepMap Descartes 0.60 455.60
34 LSAMP 0.0041373 limbic system associated membrane protein GTEx DepMap Descartes 4.54 860.18
35 FSTL4 0.0040458 follistatin like 4 GTEx DepMap Descartes 0.68 297.81
36 PTPRG 0.0039831 protein tyrosine phosphatase receptor type G GTEx DepMap Descartes 1.38 324.84
37 SORCS3 0.0039088 sortilin related VPS10 domain containing receptor 3 GTEx DepMap Descartes 0.26 88.06
38 CHSY3 0.0038687 chondroitin sulfate synthase 3 GTEx DepMap Descartes 0.81 373.53
39 KCNH1 0.0038611 potassium voltage-gated channel subfamily H member 1 GTEx DepMap Descartes 2.65 715.47
40 SULF2 0.0037960 sulfatase 2 GTEx DepMap Descartes 1.24 554.29
41 CSMD2 0.0037688 CUB and Sushi multiple domains 2 GTEx DepMap Descartes 1.02 175.20
42 VCAN 0.0036891 versican GTEx DepMap Descartes 0.70 108.69
43 PLD5 0.0036764 phospholipase D family member 5 GTEx DepMap Descartes 1.85 394.86
44 LDLRAD4 0.0036726 low density lipoprotein receptor class A domain containing 4 GTEx DepMap Descartes 1.96 NA
45 TLL2 0.0036648 tolloid like 2 GTEx DepMap Descartes 0.34 107.92
46 KCNAB1 0.0035449 potassium voltage-gated channel subfamily A regulatory beta subunit 1 GTEx DepMap Descartes 0.40 199.94
47 KALRN 0.0035078 kalirin RhoGEF kinase GTEx DepMap Descartes 2.03 385.03
48 NRG3 0.0034917 neuregulin 3 GTEx DepMap Descartes 2.66 1456.45
49 BNIPL 0.0033438 BCL2 interacting protein like GTEx DepMap Descartes 0.26 176.36
50 DNAH14 0.0031846 dynein axonemal heavy chain 14 GTEx DepMap Descartes 1.62 251.02


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UMAP plots showing activity of gene expression program identified in community:1. Neuroblastoma #1

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
LAKE_ADULT_KIDNEY_C1_EPITHELIAL_CELLS_UNASSIGNED 5.61e-06 41.71 10.17 6.27e-04 3.76e-03
4DLGAP1, SLC13A3, CSMD2, NRG3
 30
LAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES 9.96e-07 15.65 5.83 2.31e-04 6.68e-04
7CHRM3, CACNA1C, PRKCA, PTPRG, LDLRAD4, KALRN, NRG3
 137
DESCARTES_FETAL_LUNG_VISCERAL_NEURONS 1.13e-07 13.52 5.70 7.58e-05 7.58e-05
9CUX2, POU3F3, CTNNA2, DLGAP1, CSMD1, ALK, KCNH1, CSMD2, PLD5
 212
LAKE_ADULT_KIDNEY_C28_INTERSTITIUM 2.16e-05 17.14 5.17 2.07e-03 1.45e-02
5SLIT3, ROCK2, CACNA1C, PRKCA, KALRN
 86
LAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES 3.05e-05 11.43 3.92 2.56e-03 2.05e-02
6SLIT3, ROCK2, CACNA1C, PTPRG, KCNAB1, KALRN
 155
MENON_FETAL_KIDNEY_2_NEPHRON_PROGENITOR_CELLS 6.96e-04 19.44 3.72 3.33e-02 4.67e-01
3TRIB2, POU3F3, ODC1
 44
LAKE_ADULT_KIDNEY_C26_MESANGIAL_CELLS 6.36e-05 9.97 3.42 4.74e-03 4.27e-02
6IL1RAPL1, ROCK2, PRKCA, PTPRG, KALRN, NRG3
 177
LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM 3.45e-06 7.68 3.40 4.63e-04 2.31e-03
10TENM2, CHRM3, SLIT3, KIF26B, CSMD1, CACNA1C, SLC13A3, LSAMP, PTPRG, CSMD2
 417
MANNO_MIDBRAIN_NEUROTYPES_HDA1 1.37e-06 6.90 3.27 2.31e-04 9.23e-04
12LPIN1, CTNNA2, NRXN1, CSMD1, GRM8, CACNA1C, PRKCA, LSAMP, CHSY3, CSMD2, KCNAB1, KALRN
 584
MANNO_MIDBRAIN_NEUROTYPES_HGABA 1.07e-06 5.41 2.78 2.31e-04 7.18e-04
16LPIN1, MSR1, TENM2, NLGN1, PCDH11X, CTNNA2, NRXN1, CSMD1, CACNA1C, FGF14, PRKCA, LSAMP, SORCS3, CHSY3, CSMD2, VCAN
 1105
DESCARTES_FETAL_HEART_SATB2_LRRC7_POSITIVE_CELLS 1.11e-03 9.70 2.49 4.97e-02 7.46e-01
4POU3F3, PCDH11X, CSMD1, CSMD2
 116
LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2 6.12e-04 8.12 2.49 3.18e-02 4.11e-01
5NLGN1, DLGAP1, PTPRG, NRG3, DNAH14
 176
DESCARTES_MAIN_FETAL_MESANGIAL_CELLS 5.10e-03 20.80 2.32 1.49e-01 1.00e+00
2KIF26B, HOXD10
 27
DESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS 1.73e-03 8.56 2.20 6.67e-02 1.00e+00
4CHRM3, DLGAP1, KALRN, NRG3
 131
DESCARTES_FETAL_STOMACH_ENS_NEURONS 3.11e-03 11.23 2.19 1.04e-01 1.00e+00
3CUX2, CTNNA2, PLD5
 74
DESCARTES_FETAL_MUSCLE_SMOOTH_MUSCLE_CELLS 3.61e-03 10.64 2.07 1.10e-01 1.00e+00
3SLIT3, CACNA1C, KCNAB1
 78
MANNO_MIDBRAIN_NEUROTYPES_HNBGABA 2.46e-04 4.51 2.00 1.65e-02 1.65e-01
10LPIN1, NLGN1, NRXN1, CSMD1, GRM8, CACNA1C, FGF14, LSAMP, SORCS3, CSMD2
 703
ZHONG_PFC_C3_MICROGLIA 4.89e-04 4.96 2.00 2.98e-02 3.28e-01
8TENM2, PCDH11X, NRXN1, NTRK2, CSMD1, CACNA1C, LSAMP, CSMD2
 488
MANNO_MIDBRAIN_NEUROTYPES_HDA 6.16e-04 4.78 1.93 3.18e-02 4.13e-01
8CTNNA2, NRXN1, CSMD1, GRM8, PRKCA, LSAMP, FSTL4, KCNAB1
 506
DESCARTES_FETAL_INTESTINE_ENS_NEURONS 3.55e-03 6.97 1.80 1.10e-01 1.00e+00
4CUX2, CTNNA2, CSMD1, SORCS3
 160

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_SPERMATOGENESIS 9.90e-02 3.92 0.46 1.00e+00 1.00e+00
2LPIN1, GRM8
 135
HALLMARK_UV_RESPONSE_DN 1.10e-01 3.67 0.43 1.00e+00 1.00e+00
2PRKCA, KALRN
 144
HALLMARK_FATTY_ACID_METABOLISM 1.28e-01 3.34 0.39 1.00e+00 1.00e+00
2ODC1, PTPRG
 158
HALLMARK_MYOGENESIS 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2LPIN1, KCNH1
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 1.85e-01 2.63 0.31 1.00e+00 1.00e+00
2SLIT3, VCAN
 200
HALLMARK_NOTCH_SIGNALING 1.20e-01 8.23 0.20 1.00e+00 1.00e+00
1PRKCA
 32
HALLMARK_ANGIOGENESIS 1.34e-01 7.29 0.18 1.00e+00 1.00e+00
1VCAN
 36
HALLMARK_APICAL_SURFACE 1.61e-01 5.93 0.14 1.00e+00 1.00e+00
1SULF2
 44
HALLMARK_IL2_STAT5_SIGNALING 5.45e-01 1.29 0.03 1.00e+00 1.00e+00
1ODC1
 199
HALLMARK_HYPOXIA 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1PRKCA
 200
HALLMARK_G2M_CHECKPOINT 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ODC1
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1GREB1
 200
HALLMARK_APICAL_JUNCTION 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1VCAN
 200
HALLMARK_MYC_TARGETS_V1 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1ODC1
 200
HALLMARK_INFLAMMATORY_RESPONSE 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1MSR1
 200
HALLMARK_GLYCOLYSIS 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1VCAN
 200
HALLMARK_KRAS_SIGNALING_UP 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1TRIB2
 200
HALLMARK_KRAS_SIGNALING_DN 5.47e-01 1.28 0.03 1.00e+00 1.00e+00
1TENM2
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 1.05e-02 7.12 1.40 5.51e-01 1.00e+00
3ROCK2, CACNA1C, PRKCA
 115
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.07e-02 7.06 1.39 5.51e-01 1.00e+00
3CTNNA2, ROCK2, PRKCA
 116
KEGG_AXON_GUIDANCE 1.42e-02 6.33 1.24 5.51e-01 1.00e+00
3SLIT3, ROCK2, EPHA6
 129
KEGG_CELL_ADHESION_MOLECULES_CAMS 1.54e-02 6.14 1.21 5.51e-01 1.00e+00
3NLGN1, NRXN1, VCAN
 133
KEGG_VIBRIO_CHOLERAE_INFECTION 1.94e-02 10.01 1.15 5.51e-01 1.00e+00
2PRKCA, ATP6V1C2
 54
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 2.07e-02 9.64 1.11 5.51e-01 1.00e+00
2ROCK2, PRKCA
 56
KEGG_MAPK_SIGNALING_PATHWAY 2.00e-02 4.13 1.07 5.51e-01 1.00e+00
4NTRK2, CACNA1C, FGF14, PRKCA
 267
KEGG_CALCIUM_SIGNALING_PATHWAY 3.26e-02 4.56 0.90 6.45e-01 1.00e+00
3CHRM3, CACNA1C, PRKCA
 178
KEGG_LONG_TERM_POTENTIATION 3.13e-02 7.66 0.88 6.45e-01 1.00e+00
2CACNA1C, PRKCA
 70
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 3.47e-02 7.23 0.84 6.45e-01 1.00e+00
2CTNNA2, CACNA1C
 74
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 5.07e-02 3.80 0.75 7.85e-01 1.00e+00
3CHRM3, ROCK2, FGF14
 213
KEGG_ERBB_SIGNALING_PATHWAY 4.64e-02 6.13 0.71 7.84e-01 1.00e+00
2PRKCA, NRG3
 87
KEGG_GNRH_SIGNALING_PATHWAY 6.04e-02 5.26 0.61 8.64e-01 1.00e+00
2CACNA1C, PRKCA
 101
KEGG_PATHWAYS_IN_CANCER 1.32e-01 2.48 0.49 1.00e+00 1.00e+00
3CTNNA2, FGF14, PRKCA
 325
KEGG_TIGHT_JUNCTION 9.54e-02 4.01 0.47 1.00e+00 1.00e+00
2CTNNA2, PRKCA
 132
KEGG_WNT_SIGNALING_PATHWAY 1.19e-01 3.50 0.41 1.00e+00 1.00e+00
2ROCK2, PRKCA
 151
KEGG_FOCAL_ADHESION 1.83e-01 2.64 0.31 1.00e+00 1.00e+00
2ROCK2, PRKCA
 199
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE 8.40e-02 12.14 0.29 1.00e+00 1.00e+00
1CHSY3
 22
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.87e-01 1.93 0.23 1.00e+00 1.00e+00
2CHRM3, GRM8
 272
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 1.54e-01 6.22 0.15 1.00e+00 1.00e+00
1PRKCA
 42

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2p25 3.45e-07 18.49 6.86 9.58e-05 9.58e-05
7LPIN1, HPCAL1, GREB1, ROCK2, NOL10, ODC1, ATP6V1C2
 117
chr1q43 2.36e-02 8.98 1.03 1.00e+00 1.00e+00
2CHRM3, PLD5
 60
chr3q25 1.20e-01 3.47 0.41 1.00e+00 1.00e+00
2PLCH1, KCNAB1
 152
chr18p11 1.86e-01 2.62 0.31 1.00e+00 1.00e+00
2DLGAP1, LDLRAD4
 201
chr5q34 1.41e-01 6.89 0.17 1.00e+00 1.00e+00
1TENM2
 38
chr20q13 6.68e-01 1.31 0.15 1.00e+00 1.00e+00
2SLC13A3, SULF2
 400
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1MSR1
 45
chr3q11 1.81e-01 5.21 0.13 1.00e+00 1.00e+00
1EPHA6
 50
chr2p12 1.90e-01 4.91 0.12 1.00e+00 1.00e+00
1CTNNA2
 53
chr13q33 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1FGF14
 55
chr2p24 2.55e-01 3.49 0.09 1.00e+00 1.00e+00
1TRIB2
 74
chr2q12 2.70e-01 3.27 0.08 1.00e+00 1.00e+00
1POU3F3
 79
chrXp21 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1IL1RAPL1
 82
chr17q24 3.12e-01 2.74 0.07 1.00e+00 1.00e+00
1PRKCA
 94
chr5q23 3.57e-01 2.32 0.06 1.00e+00 1.00e+00
1CHSY3
 111
chr2p16 3.64e-01 2.26 0.06 1.00e+00 1.00e+00
1NRXN1
 114
chr3p14 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1PTPRG
 122
chr10q25 3.94e-01 2.04 0.05 1.00e+00 1.00e+00
1SORCS3
 126
chr7q31 4.01e-01 1.99 0.05 1.00e+00 1.00e+00
1GRM8
 129
chr1p35 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1CSMD2
 130

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
YNTTTNNNANGCARM_UNKNOWN 1.84e-04 15.97 4.06 1.64e-01 2.08e-01
4CACNA1C, FGF14, PLD5, TLL2
 72
TTGCWCAAY_CEBPB_02 1.97e-03 13.28 2.58 2.76e-01 1.00e+00
3SLIT3, FGF14, VCAN
 63
CDX2_Q5 5.27e-04 6.63 2.29 1.64e-01 5.97e-01
6POU3F3, IL1RAPL1, SLIT3, NRXN1, CACNA1C, LSAMP
 263
PAX4_01 5.80e-04 6.51 2.25 1.64e-01 6.58e-01
6POU3F3, IL1RAPL1, NRXN1, HOXD10, PTPRG, SORCS3
 268
TGATTTRY_GFI1_01 9.64e-04 5.88 2.03 2.19e-01 1.00e+00
6MSR1, CTNNA2, NRXN1, HOXD10, FGF14, LSAMP
 296
OCT1_B 3.84e-03 5.26 1.62 3.03e-01 1.00e+00
5NRXN1, ALK, CACNA1C, FGF14, TLL2
 269
AACTTT_UNKNOWN 5.19e-04 3.08 1.58 1.64e-01 5.88e-01
16HPCAL1, POU3F3, IL1RAPL1, NLGN1, GREB1, SLIT3, PCDH11X, NRXN1, ROCK2, ALK, HOXD10, FGF14, LSAMP, PTPRG, SORCS3, VCAN
 1928
OCT1_Q5_01 4.21e-03 5.14 1.58 3.03e-01 1.00e+00
5PCDH11X, NRXN1, ALK, FGF14, TLL2
 275
VDR_Q6 4.28e-03 5.13 1.58 3.03e-01 1.00e+00
5GREB1, ROCK2, NTRK2, FGF14, VCAN
 276
MYOGNF1_01 1.55e-02 11.31 1.29 4.77e-01 1.00e+00
2IL1RAPL1, ROCK2
 48
FOXF2_TARGET_GENES 1.98e-02 63.54 1.27 4.77e-01 1.00e+00
1HPCAL1
 5
CDPCR1_01 1.42e-02 6.33 1.24 4.77e-01 1.00e+00
3TRIB2, IL1RAPL1, HOXD10
 129
HNF6_Q6 1.40e-02 4.63 1.20 4.77e-01 1.00e+00
4IL1RAPL1, HOXD10, SULF2, KCNAB1
 239
BRN2_01 1.42e-02 4.61 1.19 4.77e-01 1.00e+00
4SLIT3, CACNA1C, FGF14, PTPRG
 240
PAX4_02 1.44e-02 4.59 1.19 4.77e-01 1.00e+00
4IL1RAPL1, HOXD10, PTPRG, KALRN
 241
ZF5_B 1.48e-02 4.55 1.18 4.77e-01 1.00e+00
4TRIB2, POU3F3, NRXN1, PTPRG
 243
CATRRAGC_UNKNOWN 1.73e-02 5.87 1.15 4.77e-01 1.00e+00
3NRXN1, HOXD10, FGF14
 139
WTTGKCTG_UNKNOWN 1.38e-02 3.32 1.15 4.77e-01 1.00e+00
6TRIB2, SLIT3, NRXN1, NTRK2, VCAN, TLL2
 519
AP3_Q6 1.64e-02 4.40 1.14 4.77e-01 1.00e+00
4MSR1, IL1RAPL1, NTRK2, HOXD10
 251
ICSBP_Q6 1.69e-02 4.37 1.13 4.77e-01 1.00e+00
4HPCAL1, IL1RAPL1, CACNA1C, PLD5
 253

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_BRAIN_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_SIGNALING_PATHWAY 2.31e-04 129.66 11.45 6.67e-02 1.00e+00
2NTRK2, FSTL4
 6
GOBP_POSTSYNAPTIC_DENSITY_PROTEIN_95_CLUSTERING 4.28e-04 86.37 8.33 9.71e-02 1.00e+00
2NLGN1, NRXN1
 8
GOBP_TRANS_SYNAPTIC_SIGNALING_BY_TRANS_SYNAPTIC_COMPLEX 4.28e-04 86.37 8.33 9.71e-02 1.00e+00
2IL1RAPL1, NLGN1
 8
GOBP_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY 3.13e-06 26.18 7.80 2.17e-02 2.34e-02
5CUX2, IL1RAPL1, NLGN1, NRXN1, NTRK2
 58
GOBP_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL 1.62e-04 33.18 6.19 5.50e-02 1.00e+00
3CUX2, NLGN1, NRXN1
 27
GOBP_PRESYNAPTIC_MEMBRANE_ORGANIZATION 8.35e-04 57.69 5.91 1.37e-01 1.00e+00
2IL1RAPL1, NLGN1
 11
GOBP_POSTSYNAPTIC_MEMBRANE_ASSEMBLY 8.35e-04 57.69 5.91 1.37e-01 1.00e+00
2NLGN1, NRXN1
 11
GOBP_MITOTIC_NUCLEAR_ENVELOPE_DISASSEMBLY 9.99e-04 51.89 5.39 1.44e-01 1.00e+00
2LPIN1, PRKCA
 12
GOBP_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION 9.99e-04 51.89 5.39 1.44e-01 1.00e+00
2NTRK2, HOXD10
 12
GOBP_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT 9.99e-04 51.89 5.39 1.44e-01 1.00e+00
2NLGN1, FSTL4
 12
GOBP_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT 9.06e-05 19.39 4.91 3.99e-02 6.78e-01
4CUX2, NLGN1, FSTL4, KALRN
 60
GOBP_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS 3.53e-04 24.91 4.72 9.44e-02 1.00e+00
3CUX2, IL1RAPL1, KALRN
 35
GOBP_REGULATION_OF_SYNAPSE_ASSEMBLY 3.49e-05 15.42 4.67 2.50e-02 2.61e-01
5CUX2, IL1RAPL1, NLGN1, NRXN1, NTRK2
 95
GOBP_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY 3.67e-05 15.25 4.62 2.50e-02 2.75e-01
5CUX2, IL1RAPL1, NLGN1, NRXN1, NTRK2
 96
GOBP_MEMBRANE_DISASSEMBLY 1.58e-03 39.95 4.27 2.03e-01 1.00e+00
2LPIN1, PRKCA
 15
GOBP_MEMBRANE_BIOGENESIS 5.65e-04 20.97 4.00 1.14e-01 1.00e+00
3IL1RAPL1, NLGN1, NRXN1
 41
GOBP_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT 6.07e-04 20.43 3.90 1.14e-01 1.00e+00
3CUX2, NLGN1, KALRN
 42
GOBP_NEURON_CELL_CELL_ADHESION 2.03e-03 34.68 3.75 2.41e-01 1.00e+00
2NLGN1, NRXN1
 17
GOBP_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL 6.96e-04 19.44 3.72 1.24e-01 1.00e+00
3CUX2, NLGN1, NRXN1
 44
GOBP_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY 1.83e-05 9.83 3.69 2.50e-02 1.37e-01
7CUX2, IL1RAPL1, NLGN1, CTNNA2, NRXN1, NTRK2, KALRN
 214

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE17721_PAM3CSK4_VS_CPG_6H_BMDC_DN 1.08e-03 7.12 2.18 1.00e+00 1.00e+00
5GRM8, ODC1, ATP6V1C2, VCAN, KALRN
 200
GSE43863_NAIVE_VS_TFH_CD4_EFF_TCELL_D6_LCMV_DN 6.70e-03 5.78 1.50 1.00e+00 1.00e+00
4MSR1, CHRM3, FGF14, PRKCA
 192
GSE21546_WT_VS_SAP1A_KO_DP_THYMOCYTES_DN 6.83e-03 5.75 1.49 1.00e+00 1.00e+00
4NTRK2, ODC1, PRKCA, FSTL4
 193
GSE22886_TH1_VS_TH2_48H_ACT_UP 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4IL1RAPL1, LSAMP, LDLRAD4, TLL2
 198
GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_DN 7.45e-03 5.60 1.45 1.00e+00 1.00e+00
4LPIN1, TRIB2, NRXN1, EPHA6
 198
GSE3982_EOSINOPHIL_VS_BCELL_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4CUX2, CHRM3, NRXN1, HOXD10
 199
GSE22527_ANTI_CD3_INVIVO_VS_UNTREATED_MOUSE_TREG_UP 7.58e-03 5.57 1.44 1.00e+00 1.00e+00
4CUX2, SLIT3, GRM8, CACNA1C
 199
GSE360_HIGH_VS_LOW_DOSE_B_MALAYI_DC_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4NTRK2, ALK, PLCH1, LSAMP
 200
GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_HET_TCONV_DN 7.71e-03 5.55 1.44 1.00e+00 1.00e+00
4PRKCA, ATP6V1C2, SULF2, LDLRAD4
 200
GSE10422_WT_VS_BAFF_TRANSGENIC_LN_BCELL_DN 1.42e-02 6.33 1.24 1.00e+00 1.00e+00
3HPCAL1, CTNNA2, NRXN1
 129
GSE38697_LIGHT_ZONE_VS_DARK_ZONE_BCELL_DN 1.45e-02 6.28 1.23 1.00e+00 1.00e+00
3TENM2, ALK, ATP6V1C2
 130
GSE40274_CTRL_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 2.34e-02 5.21 1.03 1.00e+00 1.00e+00
3HPCAL1, MSR1, SULF2
 156
GSE6674_UNSTIM_VS_PL2_3_STIM_BCELL_DN 3.04e-02 4.69 0.93 1.00e+00 1.00e+00
3ODC1, CHSY3, VCAN
 173
GSE21360_TERTIARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN 3.22e-02 4.59 0.90 1.00e+00 1.00e+00
3SLC13A3, ODC1, VCAN
 177
GSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_DN 3.74e-02 4.31 0.85 1.00e+00 1.00e+00
3TRIB2, LDLRAD4, KALRN
 188
GSE19198_1H_VS_6H_IL21_TREATED_TCELL_UP 3.74e-02 4.31 0.85 1.00e+00 1.00e+00
3PCDH11X, SULF2, NRG3
 188
GSE37416_CTRL_VS_0H_F_TULARENSIS_LVS_NEUTROPHIL_DN 3.79e-02 4.29 0.85 1.00e+00 1.00e+00
3CHRM3, DLGAP1, CSMD2
 189
GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_DN 3.84e-02 4.27 0.84 1.00e+00 1.00e+00
3NLGN1, SORCS3, PLD5
 190
GSE21670_IL6_VS_TGFB_AND_IL6_TREATED_CD4_TCELL_UP 3.99e-02 4.20 0.83 1.00e+00 1.00e+00
3TRIB2, MSR1, PRKCA
 193
GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_40H_TSST_ACT_UP 4.09e-02 4.16 0.82 1.00e+00 1.00e+00
3IL1RAPL1, CACNA1C, SLC13A3
 195

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
CUX2 4 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
POU3F3 6 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ALK 23 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates far upstream in the signaling cascade
HOXD10 27 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PBX3 51 Yes Known motif Monomer or homomultimer In vivo/Misc source None High sequence similarity to PBX1, PBX4, and drosophila exd, which have in vitro-derived motifs
HOXD3 52 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MYT1L 64 Yes Inferred motif Monomer or homomultimer High-throughput in vitro None None
BNC2 69 Yes Inferred motif Monomer or homomultimer In vivo/Misc source Has a putative AT-hook None
PRRX2 72 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FOXC1 73 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
DDR2 80 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
THRB 81 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PBX1 83 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FANCA 94 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Involved in DNA repair (PMID: 8896564)
BPTF 98 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook (PMID: 10575013) obtained a motif by SELEX and showed that mutating the sequence diminished binding in vitro. Unusual for a PHD/Ring finger, but its there in the literature.
POU6F2 107 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TOX 108 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Predicted to be a non- or low specificity TF (PMID: 12697058). However, there is a DAM-id based motif with SSSSGNNGCG-consensus (PMID: 25527292), but this does not look like HMG-site
TCF25 116 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Only evidence is based on (PMID:16574069), which claims that hnulp1 (TCF25) contains a possible bHLH domain and that it represses transcription in a Gal4-forced recruitment assay.
ZMAT4 118 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None Possible RBP.
DNMT3A 121 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None DNMT3A and DNMT3B are de novo methyltransferases that are activated by enzymatically inactive paralog DNMT3L. Besides the C-terminal catalytic core, the PWWP domain of 3A and 3B can also bind to DNA. Presumably there is no sequence specificity and instead the de novo methylation complexes are recruited by histone modifications on the N-terminal tail of H3. Reviewed in (PMID: 27826835).

QQ Plot showing correlations with other Gene Expression Programs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
NB11_GATCGCGAGCTGTTCA-1 Neurons:adrenal_medulla_cell_line 0.24 1274.34
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, iPS_cells:PDB_1lox-21Puro-20: 0.24, iPS_cells:PDB_1lox-21Puro-26: 0.24, iPS_cells:PDB_1lox-17Puro-10: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:PDB_1lox-17Puro-5: 0.24, iPS_cells:skin_fibroblast-derived: 0.23
NB11_GCACATAAGAGGTACC-1 Neurons:adrenal_medulla_cell_line 0.23 1203.71
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.31, Neuroepithelial_cell:ESC-derived: 0.26, Neurons:ES_cell-derived_neural_precursor: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.24, iPS_cells:PDB_1lox-21Puro-20: 0.23, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.22, iPS_cells:PDB_2lox-22: 0.21
NB11_CGTCCATTCGTAGATC-1 Neurons:adrenal_medulla_cell_line 0.22 961.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.27, Neurons:ES_cell-derived_neural_precursor: 0.27, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.25, Embryonic_stem_cells: 0.24, iPS_cells:PDB_2lox-22: 0.24
NB11_TTGTAGGCAGACAAGC-1 Neurons:adrenal_medulla_cell_line 0.23 926.02
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.33, Neuroepithelial_cell:ESC-derived: 0.29, Neurons:ES_cell-derived_neural_precursor: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, iPS_cells:PDB_1lox-21Puro-20: 0.25, iPS_cells:PDB_1lox-21Puro-26: 0.25, iPS_cells:PDB_1lox-17Puro-10: 0.25, iPS_cells:PDB_1lox-17Puro-5: 0.24, Embryonic_stem_cells: 0.24, iPS_cells:skin_fibroblast-derived: 0.23
NB11_TCAATCTTCCTTCAAT-1 Neurons:adrenal_medulla_cell_line 0.16 820.35
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:skin_fibroblast-derived: 0.13
NB11_GACACGCCATTAACCG-1 Neurons:adrenal_medulla_cell_line 0.17 712.51
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:skin_fibroblast-derived: 0.16
NB11_TGGTTCCGTCAAAGCG-1 Neurons:adrenal_medulla_cell_line 0.19 617.38
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.16, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, iPS_cells:PDB_2lox-22: 0.11
NB11_CGATGGCGTTTCCACC-1 Neurons:adrenal_medulla_cell_line 0.19 569.29
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_2lox-22: 0.16
NB11_GATCGATTCCAGAGGA-1 Neurons:adrenal_medulla_cell_line 0.19 427.36
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19, Embryonic_stem_cells: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:skin_fibroblast-derived: 0.13
NB11_ATCATCTGTTTGACAC-1 Neurons:adrenal_medulla_cell_line 0.18 412.11
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:skin_fibroblast-derived: 0.12
NB11_CGAGAAGTCCAGTATG-1 Neurons:adrenal_medulla_cell_line 0.13 408.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Neuroepithelial_cell:ESC-derived: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.13, Neurons:ES_cell-derived_neural_precursor: 0.13, Embryonic_stem_cells: 0.11, iPS_cells:PDB_1lox-17Puro-10: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, iPS_cells:PDB_1lox-21Puro-26: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.11, iPS_cells:skin_fibroblast-derived: 0.1
NB11_CACAGTATCATGCAAC-1 Neurons:adrenal_medulla_cell_line 0.19 406.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.2, Neuroepithelial_cell:ESC-derived: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_2lox-21: 0.15
NB11_CGTGAGCTCTTAGCCC-1 Neurons:adrenal_medulla_cell_line 0.14 369.98
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Neuroepithelial_cell:ESC-derived: 0.13, Astrocyte:Embryonic_stem_cell-derived: 0.13, Neurons:ES_cell-derived_neural_precursor: 0.12, Embryonic_stem_cells: 0.1, iPS_cells:PDB_1lox-17Puro-10: 0.09, iPS_cells:PDB_1lox-21Puro-20: 0.09, iPS_cells:PDB_1lox-21Puro-26: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.09, iPS_cells:skin_fibroblast-derived: 0.08
NB11_CTAGCCTGTTACGACT-1 Neurons:adrenal_medulla_cell_line 0.18 356.22
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.16, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:skin_fibroblast-derived: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11
NB11_TCATTTGGTCGCCATG-1 Neurons:adrenal_medulla_cell_line 0.17 353.33
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.17, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:skin_fibroblast-derived: 0.11
NB11_CTGTTTACATTAGGCT-1 Neurons:adrenal_medulla_cell_line 0.20 332.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, Embryonic_stem_cells: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.17, iPS_cells:PDB_2lox-22: 0.16
NB11_ATCGAGTAGCTAGTTC-1 Neurons:adrenal_medulla_cell_line 0.17 313.94
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.16, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.12, Tissue_stem_cells:CD326-CD56+: 0.12, iPS_cells:skin_fibroblast-derived: 0.12
NB11_TACAGTGAGCCACGCT-1 Neurons:adrenal_medulla_cell_line 0.13 296.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.13, Neuroepithelial_cell:ESC-derived: 0.13, Neurons:ES_cell-derived_neural_precursor: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.1, iPS_cells:PDB_1lox-21Puro-26: 0.1, iPS_cells:PDB_1lox-17Puro-10: 0.1, Embryonic_stem_cells: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.09, iPS_cells:skin_fibroblast-derived: 0.09
NB11_GCCAAATGTCAACTGT-1 Neurons:adrenal_medulla_cell_line 0.20 291.46
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.25, Neuroepithelial_cell:ESC-derived: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, iPS_cells:skin_fibroblast-derived: 0.16
NB11_TAGGCATGTCATGCCG-1 Neurons:adrenal_medulla_cell_line 0.15 274.70
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.16, Neuroepithelial_cell:ESC-derived: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.14, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.14, iPS_cells:PDB_1lox-17Puro-5: 0.14, iPS_cells:skin_fibroblast-derived: 0.13
NB11_CGGGTCAGTCGAAAGC-1 Neurons:adrenal_medulla_cell_line 0.17 267.27
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.24, Neuroepithelial_cell:ESC-derived: 0.2, Neurons:ES_cell-derived_neural_precursor: 0.2, Astrocyte:Embryonic_stem_cell-derived: 0.18, Embryonic_stem_cells: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:skin_fibroblast-derived: 0.16
NB11_CGTTCTGTCTGGTTCC-1 Neurons:adrenal_medulla_cell_line 0.13 260.92
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.12, Astrocyte:Embryonic_stem_cell-derived: 0.12, Neurons:ES_cell-derived_neural_precursor: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.09, iPS_cells:PDB_1lox-21Puro-26: 0.09, Embryonic_stem_cells: 0.09, iPS_cells:PDB_1lox-17Puro-10: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.09, iPS_cells:PDB_2lox-22: 0.08
NB11_TGTCCCAAGACAAAGG-1 Neurons:adrenal_medulla_cell_line 0.18 256.32
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.25, Neurons:ES_cell-derived_neural_precursor: 0.23, Astrocyte:Embryonic_stem_cell-derived: 0.22, iPS_cells:PDB_1lox-21Puro-20: 0.22, iPS_cells:PDB_1lox-17Puro-10: 0.22, iPS_cells:PDB_1lox-21Puro-26: 0.22, iPS_cells:PDB_1lox-17Puro-5: 0.22, Embryonic_stem_cells: 0.21, iPS_cells:PDB_2lox-22: 0.21
NB11_CGTTAGAGTGTTCTTT-1 Neurons:adrenal_medulla_cell_line 0.17 248.61
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.16, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:skin_fibroblast-derived: 0.11
NB11_TTTGTCAGTTGGACCC-1 Neurons:adrenal_medulla_cell_line 0.17 245.40
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.14, Embryonic_stem_cells: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.11, iPS_cells:PDB_1lox-17Puro-10: 0.11, iPS_cells:PDB_1lox-21Puro-26: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11, iPS_cells:skin_fibroblast-derived: 0.1
NB11_TTAGGCACATACAGCT-1 Neurons:adrenal_medulla_cell_line 0.16 244.59
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.21, Neuroepithelial_cell:ESC-derived: 0.17, Neurons:ES_cell-derived_neural_precursor: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.16, Embryonic_stem_cells: 0.14, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:skin_fibroblast-derived: 0.12
NB11_ATGGGAGGTTAAAGTG-1 Neurons:adrenal_medulla_cell_line 0.19 234.69
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.27, Neuroepithelial_cell:ESC-derived: 0.23, Neurons:ES_cell-derived_neural_precursor: 0.21, Astrocyte:Embryonic_stem_cell-derived: 0.21, Embryonic_stem_cells: 0.19, Tissue_stem_cells:CD326-CD56+: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.18, iPS_cells:PDB_1lox-17Puro-10: 0.18, iPS_cells:PDB_2lox-22: 0.18
NB11_CCGTGGATCTTTAGGG-1 Neurons:adrenal_medulla_cell_line 0.18 234.57
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:skin_fibroblast-derived: 0.12
NB11_ACATACGCACATCCAA-1 Neurons:adrenal_medulla_cell_line 0.17 233.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.2, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.15, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_2lox-22: 0.12
NB11_CATATTCAGGACGAAA-1 Neurons:adrenal_medulla_cell_line 0.15 231.72
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:skin_fibroblast-derived: 0.12
NB11_TTTGTCAGTTTCCACC-1 Neurons:adrenal_medulla_cell_line 0.13 230.37
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.12, Astrocyte:Embryonic_stem_cell-derived: 0.12, Neurons:ES_cell-derived_neural_precursor: 0.11, Embryonic_stem_cells: 0.1, iPS_cells:PDB_1lox-21Puro-20: 0.09, iPS_cells:PDB_1lox-21Puro-26: 0.09, iPS_cells:PDB_1lox-17Puro-10: 0.09, Tissue_stem_cells:CD326-CD56+: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.09
NB11_GGGAGATCAAGAGGCT-1 Neurons:adrenal_medulla_cell_line 0.12 222.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.12, Neurons:ES_cell-derived_neural_precursor: 0.12, Astrocyte:Embryonic_stem_cell-derived: 0.12, Embryonic_stem_cells: 0.1, iPS_cells:PDB_1lox-21Puro-20: 0.1, iPS_cells:PDB_1lox-17Puro-10: 0.1, iPS_cells:PDB_1lox-21Puro-26: 0.1, iPS_cells:PDB_1lox-17Puro-5: 0.1, iPS_cells:PDB_2lox-22: 0.09
NB11_CAGATCACACTGTCGG-1 Neurons:adrenal_medulla_cell_line 0.14 215.56
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Astrocyte:Embryonic_stem_cell-derived: 0.14, Neuroepithelial_cell:ESC-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, Embryonic_stem_cells: 0.12, iPS_cells:skin_fibroblast-derived: 0.12
NB11_CGTAGGCCACGGTGTC-1 Neurons:adrenal_medulla_cell_line 0.13 204.42
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.13, Neurons:ES_cell-derived_neural_precursor: 0.1, Neuroepithelial_cell:ESC-derived: 0.1, Astrocyte:Embryonic_stem_cell-derived: 0.1, Embryonic_stem_cells: 0.07, iPS_cells:PDB_2lox-5: 0.06, iPS_cells:PDB_2lox-22: 0.06, iPS_cells:PDB_1lox-17Puro-10: 0.06, iPS_cells:PDB_1lox-21Puro-20: 0.06, iPS_cells:PDB_1lox-21Puro-26: 0.06
NB11_CAAGTTGTCTGGTATG-1 Neurons:adrenal_medulla_cell_line 0.13 194.16
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.13, Neuroepithelial_cell:ESC-derived: 0.11, Neurons:ES_cell-derived_neural_precursor: 0.11, Astrocyte:Embryonic_stem_cell-derived: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.09, iPS_cells:PDB_1lox-21Puro-26: 0.09, iPS_cells:PDB_1lox-17Puro-10: 0.09, Embryonic_stem_cells: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.09, iPS_cells:skin_fibroblast-derived: 0.08
NB11_ACGCCAGAGAGCAATT-1 Neurons:adrenal_medulla_cell_line 0.13 188.24
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.14, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_2lox-17: 0.13
NB11_GCTGCAGAGGCTATCT-1 Neurons:adrenal_medulla_cell_line 0.13 186.68
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Astrocyte:Embryonic_stem_cell-derived: 0.12, Neuroepithelial_cell:ESC-derived: 0.11, Neurons:ES_cell-derived_neural_precursor: 0.1, iPS_cells:PDB_1lox-21Puro-20: 0.08, Embryonic_stem_cells: 0.08, iPS_cells:PDB_2lox-22: 0.08, iPS_cells:PDB_1lox-21Puro-26: 0.08, iPS_cells:PDB_1lox-17Puro-10: 0.08, iPS_cells:PDB_1lox-17Puro-5: 0.08
NB12_CACCACTAGCCACGCT-1 Neurons:adrenal_medulla_cell_line 0.16 179.45
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.18, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:PDB_1lox-21Puro-26: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:skin_fibroblast-derived: 0.15
NB11_ATTATCCTCACCCTCA-1 Neurons:adrenal_medulla_cell_line 0.18 179.08
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.23, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.19, Astrocyte:Embryonic_stem_cell-derived: 0.18, iPS_cells:PDB_1lox-21Puro-20: 0.17, iPS_cells:PDB_1lox-21Puro-26: 0.17, iPS_cells:PDB_1lox-17Puro-10: 0.17, iPS_cells:PDB_1lox-17Puro-5: 0.17, Embryonic_stem_cells: 0.16, iPS_cells:PDB_2lox-22: 0.16
NB11_CACAGTATCATTCACT-1 Neurons:adrenal_medulla_cell_line 0.14 173.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.14, Neuroepithelial_cell:ESC-derived: 0.1, Astrocyte:Embryonic_stem_cell-derived: 0.09, Neurons:ES_cell-derived_neural_precursor: 0.09, Embryonic_stem_cells: 0.08, iPS_cells:PDB_1lox-17Puro-10: 0.08, iPS_cells:PDB_1lox-21Puro-20: 0.08, iPS_cells:PDB_1lox-17Puro-5: 0.08, iPS_cells:PDB_1lox-21Puro-26: 0.07, iPS_cells:skin_fibroblast-derived: 0.07
NB11_ACGATACTCGCTGATA-1 Neurons:adrenal_medulla_cell_line 0.14 173.23
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Neurons:ES_cell-derived_neural_precursor: 0.14, Neuroepithelial_cell:ESC-derived: 0.13, Astrocyte:Embryonic_stem_cell-derived: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:skin_fibroblast-derived: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.11, Embryonic_stem_cells: 0.11
NB11_GGATGTTCACGAAAGC-1 Neurons:adrenal_medulla_cell_line 0.14 171.55
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, Neuroepithelial_cell:ESC-derived: 0.14, Neurons:ES_cell-derived_neural_precursor: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:skin_fibroblast-derived: 0.11
NB11_CCACTACAGACCACGA-1 Neurons:adrenal_medulla_cell_line 0.16 171.07
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.22, Neuroepithelial_cell:ESC-derived: 0.19, Neurons:ES_cell-derived_neural_precursor: 0.18, iPS_cells:PDB_1lox-21Puro-26: 0.16, iPS_cells:PDB_1lox-17Puro-10: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.16, iPS_cells:PDB_1lox-21Puro-20: 0.16, Embryonic_stem_cells: 0.16, iPS_cells:PDB_1lox-17Puro-5: 0.16, iPS_cells:skin_fibroblast-derived: 0.16
NB11_AACTTTCAGACTGGGT-1 Neurons:adrenal_medulla_cell_line 0.13 167.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.12, Neurons:ES_cell-derived_neural_precursor: 0.11, Astrocyte:Embryonic_stem_cell-derived: 0.11, iPS_cells:PDB_1lox-21Puro-20: 0.1, iPS_cells:PDB_1lox-21Puro-26: 0.09, iPS_cells:PDB_1lox-17Puro-10: 0.09, Embryonic_stem_cells: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.09, iPS_cells:skin_fibroblast-derived: 0.09
NB11_TATTACCTCCAGGGCT-1 Neurons:adrenal_medulla_cell_line 0.16 161.78
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.19, Neuroepithelial_cell:ESC-derived: 0.16, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-17Puro-10: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.12, iPS_cells:skin_fibroblast-derived: 0.12
NB11_CCCAGTTGTCTGGAGA-1 Neurons:adrenal_medulla_cell_line 0.13 159.54
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.15, Neuroepithelial_cell:ESC-derived: 0.11, Astrocyte:Embryonic_stem_cell-derived: 0.11, Neurons:ES_cell-derived_neural_precursor: 0.1, iPS_cells:PDB_1lox-21Puro-20: 0.09, Embryonic_stem_cells: 0.09, iPS_cells:PDB_1lox-21Puro-26: 0.09, iPS_cells:PDB_1lox-17Puro-5: 0.08, iPS_cells:PDB_1lox-17Puro-10: 0.08, iPS_cells:skin_fibroblast-derived: 0.08
NB11_ATAACGCAGTACTTGC-1 Neurons:adrenal_medulla_cell_line 0.15 154.85
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.16, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.14, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.12, iPS_cells:PDB_1lox-21Puro-26: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:PDB_1lox-17Puro-5: 0.11, iPS_cells:skin_fibroblast-derived: 0.11
NB11_TGGCGCAGTCGGCTCA-1 Neurons:adrenal_medulla_cell_line 0.10 147.87
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.09, Neuroepithelial_cell:ESC-derived: 0.06, Neurons:ES_cell-derived_neural_precursor: 0.05, Astrocyte:Embryonic_stem_cell-derived: 0.04, iPS_cells:PDB_1lox-21Puro-20: 0.03, Embryonic_stem_cells: 0.03, iPS_cells:PDB_1lox-17Puro-10: 0.03, iPS_cells:PDB_1lox-21Puro-26: 0.03, iPS_cells:skin_fibroblast-derived: 0.03, iPS_cells:PDB_1lox-17Puro-5: 0.02
NB11_GAACATCCAATTGCTG-1 Neurons:adrenal_medulla_cell_line 0.14 145.03
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.18, Neuroepithelial_cell:ESC-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.14, Astrocyte:Embryonic_stem_cell-derived: 0.13, Embryonic_stem_cells: 0.12, iPS_cells:PDB_1lox-17Puro-10: 0.12, iPS_cells:skin_fibroblast-derived: 0.12, iPS_cells:PDB_1lox-21Puro-20: 0.11, iPS_cells:PDB_1lox-21Puro-26: 0.11, iPS_cells:PDB_1lox-17Puro-5: 0.11
NB11_ACTGTCCAGGCAAAGA-1 Neurons:adrenal_medulla_cell_line 0.14 138.07
Raw ScoresNeurons:adrenal_medulla_cell_line: 0.17, Neuroepithelial_cell:ESC-derived: 0.17, Astrocyte:Embryonic_stem_cell-derived: 0.15, Neurons:ES_cell-derived_neural_precursor: 0.15, iPS_cells:PDB_1lox-17Puro-5: 0.13, iPS_cells:PDB_1lox-17Puro-10: 0.13, Embryonic_stem_cells: 0.13, iPS_cells:PDB_1lox-21Puro-26: 0.13, iPS_cells:PDB_1lox-21Puro-20: 0.13, iPS_cells:PDB_2lox-22: 0.12


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Stromal 1 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.38e-03
Mean rank of genes in gene set: 2687
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CHD3 0.0006014 727 GTEx DepMap Descartes 0.43 116.78
NFIB 0.0005360 852 GTEx DepMap Descartes 1.28 251.70
IGSF3 0.0003406 1485 GTEx DepMap Descartes 0.15 51.35
HMGA2 0.0003108 1629 GTEx DepMap Descartes 0.01 2.81
TGFB2 0.0002353 2088 GTEx DepMap Descartes 0.05 21.48
COL27A1 0.0000204 4797 GTEx DepMap Descartes 0.00 0.00
MMP14 -0.0000734 7231 GTEx DepMap Descartes 0.03 9.61


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.81e-03
Mean rank of genes in gene set: 5000.73
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
VCAN 0.0036891 42 GTEx DepMap Descartes 0.70 108.69
COL4A1 0.0011554 276 GTEx DepMap Descartes 0.23 60.09
MYH11 0.0005611 797 GTEx DepMap Descartes 0.11 31.80
TNC 0.0005397 845 GTEx DepMap Descartes 0.14 52.82
ACTA2 0.0003521 1433 GTEx DepMap Descartes 0.09 132.46
COL14A1 0.0002559 1936 GTEx DepMap Descartes 0.05 18.10
TGFB2 0.0002353 2088 GTEx DepMap Descartes 0.05 21.48
IGFBP7 0.0002212 2190 GTEx DepMap Descartes 0.27 374.92
COL11A1 0.0002206 2194 GTEx DepMap Descartes 0.13 25.51
COL5A2 0.0002157 2226 GTEx DepMap Descartes 0.13 29.09
COL15A1 0.0001977 2392 GTEx DepMap Descartes 0.03 12.06
TGFB1 0.0001794 2565 GTEx DepMap Descartes 0.11 91.96
ITGA7 0.0001785 2571 GTEx DepMap Descartes 0.01 1.82
COL5A1 0.0001603 2753 GTEx DepMap Descartes 0.09 18.15
HOPX 0.0001537 2823 GTEx DepMap Descartes 0.02 10.42
MMP2 0.0001268 3107 GTEx DepMap Descartes 0.11 46.43
COL12A1 0.0000979 3500 GTEx DepMap Descartes 0.09 10.37
CNN2 0.0000888 3615 GTEx DepMap Descartes 0.00 0.00
ACTG2 0.0000851 3664 GTEx DepMap Descartes 0.01 9.58
BGN 0.0000803 3735 GTEx DepMap Descartes 0.05 44.47
MMP11 0.0000745 3835 GTEx DepMap Descartes 0.02 4.47
COL1A1 0.0000686 3933 GTEx DepMap Descartes 0.40 128.84
MYL9 0.0000680 3946 GTEx DepMap Descartes 0.03 34.52
POSTN 0.0000599 4080 GTEx DepMap Descartes 0.08 48.15
MYLK 0.0000563 4147 GTEx DepMap Descartes 0.02 7.10
DCN 0.0000297 4607 GTEx DepMap Descartes 0.02 9.80
THBS2 0.0000099 5006 GTEx DepMap Descartes 0.09 24.15
THBS1 0.0000016 5187 GTEx DepMap Descartes 0.11 24.01
MEF2C -0.0000007 5237 GTEx DepMap Descartes 0.12 32.47
WNT5A -0.0000320 6043 GTEx DepMap Descartes 0.00 0.00
TGFBR1 -0.0000447 6420 GTEx DepMap Descartes 0.18 50.69
COL1A2 -0.0000487 6519 GTEx DepMap Descartes 0.43 113.62
THY1 -0.0000649 6993 GTEx DepMap Descartes 0.07 22.38
TAGLN -0.0000658 7011 GTEx DepMap Descartes 0.04 27.11
COL8A1 -0.0000672 7055 GTEx DepMap Descartes 0.05 13.56
TPM2 -0.0000682 7098 GTEx DepMap Descartes 0.06 54.93
IGFBP3 -0.0000735 7235 GTEx DepMap Descartes 0.01 4.33
LUM -0.0000809 7461 GTEx DepMap Descartes 0.03 16.93
COL13A1 -0.0000829 7511 GTEx DepMap Descartes 0.00 0.00
FN1 -0.0000932 7804 GTEx DepMap Descartes 0.30 53.75
TGFBR2 -0.0001051 8138 GTEx DepMap Descartes 0.03 6.73
TPM1 -0.0001096 8243 GTEx DepMap Descartes 0.19 62.50
COL10A1 -0.0001151 8397 GTEx DepMap Descartes 0.00 0.00
TMEM119 -0.0001159 8414 GTEx DepMap Descartes 0.00 0.00
COL3A1 -0.0001187 8477 GTEx DepMap Descartes 0.14 45.59
VEGFA -0.0001405 8945 GTEx DepMap Descartes 0.05 7.28
PGF -0.0001540 9216 GTEx DepMap Descartes 0.02 15.06
CNN3 -0.0002694 10895 GTEx DepMap Descartes 0.07 78.93
RGS5 -0.0008674 12431 GTEx DepMap Descartes 0.09 15.65


Endothelial Cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.49e-02
Mean rank of genes in gene set: 1249
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
ENG 0.0004840 965 GTEx DepMap Descartes 0.12 101.22
VWF 0.0003293 1533 GTEx DepMap Descartes 0.05 15.93




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 6755.7
Median rank of genes in gene set: 7476
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLIT3 0.0066896 13 GTEx DepMap Descartes 5.47 1218.03
ALK 0.0052722 23 GTEx DepMap Descartes 8.08 2734.65
PBX3 0.0031410 51 GTEx DepMap Descartes 2.22 1430.27
MSI2 0.0030487 53 GTEx DepMap Descartes 3.17 850.48
MAGI3 0.0026152 66 GTEx DepMap Descartes 1.36 446.68
NMNAT2 0.0023906 82 GTEx DepMap Descartes 1.28 489.61
PPM1E 0.0023501 88 GTEx DepMap Descartes 2.09 657.66
GNG4 0.0022462 93 GTEx DepMap Descartes 2.07 960.09
CACNA1B 0.0021425 100 GTEx DepMap Descartes 2.05 461.50
HS6ST2 0.0018883 125 GTEx DepMap Descartes 1.47 676.33
MARCH11 0.0017604 133 GTEx DepMap Descartes 1.39 NA
UNC79 0.0015417 168 GTEx DepMap Descartes 1.30 290.93
FAM163A 0.0014593 186 GTEx DepMap Descartes 1.59 1232.22
SV2C 0.0014353 190 GTEx DepMap Descartes 0.74 127.49
GABRB3 0.0014033 199 GTEx DepMap Descartes 0.91 327.94
CADM1 0.0013891 202 GTEx DepMap Descartes 2.39 529.61
TIAM1 0.0013028 223 GTEx DepMap Descartes 1.08 307.20
RIMBP2 0.0012956 226 GTEx DepMap Descartes 1.52 545.55
MAPT 0.0012382 246 GTEx DepMap Descartes 1.09 359.37
EYA1 0.0012323 249 GTEx DepMap Descartes 1.18 670.24
ELAVL3 0.0012063 259 GTEx DepMap Descartes 0.89 428.12
RBMS3 0.0011713 272 GTEx DepMap Descartes 3.87 793.00
KLHL13 0.0011254 282 GTEx DepMap Descartes 1.69 602.60
ST3GAL6 0.0011045 292 GTEx DepMap Descartes 0.41 213.71
CHML 0.0010942 298 GTEx DepMap Descartes 0.14 28.29
SHC3 0.0010914 301 GTEx DepMap Descartes 0.29 73.36
RPS6KA2 0.0010550 321 GTEx DepMap Descartes 0.34 123.53
AUTS2 0.0010542 322 GTEx DepMap Descartes 7.51 1939.66
RNF144A 0.0010536 324 GTEx DepMap Descartes 0.41 132.36
PHF21B 0.0010355 333 GTEx DepMap Descartes 0.30 174.95


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.69e-01
Mean rank of genes in gene set: 6169.71
Median rank of genes in gene set: 5915
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PTPRG 0.0039831 36 GTEx DepMap Descartes 1.38 324.84
BNC2 0.0025655 69 GTEx DepMap Descartes 0.64 88.49
DDR2 0.0024201 80 GTEx DepMap Descartes 0.40 89.91
COL4A2 0.0019803 110 GTEx DepMap Descartes 0.49 183.92
ANTXR1 0.0019561 112 GTEx DepMap Descartes 0.34 86.84
SEMA3C 0.0018959 122 GTEx DepMap Descartes 0.32 120.11
PDIA6 0.0017417 137 GTEx DepMap Descartes 1.81 1168.91
FBN2 0.0013877 205 GTEx DepMap Descartes 0.07 8.19
KCNK2 0.0013795 207 GTEx DepMap Descartes 0.05 38.89
COL4A1 0.0011554 276 GTEx DepMap Descartes 0.23 60.09
LPP 0.0008794 434 GTEx DepMap Descartes 0.66 56.87
MAML2 0.0008655 442 GTEx DepMap Descartes 0.42 121.34
PLXDC2 0.0008574 447 GTEx DepMap Descartes 0.44 55.50
FZD7 0.0008510 451 GTEx DepMap Descartes 0.03 17.57
PTGFRN 0.0008091 483 GTEx DepMap Descartes 0.09 29.06
SEC14L1 0.0007269 563 GTEx DepMap Descartes 0.24 109.10
CTSC 0.0006609 635 GTEx DepMap Descartes 0.07 22.35
ACAP2 0.0006588 637 GTEx DepMap Descartes 0.47 115.47
DMD 0.0006544 643 GTEx DepMap Descartes 0.88 114.68
SH3BGRL 0.0006277 683 GTEx DepMap Descartes 0.09 114.39
MRC2 0.0006259 687 GTEx DepMap Descartes 0.11 30.64
IQGAP2 0.0006215 694 GTEx DepMap Descartes 0.14 44.54
SDC2 0.0006145 705 GTEx DepMap Descartes 0.10 45.20
GPR137B 0.0006129 708 GTEx DepMap Descartes 0.16 174.34
FZD2 0.0006091 715 GTEx DepMap Descartes 0.02 6.86
CBLB 0.0005991 733 GTEx DepMap Descartes 0.39 119.10
BMP5 0.0005494 826 GTEx DepMap Descartes 0.01 13.96
TNC 0.0005397 845 GTEx DepMap Descartes 0.14 52.82
HS3ST3A1 0.0005382 849 GTEx DepMap Descartes 0.06 21.21
ADAM19 0.0005235 878 GTEx DepMap Descartes 0.15 61.04


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.41e-01
Mean rank of genes in gene set: 6492.86
Median rank of genes in gene set: 6465.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SH3PXD2B 0.0009505 390 GTEx DepMap Descartes 0.20 57.82
SLC1A2 0.0007210 569 GTEx DepMap Descartes 0.32 52.22
SGCZ 0.0006767 611 GTEx DepMap Descartes 0.33 82.78
FRMD5 0.0006721 618 GTEx DepMap Descartes 0.97 364.39
GRAMD1B 0.0004933 945 GTEx DepMap Descartes 0.13 38.83
JAKMIP2 0.0004085 1193 GTEx DepMap Descartes 0.44 99.67
SCARB1 0.0003708 1350 GTEx DepMap Descartes 0.19 87.11
NPC1 0.0002681 1863 GTEx DepMap Descartes 0.10 47.87
INHA 0.0001902 2458 GTEx DepMap Descartes 0.01 15.18
SLC16A9 0.0001231 3151 GTEx DepMap Descartes 0.11 50.16
IGF1R 0.0001205 3186 GTEx DepMap Descartes 0.66 103.11
LDLR 0.0001166 3233 GTEx DepMap Descartes 0.07 28.20
SH3BP5 0.0001064 3383 GTEx DepMap Descartes 0.09 51.29
BAIAP2L1 0.0000758 3811 GTEx DepMap Descartes 0.01 5.52
SCAP 0.0000397 4448 GTEx DepMap Descartes 0.11 48.90
FDX1 0.0000344 4536 GTEx DepMap Descartes 0.05 27.19
APOC1 0.0000080 5041 GTEx DepMap Descartes 0.05 113.65
ERN1 -0.0000134 5557 GTEx DepMap Descartes 0.05 16.91
STAR -0.0000781 7374 GTEx DepMap Descartes 0.00 0.00
FREM2 -0.0001017 8057 GTEx DepMap Descartes 0.01 2.79
FDPS -0.0001335 8818 GTEx DepMap Descartes 0.24 210.64
PEG3 -0.0001398 8932 GTEx DepMap Descartes 0.08 NA
PAPSS2 -0.0001420 8976 GTEx DepMap Descartes 0.04 22.15
FDXR -0.0001810 9725 GTEx DepMap Descartes 0.04 22.52
DHCR24 -0.0001856 9807 GTEx DepMap Descartes 0.03 12.56
DNER -0.0002192 10324 GTEx DepMap Descartes 0.06 43.39
TM7SF2 -0.0002367 10546 GTEx DepMap Descartes 0.02 36.02
DHCR7 -0.0002818 10992 GTEx DepMap Descartes 0.01 6.25
CYB5B -0.0003122 11256 GTEx DepMap Descartes 0.09 53.12
GSTA4 -0.0003277 11375 GTEx DepMap Descartes 0.11 97.03


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 7737.07
Median rank of genes in gene set: 10311
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ALK 0.0052722 23 GTEx DepMap Descartes 8.08 2734.65
EPHA6 0.0046598 29 GTEx DepMap Descartes 3.04 1286.23
MARCH11 0.0017604 133 GTEx DepMap Descartes 1.39 NA
EYA1 0.0012323 249 GTEx DepMap Descartes 1.18 670.24
RPH3A 0.0010909 302 GTEx DepMap Descartes 0.11 30.36
SLC44A5 0.0010201 343 GTEx DepMap Descartes 0.84 338.56
REEP1 0.0010069 347 GTEx DepMap Descartes 0.39 203.20
FAT3 0.0009625 383 GTEx DepMap Descartes 0.27 28.60
HS3ST5 0.0008478 452 GTEx DepMap Descartes 0.74 364.23
PLXNA4 0.0006808 608 GTEx DepMap Descartes 0.16 24.47
ANKFN1 0.0002954 1713 GTEx DepMap Descartes 0.10 46.72
PTCHD1 0.0001744 2619 GTEx DepMap Descartes 0.18 29.47
MAB21L1 0.0000837 3688 GTEx DepMap Descartes 0.11 101.98
GAP43 0.0000163 4866 GTEx DepMap Descartes 0.44 532.42
CNTFR 0.0000127 4943 GTEx DepMap Descartes 0.13 178.72
KCNB2 0.0000077 5047 GTEx DepMap Descartes 0.51 256.67
SYNPO2 -0.0001025 8082 GTEx DepMap Descartes 0.53 56.00
GREM1 -0.0001171 8439 GTEx DepMap Descartes 0.00 0.00
BASP1 -0.0001593 9336 GTEx DepMap Descartes 0.67 720.35
CNKSR2 -0.0002027 10083 GTEx DepMap Descartes 0.20 46.47
TMEFF2 -0.0002181 10311 GTEx DepMap Descartes 0.07 39.33
MAP1B -0.0003338 11415 GTEx DepMap Descartes 1.35 194.97
NTRK1 -0.0003619 11571 GTEx DepMap Descartes 0.03 14.26
RBFOX1 -0.0003932 11735 GTEx DepMap Descartes 1.71 709.16
GAL -0.0005339 12122 GTEx DepMap Descartes 0.44 1038.08
RGMB -0.0005577 12168 GTEx DepMap Descartes 0.06 24.27
RYR2 -0.0005591 12171 GTEx DepMap Descartes 1.36 140.44
SLC6A2 -0.0006692 12315 GTEx DepMap Descartes 0.10 71.81
ELAVL2 -0.0006728 12320 GTEx DepMap Descartes 0.33 183.14
EYA4 -0.0006885 12331 GTEx DepMap Descartes 0.80 263.22


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.18e-02
Mean rank of genes in gene set: 5320.08
Median rank of genes in gene set: 4447.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHRM3 0.0077571 9 GTEx DepMap Descartes 4.87 1033.01
ESM1 0.0011476 278 GTEx DepMap Descartes 0.02 14.58
PTPRB 0.0004725 990 GTEx DepMap Descartes 0.18 31.56
CDH13 0.0004539 1043 GTEx DepMap Descartes 0.08 20.38
PLVAP 0.0002160 2224 GTEx DepMap Descartes 0.02 38.33
MYRIP 0.0001954 2417 GTEx DepMap Descartes 0.12 38.70
BTNL9 0.0001791 2567 GTEx DepMap Descartes 0.00 0.00
EHD3 0.0001782 2577 GTEx DepMap Descartes 0.01 6.72
SHE 0.0001690 2668 GTEx DepMap Descartes 0.01 1.11
SLCO2A1 0.0001485 2880 GTEx DepMap Descartes 0.00 0.00
NR5A2 0.0001441 2920 GTEx DepMap Descartes 0.01 1.53
ROBO4 0.0001354 3005 GTEx DepMap Descartes 0.00 0.00
IRX3 0.0001070 3371 GTEx DepMap Descartes 0.00 0.00
KDR 0.0001065 3382 GTEx DepMap Descartes 0.00 0.00
RASIP1 0.0000638 4012 GTEx DepMap Descartes 0.01 14.21
NPR1 0.0000614 4056 GTEx DepMap Descartes 0.01 2.98
TIE1 0.0000482 4298 GTEx DepMap Descartes 0.01 13.35
CDH5 0.0000439 4373 GTEx DepMap Descartes 0.00 0.00
ARHGAP29 0.0000415 4416 GTEx DepMap Descartes 0.11 22.74
GALNT15 0.0000378 4479 GTEx DepMap Descartes 0.01 NA
CALCRL -0.0000059 5359 GTEx DepMap Descartes 0.01 1.25
CRHBP -0.0000093 5444 GTEx DepMap Descartes 0.00 0.00
FLT4 -0.0000103 5468 GTEx DepMap Descartes 0.00 0.00
PODXL -0.0000203 5728 GTEx DepMap Descartes 0.04 9.25
F8 -0.0000431 6365 GTEx DepMap Descartes 0.00 0.00
KANK3 -0.0000565 6731 GTEx DepMap Descartes 0.00 0.00
SHANK3 -0.0000663 7027 GTEx DepMap Descartes 0.01 1.57
MMRN2 -0.0000682 7100 GTEx DepMap Descartes 0.00 0.00
CLDN5 -0.0001059 8156 GTEx DepMap Descartes 0.00 0.00
NOTCH4 -0.0001134 8351 GTEx DepMap Descartes 0.01 0.70


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.08e-02
Mean rank of genes in gene set: 5256
Median rank of genes in gene set: 4531.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PRICKLE1 0.0018241 129 GTEx DepMap Descartes 0.72 234.93
PDGFRA 0.0017478 136 GTEx DepMap Descartes 0.15 53.08
DKK2 0.0007324 557 GTEx DepMap Descartes 0.03 11.83
ADAMTS2 0.0006175 704 GTEx DepMap Descartes 0.16 56.72
ACTA2 0.0003521 1433 GTEx DepMap Descartes 0.09 132.46
ADAMTSL3 0.0003515 1437 GTEx DepMap Descartes 0.03 3.31
PAMR1 0.0003401 1490 GTEx DepMap Descartes 0.05 32.52
ITGA11 0.0003143 1609 GTEx DepMap Descartes 0.05 10.89
GAS2 0.0002859 1764 GTEx DepMap Descartes 0.14 117.07
PCDH18 0.0002373 2075 GTEx DepMap Descartes 0.01 3.20
CDH11 0.0001510 2855 GTEx DepMap Descartes 0.13 28.27
COL12A1 0.0000979 3500 GTEx DepMap Descartes 0.09 10.37
EDNRA 0.0000845 3676 GTEx DepMap Descartes 0.02 3.62
ABCC9 0.0000755 3817 GTEx DepMap Descartes 0.02 3.37
LAMC3 0.0000752 3823 GTEx DepMap Descartes 0.01 6.54
C7 0.0000731 3857 GTEx DepMap Descartes 0.01 5.58
COL1A1 0.0000686 3933 GTEx DepMap Descartes 0.40 128.84
COL6A3 0.0000610 4067 GTEx DepMap Descartes 0.07 9.10
POSTN 0.0000599 4080 GTEx DepMap Descartes 0.08 48.15
PRRX1 0.0000538 4192 GTEx DepMap Descartes 0.02 9.87
ABCA6 0.0000417 4409 GTEx DepMap Descartes 0.04 8.20
GLI2 0.0000395 4456 GTEx DepMap Descartes 0.00 0.00
DCN 0.0000297 4607 GTEx DepMap Descartes 0.02 9.80
COL27A1 0.0000204 4797 GTEx DepMap Descartes 0.00 0.00
CLDN11 0.0000036 5133 GTEx DepMap Descartes 0.10 87.56
BICC1 -0.0000075 5400 GTEx DepMap Descartes 0.16 47.36
CD248 -0.0000436 6377 GTEx DepMap Descartes 0.02 10.80
COL1A2 -0.0000487 6519 GTEx DepMap Descartes 0.43 113.62
LOX -0.0000599 6842 GTEx DepMap Descartes 0.01 2.59
RSPO3 -0.0000705 7153 GTEx DepMap Descartes 0.00 NA


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.81e-01
Mean rank of genes in gene set: 6966.87
Median rank of genes in gene set: 8613
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FGF14 0.0046809 28 GTEx DepMap Descartes 8.44 1296.82
SORCS3 0.0039088 37 GTEx DepMap Descartes 0.26 88.06
GRM7 0.0028855 58 GTEx DepMap Descartes 0.72 322.01
NTNG1 0.0021223 101 GTEx DepMap Descartes 0.89 356.01
SLC35F3 0.0015888 159 GTEx DepMap Descartes 0.68 375.83
KCTD16 0.0015686 162 GTEx DepMap Descartes 1.24 186.82
TIAM1 0.0013028 223 GTEx DepMap Descartes 1.08 307.20
CDH12 0.0007331 555 GTEx DepMap Descartes 0.12 46.55
MGAT4C 0.0004647 1013 GTEx DepMap Descartes 0.26 9.96
TENM1 0.0004324 1101 GTEx DepMap Descartes 0.27 NA
KSR2 0.0002026 2345 GTEx DepMap Descartes 0.18 17.92
GRID2 0.0001560 2799 GTEx DepMap Descartes 0.04 17.94
UNC80 0.0001406 2951 GTEx DepMap Descartes 0.51 75.08
FAM155A 0.0001307 3053 GTEx DepMap Descartes 3.58 711.16
CCSER1 0.0001065 3380 GTEx DepMap Descartes 1.94 NA
DGKK -0.0000789 7400 GTEx DepMap Descartes 0.01 0.63
ROBO1 -0.0000871 7634 GTEx DepMap Descartes 0.39 62.18
SLC24A2 -0.0000928 7788 GTEx DepMap Descartes 0.03 7.08
LAMA3 -0.0001092 8235 GTEx DepMap Descartes 0.03 7.16
CNTN3 -0.0001425 8991 GTEx DepMap Descartes 0.01 1.54
GCH1 -0.0001477 9100 GTEx DepMap Descartes 0.16 106.33
PENK -0.0001629 9397 GTEx DepMap Descartes 0.00 0.00
AGBL4 -0.0002222 10371 GTEx DepMap Descartes 0.25 90.73
HTATSF1 -0.0002825 10995 GTEx DepMap Descartes 0.08 59.77
PCSK2 -0.0002841 11015 GTEx DepMap Descartes 0.09 43.80
ST18 -0.0002862 11040 GTEx DepMap Descartes 0.03 4.51
C1QL1 -0.0002930 11099 GTEx DepMap Descartes 0.01 21.46
PACRG -0.0003273 11372 GTEx DepMap Descartes 0.05 81.27
TBX20 -0.0003527 11525 GTEx DepMap Descartes 0.01 34.30
SLC18A1 -0.0003667 11601 GTEx DepMap Descartes 0.03 18.48


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.41e-03
Mean rank of genes in gene set: 4696.48
Median rank of genes in gene set: 3683
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TSPAN5 0.0007046 582 GTEx DepMap Descartes 0.67 355.99
SPTB 0.0006750 614 GTEx DepMap Descartes 0.14 32.19
ANK1 0.0004637 1015 GTEx DepMap Descartes 0.22 66.28
MARCH3 0.0004423 1073 GTEx DepMap Descartes 0.20 NA
TFR2 0.0003816 1299 GTEx DepMap Descartes 0.23 156.01
DENND4A 0.0002123 2271 GTEx DepMap Descartes 0.39 78.61
RGS6 0.0001575 2777 GTEx DepMap Descartes 0.01 3.22
EPB41 0.0001477 2891 GTEx DepMap Descartes 0.24 70.52
BLVRB 0.0001292 3073 GTEx DepMap Descartes 0.03 45.14
ABCB10 0.0001207 3179 GTEx DepMap Descartes 0.11 47.36
TRAK2 0.0001137 3278 GTEx DepMap Descartes 0.11 17.29
SLC25A37 0.0001015 3449 GTEx DepMap Descartes 0.09 30.27
MICAL2 0.0000975 3505 GTEx DepMap Descartes 0.05 11.13
SPECC1 0.0000933 3549 GTEx DepMap Descartes 0.03 11.11
CAT 0.0000839 3683 GTEx DepMap Descartes 0.08 68.61
SLC25A21 0.0000597 4085 GTEx DepMap Descartes 0.01 5.84
CPOX 0.0000475 4310 GTEx DepMap Descartes 0.03 14.66
GYPC 0.0000382 4472 GTEx DepMap Descartes 0.00 0.00
TMCC2 0.0000228 4751 GTEx DepMap Descartes 0.02 19.66
RHD -0.0000261 5896 GTEx DepMap Descartes 0.02 10.53
SLC4A1 -0.0000574 6759 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0000622 6915 GTEx DepMap Descartes 0.00 0.00
XPO7 -0.0000661 7020 GTEx DepMap Descartes 0.21 77.11
SNCA -0.0000670 7052 GTEx DepMap Descartes 0.09 45.79
FECH -0.0000984 7943 GTEx DepMap Descartes 0.01 2.12
SELENBP1 -0.0001257 8650 GTEx DepMap Descartes 0.00 0.00
GCLC -0.0001619 9375 GTEx DepMap Descartes 0.10 57.78
SOX6 -0.0002621 10821 GTEx DepMap Descartes 0.23 51.89
RAPGEF2 -0.0004447 11911 GTEx DepMap Descartes 0.21 35.72
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.42e-02
Mean rank of genes in gene set: 5117.26
Median rank of genes in gene set: 4284.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MSR1 0.0110912 5 GTEx DepMap Descartes 1.53 975.19
SFMBT2 0.0012609 239 GTEx DepMap Descartes 0.30 62.23
HRH1 0.0007671 525 GTEx DepMap Descartes 0.04 19.67
CTSC 0.0006609 635 GTEx DepMap Descartes 0.07 22.35
PTPRE 0.0004666 1001 GTEx DepMap Descartes 0.14 37.75
SPP1 0.0003142 1610 GTEx DepMap Descartes 0.02 11.64
ADAP2 0.0002444 2018 GTEx DepMap Descartes 0.07 37.49
CTSS 0.0001993 2368 GTEx DepMap Descartes 0.03 10.61
SLCO2B1 0.0001862 2499 GTEx DepMap Descartes 0.05 16.67
MARCH1 0.0001819 2538 GTEx DepMap Descartes 0.09 NA
SLC9A9 0.0001710 2643 GTEx DepMap Descartes 0.05 23.41
ABCA1 0.0001425 2938 GTEx DepMap Descartes 0.05 14.04
MERTK 0.0001307 3052 GTEx DepMap Descartes 0.05 11.48
CSF1R 0.0000810 3726 GTEx DepMap Descartes 0.01 7.11
TGFBI 0.0000694 3920 GTEx DepMap Descartes 0.05 5.68
LGMN 0.0000683 3942 GTEx DepMap Descartes 0.05 30.32
RBPJ 0.0000558 4154 GTEx DepMap Descartes 0.45 138.17
SLC1A3 0.0000529 4206 GTEx DepMap Descartes 0.02 11.74
HCK 0.0000528 4212 GTEx DepMap Descartes 0.03 41.74
CD163 0.0000449 4357 GTEx DepMap Descartes 0.00 0.00
ATP8B4 0.0000440 4371 GTEx DepMap Descartes 0.01 4.18
ITPR2 0.0000379 4478 GTEx DepMap Descartes 0.13 16.45
CD14 0.0000321 4566 GTEx DepMap Descartes 0.00 0.00
CTSB -0.0000094 5447 GTEx DepMap Descartes 0.13 83.64
CYBB -0.0000308 6004 GTEx DepMap Descartes 0.01 1.43
FGD2 -0.0000321 6046 GTEx DepMap Descartes 0.00 0.00
MS4A4A -0.0000646 6982 GTEx DepMap Descartes 0.00 0.00
RGL1 -0.0000650 6996 GTEx DepMap Descartes 0.14 55.89
CPVL -0.0000782 7381 GTEx DepMap Descartes 0.05 63.64
CTSD -0.0001105 8271 GTEx DepMap Descartes 0.09 91.17


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.91e-02
Mean rank of genes in gene set: 5145.11
Median rank of genes in gene set: 2320.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IL1RAPL1 0.0094500 8 GTEx DepMap Descartes 2.21 1098.85
NRXN1 0.0061656 16 GTEx DepMap Descartes 5.11 966.36
VCAN 0.0036891 42 GTEx DepMap Descartes 0.70 108.69
TRPM3 0.0022902 91 GTEx DepMap Descartes 0.22 29.82
FIGN 0.0016326 154 GTEx DepMap Descartes 0.38 80.39
SLC35F1 0.0015183 171 GTEx DepMap Descartes 0.20 54.31
PLCE1 0.0012586 240 GTEx DepMap Descartes 0.31 41.34
SCN7A 0.0010252 338 GTEx DepMap Descartes 0.32 78.40
PPP2R2B 0.0009311 401 GTEx DepMap Descartes 0.64 108.81
NRXN3 0.0007209 571 GTEx DepMap Descartes 0.31 52.21
ERBB4 0.0006462 654 GTEx DepMap Descartes 3.20 445.15
STARD13 0.0006328 671 GTEx DepMap Descartes 0.16 44.82
XKR4 0.0003758 1324 GTEx DepMap Descartes 0.22 22.88
GRIK3 0.0003644 1379 GTEx DepMap Descartes 0.04 7.99
HMGA2 0.0003108 1629 GTEx DepMap Descartes 0.01 2.81
SORCS1 0.0002990 1688 GTEx DepMap Descartes 0.82 152.74
GAS7 0.0002860 1762 GTEx DepMap Descartes 0.07 13.16
IL1RAPL2 0.0002318 2113 GTEx DepMap Descartes 0.07 58.97
ERBB3 0.0002237 2169 GTEx DepMap Descartes 0.00 0.00
COL25A1 0.0002179 2210 GTEx DepMap Descartes 0.01 3.21
COL5A2 0.0002157 2226 GTEx DepMap Descartes 0.13 29.09
EDNRB 0.0002137 2255 GTEx DepMap Descartes 0.00 0.00
ADAMTS5 0.0001980 2386 GTEx DepMap Descartes 0.03 8.08
LAMB1 -0.0000285 5942 GTEx DepMap Descartes 0.40 129.58
MDGA2 -0.0000351 6137 GTEx DepMap Descartes 0.00 0.00
MPZ -0.0000362 6168 GTEx DepMap Descartes 0.01 19.32
COL18A1 -0.0000412 6314 GTEx DepMap Descartes 0.10 20.12
LAMA4 -0.0001043 8119 GTEx DepMap Descartes 0.03 6.75
OLFML2A -0.0001239 8602 GTEx DepMap Descartes 0.00 0.00
LRRTM4 -0.0001303 8740 GTEx DepMap Descartes 0.31 92.58


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.16e-01
Mean rank of genes in gene set: 5851.44
Median rank of genes in gene set: 5187
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DOK6 0.0011249 283 GTEx DepMap Descartes 0.39 93.48
LIMS1 0.0003791 1312 GTEx DepMap Descartes 0.27 92.51
ARHGAP6 0.0003421 1475 GTEx DepMap Descartes 0.02 4.38
LTBP1 0.0003066 1653 GTEx DepMap Descartes 0.04 7.64
FLNA 0.0002867 1753 GTEx DepMap Descartes 0.27 67.95
TRPC6 0.0002254 2151 GTEx DepMap Descartes 0.02 11.63
GP1BA 0.0001883 2479 GTEx DepMap Descartes 0.03 14.43
PDE3A 0.0001803 2558 GTEx DepMap Descartes 0.59 135.34
TGFB1 0.0001794 2565 GTEx DepMap Descartes 0.11 91.96
SLC24A3 0.0001783 2574 GTEx DepMap Descartes 0.03 10.22
CD84 0.0001696 2657 GTEx DepMap Descartes 0.01 0.44
PSTPIP2 0.0001655 2698 GTEx DepMap Descartes 0.01 5.08
RAB27B 0.0001297 3069 GTEx DepMap Descartes 0.06 12.04
FLI1 0.0001136 3279 GTEx DepMap Descartes 0.05 5.76
GSN 0.0000983 3492 GTEx DepMap Descartes 0.09 32.68
MED12L 0.0000898 3603 GTEx DepMap Descartes 0.16 25.79
MYH9 0.0000590 4094 GTEx DepMap Descartes 0.11 25.72
MYLK 0.0000563 4147 GTEx DepMap Descartes 0.02 7.10
UBASH3B 0.0000432 4383 GTEx DepMap Descartes 0.03 8.74
ANGPT1 0.0000277 4656 GTEx DepMap Descartes 0.01 3.50
ITGB3 0.0000170 4858 GTEx DepMap Descartes 0.00 0.00
ACTN1 0.0000130 4936 GTEx DepMap Descartes 0.19 66.01
THBS1 0.0000016 5187 GTEx DepMap Descartes 0.11 24.01
TPM4 -0.0000178 5652 GTEx DepMap Descartes 0.17 60.38
TUBB1 -0.0000201 5720 GTEx DepMap Descartes 0.00 0.00
HIPK2 -0.0000597 6832 GTEx DepMap Descartes 0.39 60.92
FERMT3 -0.0000640 6965 GTEx DepMap Descartes 0.01 12.82
PLEK -0.0000686 7111 GTEx DepMap Descartes 0.00 0.00
STON2 -0.0000715 7173 GTEx DepMap Descartes 0.02 6.23
MMRN1 -0.0000719 7182 GTEx DepMap Descartes 0.00 0.00


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.62e-02
Mean rank of genes in gene set: 5080.69
Median rank of genes in gene set: 4358.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TOX 0.0020110 108 GTEx DepMap Descartes 1.99 931.74
PITPNC1 0.0019340 115 GTEx DepMap Descartes 1.39 432.76
BACH2 0.0010753 308 GTEx DepMap Descartes 1.02 208.74
FOXP1 0.0009490 391 GTEx DepMap Descartes 1.30 265.33
ANKRD44 0.0008978 414 GTEx DepMap Descartes 0.44 114.43
BCL2 0.0007535 532 GTEx DepMap Descartes 1.90 526.27
STK39 0.0007531 533 GTEx DepMap Descartes 0.55 309.57
CELF2 0.0007391 549 GTEx DepMap Descartes 0.22 56.24
FYN 0.0007209 570 GTEx DepMap Descartes 0.97 552.65
SCML4 0.0006972 592 GTEx DepMap Descartes 0.32 147.48
EVL 0.0005551 812 GTEx DepMap Descartes 0.95 592.09
ABLIM1 0.0004106 1186 GTEx DepMap Descartes 0.18 41.15
ARID5B 0.0003541 1419 GTEx DepMap Descartes 0.13 32.72
SAMD3 0.0003264 1541 GTEx DepMap Descartes 0.06 33.16
MBNL1 0.0003126 1620 GTEx DepMap Descartes 0.47 143.30
GNG2 0.0001731 2630 GTEx DepMap Descartes 0.28 130.35
SORL1 0.0001015 3450 GTEx DepMap Descartes 0.14 20.65
PRKCH 0.0000979 3502 GTEx DepMap Descartes 0.03 15.47
PLEKHA2 0.0000575 4122 GTEx DepMap Descartes 0.01 1.11
SP100 0.0000509 4252 GTEx DepMap Descartes 0.03 10.49
ITPKB 0.0000455 4351 GTEx DepMap Descartes 0.01 2.31
MSN 0.0000444 4366 GTEx DepMap Descartes 0.04 21.14
WIPF1 0.0000124 4948 GTEx DepMap Descartes 0.12 55.46
MCTP2 -0.0000044 5315 GTEx DepMap Descartes 0.01 4.57
ARHGDIB -0.0000138 5567 GTEx DepMap Descartes 0.01 11.17
PDE3B -0.0000276 5925 GTEx DepMap Descartes 0.29 92.34
NCALD -0.0000745 7268 GTEx DepMap Descartes 0.07 26.48
LEF1 -0.0000800 7433 GTEx DepMap Descartes 0.01 4.64
ETS1 -0.0000889 7679 GTEx DepMap Descartes 0.01 2.78
CCL5 -0.0000966 7899 GTEx DepMap Descartes 0.00 0.00


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.94e-02
Mean rank of genes in gene set: 1433
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
GRIN1 0.0009838 363 GTEx DepMap Descartes 0.49 256.79
KL 0.0001857 2503 GTEx DepMap Descartes 0.01 2.12


T cells: gamma-delta T cells (model markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.07e-02
Mean rank of genes in gene set: 2629.33
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
KCNK10 0.0015539 164 GTEx DepMap Descartes 0.29 66.93
GRIN1 0.0009838 363 GTEx DepMap Descartes 0.49 256.79
KLRC2 -0.0000776 7361 GTEx DepMap Descartes 0.00 0.00


HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-02
Mean rank of genes in gene set: 4
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CUX2 0.0114487 4 GTEx DepMap Descartes 5.02 1780.14