Program: 4. Macrophage.

Program: 4. Macrophage.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 GPNMB 0.0061595 glycoprotein nmb GTEx DepMap Descartes 6.33 519.13
2 CSTB 0.0060868 cystatin B GTEx DepMap Descartes 17.69 NA
3 CAPG 0.0058993 capping actin protein, gelsolin like GTEx DepMap Descartes 4.71 800.16
4 CTSD 0.0057705 cathepsin D GTEx DepMap Descartes 29.70 3587.56
5 APOC1 0.0056566 apolipoprotein C1 GTEx DepMap Descartes 55.54 16862.42
6 CD68 0.0052851 CD68 molecule GTEx DepMap Descartes 10.89 1376.90
7 ACP5 0.0052575 acid phosphatase 5, tartrate resistant GTEx DepMap Descartes 2.73 313.53
8 CYP27A1 0.0050977 cytochrome P450 family 27 subfamily A member 1 GTEx DepMap Descartes 0.77 61.44
9 CTSZ 0.0050173 cathepsin Z GTEx DepMap Descartes 9.29 1415.96
10 CTSB 0.0049809 cathepsin B GTEx DepMap Descartes 20.73 1419.88
11 PLA2G7 0.0049094 phospholipase A2 group VII GTEx DepMap Descartes 2.45 263.29
12 LGALS3 0.0047586 galectin 3 GTEx DepMap Descartes 7.38 832.92
13 SPP1 0.0044444 secreted phosphoprotein 1 GTEx DepMap Descartes 144.70 26388.04
14 MMP9 0.0043965 matrix metallopeptidase 9 GTEx DepMap Descartes 2.77 194.81
15 FUCA1 0.0041507 alpha-L-fucosidase 1 GTEx DepMap Descartes 2.76 243.01
16 NUPR1 0.0041446 nuclear protein 1, transcriptional regulator GTEx DepMap Descartes 2.45 102.53
17 PSAP 0.0040919 prosaposin GTEx DepMap Descartes 14.31 1010.83
18 PLIN2 0.0040535 perilipin 2 GTEx DepMap Descartes 5.91 870.36
19 NPL 0.0039520 N-acetylneuraminate pyruvate lyase GTEx DepMap Descartes 1.65 127.56
20 ATOX1 0.0039351 antioxidant 1 copper chaperone GTEx DepMap Descartes 6.56 301.35
21 APOE 0.0039245 apolipoprotein E GTEx DepMap Descartes 117.94 20862.80
22 S100A11 0.0038460 S100 calcium binding protein A11 GTEx DepMap Descartes 17.87 7468.96
23 LIPA 0.0038137 lipase A, lysosomal acid type GTEx DepMap Descartes 4.54 408.02
24 CTSL 0.0037686 cathepsin L GTEx DepMap Descartes 10.89 NA
25 GM2A 0.0037409 GM2 ganglioside activator GTEx DepMap Descartes 1.13 67.58
26 IL4I1 0.0037314 interleukin 4 induced 1 GTEx DepMap Descartes 1.09 105.41
27 IL18 0.0037261 interleukin 18 GTEx DepMap Descartes 2.04 241.73
28 NPC2 0.0037030 NPC intracellular cholesterol transporter 2 GTEx DepMap Descartes 10.18 1553.32
29 GRN 0.0036943 granulin precursor GTEx DepMap Descartes 8.99 852.20
30 OTOA 0.0035901 otoancorin GTEx DepMap Descartes 0.82 33.71
31 FTH1 0.0035559 ferritin heavy chain 1 GTEx DepMap Descartes 154.58 27938.67
32 FABP5 0.0035100 fatty acid binding protein 5 GTEx DepMap Descartes 14.69 3965.12
33 FCER1G 0.0034412 Fc epsilon receptor Ig GTEx DepMap Descartes 12.05 4724.51
34 RAB42 0.0033087 RAB42, member RAS oncogene family GTEx DepMap Descartes 0.75 80.14
35 CD63 0.0032765 CD63 molecule GTEx DepMap Descartes 14.41 2690.24
36 CTSH 0.0032761 cathepsin H GTEx DepMap Descartes 2.71 258.59
37 PRDX1 0.0031763 peroxiredoxin 1 GTEx DepMap Descartes 8.75 1438.08
38 LGALS1 0.0031371 galectin 1 GTEx DepMap Descartes 15.51 5512.11
39 CTSA 0.0031005 cathepsin A GTEx DepMap Descartes 2.38 180.41
40 GLUL 0.0030906 glutamate-ammonia ligase GTEx DepMap Descartes 7.11 221.48
41 ITGB2 0.0029971 integrin subunit beta 2 GTEx DepMap Descartes 3.72 177.53
42 CREG1 0.0029933 cellular repressor of E1A stimulated genes 1 GTEx DepMap Descartes 3.67 402.33
43 BLVRB 0.0029151 biliverdin reductase B GTEx DepMap Descartes 4.01 675.54
44 TYROBP 0.0028541 transmembrane immune signaling adaptor TYROBP GTEx DepMap Descartes 22.46 8139.71
45 ASAH1 0.0028095 N-acylsphingosine amidohydrolase 1 GTEx DepMap Descartes 5.24 197.41
46 CTSS 0.0028093 cathepsin S GTEx DepMap Descartes 6.25 304.47
47 MMP12 0.0027666 matrix metallopeptidase 12 GTEx DepMap Descartes 4.71 487.95
48 BRI3 0.0026749 brain protein I3 GTEx DepMap Descartes 6.09 429.80
49 VAMP8 0.0026413 vesicle associated membrane protein 8 GTEx DepMap Descartes 4.48 1252.79
50 CD84 0.0026399 CD84 molecule GTEx DepMap Descartes 1.09 29.32


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UMAP plots showing activity of gene expression program identified in GEP 4. Macrophage:

Interactive UMAP Plot
Interactive UMAP Plot
Interactive UMAP Plot
Interactive Boxplot
Interactive Boxplot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
TRAVAGLINI_LUNG_TREM2_DENDRITIC_CELL 8.57e-59 274.72 99.44 5.75e-56 5.75e-56
46GPNMB, CSTB, CAPG, CTSD, APOC1, CD68, ACP5, CYP27A1, CTSZ, CTSB, PLA2G7, LGALS3, SPP1, MMP9, FUCA1, NUPR1, PSAP, NPL, ATOX1, APOE, S100A11, LIPA, CTSL, GM2A, IL4I1, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, PRDX1, LGALS1, CTSA, GLUL, ITGB2, CREG1, BLVRB, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 572
TRAVAGLINI_LUNG_MACROPHAGE_CELL 1.16e-30 65.09 35.08 1.95e-28 7.81e-28
24GPNMB, CSTB, CAPG, CTSD, APOC1, ACP5, CTSB, LGALS3, NUPR1, PSAP, APOE, S100A11, CTSL, NPC2, GRN, FTH1, FABP5, FCER1G, CTSH, LGALS1, GLUL, TYROBP, ASAH1, CTSS
 201
FAN_EMBRYONIC_CTX_MICROGLIA_3 1.20e-08 92.39 25.13 3.51e-07 8.07e-06
5CTSD, CD68, CTSB, CREG1, ASAH1
 20
TRAVAGLINI_LUNG_PROLIFERATING_MACROPHAGE_CELL 1.87e-35 47.81 23.93 6.27e-33 1.25e-32
39GPNMB, CSTB, CAPG, CTSD, APOC1, CD68, ACP5, CYP27A1, CTSZ, CTSB, LGALS3, FUCA1, NUPR1, PSAP, PLIN2, ATOX1, APOE, S100A11, LIPA, CTSL, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, PRDX1, LGALS1, CTSA, GLUL, CREG1, BLVRB, TYROBP, ASAH1, CTSS, BRI3, VAMP8
 968
FAN_OVARY_CL13_MONOCYTE_MACROPHAGE 2.43e-31 43.84 23.87 5.43e-29 1.63e-28
30CSTB, CAPG, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, PSAP, PLIN2, ATOX1, S100A11, CTSL, IL4I1, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, PRDX1, LGALS1, ITGB2, BLVRB, TYROBP, ASAH1, CTSS, BRI3, VAMP8
 458
ZHONG_PFC_MAJOR_TYPES_MICROGLIA 1.16e-28 38.82 21.22 1.56e-26 7.78e-26
28CTSD, APOC1, CD68, CTSB, PLA2G7, SPP1, PSAP, NPL, APOE, S100A11, LIPA, CTSL, GM2A, NPC2, GRN, FCER1G, CD63, CTSA, GLUL, ITGB2, CREG1, BLVRB, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 438
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 1.36e-22 40.06 21.18 1.02e-20 9.12e-20
20GPNMB, CTSD, CTSB, PSAP, S100A11, LIPA, IL18, NPC2, GRN, FTH1, FCER1G, GLUL, ITGB2, CREG1, BLVRB, TYROBP, ASAH1, CTSS, VAMP8, CD84
 228
FAN_EMBRYONIC_CTX_BIG_GROUPS_MICROGLIA 2.90e-24 33.27 18.08 3.25e-22 1.95e-21
24CTSD, APOC1, CD68, CTSB, SPP1, PSAP, NPL, APOE, S100A11, LIPA, CTSL, GM2A, NPC2, GRN, FCER1G, CTSH, GLUL, ITGB2, CREG1, TYROBP, ASAH1, CTSS, VAMP8, CD84
 371
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 2.27e-17 31.95 16.17 1.52e-15 1.52e-14
16CTSB, PSAP, S100A11, LIPA, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CTSH, LGALS1, ITGB2, TYROBP, CTSS, CD84
 200
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MACROPHAGES 2.36e-11 38.04 15.67 1.05e-09 1.58e-08
9APOC1, CD68, APOE, NPC2, GRN, FCER1G, ITGB2, TYROBP, CTSS
 81
MANNO_MIDBRAIN_NEUROTYPES_HMGL 1.37e-22 24.60 13.48 1.02e-20 9.16e-20
26GPNMB, CAPG, CTSD, APOC1, CD68, CTSB, SPP1, NPL, APOE, LIPA, CTSL, GM2A, IL18, NPC2, GRN, FCER1G, CTSH, ITGB2, CREG1, BLVRB, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 577
MURARO_PANCREAS_DUCTAL_CELL 1.01e-22 19.56 10.55 9.68e-21 6.77e-20
33GPNMB, CSTB, CAPG, CTSD, CD68, ACP5, CTSB, PLA2G7, LGALS3, SPP1, FUCA1, PSAP, S100A11, LIPA, CTSL, GM2A, IL18, NPC2, GRN, FTH1, FCER1G, CD63, CTSH, PRDX1, GLUL, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 1276
HU_FETAL_RETINA_MICROGLIA 1.50e-15 19.33 10.11 8.40e-14 1.01e-12
18CTSD, CTSB, SPP1, PSAP, NPL, S100A11, LIPA, GM2A, NPC2, GRN, FCER1G, GLUL, ITGB2, CREG1, TYROBP, CTSS, VAMP8, CD84
 382
GAO_LARGE_INTESTINE_24W_C11_PANETH_LIKE_CELL 4.27e-14 19.04 9.71 2.20e-12 2.86e-11
16CD68, ACP5, CTSZ, PLA2G7, MMP9, PLIN2, NPL, LIPA, CTSL, GM2A, IL4I1, FCER1G, ITGB2, CREG1, TYROBP, CD84
 325
RUBENSTEIN_SKELETAL_MUSCLE_MYELOID_CELLS 1.15e-13 17.78 9.07 5.51e-12 7.71e-11
16CSTB, CD68, CTSZ, CTSB, PSAP, S100A11, NPC2, FTH1, FCER1G, CTSH, ITGB2, CREG1, TYROBP, ASAH1, CTSS, VAMP8
 347
DESCARTES_FETAL_CEREBELLUM_MICROGLIA 2.28e-16 15.85 8.59 1.39e-14 1.53e-13
22GPNMB, CAPG, APOC1, CD68, CTSZ, CTSB, PLA2G7, LGALS3, SPP1, NPL, APOE, CTSL, GM2A, IL4I1, IL18, FCER1G, ITGB2, CREG1, BLVRB, TYROBP, CTSS, CD84
 642
DESCARTES_FETAL_THYMUS_ANTIGEN_PRESENTING_CELLS 1.01e-09 19.28 8.45 3.57e-08 6.79e-07
10CD68, MMP9, FUCA1, IL4I1, IL18, FCER1G, CTSH, TYROBP, CTSS, CD84
 172
CUI_DEVELOPING_HEART_C8_MACROPHAGE 2.67e-11 16.77 8.08 1.12e-09 1.79e-08
13CTSD, CD68, CTSB, PSAP, NPC2, GRN, FCER1G, GLUL, ITGB2, CREG1, TYROBP, CTSS, VAMP8
 275
TRAVAGLINI_LUNG_NONCLASSICAL_MONOCYTE_CELL 1.57e-09 18.38 8.06 5.26e-08 1.05e-06
10PSAP, NPL, S100A11, NPC2, FTH1, FCER1G, TYROBP, ASAH1, CTSS, BRI3
 180
AIZARANI_LIVER_C25_KUPFFER_CELLS_4 2.11e-08 16.62 6.99 5.89e-07 1.41e-05
9PSAP, S100A11, NPC2, GRN, FTH1, FCER1G, ITGB2, TYROBP, CTSS
 174

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_COMPLEMENT 1.15e-11 20.99 9.83 5.75e-10 5.75e-10
12CTSD, APOC1, CTSB, PLA2G7, LGALS3, ATOX1, LIPA, CTSL, FCER1G, CTSH, CTSS, MMP12
 200
HALLMARK_KRAS_SIGNALING_UP 1.19e-05 10.54 3.95 2.97e-04 5.94e-04
7GPNMB, SPP1, MMP9, FUCA1, FCER1G, ITGB2, CTSS
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 3.11e-03 11.23 2.19 2.59e-02 1.56e-01
3LGALS3, S100A11, FABP5
 74
HALLMARK_P53_PATHWAY 1.08e-03 7.12 2.18 1.35e-02 5.40e-02
5CTSD, FUCA1, NUPR1, GM2A, VAMP8
 200
HALLMARK_ALLOGRAFT_REJECTION 1.08e-03 7.12 2.18 1.35e-02 5.40e-02
5CAPG, MMP9, IL18, ITGB2, CTSS
 200
HALLMARK_COAGULATION 2.09e-03 8.11 2.09 2.09e-02 1.05e-01
4APOC1, CTSB, MMP9, CTSH
 138
HALLMARK_IL2_STAT5_SIGNALING 7.58e-03 5.57 1.44 4.82e-02 3.79e-01
4CAPG, CTSZ, SPP1, PLIN2
 199
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 7.71e-03 5.55 1.44 4.82e-02 3.85e-01
4CAPG, SPP1, FUCA1, LGALS1
 200
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 1.61e-02 11.07 1.27 8.96e-02 8.06e-01
2ATOX1, PRDX1
 49
HALLMARK_FATTY_ACID_METABOLISM 2.41e-02 5.15 1.01 1.21e-01 1.00e+00
3IL4I1, LGALS1, GLUL
 158
HALLMARK_MTORC1_SIGNALING 4.35e-02 4.05 0.80 1.67e-01 1.00e+00
3NUPR1, PRDX1, ITGB2
 200
HALLMARK_XENOBIOTIC_METABOLISM 4.35e-02 4.05 0.80 1.67e-01 1.00e+00
3CYP27A1, APOE, BLVRB
 200
HALLMARK_HEME_METABOLISM 4.35e-02 4.05 0.80 1.67e-01 1.00e+00
3ACP5, CTSB, BLVRB
 200
HALLMARK_APOPTOSIS 1.32e-01 3.28 0.38 4.46e-01 1.00e+00
2LGALS3, IL18
 161
HALLMARK_ADIPOGENESIS 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2PLIN2, APOE
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.85e-01 2.63 0.31 5.44e-01 1.00e+00
2FABP5, BLVRB
 200
HALLMARK_ANGIOGENESIS 1.34e-01 7.29 0.18 4.46e-01 1.00e+00
1SPP1
 36
HALLMARK_PROTEIN_SECRETION 3.17e-01 2.68 0.07 8.82e-01 1.00e+00
1CD63
 96
HALLMARK_PEROXISOME 3.39e-01 2.48 0.06 8.91e-01 1.00e+00
1PRDX1
 104
HALLMARK_BILE_ACID_METABOLISM 3.59e-01 2.30 0.06 8.98e-01 1.00e+00
1CYP27A1
 112

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_LYSOSOME 6.46e-21 55.87 27.93 1.20e-18 1.20e-18
16CTSD, CD68, ACP5, CTSZ, CTSB, FUCA1, PSAP, LIPA, CTSL, GM2A, NPC2, CD63, CTSH, CTSA, ASAH1, CTSS
 121
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 7.12e-03 17.34 1.95 4.41e-01 1.00e+00
2IL4I1, GLUL
 32
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 5.05e-03 9.38 1.83 4.41e-01 9.39e-01
3CTSB, CTSL, CTSS
 88
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 1.15e-02 13.35 1.52 5.34e-01 1.00e+00
2FTH1, BLVRB
 41
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.67e-02 5.95 1.17 6.21e-01 1.00e+00
3FCER1G, ITGB2, TYROBP
 137
KEGG_PPAR_SIGNALING_PATHWAY 3.05e-02 7.77 0.90 9.45e-01 1.00e+00
2CYP27A1, FABP5
 69
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 7.67e-02 4.57 0.53 1.00e+00 1.00e+00
2MMP9, ITGB2
 116
KEGG_OTHER_GLYCAN_DEGRADATION 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1FUCA1
 16
KEGG_RIBOFLAVIN_METABOLISM 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1ACP5
 16
KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS 6.18e-02 16.98 0.40 1.00e+00 1.00e+00
1CYP27A1
 16
KEGG_RENIN_ANGIOTENSIN_SYSTEM 6.56e-02 15.93 0.37 1.00e+00 1.00e+00
1CTSA
 17
KEGG_STEROID_BIOSYNTHESIS 6.56e-02 15.93 0.37 1.00e+00 1.00e+00
1LIPA
 17
KEGG_PHENYLALANINE_METABOLISM 6.93e-02 14.99 0.35 1.00e+00 1.00e+00
1IL4I1
 18
KEGG_NITROGEN_METABOLISM 8.77e-02 11.59 0.28 1.00e+00 1.00e+00
1GLUL
 23
KEGG_ASTHMA 1.13e-01 8.79 0.21 1.00e+00 1.00e+00
1FCER1G
 30
KEGG_ETHER_LIPID_METABOLISM 1.23e-01 7.97 0.19 1.00e+00 1.00e+00
1PLA2G7
 33
KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 1.27e-01 7.73 0.19 1.00e+00 1.00e+00
1IL4I1
 34
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 1.41e-01 6.89 0.17 1.00e+00 1.00e+00
1VAMP8
 38
KEGG_SPHINGOLIPID_METABOLISM 1.44e-01 6.71 0.16 1.00e+00 1.00e+00
1ASAH1
 39
KEGG_TRYPTOPHAN_METABOLISM 1.47e-01 6.54 0.16 1.00e+00 1.00e+00
1IL4I1
 40

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr5q33 6.89e-02 4.87 0.57 1.00e+00 1.00e+00
2ATOX1, GM2A
 109
chr20q13 2.00e-01 2.01 0.40 1.00e+00 1.00e+00
3CTSZ, MMP9, CTSA
 400
chr1q25 1.31e-01 3.30 0.38 1.00e+00 1.00e+00
2NPL, GLUL
 160
chr19q13 6.12e-01 1.20 0.37 1.00e+00 1.00e+00
5APOC1, APOE, IL4I1, BLVRB, TYROBP
 1165
chr2p11 1.92e-01 2.57 0.30 1.00e+00 1.00e+00
2CAPG, VAMP8
 205
chr1q23 2.09e-01 2.42 0.28 1.00e+00 1.00e+00
2FCER1G, CD84
 217
chr21q22 3.99e-01 1.48 0.17 1.00e+00 1.00e+00
2CSTB, ITGB2
 353
chr1q21 6.64e-01 1.34 0.16 1.00e+00 1.00e+00
2S100A11, CTSS
 392
chr8p22 1.64e-01 5.80 0.14 1.00e+00 1.00e+00
1ASAH1
 45
chr4q22 2.43e-01 3.70 0.09 1.00e+00 1.00e+00
1SPP1
 70
chr14q22 3.01e-01 2.87 0.07 1.00e+00 1.00e+00
1LGALS3
 90
chr7p15 3.17e-01 2.68 0.07 1.00e+00 1.00e+00
1GPNMB
 96
chr11q22 3.23e-01 2.63 0.06 1.00e+00 1.00e+00
1MMP12
 98
chr1q24 3.87e-01 2.09 0.05 1.00e+00 1.00e+00
1CREG1
 123
chr2q35 3.94e-01 2.04 0.05 1.00e+00 1.00e+00
1CYP27A1
 126
chr1p35 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1RAB42
 130
chr15q25 4.53e-01 1.69 0.04 1.00e+00 1.00e+00
1CTSH
 152
chr16p12 4.78e-01 1.56 0.04 1.00e+00 1.00e+00
1OTOA
 164
chr7q21 4.78e-01 1.56 0.04 1.00e+00 1.00e+00
1BRI3
 164
chr8q21 5.06e-01 1.44 0.04 1.00e+00 1.00e+00
1FABP5
 178

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
TCANNTGAY_SREBP1_01 2.21e-03 4.31 1.63 1.00e+00 1.00e+00
7GPNMB, CTSD, CYP27A1, PSAP, GRN, CTSA, CTSS
 479
CBFA2T2_TARGET_GENES 1.59e-03 2.90 1.44 1.00e+00 1.00e+00
14GPNMB, CSTB, CTSD, APOC1, ACP5, CTSB, PLIN2, NPL, ATOX1, CTSL, GRN, CD63, CTSH, CTSA
 1694
ZNF354B_TARGET_GENES 8.25e-03 5.43 1.41 1.00e+00 1.00e+00
4CSTB, CTSD, GRN, CTSA
 204
ZNF490_TARGET_GENES 1.11e-02 4.03 1.24 1.00e+00 1.00e+00
5CTSB, S100A11, GRN, LGALS1, VAMP8
 350
NFAT_Q6 1.60e-02 4.44 1.15 1.00e+00 1.00e+00
4CAPG, LGALS1, VAMP8, CD84
 249
PEA3_Q6 1.91e-02 4.20 1.09 1.00e+00 1.00e+00
4FUCA1, IL18, CTSS, CD84
 263
TFEB_TARGET_GENES 2.88e-02 2.27 1.01 1.00e+00 1.00e+00
10CTSD, CD68, ACP5, CTSB, PLIN2, IL4I1, GRN, CD63, CTSA, BRI3
 1387
RYTTCCTG_ETS2_B 6.16e-02 2.16 0.87 1.00e+00 1.00e+00
8MMP9, PSAP, FTH1, FCER1G, CTSA, TYROBP, CTSS, VAMP8
 1112
SMN1_SMN2_TARGET_GENES 8.12e-02 2.22 0.84 1.00e+00 1.00e+00
7CAPG, CTSB, CD63, ITGB2, BLVRB, CTSS, CD84
 922
LXR_Q3 4.08e-02 6.59 0.76 1.00e+00 1.00e+00
2APOC1, BLVRB
 81
SS18_SSX1_FUSION_UNIPROT_Q8IZH1_UNREVIEWED_TARGET_GENES 5.22e-02 5.72 0.66 1.00e+00 1.00e+00
2CD63, GLUL
 93
LXR_DR4_Q3 5.22e-02 5.72 0.66 1.00e+00 1.00e+00
2APOC1, BLVRB
 93
ELF1_Q6 7.32e-02 3.24 0.64 1.00e+00 1.00e+00
3FCER1G, CTSA, TYROBP
 249
GREB1_TARGET_GENES 1.60e-01 1.82 0.63 1.00e+00 1.00e+00
6GPNMB, CTSB, S100A11, CD63, ITGB2, BLVRB
 941
IRF1_Q6 8.29e-02 3.07 0.61 1.00e+00 1.00e+00
3TYROBP, CTSS, VAMP8
 263
DACH1_TARGET_GENES 1.77e-01 1.74 0.60 1.00e+00 1.00e+00
6CTSD, PSAP, CD63, LGALS1, GLUL, ASAH1
 987
FOXE1_TARGET_GENES 1.97e-01 1.92 0.59 1.00e+00 1.00e+00
5CSTB, IL4I1, PRDX1, CTSA, GLUL
 728
ZNF768_TARGET_GENES 3.31e-01 1.52 0.58 1.00e+00 1.00e+00
7APOE, GRN, OTOA, FTH1, TYROBP, ASAH1, CTSS
 1346
RBM34_TARGET_GENES 2.76e-01 1.65 0.57 1.00e+00 1.00e+00
6CSTB, PLIN2, ATOX1, CTSH, CTSA, BRI3
 1038
ZNF282_TARGET_GENES 2.81e-01 1.62 0.56 1.00e+00 1.00e+00
6APOC1, CD68, ACP5, CTSZ, PRDX1, CTSA
 1058

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS 3.90e-07 90.00 20.43 2.65e-04 2.92e-03
4CTSB, CTSL, CTSH, CTSS
 16
GOBP_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY 1.57e-24 28.09 15.39 1.06e-20 1.17e-20
27CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, S100A11, GM2A, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 550
GOBP_ELASTIN_CATABOLIC_PROCESS 1.54e-04 172.68 14.09 4.12e-02 1.00e+00
2CTSL, MMP12
 5
GOBP_MYELOID_LEUKOCYTE_ACTIVATION 6.32e-24 25.25 13.84 1.58e-20 4.73e-20
28CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, S100A11, GM2A, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 659
GOBP_COLLAGEN_CATABOLIC_PROCESS 2.72e-08 41.49 13.69 2.26e-05 2.04e-04
6CTSD, CTSB, MMP9, CTSL, CTSS, MMP12
 47
GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 2.84e-24 24.95 13.67 1.06e-20 2.13e-20
29CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, S100A11, GM2A, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, LGALS1, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 722
GOBP_RESPONSE_TO_THYROID_HORMONE 1.85e-06 57.04 13.59 1.07e-03 1.39e-02
4CTSB, CTSL, CTSH, CTSS
 23
GOBP_LIPID_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER 2.31e-04 129.66 11.45 5.57e-02 1.00e+00
2APOE, FABP5
 6
GOBP_LEUKOCYTE_MEDIATED_IMMUNITY 8.70e-21 18.86 10.35 1.30e-17 6.51e-17
28CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, S100A11, GM2A, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 873
GOBP_GLYCOLIPID_TRANSPORT 3.22e-04 103.49 9.64 6.15e-02 1.00e+00
2PSAP, NPC2
 7
GOBP_EXOCYTOSIS 2.58e-19 17.01 9.35 3.22e-16 1.93e-15
27CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, S100A11, GM2A, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 891
GOBP_CELL_ACTIVATION 4.81e-21 17.03 9.19 8.99e-18 3.60e-17
33GPNMB, CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, APOE, S100A11, CTSL, GM2A, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, PRDX1, LGALS1, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 1461
GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS 9.37e-06 36.12 8.90 4.67e-03 7.01e-02
4CD68, APOE, FCER1G, ITGB2
 34
GOBP_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE_CLEARANCE 4.28e-04 86.37 8.33 7.29e-02 1.00e+00
2APOC1, APOE
 8
GOBP_IMMUNE_EFFECTOR_PROCESS 7.47e-19 14.83 8.12 7.98e-16 5.59e-15
30CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, MMP9, FUCA1, PSAP, S100A11, GM2A, IL18, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, LGALS1, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, MMP12, BRI3, VAMP8, CD84
 1296
GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_ESTERIFICATION 5.49e-04 74.10 7.33 8.39e-02 1.00e+00
2APOC1, APOE
 9
GOBP_ELASTIN_METABOLIC_PROCESS 5.49e-04 74.10 7.33 8.39e-02 1.00e+00
2CTSL, MMP12
 9
GOBP_NEUROINFLAMMATORY_RESPONSE 2.66e-05 27.14 6.78 1.17e-02 1.99e-01
4MMP9, NUPR1, IL18, GRN
 44
GOBP_SECRETION 2.08e-16 12.05 6.62 1.95e-13 1.56e-12
29CSTB, CTSD, CD68, CTSZ, CTSB, LGALS3, SPP1, MMP9, FUCA1, PSAP, APOE, S100A11, GM2A, NPC2, GRN, FTH1, FABP5, FCER1G, CD63, CTSH, CTSA, ITGB2, CREG1, TYROBP, ASAH1, CTSS, BRI3, VAMP8, CD84
 1464
GOBP_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE 6.85e-04 64.86 6.55 9.32e-02 1.00e+00
2APOC1, APOE
 10

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_DN 1.61e-25 51.06 27.16 7.83e-22 7.83e-22
21CD68, ACP5, CTSZ, CTSB, PLA2G7, LGALS3, MMP9, PSAP, NPL, LIPA, CTSL, GM2A, IL18, FTH1, CD63, CTSH, CREG1, TYROBP, ASAH1, CTSS, MMP12
 198
GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_DN 4.34e-22 42.31 22.14 1.06e-18 2.12e-18
19CAPG, APOC1, CYP27A1, CTSZ, CTSB, SPP1, FUCA1, PSAP, LIPA, CTSL, NPC2, GRN, CD63, CTSA, GLUL, ITGB2, CREG1, BLVRB, TYROBP
 200
GSE24634_TEFF_VS_TCONV_DAY10_IN_CULTURE_DN 1.78e-20 38.62 20.01 2.16e-17 8.66e-17
18GPNMB, CAPG, CTSZ, LGALS3, SPP1, NUPR1, PSAP, NPL, LIPA, NPC2, GRN, FCER1G, CD63, CTSH, GLUL, ITGB2, CREG1, BLVRB
 200
GSE29618_MONOCYTE_VS_MDC_DAY7_FLU_VACCINE_UP 1.78e-20 38.62 20.01 2.16e-17 8.66e-17
18CTSD, CD68, CYP27A1, CTSB, PLA2G7, LGALS3, FUCA1, PSAP, PLIN2, NPL, CTSL, NPC2, CD63, CTSA, GLUL, CREG1, ASAH1, CTSS
 200
GSE29618_MONOCYTE_VS_MDC_UP 2.27e-17 31.95 16.17 2.21e-14 1.10e-13
16CTSD, CD68, CYP27A1, CTSB, PLA2G7, PSAP, NPL, CTSL, NPC2, FCER1G, CD63, GLUL, CREG1, TYROBP, ASAH1, CTSS
 200
GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN 7.03e-16 28.93 14.43 4.89e-13 3.43e-12
15CAPG, CTSB, LGALS3, PSAP, NPL, S100A11, NPC2, GRN, FCER1G, CTSH, GLUL, CREG1, TYROBP, ASAH1, CTSS
 200
GSE7509_DC_VS_MONOCYTE_UP 7.03e-16 28.93 14.43 4.89e-13 3.43e-12
15CTSD, CD68, CTSB, LGALS3, SPP1, PSAP, PLIN2, APOE, GM2A, FABP5, CD63, CTSH, LGALS1, CREG1, MMP12
 200
GSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_UP 1.61e-14 26.55 13.00 8.76e-12 7.83e-11
14CAPG, CTSD, CYP27A1, CTSZ, LGALS3, PSAP, CTSL, GM2A, GRN, GLUL, CREG1, TYROBP, ASAH1, BRI3
 197
GSE24634_TREG_VS_TCONV_POST_DAY5_IL4_CONVERSION_DN 1.72e-14 26.41 12.93 8.76e-12 8.39e-11
14CD68, ACP5, CTSZ, CTSB, LGALS3, LIPA, NPC2, GRN, FCER1G, CTSA, CREG1, TYROBP, CTSS, CD84
 198
GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_DN 1.98e-14 26.13 12.79 8.76e-12 9.64e-11
14CAPG, CTSB, LGALS3, PSAP, S100A11, NPC2, GRN, FCER1G, CTSH, CTSA, GLUL, CREG1, ASAH1, CTSS
 200
GSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_DN 1.98e-14 26.13 12.79 8.76e-12 9.64e-11
14ACP5, CTSB, PLA2G7, SPP1, PSAP, ATOX1, LIPA, CTSL, GM2A, NPC2, CD63, TYROBP, CTSS, CD84
 200
GSE34156_UNTREATED_VS_6H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_UP 4.15e-13 23.85 11.44 1.44e-10 2.02e-09
13CYP27A1, CTSZ, LGALS3, PSAP, GM2A, NPC2, GRN, CD63, LGALS1, GLUL, CREG1, ASAH1, BRI3
 197
GSE34156_NOD2_LIGAND_VS_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_DN 4.15e-13 23.85 11.44 1.44e-10 2.02e-09
13CAPG, CTSD, CTSZ, LGALS3, CTSL, GM2A, GRN, GLUL, CREG1, BLVRB, TYROBP, ASAH1, BRI3
 197
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 5.03e-13 23.47 11.26 1.44e-10 2.45e-09
13CTSD, CTSB, LGALS3, PSAP, NPL, GM2A, GRN, FCER1G, CTSA, CREG1, BLVRB, TYROBP, ASAH1
 200
GSE22886_NAIVE_BCELL_VS_MONOCYTE_DN 5.03e-13 23.47 11.26 1.44e-10 2.45e-09
13CAPG, CTSD, CTSB, LGALS3, PSAP, NPL, S100A11, GRN, FCER1G, LGALS1, CREG1, TYROBP, ASAH1
 200
GSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_DN 5.03e-13 23.47 11.26 1.44e-10 2.45e-09
13ACP5, CTSZ, CTSB, PLA2G7, LGALS3, PSAP, NPL, ATOX1, IL18, LGALS1, ITGB2, CREG1, ASAH1
 200
GSE29618_BCELL_VS_MONOCYTE_DN 5.03e-13 23.47 11.26 1.44e-10 2.45e-09
13CD68, CTSB, PSAP, NPL, S100A11, CTSL, CD63, CTSA, ITGB2, CREG1, BLVRB, CTSS, VAMP8
 200
GSE6269_FLU_VS_STAPH_AUREUS_INF_PBMC_DN 3.45e-11 22.58 10.24 8.02e-09 1.68e-07
11CTSD, CTSB, LGALS3, NPL, NPC2, GRN, FTH1, CD63, GLUL, CREG1, BLVRB
 167
GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12CTSD, CTSB, LGALS3, PSAP, NPL, S100A11, FCER1G, CTSA, GLUL, CREG1, BLVRB, TYROBP
 200
GSE22886_NAIVE_TCELL_VS_MONOCYTE_DN 1.15e-11 20.99 9.83 2.80e-09 5.60e-08
12CAPG, CTSB, LGALS3, PSAP, NPL, S100A11, NPC2, GRN, CTSH, GLUL, CREG1, ASAH1
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
ITGB2 41 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
CREG1 42 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Regulates transcription in tethering assays (PMID: 9710587). Unlikely to be a TF, based on the lack of a canonical DBD
HMOX1 52 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Well characterized enzyme with no additional domains. Included only because GO lists it as a regulator of TFs. No support for DNA binding activity.
CD36 55 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NR1H3 59 Yes Inferred motif Obligate heteromer In vivo/Misc source None Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA
SPI1 61 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CEBPA 63 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
MITF 81 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None Binds DNA both as homo- and heterodimers (PMID: 23207919). The structure 4ATI is a homodimer with DNA GTTAGCACATGACCCT.
LGALS9 85 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PLEK 126 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs
SGK1 128 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ANXA4 136 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ATF5 166 Yes Known motif Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Transfac motifs dont correspond to canonical bZIP binding sites. Annotated as obligate heteromer based on peptide array studies (PMID:12805554).
HAVCR2 191 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ENO1 220 No Unlikely to be sequence specific TF Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain Enolase - DNA binding not shown to be direct
SYK 228 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Known co-factor
HCK 233 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits TP73-mediated transcription activation (PMID: 17535448)
PYCARD 243 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
CMKLR1 258 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a G protein-coupled receptor for the chemoattractant adipokine chemerin
TLR4 290 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T230_AGTGCCGAGAAGTCTA-1 Macrophage:monocyte-derived:IFNa 0.19 2139.53
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.43, DC:monocyte-derived:LPS: 0.43, DC:monocyte-derived:Galectin-1: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, DC:monocyte-derived: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IFNa: 0.42, DC:monocyte-derived:AEC-conditioned: 0.42, Macrophage:monocyte-derived:S._aureus: 0.42
T230_TACACCCTCCACGGGT-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.21 1125.42
Raw ScoresMacrophage:monocyte-derived:IL-4/Dex/TGFb: 0.46, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.46, Macrophage:monocyte-derived:M-CSF: 0.45, Macrophage:monocyte-derived:IL-4/cntrl: 0.45, Macrophage:monocyte-derived:IL-4/TGFb: 0.45, Macrophage:Alveolar: 0.45, Macrophage:monocyte-derived:IFNa: 0.45, Macrophage:Alveolar:B._anthacis_spores: 0.45, DC:monocyte-derived: 0.45, DC:monocyte-derived:LPS: 0.45
T200_GGAATGGTCCGTGTAA-1 Macrophage:monocyte-derived:IFNa 0.19 969.39
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.47, DC:monocyte-derived:AEC-conditioned: 0.46, Macrophage:monocyte-derived:IFNa: 0.46, Monocyte:anti-FcgRIIB: 0.46, Macrophage:monocyte-derived:S._aureus: 0.46, Macrophage:Alveolar: 0.46, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.46, DC:monocyte-derived:LPS: 0.46, Macrophage:monocyte-derived: 0.46
T162_TGACGCGCAGACATCT-1 Macrophage:monocyte-derived:S._aureus 0.13 846.43
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.38, Macrophage:monocyte-derived: 0.38, Macrophage:Alveolar: 0.38, Macrophage:monocyte-derived:M-CSF: 0.37, DC:monocyte-derived: 0.37, Monocyte:anti-FcgRIIB: 0.37, Macrophage:Alveolar:B._anthacis_spores: 0.37, DC:monocyte-derived:antiCD40/VAF347: 0.37, DC:monocyte-derived:Schuler_treatment: 0.37, DC:monocyte-derived:immature: 0.37
T230_CGTTAGATCGCCAGTG-1 Macrophage:monocyte-derived:M-CSF 0.18 816.96
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived: 0.43, Macrophage:monocyte-derived:IFNa: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, DC:monocyte-derived:immature: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.41, DC:monocyte-derived:Galectin-1: 0.41
T162_CCACTTGTCGCCGAAC-1 Macrophage:monocyte-derived:IFNa 0.13 744.15
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, Macrophage:monocyte-derived: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, DC:monocyte-derived:Galectin-1: 0.4, Monocyte:anti-FcgRIIB: 0.4, DC:monocyte-derived:LPS: 0.39, DC:monocyte-derived: 0.39, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.39, DC:monocyte-derived:antiCD40/VAF347: 0.39
T162_GGTAATCCAATAGTAG-1 Macrophage:Alveolar 0.19 726.66
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.46, Macrophage:monocyte-derived:M-CSF: 0.46, Macrophage:Alveolar: 0.46, DC:monocyte-derived:LPS: 0.45, Macrophage:monocyte-derived:S._aureus: 0.45, DC:monocyte-derived:Galectin-1: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45, Macrophage:monocyte-derived:IFNa: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45
T162_GGGCTACAGACAAGCC-1 Macrophage:monocyte-derived:IFNa 0.16 654.92
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.44, Macrophage:Alveolar:B._anthacis_spores: 0.43, Macrophage:monocyte-derived:IFNa: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, Monocyte:anti-FcgRIIB: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:Alveolar: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, DC:monocyte-derived:LPS: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42
T162_GTAACACGTACTTCCC-1 Monocyte:anti-FcgRIIB 0.10 627.92
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.35, DC:monocyte-derived:Galectin-1: 0.35, Monocyte:anti-FcgRIIB: 0.35, Macrophage:Alveolar: 0.35, DC:monocyte-derived:antiCD40/VAF347: 0.35, DC:monocyte-derived:LPS: 0.35, Macrophage:Alveolar:B._anthacis_spores: 0.35, Macrophage:monocyte-derived: 0.35, DC:monocyte-derived: 0.35, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.35
T162_TTGGGTACACACAGAG-1 Macrophage:monocyte-derived:IL-4/Dex/TGFb 0.17 627.06
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.44, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.44, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, Monocyte:leukotriene_D4: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, DC:monocyte-derived: 0.42, Monocyte:anti-FcgRIIB: 0.42, DC:monocyte-derived:immature: 0.42
T162_AGAGCCCAGCTCGCAC-1 Macrophage:Alveolar 0.16 623.11
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg: 0.45, Macrophage:Alveolar: 0.44, Macrophage:Alveolar:B._anthacis_spores: 0.44, Monocyte:anti-FcgRIIB: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Macrophage:monocyte-derived:IFNa: 0.44, DC:monocyte-derived:LPS: 0.44
T162_TACTGCCCATATCGGT-1 Macrophage:monocyte-derived:S._aureus 0.10 618.52
Raw ScoresMacrophage:monocyte-derived: 0.37, Monocyte:MCSF: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, Macrophage:monocyte-derived:IL-4/cntrl: 0.37, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.36, Monocyte:CXCL4: 0.36, Macrophage:monocyte-derived:IL-4/TGFb: 0.36, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.36, Macrophage:monocyte-derived:M-CSF: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36
T162_TACAGGTGTACCTGTA-1 DC:monocyte-derived:antiCD40/VAF347 0.15 613.08
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Macrophage:Alveolar: 0.43, DC:monocyte-derived: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Macrophage:monocyte-derived: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.43, DC:monocyte-derived:Galectin-1: 0.43, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.43
T200_ATCACAGCAGCACAGA-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.22 605.22
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.49, Macrophage:monocyte-derived:M-CSF: 0.49, DC:monocyte-derived:LPS: 0.49, DC:monocyte-derived:AEC-conditioned: 0.48, Macrophage:monocyte-derived:S._aureus: 0.48, DC:monocyte-derived:Galectin-1: 0.48, Monocyte:leukotriene_D4: 0.48, Macrophage:monocyte-derived:IFNa: 0.48, Macrophage:Alveolar:B._anthacis_spores: 0.48
T162_CTACGGGAGAGTTGAT-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.09 600.13
Raw ScoresMacrophage:monocyte-derived: 0.36, Macrophage:monocyte-derived:IFNa: 0.36, DC:monocyte-derived:Schuler_treatment: 0.36, Macrophage:monocyte-derived:S._aureus: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, DC:monocyte-derived:antiCD40/VAF347: 0.36, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.36, DC:monocyte-derived:CD40L: 0.36, DC:monocyte-derived:anti-DC-SIGN_2h: 0.35, Macrophage:monocyte-derived:M-CSF: 0.35
T162_ACTACGACATCGAAGG-1 Macrophage:Alveolar:B._anthacis_spores 0.16 597.89
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.43, Macrophage:monocyte-derived:S._aureus: 0.43, Macrophage:Alveolar: 0.42, Monocyte:anti-FcgRIIB: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42, Macrophage:monocyte-derived: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IFNa: 0.42, DC:monocyte-derived: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41
T162_AGATGCTTCCCTCTAG-1 Macrophage:Alveolar:B._anthacis_spores 0.17 596.17
Raw ScoresMacrophage:Alveolar: 0.44, Macrophage:Alveolar:B._anthacis_spores: 0.44, Macrophage:monocyte-derived: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44, Monocyte:anti-FcgRIIB: 0.44, Macrophage:monocyte-derived:IL-4/cntrl: 0.44, Macrophage:monocyte-derived:IFNa: 0.44, Macrophage:monocyte-derived:IL-4/TGFb: 0.43, Monocyte:MCSF: 0.43
T162_CTCTGGTTCCAAATGC-1 Macrophage:monocyte-derived:M-CSF 0.17 568.59
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Macrophage:monocyte-derived:M-CSF: 0.43, Monocyte:anti-FcgRIIB: 0.43, Macrophage:Alveolar:B._anthacis_spores: 0.43, DC:monocyte-derived:Galectin-1: 0.43, DC:monocyte-derived:LPS: 0.43, Macrophage:Alveolar: 0.43, Macrophage:monocyte-derived: 0.43, DC:monocyte-derived: 0.43
T200_TAGAGTCCAGAGAGGG-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.22 559.03
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Monocyte:anti-FcgRIIB: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, DC:monocyte-derived:LPS: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:IFNa: 0.44, Macrophage:Alveolar:B._anthacis_spores: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44
T162_GGAATCTGTGAACTAA-1 DC:monocyte-derived:antiCD40/VAF347 0.17 558.58
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43, Macrophage:monocyte-derived: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.43, Macrophage:Alveolar:B._anthacis_spores: 0.43, Macrophage:monocyte-derived:IFNa: 0.42, Macrophage:monocyte-derived:M-CSF: 0.42, DC:monocyte-derived: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42, DC:monocyte-derived:AEC-conditioned: 0.42
T162_TCTATCACAGCTCATA-1 DC:monocyte-derived:antiCD40/VAF347 0.13 557.56
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.41, Monocyte:anti-FcgRIIB: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, Macrophage:Alveolar: 0.4, Macrophage:monocyte-derived:IFNa: 0.4, DC:monocyte-derived: 0.4, DC:monocyte-derived:LPS: 0.4, DC:monocyte-derived:antiCD40/VAF347: 0.4, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.4
T200_TCACTCGCACTACCGG-1 Monocyte:CD14+ 0.18 543.90
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.44, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, Monocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Monocyte:anti-FcgRIIB: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, Monocyte: 0.43, DC:monocyte-derived:anti-DC-SIGN_2h: 0.43
T162_GAGAGGTCAACAGCCC-1 Macrophage:Alveolar 0.15 526.81
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Macrophage:Alveolar: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Macrophage:Alveolar:B._anthacis_spores: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.41, DC:monocyte-derived:AEC-conditioned: 0.41, Macrophage:monocyte-derived:IL-4/TGFb: 0.41, Macrophage:monocyte-derived:IL-4/cntrl: 0.41
T162_TCATGTTCAACACAAA-1 DC:monocyte-derived:antiCD40/VAF347 0.12 521.51
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.42, Macrophage:monocyte-derived:IFNa: 0.42, Macrophage:monocyte-derived:S._aureus: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42, Macrophage:monocyte-derived: 0.42, DC:monocyte-derived:Galectin-1: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.42, DC:monocyte-derived:LPS: 0.42, DC:monocyte-derived: 0.42
T162_AACCAACAGAGCTGCA-1 Macrophage:Alveolar:B._anthacis_spores 0.16 516.33
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.41, DC:monocyte-derived:antiCD40/VAF347: 0.41, Macrophage:Alveolar:B._anthacis_spores: 0.41, Macrophage:monocyte-derived:IFNa: 0.4, Macrophage:Alveolar: 0.4, Macrophage:monocyte-derived: 0.4, Monocyte:anti-FcgRIIB: 0.4, DC:monocyte-derived:Galectin-1: 0.4, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4
T162_TCTTTGAGTAACTTCG-1 Macrophage:monocyte-derived:S._aureus 0.09 513.84
Raw ScoresMacrophage:monocyte-derived: 0.36, Macrophage:monocyte-derived:IFNa: 0.36, Macrophage:monocyte-derived:S._aureus: 0.36, DC:monocyte-derived:anti-DC-SIGN_2h: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.36, Macrophage:monocyte-derived:M-CSF: 0.35, Macrophage:Alveolar:B._anthacis_spores: 0.35, DC:monocyte-derived:immature: 0.35, Macrophage:Alveolar: 0.35
T162_CAGATACAGGCACTCC-1 Monocyte:anti-FcgRIIB 0.16 510.45
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.43, Monocyte:anti-FcgRIIB: 0.43, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.43, Macrophage:Alveolar: 0.43, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.43, Macrophage:monocyte-derived: 0.43, Macrophage:monocyte-derived:IL-4/TGFb: 0.43, Macrophage:monocyte-derived:IL-4/cntrl: 0.43, Macrophage:Alveolar:B._anthacis_spores: 0.43, DC:monocyte-derived:Galectin-1: 0.43
T162_ACCTACCCAACTTGCA-1 DC:monocyte-derived:antiCD40/VAF347 0.13 506.25
Raw ScoresDC:monocyte-derived:antiCD40/VAF347: 0.37, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, DC:monocyte-derived:Galectin-1: 0.37, DC:monocyte-derived:Schuler_treatment: 0.37, DC:monocyte-derived: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.36, DC:monocyte-derived:LPS: 0.36, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.36, DC:monocyte-derived:anti-DC-SIGN_2h: 0.36
T162_GAGGGATTCTATCGGA-1 Macrophage:Alveolar:B._anthacis_spores 0.16 503.02
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:S._aureus: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, Macrophage:Alveolar: 0.42, Monocyte:anti-FcgRIIB: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, DC:monocyte-derived:AEC-conditioned: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42
T162_GGGTGTCTCGACACTA-1 Macrophage:monocyte-derived:IFNa 0.10 500.52
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.38, Macrophage:Alveolar:B._anthacis_spores: 0.38, Macrophage:monocyte-derived: 0.38, Macrophage:monocyte-derived:IFNa: 0.37, Macrophage:Alveolar: 0.37, Macrophage:monocyte-derived:S._aureus: 0.37, Monocyte:anti-FcgRIIB: 0.37, DC:monocyte-derived: 0.37, DC:monocyte-derived:antiCD40/VAF347: 0.37, Macrophage:monocyte-derived:M-CSF: 0.37
T162_CCACAAACATAACTCG-1 Macrophage:monocyte-derived:S._aureus 0.13 499.59
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.39, Macrophage:monocyte-derived: 0.39, DC:monocyte-derived:Schuler_treatment: 0.38, DC:monocyte-derived:CD40L: 0.38, DC:monocyte-derived:antiCD40/VAF347: 0.38, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.38, Macrophage:monocyte-derived:IFNa: 0.38, Macrophage:Alveolar:B._anthacis_spores: 0.38, DC:monocyte-derived: 0.38, Monocyte:anti-FcgRIIB: 0.38
T162_CATGGATCAAGTCATC-1 Macrophage:monocyte-derived 0.11 499.30
Raw ScoresMacrophage:monocyte-derived: 0.38, Macrophage:monocyte-derived:S._aureus: 0.38, Monocyte:MCSF: 0.37, Macrophage:monocyte-derived:IFNa: 0.37, Macrophage:monocyte-derived:IL-4/cntrl: 0.37, Macrophage:monocyte-derived:IL-4/TGFb: 0.37, Macrophage:Alveolar: 0.37, Monocyte:CXCL4: 0.37, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.36, Macrophage:Alveolar:B._anthacis_spores: 0.36
T27_ATTGGTGGTGCTAGCC.1 DC:monocyte-derived:antiCD40/VAF347 0.16 497.63
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.42, Monocyte:anti-FcgRIIB: 0.42, Macrophage:monocyte-derived: 0.42, Macrophage:Alveolar:B._anthacis_spores: 0.42, Macrophage:Alveolar: 0.41, DC:monocyte-derived:antiCD40/VAF347: 0.41, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.41, Macrophage:monocyte-derived:IFNa: 0.41, DC:monocyte-derived:Schuler_treatment: 0.41, Macrophage:monocyte-derived:IL-4/cntrl: 0.41
T162_CTCAAGACACGGATCC-1 Macrophage:monocyte-derived:S._aureus 0.13 497.31
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.37, Macrophage:monocyte-derived:IFNa: 0.37, Macrophage:monocyte-derived: 0.37, Macrophage:Alveolar:B._anthacis_spores: 0.36, Macrophage:Alveolar: 0.36, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.36, DC:monocyte-derived:Galectin-1: 0.36, DC:monocyte-derived: 0.36, DC:monocyte-derived:AEC-conditioned: 0.36, DC:monocyte-derived:antiCD40/VAF347: 0.36
T162_ACACGCGCATTCTCTA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.14 492.89
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:S._aureus: 0.39, Macrophage:Alveolar:B._anthacis_spores: 0.39, DC:monocyte-derived:Poly(IC): 0.39, Monocyte:anti-FcgRIIB: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Macrophage:monocyte-derived:M-CSF: 0.39, DC:monocyte-derived:AEC-conditioned: 0.39, Macrophage:Alveolar: 0.39
T230_GTGCTGGAGCCAGTAG-1 Macrophage:monocyte-derived:M-CSF 0.20 492.00
Raw ScoresDC:monocyte-derived:anti-DC-SIGN_2h: 0.44, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, DC:monocyte-derived: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, DC:monocyte-derived:Galectin-1: 0.42, DC:monocyte-derived:AEC-conditioned: 0.41, Macrophage:Alveolar:B._anthacis_spores: 0.41
T162_ATCGTGACAGTCGCAC-1 Macrophage:monocyte-derived 0.15 489.14
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:IFNa: 0.42, Macrophage:monocyte-derived: 0.42, DC:monocyte-derived:Galectin-1: 0.42, Monocyte:anti-FcgRIIB: 0.42, Macrophage:monocyte-derived:M-CSF: 0.42, Macrophage:Alveolar:B._anthacis_spores: 0.42, Macrophage:monocyte-derived:S._aureus: 0.42, Macrophage:Alveolar: 0.42, DC:monocyte-derived:LPS: 0.42
T200_GAAGGACAGGTATTGA-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.22 483.14
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.47, Macrophage:monocyte-derived:M-CSF: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, DC:monocyte-derived:LPS: 0.45, Monocyte:leukotriene_D4: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, DC:monocyte-derived:Galectin-1: 0.45, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.45, Macrophage:monocyte-derived:IFNa: 0.45, Monocyte:anti-FcgRIIB: 0.44
T162_CAATCGACAAGTCATC-1 Macrophage:Alveolar 0.10 473.90
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.33, Macrophage:Alveolar: 0.33, Macrophage:Alveolar:B._anthacis_spores: 0.33, Macrophage:monocyte-derived: 0.32, Macrophage:monocyte-derived:IFNa: 0.32, Macrophage:monocyte-derived:M-CSF: 0.32, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.32, Macrophage:monocyte-derived:S._aureus: 0.32, Macrophage:monocyte-derived:M-CSF/IFNg: 0.32, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.32
T162_ACAGAAACATCCTAAG-1 Macrophage:monocyte-derived:IFNa 0.14 470.20
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.41, Macrophage:Alveolar: 0.41, Macrophage:monocyte-derived:M-CSF: 0.4, Monocyte:anti-FcgRIIB: 0.4, Macrophage:monocyte-derived: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, Macrophage:monocyte-derived:IFNa: 0.4, DC:monocyte-derived:AEC-conditioned: 0.4, Monocyte:leukotriene_D4: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.39
T162_CTTCTCTTCCACTGGG-1 Macrophage:monocyte-derived:S._aureus 0.11 469.33
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.38, Macrophage:monocyte-derived: 0.37, Macrophage:Alveolar:B._anthacis_spores: 0.37, DC:monocyte-derived:LPS: 0.37, DC:monocyte-derived:antiCD40/VAF347: 0.37, DC:monocyte-derived:Galectin-1: 0.37, DC:monocyte-derived:AEC-conditioned: 0.37, DC:monocyte-derived: 0.37, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.37, Macrophage:monocyte-derived:IFNa: 0.37
T162_GGCACGTTCCGAGCTG-1 Macrophage:monocyte-derived:IFNa 0.14 465.94
Raw ScoresMacrophage:monocyte-derived:IFNa: 0.44, Macrophage:monocyte-derived: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, DC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, Macrophage:Alveolar:B._anthacis_spores: 0.42, Macrophage:monocyte-derived:S._aureus: 0.42, Macrophage:Alveolar: 0.42, DC:monocyte-derived:anti-DC-SIGN_2h: 0.42, DC:monocyte-derived:Galectin-1: 0.42
T200_GGGAGATGTCTCGACG-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.22 463.01
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:leukotriene_D4: 0.46, Monocyte:CD16-: 0.46, Monocyte:anti-FcgRIIB: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Macrophage:monocyte-derived:IFNa: 0.46, DC:monocyte-derived:LPS: 0.46, Monocyte:CD14+: 0.46, Macrophage:monocyte-derived:S._aureus: 0.46
T162_AGAGCAGGTAGCTCGC-1 DC:monocyte-derived:antiCD40/VAF347 0.13 460.28
Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, Monocyte:anti-FcgRIIB: 0.42, Monocyte:leukotriene_D4: 0.42, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.42, DC:monocyte-derived:Galectin-1: 0.42, Macrophage:monocyte-derived:S._aureus: 0.42, DC:monocyte-derived: 0.42, DC:monocyte-derived:LPS: 0.42
T162_TCCGAAATCCTCAGAA-1 Macrophage:monocyte-derived 0.10 457.84
Raw ScoresMacrophage:monocyte-derived: 0.39, Macrophage:monocyte-derived:S._aureus: 0.38, Macrophage:monocyte-derived:IFNa: 0.38, DC:monocyte-derived:immature: 0.38, DC:monocyte-derived:Schuler_treatment: 0.38, Monocyte:MCSF: 0.38, Macrophage:monocyte-derived:IL-4/cntrl: 0.38, Monocyte:anti-FcgRIIB: 0.37, Macrophage:monocyte-derived:IL-4/TGFb: 0.37, DC:monocyte-derived:antiCD40/VAF347: 0.37
T162_AGGGTCCTCGGCTGTG-1 Macrophage:Alveolar:B._anthacis_spores 0.12 454.99
Raw ScoresMacrophage:Alveolar:B._anthacis_spores: 0.39, Macrophage:Alveolar: 0.38, Macrophage:monocyte-derived:S._aureus: 0.38, DC:monocyte-derived:antiCD40/VAF347: 0.38, Macrophage:monocyte-derived:IFNa: 0.38, DC:monocyte-derived:anti-DC-SIGN_2h: 0.38, DC:monocyte-derived:Galectin-1: 0.38, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.38, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.38, Macrophage:monocyte-derived: 0.38
T162_CTATCTACACCAGCCA-1 Macrophage:monocyte-derived 0.12 452.25
Raw ScoresMacrophage:monocyte-derived: 0.43, DC:monocyte-derived:AEC-conditioned: 0.42, Macrophage:monocyte-derived:IFNa: 0.42, Macrophage:monocyte-derived:S._aureus: 0.41, Macrophage:monocyte-derived:M-CSF: 0.41, Monocyte:anti-FcgRIIB: 0.41, Monocyte:leukotriene_D4: 0.41, Monocyte:MCSF: 0.41, DC:monocyte-derived:anti-DC-SIGN_2h: 0.4, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.4
T162_CTCTGGTGTAGCCCTG-1 Macrophage:Alveolar:B._anthacis_spores 0.11 452.24
Raw ScoresMacrophage:monocyte-derived: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, Monocyte:MCSF: 0.39, Macrophage:monocyte-derived:IFNa: 0.39, Macrophage:monocyte-derived:IL-4/cntrl: 0.39, Macrophage:monocyte-derived:IL-4/TGFb: 0.39, Macrophage:Alveolar: 0.39, DC:monocyte-derived:AEC-conditioned: 0.39, Monocyte:CXCL4: 0.39, Macrophage:Alveolar:B._anthacis_spores: 0.39
T162_GTATTGGCAAGACGAC-1 DC:monocyte-derived 0.16 447.22
Raw ScoresMacrophage:monocyte-derived:S._aureus: 0.42, Macrophage:monocyte-derived: 0.42, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.42, DC:monocyte-derived:Galectin-1: 0.42, DC:monocyte-derived: 0.42, Macrophage:monocyte-derived:M-CSF: 0.42, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.42, Macrophage:monocyte-derived:IL-4/cntrl: 0.42, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:IL-4/TGFb: 0.42
T200_ACTTAGGTCTTCCAGC-1 DC:monocyte-derived:AEC-conditioned 0.15 446.04
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.42, Macrophage:monocyte-derived:IFNa: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Macrophage:monocyte-derived:M-CSF: 0.41, Macrophage:monocyte-derived: 0.41, Macrophage:monocyte-derived:IL-4/Dex/cntrl: 0.4, DC:monocyte-derived:LPS: 0.4, Macrophage:monocyte-derived:S._aureus: 0.4, DC:monocyte-derived:Galectin-1: 0.4, Macrophage:Alveolar: 0.4


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.27e-04
Mean rank of genes in gene set: 2798.82
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IL18 0.0037261 27 GTEx DepMap Descartes 2.04 241.73
CD14 0.0023524 62 GTEx DepMap Descartes 9.36 1334.13
CXCL16 0.0018124 112 GTEx DepMap Descartes 1.60 155.38
ITGAX 0.0017507 124 GTEx DepMap Descartes 0.58 26.43
TLR4 0.0010268 290 GTEx DepMap Descartes 0.34 5.62
CCL2 0.0004402 795 GTEx DepMap Descartes 1.89 522.77
CD80 0.0003899 885 GTEx DepMap Descartes 0.12 8.53
IL1B 0.0001617 1624 GTEx DepMap Descartes 7.82 1178.92
IL33 -0.0000149 4257 GTEx DepMap Descartes 0.00 0.39
CCL5 -0.0001396 10233 GTEx DepMap Descartes 0.63 91.53
TNF -0.0003728 12378 GTEx DepMap Descartes 0.81 104.56


M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.63e-03
Mean rank of genes in gene set: 2246.57
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CD14 0.0023524 62 GTEx DepMap Descartes 9.36 1334.13
CD163 0.0009878 318 GTEx DepMap Descartes 1.65 78.66
TGFB1 0.0003097 1053 GTEx DepMap Descartes 0.82 64.63
VEGFA 0.0002631 1202 GTEx DepMap Descartes 0.48 9.79
IL10 0.0002590 1219 GTEx DepMap Descartes 0.57 59.32
IL13 -0.0000277 4970 GTEx DepMap Descartes 0.00 0.00
ARG1 -0.0000617 6902 GTEx DepMap Descartes 0.00 0.00


HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.59e-03
Mean rank of genes in gene set: 429
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
AIF1 0.0014847 177 GTEx DepMap Descartes 9.13 1645.84
CD163 0.0009878 318 GTEx DepMap Descartes 1.65 78.66
RGS10 0.0004416 792 GTEx DepMap Descartes 2.60 556.86




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10054.5
Median rank of genes in gene set: 11107
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HK2 0.0016664 142 GTEx DepMap Descartes 0.28 12.83
UCP2 0.0013371 204 GTEx DepMap Descartes 2.59 265.81
ATP6V1B2 0.0010266 291 GTEx DepMap Descartes 1.12 33.28
LYN 0.0010217 298 GTEx DepMap Descartes 0.89 33.77
DAPK1 0.0003796 903 GTEx DepMap Descartes 0.33 11.56
NFIL3 0.0002980 1092 GTEx DepMap Descartes 0.42 53.86
MYO5A 0.0002875 1116 GTEx DepMap Descartes 0.27 4.86
GLRX 0.0002169 1370 GTEx DepMap Descartes 1.60 96.28
AP1S2 0.0001993 1444 GTEx DepMap Descartes 1.28 77.80
EML4 0.0001975 1453 GTEx DepMap Descartes 0.41 17.30
GNB1 0.0001415 1739 GTEx DepMap Descartes 0.81 55.58
ST3GAL6 0.0001045 2001 GTEx DepMap Descartes 0.25 15.78
SETD7 0.0000825 2205 GTEx DepMap Descartes 0.11 3.92
FAM107B 0.0000613 2453 GTEx DepMap Descartes 0.51 32.00
PDK1 0.0000557 2526 GTEx DepMap Descartes 0.07 1.03
ARL6IP1 0.0000450 2673 GTEx DepMap Descartes 1.37 120.66
DUSP4 0.0000431 2699 GTEx DepMap Descartes 0.26 10.40
INO80C 0.0000253 2979 GTEx DepMap Descartes 0.17 10.59
ANP32A 0.0000174 3146 GTEx DepMap Descartes 0.88 46.47
SEC11C 0.0000167 3159 GTEx DepMap Descartes 0.92 93.44
PPP2R3C 0.0000088 3332 GTEx DepMap Descartes 0.32 38.43
TSPAN13 -0.0000062 3801 GTEx DepMap Descartes 0.29 31.13
LSM3 -0.0000071 3842 GTEx DepMap Descartes 1.28 78.16
PHPT1 -0.0000121 4087 GTEx DepMap Descartes 1.83 289.09
RPS6KA2 -0.0000161 4325 GTEx DepMap Descartes 0.09 2.81
EXOC5 -0.0000261 4864 GTEx DepMap Descartes 0.19 3.54
STRA6 -0.0000269 4911 GTEx DepMap Descartes 0.01 0.60
SLIT1 -0.0000373 5533 GTEx DepMap Descartes 0.04 1.31
SHC3 -0.0000376 5550 GTEx DepMap Descartes 0.01 0.14
GGCT -0.0000392 5626 GTEx DepMap Descartes 0.48 77.64


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.04e-21
Mean rank of genes in gene set: 4665.58
Median rank of genes in gene set: 3626
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CTSB 0.0049809 10 GTEx DepMap Descartes 20.73 1419.88
APOE 0.0039245 21 GTEx DepMap Descartes 117.94 20862.80
LIPA 0.0038137 23 GTEx DepMap Descartes 4.54 408.02
NPC2 0.0037030 28 GTEx DepMap Descartes 10.18 1553.32
GRN 0.0036943 29 GTEx DepMap Descartes 8.99 852.20
CD63 0.0032765 35 GTEx DepMap Descartes 14.41 2690.24
LGALS1 0.0031371 38 GTEx DepMap Descartes 15.51 5512.11
CREG1 0.0029933 42 GTEx DepMap Descartes 3.67 402.33
HEXB 0.0022051 74 GTEx DepMap Descartes 1.31 150.97
LAMP1 0.0021106 82 GTEx DepMap Descartes 1.94 84.53
TSPAN4 0.0020731 87 GTEx DepMap Descartes 1.43 106.68
VIM 0.0020377 90 GTEx DepMap Descartes 15.39 1296.07
HNMT 0.0019766 95 GTEx DepMap Descartes 1.18 84.74
ANXA5 0.0018139 111 GTEx DepMap Descartes 2.77 367.64
GPR137B 0.0017816 120 GTEx DepMap Descartes 0.52 57.10
SDCBP 0.0017696 121 GTEx DepMap Descartes 3.38 202.11
SGK1 0.0017421 128 GTEx DepMap Descartes 3.59 144.25
GNS 0.0017259 133 GTEx DepMap Descartes 1.02 48.86
PPT1 0.0017137 134 GTEx DepMap Descartes 1.75 94.61
CTSC 0.0016730 140 GTEx DepMap Descartes 6.69 200.28
SH3BGRL 0.0015686 159 GTEx DepMap Descartes 2.15 273.79
LITAF 0.0015677 160 GTEx DepMap Descartes 3.10 256.45
FNDC3B 0.0015675 161 GTEx DepMap Descartes 0.51 15.31
ARPC1B 0.0015054 172 GTEx DepMap Descartes 3.66 408.21
ADAM9 0.0014450 186 GTEx DepMap Descartes 0.47 30.11
PCOLCE2 0.0013653 196 GTEx DepMap Descartes 0.22 39.07
RAB31 0.0013635 197 GTEx DepMap Descartes 0.73 45.21
SLC38A6 0.0013560 199 GTEx DepMap Descartes 0.36 28.82
PAPSS2 0.0013369 205 GTEx DepMap Descartes 0.25 14.80
B2M 0.0012926 218 GTEx DepMap Descartes 101.52 8715.55


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.41e-01
Mean rank of genes in gene set: 6876.31
Median rank of genes in gene set: 7156
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOC1 0.0056566 5 GTEx DepMap Descartes 55.54 16862.42
PAPSS2 0.0013369 205 GTEx DepMap Descartes 0.25 14.80
SCARB1 0.0007634 427 GTEx DepMap Descartes 0.23 7.85
NPC1 0.0005971 584 GTEx DepMap Descartes 0.16 6.85
POR 0.0005808 607 GTEx DepMap Descartes 0.51 47.41
FDX1 0.0003337 991 GTEx DepMap Descartes 0.57 37.96
SH3PXD2B 0.0001655 1609 GTEx DepMap Descartes 0.08 2.31
ERN1 0.0001246 1832 GTEx DepMap Descartes 0.28 7.54
SH3BP5 0.0000037 3449 GTEx DepMap Descartes 0.38 23.92
FREM2 -0.0000128 4128 GTEx DepMap Descartes 0.00 0.01
GRAMD1B -0.0000149 4259 GTEx DepMap Descartes 0.05 1.17
SCAP -0.0000301 5102 GTEx DepMap Descartes 0.12 5.28
INHA -0.0000360 5447 GTEx DepMap Descartes 0.00 0.32
FDXR -0.0000404 5686 GTEx DepMap Descartes 0.08 7.07
DHCR7 -0.0000479 6127 GTEx DepMap Descartes 0.07 4.80
BAIAP2L1 -0.0000511 6322 GTEx DepMap Descartes 0.00 0.08
SLC16A9 -0.0000555 6586 GTEx DepMap Descartes 0.03 1.19
SGCZ -0.0000567 6650 GTEx DepMap Descartes 0.00 0.01
FRMD5 -0.0000758 7662 GTEx DepMap Descartes 0.02 0.55
STAR -0.0000922 8488 GTEx DepMap Descartes 0.00 0.26
DHCR24 -0.0000955 8651 GTEx DepMap Descartes 0.03 0.95
PDE10A -0.0001096 9214 GTEx DepMap Descartes 0.03 0.37
HMGCR -0.0001137 9395 GTEx DepMap Descartes 0.10 4.23
JAKMIP2 -0.0001240 9770 GTEx DepMap Descartes 0.10 2.12
DNER -0.0001512 10509 GTEx DepMap Descartes 0.04 2.05
CYB5B -0.0001554 10615 GTEx DepMap Descartes 0.19 8.88
SLC1A2 -0.0001601 10711 GTEx DepMap Descartes 0.04 0.53
IGF1R -0.0001697 10898 GTEx DepMap Descartes 0.07 0.95
LDLR -0.0001716 10946 GTEx DepMap Descartes 0.09 3.03
HMGCS1 -0.0001796 11096 GTEx DepMap Descartes 0.13 4.80


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10899.76
Median rank of genes in gene set: 11814
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SLC44A5 -0.0000462 6035 GTEx DepMap Descartes 0.02 0.89
GREM1 -0.0000551 6560 GTEx DepMap Descartes 0.01 0.16
EPHA6 -0.0000769 7718 GTEx DepMap Descartes 0.01 0.25
RPH3A -0.0000780 7771 GTEx DepMap Descartes 0.02 0.83
ALK -0.0000797 7869 GTEx DepMap Descartes 0.04 1.31
ANKFN1 -0.0000917 8460 GTEx DepMap Descartes 0.00 0.12
FAT3 -0.0000941 8577 GTEx DepMap Descartes 0.02 0.30
EYA1 -0.0001122 9341 GTEx DepMap Descartes 0.03 1.09
RYR2 -0.0001208 9649 GTEx DepMap Descartes 0.02 0.19
HS3ST5 -0.0001266 9865 GTEx DepMap Descartes 0.01 0.68
KCNB2 -0.0001358 10128 GTEx DepMap Descartes 0.01 0.47
EYA4 -0.0001487 10453 GTEx DepMap Descartes 0.02 0.37
CNKSR2 -0.0001529 10550 GTEx DepMap Descartes 0.02 0.47
PTCHD1 -0.0001556 10616 GTEx DepMap Descartes 0.01 0.19
SYNPO2 -0.0001644 10799 GTEx DepMap Descartes 0.08 0.88
SLC6A2 -0.0001647 10802 GTEx DepMap Descartes 0.04 2.43
TMEM132C -0.0001652 10813 GTEx DepMap Descartes 0.01 0.50
PLXNA4 -0.0001748 11006 GTEx DepMap Descartes 0.03 0.30
TMEFF2 -0.0001965 11339 GTEx DepMap Descartes 0.04 2.56
NTRK1 -0.0002007 11394 GTEx DepMap Descartes 0.08 3.78
GAL -0.0002398 11814 GTEx DepMap Descartes 0.31 86.31
RGMB -0.0002428 11838 GTEx DepMap Descartes 0.08 3.14
REEP1 -0.0002455 11861 GTEx DepMap Descartes 0.05 1.92
RBFOX1 -0.0002557 11932 GTEx DepMap Descartes 0.02 0.80
MAB21L2 -0.0002715 12034 GTEx DepMap Descartes 0.15 6.44
IL7 -0.0002853 12111 GTEx DepMap Descartes 0.06 6.10
MAB21L1 -0.0002858 12114 GTEx DepMap Descartes 0.20 12.10
TUBB2A -0.0002943 12143 GTEx DepMap Descartes 0.68 63.94
CNTFR -0.0003071 12201 GTEx DepMap Descartes 0.12 10.77
ISL1 -0.0003253 12262 GTEx DepMap Descartes 0.42 34.90


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.21e-01
Mean rank of genes in gene set: 6814.5
Median rank of genes in gene set: 6915
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CRHBP 0.0006547 515 GTEx DepMap Descartes 0.10 12.28
F8 0.0000625 2439 GTEx DepMap Descartes 0.02 0.46
NR5A2 0.0000305 2886 GTEx DepMap Descartes 0.00 0.01
SHE 0.0000190 3113 GTEx DepMap Descartes 0.01 0.62
TMEM88 0.0000086 3334 GTEx DepMap Descartes 0.11 28.38
HYAL2 -0.0000109 4012 GTEx DepMap Descartes 0.27 12.95
ESM1 -0.0000126 4118 GTEx DepMap Descartes 0.04 1.35
TEK -0.0000257 4846 GTEx DepMap Descartes 0.01 0.09
MMRN2 -0.0000318 5203 GTEx DepMap Descartes 0.01 0.26
GALNT15 -0.0000334 5303 GTEx DepMap Descartes 0.00 NA
SLCO2A1 -0.0000362 5459 GTEx DepMap Descartes 0.00 0.00
MYRIP -0.0000393 5632 GTEx DepMap Descartes 0.01 0.14
NPR1 -0.0000467 6067 GTEx DepMap Descartes 0.00 0.25
PTPRB -0.0000479 6128 GTEx DepMap Descartes 0.03 0.28
PLVAP -0.0000498 6244 GTEx DepMap Descartes 0.07 3.89
CDH5 -0.0000572 6682 GTEx DepMap Descartes 0.04 1.08
KDR -0.0000604 6840 GTEx DepMap Descartes 0.01 0.20
EHD3 -0.0000614 6883 GTEx DepMap Descartes 0.01 0.27
CALCRL -0.0000619 6911 GTEx DepMap Descartes 0.02 0.69
IRX3 -0.0000620 6919 GTEx DepMap Descartes 0.02 1.64
KANK3 -0.0000638 7014 GTEx DepMap Descartes 0.00 0.33
CYP26B1 -0.0000664 7168 GTEx DepMap Descartes 0.02 0.53
TIE1 -0.0000743 7587 GTEx DepMap Descartes 0.01 0.53
FLT4 -0.0000763 7687 GTEx DepMap Descartes 0.01 0.14
SHANK3 -0.0000782 7787 GTEx DepMap Descartes 0.01 0.10
RASIP1 -0.0000806 7903 GTEx DepMap Descartes 0.01 0.33
ROBO4 -0.0000808 7914 GTEx DepMap Descartes 0.02 0.52
PODXL -0.0000873 8231 GTEx DepMap Descartes 0.04 0.81
CLDN5 -0.0000902 8371 GTEx DepMap Descartes 0.11 8.95
CEACAM1 -0.0000908 8407 GTEx DepMap Descartes 0.01 0.33


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.65e-01
Mean rank of genes in gene set: 6669.73
Median rank of genes in gene set: 6505
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DKK2 0.0002703 1171 GTEx DepMap Descartes 0.02 1.33
COL27A1 0.0002212 1345 GTEx DepMap Descartes 0.02 0.57
ABCA6 0.0000079 3354 GTEx DepMap Descartes 0.05 1.19
ADAMTS2 -0.0000084 3894 GTEx DepMap Descartes 0.02 0.65
SCARA5 -0.0000101 3972 GTEx DepMap Descartes 0.00 0.00
EDNRA -0.0000146 4231 GTEx DepMap Descartes 0.01 0.28
ABCC9 -0.0000204 4546 GTEx DepMap Descartes 0.00 0.04
GAS2 -0.0000246 4797 GTEx DepMap Descartes 0.00 0.24
SFRP2 -0.0000311 5164 GTEx DepMap Descartes 0.02 5.61
ITGA11 -0.0000316 5190 GTEx DepMap Descartes 0.00 0.09
HHIP -0.0000330 5277 GTEx DepMap Descartes 0.06 1.51
IGFBP3 -0.0000392 5628 GTEx DepMap Descartes 0.03 1.08
BICC1 -0.0000406 5702 GTEx DepMap Descartes 0.01 0.22
ADAMTSL3 -0.0000443 5906 GTEx DepMap Descartes 0.00 0.01
POSTN -0.0000465 6056 GTEx DepMap Descartes 0.05 3.38
PCDH18 -0.0000468 6071 GTEx DepMap Descartes 0.01 0.29
ACTA2 -0.0000468 6073 GTEx DepMap Descartes 0.20 14.54
LAMC3 -0.0000470 6088 GTEx DepMap Descartes 0.00 0.03
GLI2 -0.0000485 6160 GTEx DepMap Descartes 0.00 0.00
COL6A3 -0.0000500 6253 GTEx DepMap Descartes 0.05 1.08
FREM1 -0.0000503 6269 GTEx DepMap Descartes 0.00 0.06
C7 -0.0000510 6317 GTEx DepMap Descartes 0.01 0.12
LUM -0.0000574 6693 GTEx DepMap Descartes 0.20 13.56
PRRX1 -0.0000583 6745 GTEx DepMap Descartes 0.01 0.57
PAMR1 -0.0000642 7038 GTEx DepMap Descartes 0.01 0.58
LOX -0.0000685 7284 GTEx DepMap Descartes 0.02 0.77
LRRC17 -0.0000696 7350 GTEx DepMap Descartes 0.01 0.88
CD248 -0.0000700 7371 GTEx DepMap Descartes 0.02 1.38
RSPO3 -0.0000704 7384 GTEx DepMap Descartes 0.00 NA
DCN -0.0000714 7450 GTEx DepMap Descartes 0.23 10.85


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8283.95
Median rank of genes in gene set: 8830
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ST18 0.0001826 1534 GTEx DepMap Descartes 0.02 0.79
PENK 0.0000142 3220 GTEx DepMap Descartes 0.00 0.47
SLC35F3 -0.0000130 4142 GTEx DepMap Descartes 0.00 0.20
SORCS3 -0.0000168 4359 GTEx DepMap Descartes 0.01 0.36
CNTN3 -0.0000301 5097 GTEx DepMap Descartes 0.00 0.10
LAMA3 -0.0000320 5222 GTEx DepMap Descartes 0.00 0.05
CDH18 -0.0000351 5384 GTEx DepMap Descartes 0.01 0.37
TBX20 -0.0000359 5438 GTEx DepMap Descartes 0.00 0.27
SLC24A2 -0.0000428 5815 GTEx DepMap Descartes 0.00 0.02
DGKK -0.0000456 5998 GTEx DepMap Descartes 0.01 0.38
GRM7 -0.0000474 6101 GTEx DepMap Descartes 0.00 0.00
EML6 -0.0000516 6345 GTEx DepMap Descartes 0.01 0.09
TIAM1 -0.0000517 6347 GTEx DepMap Descartes 0.09 2.63
GALNTL6 -0.0000704 7395 GTEx DepMap Descartes 0.00 0.38
PCSK2 -0.0000752 7635 GTEx DepMap Descartes 0.00 0.16
CDH12 -0.0000756 7655 GTEx DepMap Descartes 0.01 0.16
AGBL4 -0.0000914 8443 GTEx DepMap Descartes 0.01 0.19
NTNG1 -0.0000978 8751 GTEx DepMap Descartes 0.03 0.96
TENM1 -0.0000987 8795 GTEx DepMap Descartes 0.00 NA
ROBO1 -0.0001006 8865 GTEx DepMap Descartes 0.07 1.54
SPOCK3 -0.0001024 8932 GTEx DepMap Descartes 0.01 0.26
PACRG -0.0001059 9064 GTEx DepMap Descartes 0.01 1.55
GRID2 -0.0001119 9322 GTEx DepMap Descartes 0.02 0.27
CCSER1 -0.0001191 9599 GTEx DepMap Descartes 0.02 NA
SLC18A1 -0.0001237 9753 GTEx DepMap Descartes 0.02 1.23
KSR2 -0.0001250 9803 GTEx DepMap Descartes 0.01 0.12
FGF14 -0.0001254 9820 GTEx DepMap Descartes 0.04 0.74
UNC80 -0.0001323 10037 GTEx DepMap Descartes 0.04 0.71
MGAT4C -0.0001460 10394 GTEx DepMap Descartes 0.02 0.11
FAM155A -0.0001542 10583 GTEx DepMap Descartes 0.06 1.28


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.05e-02
Mean rank of genes in gene set: 5233.14
Median rank of genes in gene set: 4098
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BLVRB 0.0029151 43 GTEx DepMap Descartes 4.01 675.54
CAT 0.0005845 602 GTEx DepMap Descartes 0.54 48.69
SPECC1 0.0001148 1921 GTEx DepMap Descartes 0.11 2.69
TRAK2 0.0000873 2154 GTEx DepMap Descartes 0.08 2.60
RAPGEF2 0.0000819 2215 GTEx DepMap Descartes 0.24 6.47
FECH 0.0000766 2273 GTEx DepMap Descartes 0.09 2.33
MARCH3 0.0000682 2374 GTEx DepMap Descartes 0.08 NA
ABCB10 0.0000646 2419 GTEx DepMap Descartes 0.06 2.54
GCLC 0.0000445 2682 GTEx DepMap Descartes 0.18 10.33
CPOX 0.0000374 2782 GTEx DepMap Descartes 0.05 3.68
SELENBP1 0.0000316 2870 GTEx DepMap Descartes 0.01 0.67
SLC4A1 0.0000183 3125 GTEx DepMap Descartes 0.01 0.34
MICAL2 -0.0000095 3945 GTEx DepMap Descartes 0.03 1.28
SLC25A21 -0.0000117 4063 GTEx DepMap Descartes 0.00 0.00
RHD -0.0000123 4098 GTEx DepMap Descartes 0.00 0.00
XPO7 -0.0000177 4409 GTEx DepMap Descartes 0.11 4.20
RGS6 -0.0000194 4488 GTEx DepMap Descartes 0.00 0.05
GYPC -0.0000228 4691 GTEx DepMap Descartes 0.98 123.64
ALAS2 -0.0000371 5522 GTEx DepMap Descartes 0.00 0.24
TFR2 -0.0000667 7181 GTEx DepMap Descartes 0.03 1.44
SPTB -0.0000798 7874 GTEx DepMap Descartes 0.01 0.26
ANK1 -0.0000902 8376 GTEx DepMap Descartes 0.02 0.28
TMCC2 -0.0000970 8717 GTEx DepMap Descartes 0.01 0.51
SOX6 -0.0001140 9405 GTEx DepMap Descartes 0.01 0.10
DENND4A -0.0001250 9805 GTEx DepMap Descartes 0.13 3.46
SLC25A37 -0.0001261 9847 GTEx DepMap Descartes 0.22 11.69
SNCA -0.0001557 10620 GTEx DepMap Descartes 0.17 10.62
EPB41 -0.0001880 11223 GTEx DepMap Descartes 0.14 4.22
TSPAN5 -0.0002722 12037 GTEx DepMap Descartes 0.11 4.41
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.58e-13
Mean rank of genes in gene set: 2037.63
Median rank of genes in gene set: 344
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CTSD 0.0057705 4 GTEx DepMap Descartes 29.70 3587.56
CTSB 0.0049809 10 GTEx DepMap Descartes 20.73 1419.88
SPP1 0.0044444 13 GTEx DepMap Descartes 144.70 26388.04
CTSS 0.0028093 46 GTEx DepMap Descartes 6.25 304.47
ABCA1 0.0025897 51 GTEx DepMap Descartes 1.26 29.50
LGMN 0.0024397 57 GTEx DepMap Descartes 6.06 613.53
CD14 0.0023524 62 GTEx DepMap Descartes 9.36 1334.13
CTSC 0.0016730 140 GTEx DepMap Descartes 6.69 200.28
MSR1 0.0015839 155 GTEx DepMap Descartes 1.03 71.34
ADAP2 0.0014632 182 GTEx DepMap Descartes 1.01 87.71
SLCO2B1 0.0012929 217 GTEx DepMap Descartes 0.87 34.23
HCK 0.0012313 233 GTEx DepMap Descartes 0.62 55.55
IFNGR1 0.0011786 252 GTEx DepMap Descartes 1.20 102.73
CD74 0.0010175 302 GTEx DepMap Descartes 41.32 2497.02
SLC1A3 0.0010140 304 GTEx DepMap Descartes 0.40 21.40
CD163 0.0009878 318 GTEx DepMap Descartes 1.65 78.66
TGFBI 0.0009665 324 GTEx DepMap Descartes 1.48 72.48
CYBB 0.0009545 327 GTEx DepMap Descartes 1.31 62.66
MS4A4A 0.0009469 330 GTEx DepMap Descartes 2.62 326.17
MARCH1 0.0008708 358 GTEx DepMap Descartes 0.62 NA
RGL1 0.0008259 394 GTEx DepMap Descartes 0.32 14.06
CSF1R 0.0007202 462 GTEx DepMap Descartes 1.19 66.71
MERTK 0.0006757 497 GTEx DepMap Descartes 0.38 22.46
CST3 0.0003793 904 GTEx DepMap Descartes 15.58 959.23
FGD2 0.0002658 1192 GTEx DepMap Descartes 0.15 5.05
ITPR2 0.0002204 1349 GTEx DepMap Descartes 0.37 5.94
PTPRE 0.0001508 1695 GTEx DepMap Descartes 0.64 23.32
AXL 0.0001234 1842 GTEx DepMap Descartes 0.69 29.61
RBPJ 0.0001190 1882 GTEx DepMap Descartes 0.83 32.22
ATP8B4 0.0001109 1950 GTEx DepMap Descartes 0.09 3.46


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.25e-01
Mean rank of genes in gene set: 7058.75
Median rank of genes in gene set: 7355.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
VIM 0.0020377 90 GTEx DepMap Descartes 15.39 1296.07
KCTD12 0.0009258 339 GTEx DepMap Descartes 0.75 28.24
GAS7 0.0005965 585 GTEx DepMap Descartes 0.25 7.44
VCAN 0.0005015 704 GTEx DepMap Descartes 0.80 21.22
EDNRB 0.0002181 1359 GTEx DepMap Descartes 0.08 4.76
STARD13 0.0001039 2005 GTEx DepMap Descartes 0.06 2.26
LAMC1 0.0000436 2690 GTEx DepMap Descartes 0.09 2.31
IL1RAPL2 -0.0000018 3628 GTEx DepMap Descartes 0.00 0.00
MDGA2 -0.0000126 4117 GTEx DepMap Descartes 0.00 0.00
PAG1 -0.0000127 4123 GTEx DepMap Descartes 0.30 6.70
HMGA2 -0.0000158 4305 GTEx DepMap Descartes 0.00 0.03
PMP22 -0.0000283 5002 GTEx DepMap Descartes 0.70 78.53
ADAMTS5 -0.0000293 5046 GTEx DepMap Descartes 0.02 0.47
IL1RAPL1 -0.0000368 5508 GTEx DepMap Descartes 0.00 0.35
MPZ -0.0000465 6055 GTEx DepMap Descartes 0.03 3.38
ERBB4 -0.0000466 6064 GTEx DepMap Descartes 0.02 0.53
PLCE1 -0.0000536 6468 GTEx DepMap Descartes 0.04 0.66
NRXN3 -0.0000536 6469 GTEx DepMap Descartes 0.01 0.13
PLP1 -0.0000549 6548 GTEx DepMap Descartes 0.04 2.04
TRPM3 -0.0000561 6617 GTEx DepMap Descartes 0.00 0.03
GRIK3 -0.0000611 6878 GTEx DepMap Descartes 0.01 0.12
COL25A1 -0.0000676 7238 GTEx DepMap Descartes 0.01 0.07
XKR4 -0.0000720 7473 GTEx DepMap Descartes 0.01 0.08
MARCKS -0.0000730 7523 GTEx DepMap Descartes 5.29 252.42
EGFLAM -0.0000770 7722 GTEx DepMap Descartes 0.02 0.53
LRRTM4 -0.0000853 8120 GTEx DepMap Descartes 0.01 0.28
PTPRZ1 -0.0000878 8251 GTEx DepMap Descartes 0.00 0.03
SLC35F1 -0.0000909 8418 GTEx DepMap Descartes 0.02 0.64
ERBB3 -0.0000914 8441 GTEx DepMap Descartes 0.01 0.40
COL18A1 -0.0000931 8532 GTEx DepMap Descartes 0.14 2.94


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.32e-06
Mean rank of genes in gene set: 3921.29
Median rank of genes in gene set: 1591
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CD84 0.0026399 50 GTEx DepMap Descartes 1.09 29.32
PLEK 0.0017452 126 GTEx DepMap Descartes 2.05 168.86
ACTB 0.0016508 145 GTEx DepMap Descartes 37.41 3710.50
LIMS1 0.0016146 150 GTEx DepMap Descartes 1.90 98.99
FERMT3 0.0013195 209 GTEx DepMap Descartes 0.77 66.29
TMSB4X 0.0011671 260 GTEx DepMap Descartes 133.63 16229.86
TPM4 0.0011052 278 GTEx DepMap Descartes 2.23 112.05
CD9 0.0008404 384 GTEx DepMap Descartes 1.41 182.71
UBASH3B 0.0008351 387 GTEx DepMap Descartes 0.17 6.78
FLNA 0.0006747 498 GTEx DepMap Descartes 0.74 21.41
TLN1 0.0006404 534 GTEx DepMap Descartes 0.87 21.40
RAP1B 0.0006136 564 GTEx DepMap Descartes 1.08 18.02
ZYX 0.0005900 597 GTEx DepMap Descartes 0.66 61.77
GSN 0.0005311 664 GTEx DepMap Descartes 1.55 48.78
PSTPIP2 0.0004377 805 GTEx DepMap Descartes 0.16 12.06
SPN 0.0003661 925 GTEx DepMap Descartes 0.17 4.61
STOM 0.0003578 940 GTEx DepMap Descartes 0.54 36.86
ACTN1 0.0003177 1035 GTEx DepMap Descartes 0.43 18.79
TGFB1 0.0003097 1053 GTEx DepMap Descartes 0.82 64.63
MCTP1 0.0002775 1143 GTEx DepMap Descartes 0.10 3.59
MYH9 0.0001856 1514 GTEx DepMap Descartes 0.49 14.30
ITGB3 0.0001717 1587 GTEx DepMap Descartes 0.00 0.19
SLC2A3 0.0001695 1591 GTEx DepMap Descartes 0.72 36.36
GP1BA 0.0000995 2045 GTEx DepMap Descartes 0.00 0.23
FLI1 0.0000659 2399 GTEx DepMap Descartes 0.13 5.39
HIPK2 0.0000033 3459 GTEx DepMap Descartes 0.22 3.35
SLC24A3 -0.0000077 3860 GTEx DepMap Descartes 0.00 0.21
ARHGAP6 -0.0000210 4584 GTEx DepMap Descartes 0.01 0.11
TUBB1 -0.0000273 4943 GTEx DepMap Descartes 0.00 0.06
P2RX1 -0.0000416 5764 GTEx DepMap Descartes 0.01 0.94


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 7558.9
Median rank of genes in gene set: 10256.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0012926 218 GTEx DepMap Descartes 101.52 8715.55
LCP1 0.0007723 421 GTEx DepMap Descartes 1.51 84.59
ARHGDIB 0.0006728 500 GTEx DepMap Descartes 4.16 730.52
CD44 0.0006484 526 GTEx DepMap Descartes 1.79 84.85
MSN 0.0005720 618 GTEx DepMap Descartes 0.99 57.14
PLEKHA2 0.0004093 853 GTEx DepMap Descartes 0.25 10.33
WIPF1 0.0002813 1134 GTEx DepMap Descartes 0.65 29.83
TMSB10 0.0000758 2283 GTEx DepMap Descartes 54.29 23427.35
ITPKB 0.0000625 2440 GTEx DepMap Descartes 0.05 1.62
MBNL1 0.0000622 2445 GTEx DepMap Descartes 0.55 19.24
SP100 0.0000574 2503 GTEx DepMap Descartes 0.47 17.38
IKZF1 0.0000430 2700 GTEx DepMap Descartes 0.29 10.77
DOCK10 0.0000117 3282 GTEx DepMap Descartes 0.23 7.06
ARID5B -0.0000012 3603 GTEx DepMap Descartes 0.35 10.59
PTPRC -0.0000017 3620 GTEx DepMap Descartes 1.41 55.75
RCSD1 -0.0000303 5116 GTEx DepMap Descartes 0.25 10.47
CELF2 -0.0000562 6623 GTEx DepMap Descartes 0.53 14.81
PITPNC1 -0.0000757 7659 GTEx DepMap Descartes 0.16 5.06
MCTP2 -0.0001134 9386 GTEx DepMap Descartes 0.01 0.22
ARHGAP15 -0.0001191 9598 GTEx DepMap Descartes 0.22 14.52
CCL5 -0.0001396 10233 GTEx DepMap Descartes 0.63 91.53
SAMD3 -0.0001415 10280 GTEx DepMap Descartes 0.01 0.43
PRKCH -0.0001509 10507 GTEx DepMap Descartes 0.07 3.92
BACH2 -0.0001569 10646 GTEx DepMap Descartes 0.05 1.13
SORL1 -0.0001572 10654 GTEx DepMap Descartes 0.28 5.99
ABLIM1 -0.0001886 11235 GTEx DepMap Descartes 0.07 1.89
SCML4 -0.0001893 11245 GTEx DepMap Descartes 0.02 1.08
RAP1GAP2 -0.0001895 11248 GTEx DepMap Descartes 0.05 1.54
ETS1 -0.0001933 11301 GTEx DepMap Descartes 0.07 1.53
BCL2 -0.0001934 11302 GTEx DepMap Descartes 0.19 5.48


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.26e-04
Mean rank of genes in gene set: 346.4
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FTH1 0.0035559 31 GTEx DepMap Descartes 154.58 27938.67
TYROBP 0.0028541 44 GTEx DepMap Descartes 22.46 8139.71
ACTB 0.0016508 145 GTEx DepMap Descartes 37.41 3710.50
SRGN 0.0010305 287 GTEx DepMap Descartes 12.52 2377.60
S100A6 0.0002574 1225 GTEx DepMap Descartes 4.80 1617.56


Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.90e-03
Mean rank of genes in gene set: 220.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TYROBP 0.0028541 44 GTEx DepMap Descartes 22.46 8139.71
SAT1 0.0014530 184 GTEx DepMap Descartes 29.48 5542.64
NEAT1 0.0007572 434 GTEx DepMap Descartes 8.86 90.32


DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.72e-03
Mean rank of genes in gene set: 986
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
MMP9 0.0043965 14 GTEx DepMap Descartes 2.77 194.81
CST3 0.0003793 904 GTEx DepMap Descartes 15.58 959.23
AGRP 0.0000999 2040 GTEx DepMap Descartes 0.01 5.71