Program: 39. M-MDSC.

Program: 39. M-MDSC.



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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 IL1B 0.0135789 interleukin 1 beta GTEx DepMap Descartes 14.75 2110.19
2 CD300E 0.0109082 CD300e molecule GTEx DepMap Descartes 0.20 16.77
3 EREG 0.0105588 epiregulin GTEx DepMap Descartes 1.73 111.39
4 STXBP2 0.0098825 syntaxin binding protein 2 GTEx DepMap Descartes 1.01 140.16
5 G0S2 0.0094955 G0/G1 switch 2 GTEx DepMap Descartes 10.05 2964.87
6 PLAUR 0.0088697 plasminogen activator, urokinase receptor GTEx DepMap Descartes 7.68 1152.86
7 LST1 0.0088641 leukocyte specific transcript 1 GTEx DepMap Descartes 5.55 723.43
8 SOD2 0.0085002 superoxide dismutase 2 GTEx DepMap Descartes 5.75 97.25
9 S100A4 0.0080454 S100 calcium binding protein A4 GTEx DepMap Descartes 5.73 1960.80
10 C5AR1 0.0079151 complement C5a receptor 1 GTEx DepMap Descartes 1.84 198.21
11 NLRP3 0.0077743 NLR family pyrin domain containing 3 GTEx DepMap Descartes 0.80 47.77
12 CXCL2 0.0077718 C-X-C motif chemokine ligand 2 GTEx DepMap Descartes 8.05 1745.69
13 AIF1 0.0077160 allograft inflammatory factor 1 GTEx DepMap Descartes 10.33 1873.72
14 FTH1 0.0077057 ferritin heavy chain 1 GTEx DepMap Descartes 168.11 31442.59
15 NCF2 0.0071794 neutrophil cytosolic factor 2 GTEx DepMap Descartes 0.66 64.23
16 CFP 0.0069465 complement factor properdin GTEx DepMap Descartes 0.46 26.40
17 NFKBIA 0.0068344 NFKB inhibitor alpha GTEx DepMap Descartes 22.06 3031.79
18 SRGN 0.0068017 serglycin GTEx DepMap Descartes 16.42 3137.98
19 HBEGF 0.0067783 heparin binding EGF like growth factor GTEx DepMap Descartes 1.28 132.41
20 SPI1 0.0064920 Spi-1 proto-oncogene GTEx DepMap Descartes 2.44 389.45
21 S100A11 0.0064589 S100 calcium binding protein A11 GTEx DepMap Descartes 16.67 6811.70
22 IL1RN 0.0063958 interleukin 1 receptor antagonist GTEx DepMap Descartes 2.26 283.97
23 FCER1G 0.0063692 Fc epsilon receptor Ig GTEx DepMap Descartes 11.37 4400.53
24 CTSS 0.0063267 cathepsin S GTEx DepMap Descartes 5.89 298.06
25 NAMPT 0.0063130 nicotinamide phosphoribosyltransferase GTEx DepMap Descartes 3.76 208.58
26 CXCL3 0.0063027 C-X-C motif chemokine ligand 3 GTEx DepMap Descartes 7.02 1012.54
27 COTL1 0.0062697 coactosin like F-actin binding protein 1 GTEx DepMap Descartes 5.40 228.89
28 PTGS2 0.0062290 prostaglandin-endoperoxide synthase 2 GTEx DepMap Descartes 1.40 77.19
29 TSPO 0.0062101 translocator protein GTEx DepMap Descartes 2.87 621.92
30 TYROBP 0.0061054 transmembrane immune signaling adaptor TYROBP GTEx DepMap Descartes 22.81 8449.38
31 CEBPB 0.0059287 CCAAT enhancer binding protein beta GTEx DepMap Descartes 3.27 406.14
32 SLC11A1 0.0059037 solute carrier family 11 member 1 GTEx DepMap Descartes 0.67 33.91
33 AQP9 0.0058680 aquaporin 9 GTEx DepMap Descartes 0.36 38.29
34 TNFAIP2 0.0058637 TNF alpha induced protein 2 GTEx DepMap Descartes 0.98 45.42
35 IER3 0.0057302 immediate early response 3 GTEx DepMap Descartes 13.30 2169.86
36 EMP3 0.0057053 epithelial membrane protein 3 GTEx DepMap Descartes 2.00 647.48
37 KYNU 0.0056336 kynureninase GTEx DepMap Descartes 0.41 6.02
38 PYCARD 0.0056244 PYD and CARD domain containing GTEx DepMap Descartes 2.48 463.13
39 AREG 0.0056061 amphiregulin GTEx DepMap Descartes 3.10 624.87
40 SLC7A7 0.0054914 solute carrier family 7 member 7 GTEx DepMap Descartes 0.88 61.78
41 SH3BGRL3 0.0054875 SH3 domain binding glutamate rich protein like 3 GTEx DepMap Descartes 10.63 3210.29
42 TNFSF13B 0.0052955 TNF superfamily member 13b GTEx DepMap Descartes 1.96 158.97
43 RILPL2 0.0049549 Rab interacting lysosomal protein like 2 GTEx DepMap Descartes 1.93 67.74
44 GPBAR1 0.0049490 G protein-coupled bile acid receptor 1 GTEx DepMap Descartes 0.12 13.29
45 CYBB 0.0049274 cytochrome b-245 beta chain GTEx DepMap Descartes 1.44 72.47
46 LGALS2 0.0048956 galectin 2 GTEx DepMap Descartes 2.52 845.99
47 S100A6 0.0048917 S100 calcium binding protein A6 GTEx DepMap Descartes 7.50 2854.00
48 NFKBIZ 0.0048017 NFKB inhibitor zeta GTEx DepMap Descartes 2.01 116.65
49 STX11 0.0047978 syntaxin 11 GTEx DepMap Descartes 1.11 42.78
50 PILRA 0.0047874 paired immunoglobin like type 2 receptor alpha GTEx DepMap Descartes 1.05 184.41


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UMAP plots showing activity of gene expression program identified in GEP 39. M-MDSC:

Interactive UMAP Plot
Interactive Boxplot

CNV Data procured from inferCNV.
 Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
    The top cells expressing this GEP (purple)
    Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_DENDRITIC_CELLS 1.25e-64 398.21 199.46 8.37e-62 8.37e-62
36IL1B, EREG, STXBP2, G0S2, PLAUR, LST1, SOD2, S100A4, C5AR1, NLRP3, CXCL2, AIF1, FTH1, NCF2, CFP, NFKBIA, SRGN, SPI1, FCER1G, CTSS, NAMPT, COTL1, PTGS2, TYROBP, CEBPB, SLC11A1, TNFAIP2, EMP3, PYCARD, SH3BGRL3, TNFSF13B, CYBB, LGALS2, NFKBIZ, STX11, PILRA
 117
AIZARANI_LIVER_C23_KUPFFER_CELLS_3 5.73e-45 117.36 62.75 1.92e-42 3.84e-42
32IL1B, CD300E, EREG, PLAUR, LST1, SOD2, S100A4, C5AR1, AIF1, FTH1, NCF2, CFP, NFKBIA, SRGN, S100A11, FCER1G, CTSS, NAMPT, COTL1, PTGS2, TSPO, TYROBP, SLC11A1, TNFAIP2, AREG, SLC7A7, SH3BGRL3, TNFSF13B, RILPL2, CYBB, S100A6, PILRA
 221
AIZARANI_LIVER_C18_NK_NKT_CELLS_5 3.31e-30 90.33 47.26 2.47e-28 2.22e-27
21IL1B, PLAUR, LST1, C5AR1, AIF1, FTH1, NCF2, HBEGF, S100A11, FCER1G, CTSS, COTL1, TYROBP, CEBPB, SLC11A1, TNFAIP2, IER3, AREG, SLC7A7, RILPL2, CYBB
 121
AIZARANI_LIVER_C25_KUPFFER_CELLS_4 3.99e-34 83.68 45.03 5.36e-32 2.68e-31
25IL1B, EREG, PLAUR, LST1, C5AR1, NLRP3, AIF1, FTH1, NCF2, SRGN, HBEGF, S100A11, IL1RN, FCER1G, CTSS, NAMPT, CXCL3, COTL1, TYROBP, SLC11A1, IER3, AREG, TNFSF13B, RILPL2, CYBB
 174
FAN_EMBRYONIC_CTX_BRAIN_MYELOID 7.31e-29 76.59 40.27 4.09e-27 4.90e-26
21CD300E, STXBP2, PLAUR, LST1, S100A4, C5AR1, CFP, NFKBIA, SPI1, S100A11, CTSS, NAMPT, COTL1, PTGS2, CEBPB, TNFAIP2, EMP3, TNFSF13B, GPBAR1, S100A6, NFKBIZ
 139
RUBENSTEIN_SKELETAL_MUSCLE_MYELOID_CELLS 1.06e-36 64.64 34.93 1.78e-34 7.13e-34
31IL1B, STXBP2, PLAUR, LST1, SOD2, S100A4, C5AR1, AIF1, FTH1, CFP, NFKBIA, SRGN, SPI1, S100A11, FCER1G, CTSS, NAMPT, COTL1, TSPO, TYROBP, CEBPB, IER3, EMP3, PYCARD, SH3BGRL3, TNFSF13B, CYBB, S100A6, NFKBIZ, STX11, PILRA
 347
TRAVAGLINI_LUNG_NONCLASSICAL_MONOCYTE_CELL 3.47e-28 62.21 33.10 1.79e-26 2.33e-25
22CD300E, STXBP2, LST1, C5AR1, FTH1, NCF2, CFP, SPI1, S100A11, FCER1G, CTSS, COTL1, TYROBP, CEBPB, SLC11A1, KYNU, SLC7A7, TNFSF13B, GPBAR1, CYBB, NFKBIZ, PILRA
 180
TRAVAGLINI_LUNG_OLR1_CLASSICAL_MONOCYTE_CELL 2.81e-38 57.61 29.32 6.28e-36 1.89e-35
38IL1B, CD300E, EREG, STXBP2, G0S2, PLAUR, LST1, SOD2, C5AR1, NLRP3, CXCL2, AIF1, FTH1, NCF2, CFP, NFKBIA, SRGN, HBEGF, SPI1, S100A11, IL1RN, FCER1G, CTSS, NAMPT, CXCL3, PTGS2, TYROBP, CEBPB, SLC11A1, AQP9, TNFAIP2, IER3, EMP3, KYNU, RILPL2, CYBB, S100A6, STX11
 726
TRAVAGLINI_LUNG_CLASSICAL_MONOCYTE_CELL 3.16e-29 51.02 27.68 2.12e-27 2.12e-26
25CD300E, STXBP2, S100A4, C5AR1, NLRP3, NCF2, CFP, SPI1, FCER1G, CTSS, COTL1, TSPO, TYROBP, CEBPB, SLC11A1, TNFAIP2, KYNU, PYCARD, SLC7A7, TNFSF13B, GPBAR1, CYBB, LGALS2, S100A6, PILRA
 270
CUI_DEVELOPING_HEART_C8_MACROPHAGE 5.01e-29 50.00 27.16 3.06e-27 3.36e-26
25STXBP2, PLAUR, LST1, SOD2, S100A4, C5AR1, NLRP3, AIF1, NCF2, NFKBIA, SRGN, HBEGF, SPI1, FCER1G, CTSS, NAMPT, COTL1, TYROBP, CEBPB, IER3, PYCARD, SH3BGRL3, RILPL2, CYBB, PILRA
 275
GAO_LARGE_INTESTINE_24W_C11_PANETH_LIKE_CELL 1.57e-30 49.27 26.85 1.32e-28 1.05e-27
27IL1B, CD300E, PLAUR, LST1, SOD2, C5AR1, NLRP3, CXCL2, AIF1, NCF2, CFP, SRGN, SPI1, IL1RN, FCER1G, NAMPT, CXCL3, COTL1, PTGS2, TYROBP, CEBPB, TNFAIP2, KYNU, TNFSF13B, RILPL2, CYBB, STX11
 325
TRAVAGLINI_LUNG_MACROPHAGE_CELL 2.22e-25 50.18 26.70 1.06e-23 1.49e-22
21IL1B, PLAUR, SOD2, CXCL2, FTH1, NCF2, HBEGF, S100A11, IL1RN, FCER1G, CTSS, CXCL3, TSPO, TYROBP, SLC11A1, AQP9, TNFAIP2, KYNU, SLC7A7, CYBB, PILRA
 201
AIZARANI_LIVER_C31_KUPFFER_CELLS_5 3.07e-19 50.93 25.06 1.21e-17 2.06e-16
15IL1B, CD300E, PLAUR, LST1, C5AR1, AIF1, S100A11, IL1RN, FCER1G, CTSS, NAMPT, COTL1, TYROBP, SLC11A1, CYBB
 120
TRAVAGLINI_LUNG_EREG_DENDRITIC_CELL 3.71e-33 44.50 23.92 4.15e-31 2.49e-30
33IL1B, CD300E, EREG, G0S2, PLAUR, LST1, SOD2, C5AR1, NLRP3, CXCL2, AIF1, FTH1, NCF2, SRGN, HBEGF, SPI1, S100A11, IL1RN, FCER1G, NAMPT, CXCL3, COTL1, TYROBP, CEBPB, SLC11A1, IER3, EMP3, KYNU, AREG, TNFSF13B, RILPL2, CYBB, S100A6
 579
FAN_OVARY_CL13_MONOCYTE_MACROPHAGE 2.43e-31 43.84 23.87 2.33e-29 1.63e-28
30G0S2, PLAUR, LST1, SOD2, S100A4, CXCL2, AIF1, FTH1, CFP, NFKBIA, SRGN, SPI1, S100A11, FCER1G, CTSS, NAMPT, COTL1, TSPO, TYROBP, CEBPB, IER3, EMP3, KYNU, PYCARD, SH3BGRL3, TNFSF13B, RILPL2, LGALS2, S100A6, STX11
 458
AIZARANI_LIVER_C6_KUPFFER_CELLS_2 3.22e-24 43.72 23.28 1.44e-22 2.16e-21
21IL1B, LST1, C5AR1, AIF1, FTH1, CFP, SPI1, S100A11, FCER1G, CTSS, COTL1, TYROBP, CEBPB, SLC11A1, TNFAIP2, IER3, PYCARD, SLC7A7, TNFSF13B, CYBB, PILRA
 228
AIZARANI_LIVER_C2_KUPFFER_CELLS_1 4.34e-22 42.31 22.14 1.82e-20 2.91e-19
19IL1B, PLAUR, LST1, C5AR1, NLRP3, AIF1, FTH1, NCF2, SRGN, S100A11, FCER1G, CTSS, COTL1, TYROBP, IER3, AREG, TNFSF13B, RILPL2, CYBB
 200
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MAST_CELLS 2.50e-13 48.00 20.51 6.45e-12 1.68e-10
10PLAUR, FTH1, NFKBIA, SRGN, FCER1G, PTGS2, TYROBP, EMP3, AREG, NFKBIZ
 75
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MACROPHAGES 5.54e-13 43.92 18.85 1.28e-11 3.72e-10
10IL1B, PLAUR, LST1, AIF1, SRGN, SPI1, FCER1G, CTSS, COTL1, TYROBP
 81
MENON_FETAL_KIDNEY_10_IMMUNE_CELLS 7.12e-13 42.73 18.35 1.59e-11 4.78e-10
10LST1, S100A4, AIF1, SRGN, S100A11, COTL1, TYROBP, SH3BGRL3, CYBB, S100A6
 83

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_TNFA_SIGNALING_VIA_NFKB 7.03e-16 28.93 14.43 3.52e-14 3.52e-14
15IL1B, G0S2, PLAUR, SOD2, CXCL2, NFKBIA, HBEGF, NAMPT, CXCL3, PTGS2, CEBPB, TNFAIP2, IER3, KYNU, AREG
 200
HALLMARK_INFLAMMATORY_RESPONSE 2.35e-10 18.65 8.48 5.89e-09 1.18e-08
11IL1B, EREG, PLAUR, C5AR1, NLRP3, NFKBIA, HBEGF, NAMPT, AQP9, EMP3, CYBB
 200
HALLMARK_KRAS_SIGNALING_UP 9.73e-07 12.40 4.96 1.62e-05 4.87e-05
8IL1B, EREG, G0S2, PLAUR, HBEGF, FCER1G, CTSS, PTGS2
 200
HALLMARK_ALLOGRAFT_REJECTION 1.19e-05 10.54 3.95 1.48e-04 5.94e-04
7IL1B, EREG, NLRP3, CFP, SRGN, SPI1, CTSS
 200
HALLMARK_APOPTOSIS 4.10e-04 8.90 2.72 4.10e-03 2.05e-02
5IL1B, EREG, SOD2, TSPO, IER3
 161
HALLMARK_INTERFERON_GAMMA_RESPONSE 1.08e-03 7.12 2.18 7.71e-03 5.40e-02
5SOD2, NFKBIA, NAMPT, PTGS2, TNFAIP2
 200
HALLMARK_COMPLEMENT 1.08e-03 7.12 2.18 7.71e-03 5.40e-02
5PLAUR, FCER1G, CTSS, CEBPB, KYNU
 200
HALLMARK_UV_RESPONSE_UP 2.41e-02 5.15 1.01 1.51e-01 1.00e+00
3SOD2, CXCL2, NFKBIA
 158
HALLMARK_CHOLESTEROL_HOMEOSTASIS 3.47e-02 7.23 0.84 1.78e-01 1.00e+00
2PLAUR, S100A11
 74
HALLMARK_HYPOXIA 4.35e-02 4.05 0.80 1.78e-01 1.00e+00
3PLAUR, S100A4, IER3
 200
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 4.35e-02 4.05 0.80 1.78e-01 1.00e+00
3PLAUR, EMP3, AREG
 200
HALLMARK_P53_PATHWAY 4.35e-02 4.05 0.80 1.78e-01 1.00e+00
3S100A4, HBEGF, IER3
 200
HALLMARK_IL6_JAK_STAT3_SIGNALING 4.64e-02 6.13 0.71 1.78e-01 1.00e+00
2IL1B, CXCL3
 87
HALLMARK_PEROXISOME 6.35e-02 5.11 0.59 2.27e-01 1.00e+00
2SOD2, TSPO
 104
HALLMARK_MTORC1_SIGNALING 1.85e-01 2.63 0.31 4.86e-01 1.00e+00
2CFP, NAMPT
 200
HALLMARK_XENOBIOTIC_METABOLISM 1.85e-01 2.63 0.31 4.86e-01 1.00e+00
2AQP9, KYNU
 200
HALLMARK_ANGIOGENESIS 1.34e-01 7.29 0.18 4.46e-01 1.00e+00
1S100A4
 36
HALLMARK_APICAL_SURFACE 1.61e-01 5.93 0.14 4.86e-01 1.00e+00
1PLAUR
 44
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 1.77e-01 5.31 0.13 4.86e-01 1.00e+00
1SOD2
 49
HALLMARK_BILE_ACID_METABOLISM 3.59e-01 2.30 0.06 8.61e-01 1.00e+00
1AQP9
 112

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 4.36e-06 24.32 7.27 8.10e-04 8.10e-04
5IL1B, NLRP3, CXCL2, NFKBIA, PYCARD
 62
KEGG_LEISHMANIA_INFECTION 1.84e-04 15.97 4.06 1.71e-02 3.42e-02
4IL1B, NCF2, NFKBIA, PTGS2
 72
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 1.33e-03 15.33 2.96 8.26e-02 2.48e-01
3IL1B, NFKBIA, PYCARD
 55
KEGG_ERBB_SIGNALING_PATHWAY 4.89e-03 9.50 1.85 2.28e-01 9.10e-01
3EREG, HBEGF, AREG
 87
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 1.96e-02 4.16 1.08 7.28e-01 1.00e+00
4IL1B, CXCL2, CXCL3, TNFSF13B
 265
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 2.97e-02 7.89 0.91 8.10e-01 1.00e+00
2NFKBIA, HBEGF
 68
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 3.05e-02 7.77 0.90 8.10e-01 1.00e+00
2PLAUR, C5AR1
 69
KEGG_CHEMOKINE_SIGNALING_PATHWAY 3.79e-02 4.29 0.85 8.63e-01 1.00e+00
3CXCL2, NFKBIA, CXCL3
 189
KEGG_SMALL_CELL_LUNG_CANCER 4.36e-02 6.35 0.74 8.63e-01 1.00e+00
2NFKBIA, PTGS2
 84
KEGG_APOPTOSIS 4.64e-02 6.13 0.71 8.63e-01 1.00e+00
2IL1B, NFKBIA
 87
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 6.14e-02 5.21 0.60 1.00e+00 1.00e+00
2IL1B, NFKBIA
 102
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 7.67e-02 4.57 0.53 1.00e+00 1.00e+00
2NCF2, CYBB
 116
KEGG_LYSOSOME 8.24e-02 4.38 0.51 1.00e+00 1.00e+00
2CTSS, SLC11A1
 121
KEGG_PATHWAYS_IN_CANCER 1.32e-01 2.48 0.49 1.00e+00 1.00e+00
3NFKBIA, SPI1, PTGS2
 325
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.01e-01 3.86 0.45 1.00e+00 1.00e+00
2FCER1G, TYROBP
 137
KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM 9.13e-02 11.08 0.26 1.00e+00 1.00e+00
1NAMPT
 24
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.87e-01 1.93 0.23 1.00e+00 1.00e+00
2C5AR1, TSPO
 272
KEGG_ASTHMA 1.13e-01 8.79 0.21 1.00e+00 1.00e+00
1FCER1G
 30
KEGG_PRION_DISEASES 1.30e-01 7.50 0.18 1.00e+00 1.00e+00
1IL1B
 35
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 1.41e-01 6.89 0.17 1.00e+00 1.00e+00
1STX11
 38

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr1q21 6.42e-02 2.80 0.73 1.00e+00 1.00e+00
4S100A4, S100A11, CTSS, S100A6
 392
chr2q35 8.82e-02 4.20 0.49 1.00e+00 1.00e+00
2SLC11A1, GPBAR1
 126
chr2q14 1.23e-01 3.43 0.40 1.00e+00 1.00e+00
2IL1B, IL1RN
 154
chr6p21 4.27e-01 1.72 0.34 1.00e+00 1.00e+00
3LST1, AIF1, IER3
 467
chr7q22 2.03e-01 2.47 0.29 1.00e+00 1.00e+00
2NAMPT, PILRA
 213
chr19q13 1.00e+00 0.94 0.24 1.00e+00 1.00e+00
4PLAUR, C5AR1, TYROBP, EMP3
 1165
chr22q13 3.33e-01 1.72 0.20 1.00e+00 1.00e+00
2TSPO, LGALS2
 305
chr3q12 1.67e-01 5.67 0.14 1.00e+00 1.00e+00
1NFKBIZ
 46
chr13q33 1.97e-01 4.72 0.12 1.00e+00 1.00e+00
1TNFSF13B
 55
chr14q13 2.09e-01 4.40 0.11 1.00e+00 1.00e+00
1NFKBIA
 59
chr2q22 2.37e-01 3.81 0.09 1.00e+00 1.00e+00
1KYNU
 68
chr1q31 2.46e-01 3.64 0.09 1.00e+00 1.00e+00
1PTGS2
 71
chr6q24 2.49e-01 3.59 0.09 1.00e+00 1.00e+00
1STX11
 72
chrXp21 2.78e-01 3.15 0.08 1.00e+00 1.00e+00
1CYBB
 82
chr16q24 4.03e-01 1.98 0.05 1.00e+00 1.00e+00
1COTL1
 130
chr11p11 4.38e-01 1.77 0.04 1.00e+00 1.00e+00
1SPI1
 145
chr6q25 4.57e-01 1.67 0.04 1.00e+00 1.00e+00
1SOD2
 154
chr1q25 4.70e-01 1.60 0.04 1.00e+00 1.00e+00
1NCF2
 160
chr15q21 4.84e-01 1.54 0.04 1.00e+00 1.00e+00
1AQP9
 167
chr10q22 5.51e-01 1.27 0.03 1.00e+00 1.00e+00
1SRGN
 202

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
CEBPB_02 5.58e-04 6.56 2.26 6.33e-01 6.33e-01
6G0S2, NLRP3, NFKBIA, FCER1G, AQP9, NFKBIZ
 266
ICSBP_Q6 2.97e-03 5.60 1.72 7.32e-01 1.00e+00
5EREG, AIF1, CTSS, KYNU, TNFSF13B
 253
NFKB_Q6 3.23e-03 5.49 1.69 7.32e-01 1.00e+00
5CXCL2, NFKBIA, IL1RN, PTGS2, CYBB
 258
RYTTCCTG_ETS2_B 1.92e-03 3.20 1.48 7.32e-01 1.00e+00
11FTH1, NCF2, SRGN, HBEGF, SPI1, IL1RN, FCER1G, CTSS, TYROBP, TNFSF13B, STX11
 1112
CEBP_Q2 1.38e-02 4.65 1.20 1.00e+00 1.00e+00
4G0S2, NFKBIA, FCER1G, NFKBIZ
 238
IRF_Q6 1.50e-02 4.53 1.17 1.00e+00 1.00e+00
4EREG, KYNU, TNFSF13B, CYBB
 244
ISRE_01 1.69e-02 4.37 1.13 1.00e+00 1.00e+00
4EREG, AIF1, KYNU, TNFSF13B
 253
PEA3_Q6 1.91e-02 4.20 1.09 1.00e+00 1.00e+00
4NLRP3, NCF2, SPI1, CTSS
 263
IRF1_Q6 1.91e-02 4.20 1.09 1.00e+00 1.00e+00
4CTSS, TYROBP, KYNU, TNFSF13B
 263
COUP_01 1.96e-02 4.16 1.08 1.00e+00 1.00e+00
4G0S2, HBEGF, KYNU, SLC7A7
 265
TATAAA_TATA_01 2.43e-02 2.39 1.06 1.00e+00 1.00e+00
10EREG, G0S2, S100A4, NFKBIA, HBEGF, IL1RN, CEBPB, EMP3, AREG, SH3BGRL3
 1317
PSMB5_TARGET_GENES 3.11e-02 3.59 0.93 1.00e+00 1.00e+00
4FTH1, IER3, S100A6, NFKBIZ
 307
SKP2_TARGET_GENES 3.05e-02 7.77 0.90 1.00e+00 1.00e+00
2STXBP2, GPBAR1
 69
HES2_TARGET_GENES 9.37e-02 1.95 0.83 1.00e+00 1.00e+00
9CXCL2, NFKBIA, SRGN, COTL1, PTGS2, AREG, SLC7A7, S100A6, NFKBIZ
 1420
TTANTCA_UNKNOWN 8.80e-02 2.12 0.80 1.00e+00 1.00e+00
7EREG, SOD2, NLRP3, FCER1G, PTGS2, CEBPB, AQP9
 967
SREBP1_02 4.73e-02 6.05 0.70 1.00e+00 1.00e+00
2SPI1, CEBPB
 88
NR0B1_TARGET_GENES 6.27e-02 3.47 0.69 1.00e+00 1.00e+00
3CXCL2, NAMPT, TNFAIP2
 233
ZNF597_TARGET_GENES 1.40e-01 1.96 0.68 1.00e+00 1.00e+00
6SOD2, NCF2, NFKBIA, RILPL2, NFKBIZ, STX11
 877
TEL2_Q6 6.72e-02 3.37 0.67 1.00e+00 1.00e+00
3HBEGF, CTSS, STX11
 240
TBP_01 7.25e-02 3.26 0.64 1.00e+00 1.00e+00
3S100A4, HBEGF, SH3BGRL3
 248

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY 1.65e-05 79.36 13.63 4.41e-03 1.23e-01
3EREG, HBEGF, AREG
 13
GOBP_CELLULAR_RESPONSE_TO_ETHANOL 3.20e-05 61.17 10.83 7.04e-03 2.40e-01
3SOD2, SPI1, CYBB
 16
GOBP_POSITIVE_REGULATION_OF_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS 3.22e-04 103.49 9.64 3.49e-02 1.00e+00
2IL1B, PTGS2
 7
GOBP_POSITIVE_REGULATION_OF_FEVER_GENERATION 3.22e-04 103.49 9.64 3.49e-02 1.00e+00
2IL1B, PTGS2
 7
GOBP_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION 5.49e-04 74.10 7.33 5.02e-02 1.00e+00
2SLC11A1, PYCARD
 9
GOBP_FIBROBLAST_GROWTH_FACTOR_PRODUCTION 5.49e-04 74.10 7.33 5.02e-02 1.00e+00
2AIF1, PTGS2
 9
GOBP_POSITIVE_REGULATION_OF_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS 5.49e-04 74.10 7.33 5.02e-02 1.00e+00
2IL1B, PTGS2
 9
GOBP_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY 2.00e-05 29.33 7.30 4.99e-03 1.50e-01
4EREG, PLAUR, HBEGF, AREG
 41
GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION 1.13e-04 37.87 7.01 1.62e-02 8.45e-01
3NLRP3, FCER1G, CEBPB
 24
GOBP_FEVER_GENERATION 6.85e-04 64.86 6.55 5.55e-02 1.00e+00
2IL1B, PTGS2
 10
GOBP_POSITIVE_REGULATION_OF_HEAT_GENERATION 6.85e-04 64.86 6.55 5.55e-02 1.00e+00
2IL1B, PTGS2
 10
GOBP_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION 1.81e-04 31.85 5.95 2.37e-02 1.00e+00
3IL1B, C5AR1, PTGS2
 28
GOBP_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE 3.16e-06 17.38 5.92 1.13e-03 2.36e-02
6IL1B, NLRP3, SLC11A1, PYCARD, TNFSF13B, NFKBIZ
 104
GOBP_NAD_BIOSYNTHETIC_PROCESS 2.01e-04 30.63 5.74 2.59e-02 1.00e+00
3NAMPT, PTGS2, KYNU
 29
GOBP_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY 2.22e-04 29.50 5.54 2.68e-02 1.00e+00
3EREG, HBEGF, AREG
 30
GOBP_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION 2.16e-05 17.14 5.17 5.22e-03 1.62e-01
5IL1B, EREG, AIF1, TYROBP, PYCARD
 86
GOBP_INTERLEUKIN_4_PRODUCTION 2.96e-04 26.56 5.01 3.31e-02 1.00e+00
3NLRP3, FCER1G, CEBPB
 33
GOBP_REGULATION_OF_HEAT_GENERATION 1.18e-03 47.19 4.96 8.47e-02 1.00e+00
2IL1B, PTGS2
 13
GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 6.48e-08 10.53 4.82 7.55e-05 4.85e-04
11IL1B, SOD2, C5AR1, NLRP3, CXCL2, NFKBIA, CXCL3, TSPO, CEBPB, SLC11A1, PYCARD
 346
GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 1.35e-06 11.84 4.74 7.21e-04 1.01e-02
8IL1B, NLRP3, CXCL2, NFKBIA, CXCL3, TSPO, CEBPB, PYCARD
 209

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE29618_MONOCYTE_VS_PDC_UP 1.79e-25 50.77 27.00 8.72e-22 8.72e-22
21G0S2, LST1, SOD2, S100A4, C5AR1, NLRP3, AIF1, NCF2, CFP, HBEGF, SPI1, S100A11, IL1RN, CTSS, NAMPT, TSPO, TYROBP, TNFAIP2, IER3, SLC7A7, PILRA
 199
GSE10325_BCELL_VS_MYELOID_DN 4.34e-22 42.31 22.14 5.29e-19 2.12e-18
19PLAUR, LST1, S100A4, C5AR1, NLRP3, AIF1, NCF2, CFP, SRGN, HBEGF, IL1RN, COTL1, CEBPB, SLC11A1, AQP9, TNFAIP2, SLC7A7, LGALS2, PILRA
 200
GSE10325_LUPUS_BCELL_VS_LUPUS_MYELOID_DN 4.34e-22 42.31 22.14 5.29e-19 2.12e-18
19PLAUR, LST1, S100A4, C5AR1, NLRP3, AIF1, NCF2, CFP, S100A11, IL1RN, FCER1G, TSPO, TYROBP, CEBPB, SLC11A1, TNFAIP2, SLC7A7, S100A6, PILRA
 200
GSE29618_MONOCYTE_VS_MDC_UP 4.34e-22 42.31 22.14 5.29e-19 2.12e-18
19G0S2, SOD2, S100A4, C5AR1, NLRP3, CXCL2, AIF1, NCF2, NFKBIA, FCER1G, CTSS, NAMPT, TYROBP, CEBPB, SLC11A1, IER3, SLC7A7, CYBB, PILRA
 200
GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_DN 6.65e-19 35.18 18.04 6.48e-16 3.24e-15
17PLAUR, LST1, C5AR1, NLRP3, AIF1, NCF2, CFP, IL1RN, FCER1G, TYROBP, CEBPB, SLC11A1, TNFAIP2, KYNU, SLC7A7, CYBB, PILRA
 200
GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_DN 2.27e-17 31.95 16.17 1.58e-14 1.10e-13
16LST1, SOD2, C5AR1, AIF1, NCF2, CFP, SRGN, S100A11, FCER1G, NAMPT, PTGS2, TYROBP, AQP9, IER3, S100A6, PILRA
 200
GSE29618_MONOCYTE_VS_PDC_DAY7_FLU_VACCINE_UP 2.27e-17 31.95 16.17 1.58e-14 1.10e-13
16G0S2, LST1, SOD2, C5AR1, NLRP3, AIF1, NCF2, HBEGF, IL1RN, CTSS, NAMPT, CEBPB, TNFAIP2, IER3, SLC7A7, PILRA
 200
GSE9988_LOW_LPS_VS_VEHICLE_TREATED_MONOCYTE_UP 5.21e-16 29.58 14.74 3.11e-13 2.54e-12
15IL1B, EREG, G0S2, PLAUR, SOD2, NLRP3, CXCL2, NFKBIA, CXCL3, PTGS2, AQP9, TNFAIP2, IER3, AREG, NFKBIZ
 196
GSE29618_BCELL_VS_MONOCYTE_DN 7.03e-16 28.93 14.43 3.11e-13 3.43e-12
15STXBP2, PLAUR, SOD2, C5AR1, NLRP3, CXCL2, HBEGF, S100A11, CTSS, COTL1, PTGS2, PYCARD, SLC7A7, S100A6, PILRA
 200
GSE29618_PDC_VS_MDC_DN 7.03e-16 28.93 14.43 3.11e-13 3.43e-12
15LST1, S100A4, AIF1, NCF2, CFP, SPI1, IL1RN, NAMPT, COTL1, PTGS2, TNFAIP2, EMP3, LGALS2, STX11, PILRA
 200
GSE29618_MONOCYTE_VS_MDC_DAY7_FLU_VACCINE_UP 7.03e-16 28.93 14.43 3.11e-13 3.43e-12
15G0S2, SOD2, C5AR1, CXCL2, AIF1, NCF2, NFKBIA, CTSS, NAMPT, CEBPB, SLC11A1, IER3, SLC7A7, CYBB, PILRA
 200
GSE9988_LPS_VS_VEHICLE_TREATED_MONOCYTE_UP 1.50e-14 26.70 13.07 5.25e-12 7.30e-11
14IL1B, G0S2, PLAUR, SOD2, NLRP3, CXCL2, NFKBIA, CXCL3, PTGS2, AQP9, TNFAIP2, IER3, AREG, NFKBIZ
 196
GSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_UP 1.50e-14 26.70 13.07 5.25e-12 7.30e-11
14IL1B, EREG, G0S2, PLAUR, SOD2, NLRP3, CXCL2, NFKBIA, CXCL3, PTGS2, AQP9, IER3, AREG, NFKBIZ
 196
GSE22886_NAIVE_CD8_TCELL_VS_NEUTROPHIL_DN 1.61e-14 26.55 13.00 5.25e-12 7.83e-11
14IL1B, LST1, SOD2, C5AR1, FTH1, NCF2, SRGN, CTSS, NAMPT, PTGS2, TYROBP, CEBPB, AQP9, CYBB
 197
GSE9988_ANTI_TREM1_VS_LPS_MONOCYTE_DN 1.72e-14 26.41 12.93 5.25e-12 8.39e-11
14IL1B, G0S2, SOD2, NLRP3, CXCL2, NFKBIA, NAMPT, PTGS2, AQP9, TNFAIP2, IER3, NFKBIZ, STX11, PILRA
 198
GSE9988_ANTI_TREM1_VS_LOW_LPS_MONOCYTE_DN 1.72e-14 26.41 12.93 5.25e-12 8.39e-11
14IL1B, G0S2, SOD2, NLRP3, CXCL2, NFKBIA, CXCL3, PTGS2, AQP9, TNFAIP2, IER3, NFKBIZ, STX11, PILRA
 198
GSE9988_ANTI_TREM1_VS_ANTI_TREM1_AND_LPS_MONOCYTE_DN 3.65e-13 24.11 11.56 1.05e-10 1.78e-09
13IL1B, G0S2, PLAUR, SOD2, NLRP3, CXCL2, NFKBIA, CXCL3, PTGS2, AQP9, TNFAIP2, IER3, NFKBIZ
 195
GSE9988_LPS_VS_CTRL_TREATED_MONOCYTE_UP 3.89e-13 23.98 11.50 1.05e-10 1.90e-09
13IL1B, G0S2, PLAUR, SOD2, NLRP3, CXCL2, NFKBIA, CXCL3, PTGS2, AQP9, IER3, AREG, NFKBIZ
 196
GSE25123_CTRL_VS_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_UP 4.15e-13 23.85 11.44 1.06e-10 2.02e-09
13IL1B, EREG, PLAUR, NLRP3, CXCL2, CFP, IL1RN, NAMPT, CXCL3, AQP9, AREG, RILPL2, LGALS2
 197
GSE29618_PDC_VS_MDC_DAY7_FLU_VACCINE_DN 5.03e-13 23.47 11.26 1.17e-10 2.45e-09
13IL1B, LST1, S100A4, NLRP3, AIF1, NCF2, CFP, IL1RN, COTL1, CEBPB, TNFAIP2, EMP3, PILRA
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol TF Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
IL1B 1 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NLRP3 11 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Operates upstream in the signaling cascade
NFKBIA 17 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None This is I kappa B alpha, which interacts with NFkappaB. No DBD, and evidence indicates that it is not a TF.
SPI1 20 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CEBPB 31 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
PYCARD 38 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NFKBIZ 48 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PRAM1 51 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HCK 53 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Inhibits TP73-mediated transcription activation (PMID: 17535448)
MXD1 55 Yes Inferred motif Obligate heteromer In vivo/Misc source None All three MXD proteins have very similar sequences and should behave accordingly, making heterodimers with at least MAX (PMID:8521822).
ICAM1 62 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
PLEK 65 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None The DEP-domain is a winged helix-turn-helix protein domain, and thus it is related to ETS, RFX, and FOX domains. However, there is no evidence for DNA-binding activity and it has been shown to operate in G-protein signalling upstream of TFs
IRAK3 70 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
THAP2 80 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None None
ITGB2 81 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
TLR2 83 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Upstream of NFKB and not involved in DNA-binding
NR4A3 86 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
IL10 96 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RIPK2 98 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein activates NFKB through its kinase activity
FOSL2 106 Yes Known motif Monomer or homomultimer High-throughput in vitro None Also forms heterodimers.


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.


Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
T188_CATCCCAAGTTCACTG-1 Monocyte:CD16- 0.21 1139.56
Raw ScoresMonocyte:CD16-: 0.46, Monocyte:CD14+: 0.46, Monocyte:CD16+: 0.44, Monocyte: 0.44, Monocyte:leukotriene_D4: 0.44, Monocyte:anti-FcgRIIB: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, Monocyte:S._typhimurium_flagellin: 0.43, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, Pre-B_cell_CD34-: 0.43
T188_CATTGAGGTGTCCGTG-1 Monocyte:S._typhimurium_flagellin 0.19 1118.07
Raw ScoresMonocyte:CD16-: 0.47, Monocyte:CD14+: 0.46, Neutrophil:commensal_E._coli_MG1655: 0.45, Monocyte:S._typhimurium_flagellin: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Monocyte:CD16+: 0.45, Monocyte: 0.45, Monocyte:leukotriene_D4: 0.44, Monocyte:anti-FcgRIIB: 0.44, Neutrophil: 0.44
T188_ATGCCTCAGGAGCAAA-1 Monocyte:CD16- 0.19 1087.52
Raw ScoresMonocyte:CD16-: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.47, Monocyte:CD14+: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:leukotriene_D4: 0.46, Monocyte:anti-FcgRIIB: 0.46, Monocyte:CD16+: 0.46, Monocyte: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, Macrophage:monocyte-derived:M-CSF: 0.45
T188_GGGATGACAAATAAGC-1 Monocyte:CD16- 0.20 1016.53
Raw ScoresMonocyte:CD16-: 0.45, Monocyte:CD14+: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Monocyte:CD16+: 0.43, Neutrophil:commensal_E._coli_MG1655: 0.43, Monocyte: 0.43, Monocyte:leukotriene_D4: 0.43, Monocyte:anti-FcgRIIB: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, Monocyte:S._typhimurium_flagellin: 0.43
T188_AAAGGATAGGATTTGA-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.20 938.50
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.46, Monocyte:CD16-: 0.46, Monocyte:CD14+: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Monocyte:CD16+: 0.45, Monocyte:leukotriene_D4: 0.45, Monocyte:anti-FcgRIIB: 0.45, Monocyte: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, DC:monocyte-derived:AEC-conditioned: 0.43
T188_ATCGTCCCATTAAAGG-1 Monocyte:CD16- 0.20 923.61
Raw ScoresMonocyte:CD16-: 0.46, Monocyte:CD16+: 0.46, Monocyte:CD14+: 0.46, Monocyte:leukotriene_D4: 0.44, Monocyte:anti-FcgRIIB: 0.44, Monocyte: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Neutrophil:commensal_E._coli_MG1655: 0.43, Pre-B_cell_CD34-: 0.43
T188_CTGTATTTCTCGTGGG-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.19 904.20
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Monocyte:CD16-: 0.44, Monocyte:leukotriene_D4: 0.44, Monocyte: 0.44, Monocyte:anti-FcgRIIB: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.44, Macrophage:monocyte-derived:M-CSF: 0.43, Monocyte:CD14+: 0.43, Monocyte:CD16+: 0.43
T188_ACTTCGCGTCAAAGCG-1 Monocyte:S._typhimurium_flagellin 0.18 849.55
Raw ScoresMonocyte:CD16-: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48, Monocyte:CD14+: 0.47, Monocyte:CD16+: 0.47, Monocyte:anti-FcgRIIB: 0.47, Monocyte:leukotriene_D4: 0.47, Monocyte: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:S._typhimurium_flagellin: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46
T188_TTCACGCGTCCAGGTC-1 Monocyte:CD16+ 0.19 818.81
Raw ScoresMonocyte:CD16+: 0.48, Monocyte:CD16-: 0.47, Monocyte:CD14+: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:leukotriene_D4: 0.45, Monocyte: 0.45, Monocyte:anti-FcgRIIB: 0.45, DC:monocyte-derived:AEC-conditioned: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44
T19_CGCCAAGCATTAACCG.1 Monocyte:CD14+ 0.18 816.68
Raw ScoresMonocyte:CD16-: 0.44, Monocyte:CD14+: 0.43, Monocyte:CD16+: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Monocyte:anti-FcgRIIB: 0.41, Monocyte: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Monocyte:leukotriene_D4: 0.41, Pre-B_cell_CD34-: 0.4, Neutrophil:commensal_E._coli_MG1655: 0.4
T40_ACAGCCGGTCTAAACC.1 Monocyte:CD16- 0.17 767.15
Raw ScoresMonocyte:CD16-: 0.43, Monocyte:CD14+: 0.42, Monocyte:CD16+: 0.42, Monocyte:anti-FcgRIIB: 0.41, Monocyte:leukotriene_D4: 0.41, Monocyte: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41, Monocyte:S._typhimurium_flagellin: 0.41, Pre-B_cell_CD34-: 0.4
T19_CTCTGGTGTTTGGGCC.1 Monocyte:CD16- 0.22 761.49
Raw ScoresMonocyte:CD16-: 0.46, Monocyte:CD14+: 0.45, Monocyte:leukotriene_D4: 0.45, Monocyte:anti-FcgRIIB: 0.45, Monocyte: 0.45, Monocyte:CD16+: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, DC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43
T188_AGAGCAGGTTAAGAAC-1 Monocyte:CD16- 0.20 760.14
Raw ScoresMonocyte:CD16-: 0.48, Monocyte:CD14+: 0.48, Pre-B_cell_CD34-: 0.47, Monocyte:CD16+: 0.46, Monocyte:leukotriene_D4: 0.46, Monocyte: 0.46, Monocyte:anti-FcgRIIB: 0.46, HSC_-G-CSF: 0.45, Neutrophil:commensal_E._coli_MG1655: 0.45, Neutrophil: 0.45
T19_GCAATCATCAGATAAG.1 Monocyte:CD16- 0.19 735.36
Raw ScoresMonocyte:CD16-: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, Monocyte:CD14+: 0.43, Monocyte:CD16+: 0.42, Monocyte: 0.42, Monocyte:leukotriene_D4: 0.42, Monocyte:S._typhimurium_flagellin: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Monocyte:anti-FcgRIIB: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41
T175_CTCATCGCACCCTCTA-1 Monocyte:CD16- 0.19 727.19
Raw ScoresMonocyte:CD16-: 0.45, Monocyte:CD14+: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Monocyte:CD16+: 0.44, Monocyte:leukotriene_D4: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, Monocyte:anti-FcgRIIB: 0.43, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.43, Monocyte: 0.43, Monocyte:S._typhimurium_flagellin: 0.43
T19_ACGCCGAAGCGTTTAC.1 Monocyte:CD14+ 0.20 725.94
Raw ScoresMonocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Monocyte:CD16+: 0.42, Monocyte:leukotriene_D4: 0.4, Monocyte: 0.4, Monocyte:anti-FcgRIIB: 0.4, Neutrophil:commensal_E._coli_MG1655: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Pre-B_cell_CD34-: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.4
T19_AACCGCGGTGCCTGGT.1 Monocyte:CD16- 0.17 700.24
Raw ScoresMonocyte:CD16-: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:CD14+: 0.39, Monocyte:CD16+: 0.38, Monocyte:anti-FcgRIIB: 0.38, Monocyte: 0.38, Neutrophil:GM-CSF_IFNg: 0.38, Monocyte:S._typhimurium_flagellin: 0.38, Monocyte:leukotriene_D4: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg: 0.38
T214_GTGTTAGTCTTCTGGC-1 Monocyte:CD16- 0.12 669.50
Raw ScoresPre-B_cell_CD34-: 0.44, Monocyte:CD14+: 0.42, Monocyte:CD16-: 0.42, Monocyte:leukotriene_D4: 0.42, Monocyte: 0.41, Monocyte:CD16+: 0.41, Monocyte:anti-FcgRIIB: 0.41, HSC_-G-CSF: 0.41, Neutrophil:commensal_E._coli_MG1655: 0.4, T_cell:CD4+: 0.4
T188_GGAAGTGTCTGAACGT-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.22 646.45
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.47, Monocyte:CD16-: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, Monocyte:leukotriene_D4: 0.46, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, Monocyte: 0.46, Macrophage:monocyte-derived:M-CSF: 0.46, Monocyte:CD14+: 0.46, Monocyte:anti-FcgRIIB: 0.46, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.45
T19_AACTCCCCACGTCTCT.1 Monocyte:CD16+ 0.15 633.39
Raw ScoresMonocyte:CD14+: 0.38, Monocyte:CD16-: 0.38, Monocyte:CD16+: 0.37, Monocyte:anti-FcgRIIB: 0.36, Monocyte:leukotriene_D4: 0.36, Monocyte: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Macrophage:monocyte-derived:M-CSF: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35, Pre-B_cell_CD34-: 0.34
T19_TGGTTAGGTACACCGC.1 Monocyte:CD16- 0.18 632.13
Raw ScoresMonocyte:CD16-: 0.42, Monocyte:CD14+: 0.42, Monocyte:anti-FcgRIIB: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Monocyte:leukotriene_D4: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Monocyte: 0.41, Monocyte:CD16+: 0.41, DC:monocyte-derived:AEC-conditioned: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4
T27_GATGCTACATAGACTC.1 Monocyte:S._typhimurium_flagellin 0.17 628.06
Raw ScoresMonocyte:CD16-: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Monocyte:S._typhimurium_flagellin: 0.4, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.4, Monocyte:anti-FcgRIIB: 0.4, Monocyte:CD14+: 0.4, Monocyte:leukotriene_D4: 0.4, Monocyte: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Monocyte:CD16+: 0.39
T188_GAGAAATAGTCATCCA-1 Monocyte:CD16- 0.18 627.79
Raw ScoresMonocyte:CD16-: 0.44, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Monocyte: 0.44, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.44, Monocyte:anti-FcgRIIB: 0.43, Monocyte:CD14+: 0.43, Macrophage:monocyte-derived:M-CSF: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43, Monocyte:CD16+: 0.42
T27_TGTGGTAGTTATCACG.1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.17 625.85
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.39, Monocyte:CD16-: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:anti-FcgRIIB: 0.38, Monocyte:CD14+: 0.38, Neutrophil:commensal_E._coli_MG1655: 0.38, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.38, Monocyte: 0.38, Monocyte:CD16+: 0.38, Monocyte:leukotriene_D4: 0.38
T188_TCACGCTTCCTACGGG-1 DC:monocyte-derived:A._fumigatus_germ_tubes_6h 0.19 621.41
Raw ScoresDC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43, DC:monocyte-derived:antiCD40/VAF347: 0.42, Macrophage:monocyte-derived:S._aureus: 0.42, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.42, DC:monocyte-derived:Poly(IC): 0.42, DC:monocyte-derived:Schuler_treatment: 0.42, DC:monocyte-derived:LPS: 0.42, Macrophage:Alveolar:B._anthacis_spores: 0.41, DC:monocyte-derived:Galectin-1: 0.41
T19_TCTCATATCCCTAACC.1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.17 616.01
Raw ScoresMonocyte:CD16-: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:S._typhimurium_flagellin: 0.39, Monocyte:CD16+: 0.39, Monocyte:CD14+: 0.39, Monocyte:anti-FcgRIIB: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg: 0.38, Neutrophil:commensal_E._coli_MG1655: 0.38, Monocyte: 0.38, Monocyte:leukotriene_D4: 0.38
T200_CTCAGGGAGAAGTCAT-1 Monocyte:CD16+ 0.21 610.38
Raw ScoresMonocyte:CD16+: 0.49, Monocyte:CD14+: 0.48, Monocyte:CD16-: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, Monocyte: 0.46, Monocyte:leukotriene_D4: 0.45, Monocyte:anti-FcgRIIB: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Pre-B_cell_CD34-: 0.44, Neutrophil:GM-CSF_IFNg: 0.43
T40_GTTCATTAGTAAGTAC.1 Monocyte:CD16- 0.16 603.92
Raw ScoresMonocyte:CD16-: 0.42, Monocyte:CD14+: 0.41, Monocyte:CD16+: 0.41, Monocyte:leukotriene_D4: 0.4, Monocyte: 0.4, Pre-B_cell_CD34-: 0.4, Monocyte:anti-FcgRIIB: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Neutrophil:commensal_E._coli_MG1655: 0.39, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39
T200_TCGCTCAAGCGATGAC-1 Monocyte:CD16+ 0.19 599.48
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Monocyte:leukotriene_D4: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.48, Macrophage:monocyte-derived:M-CSF: 0.48, Monocyte:anti-FcgRIIB: 0.47, Monocyte: 0.47, DC:monocyte-derived:AEC-conditioned: 0.47, Monocyte:CD16-: 0.47, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.46, DC:monocyte-derived:anti-DC-SIGN_2h: 0.46
T27_ACACTGATCTGATTCT.1 Monocyte:anti-FcgRIIB 0.16 594.30
Raw ScoresMonocyte:S._typhimurium_flagellin: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.4, Monocyte:anti-FcgRIIB: 0.39, Monocyte:CD16-: 0.39, Monocyte: 0.38, Macrophage:monocyte-derived:S._aureus: 0.38, Monocyte:leukotriene_D4: 0.38, DC:monocyte-derived:Schuler_treatment: 0.38, DC:monocyte-derived:antiCD40/VAF347: 0.38
T188_AAGTCGTGTCCGGTCA-1 Monocyte:CD16+ 0.13 589.03
Raw ScoresMonocyte:CD16-: 0.36, Monocyte:CD14+: 0.35, Monocyte:leukotriene_D4: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg: 0.35, Monocyte: 0.35, Macrophage:monocyte-derived:M-CSF: 0.35, Monocyte:anti-FcgRIIB: 0.35, Monocyte:CD16+: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.34, DC:monocyte-derived:anti-DC-SIGN_2h: 0.34
T188_CAGCAATCACAGAAGC-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.09 583.88
Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.38, Macrophage:monocyte-derived:IFNa: 0.37, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.36, Macrophage:monocyte-derived:S._aureus: 0.35, Macrophage:monocyte-derived: 0.35, DC:monocyte-derived:LPS: 0.35, DC:monocyte-derived:Poly(IC): 0.35, DC:monocyte-derived:Galectin-1: 0.35, DC:monocyte-derived:mature: 0.35
T200_TAGAGTCCAGAGAGGG-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.22 572.67
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45, Monocyte:anti-FcgRIIB: 0.45, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, DC:monocyte-derived:LPS: 0.44, Macrophage:monocyte-derived:S._aureus: 0.44, Monocyte:leukotriene_D4: 0.44, Macrophage:monocyte-derived:IFNa: 0.44, Macrophage:Alveolar:B._anthacis_spores: 0.44, DC:monocyte-derived:AEC-conditioned: 0.44
T188_TCCGTGTCATACACCA-1 Monocyte:CD16- 0.17 568.11
Raw ScoresMonocyte:CD16-: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Monocyte:CD14+: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Monocyte:leukotriene_D4: 0.39, Monocyte:anti-FcgRIIB: 0.39, Monocyte: 0.39, Monocyte:CD16+: 0.39, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.39, Macrophage:monocyte-derived:M-CSF: 0.39
T34_CTGTGCTCAAGAAAGG.1 Monocyte:CD16- 0.16 551.37
Raw ScoresMonocyte:CD16-: 0.38, Monocyte:CD14+: 0.38, Monocyte:CD16+: 0.37, Pre-B_cell_CD34-: 0.36, Neutrophil:commensal_E._coli_MG1655: 0.35, Monocyte:S._typhimurium_flagellin: 0.35, Monocyte: 0.35, Monocyte:anti-FcgRIIB: 0.35, Neutrophil: 0.35, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.35
T19_GACGCGTAGAAGGTTT.1 Neutrophil:commensal_E._coli_MG1655 0.16 548.76
Raw ScoresMonocyte:CD16-: 0.38, Monocyte:CD14+: 0.37, Monocyte:CD16+: 0.37, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.36, Monocyte:leukotriene_D4: 0.36, Monocyte: 0.36, Neutrophil:commensal_E._coli_MG1655: 0.36, Monocyte:anti-FcgRIIB: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, Pre-B_cell_CD34-: 0.35
T188_TGTCCACGTAGTCTGT-1 Monocyte:CD16- 0.18 542.33
Raw ScoresMonocyte:CD16-: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:CD14+: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg: 0.46, Monocyte:CD16+: 0.45, Monocyte:anti-FcgRIIB: 0.45, Monocyte:leukotriene_D4: 0.45, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.45, Monocyte: 0.45, Macrophage:monocyte-derived:M-CSF: 0.44
T188_GTTTGGAGTAGGTACG-1 Monocyte:CD16- 0.17 541.83
Raw ScoresMonocyte:leukotriene_D4: 0.45, Monocyte:CD16-: 0.45, Monocyte:CD14+: 0.45, Monocyte: 0.45, Monocyte:anti-FcgRIIB: 0.44, Monocyte:CD16+: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Neutrophil:commensal_E._coli_MG1655: 0.44, Pre-B_cell_CD34-: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.43
T200_TTCCGTGTCCCGAGAC-1 Monocyte:CD16+ 0.17 536.32
Raw ScoresMonocyte:CD16+: 0.43, Monocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg: 0.42, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.41, Monocyte:anti-FcgRIIB: 0.41, Monocyte: 0.41, Monocyte:leukotriene_D4: 0.41, Macrophage:monocyte-derived:M-CSF: 0.4, Neutrophil:GM-CSF_IFNg: 0.4
T200_AGGGTCCCAGTACTAC-1 Monocyte:CD16+ 0.18 524.06
Raw ScoresMonocyte:CD16+: 0.49, Monocyte:CD16-: 0.49, Monocyte:CD14+: 0.49, Macrophage:monocyte-derived:M-CSF/IFNg: 0.48, Monocyte: 0.47, Monocyte:anti-FcgRIIB: 0.47, Monocyte:leukotriene_D4: 0.46, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Pre-B_cell_CD34-: 0.45, DC:monocyte-derived:AEC-conditioned: 0.45
T19_CTCGAAACATGGTCAT.1 Monocyte:CD14+ 0.20 523.83
Raw ScoresMonocyte:CD16-: 0.47, Monocyte:CD14+: 0.46, Monocyte:leukotriene_D4: 0.46, Monocyte:CD16+: 0.45, Monocyte: 0.45, Monocyte:anti-FcgRIIB: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Macrophage:monocyte-derived:M-CSF: 0.44, DC:monocyte-derived:AEC-conditioned: 0.43, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.43
T19_CTACCCACATATACCG.1 Monocyte:CD16- 0.18 511.86
Raw ScoresMonocyte:CD16-: 0.41, Monocyte:CD14+: 0.41, Monocyte:CD16+: 0.4, Monocyte:anti-FcgRIIB: 0.39, Monocyte: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:leukotriene_D4: 0.39, Pre-B_cell_CD34-: 0.39, Neutrophil: 0.38
T19_GCTGGGTCATACTACG.1 Monocyte:CD14+ 0.18 511.10
Raw ScoresMonocyte:CD16-: 0.43, Monocyte:CD14+: 0.42, Monocyte:CD16+: 0.42, Monocyte:leukotriene_D4: 0.41, Monocyte: 0.41, Monocyte:anti-FcgRIIB: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Pre-B_cell_CD34-: 0.39
T27_ACAGCCGGTAAACCTC.1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.16 509.30
Raw ScoresMonocyte:CD16-: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Monocyte:anti-FcgRIIB: 0.39, Monocyte:leukotriene_D4: 0.38, Monocyte:CD14+: 0.38, Monocyte: 0.38, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.38, Macrophage:monocyte-derived:M-CSF/IFNg: 0.38, Monocyte:CD16+: 0.38, Macrophage:monocyte-derived:M-CSF: 0.38
T19_GGCAATTAGAATAGGG.1 Monocyte 0.16 508.79
Raw ScoresMonocyte:CD16-: 0.41, Monocyte:CD14+: 0.4, Monocyte:anti-FcgRIIB: 0.4, Monocyte:leukotriene_D4: 0.4, Monocyte: 0.4, Macrophage:monocyte-derived:M-CSF: 0.39, Monocyte:CD16+: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.39, Macrophage:monocyte-derived:M-CSF/IFNg: 0.39, Monocyte:S._typhimurium_flagellin: 0.38
T40_AGGGAGTTCCCGGATG.1 Macrophage:monocyte-derived:M-CSF/IFNg 0.16 508.39
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.44, Macrophage:monocyte-derived:M-CSF/IFNg: 0.44, Monocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Monocyte:anti-FcgRIIB: 0.43, Monocyte: 0.43, Monocyte:CD16+: 0.43, Monocyte:leukotriene_D4: 0.42, Pre-B_cell_CD34-: 0.41, Macrophage:monocyte-derived:M-CSF/Pam3Cys: 0.41
T19_ACGGAGACAATCTGCA.1 Monocyte:CD16- 0.17 505.36
Raw ScoresMonocyte:CD16-: 0.42, Monocyte:CD14+: 0.41, Monocyte:leukotriene_D4: 0.41, Monocyte: 0.41, Monocyte:CD16+: 0.4, Monocyte:anti-FcgRIIB: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg: 0.4, Macrophage:monocyte-derived:M-CSF: 0.4, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Pre-B_cell_CD34-: 0.39
T200_GGGAGATGTCTCGACG-1 Macrophage:monocyte-derived:M-CSF/IFNg 0.22 504.57
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.48, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.46, Monocyte:leukotriene_D4: 0.46, Monocyte:CD16-: 0.46, Monocyte:anti-FcgRIIB: 0.46, DC:monocyte-derived:AEC-conditioned: 0.46, Macrophage:monocyte-derived:IFNa: 0.46, DC:monocyte-derived:LPS: 0.46, Monocyte:CD14+: 0.46, Macrophage:monocyte-derived:S._aureus: 0.46
T200_GCGGAAAAGCATAGGC-1 Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys 0.18 502.14
Raw ScoresMacrophage:monocyte-derived:M-CSF/IFNg: 0.47, Monocyte:CD16-: 0.47, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.47, Monocyte:CD14+: 0.46, Monocyte:anti-FcgRIIB: 0.46, Monocyte:leukotriene_D4: 0.46, Monocyte: 0.46, Monocyte:CD16+: 0.46, DC:monocyte-derived:AEC-conditioned: 0.45, Macrophage:monocyte-derived:M-CSF: 0.45
T19_TCGGGACCAAAGTGCG.1 Monocyte:CD16+ 0.17 497.74
Raw ScoresMonocyte:CD16-: 0.43, Monocyte:CD14+: 0.43, Monocyte:CD16+: 0.42, Monocyte:leukotriene_D4: 0.41, Monocyte: 0.41, Monocyte:anti-FcgRIIB: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg: 0.41, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.4, Pre-B_cell_CD34-: 0.4, Macrophage:monocyte-derived:M-CSF: 0.39


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.88e-06
Mean rank of genes in gene set: 2035.53
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IL1B 0.0135789 1 GTEx DepMap Descartes 14.75 2110.19
IL10 0.0033251 96 GTEx DepMap Descartes 0.82 82.36
VEGFA 0.0026950 138 GTEx DepMap Descartes 0.68 13.60
TNF 0.0025188 165 GTEx DepMap Descartes 1.38 163.91
CD36 0.0017755 281 GTEx DepMap Descartes 1.00 40.91
CD14 0.0015131 353 GTEx DepMap Descartes 6.70 893.07
TGFB1 0.0011339 507 GTEx DepMap Descartes 0.90 69.83
HIF1A 0.0011163 514 GTEx DepMap Descartes 0.98 58.15
TNFRSF10B 0.0008446 664 GTEx DepMap Descartes 0.24 12.02
CD84 0.0004171 1163 GTEx DepMap Descartes 0.77 18.80
CD274 0.0000977 2234 GTEx DepMap Descartes 0.04 2.59
NOS2 0.0000296 2825 GTEx DepMap Descartes 0.00 0.00
ARG1 -0.0000201 3642 GTEx DepMap Descartes 0.00 0.85
STAT3 -0.0001279 6792 GTEx DepMap Descartes 0.72 28.31
ARG2 -0.0003392 11158 GTEx DepMap Descartes 0.05 4.48


PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.47e-05
Mean rank of genes in gene set: 2674.25
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IL1B 0.0135789 1 GTEx DepMap Descartes 14.75 2110.19
PTGS2 0.0062290 28 GTEx DepMap Descartes 1.40 77.19
CD36 0.0017755 281 GTEx DepMap Descartes 1.00 40.91
STAT1 0.0011468 501 GTEx DepMap Descartes 1.61 67.93
TGFB1 0.0011339 507 GTEx DepMap Descartes 0.90 69.83
IRF1 0.0011280 509 GTEx DepMap Descartes 1.14 47.17
HIF1A 0.0011163 514 GTEx DepMap Descartes 0.98 58.15
STAT6 0.0009964 576 GTEx DepMap Descartes 0.16 7.93
TNFRSF10B 0.0008446 664 GTEx DepMap Descartes 0.24 12.02
ANXA1 0.0006606 829 GTEx DepMap Descartes 2.02 196.37
CD84 0.0004171 1163 GTEx DepMap Descartes 0.77 18.80
ARG1 -0.0000201 3642 GTEx DepMap Descartes 0.00 0.85
SLC27A2 -0.0000660 4924 GTEx DepMap Descartes 0.01 0.51
STAT3 -0.0001279 6792 GTEx DepMap Descartes 0.72 28.31
CSF1 -0.0002997 10699 GTEx DepMap Descartes 0.08 3.95
ARG2 -0.0003392 11158 GTEx DepMap Descartes 0.05 4.48


M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.22e-05
Mean rank of genes in gene set: 1982.55
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
IL1B 0.0135789 1 GTEx DepMap Descartes 14.75 2110.19
ITGAX 0.0045375 56 GTEx DepMap Descartes 0.65 30.58
TNF 0.0025188 165 GTEx DepMap Descartes 1.38 163.91
CD14 0.0015131 353 GTEx DepMap Descartes 6.70 893.07
TLR4 0.0014729 369 GTEx DepMap Descartes 0.33 5.76
CXCL16 0.0011924 482 GTEx DepMap Descartes 1.63 154.73
CD80 0.0008575 653 GTEx DepMap Descartes 0.11 7.20
IL18 0.0003987 1199 GTEx DepMap Descartes 1.18 130.64
CCL2 0.0000510 2598 GTEx DepMap Descartes 2.03 464.25
IL33 -0.0000903 5659 GTEx DepMap Descartes 0.00 0.27
CCL5 -0.0002722 10273 GTEx DepMap Descartes 0.51 69.87




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9882.5
Median rank of genes in gene set: 10960
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LYN 0.0037594 76 GTEx DepMap Descartes 0.98 36.51
AP1S2 0.0024114 184 GTEx DepMap Descartes 1.48 95.51
GLRX 0.0021325 226 GTEx DepMap Descartes 1.77 106.58
GCH1 0.0013752 403 GTEx DepMap Descartes 0.30 22.28
NFIL3 0.0012106 464 GTEx DepMap Descartes 0.46 55.31
ATP6V1B2 0.0010042 574 GTEx DepMap Descartes 0.99 29.91
UCP2 0.0009244 608 GTEx DepMap Descartes 2.05 205.45
HK2 0.0007692 722 GTEx DepMap Descartes 0.24 10.03
DAPK1 0.0003357 1336 GTEx DepMap Descartes 0.29 8.99
CELF2 0.0003213 1386 GTEx DepMap Descartes 0.62 16.61
RBBP8 0.0001766 1827 GTEx DepMap Descartes 0.12 6.87
FAM107B 0.0001597 1906 GTEx DepMap Descartes 0.51 30.18
TIAM1 0.0000860 2325 GTEx DepMap Descartes 0.10 3.10
AGTPBP1 0.0000465 2648 GTEx DepMap Descartes 0.10 5.83
PPP2R3C 0.0000423 2691 GTEx DepMap Descartes 0.30 35.71
ST3GAL6 0.0000183 2935 GTEx DepMap Descartes 0.28 16.33
INO80C -0.0000191 3613 GTEx DepMap Descartes 0.16 10.42
ANP32A -0.0000333 3975 GTEx DepMap Descartes 0.83 44.42
IRS2 -0.0000491 4440 GTEx DepMap Descartes 0.53 13.78
SETD7 -0.0000526 4524 GTEx DepMap Descartes 0.09 2.55
EML6 -0.0000586 4688 GTEx DepMap Descartes 0.01 0.15
POPDC3 -0.0000589 4695 GTEx DepMap Descartes 0.01 0.92
BEND4 -0.0000638 4852 GTEx DepMap Descartes 0.00 0.16
MYRIP -0.0000656 4907 GTEx DepMap Descartes 0.01 0.35
FAM167A -0.0000705 5053 GTEx DepMap Descartes 0.01 0.44
GLDC -0.0000712 5071 GTEx DepMap Descartes 0.00 0.11
DIABLO -0.0000741 5161 GTEx DepMap Descartes 0.03 1.77
CHML -0.0000780 5285 GTEx DepMap Descartes 0.14 3.76
MYO5A -0.0000803 5360 GTEx DepMap Descartes 0.20 3.05
PHPT1 -0.0000828 5432 GTEx DepMap Descartes 1.75 277.44


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.86e-10
Mean rank of genes in gene set: 5225.36
Median rank of genes in gene set: 4651
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ARPC1B 0.0039328 71 GTEx DepMap Descartes 4.17 501.84
TIMP1 0.0034969 87 GTEx DepMap Descartes 4.89 1249.52
GRN 0.0031223 103 GTEx DepMap Descartes 7.42 701.66
IFITM2 0.0029599 118 GTEx DepMap Descartes 2.14 588.21
IFITM3 0.0029424 120 GTEx DepMap Descartes 6.67 2000.94
ANXA5 0.0027261 134 GTEx DepMap Descartes 2.50 309.71
NOTCH2 0.0027122 136 GTEx DepMap Descartes 0.24 4.83
PLSCR1 0.0026917 139 GTEx DepMap Descartes 1.32 142.46
CMTM6 0.0026707 143 GTEx DepMap Descartes 1.55 102.12
RAB31 0.0025701 152 GTEx DepMap Descartes 0.72 40.37
LITAF 0.0025335 162 GTEx DepMap Descartes 3.23 264.88
FLNA 0.0025043 170 GTEx DepMap Descartes 0.80 23.62
NPC2 0.0022519 209 GTEx DepMap Descartes 8.37 1263.12
DUSP6 0.0022176 213 GTEx DepMap Descartes 0.48 34.63
CD44 0.0022144 215 GTEx DepMap Descartes 2.15 99.93
INSIG1 0.0021927 218 GTEx DepMap Descartes 0.97 77.49
ZFP36L1 0.0021520 222 GTEx DepMap Descartes 3.27 232.22
HNMT 0.0020702 232 GTEx DepMap Descartes 0.93 63.95
THBS1 0.0020609 234 GTEx DepMap Descartes 0.27 9.42
MOB1A 0.0019850 247 GTEx DepMap Descartes 1.18 52.49
PLXDC2 0.0019498 254 GTEx DepMap Descartes 0.59 11.21
SH3BGRL 0.0018703 266 GTEx DepMap Descartes 2.04 248.01
LGALS1 0.0018419 269 GTEx DepMap Descartes 11.80 4095.79
DSE 0.0018413 270 GTEx DepMap Descartes 0.45 10.43
KLF4 0.0018375 271 GTEx DepMap Descartes 1.64 123.80
IL13RA1 0.0018351 272 GTEx DepMap Descartes 0.50 26.61
VIM 0.0017223 295 GTEx DepMap Descartes 13.49 1074.93
PYGL 0.0017030 306 GTEx DepMap Descartes 0.17 13.24
B2M 0.0014841 362 GTEx DepMap Descartes 97.62 8340.91
RNH1 0.0014781 365 GTEx DepMap Descartes 1.34 84.07


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.95e-01
Mean rank of genes in gene set: 6581.83
Median rank of genes in gene set: 6680.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LDLR 0.0013873 402 GTEx DepMap Descartes 0.11 4.47
PAPSS2 0.0009483 600 GTEx DepMap Descartes 0.17 9.54
SH3BP5 0.0004880 1041 GTEx DepMap Descartes 0.37 21.30
ERN1 0.0004441 1123 GTEx DepMap Descartes 0.30 7.80
POR 0.0002704 1517 GTEx DepMap Descartes 0.38 32.75
FDX1 0.0001047 2194 GTEx DepMap Descartes 0.56 38.41
SH3PXD2B 0.0000878 2306 GTEx DepMap Descartes 0.06 1.33
NPC1 0.0000013 3163 GTEx DepMap Descartes 0.10 4.07
FDXR -0.0000380 4098 GTEx DepMap Descartes 0.08 7.72
HMGCR -0.0000433 4271 GTEx DepMap Descartes 0.11 4.68
FREM2 -0.0000493 4448 GTEx DepMap Descartes 0.00 0.01
STAR -0.0000556 4598 GTEx DepMap Descartes 0.00 0.12
BAIAP2L1 -0.0000696 5025 GTEx DepMap Descartes 0.00 0.21
FRMD5 -0.0000748 5177 GTEx DepMap Descartes 0.02 0.58
INHA -0.0000751 5184 GTEx DepMap Descartes 0.00 0.08
GRAMD1B -0.0000771 5248 GTEx DepMap Descartes 0.04 0.72
SCAP -0.0000778 5277 GTEx DepMap Descartes 0.11 5.20
SGCZ -0.0000947 5779 GTEx DepMap Descartes 0.00 0.07
SLC1A2 -0.0001548 7582 GTEx DepMap Descartes 0.06 0.95
PDE10A -0.0001605 7759 GTEx DepMap Descartes 0.02 0.30
DNER -0.0001851 8431 GTEx DepMap Descartes 0.04 1.68
CLU -0.0002039 8916 GTEx DepMap Descartes 0.34 17.13
HMGCS1 -0.0002163 9180 GTEx DepMap Descartes 0.15 6.06
SCARB1 -0.0002205 9280 GTEx DepMap Descartes 0.16 5.77
DHCR24 -0.0002252 9363 GTEx DepMap Descartes 0.03 1.29
IGF1R -0.0002287 9448 GTEx DepMap Descartes 0.09 1.18
APOC1 -0.0002292 9461 GTEx DepMap Descartes 37.19 10647.92
SLC16A9 -0.0002305 9483 GTEx DepMap Descartes 0.02 0.74
DHCR7 -0.0002469 9824 GTEx DepMap Descartes 0.05 3.45
CYB5B -0.0002506 9905 GTEx DepMap Descartes 0.23 10.54


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10170.12
Median rank of genes in gene set: 11428
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RPH3A -0.0000366 4054 GTEx DepMap Descartes 0.02 0.91
GREM1 -0.0000498 4465 GTEx DepMap Descartes 0.01 0.14
EPHA6 -0.0000768 5238 GTEx DepMap Descartes 0.00 0.25
ANKFN1 -0.0000776 5270 GTEx DepMap Descartes 0.01 0.23
SLC44A5 -0.0000899 5643 GTEx DepMap Descartes 0.02 0.73
RYR2 -0.0001500 7449 GTEx DepMap Descartes 0.02 0.20
ALK -0.0001693 7978 GTEx DepMap Descartes 0.02 0.46
FAT3 -0.0001820 8340 GTEx DepMap Descartes 0.03 0.31
EYA1 -0.0001840 8397 GTEx DepMap Descartes 0.02 0.53
KCNB2 -0.0001935 8662 GTEx DepMap Descartes 0.02 0.64
HS3ST5 -0.0001959 8722 GTEx DepMap Descartes 0.01 0.32
PTCHD1 -0.0001976 8761 GTEx DepMap Descartes 0.03 0.50
TMEM132C -0.0001981 8777 GTEx DepMap Descartes 0.02 0.58
EYA4 -0.0002025 8885 GTEx DepMap Descartes 0.02 0.40
CNKSR2 -0.0002296 9466 GTEx DepMap Descartes 0.03 0.38
SLC6A2 -0.0002585 10044 GTEx DepMap Descartes 0.04 1.71
SYNPO2 -0.0002589 10047 GTEx DepMap Descartes 0.11 1.14
NTRK1 -0.0002755 10316 GTEx DepMap Descartes 0.10 4.05
PLXNA4 -0.0002935 10622 GTEx DepMap Descartes 0.03 0.32
TMEFF2 -0.0003195 10950 GTEx DepMap Descartes 0.05 2.12
RGMB -0.0003658 11428 GTEx DepMap Descartes 0.09 3.54
REEP1 -0.0003976 11622 GTEx DepMap Descartes 0.05 1.97
RBFOX1 -0.0004095 11713 GTEx DepMap Descartes 0.04 1.80
NPY -0.0004350 11828 GTEx DepMap Descartes 3.05 709.56
IL7 -0.0004519 11906 GTEx DepMap Descartes 0.07 7.14
CNTFR -0.0004538 11918 GTEx DepMap Descartes 0.13 10.31
MAB21L2 -0.0004759 12013 GTEx DepMap Descartes 0.16 8.37
GAL -0.0004773 12018 GTEx DepMap Descartes 0.24 53.06
TUBB2A -0.0004871 12055 GTEx DepMap Descartes 0.70 57.91
MAB21L1 -0.0004945 12076 GTEx DepMap Descartes 0.16 8.38


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 8447.74
Median rank of genes in gene set: 9622.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMEM88 0.0006525 835 GTEx DepMap Descartes 0.15 42.04
F8 0.0001629 1894 GTEx DepMap Descartes 0.01 0.32
NR5A2 0.0000758 2393 GTEx DepMap Descartes 0.00 0.01
RASIP1 0.0000438 2676 GTEx DepMap Descartes 0.02 1.04
ESM1 -0.0000397 4164 GTEx DepMap Descartes 0.05 1.39
MYRIP -0.0000656 4907 GTEx DepMap Descartes 0.01 0.35
CLDN5 -0.0000886 5607 GTEx DepMap Descartes 0.03 2.18
IRX3 -0.0001044 6058 GTEx DepMap Descartes 0.01 1.04
SHANK3 -0.0001145 6363 GTEx DepMap Descartes 0.01 0.19
EHD3 -0.0001151 6383 GTEx DepMap Descartes 0.00 0.09
ROBO4 -0.0001153 6395 GTEx DepMap Descartes 0.02 0.51
CYP26B1 -0.0001154 6399 GTEx DepMap Descartes 0.02 0.45
NPR1 -0.0001343 6999 GTEx DepMap Descartes 0.00 0.07
FLT4 -0.0001368 7065 GTEx DepMap Descartes 0.00 0.11
CHRM3 -0.0001524 7542 GTEx DepMap Descartes 0.07 1.70
CRHBP -0.0001878 8502 GTEx DepMap Descartes 0.07 7.51
KANK3 -0.0001973 8753 GTEx DepMap Descartes 0.00 0.09
CDH5 -0.0002177 9217 GTEx DepMap Descartes 0.03 0.78
NOTCH4 -0.0002327 9531 GTEx DepMap Descartes 0.06 1.36
TIE1 -0.0002412 9714 GTEx DepMap Descartes 0.01 0.09
SHE -0.0002444 9767 GTEx DepMap Descartes 0.01 0.11
CDH13 -0.0002468 9822 GTEx DepMap Descartes 0.01 0.11
KDR -0.0002497 9885 GTEx DepMap Descartes 0.02 0.25
TEK -0.0002497 9886 GTEx DepMap Descartes 0.01 0.12
CALCRL -0.0002639 10132 GTEx DepMap Descartes 0.02 0.72
GALNT15 -0.0002770 10349 GTEx DepMap Descartes 0.00 NA
BTNL9 -0.0002837 10469 GTEx DepMap Descartes 0.00 0.15
MMRN2 -0.0003594 11359 GTEx DepMap Descartes 0.01 0.32
PODXL -0.0003629 11402 GTEx DepMap Descartes 0.03 0.44
CEACAM1 -0.0003709 11460 GTEx DepMap Descartes 0.01 0.69


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.58e-01
Mean rank of genes in gene set: 6217.61
Median rank of genes in gene set: 6115.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GLI2 0.0000825 2352 GTEx DepMap Descartes 0.00 0.04
IGFBP3 0.0000671 2466 GTEx DepMap Descartes 0.05 2.44
ABCC9 0.0000545 2568 GTEx DepMap Descartes 0.00 0.03
CLDN11 -0.0000169 3566 GTEx DepMap Descartes 0.01 0.63
LRRC17 -0.0000234 3715 GTEx DepMap Descartes 0.01 0.91
ABCA6 -0.0000305 3896 GTEx DepMap Descartes 0.05 0.93
PAMR1 -0.0000316 3921 GTEx DepMap Descartes 0.02 1.11
LAMC3 -0.0000342 3998 GTEx DepMap Descartes 0.00 0.00
SFRP2 -0.0000353 4025 GTEx DepMap Descartes 0.00 0.00
ADAMTSL3 -0.0000417 4225 GTEx DepMap Descartes 0.00 0.09
COL27A1 -0.0000460 4346 GTEx DepMap Descartes 0.02 0.37
FREM1 -0.0000556 4603 GTEx DepMap Descartes 0.00 0.08
LOX -0.0000596 4719 GTEx DepMap Descartes 0.02 0.76
ITGA11 -0.0000711 5065 GTEx DepMap Descartes 0.00 0.02
EDNRA -0.0000716 5087 GTEx DepMap Descartes 0.01 0.30
C7 -0.0000743 5171 GTEx DepMap Descartes 0.03 0.43
PCDH18 -0.0000875 5578 GTEx DepMap Descartes 0.00 0.11
CCDC80 -0.0000895 5633 GTEx DepMap Descartes 0.05 0.85
ACTA2 -0.0000897 5639 GTEx DepMap Descartes 0.07 10.14
COL12A1 -0.0000986 5881 GTEx DepMap Descartes 0.03 0.41
LUM -0.0001043 6053 GTEx DepMap Descartes 0.39 20.25
PRRX1 -0.0001055 6088 GTEx DepMap Descartes 0.01 0.27
SCARA5 -0.0001073 6143 GTEx DepMap Descartes 0.00 0.00
RSPO3 -0.0001125 6299 GTEx DepMap Descartes 0.00 NA
BICC1 -0.0001135 6327 GTEx DepMap Descartes 0.01 0.32
POSTN -0.0001167 6433 GTEx DepMap Descartes 0.02 1.17
COL6A3 -0.0001223 6614 GTEx DepMap Descartes 0.07 1.09
ADAMTS2 -0.0001232 6655 GTEx DepMap Descartes 0.02 0.56
DCN -0.0001302 6876 GTEx DepMap Descartes 0.51 9.68
COL3A1 -0.0001379 7099 GTEx DepMap Descartes 0.18 6.10


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 7824.95
Median rank of genes in gene set: 8171
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GCH1 0.0013752 403 GTEx DepMap Descartes 0.30 22.28
TIAM1 0.0000860 2325 GTEx DepMap Descartes 0.10 3.10
ST18 0.0000451 2657 GTEx DepMap Descartes 0.02 0.69
PENK -0.0000463 4354 GTEx DepMap Descartes 0.00 0.58
EML6 -0.0000586 4688 GTEx DepMap Descartes 0.01 0.15
SORCS3 -0.0000681 4983 GTEx DepMap Descartes 0.00 0.19
LAMA3 -0.0000781 5287 GTEx DepMap Descartes 0.00 0.02
DGKK -0.0000797 5341 GTEx DepMap Descartes 0.01 0.26
CNTN3 -0.0000800 5351 GTEx DepMap Descartes 0.00 0.13
TBX20 -0.0000812 5386 GTEx DepMap Descartes 0.00 0.00
CDH18 -0.0000889 5617 GTEx DepMap Descartes 0.00 0.10
AGBL4 -0.0001014 5965 GTEx DepMap Descartes 0.00 0.20
GRM7 -0.0001042 6051 GTEx DepMap Descartes 0.00 0.05
CDH12 -0.0001277 6784 GTEx DepMap Descartes 0.00 0.02
TENM1 -0.0001400 7157 GTEx DepMap Descartes 0.01 NA
SPOCK3 -0.0001500 7453 GTEx DepMap Descartes 0.01 0.25
PACRG -0.0001502 7459 GTEx DepMap Descartes 0.01 1.20
SLC24A2 -0.0001527 7543 GTEx DepMap Descartes 0.00 0.00
GALNTL6 -0.0001646 7870 GTEx DepMap Descartes 0.00 0.11
PCSK2 -0.0001865 8472 GTEx DepMap Descartes 0.01 0.13
GRID2 -0.0001975 8760 GTEx DepMap Descartes 0.02 0.26
SLC35F3 -0.0002015 8857 GTEx DepMap Descartes 0.01 0.42
UNC80 -0.0002020 8869 GTEx DepMap Descartes 0.03 0.43
SLC18A1 -0.0002161 9175 GTEx DepMap Descartes 0.03 1.37
KSR2 -0.0002168 9194 GTEx DepMap Descartes 0.01 0.08
CCSER1 -0.0002180 9222 GTEx DepMap Descartes 0.03 NA
FGF14 -0.0002359 9610 GTEx DepMap Descartes 0.03 0.38
ROBO1 -0.0002403 9699 GTEx DepMap Descartes 0.06 1.36
NTNG1 -0.0002493 9877 GTEx DepMap Descartes 0.03 0.79
FAM155A -0.0002497 9887 GTEx DepMap Descartes 0.06 0.96


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.34e-01
Mean rank of genes in gene set: 5531.52
Median rank of genes in gene set: 5582
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
BLVRB 0.0021509 223 GTEx DepMap Descartes 2.86 440.85
SLC25A37 0.0012077 467 GTEx DepMap Descartes 0.37 21.03
SPECC1 0.0005085 1017 GTEx DepMap Descartes 0.14 3.65
CAT 0.0004762 1059 GTEx DepMap Descartes 0.47 40.14
RAPGEF2 0.0003868 1224 GTEx DepMap Descartes 0.24 5.90
DENND4A 0.0002799 1487 GTEx DepMap Descartes 0.18 4.39
MICAL2 0.0002294 1638 GTEx DepMap Descartes 0.03 1.22
ABCB10 0.0000212 2906 GTEx DepMap Descartes 0.05 2.74
SLC25A21 -0.0000130 3473 GTEx DepMap Descartes 0.00 0.00
ALAS2 -0.0000369 4066 GTEx DepMap Descartes 0.00 0.18
RHD -0.0000477 4395 GTEx DepMap Descartes 0.00 0.00
SLC4A1 -0.0000604 4748 GTEx DepMap Descartes 0.00 0.34
TRAK2 -0.0000656 4905 GTEx DepMap Descartes 0.07 2.32
RGS6 -0.0000808 5374 GTEx DepMap Descartes 0.00 0.06
ANK1 -0.0000876 5582 GTEx DepMap Descartes 0.02 0.45
TFR2 -0.0000997 5906 GTEx DepMap Descartes 0.02 1.13
FECH -0.0001073 6145 GTEx DepMap Descartes 0.08 1.75
TMCC2 -0.0001150 6380 GTEx DepMap Descartes 0.01 0.59
XPO7 -0.0001271 6760 GTEx DepMap Descartes 0.09 2.96
CPOX -0.0001340 6984 GTEx DepMap Descartes 0.03 2.74
GCLC -0.0001400 7155 GTEx DepMap Descartes 0.13 6.71
SELENBP1 -0.0001402 7164 GTEx DepMap Descartes 0.01 0.60
SPTB -0.0001518 7504 GTEx DepMap Descartes 0.02 0.33
SOX6 -0.0001942 8679 GTEx DepMap Descartes 0.01 0.13
SNCA -0.0002160 9173 GTEx DepMap Descartes 0.24 15.87
MARCH3 -0.0002766 10339 GTEx DepMap Descartes 0.06 NA
EPB41 -0.0003674 11434 GTEx DepMap Descartes 0.16 5.47
TSPAN5 -0.0004158 11749 GTEx DepMap Descartes 0.11 4.32
GYPC -0.0008457 12478 GTEx DepMap Descartes 0.75 94.01
NA NA NA NA NA NA NA NA


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.64e-08
Mean rank of genes in gene set: 3115.63
Median rank of genes in gene set: 1011.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CTSS 0.0063267 24 GTEx DepMap Descartes 5.89 298.06
CYBB 0.0049274 45 GTEx DepMap Descartes 1.44 72.47
HCK 0.0046972 53 GTEx DepMap Descartes 0.74 71.94
FGL2 0.0044697 58 GTEx DepMap Descartes 2.26 101.48
PTPRE 0.0036634 78 GTEx DepMap Descartes 1.03 40.66
CST3 0.0030840 107 GTEx DepMap Descartes 20.47 1277.22
CSF1R 0.0025242 163 GTEx DepMap Descartes 1.18 64.14
FGD2 0.0015965 332 GTEx DepMap Descartes 0.18 6.84
CD14 0.0015131 353 GTEx DepMap Descartes 6.70 893.07
MARCH1 0.0014916 360 GTEx DepMap Descartes 0.58 NA
TGFBI 0.0014528 375 GTEx DepMap Descartes 1.26 56.86
CD163 0.0012756 440 GTEx DepMap Descartes 1.16 50.03
ADAP2 0.0008799 640 GTEx DepMap Descartes 0.78 63.95
CPVL 0.0008155 685 GTEx DepMap Descartes 1.83 157.81
IFNGR1 0.0007927 703 GTEx DepMap Descartes 1.06 85.04
CD74 0.0007824 712 GTEx DepMap Descartes 47.20 3048.71
ABCA1 0.0007381 754 GTEx DepMap Descartes 0.87 19.17
RGL1 0.0006219 868 GTEx DepMap Descartes 0.26 10.27
CTSC 0.0005985 902 GTEx DepMap Descartes 4.52 123.92
SFMBT2 0.0004455 1121 GTEx DepMap Descartes 0.16 4.44
MSR1 0.0003436 1318 GTEx DepMap Descartes 0.83 49.11
ITPR2 0.0003365 1334 GTEx DepMap Descartes 0.35 5.64
MERTK 0.0003225 1379 GTEx DepMap Descartes 0.26 14.02
CTSB 0.0003111 1404 GTEx DepMap Descartes 12.11 759.25
ATP8B4 0.0002138 1690 GTEx DepMap Descartes 0.08 3.28
SLC9A9 0.0001341 2031 GTEx DepMap Descartes 0.18 10.49
RBPJ 0.0001333 2037 GTEx DepMap Descartes 0.76 28.39
HRH1 0.0000100 3042 GTEx DepMap Descartes 0.04 1.61
WWP1 -0.0000701 5036 GTEx DepMap Descartes 0.21 7.82
CTSD -0.0000892 5621 GTEx DepMap Descartes 15.43 1761.56


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.51e-01
Mean rank of genes in gene set: 7178.95
Median rank of genes in gene set: 7366.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
VCAN 0.0026139 150 GTEx DepMap Descartes 0.84 22.32
VIM 0.0017223 295 GTEx DepMap Descartes 13.49 1074.93
KCTD12 0.0014152 388 GTEx DepMap Descartes 0.65 22.48
GAS7 0.0009676 590 GTEx DepMap Descartes 0.23 6.27
PAG1 0.0001248 2079 GTEx DepMap Descartes 0.33 7.25
MPZ -0.0000145 3511 GTEx DepMap Descartes 0.06 6.38
ERBB3 -0.0000427 4251 GTEx DepMap Descartes 0.02 0.69
STARD13 -0.0000460 4345 GTEx DepMap Descartes 0.06 2.06
TRPM3 -0.0000509 4494 GTEx DepMap Descartes 0.00 0.07
IL1RAPL2 -0.0000563 4625 GTEx DepMap Descartes 0.00 0.00
MDGA2 -0.0000769 5240 GTEx DepMap Descartes 0.00 0.00
GRIK3 -0.0000796 5339 GTEx DepMap Descartes 0.01 0.10
COL25A1 -0.0000807 5372 GTEx DepMap Descartes 0.01 0.10
MARCKS -0.0000811 5384 GTEx DepMap Descartes 4.64 207.73
HMGA2 -0.0001029 6005 GTEx DepMap Descartes 0.00 0.00
IL1RAPL1 -0.0001093 6205 GTEx DepMap Descartes 0.00 0.16
ERBB4 -0.0001144 6359 GTEx DepMap Descartes 0.01 0.15
PLCE1 -0.0001217 6600 GTEx DepMap Descartes 0.03 0.57
EGFLAM -0.0001354 7028 GTEx DepMap Descartes 0.03 0.61
SCN7A -0.0001410 7187 GTEx DepMap Descartes 0.07 1.61
LRRTM4 -0.0001414 7210 GTEx DepMap Descartes 0.01 0.51
PTPRZ1 -0.0001473 7364 GTEx DepMap Descartes 0.00 0.10
PLP1 -0.0001475 7369 GTEx DepMap Descartes 0.08 4.87
SLC35F1 -0.0001575 7669 GTEx DepMap Descartes 0.02 0.74
LAMC1 -0.0001594 7733 GTEx DepMap Descartes 0.08 1.93
XKR4 -0.0001738 8108 GTEx DepMap Descartes 0.01 0.11
COL18A1 -0.0001748 8147 GTEx DepMap Descartes 0.11 2.82
NRXN3 -0.0001764 8193 GTEx DepMap Descartes 0.01 0.20
FIGN -0.0001889 8538 GTEx DepMap Descartes 0.03 0.49
EDNRB -0.0002109 9071 GTEx DepMap Descartes 0.05 2.32


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.90e-07
Mean rank of genes in gene set: 3687.02
Median rank of genes in gene set: 2197
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PLEK 0.0041173 65 GTEx DepMap Descartes 2.36 185.61
SLC2A3 0.0034649 88 GTEx DepMap Descartes 1.16 64.52
ACTB 0.0030317 113 GTEx DepMap Descartes 36.17 3511.69
TMSB4X 0.0027382 132 GTEx DepMap Descartes 144.34 18204.20
FLNA 0.0025043 170 GTEx DepMap Descartes 0.80 23.62
PSTPIP2 0.0022157 214 GTEx DepMap Descartes 0.19 13.87
LIMS1 0.0021721 221 GTEx DepMap Descartes 1.81 88.83
THBS1 0.0020609 234 GTEx DepMap Descartes 0.27 9.42
FERMT3 0.0013308 418 GTEx DepMap Descartes 0.68 56.23
ZYX 0.0012106 465 GTEx DepMap Descartes 0.62 58.86
TLN1 0.0012010 473 GTEx DepMap Descartes 0.79 19.17
TGFB1 0.0011339 507 GTEx DepMap Descartes 0.90 69.83
MCTP1 0.0011053 524 GTEx DepMap Descartes 0.12 4.09
SPN 0.0009302 607 GTEx DepMap Descartes 0.21 6.63
P2RX1 0.0007913 704 GTEx DepMap Descartes 0.02 2.01
TPM4 0.0007184 769 GTEx DepMap Descartes 1.89 87.82
RAP1B 0.0007176 771 GTEx DepMap Descartes 0.94 14.38
FLI1 0.0006476 840 GTEx DepMap Descartes 0.16 6.38
UBASH3B 0.0005384 969 GTEx DepMap Descartes 0.12 3.95
MYH9 0.0004706 1066 GTEx DepMap Descartes 0.49 14.78
CD84 0.0004171 1163 GTEx DepMap Descartes 0.77 18.80
VCL 0.0001248 2081 GTEx DepMap Descartes 0.10 2.36
GP1BA 0.0001044 2197 GTEx DepMap Descartes 0.00 0.12
GSN 0.0001014 2209 GTEx DepMap Descartes 1.58 41.89
MMRN1 0.0000336 2773 GTEx DepMap Descartes 0.00 0.00
ACTN1 0.0000264 2855 GTEx DepMap Descartes 0.39 16.62
TRPC6 -0.0000154 3530 GTEx DepMap Descartes 0.00 0.12
SLC24A3 -0.0000393 4145 GTEx DepMap Descartes 0.00 0.12
ITGB3 -0.0000622 4801 GTEx DepMap Descartes 0.00 0.07
HIPK2 -0.0000779 5283 GTEx DepMap Descartes 0.20 2.68


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.35e-01
Mean rank of genes in gene set: 6625.29
Median rank of genes in gene set: 8799
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
LCP1 0.0028482 129 GTEx DepMap Descartes 1.67 95.87
CD44 0.0022144 215 GTEx DepMap Descartes 2.15 99.93
TMSB10 0.0016261 327 GTEx DepMap Descartes 60.89 27503.68
B2M 0.0014841 362 GTEx DepMap Descartes 97.62 8340.91
MSN 0.0014025 394 GTEx DepMap Descartes 1.01 57.16
ARHGDIB 0.0013232 423 GTEx DepMap Descartes 4.10 704.78
MBNL1 0.0009198 612 GTEx DepMap Descartes 0.64 21.42
PTPRC 0.0008765 645 GTEx DepMap Descartes 1.61 65.46
SORL1 0.0006870 800 GTEx DepMap Descartes 0.39 9.01
WIPF1 0.0006316 857 GTEx DepMap Descartes 0.69 31.16
RCSD1 0.0004663 1079 GTEx DepMap Descartes 0.31 12.92
PLEKHA2 0.0004169 1164 GTEx DepMap Descartes 0.22 8.87
SP100 0.0003569 1281 GTEx DepMap Descartes 0.50 19.40
DOCK10 0.0003454 1316 GTEx DepMap Descartes 0.27 7.48
CELF2 0.0003213 1386 GTEx DepMap Descartes 0.62 16.61
ANKRD44 0.0002294 1637 GTEx DepMap Descartes 0.25 7.15
IKZF1 0.0000589 2530 GTEx DepMap Descartes 0.32 11.09
ITPKB -0.0000089 3379 GTEx DepMap Descartes 0.06 2.27
RAP1GAP2 -0.0000894 5632 GTEx DepMap Descartes 0.07 2.04
CCND3 -0.0001295 6849 GTEx DepMap Descartes 0.29 25.70
MCTP2 -0.0001889 8537 GTEx DepMap Descartes 0.01 0.30
BACH2 -0.0002101 9061 GTEx DepMap Descartes 0.06 1.41
ARID5B -0.0002611 10081 GTEx DepMap Descartes 0.33 9.02
CCL5 -0.0002722 10273 GTEx DepMap Descartes 0.51 69.87
PITPNC1 -0.0002892 10563 GTEx DepMap Descartes 0.13 3.97
SCML4 -0.0002929 10610 GTEx DepMap Descartes 0.03 1.04
ARHGAP15 -0.0003082 10806 GTEx DepMap Descartes 0.25 17.31
TOX -0.0003423 11190 GTEx DepMap Descartes 0.06 2.54
BCL2 -0.0003539 11311 GTEx DepMap Descartes 0.23 6.62
STK39 -0.0003540 11314 GTEx DepMap Descartes 0.09 4.65


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.99e-05
Mean rank of genes in gene set: 44.4
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FTH1 0.0077057 14 GTEx DepMap Descartes 168.11 31442.59
SRGN 0.0068017 18 GTEx DepMap Descartes 16.42 3137.98
TYROBP 0.0061054 30 GTEx DepMap Descartes 22.81 8449.38
S100A6 0.0048917 47 GTEx DepMap Descartes 7.50 2854.00
ACTB 0.0030317 113 GTEx DepMap Descartes 36.17 3511.69


Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.46e-03
Mean rank of genes in gene set: 50
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TYROBP 0.0061054 30 GTEx DepMap Descartes 22.81 8449.38
SAT1 0.0044569 59 GTEx DepMap Descartes 30.35 5833.53
NEAT1 0.0042416 61 GTEx DepMap Descartes 10.11 103.04


DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.43e-03
Mean rank of genes in gene set: 1072.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CST3 0.0030840 107 GTEx DepMap Descartes 20.47 1277.22
AGRP 0.0004065 1186 GTEx DepMap Descartes 0.01 4.04
MMP9 0.0001556 1925 GTEx DepMap Descartes 1.31 80.36