Program: 12. Schwannian Stromal Cell: GNB.

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QQ-plot of gene loadings, averaged over both independent splits of the data
This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

	Gene	Loading	Gene.Name	GTEx	DepMap	Descartes	Mean.Counts	Mean.Tpm
1	S100B	0.0259059	S100 calcium binding protein B	GTEx	DepMap	Descartes	21.89	9074.86
2	PLP1	0.0233658	proteolipid protein 1	GTEx	DepMap	Descartes	4.44	653.76
3	LGI4	0.0220981	leucine rich repeat LGI family member 4	GTEx	DepMap	Descartes	2.78	437.06
4	FXYD1	0.0218314	FXYD domain containing ion transport regulator 1	GTEx	DepMap	Descartes	3.71	1797.47
5	SEMA3B	0.0213777	semaphorin 3B	GTEx	DepMap	Descartes	3.61	511.41
6	IL34	0.0211231	interleukin 34	GTEx	DepMap	Descartes	1.42	390.19
7	ITGB8	0.0208961	integrin subunit beta 8	GTEx	DepMap	Descartes	2.60	134.09
8	MIA	0.0201307	MIA SH3 domain containing	GTEx	DepMap	Descartes	4.06	2885.00
9	CMTM5	0.0193852	CKLF like MARVEL transmembrane domain containing 5	GTEx	DepMap	Descartes	0.83	202.13
10	GPM6B	0.0193109	glycoprotein M6B	GTEx	DepMap	Descartes	4.63	521.26
11	ITIH5	0.0176003	inter-alpha-trypsin inhibitor heavy chain 5	GTEx	DepMap	Descartes	0.79	47.44
12	GATM	0.0170773	glycine amidinotransferase	GTEx	DepMap	Descartes	1.55	170.83
13	COL14A1	0.0165330	collagen type XIV alpha 1 chain	GTEx	DepMap	Descartes	1.46	85.43
14	SBSPON	0.0156522	somatomedin B and thrombospondin type 1 domain containing	GTEx	DepMap	Descartes	0.98	NA
15	ALDH1A1	0.0141950	aldehyde dehydrogenase 1 family member A1	GTEx	DepMap	Descartes	1.25	273.89
16	RARRES2	0.0135186	retinoic acid receptor responder 2	GTEx	DepMap	Descartes	4.67	982.41
17	ST6GALNAC2	0.0133881	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	GTEx	DepMap	Descartes	0.61	164.14
18	ARHGAP15	0.0133487	Rho GTPase activating protein 15	GTEx	DepMap	Descartes	1.94	309.44
19	PLLP	0.0133173	plasmolipin	GTEx	DepMap	Descartes	0.54	36.07
20	PON2	0.0132064	paraoxonase 2	GTEx	DepMap	Descartes	0.95	221.05
21	MPZ	0.0130732	myelin protein zero	GTEx	DepMap	Descartes	2.96	710.50
22	DHH	0.0129963	desert hedgehog signaling molecule	GTEx	DepMap	Descartes	0.23	22.51
23	ERBB3	0.0127857	erb-b2 receptor tyrosine kinase 3	GTEx	DepMap	Descartes	0.87	62.27
24	IFITM3	0.0126861	interferon induced transmembrane protein 3	GTEx	DepMap	Descartes	20.43	11724.91
25	EMP2	0.0126473	epithelial membrane protein 2	GTEx	DepMap	Descartes	1.45	119.10
26	ASPA	0.0122893	aspartoacylase	GTEx	DepMap	Descartes	0.27	22.38
27	CTNNAL1	0.0121621	catenin alpha like 1	GTEx	DepMap	Descartes	2.36	442.67
28	PLEKHA4	0.0120986	pleckstrin homology domain containing A4	GTEx	DepMap	Descartes	0.90	113.42
29	RELN	0.0119647	reelin	GTEx	DepMap	Descartes	0.54	22.46
30	TTYH1	0.0116816	tweety family member 1	GTEx	DepMap	Descartes	0.85	95.20
31	NTM	0.0112259	neurotrimin	GTEx	DepMap	Descartes	0.99	120.29
32	S100A6	0.0112022	S100 calcium binding protein A6	GTEx	DepMap	Descartes	25.86	14753.98
33	LGALS3BP	0.0111826	galectin 3 binding protein	GTEx	DepMap	Descartes	4.94	957.57
34	PRIMA1	0.0108692	proline rich membrane anchor 1	GTEx	DepMap	Descartes	0.46	62.92
35	MICALL2	0.0108402	MICAL like 2	GTEx	DepMap	Descartes	0.72	58.22
36	SOX2	0.0108086	SRY-box transcription factor 2	GTEx	DepMap	Descartes	0.62	108.15
37	MOXD1	0.0106558	monooxygenase DBH like 1	GTEx	DepMap	Descartes	0.21	33.44
38	SMIM5	0.0105195	small integral membrane protein 5	GTEx	DepMap	Descartes	0.32	NA
39	MATN2	0.0103090	matrilin 2	GTEx	DepMap	Descartes	0.91	92.52
40	FXYD3	0.0102472	FXYD domain containing ion transport regulator 3	GTEx	DepMap	Descartes	0.17	59.40
41	LGI1	0.0100682	leucine rich glioma inactivated 1	GTEx	DepMap	Descartes	0.26	21.29
42	LGALS1	0.0099273	galectin 1	GTEx	DepMap	Descartes	22.85	13754.31
43	FSTL3	0.0098393	follistatin like 3	GTEx	DepMap	Descartes	1.33	179.50
44	GPR37L1	0.0096070	G protein-coupled receptor 37 like 1	GTEx	DepMap	Descartes	0.10	5.80
45	SHC4	0.0096020	SHC adaptor protein 4	GTEx	DepMap	Descartes	0.30	25.04
46	TSC22D4	0.0095335	TSC22 domain family member 4	GTEx	DepMap	Descartes	1.67	296.83
47	SCN7A	0.0095106	sodium voltage-gated channel alpha subunit 7	GTEx	DepMap	Descartes	1.28	82.15
48	PRSS23	0.0093791	serine protease 23	GTEx	DepMap	Descartes	1.67	146.03
49	TIMP3	0.0089899	TIMP metallopeptidase inhibitor 3	GTEx	DepMap	Descartes	3.69	295.24
50	PROS1	0.0089815	protein S	GTEx	DepMap	Descartes	0.66	88.89

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UMAP plots showing activity of gene expression program identified in GEP 12. Schwannian Stromal Cell: GNB:

Interactive UMAP Plot

Interactive Boxplot

CNV Data procured from inferCNV.
Outer tracks are putative CNV regions (gains = red, losses = blue) for each patient
Inner track is expression data representing:
The top cells expressing this GEP (purple)
Random cells (n =50) from the reference set used in inferCNV (orange)

Interactive BioCircos Plot

Gene set Enrichments for this program, caculated from top 50 genes

mSigDB Cell Types Gene Set:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_OLFACTORY_ENSHEATHING_GLIA	7.75e-37	126.42	66.69	5.20e-34	5.20e-34	24S100B, PLP1, LGI4, FXYD1, SEMA3B, ITGB8, MIA, CMTM5, GPM6B, ITIH5, ALDH1A1, RARRES2, ARHGAP15, PON2, MPZ, ERBB3, IFITM3, PLEKHA4, TTYH1, LGALS1, GPR37L1, TSC22D4, SCN7A, TIMP3	115
DESCARTES_FETAL_HEART_SCHWANN_CELLS	2.37e-19	80.98	37.41	7.96e-17	1.59e-16	13S100B, PLP1, LGI4, MIA, ITIH5, ALDH1A1, ST6GALNAC2, MPZ, ERBB3, ASPA, PLEKHA4, PRIMA1, SHC4	67
DESCARTES_FETAL_PANCREAS_ENS_GLIA	4.04e-15	55.82	24.65	5.42e-13	2.71e-12	11S100B, PLP1, LGI4, MIA, CMTM5, MPZ, ERBB3, ASPA, PRIMA1, SOX2, SHC4	74
DESCARTES_FETAL_ADRENAL_SCHWANN_CELLS	9.39e-19	46.91	23.13	2.10e-16	6.30e-16	15S100B, PLP1, LGI4, FXYD1, MIA, GPM6B, ALDH1A1, MPZ, DHH, ERBB3, TTYH1, PRIMA1, SOX2, SHC4, SCN7A	129
DESCARTES_FETAL_INTESTINE_ENS_GLIA	1.05e-12	55.84	22.64	1.17e-10	7.01e-10	9S100B, PLP1, LGI4, CMTM5, MPZ, TTYH1, PRIMA1, SOX2, SHC4	58
DESCARTES_MAIN_FETAL_SCHWANN_CELLS	1.91e-11	55.20	21.15	1.61e-09	1.28e-08	8S100B, PLP1, MIA, MPZ, DHH, ASPA, LGI1, SCN7A	51
DESCARTES_FETAL_MUSCLE_SCHWANN_CELLS	4.80e-16	42.17	19.96	8.05e-14	3.22e-13	13S100B, PLP1, SEMA3B, ITGB8, PLLP, MPZ, DHH, ASPA, PLEKHA4, TTYH1, PRIMA1, SOX2, MOXD1	117
DESCARTES_FETAL_STOMACH_ENS_GLIA	3.10e-08	40.47	13.39	1.73e-06	2.08e-05	6S100B, PLP1, LGI4, MPZ, PRIMA1, MOXD1	48
ZHONG_PFC_MAJOR_TYPES_OPC	2.21e-09	28.66	11.27	1.48e-07	1.48e-06	8S100B, ITGB8, GPM6B, GATM, PLLP, PON2, TTYH1, TSC22D4	91
HU_FETAL_RETINA_MULLER	6.13e-07	37.43	10.99	2.74e-05	4.11e-04	5PLP1, LGI4, GPM6B, TTYH1, SOX2	42
FAN_EMBRYONIC_CTX_BIG_GROUPS_GLIAL	2.03e-09	22.12	9.25	1.48e-07	1.37e-06	9S100B, ITGB8, GPM6B, GATM, PON2, TTYH1, NTM, SOX2, TSC22D4	133
ZHONG_PFC_MAJOR_TYPES_ASTROCYTES	1.34e-11	15.63	7.71	1.28e-09	8.96e-09	14S100B, FXYD1, GPM6B, GATM, PON2, IFITM3, TTYH1, LGALS3BP, SOX2, LGI1, LGALS1, GPR37L1, TSC22D4, TIMP3	325
ZHONG_PFC_C9_ORG_OTHER	8.45e-07	22.11	7.48	3.34e-05	5.67e-04	6ITGB8, GPM6B, GATM, TTYH1, NTM, MOXD1	83
CUI_DEVELOPING_HEART_C6_EPICARDIAL_CELL	3.37e-09	16.89	7.41	2.06e-07	2.26e-06	10SEMA3B, ITGB8, SBSPON, RARRES2, PLLP, PLEKHA4, S100A6, LGALS3BP, PRSS23, PROS1	195
AIZARANI_LIVER_C21_STELLATE_CELLS_1	5.33e-08	14.83	6.24	2.75e-06	3.58e-05	9COL14A1, ALDH1A1, IFITM3, LGALS3BP, MATN2, LGALS1, PRSS23, TIMP3, PROS1	194
TRAVAGLINI_LUNG_ALVEOLAR_FIBROBLAST_CELL	3.28e-06	12.96	4.84	1.22e-04	2.20e-03	7GPM6B, ALDH1A1, RARRES2, EMP2, MOXD1, SCN7A, TIMP3	164
MANNO_MIDBRAIN_NEUROTYPES_HRGL2C	3.94e-07	9.89	4.37	1.89e-05	2.65e-04	10ITGB8, GPM6B, GATM, PLLP, PON2, ERBB3, RELN, TTYH1, SOX2, TSC22D4	326
TRAVAGLINI_LUNG_CAPILLARY_AEROCYTE_CELL	6.07e-04	20.43	3.90	1.13e-02	4.07e-01	3EMP2, S100A6, LGALS1	42
CUI_DEVELOPING_HEART_C5_VALVAR_CELL	1.53e-05	10.12	3.80	5.11e-04	1.02e-02	7S100B, ERBB3, CTNNAL1, S100A6, MATN2, LGALS1, TIMP3	208
MANNO_MIDBRAIN_NEUROTYPES_HRGL2B	6.74e-07	8.22	3.77	2.83e-05	4.52e-04	11PLP1, ITGB8, CMTM5, GPM6B, GATM, PON2, MPZ, TTYH1, SOX2, TSC22D4, TIMP3	440

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mSigDB Hallmark Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	1.08e-03	7.12	2.18	5.40e-02	5.40e-02	5NTM, MATN2, LGALS1, FSTL3, TIMP3	200
HALLMARK_ESTROGEN_RESPONSE_LATE	7.71e-03	5.55	1.44	1.93e-01	3.85e-01	4SEMA3B, ST6GALNAC2, EMP2, PRSS23	200
HALLMARK_COAGULATION	1.70e-02	5.91	1.16	2.83e-01	8.50e-01	3PRSS23, TIMP3, PROS1	138
HALLMARK_APOPTOSIS	2.53e-02	5.05	0.99	3.17e-01	1.00e+00	3ERBB3, IFITM3, TIMP3	161
HALLMARK_INTERFERON_ALPHA_RESPONSE	5.62e-02	5.48	0.64	5.62e-01	1.00e+00	2IFITM3, LGALS3BP	97
HALLMARK_FATTY_ACID_METABOLISM	1.28e-01	3.34	0.39	8.40e-01	1.00e+00	2ALDH1A1, LGALS1	158
HALLMARK_IL2_STAT5_SIGNALING	1.83e-01	2.64	0.31	8.40e-01	1.00e+00	2ITIH5, IFITM3	199
HALLMARK_ESTROGEN_RESPONSE_EARLY	1.85e-01	2.63	0.31	8.40e-01	1.00e+00	2SEMA3B, PRSS23	200
HALLMARK_MYOGENESIS	1.85e-01	2.63	0.31	8.40e-01	1.00e+00	2FXYD1, ERBB3	200
HALLMARK_INTERFERON_GAMMA_RESPONSE	1.85e-01	2.63	0.31	8.40e-01	1.00e+00	2IFITM3, LGALS3BP	200
HALLMARK_KRAS_SIGNALING_UP	1.85e-01	2.63	0.31	8.40e-01	1.00e+00	2SEMA3B, RELN	200
HALLMARK_CHOLESTEROL_HOMEOSTASIS	2.55e-01	3.49	0.09	1.00e+00	1.00e+00	1SEMA3B	74
HALLMARK_PEROXISOME	3.39e-01	2.48	0.06	1.00e+00	1.00e+00	1ALDH1A1	104
HALLMARK_BILE_ACID_METABOLISM	3.59e-01	2.30	0.06	1.00e+00	1.00e+00	1ALDH1A1	112
HALLMARK_ADIPOGENESIS	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1ITIH5	200
HALLMARK_INFLAMMATORY_RESPONSE	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1ITGB8	200
HALLMARK_XENOBIOTIC_METABOLISM	5.47e-01	1.28	0.03	1.00e+00	1.00e+00	1PROS1	200
HALLMARK_TNFA_SIGNALING_VIA_NFKB	1.00e+00	0.00	0.00	1.00e+00	1.00e+00	0	200
HALLMARK_HYPOXIA	1.00e+00	0.00	0.00	1.00e+00	1.00e+00	0	200
HALLMARK_MITOTIC_SPINDLE	1.00e+00	0.00	0.00	1.00e+00	1.00e+00	0	199

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KEGG Pathways:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
KEGG_FOCAL_ADHESION	4.30e-02	4.07	0.80	1.00e+00	1.00e+00	3ITGB8, RELN, SHC4	199
KEGG_ECM_RECEPTOR_INTERACTION	4.36e-02	6.35	0.74	1.00e+00	1.00e+00	2ITGB8, RELN	84
KEGG_ERBB_SIGNALING_PATHWAY	4.64e-02	6.13	0.71	1.00e+00	1.00e+00	2ERBB3, SHC4	87
KEGG_CELL_ADHESION_MOLECULES_CAMS	9.66e-02	3.98	0.46	1.00e+00	1.00e+00	2ITGB8, MPZ	133
KEGG_HISTIDINE_METABOLISM	1.09e-01	9.11	0.22	1.00e+00	1.00e+00	1ASPA	29
KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM	1.16e-01	8.50	0.20	1.00e+00	1.00e+00	1GATM	31
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM	1.20e-01	8.23	0.20	1.00e+00	1.00e+00	1ASPA	32
KEGG_ARGININE_AND_PROLINE_METABOLISM	1.94e-01	4.81	0.12	1.00e+00	1.00e+00	1GATM	54
KEGG_HEDGEHOG_SIGNALING_PATHWAY	2.00e-01	4.64	0.11	1.00e+00	1.00e+00	1DHH	56
KEGG_RETINOL_METABOLISM	2.25e-01	4.05	0.10	1.00e+00	1.00e+00	1ALDH1A1	64
KEGG_GLIOMA	2.28e-01	3.99	0.10	1.00e+00	1.00e+00	1SHC4	65
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	2.40e-01	3.75	0.09	1.00e+00	1.00e+00	1PROS1	69
KEGG_CHRONIC_MYELOID_LEUKEMIA	2.52e-01	3.54	0.09	1.00e+00	1.00e+00	1SHC4	73
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	2.55e-01	3.49	0.09	1.00e+00	1.00e+00	1ITGB8	74
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	2.81e-01	3.11	0.08	1.00e+00	1.00e+00	1ITGB8	83
KEGG_DILATED_CARDIOMYOPATHY	3.01e-01	2.87	0.07	1.00e+00	1.00e+00	1ITGB8	90
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	3.94e-01	2.04	0.05	1.00e+00	1.00e+00	1SHC4	126
KEGG_AXON_GUIDANCE	4.01e-01	1.99	0.05	1.00e+00	1.00e+00	1SEMA3B	129
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	4.20e-01	1.88	0.05	1.00e+00	1.00e+00	1SHC4	137
KEGG_INSULIN_SIGNALING_PATHWAY	4.20e-01	1.88	0.05	1.00e+00	1.00e+00	1SHC4	137

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CHR Positional Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
chr17q25	1.09e-01	2.71	0.54	1.00e+00	1.00e+00	3ST6GALNAC2, LGALS3BP, SMIM5	297
chr19q13	3.15e-01	1.47	0.51	1.00e+00	1.00e+00	6LGI4, FXYD1, MIA, PLEKHA4, TTYH1, FXYD3	1165
chr15q21	1.40e-01	3.16	0.37	1.00e+00	1.00e+00	2GATM, SHC4	167
chr7q22	2.03e-01	2.47	0.29	1.00e+00	1.00e+00	2RELN, TSC22D4	213
chr11q25	1.16e-01	8.50	0.20	1.00e+00	1.00e+00	1NTM	31
chr16q13	1.47e-01	6.54	0.16	1.00e+00	1.00e+00	1PLLP	40
chr12q13	6.71e-01	1.29	0.15	1.00e+00	1.00e+00	2DHH, ERBB3	407
chr10p14	1.71e-01	5.54	0.13	1.00e+00	1.00e+00	1ITIH5	47
chr3q11	1.81e-01	5.21	0.13	1.00e+00	1.00e+00	1PROS1	50
chr2q22	2.37e-01	3.81	0.09	1.00e+00	1.00e+00	1ARHGAP15	68
chr7p21	2.81e-01	3.11	0.08	1.00e+00	1.00e+00	1ITGB8	83
chr6q23	3.44e-01	2.43	0.06	1.00e+00	1.00e+00	1MOXD1	106
chr7p22	3.82e-01	2.13	0.05	1.00e+00	1.00e+00	1MICALL2	121
chr2q24	3.91e-01	2.06	0.05	1.00e+00	1.00e+00	1SCN7A	125
chr9q31	3.99e-01	2.01	0.05	1.00e+00	1.00e+00	1CTNNAL1	128
chr11q14	4.29e-01	1.82	0.04	1.00e+00	1.00e+00	1PRSS23	141
chr7q36	4.38e-01	1.77	0.04	1.00e+00	1.00e+00	1RARRES2	145
chr8q22	4.55e-01	1.68	0.04	1.00e+00	1.00e+00	1MATN2	153
chr7q21	4.78e-01	1.56	0.04	1.00e+00	1.00e+00	1PON2	164
chrXq22	4.88e-01	1.52	0.04	1.00e+00	1.00e+00	1PLP1	169

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Transcription Factor Targets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
CAGCTG_AP4_Q5	4.71e-05	3.89	2.00	5.33e-02	5.33e-02	16PLP1, LGI4, IL34, ITGB8, CMTM5, GPM6B, ALDH1A1, ERBB3, ASPA, PLEKHA4, SOX2, FXYD3, LGI1, LGALS1, GPR37L1, TSC22D4	1530
ZIC1_01	3.67e-03	5.32	1.64	7.09e-01	1.00e+00	5SEMA3B, ERBB3, LGI1, FSTL3, TSC22D4	266
STTTCRNTTT_IRF_Q6	6.70e-03	5.78	1.50	7.09e-01	1.00e+00	4ALDH1A1, ASPA, LGALS3BP, LGI1	192
WTGAAAT_UNKNOWN	8.85e-03	3.29	1.24	7.09e-01	1.00e+00	7IL34, GPM6B, SBSPON, ASPA, CTNNAL1, SOX2, SCN7A	625
ZIC2_01	1.66e-02	4.38	1.14	7.09e-01	1.00e+00	4SEMA3B, ERBB3, TSC22D4, TIMP3	252
ICSBP_Q6	1.69e-02	4.37	1.13	7.09e-01	1.00e+00	4PLP1, ALDH1A1, ASPA, LGI1	253
ZIC3_01	1.73e-02	4.33	1.12	7.09e-01	1.00e+00	4SEMA3B, ERBB3, FSTL3, TIMP3	255
HNF4_DR1_Q3	2.00e-02	4.13	1.07	7.09e-01	1.00e+00	4LGI4, FXYD1, SEMA3B, ERBB3	267
ZID_01	2.05e-02	4.10	1.06	7.09e-01	1.00e+00	4PLP1, CMTM5, ERBB3, TSC22D4	269
HEB_Q6	2.05e-02	4.10	1.06	7.09e-01	1.00e+00	4IL34, ERBB3, GPR37L1, TSC22D4	269
AP4_Q5	2.13e-02	4.06	1.05	7.09e-01	1.00e+00	4CMTM5, GPM6B, ALDH1A1, ERBB3	272
ZNF596_TARGET_GENES	3.65e-02	2.62	0.91	9.14e-01	1.00e+00	6COL14A1, ERBB3, SOX2, LGALS1, TSC22D4, TIMP3	656
GCANCTGNY_MYOD_Q6	8.29e-02	2.19	0.83	9.14e-01	1.00e+00	7IL34, ALDH1A1, ERBB3, PLEKHA4, SOX2, LGALS1, GPR37L1	935
AAANWWTGC_UNKNOWN	4.09e-02	4.16	0.82	9.14e-01	1.00e+00	3ASPA, PRIMA1, TSC22D4	195
HFH8_01	4.79e-02	3.89	0.77	9.14e-01	1.00e+00	3ASPA, PRIMA1, SOX2	208
RREB1_01	4.84e-02	3.87	0.76	9.14e-01	1.00e+00	3ITGB8, DHH, TIMP3	209
SIX1_TARGET_GENES	5.70e-02	2.92	0.76	9.14e-01	1.00e+00	4SEMA3B, GATM, ARHGAP15, IFITM3	376
MAZR_01	5.71e-02	3.61	0.71	9.14e-01	1.00e+00	3FXYD1, FXYD3, LGALS1	224
SRF_Q5_01	5.78e-02	3.59	0.71	9.14e-01	1.00e+00	3ITGB8, ASPA, TIMP3	225
CTGYNNCTYTAA_UNKNOWN	4.73e-02	6.05	0.70	9.14e-01	1.00e+00	2PLP1, FXYD3	88

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GO Biological Processes:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GOBP_ENSHEATHMENT_OF_NEURONS	9.51e-06	14.20	4.85	3.04e-02	7.12e-02	6PLP1, LGI4, PLLP, MPZ, DHH, ASPA	126
GOBP_GLIAL_CELL_DIFFERENTIATION	1.40e-06	11.78	4.72	1.05e-02	1.05e-02	8PLP1, LGI4, IL34, ERBB3, ASPA, RELN, SOX2, GPR37L1	210
GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS	2.03e-03	34.68	3.75	1.00e+00	1.00e+00	2IL34, RARRES2	17
GOBP_GLIOGENESIS	1.22e-05	8.66	3.48	3.04e-02	9.11e-02	8PLP1, LGI4, IL34, ERBB3, ASPA, RELN, SOX2, GPR37L1	283
GOBP_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM	3.10e-03	27.37	3.01	1.00e+00	1.00e+00	2PLP1, ASPA	21
GOBP_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION	3.40e-03	26.01	2.87	1.00e+00	1.00e+00	2IL34, ASPA	22
GOBP_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY	1.71e-03	13.99	2.71	1.00e+00	1.00e+00	3IL34, ERBB3, RELN	60
GOBP_POSITIVE_REGULATION_OF_MACROPHAGE_MIGRATION	4.05e-03	23.65	2.62	1.00e+00	1.00e+00	2IL34, RARRES2	24
GOBP_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION	2.45e-03	12.27	2.38	1.00e+00	1.00e+00	3IL34, ASPA, GPR37L1	68
GOBP_REGULATION_OF_MACROPHAGE_CHEMOTAXIS	5.10e-03	20.80	2.32	1.00e+00	1.00e+00	2IL34, RARRES2	27
GOBP_PLATELET_DEGRANULATION	1.59e-03	8.76	2.26	1.00e+00	1.00e+00	4RARRES2, LGALS3BP, TIMP3, PROS1	128
GOBP_NEUROTRANSMITTER_METABOLIC_PROCESS	5.87e-03	19.27	2.16	1.00e+00	1.00e+00	2PRIMA1, MOXD1	29
GOBP_NEUROGENESIS	8.33e-05	3.69	1.90	1.56e-01	6.23e-01	16S100B, PLP1, LGI4, SEMA3B, IL34, GPM6B, ERBB3, ASPA, RELN, NTM, S100A6, MICALL2, SOX2, LGI1, LGALS1, GPR37L1	1613
GOBP_BIOLOGICAL_ADHESION	1.32e-04	3.66	1.85	1.97e-01	9.86e-01	15ITGB8, GPM6B, COL14A1, MPZ, ERBB3, EMP2, CTNNAL1, RELN, TTYH1, NTM, LGALS3BP, MICALL2, SOX2, LGALS1, FSTL3	1481
GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE	5.37e-03	9.17	1.79	1.00e+00	1.00e+00	3RARRES2, EMP2, GPR37L1	90
GOBP_SCHWANN_CELL_DIFFERENTIATION	8.94e-03	15.30	1.73	1.00e+00	1.00e+00	2LGI4, ERBB3	36
GOBP_REGULATION_OF_GLIOGENESIS	5.88e-03	8.86	1.73	1.00e+00	1.00e+00	3IL34, ASPA, GPR37L1	93
GOBP_OLIGODENDROCYTE_DIFFERENTIATION	5.88e-03	8.86	1.73	1.00e+00	1.00e+00	3PLP1, IL34, ASPA	93
GOBP_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY	6.06e-03	8.76	1.71	1.00e+00	1.00e+00	3IL34, ERBB3, RELN	94
GOBP_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION	9.43e-03	14.87	1.69	1.00e+00	1.00e+00	2IL34, ASPA	37

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Immunological Gene Sets:

	P-value	OR	Lower 95% CI	FDR	FWER	Genes Found	Gene Set Size
GSE25123_WT_VS_PPARG_KO_MACROPHAGE_IL4_STIM_DN	1.24e-04	8.78	3.02	6.03e-01	6.03e-01	6ITGB8, GPM6B, ITIH5, ERBB3, S100A6, LGALS1	200
GSE13522_WT_VS_IFNAR_KO_SKIN_DN	6.28e-04	8.07	2.47	1.00e+00	1.00e+00	5GATM, ERBB3, S100A6, LGALS3BP, LGALS1	177
GSE22589_HEALTHY_VS_HIV_INFECTED_DC_DN	1.08e-03	7.12	2.18	1.00e+00	1.00e+00	5S100B, IFITM3, CTNNAL1, LGALS3BP, MATN2	200
GSE26030_TH1_VS_TH17_DAY15_POST_POLARIZATION_DN	1.08e-03	7.12	2.18	1.00e+00	1.00e+00	5ARHGAP15, IFITM3, S100A6, SMIM5, LGALS1	200
GSE21927_SPLENIC_C26GM_TUMOROUS_VS_4T1_TUMOR_MONOCYTES_UP	5.90e-03	6.00	1.55	1.00e+00	1.00e+00	4GPM6B, COL14A1, MICALL2, TIMP3	185
GSE22611_UNSTIM_VS_6H_MDP_STIM_NOD2_TRANSDUCED_HEK293T_CELL_UP	7.20e-03	5.66	1.47	1.00e+00	1.00e+00	4PLLP, CTNNAL1, S100A6, LGALS3BP	196
GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_DN	7.45e-03	5.60	1.45	1.00e+00	1.00e+00	4PLLP, DHH, IFITM3, MOXD1	198
GSE19888_ADENOSINE_A3R_INH_VS_ACT_IN_MAST_CELL_DN	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4GPM6B, GATM, ARHGAP15, IFITM3	199
GSE16450_CTRL_VS_IFNA_6H_STIM_MATURE_NEURON_CELL_LINE_UP	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4ITIH5, NTM, LGI1, TSC22D4	199
GSE26727_WT_VS_KLF2_KO_LPS_STIM_MACROPHAGE_UP	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4ITGB8, COL14A1, TSC22D4, SCN7A	199
GSE35543_IN_VIVO_NTREG_VS_IN_VITRO_ITREG_UP	7.58e-03	5.57	1.44	1.00e+00	1.00e+00	4SEMA3B, IL34, RELN, SCN7A	199
GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4GPM6B, S100A6, LGALS1, PROS1	200
GSE22886_DC_VS_MONOCYTE_UP	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4S100B, PON2, CTNNAL1, MICALL2	200
GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4IFITM3, CTNNAL1, S100A6, LGALS3BP	200
GSE9650_NAIVE_VS_EXHAUSTED_CD8_TCELL_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4GPM6B, ST6GALNAC2, RELN, SCN7A	200
GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4ARHGAP15, IFITM3, S100A6, LGALS1	200
GSE8921_3H_VS_24H_TLR1_2_STIM_MONOCYTE_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4S100A6, MICALL2, LGALS1, TSC22D4	200
GSE5679_CTRL_VS_PPARG_LIGAND_ROSIGLITAZONE_AND_RARA_AGONIST_AM580_TREATED_DC_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4RARRES2, S100A6, LGALS1, FSTL3	200
GSE7219_WT_VS_NIK_NFKB2_KO_LPS_AND_ANTI_CD40_STIM_DC_UP	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4ITIH5, ST6GALNAC2, IFITM3, TIMP3	200
GSE16451_CTRL_VS_WEST_EQUINE_ENC_VIRUS_MATURE_NEURON_CELL_LINE_DN	7.71e-03	5.55	1.44	1.00e+00	1.00e+00	4ITIH5, IFITM3, S100A6, LGALS1	200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol	TF Rank	DNA Binding Domain	Motif Status	IUPAC PWM	GTEx	DepMap	Decartes
PLEKHA4	28	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	Has a putative AT-hook	No DBDs; no indication of DNA binding - included only because Vasquerizas 2009 included it with an x.
RELN	29	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein is a large secreted extracellular matrix protein
SOX2	36	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
TSC22D4	46	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF.
NDP	65	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity. Not DNA binding.
AHR	83	Yes	Known motif	Monomer or homomultimer	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	None
RCAN1	88	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	SH3 domain protein that interacts with calcineurin. GO annotation and abstract in (PMID: 8595418) appear erroneous - mentions a binding domain in the abstract, but no evidence is provided in the paper.
VGLL3	89	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 23380592) describes this protein as a co-activator, and it doesnt seem to have a DBD (fig. 1)
SPHK1	98	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
CLU	99	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of NF-kappaB transcription factor activity, but there is no DBD and no evidence of DNA binding.
PRNP	117	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	None
GAS7	121	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	(PMID: 9736752) only shows that it has a proline-rich domain similar to the one in Oct2. No evidence of DNA binding.
ANXA3	126	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Protein operates far upstream on the signaling cascade.
HOXB7	129	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	None
PRDM16	132	Yes	Inferred motif	Monomer or homomultimer	In vivo/Misc source	None	None
GULP1	180	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
CAPN3	190	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	Included only because GO says positive regulation of NF-kappaB transcription factor activity. No indication of sequence specific DNA binding.
ID3	206	No	Unlikely to be sequence specific TF	Not a DNA binding protein	No motif	None	ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
PARP10	218	No	ssDNA/RNA binding	Not a DNA binding protein	No motif	None	Contains two RRM domains, so likely an RNA-binding protein. Myc-interacting factor capable of ADP-ribosylating itself and core histones (PMID: 15674325).
RXRG	220	Yes	Known motif	Monomer or homomultimer	High-throughput in vitro	None	Usually binds in vivo as a heterodimer, but can bind as a homodimer in vitro

QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID	Singler label	Singler Delta	Activity Score	Top Singler Raw Scores
T19_CCCTCCTAGCACGCCT.1	Neurons:Schwann_cell	0.18	1346.65	Raw ScoresNeurons:Schwann_cell: 0.37, Fibroblasts:foreskin: 0.27, Fibroblasts:breast: 0.27, Tissue_stem_cells:BM_MSC:BMP2: 0.27, Smooth_muscle_cells:bronchial: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, iPS_cells:foreskin_fibrobasts: 0.26, iPS_cells:adipose_stem_cells: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26
T19_CTACACCGTGTGGTTT.1	Neurons:Schwann_cell	0.16	1062.21	Raw ScoresNeurons:Schwann_cell: 0.4, Fibroblasts:breast: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.33, iPS_cells:adipose_stem_cells: 0.32, Smooth_muscle_cells:bronchial: 0.32, Chondrocytes:MSC-derived: 0.32, Fibroblasts:foreskin: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32, Tissue_stem_cells:BM_MSC: 0.32
T19_ATTATCCTCCTTCAAT.1	DC:monocyte-derived:LPS	0.12	1046.28	Raw ScoresDC:monocyte-derived:AEC-conditioned: 0.36, DC:monocyte-derived:LPS: 0.36, DC:monocyte-derived:Poly(IC): 0.36, Macrophage:monocyte-derived:M-CSF: 0.36, Monocyte:leukotriene_D4: 0.36, DC:monocyte-derived:Galectin-1: 0.36, DC:monocyte-derived:anti-DC-SIGN_2h: 0.36, Macrophage:monocyte-derived:IFNa: 0.35, DC:monocyte-derived:A._fumigatus_germ_tubes_6h: 0.35, Macrophage:monocyte-derived:S._aureus: 0.35
T19_TGCCCTAAGCTAAACA.1	Neurons:Schwann_cell	0.14	1025.36	Raw ScoresNeurons:Schwann_cell: 0.41, Fibroblasts:breast: 0.35, Fibroblasts:foreskin: 0.35, iPS_cells:adipose_stem_cells: 0.34, iPS_cells:foreskin_fibrobasts: 0.34, Smooth_muscle_cells:bronchial: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.34, Smooth_muscle_cells:bronchial:vit_D: 0.33, Tissue_stem_cells:BM_MSC:TGFb3: 0.33, iPS_cells:CRL2097_foreskin: 0.33
T19_ACACCGGAGCGAGAAA.1	Neurons:Schwann_cell	0.13	909.22	Raw ScoresNeurons:Schwann_cell: 0.39, Smooth_muscle_cells:bronchial: 0.32, Fibroblasts:foreskin: 0.32, iPS_cells:adipose_stem_cells: 0.31, Fibroblasts:breast: 0.31, Endothelial_cells:HUVEC:IFNg: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, Tissue_stem_cells:BM_MSC:BMP2: 0.31, Endothelial_cells:lymphatic:TNFa_48h: 0.31, Tissue_stem_cells:BM_MSC:TGFb3: 0.3
T19_CTCAGAATCAACGCTA.1	Neurons:Schwann_cell	0.15	819.29	Raw ScoresNeurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial: 0.3, Fibroblasts:foreskin: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.29, Fibroblasts:breast: 0.28, Tissue_stem_cells:BM_MSC:BMP2: 0.28, iPS_cells:adipose_stem_cells: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, Endothelial_cells:lymphatic:TNFa_48h: 0.27, Tissue_stem_cells:iliac_MSC: 0.27
T19_GGATTACTCCTGCCAT.1	Neurons:Schwann_cell	0.14	794.15	Raw ScoresNeurons:Schwann_cell: 0.37, Fibroblasts:foreskin: 0.3, Smooth_muscle_cells:bronchial: 0.3, Smooth_muscle_cells:bronchial:vit_D: 0.3, Endothelial_cells:lymphatic:TNFa_48h: 0.3, Tissue_stem_cells:BM_MSC:BMP2: 0.29, Fibroblasts:breast: 0.29, Endothelial_cells:HUVEC:IFNg: 0.29, iPS_cells:adipose_stem_cells: 0.29, Tissue_stem_cells:BM_MSC:osteogenic: 0.29
T19_ACACCGGAGGGAAACA.1	Neurons:Schwann_cell	0.13	756.30	Raw ScoresNeurons:Schwann_cell: 0.37, Fibroblasts:breast: 0.3, iPS_cells:adipose_stem_cells: 0.3, Tissue_stem_cells:BM_MSC:BMP2: 0.3, Smooth_muscle_cells:bronchial: 0.3, Smooth_muscle_cells:bronchial:vit_D: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Smooth_muscle_cells:vascular: 0.29, Smooth_muscle_cells:vascular:IL-17: 0.29, Fibroblasts:foreskin: 0.29
T19_TGCTACCCAGACACTT.1	Neurons:Schwann_cell	0.14	749.50	Raw ScoresNeurons:Schwann_cell: 0.37, Fibroblasts:breast: 0.3, Smooth_muscle_cells:bronchial: 0.29, iPS_cells:adipose_stem_cells: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.29, Tissue_stem_cells:iliac_MSC: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Chondrocytes:MSC-derived: 0.29, Tissue_stem_cells:BM_MSC: 0.29
T19_GAATAAGCAGGACCCT.1	Neurons:Schwann_cell	0.16	732.34	Raw ScoresNeurons:Schwann_cell: 0.38, Fibroblasts:breast: 0.31, Smooth_muscle_cells:bronchial: 0.31, Fibroblasts:foreskin: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, iPS_cells:adipose_stem_cells: 0.31, Tissue_stem_cells:BM_MSC: 0.31, Tissue_stem_cells:BM_MSC:BMP2: 0.31, Smooth_muscle_cells:vascular:IL-17: 0.3, Tissue_stem_cells:BM_MSC:TGFb3: 0.3
T19_TTTACTGAGACAAAGG.1	Neurons:Schwann_cell	0.15	730.45	Raw ScoresNeurons:Schwann_cell: 0.36, Fibroblasts:breast: 0.3, Smooth_muscle_cells:bronchial: 0.29, iPS_cells:adipose_stem_cells: 0.29, Fibroblasts:foreskin: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.28, Tissue_stem_cells:iliac_MSC: 0.28, iPS_cells:foreskin_fibrobasts: 0.28
T19_CAGCGACGTGGCGAAT.1	Neurons:Schwann_cell	0.14	718.73	Raw ScoresNeurons:Schwann_cell: 0.36, Fibroblasts:foreskin: 0.3, Fibroblasts:breast: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.29, iPS_cells:adipose_stem_cells: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, Smooth_muscle_cells:bronchial: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, Tissue_stem_cells:iliac_MSC: 0.28, Osteoblasts: 0.28
T19_GGCGACTGTTTGTGTG.1	Neurons:Schwann_cell	0.14	716.56	Raw ScoresNeurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial: 0.3, Smooth_muscle_cells:bronchial:vit_D: 0.3, Fibroblasts:breast: 0.3, iPS_cells:adipose_stem_cells: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Fibroblasts:foreskin: 0.29, iPS_cells:foreskin_fibrobasts: 0.29, Tissue_stem_cells:BM_MSC: 0.29
T19_TCGTAGAAGCAGGTCA.1	Neurons:Schwann_cell	0.15	682.96	Raw ScoresNeurons:Schwann_cell: 0.37, Smooth_muscle_cells:bronchial: 0.3, Smooth_muscle_cells:bronchial:vit_D: 0.29, Endothelial_cells:HUVEC:IFNg: 0.28, Fibroblasts:breast: 0.28, Fibroblasts:foreskin: 0.28, iPS_cells:adipose_stem_cells: 0.28, Tissue_stem_cells:BM_MSC:BMP2: 0.28, Smooth_muscle_cells:vascular: 0.28, Smooth_muscle_cells:vascular:IL-17: 0.28
T19_TTCTCCTCAACGCACC.1	Neurons:Schwann_cell	0.14	663.07	Raw ScoresNeurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial: 0.29, Fibroblasts:foreskin: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.29, Fibroblasts:breast: 0.29, Tissue_stem_cells:iliac_MSC: 0.29, iPS_cells:adipose_stem_cells: 0.28, Tissue_stem_cells:BM_MSC:BMP2: 0.28, iPS_cells:foreskin_fibrobasts: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28
T19_CTGATAGCAGCCTTTC.1	Neurons:Schwann_cell	0.13	661.73	Raw ScoresNeurons:Schwann_cell: 0.38, Fibroblasts:foreskin: 0.32, Smooth_muscle_cells:bronchial: 0.31, iPS_cells:adipose_stem_cells: 0.31, Endothelial_cells:HUVEC:IFNg: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, Tissue_stem_cells:BM_MSC:BMP2: 0.3, Fibroblasts:breast: 0.3, Endothelial_cells:lymphatic:TNFa_48h: 0.3, iPS_cells:foreskin_fibrobasts: 0.3
T19_TACCTTAAGACTGTAA.1	Neurons:Schwann_cell	0.15	656.48	Raw ScoresNeurons:Schwann_cell: 0.34, Smooth_muscle_cells:bronchial: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.28, Tissue_stem_cells:BM_MSC:BMP2: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, Fibroblasts:foreskin: 0.27, Tissue_stem_cells:iliac_MSC: 0.27, Chondrocytes:MSC-derived: 0.27, Osteoblasts: 0.27, Fibroblasts:breast: 0.27
T19_CATATTCTCGGCTACG.1	Neurons:Schwann_cell	0.14	655.53	Raw ScoresNeurons:Schwann_cell: 0.34, Fibroblasts:breast: 0.28, Smooth_muscle_cells:bronchial: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.27, iPS_cells:adipose_stem_cells: 0.27, Smooth_muscle_cells:vascular: 0.27, Fibroblasts:foreskin: 0.27, Smooth_muscle_cells:vascular:IL-17: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26
T19_CTAGTGATCTTCCTTC.1	Neurons:Schwann_cell	0.13	619.45	Raw ScoresNeurons:Schwann_cell: 0.37, Tissue_stem_cells:BM_MSC:BMP2: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Tissue_stem_cells:iliac_MSC: 0.29, Fibroblasts:breast: 0.29, Smooth_muscle_cells:bronchial: 0.28, iPS_cells:adipose_stem_cells: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, Endothelial_cells:lymphatic:TNFa_48h: 0.28
T19_AGGCCGTGTGCCTTGG.1	Neurons:Schwann_cell	0.16	619.18	Raw ScoresNeurons:Schwann_cell: 0.36, Tissue_stem_cells:iliac_MSC: 0.28, Smooth_muscle_cells:bronchial: 0.27, Fibroblasts:breast: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Tissue_stem_cells:BM_MSC:BMP2: 0.27, iPS_cells:adipose_stem_cells: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.27, Endothelial_cells:lymphatic:TNFa_48h: 0.27
T19_CCGTGGAAGAGGTAGA.1	Neurons:Schwann_cell	0.14	615.36	Raw ScoresNeurons:Schwann_cell: 0.34, Smooth_muscle_cells:bronchial: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Fibroblasts:foreskin: 0.27, Tissue_stem_cells:BM_MSC:BMP2: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Tissue_stem_cells:iliac_MSC: 0.26, Fibroblasts:breast: 0.26, Endothelial_cells:HUVEC:IFNg: 0.26, iPS_cells:adipose_stem_cells: 0.26
T19_GGACATTCACGGCCAT.1	Neurons:Schwann_cell	0.15	612.98	Raw ScoresNeurons:Schwann_cell: 0.34, Smooth_muscle_cells:bronchial: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, Tissue_stem_cells:BM_MSC:BMP2: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Tissue_stem_cells:iliac_MSC: 0.26, iPS_cells:adipose_stem_cells: 0.26, Chondrocytes:MSC-derived: 0.26, Fibroblasts:breast: 0.26, Fibroblasts:foreskin: 0.26
T19_CCAGCGACATCGGTTA.1	Neurons:Schwann_cell	0.13	605.70	Raw ScoresNeurons:Schwann_cell: 0.35, Smooth_muscle_cells:bronchial: 0.29, Smooth_muscle_cells:bronchial:vit_D: 0.29, Fibroblasts:foreskin: 0.29, Tissue_stem_cells:BM_MSC:TGFb3: 0.29, Tissue_stem_cells:iliac_MSC: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28, Chondrocytes:MSC-derived: 0.28, Fibroblasts:breast: 0.28
T19_GATGAGGTCTGCGACG.1	Neurons:Schwann_cell	0.15	598.31	Raw ScoresNeurons:Schwann_cell: 0.36, Fibroblasts:foreskin: 0.29, Fibroblasts:breast: 0.29, iPS_cells:adipose_stem_cells: 0.28, Smooth_muscle_cells:bronchial: 0.28, iPS_cells:foreskin_fibrobasts: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, iPS_cells:CRL2097_foreskin: 0.28, iPS_cells:skin_fibroblast: 0.28
T19_ACTGATGGTCTAGCGC.1	Neurons:Schwann_cell	0.13	574.97	Raw ScoresNeurons:Schwann_cell: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Smooth_muscle_cells:bronchial: 0.26, iPS_cells:adipose_stem_cells: 0.26, Chondrocytes:MSC-derived: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Tissue_stem_cells:iliac_MSC: 0.26, Fibroblasts:breast: 0.26, Osteoblasts: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26
T19_AAAGATGTCACGGTTA.1	Macrophage:monocyte-derived:IL-4/Dex/TGFb	0.08	572.53	Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.35, Monocyte:leukotriene_D4: 0.34, Monocyte: 0.34, Monocyte:CD16-: 0.34, Monocyte:anti-FcgRIIB: 0.34, Monocyte:CD14+: 0.34, DC:monocyte-derived:AEC-conditioned: 0.33, Macrophage:monocyte-derived:M-CSF/IFNg: 0.33, Macrophage:monocyte-derived:IL-4/Dex/TGFb: 0.33, DC:monocyte-derived:anti-DC-SIGN_2h: 0.33
T19_GATCGATGTTCACGGC.1	Neurons:Schwann_cell	0.13	569.82	Raw ScoresNeurons:Schwann_cell: 0.35, Smooth_muscle_cells:bronchial: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, Fibroblasts:foreskin: 0.28, Fibroblasts:breast: 0.27, iPS_cells:adipose_stem_cells: 0.27, Tissue_stem_cells:iliac_MSC: 0.27, Tissue_stem_cells:BM_MSC:BMP2: 0.27, iPS_cells:CRL2097_foreskin: 0.27, Tissue_stem_cells:BM_MSC:TGFb3: 0.27
T19_ATTGGACAGTACGTAA.1	Neurons:Schwann_cell	0.13	557.90	Raw ScoresNeurons:Schwann_cell: 0.32, Smooth_muscle_cells:bronchial: 0.25, Smooth_muscle_cells:bronchial:vit_D: 0.25, Fibroblasts:foreskin: 0.24, Fibroblasts:breast: 0.24, iPS_cells:adipose_stem_cells: 0.24, Tissue_stem_cells:BM_MSC:TGFb3: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Tissue_stem_cells:iliac_MSC: 0.24, Tissue_stem_cells:BM_MSC:BMP2: 0.24
T19_TGCACCTTCAAGAAGT.1	Neurons:Schwann_cell	0.11	545.07	Raw ScoresNeurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial: 0.33, Tissue_stem_cells:BM_MSC:BMP2: 0.32, Smooth_muscle_cells:bronchial:vit_D: 0.32, Fibroblasts:foreskin: 0.32, iPS_cells:adipose_stem_cells: 0.32, Fibroblasts:breast: 0.32, Tissue_stem_cells:BM_MSC:TGFb3: 0.31, Chondrocytes:MSC-derived: 0.31, Osteoblasts: 0.31
T19_CTAGTGAAGAAACGCC.1	Neurons:Schwann_cell	0.13	543.75	Raw ScoresNeurons:Schwann_cell: 0.34, Tissue_stem_cells:BM_MSC:BMP2: 0.28, Smooth_muscle_cells:bronchial: 0.28, Fibroblasts:breast: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, Chondrocytes:MSC-derived: 0.27, Fibroblasts:foreskin: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, iPS_cells:adipose_stem_cells: 0.27, Tissue_stem_cells:BM_MSC: 0.27
T19_AGATTGCCAGTAAGAT.1	Neurons:Schwann_cell	0.16	542.38	Raw ScoresNeurons:Schwann_cell: 0.39, Smooth_muscle_cells:bronchial: 0.36, Fibroblasts:breast: 0.36, Smooth_muscle_cells:bronchial:vit_D: 0.36, iPS_cells:adipose_stem_cells: 0.36, Chondrocytes:MSC-derived: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Smooth_muscle_cells:vascular: 0.35, Osteoblasts: 0.35, iPS_cells:fibroblasts: 0.34
T19_TGGCTGGCACCACCAG.1	Neurons:Schwann_cell	0.15	540.46	Raw ScoresNeurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial: 0.3, Smooth_muscle_cells:bronchial:vit_D: 0.29, Fibroblasts:breast: 0.29, iPS_cells:adipose_stem_cells: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.29, Fibroblasts:foreskin: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, iPS_cells:foreskin_fibrobasts: 0.28, Astrocyte:Embryonic_stem_cell-derived: 0.28
T19_GTCCTCACAGTATGCT.1	Neurons:Schwann_cell	0.15	538.04	Raw ScoresNeurons:Schwann_cell: 0.38, Smooth_muscle_cells:bronchial: 0.31, Tissue_stem_cells:BM_MSC:BMP2: 0.31, Smooth_muscle_cells:bronchial:vit_D: 0.31, Tissue_stem_cells:BM_MSC:TGFb3: 0.3, Fibroblasts:foreskin: 0.3, Fibroblasts:breast: 0.3, iPS_cells:adipose_stem_cells: 0.3, Chondrocytes:MSC-derived: 0.3, iPS_cells:foreskin_fibrobasts: 0.29
T19_GCGACCACATCCAACA.1	Neurons:Schwann_cell	0.14	508.41	Raw ScoresNeurons:Schwann_cell: 0.38, Fibroblasts:breast: 0.36, Smooth_muscle_cells:bronchial: 0.36, iPS_cells:adipose_stem_cells: 0.36, Smooth_muscle_cells:bronchial:vit_D: 0.35, Tissue_stem_cells:BM_MSC:TGFb3: 0.35, Tissue_stem_cells:iliac_MSC: 0.35, Tissue_stem_cells:BM_MSC:BMP2: 0.35, Smooth_muscle_cells:vascular: 0.35, Osteoblasts: 0.35
T19_AGAATAGCAGCGATCC.1	Neurons:Schwann_cell	0.12	508.30	Raw ScoresNeurons:Schwann_cell: 0.32, Fibroblasts:foreskin: 0.27, Smooth_muscle_cells:bronchial: 0.27, iPS_cells:adipose_stem_cells: 0.26, Fibroblasts:breast: 0.26, Endothelial_cells:HUVEC:IFNg: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Astrocyte:Embryonic_stem_cell-derived: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26
T19_TCTCTAAAGTACGATA.1	Neurons:Schwann_cell	0.13	500.41	Raw ScoresNeurons:Schwann_cell: 0.33, Fibroblasts:foreskin: 0.27, Fibroblasts:breast: 0.27, Smooth_muscle_cells:bronchial: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, iPS_cells:adipose_stem_cells: 0.26, iPS_cells:foreskin_fibrobasts: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Chondrocytes:MSC-derived: 0.26
T19_CTAGTGAAGGCATTGG.1	Monocyte:leukotriene_D4	0.11	490.10	Raw ScoresMacrophage:monocyte-derived:M-CSF: 0.37, Monocyte:anti-FcgRIIB: 0.37, Monocyte:leukotriene_D4: 0.37, DC:monocyte-derived:AEC-conditioned: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg: 0.36, Macrophage:monocyte-derived:M-CSF/IFNg/Pam3Cys: 0.36, Macrophage:monocyte-derived:IFNa: 0.36, Macrophage:monocyte-derived:S._aureus: 0.36, Monocyte: 0.36, Monocyte:CD16-: 0.36
T19_CGAGAAGGTTATGCGT.1	Neurons:Schwann_cell	0.11	488.65	Raw ScoresNeurons:Schwann_cell: 0.34, Fibroblasts:foreskin: 0.3, Endothelial_cells:HUVEC:IFNg: 0.29, Smooth_muscle_cells:bronchial: 0.28, Endothelial_cells:HUVEC:PR8-infected: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, DC:monocyte-derived:mature: 0.28, Tissue_stem_cells:BM_MSC:BMP2: 0.28, iPS_cells:adipose_stem_cells: 0.28, Endothelial_cells:lymphatic:TNFa_48h: 0.28
T19_ATCACGAAGCTGAAAT.1	Neurons:Schwann_cell	0.13	478.63	Raw ScoresNeurons:Schwann_cell: 0.32, Fibroblasts:breast: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, iPS_cells:adipose_stem_cells: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Smooth_muscle_cells:bronchial: 0.26, Fibroblasts:foreskin: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.25, Tissue_stem_cells:iliac_MSC: 0.25, Chondrocytes:MSC-derived: 0.25
T19_GCCAAATGTCCGTGAC.1	Neurons:Schwann_cell	0.16	477.12	Raw ScoresNeurons:Schwann_cell: 0.37, Smooth_muscle_cells:bronchial: 0.37, Fibroblasts:breast: 0.37, Smooth_muscle_cells:bronchial:vit_D: 0.37, iPS_cells:adipose_stem_cells: 0.36, Chondrocytes:MSC-derived: 0.36, Osteoblasts: 0.36, Tissue_stem_cells:BM_MSC:BMP2: 0.36, Tissue_stem_cells:BM_MSC:TGFb3: 0.35, Tissue_stem_cells:iliac_MSC: 0.35
T19_GTTCTCGCAAGGACTG.1	Neurons:Schwann_cell	0.13	473.61	Raw ScoresNeurons:Schwann_cell: 0.32, Fibroblasts:breast: 0.25, iPS_cells:adipose_stem_cells: 0.25, Tissue_stem_cells:BM_MSC:TGFb3: 0.25, Smooth_muscle_cells:bronchial: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.24, Tissue_stem_cells:BM_MSC: 0.24, Tissue_stem_cells:BM_MSC:BMP2: 0.24, Chondrocytes:MSC-derived: 0.24, Fibroblasts:foreskin: 0.24
T19_CCAATCCCAAGCGTAG.1	Neurons:Schwann_cell	0.11	471.81	Raw ScoresNeurons:Schwann_cell: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.27, Fibroblasts:foreskin: 0.27, iPS_cells:adipose_stem_cells: 0.26, Chondrocytes:MSC-derived: 0.26, Fibroblasts:breast: 0.26, Endothelial_cells:HUVEC:IFNg: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Smooth_muscle_cells:bronchial: 0.26
T19_CTCTACGCATTCTTAC.1	Neurons:Schwann_cell	0.11	469.71	Raw ScoresNeurons:Schwann_cell: 0.31, Fibroblasts:foreskin: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.23, Smooth_muscle_cells:bronchial: 0.23, Endothelial_cells:HUVEC:IFNg: 0.23, Fibroblasts:breast: 0.23, iPS_cells:adipose_stem_cells: 0.23, Smooth_muscle_cells:bronchial:vit_D: 0.23, Tissue_stem_cells:BM_MSC:TGFb3: 0.23, Tissue_stem_cells:BM_MSC:BMP2: 0.23
T19_CGTCTACGTACAGCAG.1	Neurons:Schwann_cell	0.13	467.14	Raw ScoresNeurons:Schwann_cell: 0.32, Smooth_muscle_cells:bronchial: 0.24, Fibroblasts:breast: 0.24, Tissue_stem_cells:BM_MSC:BMP2: 0.24, iPS_cells:adipose_stem_cells: 0.24, Astrocyte:Embryonic_stem_cell-derived: 0.24, Smooth_muscle_cells:bronchial:vit_D: 0.24, Tissue_stem_cells:BM_MSC:TGFb3: 0.24, Endothelial_cells:HUVEC:IFNg: 0.24, Tissue_stem_cells:iliac_MSC: 0.24
T19_CAAGGCCGTCACCTAA.1	Neurons:Schwann_cell	0.13	465.52	Raw ScoresNeurons:Schwann_cell: 0.33, Astrocyte:Embryonic_stem_cell-derived: 0.26, Fibroblasts:foreskin: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Tissue_stem_cells:BM_MSC:TGFb3: 0.26, Smooth_muscle_cells:bronchial: 0.26, Fibroblasts:breast: 0.25, Smooth_muscle_cells:bronchial:vit_D: 0.25, Chondrocytes:MSC-derived: 0.25, Tissue_stem_cells:iliac_MSC: 0.25
T19_CGAGCCACAGCTTAAC.1	Neurons:Schwann_cell	0.12	463.71	Raw ScoresNeurons:Schwann_cell: 0.31, Smooth_muscle_cells:bronchial: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26, Tissue_stem_cells:BM_MSC:BMP2: 0.26, Fibroblasts:breast: 0.25, Tissue_stem_cells:BM_MSC:TGFb3: 0.25, Fibroblasts:foreskin: 0.25, Tissue_stem_cells:iliac_MSC: 0.25, iPS_cells:adipose_stem_cells: 0.25, Astrocyte:Embryonic_stem_cell-derived: 0.25
T19_CGAGCCAAGCCAGGAT.1	Neurons:Schwann_cell	0.12	451.07	Raw ScoresNeurons:Schwann_cell: 0.33, Smooth_muscle_cells:bronchial: 0.27, Astrocyte:Embryonic_stem_cell-derived: 0.27, Smooth_muscle_cells:bronchial:vit_D: 0.27, Fibroblasts:breast: 0.27, Tissue_stem_cells:iliac_MSC: 0.26, Fibroblasts:foreskin: 0.26, iPS_cells:adipose_stem_cells: 0.26, iPS_cells:foreskin_fibrobasts: 0.26, Endothelial_cells:HUVEC:IFNg: 0.26
T19_TCTCTAACACATGTGT.1	Neurons:Schwann_cell	0.13	445.75	Raw ScoresNeurons:Schwann_cell: 0.32, Astrocyte:Embryonic_stem_cell-derived: 0.26, Smooth_muscle_cells:bronchial: 0.25, Smooth_muscle_cells:bronchial:vit_D: 0.25, Fibroblasts:breast: 0.25, Chondrocytes:MSC-derived: 0.24, Fibroblasts:foreskin: 0.24, Tissue_stem_cells:BM_MSC:TGFb3: 0.24, iPS_cells:adipose_stem_cells: 0.24, Tissue_stem_cells:BM_MSC: 0.24
T19_AAGCCGCAGGCGATAC.1	Neurons:Schwann_cell	0.13	445.01	Raw ScoresNeurons:Schwann_cell: 0.31, Smooth_muscle_cells:bronchial: 0.26, Smooth_muscle_cells:bronchial:vit_D: 0.26, Fibroblasts:foreskin: 0.26, Fibroblasts:breast: 0.25, Tissue_stem_cells:BM_MSC:BMP2: 0.25, iPS_cells:adipose_stem_cells: 0.24, Tissue_stem_cells:BM_MSC:TGFb3: 0.24, iPS_cells:foreskin_fibrobasts: 0.24, Tissue_stem_cells:iliac_MSC: 0.24
T19_GGACGTCGTACCTACA.1	Neurons:Schwann_cell	0.14	442.89	Raw ScoresNeurons:Schwann_cell: 0.36, Smooth_muscle_cells:bronchial: 0.29, Fibroblasts:foreskin: 0.29, Tissue_stem_cells:BM_MSC:BMP2: 0.28, Smooth_muscle_cells:bronchial:vit_D: 0.28, Fibroblasts:breast: 0.28, iPS_cells:adipose_stem_cells: 0.28, iPS_cells:foreskin_fibrobasts: 0.28, Tissue_stem_cells:BM_MSC:TGFb3: 0.28, iPS_cells:CRL2097_foreskin: 0.28

Below shows the significant enrichments of this GEP for literature curated gene lists
This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

SCPs mouse and neuroblastoma (Olsen)
Similar to above, but for genes common to neuroblastoma SCP-like cells (as determined from their UMAP plot) and mouse SCP cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-09
Mean rank of genes in gene set: 134.55
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100B	0.0259059	1	GTEx	DepMap	Descartes	21.89	9074.86
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
LGI4	0.0220981	3	GTEx	DepMap	Descartes	2.78	437.06
FXYD1	0.0218314	4	GTEx	DepMap	Descartes	3.71	1797.47
SEMA3B	0.0213777	5	GTEx	DepMap	Descartes	3.61	511.41
GPM6B	0.0193109	10	GTEx	DepMap	Descartes	4.63	521.26
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27
CNN3	0.0084416	54	GTEx	DepMap	Descartes	3.31	663.27
NRXN1	0.0046309	147	GTEx	DepMap	Descartes	2.20	105.92
DST	0.0007515	1210	GTEx	DepMap	Descartes	1.81	26.87

Schwann cell Precursor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the SCP subcluster, which is part of the Adrenal Medulla cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.98e-08
Mean rank of genes in gene set: 458.27
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27
TTYH1	0.0116816	30	GTEx	DepMap	Descartes	0.85	95.20
CHL1	0.0083947	55	GTEx	DepMap	Descartes	1.12	63.87
NGFR	0.0080208	58	GTEx	DepMap	Descartes	1.20	129.85
CNP	0.0068866	77	GTEx	DepMap	Descartes	1.71	139.66
CST3	0.0041104	172	GTEx	DepMap	Descartes	18.54	1771.14
PTPRZ1	0.0034294	224	GTEx	DepMap	Descartes	0.27	12.74
SERPINE2	0.0016862	507	GTEx	DepMap	Descartes	0.93	56.85
LMO4	0.0007937	1143	GTEx	DepMap	Descartes	0.89	53.81
DAGLA	0.0002456	2750	GTEx	DepMap	Descartes	0.06	3.25

SCPs neuroblastoma unique (Olsen)
Similar to above, but for genes unique to neuroblastoma SCP-like cells. Note FN1 is often used as a mesenchymal marker gene.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.32e-05
Mean rank of genes in gene set: 252.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB8	0.0208961	7	GTEx	DepMap	Descartes	2.60	134.09
IFITM3	0.0126861	24	GTEx	DepMap	Descartes	20.43	11724.91
TIMP3	0.0089899	49	GTEx	DepMap	Descartes	3.69	295.24
GFRA3	0.0064768	86	GTEx	DepMap	Descartes	1.50	332.45
ANXA1	0.0047934	139	GTEx	DepMap	Descartes	5.58	1043.81
FN1	0.0007530	1209	GTEx	DepMap	Descartes	3.35	123.95

Schwann cell precursor Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454). These genes were used to show cells transitioning from a SCP to a symphathoblast state in their human fetal single-cell RNA-seq data.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.12e-05
Mean rank of genes in gene set: 1876.1
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100B	0.0259059	1	GTEx	DepMap	Descartes	21.89	9074.86
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27
MOXD1	0.0106558	37	GTEx	DepMap	Descartes	0.21	33.44
MBP	0.0080722	57	GTEx	DepMap	Descartes	1.49	58.57
NGFR	0.0080208	58	GTEx	DepMap	Descartes	1.20	129.85
GAS7	0.0053815	121	GTEx	DepMap	Descartes	0.86	37.77
COL2A1	-0.0001047	7708	GTEx	DepMap	Descartes	0.01	0.72
POSTN	-0.0002750	10733	GTEx	DepMap	Descartes	0.14	7.49

IFN Response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this program contained interferon response genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.22e-04
Mean rank of genes in gene set: 585.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IFIT3	0.0055166	115	GTEx	DepMap	Descartes	1.57	252.96
ISG15	0.0046581	146	GTEx	DepMap	Descartes	11.78	5405.57
IFIT1	0.0043331	163	GTEx	DepMap	Descartes	1.48	126.28
IFIT2	0.0030750	252	GTEx	DepMap	Descartes	0.71	79.90
ISG20	0.0003477	2251	GTEx	DepMap	Descartes	0.57	36.27

Bridge region SCP-like (Olsen)
As above but for the SCP-like region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.72e-04
Mean rank of genes in gene set: 12.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100B	0.0259059	1	GTEx	DepMap	Descartes	21.89	9074.86
FXYD1	0.0218314	4	GTEx	DepMap	Descartes	3.71	1797.47
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27

EMT II (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in HNSCC cell lines:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.08e-04
Mean rank of genes in gene set: 564.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VIM	0.0075168	67	GTEx	DepMap	Descartes	26.71	3434.20
AXL	0.0021069	397	GTEx	DepMap	Descartes	0.58	34.18
COL5A1	0.0014688	585	GTEx	DepMap	Descartes	0.54	21.92
FN1	0.0007530	1209	GTEx	DepMap	Descartes	3.35	123.95

Schwann cell precursor (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being characteristic of Schwann cell lineage and Furlan et al. (Science 2017, PMID 28684471) is referenced to support this. These cell types seem to be claimed to form a bridge between the mesenchymal and adrenergic cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.37e-03
Mean rank of genes in gene set: 8.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100B	0.0259059	1	GTEx	DepMap	Descartes	21.89	9074.86
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27

Schwann cell precursor-like Fig 1D (Olsen)
Similar to above, but for selected SCP marker genes.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.37e-03
Mean rank of genes in gene set: 8.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100B	0.0259059	1	GTEx	DepMap	Descartes	21.89	9074.86
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27

Schwann cell precursor (Kildisiute)
SCP markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.38e-03
Mean rank of genes in gene set: 15.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27

Schwann cell precursors (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.38e-03
Mean rank of genes in gene set: 15.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27

Bridge region mesenchymal-SCP transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.50e-03
Mean rank of genes in gene set: 70
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IFITM3	0.0126861	24	GTEx	DepMap	Descartes	20.43	11724.91
S100A10	0.0069722	74	GTEx	DepMap	Descartes	8.19	5053.39
B2M	0.0056256	112	GTEx	DepMap	Descartes	98.10	14686.51

Mesenchymal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.54e-03
Mean rank of genes in gene set: 916.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VIM	0.0075168	67	GTEx	DepMap	Descartes	26.71	3434.20
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
COL3A1	0.0013487	647	GTEx	DepMap	Descartes	2.98	184.36
COL6A1	0.0002829	2532	GTEx	DepMap	Descartes	1.34	77.70

Proteasomal degradation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this is for proteasomal degradataion:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.43e-03
Mean rank of genes in gene set: 1895.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PSME2	0.0017024	500	GTEx	DepMap	Descartes	2.12	236.17
PSMA4	0.0007690	1177	GTEx	DepMap	Descartes	1.24	95.07
PSMA3	0.0004402	1889	GTEx	DepMap	Descartes	0.73	173.58
PSMC2	0.0002980	2446	GTEx	DepMap	Descartes	0.45	41.14
PSMB3	0.0001501	3467	GTEx	DepMap	Descartes	1.47	559.28

Myelination (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are state as being involved in Myelination and are expressed in the Schwann cell precursor cluster of their UMAP (Fig. 1D), these are suggested to represent more mature myelinating Schwann cells. MPZ is Myelin Protien Zero.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.24e-03
Mean rank of genes in gene set: 12
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LGI4	0.0220981	3	GTEx	DepMap	Descartes	2.78	437.06
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50

Neuroblastoma SCPs but not normal SCPs (Olsen)
The same as above:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.52e-03
Mean rank of genes in gene set: 46.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB8	0.0208961	7	GTEx	DepMap	Descartes	2.6	134.09
GFRA3	0.0064768	86	GTEx	DepMap	Descartes	1.5	332.45

Stress response (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.69e-03
Mean rank of genes in gene set: 1300.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
JUN	0.0009216	973	GTEx	DepMap	Descartes	9.04	793.13
FOS	0.0006543	1374	GTEx	DepMap	Descartes	16.11	1981.48
JUNB	0.0005679	1555	GTEx	DepMap	Descartes	10.36	1471.09

Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.49e-02
Mean rank of genes in gene set: 4702.92
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDPN	0.0079050	59	GTEx	DepMap	Descartes	0.39	60.84
IGFBP6	0.0032814	231	GTEx	DepMap	Descartes	2.85	923.57
CXCL14	0.0031243	247	GTEx	DepMap	Descartes	0.32	42.57
SERPING1	0.0027178	293	GTEx	DepMap	Descartes	1.77	273.81
CCL2	0.0023567	349	GTEx	DepMap	Descartes	8.86	2378.45
CFB	0.0021206	390	GTEx	DepMap	Descartes	0.07	8.58
PDGFRB	0.0005216	1666	GTEx	DepMap	Descartes	0.46	23.53
SCARA3	0.0005118	1692	GTEx	DepMap	Descartes	0.07	8.39
PDGFD	0.0001831	3185	GTEx	DepMap	Descartes	0.04	3.01
LIF	0.0001663	3316	GTEx	DepMap	Descartes	0.06	2.64
IL1R1	0.0001648	3323	GTEx	DepMap	Descartes	0.04	2.01
IL10	0.0001369	3631	GTEx	DepMap	Descartes	0.23	20.97
CXCL12	0.0001085	3910	GTEx	DepMap	Descartes	0.66	51.24
GPX3	0.0000610	4414	GTEx	DepMap	Descartes	0.52	75.36
C3	0.0000525	4523	GTEx	DepMap	Descartes	0.72	41.78
SOD2	0.0000386	4678	GTEx	DepMap	Descartes	1.37	21.12
IGF1	-0.0000486	6349	GTEx	DepMap	Descartes	0.70	28.71
IL33	-0.0001322	8339	GTEx	DepMap	Descartes	0.02	1.00
RGMA	-0.0001472	8654	GTEx	DepMap	Descartes	0.06	1.37
C7	-0.0001482	8676	GTEx	DepMap	Descartes	0.22	11.50
SCARA5	-0.0001538	8807	GTEx	DepMap	Descartes	0.07	4.35
CFD	-0.0001654	9017	GTEx	DepMap	Descartes	0.57	72.37
HGF	-0.0001855	9407	GTEx	DepMap	Descartes	0.12	4.12
PDGFRA	-0.0003140	11099	GTEx	DepMap	Descartes	0.11	4.24
CXCL2	-0.0003420	11318	GTEx	DepMap	Descartes	1.31	196.85

Protein maturation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.89e-02
Mean rank of genes in gene set: 1933.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDIA3	0.0011095	795	GTEx	DepMap	Descartes	1.41	125.07
OS9	0.0005752	1535	GTEx	DepMap	Descartes	0.77	64.98
RPN2	0.0001495	3470	GTEx	DepMap	Descartes	0.96	108.44

Stress response (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.12e-02
Mean rank of genes in gene set: 2986.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DDIT3	0.0016168	528	GTEx	DepMap	Descartes	1.57	455.80
SQSTM1	0.0014288	604	GTEx	DepMap	Descartes	1.58	186.84
ATF3	0.0004595	1842	GTEx	DepMap	Descartes	2.31	268.76
GADD45B	0.0003881	2078	GTEx	DepMap	Descartes	3.02	387.56
GADD45A	-0.0002117	9882	GTEx	DepMap	Descartes	0.49	77.51

Stroma (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Stroma cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.25e-02
Mean rank of genes in gene set: 3026.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL5A1	0.0014688	585	GTEx	DepMap	Descartes	0.54	21.92
COL3A1	0.0013487	647	GTEx	DepMap	Descartes	2.98	184.36
FN1	0.0007530	1209	GTEx	DepMap	Descartes	3.35	123.95
COL6A1	0.0002829	2532	GTEx	DepMap	Descartes	1.34	77.70
GPC3	-0.0002306	10161	GTEx	DepMap	Descartes	0.33	39.59

p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.29e-02
Mean rank of genes in gene set: 1563
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0012445	696	GTEx	DepMap	Descartes	5.91	66.75
CDKN1A	0.0003018	2430	GTEx	DepMap	Descartes	0.83	84.67

Schwann cell precursors (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-02
Mean rank of genes in gene set: 2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76

Schwann cell precursors (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. The authors data suggest these SCPs can give rise to symphathoblasts, which can then give rise to chromaffin cells. However, these SCPs can also directly give rise to chromaffin cells (i.e there are two bridges/paths).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.17e-02
Mean rank of genes in gene set: 2
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76

Axon guidance (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for axon guidance instead of myelination:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.18e-02
Mean rank of genes in gene set: 5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SEMA3B	0.0213777	5	GTEx	DepMap	Descartes	3.61	511.41

Stromal 2 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.18e-02
Mean rank of genes in gene set: 4665.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL14A1	0.0165330	13	GTEx	DepMap	Descartes	1.46	85.43
PENK	0.0042416	167	GTEx	DepMap	Descartes	0.37	83.03
FSTL1	0.0022549	364	GTEx	DepMap	Descartes	1.04	59.62
COL5A2	0.0019056	449	GTEx	DepMap	Descartes	0.75	34.38
GSN	0.0013953	622	GTEx	DepMap	Descartes	5.77	275.89
FBN1	0.0005164	1679	GTEx	DepMap	Descartes	0.27	7.20
FBN2	-0.0000324	5915	GTEx	DepMap	Descartes	0.06	1.10
ITM2A	-0.0000455	6261	GTEx	DepMap	Descartes	0.20	37.32
SFRP1	-0.0001454	8611	GTEx	DepMap	Descartes	0.36	27.93
GAS1	-0.0001498	8717	GTEx	DepMap	Descartes	0.03	3.82
POSTN	-0.0002750	10733	GTEx	DepMap	Descartes	0.14	7.49
IGFBP5	-0.0008682	12455	GTEx	DepMap	Descartes	9.14	366.38

Adrenergic neuroblatoma (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - neuroblastoma adrenergic markers derived from their data, which are state as resembling sympathoblasts and lacking chromffin markers such as PNMT:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.84e-02
Mean rank of genes in gene set: 886
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71

Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.38e-02
Mean rank of genes in gene set: 5594.51
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL14A1	0.0165330	13	GTEx	DepMap	Descartes	1.46	85.43
CNN3	0.0084416	54	GTEx	DepMap	Descartes	3.31	663.27
THBS2	0.0042529	165	GTEx	DepMap	Descartes	0.54	34.41
ITGA7	0.0040795	176	GTEx	DepMap	Descartes	0.25	22.77
TGFBR2	0.0025057	322	GTEx	DepMap	Descartes	0.77	48.20
COL8A1	0.0025053	323	GTEx	DepMap	Descartes	0.82	49.99
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
COL5A2	0.0019056	449	GTEx	DepMap	Descartes	0.75	34.38
MYL9	0.0018447	467	GTEx	DepMap	Descartes	2.43	246.39
COL12A1	0.0016814	508	GTEx	DepMap	Descartes	0.37	10.77
COL5A1	0.0014688	585	GTEx	DepMap	Descartes	0.54	21.92
THBS1	0.0013863	628	GTEx	DepMap	Descartes	0.74	28.19
COL3A1	0.0013487	647	GTEx	DepMap	Descartes	2.98	184.36
COL4A1	0.0011648	753	GTEx	DepMap	Descartes	1.85	90.96
TNC	0.0009757	918	GTEx	DepMap	Descartes	0.50	14.34
COL15A1	0.0008138	1113	GTEx	DepMap	Descartes	0.57	33.27
FN1	0.0007530	1209	GTEx	DepMap	Descartes	3.35	123.95
MEF2C	0.0005161	1681	GTEx	DepMap	Descartes	0.73	29.46
TPM2	0.0004664	1814	GTEx	DepMap	Descartes	1.60	260.95
MMP11	0.0004012	2027	GTEx	DepMap	Descartes	0.06	5.43
MYH11	0.0002064	3013	GTEx	DepMap	Descartes	0.24	7.18
IGFBP7	0.0000682	4338	GTEx	DepMap	Descartes	21.24	4026.09
ACTA2	0.0000570	4467	GTEx	DepMap	Descartes	1.20	207.80
COL13A1	0.0000323	4763	GTEx	DepMap	Descartes	0.02	2.36
BGN	-0.0000287	5829	GTEx	DepMap	Descartes	0.59	63.95
COL10A1	-0.0000321	5908	GTEx	DepMap	Descartes	0.00	0.00
TGFBR1	-0.0000741	6958	GTEx	DepMap	Descartes	0.15	7.56
TGFB2	-0.0001114	7859	GTEx	DepMap	Descartes	0.07	2.66
WNT5A	-0.0001261	8195	GTEx	DepMap	Descartes	0.04	0.86
TGFB1	-0.0001278	8240	GTEx	DepMap	Descartes	0.33	32.42
IGFBP3	-0.0001456	8619	GTEx	DepMap	Descartes	0.12	9.27
PGF	-0.0001731	9167	GTEx	DepMap	Descartes	0.28	20.73
MYLK	-0.0001746	9192	GTEx	DepMap	Descartes	0.40	8.49
COL1A1	-0.0001787	9278	GTEx	DepMap	Descartes	4.94	218.80
CNN2	-0.0001943	9583	GTEx	DepMap	Descartes	0.25	27.57
HOPX	-0.0001998	9675	GTEx	DepMap	Descartes	0.19	14.97
TAGLN	-0.0002019	9707	GTEx	DepMap	Descartes	2.93	176.38
ACTG2	-0.0002465	10400	GTEx	DepMap	Descartes	0.28	20.06
MMP2	-0.0002622	10579	GTEx	DepMap	Descartes	0.69	51.10
TMEM119	-0.0002703	10670	GTEx	DepMap	Descartes	0.02	1.85
LUM	-0.0002738	10719	GTEx	DepMap	Descartes	5.28	569.88
POSTN	-0.0002750	10733	GTEx	DepMap	Descartes	0.14	7.49
VEGFA	-0.0003216	11161	GTEx	DepMap	Descartes	0.13	2.14
COL11A1	-0.0003319	11245	GTEx	DepMap	Descartes	0.06	1.86
VCAN	-0.0003356	11266	GTEx	DepMap	Descartes	0.40	9.93
THY1	-0.0004494	11908	GTEx	DepMap	Descartes	0.38	19.82
TPM1	-0.0004575	11938	GTEx	DepMap	Descartes	1.15	70.22
DCN	-0.0004754	12000	GTEx	DepMap	Descartes	5.24	206.90
RGS5	-0.0008439	12449	GTEx	DepMap	Descartes	1.73	59.20

Mesenchymal (Kildisiute)
Mesenchymal markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.02e-01
Mean rank of genes in gene set: 1666
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRB	0.0005216	1666	GTEx	DepMap	Descartes	0.46	23.53

Mesenchymal cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that COL1A1+ Mesenchymal were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.17e-01
Mean rank of genes in gene set: 3788
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
PDGFRB	0.0005216	1666	GTEx	DepMap	Descartes	0.46	23.53
COL1A1	-0.0001787	9278	GTEx	DepMap	Descartes	4.94	218.80

Kidney Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.55e-01
Mean rank of genes in gene set: 2599
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LYPD1	0.0002711	2599	GTEx	DepMap	Descartes	0.27	21.78

Fetal Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Fetal Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.74e-01
Mean rank of genes in gene set: 2875
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GRAMD1B	0.0002245	2875	GTEx	DepMap	Descartes	0.07	2.26

Stromal 1 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.91e-01
Mean rank of genes in gene set: 5079.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP14	0.0023729	346	GTEx	DepMap	Descartes	0.46	43.90
HMGA2	0.0021359	386	GTEx	DepMap	Descartes	0.02	1.27
COL27A1	0.0016951	503	GTEx	DepMap	Descartes	0.09	3.11
NFIB	0.0000734	4273	GTEx	DepMap	Descartes	0.57	18.18
TGFB2	-0.0001114	7859	GTEx	DepMap	Descartes	0.07	2.66
IGSF3	-0.0002228	10040	GTEx	DepMap	Descartes	0.06	2.25
CHD3	-0.0005337	12149	GTEx	DepMap	Descartes	0.22	8.10

Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.14e-01
Mean rank of genes in gene set: 5480
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARC	0.0077700	63	GTEx	DepMap	Descartes	9.14	958.42
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
COL3A1	0.0013487	647	GTEx	DepMap	Descartes	2.98	184.36
COL6A2	0.0007690	1178	GTEx	DepMap	Descartes	2.27	175.12
CALD1	0.0006186	1447	GTEx	DepMap	Descartes	3.48	191.11
LEPR	0.0003514	2233	GTEx	DepMap	Descartes	0.07	1.64
PRRX1	0.0000242	4860	GTEx	DepMap	Descartes	0.23	14.32
BGN	-0.0000287	5829	GTEx	DepMap	Descartes	0.59	63.95
COL1A1	-0.0001787	9278	GTEx	DepMap	Descartes	4.94	218.80
LUM	-0.0002738	10719	GTEx	DepMap	Descartes	5.28	569.88
PDGFRA	-0.0003140	11099	GTEx	DepMap	Descartes	0.11	4.24
MGP	-0.0003652	11467	GTEx	DepMap	Descartes	1.16	211.82
DCN	-0.0004754	12000	GTEx	DepMap	Descartes	5.24	206.90

Bridge region mesencchymal (Olsen)
Marker genes shown in Fig. 3A of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - Cells were ordered by pseudotime in the bridge region, this first group of cells were from the mesenchymal part of the trajectory.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.32e-01
Mean rank of genes in gene set: 5540.15
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
CALD1	0.0006186	1447	GTEx	DepMap	Descartes	3.48	191.11
MAFF	0.0004061	1998	GTEx	DepMap	Descartes	0.54	44.12
KLF4	0.0003355	2297	GTEx	DepMap	Descartes	0.88	69.57
FGF1	0.0002641	2644	GTEx	DepMap	Descartes	0.04	3.24
MYC	0.0000362	4711	GTEx	DepMap	Descartes	0.33	20.58
PRRX1	0.0000242	4860	GTEx	DepMap	Descartes	0.23	14.32
BGN	-0.0000287	5829	GTEx	DepMap	Descartes	0.59	63.95
NPNT	-0.0001066	7753	GTEx	DepMap	Descartes	0.01	0.16
TNNT2	-0.0001357	8418	GTEx	DepMap	Descartes	0.00	0.00
PODXL	-0.0002087	9827	GTEx	DepMap	Descartes	0.05	1.11
LUM	-0.0002738	10719	GTEx	DepMap	Descartes	5.28	569.88
PDGFRA	-0.0003140	11099	GTEx	DepMap	Descartes	0.11	4.24

Noninflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.90e-01
Mean rank of genes in gene set: 4856.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MAF	0.0008072	1127	GTEx	DepMap	Descartes	0.30	15.49
CD163	-0.0001437	8586	GTEx	DepMap	Descartes	0.16	8.03

Nerves and neurofiliment (Olsen)
Markers listed in on page 4 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - NF200 is expressed in neurofiliments and is found close to SCPs in normal tissue, NRG1 is secreted by neurons, to which ERBB3 (on glia) binds.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.13e-01
Mean rank of genes in gene set: 4510
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	5.34e-05	4510	GTEx	DepMap	Descartes	0.08	2.12

Muscle progenitor (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PAX7+ Muscle progenitor were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.33e-01
Mean rank of genes in gene set: 5166
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDON	4.98e-05	4551	GTEx	DepMap	Descartes	0.02	0.66
PAX7	-2.68e-05	5781	GTEx	DepMap	Descartes	0.00	0.00

Mixed phenotype identified at the fate split point mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells. markers are of the split point where SCPs differentiate.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.48e-01
Mean rank of genes in gene set: 4860
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	2.42e-05	4860	GTEx	DepMap	Descartes	0.23	14.32

Myocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that MYH3+ Myocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.57e-01
Mean rank of genes in gene set: 5333.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYH3	0.0001239	3756	GTEx	DepMap	Descartes	0.01	0.13
TTN	-0.0000725	6911	GTEx	DepMap	Descartes	0.00	0.00

Endothelial subclusters 2-6 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Various endothelial subclusters of Endothelium clusters:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.83e-01
Mean rank of genes in gene set: 6033.85
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CLIC4	0.0069724	73	GTEx	DepMap	Descartes	1.17	112.75
FBLN2	0.0020353	416	GTEx	DepMap	Descartes	0.29	22.15
HES1	0.0014551	593	GTEx	DepMap	Descartes	1.25	307.29
FAM102A	0.0014231	609	GTEx	DepMap	Descartes	0.24	24.68
DUSP6	0.0013388	652	GTEx	DepMap	Descartes	0.43	41.76
RHOB	0.0004436	1882	GTEx	DepMap	Descartes	1.78	225.45
ADAMTS1	0.0004232	1944	GTEx	DepMap	Descartes	0.32	14.79
JAG1	0.0001733	3266	GTEx	DepMap	Descartes	0.43	21.90
IVNS1ABP	0.0000631	4385	GTEx	DepMap	Descartes	0.32	25.49
SHROOM2	-0.0000039	5257	GTEx	DepMap	Descartes	0.05	1.39
THBD	-0.0000806	7145	GTEx	DepMap	Descartes	0.22	11.79
LFNG	-0.0001425	8566	GTEx	DepMap	Descartes	0.05	4.71
IGFBP3	-0.0001456	8619	GTEx	DepMap	Descartes	0.12	9.27
MECOM	-0.0001599	8919	GTEx	DepMap	Descartes	0.01	0.10
TM4SF1	-0.0003009	10995	GTEx	DepMap	Descartes	0.56	35.77
GJA1	-0.0003093	11061	GTEx	DepMap	Descartes	0.07	3.92
SPRY1	-0.0003230	11171	GTEx	DepMap	Descartes	0.67	60.89
MCF2L	-0.0003238	11172	GTEx	DepMap	Descartes	0.03	0.49
CDK1	-0.0003599	11438	GTEx	DepMap	Descartes	0.22	8.72
MARCKSL1	-0.0011116	12514	GTEx	DepMap	Descartes	4.07	565.92

Subepicardial mesenchyme (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.87e-01
Mean rank of genes in gene set: 5883.29
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
COL3A1	0.0013487	647	GTEx	DepMap	Descartes	2.98	184.36
TBX18	0.0003664	2171	GTEx	DepMap	Descartes	0.14	5.76
PRRX1	0.0000242	4860	GTEx	DepMap	Descartes	0.23	14.32
COL1A1	-0.0001787	9278	GTEx	DepMap	Descartes	4.94	218.80
TWIST2	-0.0003853	11606	GTEx	DepMap	Descartes	0.08	16.32
TWIST1	-0.0005635	12201	GTEx	DepMap	Descartes	0.36	25.92

Myofibroblasts (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ACTA2+ Myofibroblasts were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.97e-01
Mean rank of genes in gene set: 5729
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYH11	0.0002064	3013	GTEx	DepMap	Descartes	0.24	7.18
ACTA2	0.0000570	4467	GTEx	DepMap	Descartes	1.20	207.80
TAGLN	-0.0002019	9707	GTEx	DepMap	Descartes	2.93	176.38

Stromal 3 (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Stroma subcluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.20e-01
Mean rank of genes in gene set: 5850.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OLFML3	0.0003788	2112	GTEx	DepMap	Descartes	0.99	126.14
NOTCH3	0.0000999	3994	GTEx	DepMap	Descartes	0.28	6.82
PIK3R1	-0.0003612	11445	GTEx	DepMap	Descartes	0.46	18.12

Endothelial Cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.62e-01
Mean rank of genes in gene set: 6030
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ENG	0.0003394	2284	GTEx	DepMap	Descartes	0.41	32.77
VWF	-0.0002058	9776	GTEx	DepMap	Descartes	0.13	1.94

Endothelium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.88e-01
Mean rank of genes in gene set: 6218.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRCP	0.0012268	709	GTEx	DepMap	Descartes	0.43	19.45
EGFL7	-0.0000788	7089	GTEx	DepMap	Descartes	0.10	10.81
KDR	-0.0000857	7260	GTEx	DepMap	Descartes	0.02	0.40
FLT1	-0.0002078	9815	GTEx	DepMap	Descartes	0.01	0.10

Sympathoblasts (Kildisiute)
Sympathoblasts markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.89e-01
Mean rank of genes in gene set: 6217
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71
BCL2	-0.0000095	5362	GTEx	DepMap	Descartes	0.20	10.49
NPY	-0.0007484	12403	GTEx	DepMap	Descartes	5.01	1135.62

Bridge (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.01e-01
Mean rank of genes in gene set: 6278.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDH9	0.0002242	2876	GTEx	DepMap	Descartes	0.01	1.04
CTTNBP2	-0.0001137	7916	GTEx	DepMap	Descartes	0.01	0.20
ERBB4	-0.0001192	8044	GTEx	DepMap	Descartes	0.00	0.00

Erythroid cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.14e-01
Mean rank of genes in gene set: 6400
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALAS2	-5.08e-05	6400	GTEx	DepMap	Descartes	0	0

Immune (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Immune cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.16e-01
Mean rank of genes in gene set: 6374.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TMSB4X	0.0004631	1830	GTEx	DepMap	Descartes	65.56	10638.13
LCP2	-0.0002917	10919	GTEx	DepMap	Descartes	0.14	8.03

EMT III (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was enriched in non-cycling cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.42e-01
Mean rank of genes in gene set: 6467.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2	0.0040187	179	GTEx	DepMap	Descartes	0.18	8.31
LAMA3	-0.0000505	6391	GTEx	DepMap	Descartes	0.00	0.00
LAMB3	-0.0000910	7394	GTEx	DepMap	Descartes	0.01	0.63
JUP	-0.0004492	11906	GTEx	DepMap	Descartes	0.06	4.78

Adrenergic mature (olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These markers are specific to the mature adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.54e-01
Mean rank of genes in gene set: 6625
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71
NTRK1	-0.0007003	12364	GTEx	DepMap	Descartes	0.09	2.94

PMN-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.75e-01
Mean rank of genes in gene set: 6447.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0047934	139	GTEx	DepMap	Descartes	5.58	1043.81
CSF1	0.0025444	315	GTEx	DepMap	Descartes	0.23	23.95
STAT6	0.0008424	1075	GTEx	DepMap	Descartes	0.15	14.20
STAT1	0.0006282	1425	GTEx	DepMap	Descartes	0.94	65.46
IRF1	0.0005539	1587	GTEx	DepMap	Descartes	0.92	46.22
CD84	-0.0000702	6864	GTEx	DepMap	Descartes	0.09	2.60
ARG1	-0.0001042	7695	GTEx	DepMap	Descartes	0.00	0.00
TNFRSF10B	-0.0001137	7917	GTEx	DepMap	Descartes	0.08	3.87
HIF1A	-0.0001204	8065	GTEx	DepMap	Descartes	0.42	25.89
TGFB1	-0.0001278	8240	GTEx	DepMap	Descartes	0.33	32.42
STAT3	-0.0001387	8477	GTEx	DepMap	Descartes	0.90	45.59
SLC27A2	-0.0001701	9109	GTEx	DepMap	Descartes	0.00	0.00
CD36	-0.0001968	9629	GTEx	DepMap	Descartes	0.10	2.15
PTGS2	-0.0002080	9820	GTEx	DepMap	Descartes	0.18	7.29
IL1B	-0.0003248	11182	GTEx	DepMap	Descartes	1.07	136.55
ARG2	-0.0003879	11617	GTEx	DepMap	Descartes	0.09	4.17

Mesencchymal populations mouse (Olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.89e-01
Mean rank of genes in gene set: 6849.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRRX1	2.42e-05	4860	GTEx	DepMap	Descartes	0.23	14.32
FLI1	-1.56e-04	8839	GTEx	DepMap	Descartes	0.05	3.21

Bridge region SCP-adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to SCP-adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.97e-01
Mean rank of genes in gene set: 6717.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MDK	0.0038276	192	GTEx	DepMap	Descartes	9.22	2512.88
SRP14	0.0002391	2796	GTEx	DepMap	Descartes	6.09	1634.50
HMGB1	-0.0003471	11356	GTEx	DepMap	Descartes	6.38	294.39
PCBP2	-0.0011922	12526	GTEx	DepMap	Descartes	1.78	131.42

HSCs and immune cells (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.67e-01
Mean rank of genes in gene set: 7180.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AIF1	-0.0000206	5632	GTEx	DepMap	Descartes	2.43	398.03
RGS10	-0.0000880	7323	GTEx	DepMap	Descartes	1.35	342.47
CD163	-0.0001437	8586	GTEx	DepMap	Descartes	0.16	8.03

Adrenal cortex (Kildisiute)
Adrenal cortex markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.79e-01
Mean rank of genes in gene set: 7962
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-0.000116	7962	GTEx	DepMap	Descartes	0.01	0.41

Adrenal gland cortex (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. :
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.79e-01
Mean rank of genes in gene set: 7962
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STAR	-0.000116	7962	GTEx	DepMap	Descartes	0.01	0.41

Endothelium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the broad Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.87e-01
Mean rank of genes in gene set: 8041
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	-0.0001192	8041	GTEx	DepMap	Descartes	1.45	101.37

Vascular (Kildisiute)
Vascular markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.16e-01
Mean rank of genes in gene set: 7468.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRB	-0.0000505	6390	GTEx	DepMap	Descartes	0.08	0.90
KDR	-0.0000857	7260	GTEx	DepMap	Descartes	0.02	0.40
PLVAP	-0.0001512	8756	GTEx	DepMap	Descartes	0.07	4.47

B cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.30e-01
Mean rank of genes in gene set: 8499
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD79A	-0.0001396	8499	GTEx	DepMap	Descartes	0	0

Liver Primordium (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.38e-01
Mean rank of genes in gene set: 7907
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AHSG	-0.0000643	6711	GTEx	DepMap	Descartes	0.00	0.00
VTN	-0.0001697	9103	GTEx	DepMap	Descartes	0.01	0.43

Mesenchymal (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are stated as being expressed in a group of mesenchymal-like cells (some at least claimed to be neuroblastoma cells) shown in their UMAP representation on Fig. 1D. They reference the two Nature Genetics paper.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.59e-01
Mean rank of genes in gene set: 7548
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LEPR	0.0003514	2233	GTEx	DepMap	Descartes	0.07	1.64
PRRX1	0.0000242	4860	GTEx	DepMap	Descartes	0.23	14.32
PDGFRA	-0.0003140	11099	GTEx	DepMap	Descartes	0.11	4.24
DCN	-0.0004754	12000	GTEx	DepMap	Descartes	5.24	206.90

Endothelial cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRB+ Endothelial cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.62e-01
Mean rank of genes in gene set: 7764.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRB	-0.0000505	6390	GTEx	DepMap	Descartes	0.08	0.90
EGFL7	-0.0000788	7089	GTEx	DepMap	Descartes	0.10	10.81
FLT1	-0.0002078	9815	GTEx	DepMap	Descartes	0.01	0.10

M2 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.64e-01
Mean rank of genes in gene set: 7260.71
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL10	0.0001369	3631	GTEx	DepMap	Descartes	0.23	20.97
IL13	-0.0000232	5699	GTEx	DepMap	Descartes	0.00	0.00
CD14	-0.0000282	5813	GTEx	DepMap	Descartes	1.83	197.54
ARG1	-0.0001042	7695	GTEx	DepMap	Descartes	0.00	0.00
TGFB1	-0.0001278	8240	GTEx	DepMap	Descartes	0.33	32.42
CD163	-0.0001437	8586	GTEx	DepMap	Descartes	0.16	8.03
VEGFA	-0.0003216	11161	GTEx	DepMap	Descartes	0.13	2.14

EMT I melanoma (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, this EMT program was melanoma specific.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.84e-01
Mean rank of genes in gene set: 7918.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RRAS	0.0012724	683	GTEx	DepMap	Descartes	0.41	147.52
CAV1	-0.0003173	11134	GTEx	DepMap	Descartes	0.41	26.50
TPM1	-0.0004575	11938	GTEx	DepMap	Descartes	1.15	70.22

Pigmentation (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, Skin pigmentation genes, identified in melanoma.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.94e-01
Mean rank of genes in gene set: 7761.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MLANA	0.0000193	4930	GTEx	DepMap	Descartes	0.00	0.00
DCT	-0.0000789	7092	GTEx	DepMap	Descartes	0.00	0.00
PMEL	-0.0001573	8868	GTEx	DepMap	Descartes	0.00	0.00
MITF	-0.0002303	10157	GTEx	DepMap	Descartes	0.07	3.44

Meta_8 undefined undifferentiated neuronal (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.97e-01
Mean rank of genes in gene set: 8406
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CTNNB1	0.0000629	4389	GTEx	DepMap	Descartes	0.70	40.65
SOX11	-0.0007878	12423	GTEx	DepMap	Descartes	0.34	6.54

Erythrocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that HBA2+ Erythrocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.02e-01
Mean rank of genes in gene set: 9353
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK1	-0.0001828	9353	GTEx	DepMap	Descartes	0.02	0.26

Chromaffin cells Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for chromaffin cells (differentiating from symphathoblasts):
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.34e-01
Mean rank of genes in gene set: 8306
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0042416	167	GTEx	DepMap	Descartes	0.37	83.03
CHGB	-0.0006090	12276	GTEx	DepMap	Descartes	0.77	44.60
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33

Hepatocytes (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that ALB+ Hepatocytes were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D. The main text also speculated that these hepatocytes were probably derived from neighboring tissue, and hence artifactual, but there is no evidence presented for this.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.36e-01
Mean rank of genes in gene set: 8782
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ALB	-0.0000393	6100	GTEx	DepMap	Descartes	0.00	0.00
ASGR1	-0.0003646	11464	GTEx	DepMap	Descartes	0.03	1.83

M1 Macrophage
These genes were collated from multiple sources:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.44e-01
Mean rank of genes in gene set: 7377.64
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL2	0.0023567	349	GTEx	DepMap	Descartes	8.86	2378.45
CXCL16	0.0011587	757	GTEx	DepMap	Descartes	0.72	89.97
CD14	-0.0000282	5813	GTEx	DepMap	Descartes	1.83	197.54
IL18	-0.0001163	7968	GTEx	DepMap	Descartes	0.22	30.58
CD80	-0.0001279	8242	GTEx	DepMap	Descartes	0.01	0.95
IL33	-0.0001322	8339	GTEx	DepMap	Descartes	0.02	1.00
ITGAX	-0.0001582	8889	GTEx	DepMap	Descartes	0.10	4.63
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08
TNF	-0.0002141	9927	GTEx	DepMap	Descartes	0.30	39.96
TLR4	-0.0002160	9955	GTEx	DepMap	Descartes	0.06	1.13
IL1B	-0.0003248	11182	GTEx	DepMap	Descartes	1.07	136.55

Melanocytes (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.77e-01
Mean rank of genes in gene set: 8705.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DCT	-0.0000789	7092	GTEx	DepMap	Descartes	0.00	0.00
PMEL	-0.0001573	8868	GTEx	DepMap	Descartes	0.00	0.00
MITF	-0.0002303	10157	GTEx	DepMap	Descartes	0.07	3.44

Cytotoxic T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.89e-01
Mean rank of genes in gene set: 10698
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

Normal Schwann cell precurors, but not Neuroblastoma Scps (Olsen)
Based on their neuroblastoma data and stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.91e-01
Mean rank of genes in gene set: 10733
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
POSTN	-0.000275	10733	GTEx	DepMap	Descartes	0.14	7.49

Angioblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for Angioblast subcluster of Endothelium cluster:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.97e-01
Mean rank of genes in gene set: 8915.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PREX1	-0.0000484	6342	GTEx	DepMap	Descartes	0.09	3.50
NES	-0.0001607	8944	GTEx	DepMap	Descartes	0.85	41.27
MAP4K4	-0.0003642	11461	GTEx	DepMap	Descartes	0.53	20.07

Other T cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.02e-01
Mean rank of genes in gene set: 8188.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TCF7	0.0000804	4197	GTEx	DepMap	Descartes	0.19	11.91
LEF1	-0.0000374	6051	GTEx	DepMap	Descartes	0.19	18.40
FOXP3	-0.0000608	6636	GTEx	DepMap	Descartes	0.01	0.24
CD4	-0.0001974	9642	GTEx	DepMap	Descartes	0.21	11.19
CCR7	-0.0003304	11234	GTEx	DepMap	Descartes	0.02	0.95
SELL	-0.0003502	11372	GTEx	DepMap	Descartes	0.12	10.35

Pre-E Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Pre Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.08e-01
Mean rank of genes in gene set: 7660.92
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLE1	0.0021265	389	GTEx	DepMap	Descartes	0.43	43.73
JUN	0.0009216	973	GTEx	DepMap	Descartes	9.04	793.13
ARHGEF28	0.0002397	2791	GTEx	DepMap	Descartes	0.04	NA
SLC38A4	-0.0000199	5614	GTEx	DepMap	Descartes	0.00	0.00
LRP11	-0.0000330	5943	GTEx	DepMap	Descartes	0.04	2.61
ARNT2	-0.0000936	7459	GTEx	DepMap	Descartes	0.06	1.99
SLC31A1	-0.0002786	10768	GTEx	DepMap	Descartes	0.08	4.76
RPS6KA6	-0.0003005	10991	GTEx	DepMap	Descartes	0.02	0.63
FAM163A	-0.0003515	11380	GTEx	DepMap	Descartes	0.01	0.48
PCP4	-0.0003704	11513	GTEx	DepMap	Descartes	0.03	NA
TMX4	-0.0004684	11974	GTEx	DepMap	Descartes	0.35	17.12
NELFCD	-0.0005300	12136	GTEx	DepMap	Descartes	0.35	NA

Mesemchymal validated (Olsen)
Stated on pages 7 and 8 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is stated that a mesenchymal-like neuroblastoma cell state is validate by combined immunofluorescence staining for PDGFRA and FISH for PPMID gain, a gene on 17q.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.09e-01
Mean rank of genes in gene set: 11099
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDGFRA	-0.000314	11099	GTEx	DepMap	Descartes	0.11	4.24

Inflammatory Macrophages (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.16e-01
Mean rank of genes in gene set: 11266
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	-0.0003356	11266	GTEx	DepMap	Descartes	0.4	9.93

Bridge (Kildisiute)
Bridge cell (cites Furlan 2017) markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.33e-01
Mean rank of genes in gene set: 11703
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DLL3	-0.0004047	11703	GTEx	DepMap	Descartes	0.1	5.12

Definitive Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Definitive Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.34e-01
Mean rank of genes in gene set: 8996.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHCHD10	0.0001149	3839	GTEx	DepMap	Descartes	1.14	260.38
CALN1	-0.0001517	8764	GTEx	DepMap	Descartes	0.00	0.00
GREB1	-0.0002953	10950	GTEx	DepMap	Descartes	0.02	0.54
CPE	-0.0008049	12433	GTEx	DepMap	Descartes	0.65	47.26

Leukocyte (Kildisiute)
Leukocyes markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.39e-01
Mean rank of genes in gene set: 11864
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.0004392	11864	GTEx	DepMap	Descartes	0.3	9.61

Antigen Presenting CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain antigen presenting specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.41e-01
Mean rank of genes in gene set: 7910.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A10	0.0069722	74	GTEx	DepMap	Descartes	8.19	5053.39
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74
S100A13	0.0020242	417	GTEx	DepMap	Descartes	1.01	130.94
UPK3B	-0.0001572	8866	GTEx	DepMap	Descartes	0.00	0.00
S100A3	-0.0001689	9084	GTEx	DepMap	Descartes	0.02	6.54
S100A4	-0.0001989	9662	GTEx	DepMap	Descartes	3.29	1097.78
SLPI	-0.0002026	9718	GTEx	DepMap	Descartes	0.01	6.96
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08
KRT18	-0.0003445	11340	GTEx	DepMap	Descartes	0.02	1.80
CD83	-0.0003651	11466	GTEx	DepMap	Descartes	0.96	77.69
KRT8	-0.0004162	11765	GTEx	DepMap	Descartes	0.04	2.98
KRT19	-0.0008409	12444	GTEx	DepMap	Descartes	0.41	35.76

EpiSen (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers, an epithelial senescence associated program.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.47e-01
Mean rank of genes in gene set: 9202.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AQP3	-0.0000966	7525	GTEx	DepMap	Descartes	0.02	4.38
LCN2	-0.0001543	8812	GTEx	DepMap	Descartes	0.00	0.00
SLPI	-0.0002026	9718	GTEx	DepMap	Descartes	0.01	6.96
CLDN4	-0.0002775	10755	GTEx	DepMap	Descartes	0.01	0.27

Adrenergic immature (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These is a marker listed for the immature adrenergic cells. SOX11 is referenced as important in early phases of pro-adrenergic differentiation (cites PMID 20147379) whereas SOX4 appears later. SOX11 is also associated with poor outcome in neuroblatoma bulk RNA-seq data (Olsen analysis).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.55e-01
Mean rank of genes in gene set: 12423
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOX11	-0.0007878	12423	GTEx	DepMap	Descartes	0.34	6.54

Symphathoadrenal cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 12475
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33

Immune cells (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that PTPRC+ Immune cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 11346
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD247	-0.0002839	10828	GTEx	DepMap	Descartes	0.01	0.19
PTPRC	-0.0004392	11864	GTEx	DepMap	Descartes	0.30	9.61

Cell cycle (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.76e-01
Mean rank of genes in gene set: 10415.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PCNA	-0.0001283	8249	GTEx	DepMap	Descartes	0.30	62.43
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 9967.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TPI1	0.0001592	3379	GTEx	DepMap	Descartes	3.42	516.94
TK1	-0.0003847	11603	GTEx	DepMap	Descartes	0.27	19.05
MIF	-0.0007054	12368	GTEx	DepMap	Descartes	1.64	432.61
NPM1	-0.0011450	12521	GTEx	DepMap	Descartes	4.43	572.37

Adrenergic proliferating cluster (Olsen)
Stated on pages 6 and 7 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - it is argued that upon reanalysis of the adrenergic neuroblastoma cells, there is further heterogeneity, grouped into proliferating, mature and immature cell populations. These genes were found as markers for proliferating adrenergic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 11501
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
EZH2	-0.0003786	11560	GTEx	DepMap	Descartes	0.10	6.08

Late Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: the Jansky Late Neuroblast signature is the same as the earlier Neuroblast signature, but NEFM and ALK are now absent (meaning lower expressed at later stages of differentiation):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.82e-01
Mean rank of genes in gene set: 9679.8
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71
SYN3	-0.0002289	10141	GTEx	DepMap	Descartes	0.02	0.65
IL7	-0.0006888	12356	GTEx	DepMap	Descartes	0.07	5.44
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

E Chromaffin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Epinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.83e-01
Mean rank of genes in gene set: 9418.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANK3	0.0007003	1301	GTEx	DepMap	Descartes	0.34	7.42
DLK1	-0.0000505	6392	GTEx	DepMap	Descartes	0.62	32.03
RAB3B	-0.0003984	11670	GTEx	DepMap	Descartes	0.04	0.51
RAB3C	-0.0006250	12295	GTEx	DepMap	Descartes	0.07	0.88
NPY	-0.0007484	12403	GTEx	DepMap	Descartes	5.01	1135.62
GATA2	-0.0008528	12451	GTEx	DepMap	Descartes	0.14	5.98

M-MDSC
These marker genes were curated for MDSC subtypes as reviewed in Veglia et. al. (PMID 33526920):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 8280.4
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL10	0.0001369	3631	GTEx	DepMap	Descartes	0.23	20.97
CD14	-0.0000282	5813	GTEx	DepMap	Descartes	1.83	197.54
NOS2	-0.0000451	6252	GTEx	DepMap	Descartes	0.00	0.00
CD84	-0.0000702	6864	GTEx	DepMap	Descartes	0.09	2.60
ARG1	-0.0001042	7695	GTEx	DepMap	Descartes	0.00	0.00
CD274	-0.0001061	7736	GTEx	DepMap	Descartes	0.02	0.42
TNFRSF10B	-0.0001137	7917	GTEx	DepMap	Descartes	0.08	3.87
HIF1A	-0.0001204	8065	GTEx	DepMap	Descartes	0.42	25.89
TGFB1	-0.0001278	8240	GTEx	DepMap	Descartes	0.33	32.42
STAT3	-0.0001387	8477	GTEx	DepMap	Descartes	0.90	45.59
CD36	-0.0001968	9629	GTEx	DepMap	Descartes	0.10	2.15
TNF	-0.0002141	9927	GTEx	DepMap	Descartes	0.30	39.96
VEGFA	-0.0003216	11161	GTEx	DepMap	Descartes	0.13	2.14
IL1B	-0.0003248	11182	GTEx	DepMap	Descartes	1.07	136.55
ARG2	-0.0003879	11617	GTEx	DepMap	Descartes	0.09	4.17

SCPs mouse unique (Olsen)
Selected list of SCP marker genes shown in Fig. 2B of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these genes were unique to mouse SCPs as determined by the linearge tracing study Furlan et al. (Science 2017, PMID 28684471).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.85e-01
Mean rank of genes in gene set: 10192.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCRG1	-0.0001360	8424	GTEx	DepMap	Descartes	0.17	10.64
CRABP1	-0.0001731	9166	GTEx	DepMap	Descartes	0.12	8.08
POSTN	-0.0002750	10733	GTEx	DepMap	Descartes	0.14	7.49
H1FX	-0.0008438	12447	GTEx	DepMap	Descartes	1.25	NA

Immune cells (Yuan)
Obtained from Fig. 1 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 12003
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PTPRC	-0.0004392	11864	GTEx	DepMap	Descartes	0.30	9.61
CXCR4	-0.0005309	12142	GTEx	DepMap	Descartes	0.84	94.47

Meta_9 ATRX (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.88e-01
Mean rank of genes in gene set: 12052
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ATRX	-0.0003872	11613	GTEx	DepMap	Descartes	0.59	16.67
ZFHX3	-0.0009886	12491	GTEx	DepMap	Descartes	0.75	7.77

Neuroblastoma (Kildisiute)
Neuroblastoma markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.90e-01
Mean rank of genes in gene set: 12228.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYCN	-0.0004602	11944	GTEx	DepMap	Descartes	0.56	11.58
PHOX2A	-0.0011098	12513	GTEx	DepMap	Descartes	1.09	63.01

Chromaffin cell-like (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.91e-01
Mean rank of genes in gene set: 12383.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0007003	12364	GTEx	DepMap	Descartes	0.09	2.94
NPY	-0.0007484	12403	GTEx	DepMap	Descartes	5.01	1135.62

Adrenergic (Olsen)
Markers listed in on page 3 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these markers are for adrenergic genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12451.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77

Chromaffin (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. These markers are expressed at a lower level in symphathoblasts.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12466
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33

Meta5 unclear (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.92e-01
Mean rank of genes in gene set: 12500
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
STMN1	-0.0008731	12458	GTEx	DepMap	Descartes	5.00	397.88
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Chromaffin cell development (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 12511.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HAND2	-0.0010099	12494	GTEx	DepMap	Descartes	0.74	31.47
GATA3	-0.0012414	12529	GTEx	DepMap	Descartes	0.60	32.19

Neuroblasts (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-01
Mean rank of genes in gene set: 9843.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71
ALK	-0.0001348	8392	GTEx	DepMap	Descartes	0.04	1.76
SYN3	-0.0002289	10141	GTEx	DepMap	Descartes	0.02	0.65
NEFM	-0.0005177	12114	GTEx	DepMap	Descartes	0.15	5.15
IL7	-0.0006888	12356	GTEx	DepMap	Descartes	0.07	5.44
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 11486.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CDK1	-0.0003599	11438	GTEx	DepMap	Descartes	0.22	8.72
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
UBE2C	-0.0003697	11510	GTEx	DepMap	Descartes	0.22	15.24
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

Sympathobasts or chromaffin (Kildisiute)
Sympathoblast and chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12393
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGB	-0.0006090	12276	GTEx	DepMap	Descartes	0.77	44.60
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77

Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12397.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EIF3F	-0.0006047	12272	GTEx	DepMap	Descartes	1.49	53.24
EIF3E	-0.0007293	12389	GTEx	DepMap	Descartes	1.86	253.09
EIF3L	-0.0012828	12532	GTEx	DepMap	Descartes	1.36	92.62

Meta_7 undefined sympathetic (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12402.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TUBB2A	-0.0006175	12286	GTEx	DepMap	Descartes	1.09	145.28
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33

Chromaffin Cells (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: the neuronal markers NPY, PRPH, NTRK1 and ISL1 are used to annotate chromaffin cells; these were clearly expressed in neuroblasts in our analyses.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 12450.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK1	-0.0007003	12364	GTEx	DepMap	Descartes	0.09	2.94
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
PHOX2A	-0.0011098	12513	GTEx	DepMap	Descartes	1.09	63.01

Bridge region adrenergic transition (Olsen)
As above but for cells in the mesenchymal transitioning to adrenergic region:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12508.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS5	-0.0008439	12449	GTEx	DepMap	Descartes	1.73	59.20
MLLT11	-0.0013018	12535	GTEx	DepMap	Descartes	1.77	118.30
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Chromaffin and connecting progenitor cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12438.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DDC	-0.0007169	12375	GTEx	DepMap	Descartes	0.12	8.91
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33

Late chromaffin cells (Jansky Fig1E)
Heatmap in Fig. 1E, marker genes derived from Jansks scRNA-seq data for adrenal medulla cell types. Note: this late chromaffin cell signature also includes PNMT, which is an enzyme catalyzing methylation of norepinephrine to form epinephrine; this marker is absent from the ealier less differentiated chromaffin cells (which may have been referred to as sympathoblasts in other datasets, I think):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12438.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DDC	-0.0007169	12375	GTEx	DepMap	Descartes	0.12	8.91
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33

Symphathoblasts (Kameneva)
Marker gene were obtained from Fig. 1D of Kameneva et al (PMID 33833454). These genes were used by the authors to annotate each cell type in their human fetal adrenal scRNA-seq data obtained 6, 8, 9, 11, 12 and 14 weeks post conception. Several of these markers are also (more weakly) expressed in chromaffin cells. The authors data suggest Symphthoblasts give rise to chromaffin cells.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12508.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
ELAVL3	-0.0009723	12487	GTEx	DepMap	Descartes	0.33	11.38
ELAVL4	-0.0012736	12531	GTEx	DepMap	Descartes	0.92	27.63
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Committed Progenitor (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Committed Progenitor subcluster (seems to mean progenitor of chromaffin cells), which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9752.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NTRK3	0.0003126	2386	GTEx	DepMap	Descartes	0.44	4.99
NRK	0.0002786	2561	GTEx	DepMap	Descartes	0.01	0.37
PARM1	0.0000822	4177	GTEx	DepMap	Descartes	0.07	2.77
DGKK	-0.0001134	7911	GTEx	DepMap	Descartes	0.03	0.81
ZDBF2	-0.0002814	10799	GTEx	DepMap	Descartes	0.03	0.48
ATP6V1B2	-0.0003074	11047	GTEx	DepMap	Descartes	0.43	13.69
UNC5C	-0.0003309	11239	GTEx	DepMap	Descartes	0.02	0.21
FAM155A	-0.0003534	11390	GTEx	DepMap	Descartes	0.06	1.12
SYTL4	-0.0003658	11472	GTEx	DepMap	Descartes	0.06	2.01
NDUFA4L2	-0.0004009	11683	GTEx	DepMap	Descartes	1.00	161.32
SLC18A2	-0.0004526	11919	GTEx	DepMap	Descartes	0.04	1.63
RGS4	-0.0006146	12282	GTEx	DepMap	Descartes	0.22	9.97
RGS5	-0.0008439	12449	GTEx	DepMap	Descartes	1.73	59.20
MEG3	-0.0009271	12477	GTEx	DepMap	Descartes	2.41	55.19
SYT1	-0.0010000	12493	GTEx	DepMap	Descartes	0.46	13.02

Symphathoblasts Fig2 (Kamenva)
Marker genes were obtained from Fig. 2H of Kameneva et al (PMID 33833454) for symphathoblasts (differentiating from SCPs):
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12485
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ELAVL2	-0.0007268	12384	GTEx	DepMap	Descartes	0.18	6.10
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
HAND2	-0.0010099	12494	GTEx	DepMap	Descartes	0.74	31.47
ELAVL4	-0.0012736	12531	GTEx	DepMap	Descartes	0.92	27.63
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Broad sympathetic marker (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12442.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CHGB	-0.0006090	12276	GTEx	DepMap	Descartes	0.77	44.60
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
GATA2	-0.0008528	12451	GTEx	DepMap	Descartes	0.14	5.98
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77
HAND2	-0.0010099	12494	GTEx	DepMap	Descartes	0.74	31.47
GATA3	-0.0012414	12529	GTEx	DepMap	Descartes	0.60	32.19

Bridge (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Bridge subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11077.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TBX20	-0.0001131	7905	GTEx	DepMap	Descartes	0.00	0.00
WDR6	-0.0001573	8867	GTEx	DepMap	Descartes	0.20	15.29
RCC2	-0.0001843	9382	GTEx	DepMap	Descartes	0.28	15.11
NFASC	-0.0001912	9521	GTEx	DepMap	Descartes	0.12	2.92
GSE1	-0.0003833	11591	GTEx	DepMap	Descartes	0.12	NA
DLL3	-0.0004047	11703	GTEx	DepMap	Descartes	0.10	5.12
CDKN1C	-0.0004068	11720	GTEx	DepMap	Descartes	0.42	55.07
MIAT	-0.0006988	12363	GTEx	DepMap	Descartes	0.12	1.52
SOX11	-0.0007878	12423	GTEx	DepMap	Descartes	0.34	6.54
DPYSL3	-0.0008357	12442	GTEx	DepMap	Descartes	0.26	9.32
LDHB	-0.0010368	12499	GTEx	DepMap	Descartes	2.20	327.08
CKB	-0.0010971	12511	GTEx	DepMap	Descartes	0.80	91.50

N Chromafin (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Norepinepherine Chromaffin subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10583.62
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCL14	0.0031243	247	GTEx	DepMap	Descartes	0.32	42.57
LGR5	-0.0001148	7934	GTEx	DepMap	Descartes	0.01	0.04
SYN2	-0.0001788	9280	GTEx	DepMap	Descartes	0.02	0.30
ADCYAP1R1	-0.0002276	10131	GTEx	DepMap	Descartes	0.01	0.23
CACNA2D1	-0.0002594	10547	GTEx	DepMap	Descartes	0.10	2.27
SCG5	-0.0002718	10690	GTEx	DepMap	Descartes	0.80	170.58
PPFIA2	-0.0002814	10800	GTEx	DepMap	Descartes	0.02	0.39
NAP1L5	-0.0003814	11574	GTEx	DepMap	Descartes	0.12	14.83
SLCO3A1	-0.0004460	11894	GTEx	DepMap	Descartes	0.21	9.45
PTPRN	-0.0004533	11923	GTEx	DepMap	Descartes	0.31	9.63
PCLO	-0.0005338	12151	GTEx	DepMap	Descartes	0.09	0.56
C1QL1	-0.0006420	12312	GTEx	DepMap	Descartes	0.30	41.33
SNAP25	-0.0008418	12445	GTEx	DepMap	Descartes	0.17	11.43
SCG3	-0.0008594	12453	GTEx	DepMap	Descartes	0.38	18.84
CELF4	-0.0008820	12461	GTEx	DepMap	Descartes	0.34	9.02
GNAS	-0.0010217	12496	GTEx	DepMap	Descartes	4.67	225.54

Adrenergic Fig 1D (Olsen)
Similar to above, but for selected adrenergic marker genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 11774.45
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NRG1	0.0000534	4510	GTEx	DepMap	Descartes	0.08	2.12
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
RGS5	-0.0008439	12449	GTEx	DepMap	Descartes	1.73	59.20
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
MAP1B	-0.0010392	12500	GTEx	DepMap	Descartes	2.47	42.26
ELAVL4	-0.0012736	12531	GTEx	DepMap	Descartes	0.92	27.63
UCHL1	-0.0012895	12534	GTEx	DepMap	Descartes	1.47	144.67
MLLT11	-0.0013018	12535	GTEx	DepMap	Descartes	1.77	118.30
RTN1	-0.0014883	12541	GTEx	DepMap	Descartes	1.25	48.34
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12427.09
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEFL	-0.0004997	12073	GTEx	DepMap	Descartes	0.20	7.50
NEFM	-0.0005177	12114	GTEx	DepMap	Descartes	0.15	5.15
STMN1	-0.0008731	12458	GTEx	DepMap	Descartes	5.00	397.88
INA	-0.0008903	12465	GTEx	DepMap	Descartes	0.14	5.28
ISL1	-0.0009170	12474	GTEx	DepMap	Descartes	0.37	23.23
CCND1	-0.0009234	12476	GTEx	DepMap	Descartes	1.99	100.26
ELAVL3	-0.0009723	12487	GTEx	DepMap	Descartes	0.33	11.38
ELAVL4	-0.0012736	12531	GTEx	DepMap	Descartes	0.92	27.63
BASP1	-0.0014203	12537	GTEx	DepMap	Descartes	1.50	107.90
RTN1	-0.0014883	12541	GTEx	DepMap	Descartes	1.25	48.34
STMN2	-0.0015476	12542	GTEx	DepMap	Descartes	3.77	308.06

Medulla (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for genes defining the broad group labelled adrenal medulla, which included 7 subclusters (SCP, Bridge, Committed Progenitor, N Chromaffin, E Chromaffin, Neuroblast) - see UMAP on their Fig1B for cluster assignments.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 12265.94
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
DISP2	-0.0002956	10952	GTEx	DepMap	Descartes	0.03	0.73
SLC18A1	-0.0004055	11713	GTEx	DepMap	Descartes	0.01	0.26
EML5	-0.0004426	11879	GTEx	DepMap	Descartes	0.06	1.04
CYB561	-0.0005468	12182	GTEx	DepMap	Descartes	0.34	18.48
CHGB	-0.0006090	12276	GTEx	DepMap	Descartes	0.77	44.60
DDC	-0.0007169	12375	GTEx	DepMap	Descartes	0.12	8.91
NNAT	-0.0007435	12400	GTEx	DepMap	Descartes	1.17	146.61
DBH	-0.0008426	12446	GTEx	DepMap	Descartes	0.51	28.67
TH	-0.0008702	12457	GTEx	DepMap	Descartes	0.27	25.77
CHGA	-0.0009234	12475	GTEx	DepMap	Descartes	0.19	12.33
HAND2	-0.0010099	12494	GTEx	DepMap	Descartes	0.74	31.47
MAP1B	-0.0010392	12500	GTEx	DepMap	Descartes	2.47	42.26
PHOX2A	-0.0011098	12513	GTEx	DepMap	Descartes	1.09	63.01
GATA3	-0.0012414	12529	GTEx	DepMap	Descartes	0.60	32.19
PCSK1N	-0.0012533	12530	GTEx	DepMap	Descartes	1.60	217.43
UCHL1	-0.0012895	12534	GTEx	DepMap	Descartes	1.47	144.67

Plasmacytoid dendritic cells (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Adrenal Cortex (Yuan)
Obtained from Fig. 6 of Yuan et al. https://www.biorxiv.org/content/10.1101/2020.05.15.097469v1:
Symphatoblasts (Dong)
Obtained from Fig. 3c of Dong et al. (PMID 32946775). Jansky et al (PMID) criticize this choice of markers, stating: Sympathoblasts were identified by Dong et al.28 based on the expression of CARTPT and INSM1, which we found expressed in chromaffin cells:
Autonomic neurons mouse (olsen)
Stated on page 6 of the main text of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - seems to be referencing previous mouse lineage tracing studies in mouse which sucggested SCPs give rise to autonomic neurons and mesenchymal cells:
Erythroblast (Kildisiute)
Erythroblast markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Chromaffin (Kildisiute)
Chromaffin markers obtained from Kildisiute et al, Supplmenentary Table 2, references supporting these genes are provided in Supp Table S2 of Kildisiute et al (PMID 33547074) https://www.science.org/doi/suppl/10.1126/sciadv.abd3311/suppl_file/abd3311_tables_s1_to_s12.xlsx:
Cortex (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for their broad Cortex group, which is composed of Fetal Zone, Definitive Zone and Adr Primordium subclusters:
Adrenal cortical (Jansky)
Mentioned in the main text (Jansky et al, Nature Genetics (2021)), page 1, that CYP11A1+ Adrenal cortical cells were identified in their fetal adrenal glands, this is also highlighted in the UMAP plot on their Fig 1B. Additional genes also shown in their Extended data Figure 2D.:

Below shows ranks on this GEP for literature curated gene lists for large gene sets
These include those reported as mesenchymal/adrenergic by Van Groningen et al.
High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10375.28
Median rank of genes in gene set: 11536
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
AP1S2	0.0061818	92	GTEx	DepMap	Descartes	2.33	254.22
L1CAM	0.0024755	330	GTEx	DepMap	Descartes	0.80	69.47
CELF2	0.0018775	456	GTEx	DepMap	Descartes	0.94	42.75
HEY1	0.0014305	602	GTEx	DepMap	Descartes	0.18	18.62
TMOD2	0.0012929	672	GTEx	DepMap	Descartes	0.43	19.28
CDKN2C	0.0010719	827	GTEx	DepMap	Descartes	0.38	47.08
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71
GLDC	0.0004997	1725	GTEx	DepMap	Descartes	0.03	2.99
POPDC3	0.0004153	1971	GTEx	DepMap	Descartes	0.09	16.02
PPP1R9A	0.0003988	2036	GTEx	DepMap	Descartes	0.16	5.22
PHPT1	0.0003803	2103	GTEx	DepMap	Descartes	2.24	521.13
CETN3	0.0003545	2214	GTEx	DepMap	Descartes	0.22	26.68
SETD7	0.0003529	2225	GTEx	DepMap	Descartes	0.14	5.14
ST3GAL6	0.0003283	2323	GTEx	DepMap	Descartes	0.15	15.68
FBXO8	0.0003230	2353	GTEx	DepMap	Descartes	0.15	24.58
PPP2R3C	0.0003023	2428	GTEx	DepMap	Descartes	0.36	53.56
REC8	0.0002875	2505	GTEx	DepMap	Descartes	0.25	30.16
MYO5A	0.0002567	2692	GTEx	DepMap	Descartes	0.19	5.17
GGCT	0.0002216	2892	GTEx	DepMap	Descartes	0.58	124.48
GRB10	0.0002196	2907	GTEx	DepMap	Descartes	0.07	3.54
EXOC5	0.0001878	3150	GTEx	DepMap	Descartes	0.20	6.85
FHOD3	0.0001749	3254	GTEx	DepMap	Descartes	0.12	6.80
LSM3	0.0001419	3563	GTEx	DepMap	Descartes	1.38	115.76
THSD7A	0.0001197	3801	GTEx	DepMap	Descartes	0.20	6.20
SYNPO2	0.0001031	3969	GTEx	DepMap	Descartes	0.47	7.88
CADM1	0.0000924	4076	GTEx	DepMap	Descartes	0.81	27.84
NPTX2	0.0000761	4236	GTEx	DepMap	Descartes	0.04	2.58
ABCA3	0.0000574	4464	GTEx	DepMap	Descartes	0.15	6.63
DUSP4	0.0000466	4588	GTEx	DepMap	Descartes	0.17	8.94
BMP7	-0.0000098	5366	GTEx	DepMap	Descartes	0.10	7.26

VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.68e-49
Mean rank of genes in gene set: 3758.78
Median rank of genes in gene set: 1921
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
PON2	0.0132064	20	GTEx	DepMap	Descartes	0.95	221.05
IFITM3	0.0126861	24	GTEx	DepMap	Descartes	20.43	11724.91
LGALS1	0.0099273	42	GTEx	DepMap	Descartes	22.85	13754.31
CNN3	0.0084416	54	GTEx	DepMap	Descartes	3.31	663.27
CSRP1	0.0078957	60	GTEx	DepMap	Descartes	1.72	79.21
SPARC	0.0077700	63	GTEx	DepMap	Descartes	9.14	958.42
VIM	0.0075168	67	GTEx	DepMap	Descartes	26.71	3434.20
RHOC	0.0071720	71	GTEx	DepMap	Descartes	2.66	451.65
CLIC4	0.0069724	73	GTEx	DepMap	Descartes	1.17	112.75
ZCCHC24	0.0065856	84	GTEx	DepMap	Descartes	0.43	32.65
PLSCR4	0.0061123	93	GTEx	DepMap	Descartes	0.33	42.69
LAMC1	0.0058604	101	GTEx	DepMap	Descartes	0.85	40.20
S1PR3	0.0056350	110	GTEx	DepMap	Descartes	0.31	13.03
B2M	0.0056256	112	GTEx	DepMap	Descartes	98.10	14686.51
ANXA1	0.0047934	139	GTEx	DepMap	Descartes	5.58	1043.81
PTN	0.0047874	141	GTEx	DepMap	Descartes	1.94	489.15
SDC4	0.0047743	142	GTEx	DepMap	Descartes	0.27	38.32
TNFRSF12A	0.0044315	157	GTEx	DepMap	Descartes	1.03	210.12
ANXA2	0.0044016	159	GTEx	DepMap	Descartes	6.56	690.99
WLS	0.0040976	174	GTEx	DepMap	Descartes	0.22	34.70
ARPC1B	0.0040264	178	GTEx	DepMap	Descartes	3.03	600.02
CYBRD1	0.0039389	184	GTEx	DepMap	Descartes	0.35	30.34
GPR137B	0.0038017	193	GTEx	DepMap	Descartes	0.35	69.94
DKK3	0.0037807	197	GTEx	DepMap	Descartes	0.91	37.36
IFITM2	0.0037679	198	GTEx	DepMap	Descartes	3.44	1424.48
NID2	0.0037550	200	GTEx	DepMap	Descartes	0.17	13.66
ID3	0.0035940	206	GTEx	DepMap	Descartes	3.06	1260.03
PHLDA3	0.0035858	207	GTEx	DepMap	Descartes	0.64	88.97
LAMP1	0.0035472	210	GTEx	DepMap	Descartes	1.43	93.89
CD63	0.0035432	212	GTEx	DepMap	Descartes	11.40	2919.01

Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.02e-01
Mean rank of genes in gene set: 6594.5
Median rank of genes in gene set: 7509.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CLU	0.0059024	99	GTEx	DepMap	Descartes	3.59	586.79
FREM2	0.0048730	136	GTEx	DepMap	Descartes	0.09	2.31
SH3PXD2B	0.0007633	1193	GTEx	DepMap	Descartes	0.12	4.04
FRMD5	0.0006849	1327	GTEx	DepMap	Descartes	0.10	5.47
SH3BP5	0.0005880	1494	GTEx	DepMap	Descartes	0.46	41.90
CYB5B	0.0004867	1761	GTEx	DepMap	Descartes	0.36	25.12
FDXR	0.0004097	1987	GTEx	DepMap	Descartes	0.11	16.30
LDLR	0.0002596	2674	GTEx	DepMap	Descartes	0.09	4.49
GRAMD1B	0.0002245	2875	GTEx	DepMap	Descartes	0.07	2.26
NPC1	0.0001901	3127	GTEx	DepMap	Descartes	0.06	2.84
POR	0.0001471	3505	GTEx	DepMap	Descartes	0.28	33.76
SCAP	0.0001388	3605	GTEx	DepMap	Descartes	0.20	15.60
PAPSS2	0.0001198	3798	GTEx	DepMap	Descartes	0.03	2.47
HMGCS1	0.0000942	4053	GTEx	DepMap	Descartes	0.14	7.64
FDX1	-0.0000405	6130	GTEx	DepMap	Descartes	0.41	34.41
BAIAP2L1	-0.0000488	6358	GTEx	DepMap	Descartes	0.00	0.00
FDPS	-0.0000687	6830	GTEx	DepMap	Descartes	0.57	74.23
MSMO1	-0.0000831	7201	GTEx	DepMap	Descartes	0.17	19.47
ERN1	-0.0001093	7818	GTEx	DepMap	Descartes	0.13	3.01
SGCZ	-0.0001151	7941	GTEx	DepMap	Descartes	0.00	0.00
STAR	-0.0001160	7962	GTEx	DepMap	Descartes	0.01	0.41
INHA	-0.0001388	8478	GTEx	DepMap	Descartes	0.00	0.00
SCARB1	-0.0001819	9334	GTEx	DepMap	Descartes	0.09	2.96
PDE10A	-0.0001820	9336	GTEx	DepMap	Descartes	0.05	1.28
DHCR7	-0.0001933	9558	GTEx	DepMap	Descartes	0.02	2.89
GSTA4	-0.0002045	9746	GTEx	DepMap	Descartes	0.38	72.25
APOC1	-0.0002308	10166	GTEx	DepMap	Descartes	6.17	1722.55
IGF1R	-0.0002373	10288	GTEx	DepMap	Descartes	0.10	1.99
JAKMIP2	-0.0002383	10299	GTEx	DepMap	Descartes	0.11	3.59
DHCR24	-0.0002527	10470	GTEx	DepMap	Descartes	0.03	1.40

Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 10921.46
Median rank of genes in gene set: 12031
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
GAP43	0.0010126	886	GTEx	DepMap	Descartes	2.72	420.71
SYNPO2	0.0001031	3969	GTEx	DepMap	Descartes	0.47	7.88
ALK	-0.0001348	8392	GTEx	DepMap	Descartes	0.04	1.76
EPHA6	-0.0001460	8625	GTEx	DepMap	Descartes	0.00	0.00
SLC44A5	-0.0001494	8708	GTEx	DepMap	Descartes	0.01	0.39
RPH3A	-0.0001716	9137	GTEx	DepMap	Descartes	0.00	0.00
ANKFN1	-0.0001756	9209	GTEx	DepMap	Descartes	0.01	0.44
RGMB	-0.0001878	9458	GTEx	DepMap	Descartes	0.19	8.12
CNKSR2	-0.0002052	9767	GTEx	DepMap	Descartes	0.02	0.92
PLXNA4	-0.0002202	10008	GTEx	DepMap	Descartes	0.03	0.54
HS3ST5	-0.0002462	10398	GTEx	DepMap	Descartes	0.02	1.76
RYR2	-0.0002556	10495	GTEx	DepMap	Descartes	0.02	0.05
GREM1	-0.0002655	10612	GTEx	DepMap	Descartes	0.00	0.00
FAT3	-0.0002708	10676	GTEx	DepMap	Descartes	0.01	0.05
EYA4	-0.0002717	10689	GTEx	DepMap	Descartes	0.01	0.25
EYA1	-0.0002979	10969	GTEx	DepMap	Descartes	0.04	1.20
KCNB2	-0.0003154	11115	GTEx	DepMap	Descartes	0.01	0.21
PTCHD1	-0.0003361	11267	GTEx	DepMap	Descartes	0.01	0.05
TMEM132C	-0.0003939	11646	GTEx	DepMap	Descartes	0.02	0.39
SLC6A2	-0.0004385	11860	GTEx	DepMap	Descartes	0.01	0.37
RBFOX1	-0.0004866	12031	GTEx	DepMap	Descartes	0.04	1.30
TMEFF2	-0.0005213	12123	GTEx	DepMap	Descartes	0.05	1.67
GAL	-0.0005482	12185	GTEx	DepMap	Descartes	0.23	49.31
REEP1	-0.0005672	12212	GTEx	DepMap	Descartes	0.07	1.81
TUBB2A	-0.0006175	12286	GTEx	DepMap	Descartes	1.09	145.28
MAB21L2	-0.0006399	12310	GTEx	DepMap	Descartes	0.18	5.47
MAB21L1	-0.0006636	12335	GTEx	DepMap	Descartes	0.28	14.83
IL7	-0.0006888	12356	GTEx	DepMap	Descartes	0.07	5.44
NTRK1	-0.0007003	12364	GTEx	DepMap	Descartes	0.09	2.94
ELAVL2	-0.0007268	12384	GTEx	DepMap	Descartes	0.18	6.10

Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.63e-01
Mean rank of genes in gene set: 7322.66
Median rank of genes in gene set: 7560.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
GALNT15	0.0003838	2093	GTEx	DepMap	Descartes	0.01	NA
ID1	0.0003082	2405	GTEx	DepMap	Descartes	0.38	102.73
CDH13	0.0002537	2715	GTEx	DepMap	Descartes	0.07	1.44
F8	0.0001916	3109	GTEx	DepMap	Descartes	0.02	0.86
SHE	0.0000742	4261	GTEx	DepMap	Descartes	0.02	0.90
CEACAM1	0.0000735	4272	GTEx	DepMap	Descartes	0.01	0.60
BTNL9	0.0000566	4474	GTEx	DepMap	Descartes	0.01	0.20
KANK3	0.0000561	4483	GTEx	DepMap	Descartes	0.04	4.45
CRHBP	0.0000126	5006	GTEx	DepMap	Descartes	0.04	3.60
TIE1	0.0000094	5050	GTEx	DepMap	Descartes	0.02	0.83
NOTCH4	0.0000017	5159	GTEx	DepMap	Descartes	0.09	4.28
RASIP1	-0.0000016	5217	GTEx	DepMap	Descartes	0.02	0.71
SLCO2A1	-0.0000041	5258	GTEx	DepMap	Descartes	0.02	1.43
NR5A2	-0.0000072	5321	GTEx	DepMap	Descartes	0.01	0.22
ESM1	-0.0000357	6012	GTEx	DepMap	Descartes	0.00	0.00
PTPRB	-0.0000505	6390	GTEx	DepMap	Descartes	0.08	0.90
NPR1	-0.0000703	6865	GTEx	DepMap	Descartes	0.01	1.10
HYAL2	-0.0000817	7174	GTEx	DepMap	Descartes	0.31	18.70
KDR	-0.0000857	7260	GTEx	DepMap	Descartes	0.02	0.40
FLT4	-0.0001114	7861	GTEx	DepMap	Descartes	0.01	0.19
TMEM88	-0.0001316	8328	GTEx	DepMap	Descartes	0.10	20.61
IRX3	-0.0001390	8483	GTEx	DepMap	Descartes	0.02	1.95
MYRIP	-0.0001408	8527	GTEx	DepMap	Descartes	0.02	0.48
PLVAP	-0.0001512	8756	GTEx	DepMap	Descartes	0.07	4.47
CYP26B1	-0.0001713	9132	GTEx	DepMap	Descartes	0.09	2.13
EHD3	-0.0001883	9469	GTEx	DepMap	Descartes	0.03	0.97
SHANK3	-0.0001939	9572	GTEx	DepMap	Descartes	0.02	0.27
CDH5	-0.0002083	9823	GTEx	DepMap	Descartes	0.02	0.93
PODXL	-0.0002087	9827	GTEx	DepMap	Descartes	0.05	1.11
EFNB2	-0.0002134	9915	GTEx	DepMap	Descartes	0.14	5.68

Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.06e-01
Mean rank of genes in gene set: 6745.18
Median rank of genes in gene set: 7432
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CLDN11	0.0021695	378	GTEx	DepMap	Descartes	0.06	5.86
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
COL27A1	0.0016951	503	GTEx	DepMap	Descartes	0.09	3.11
COL12A1	0.0016814	508	GTEx	DepMap	Descartes	0.37	10.77
RSPO3	0.0015454	553	GTEx	DepMap	Descartes	0.05	NA
COL3A1	0.0013487	647	GTEx	DepMap	Descartes	2.98	184.36
ABCA6	0.0011679	750	GTEx	DepMap	Descartes	0.30	14.11
ISLR	0.0009140	980	GTEx	DepMap	Descartes	0.45	64.41
FREM1	0.0003766	2123	GTEx	DepMap	Descartes	0.05	1.40
ADAMTS2	0.0002318	2836	GTEx	DepMap	Descartes	0.09	3.29
GLI2	0.0002289	2851	GTEx	DepMap	Descartes	0.02	1.00
PAMR1	0.0001912	3113	GTEx	DepMap	Descartes	0.28	22.26
BICC1	0.0000856	4141	GTEx	DepMap	Descartes	0.25	10.32
ACTA2	0.0000570	4467	GTEx	DepMap	Descartes	1.20	207.80
PRRX1	0.0000242	4860	GTEx	DepMap	Descartes	0.23	14.32
ADAMTSL3	-0.0000586	6583	GTEx	DepMap	Descartes	0.00	0.00
LOX	-0.0000673	6797	GTEx	DepMap	Descartes	0.05	2.70
CDH11	-0.0000742	6961	GTEx	DepMap	Descartes	0.14	5.72
EDNRA	-0.0000819	7178	GTEx	DepMap	Descartes	0.05	3.53
LRRC17	-0.0000870	7293	GTEx	DepMap	Descartes	0.06	6.18
ABCC9	-0.0000872	7300	GTEx	DepMap	Descartes	0.04	0.93
GAS2	-0.0000910	7393	GTEx	DepMap	Descartes	0.00	0.00
ITGA11	-0.0000942	7471	GTEx	DepMap	Descartes	0.01	0.38
COL6A3	-0.0001057	7728	GTEx	DepMap	Descartes	0.48	12.84
LAMC3	-0.0001183	8019	GTEx	DepMap	Descartes	0.00	0.00
DKK2	-0.0001293	8269	GTEx	DepMap	Descartes	0.00	0.00
IGFBP3	-0.0001456	8619	GTEx	DepMap	Descartes	0.12	9.27
C7	-0.0001482	8676	GTEx	DepMap	Descartes	0.22	11.50
CD248	-0.0001531	8787	GTEx	DepMap	Descartes	0.07	6.88
SCARA5	-0.0001538	8807	GTEx	DepMap	Descartes	0.07	4.35

Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 9092.92
Median rank of genes in gene set: 9678.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
PENK	0.0042416	167	GTEx	DepMap	Descartes	0.37	83.03
SLC35F3	0.0001735	3265	GTEx	DepMap	Descartes	0.01	1.47
GRM7	0.0001113	3878	GTEx	DepMap	Descartes	0.01	0.70
PCSK2	0.0000374	4693	GTEx	DepMap	Descartes	0.04	2.65
NTNG1	-0.0000246	5726	GTEx	DepMap	Descartes	0.05	2.85
PACRG	-0.0000422	6176	GTEx	DepMap	Descartes	0.02	6.93
LAMA3	-0.0000505	6391	GTEx	DepMap	Descartes	0.00	0.00
ST18	-0.0000987	7578	GTEx	DepMap	Descartes	0.00	0.00
SORCS3	-0.0001005	7609	GTEx	DepMap	Descartes	0.00	0.00
CDH12	-0.0001025	7656	GTEx	DepMap	Descartes	0.01	0.53
TENM1	-0.0001108	7848	GTEx	DepMap	Descartes	0.06	NA
TBX20	-0.0001131	7905	GTEx	DepMap	Descartes	0.00	0.00
DGKK	-0.0001134	7911	GTEx	DepMap	Descartes	0.03	0.81
CNTN3	-0.0001172	7990	GTEx	DepMap	Descartes	0.00	0.00
CDH18	-0.0001182	8017	GTEx	DepMap	Descartes	0.01	0.36
SLC24A2	-0.0001277	8239	GTEx	DepMap	Descartes	0.01	0.08
MGAT4C	-0.0001469	8644	GTEx	DepMap	Descartes	0.09	0.76
CCSER1	-0.0001746	9191	GTEx	DepMap	Descartes	0.01	NA
EML6	-0.0001852	9401	GTEx	DepMap	Descartes	0.00	0.00
GALNTL6	-0.0002160	9956	GTEx	DepMap	Descartes	0.01	0.21
AGBL4	-0.0002172	9969	GTEx	DepMap	Descartes	0.01	0.41
GRID2	-0.0002358	10250	GTEx	DepMap	Descartes	0.01	0.03
FGF14	-0.0002521	10464	GTEx	DepMap	Descartes	0.07	0.90
KSR2	-0.0002758	10742	GTEx	DepMap	Descartes	0.02	0.22
SPOCK3	-0.0002846	10834	GTEx	DepMap	Descartes	0.02	1.29
UNC80	-0.0003475	11357	GTEx	DepMap	Descartes	0.06	0.36
FAM155A	-0.0003534	11390	GTEx	DepMap	Descartes	0.06	1.12
ROBO1	-0.0003622	11451	GTEx	DepMap	Descartes	0.08	1.81
TIAM1	-0.0003913	11633	GTEx	DepMap	Descartes	0.10	3.60
ARC	-0.0004043	11699	GTEx	DepMap	Descartes	0.36	32.37

Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.37e-01
Mean rank of genes in gene set: 5793.55
Median rank of genes in gene set: 5745
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
SNCA	0.0057711	105	GTEx	DepMap	Descartes	1.28	186.22
CAT	0.0020490	412	GTEx	DepMap	Descartes	0.47	84.69
BLVRB	0.0007440	1223	GTEx	DepMap	Descartes	0.79	176.32
SELENBP1	0.0006087	1464	GTEx	DepMap	Descartes	0.13	8.92
TSPAN5	0.0005507	1597	GTEx	DepMap	Descartes	0.43	35.92
SLC25A21	0.0003412	2279	GTEx	DepMap	Descartes	0.00	0.00
RGS6	0.0002634	2649	GTEx	DepMap	Descartes	0.02	1.72
SPECC1	0.0002143	2953	GTEx	DepMap	Descartes	0.06	2.81
MARCH3	0.0001774	3231	GTEx	DepMap	Descartes	0.07	NA
XPO7	0.0000882	4120	GTEx	DepMap	Descartes	0.10	6.47
SOX6	0.0000610	4416	GTEx	DepMap	Descartes	0.10	3.92
SLC4A1	-0.0000002	5192	GTEx	DepMap	Descartes	0.01	0.18
RAPGEF2	-0.0000102	5373	GTEx	DepMap	Descartes	0.12	3.23
RHD	-0.0000240	5712	GTEx	DepMap	Descartes	0.00	0.00
ABCB10	-0.0000255	5745	GTEx	DepMap	Descartes	0.06	3.13
TRAK2	-0.0000290	5833	GTEx	DepMap	Descartes	0.10	4.36
SLC25A37	-0.0000373	6045	GTEx	DepMap	Descartes	0.31	14.76
ALAS2	-0.0000508	6400	GTEx	DepMap	Descartes	0.00	0.00
GYPC	-0.0000841	7227	GTEx	DepMap	Descartes	0.77	114.09
TMCC2	-0.0000920	7427	GTEx	DepMap	Descartes	0.04	0.96
FECH	-0.0001065	7748	GTEx	DepMap	Descartes	0.07	2.41
CPOX	-0.0001564	8846	GTEx	DepMap	Descartes	0.04	3.02
ANK1	-0.0001828	9353	GTEx	DepMap	Descartes	0.02	0.26
SPTB	-0.0001979	9649	GTEx	DepMap	Descartes	0.01	0.25
DENND4A	-0.0002238	10061	GTEx	DepMap	Descartes	0.07	2.60
TFR2	-0.0002252	10086	GTEx	DepMap	Descartes	0.01	0.25
MICAL2	-0.0002503	10446	GTEx	DepMap	Descartes	0.03	0.56
GCLC	-0.0002534	10480	GTEx	DepMap	Descartes	0.04	1.98
EPB41	-0.0004585	11941	GTEx	DepMap	Descartes	0.06	1.76
NA	NA	NA	NA	NA	NA	NA	NA

Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.22e-01
Mean rank of genes in gene set: 6003.42
Median rank of genes in gene set: 6136
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CST3	0.0041104	172	GTEx	DepMap	Descartes	18.54	1771.14
WWP1	0.0027183	292	GTEx	DepMap	Descartes	0.33	31.59
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74
AXL	0.0021069	397	GTEx	DepMap	Descartes	0.58	34.18
CTSC	0.0019269	443	GTEx	DepMap	Descartes	2.90	114.16
ABCA1	0.0015499	550	GTEx	DepMap	Descartes	0.37	12.55
FGL2	0.0013593	643	GTEx	DepMap	Descartes	0.73	47.94
PTPRE	0.0009522	942	GTEx	DepMap	Descartes	0.49	22.82
CTSD	0.0007587	1203	GTEx	DepMap	Descartes	5.17	637.05
RGL1	0.0006303	1422	GTEx	DepMap	Descartes	0.22	14.67
FGD2	0.0002032	3034	GTEx	DepMap	Descartes	0.03	1.60
ATP8B4	0.0001364	3637	GTEx	DepMap	Descartes	0.05	2.62
MARCH1	0.0000935	4061	GTEx	DepMap	Descartes	0.17	NA
MERTK	0.0000891	4106	GTEx	DepMap	Descartes	0.09	5.15
IFNGR1	0.0000854	4146	GTEx	DepMap	Descartes	0.49	52.04
MS4A4A	-0.0000044	5264	GTEx	DepMap	Descartes	0.76	72.78
SLC1A3	-0.0000268	5778	GTEx	DepMap	Descartes	0.11	5.32
CD14	-0.0000282	5813	GTEx	DepMap	Descartes	1.83	197.54
CSF1R	-0.0000285	5824	GTEx	DepMap	Descartes	0.32	18.80
SLC9A9	-0.0000528	6448	GTEx	DepMap	Descartes	0.09	8.98
LGMN	-0.0000944	7474	GTEx	DepMap	Descartes	0.90	80.25
HCK	-0.0001151	7940	GTEx	DepMap	Descartes	0.09	9.02
SPP1	-0.0001328	8353	GTEx	DepMap	Descartes	3.08	256.31
CD163	-0.0001437	8586	GTEx	DepMap	Descartes	0.16	8.03
CTSB	-0.0001484	8681	GTEx	DepMap	Descartes	2.82	107.34
SFMBT2	-0.0001523	8773	GTEx	DepMap	Descartes	0.06	2.51
MSR1	-0.0001585	8898	GTEx	DepMap	Descartes	0.26	15.48
HRH1	-0.0001610	8949	GTEx	DepMap	Descartes	0.02	1.55
ADAP2	-0.0001849	9393	GTEx	DepMap	Descartes	0.24	15.96
RBPJ	-0.0001950	9598	GTEx	DepMap	Descartes	0.60	23.80

Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.97e-15
Mean rank of genes in gene set: 2019.66
Median rank of genes in gene set: 387
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
PLP1	0.0233658	2	GTEx	DepMap	Descartes	4.44	653.76
MPZ	0.0130732	21	GTEx	DepMap	Descartes	2.96	710.50
ERBB3	0.0127857	23	GTEx	DepMap	Descartes	0.87	62.27
SCN7A	0.0095106	47	GTEx	DepMap	Descartes	1.28	82.15
VIM	0.0075168	67	GTEx	DepMap	Descartes	26.71	3434.20
EDNRB	0.0074048	68	GTEx	DepMap	Descartes	0.64	51.59
PMP22	0.0069335	75	GTEx	DepMap	Descartes	4.84	1243.69
GFRA3	0.0064768	86	GTEx	DepMap	Descartes	1.50	332.45
LAMC1	0.0058604	101	GTEx	DepMap	Descartes	0.85	40.20
NRXN3	0.0056148	113	GTEx	DepMap	Descartes	0.19	9.61
STARD13	0.0054622	116	GTEx	DepMap	Descartes	0.36	23.09
GAS7	0.0053815	121	GTEx	DepMap	Descartes	0.86	37.77
PTN	0.0047874	141	GTEx	DepMap	Descartes	1.94	489.15
NRXN1	0.0046309	147	GTEx	DepMap	Descartes	2.20	105.92
LAMA4	0.0042892	164	GTEx	DepMap	Descartes	0.67	41.75
SLC35F1	0.0040849	175	GTEx	DepMap	Descartes	0.37	26.35
PTPRZ1	0.0034294	224	GTEx	DepMap	Descartes	0.27	12.74
XKR4	0.0033854	228	GTEx	DepMap	Descartes	0.25	4.54
KCTD12	0.0031700	241	GTEx	DepMap	Descartes	0.89	47.25
GRIK3	0.0031232	248	GTEx	DepMap	Descartes	0.09	3.19
SORCS1	0.0025018	325	GTEx	DepMap	Descartes	0.27	15.65
HMGA2	0.0021359	386	GTEx	DepMap	Descartes	0.02	1.27
OLFML2A	0.0021324	388	GTEx	DepMap	Descartes	0.66	28.69
FIGN	0.0019398	435	GTEx	DepMap	Descartes	0.35	12.28
COL5A2	0.0019056	449	GTEx	DepMap	Descartes	0.75	34.38
LAMB1	0.0017924	476	GTEx	DepMap	Descartes	0.40	26.58
COL18A1	0.0016066	532	GTEx	DepMap	Descartes	1.90	93.60
TRPM3	0.0012542	690	GTEx	DepMap	Descartes	0.04	1.36
EGFLAM	0.0009482	948	GTEx	DepMap	Descartes	0.14	14.80
IL1RAPL1	0.0008392	1081	GTEx	DepMap	Descartes	0.04	5.42

Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.93e-01
Mean rank of genes in gene set: 6402.09
Median rank of genes in gene set: 6882
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
CD9	0.0048279	138	GTEx	DepMap	Descartes	2.60	625.42
GSN	0.0013953	622	GTEx	DepMap	Descartes	5.77	275.89
THBS1	0.0013863	628	GTEx	DepMap	Descartes	0.74	28.19
FLNA	0.0007663	1187	GTEx	DepMap	Descartes	1.10	35.24
TLN1	0.0006737	1345	GTEx	DepMap	Descartes	0.64	21.14
VCL	0.0004777	1784	GTEx	DepMap	Descartes	0.50	16.40
TMSB4X	0.0004631	1830	GTEx	DepMap	Descartes	65.56	10638.13
STOM	0.0004137	1976	GTEx	DepMap	Descartes	0.59	45.34
TPM4	0.0003486	2248	GTEx	DepMap	Descartes	1.91	101.70
UBASH3B	0.0002124	2967	GTEx	DepMap	Descartes	0.06	2.82
LTBP1	0.0002105	2977	GTEx	DepMap	Descartes	0.18	7.11
DOK6	0.0002088	2994	GTEx	DepMap	Descartes	0.09	2.65
MYH9	0.0001822	3195	GTEx	DepMap	Descartes	0.61	21.96
ANGPT1	0.0001671	3309	GTEx	DepMap	Descartes	0.02	1.62
ITGA2B	0.0000849	4154	GTEx	DepMap	Descartes	0.01	0.64
GP1BA	0.0000593	4440	GTEx	DepMap	Descartes	0.00	0.00
ITGB3	0.0000572	4465	GTEx	DepMap	Descartes	0.01	0.61
SLC2A3	0.0000424	4639	GTEx	DepMap	Descartes	0.70	37.40
PDE3A	0.0000032	5132	GTEx	DepMap	Descartes	0.06	2.10
ARHGAP6	-0.0000072	5320	GTEx	DepMap	Descartes	0.02	0.59
MED12L	-0.0000195	5607	GTEx	DepMap	Descartes	0.03	0.72
CD84	-0.0000702	6864	GTEx	DepMap	Descartes	0.09	2.60
RAP1B	-0.0000712	6882	GTEx	DepMap	Descartes	0.53	11.24
ZYX	-0.0000723	6908	GTEx	DepMap	Descartes	0.33	42.92
SLC24A3	-0.0000996	7591	GTEx	DepMap	Descartes	0.01	0.14
P2RX1	-0.0001227	8117	GTEx	DepMap	Descartes	0.01	0.71
TGFB1	-0.0001278	8240	GTEx	DepMap	Descartes	0.33	32.42
STON2	-0.0001394	8495	GTEx	DepMap	Descartes	0.04	1.65
FLI1	-0.0001560	8839	GTEx	DepMap	Descartes	0.05	3.21
TRPC6	-0.0001599	8918	GTEx	DepMap	Descartes	0.00	0.00

Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.53e-01
Mean rank of genes in gene set: 7210.14
Median rank of genes in gene set: 8589.5
Rank on gene expression program of top 30 genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Descartes	Mean.Counts	Mean.TPM
ARHGAP15	0.0133487	18	GTEx	DepMap	Descartes	1.94	309.44
B2M	0.0056256	112	GTEx	DepMap	Descartes	98.10	14686.51
GNG2	0.0023745	345	GTEx	DepMap	Descartes	0.85	86.76
CELF2	0.0018775	456	GTEx	DepMap	Descartes	0.94	42.75
CCND3	0.0015481	551	GTEx	DepMap	Descartes	0.55	83.58
SP100	0.0013372	654	GTEx	DepMap	Descartes	0.64	32.61
CD44	0.0007735	1171	GTEx	DepMap	Descartes	0.99	67.87
ARID5B	0.0005845	1505	GTEx	DepMap	Descartes	0.55	20.10
WIPF1	0.0005432	1615	GTEx	DepMap	Descartes	0.44	32.38
MSN	0.0003648	2176	GTEx	DepMap	Descartes	0.54	40.16
ITPKB	0.0003516	2229	GTEx	DepMap	Descartes	0.06	3.63
MBNL1	0.0001766	3238	GTEx	DepMap	Descartes	0.43	19.89
ANKRD44	0.0001189	3806	GTEx	DepMap	Descartes	0.15	7.61
PLEKHA2	0.0000224	4883	GTEx	DepMap	Descartes	0.13	6.92
BCL2	-0.0000095	5362	GTEx	DepMap	Descartes	0.20	10.49
LEF1	-0.0000374	6051	GTEx	DepMap	Descartes	0.19	18.40
MCTP2	-0.0000419	6168	GTEx	DepMap	Descartes	0.03	1.05
ETS1	-0.0000467	6299	GTEx	DepMap	Descartes	0.11	5.97
TOX	-0.0000744	6971	GTEx	DepMap	Descartes	0.06	3.58
BACH2	-0.0000910	7395	GTEx	DepMap	Descartes	0.07	1.80
DOCK10	-0.0001406	8520	GTEx	DepMap	Descartes	0.10	3.73
NCALD	-0.0001474	8659	GTEx	DepMap	Descartes	0.09	7.26
SAMD3	-0.0001615	8955	GTEx	DepMap	Descartes	0.01	1.57
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08
RCSD1	-0.0002434	10361	GTEx	DepMap	Descartes	0.14	5.80
SKAP1	-0.0002551	10492	GTEx	DepMap	Descartes	0.01	0.66
PRKCH	-0.0002556	10496	GTEx	DepMap	Descartes	0.01	0.18
STK39	-0.0002809	10793	GTEx	DepMap	Descartes	0.10	10.77
PITPNC1	-0.0003046	11027	GTEx	DepMap	Descartes	0.06	3.23
IKZF1	-0.0003134	11094	GTEx	DepMap	Descartes	0.06	2.18

Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
High ranks indicate this gene is a driver of this GEP.
These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

B cells: Memory B cells (model markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.18e-02
Mean rank of genes in gene set: 476.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74
HES1	0.0014551	593	GTEx	DepMap	Descartes	1.25	307.29

B cells: Naive B cells (model markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.27e-02
Mean rank of genes in gene set: 1148.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74
YBX3	0.0004251	1937	GTEx	DepMap	Descartes	0.98	NA

Macrophages: Kupffer cells (model markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.55e-02
Mean rank of genes in gene set: 2740.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0042416	167	GTEx	DepMap	Descartes	0.37	83.03
EGR2	0.0009114	987	GTEx	DepMap	Descartes	0.43	40.54
ARRDC3	0.0005042	1712	GTEx	DepMap	Descartes	0.70	47.09
CD5L	-0.0001221	8096	GTEx	DepMap	Descartes	0.04	1.23

DC: Transitional DC (curated markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.72e-02
Mean rank of genes in gene set: 1347
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AXL	0.0021069	397	GTEx	DepMap	Descartes	0.58	34.18
KLF4	0.0003355	2297	GTEx	DepMap	Descartes	0.88	69.57

Early MK: Early MK (curated markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.19e-02
Mean rank of genes in gene set: 9
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	0.0193852	9	GTEx	DepMap	Descartes	0.83	202.13

T cells: Memory CD4+ cytotoxic T cells (model markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.59e-02
Mean rank of genes in gene set: 167
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0042416	167	GTEx	DepMap	Descartes	0.37	83.03

Megakaryocytes/platelets: Megakaryocytes/platelets (curated markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.08e-02
Mean rank of genes in gene set: 2081.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CMTM5	0.0193852	9	GTEx	DepMap	Descartes	0.83	202.13
ITGA2B	0.0000849	4154	GTEx	DepMap	Descartes	0.01	0.64

Macrophages: Kidney-resident macrophages (curated markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.13e-02
Mean rank of genes in gene set: 360
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74

B cells: Transitional B cells (curated markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.68e-02
Mean rank of genes in gene set: 544
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MYO1C	0.0015664	544	GTEx	DepMap	Descartes	0.4	25.19

MNP: MNP (curated markers)
mononuclear phagocytes including dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.00e-02
Mean rank of genes in gene set: 643
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FGL2	0.0013593	643	GTEx	DepMap	Descartes	0.73	47.94

B cells: B cells (model markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.48e-02
Mean rank of genes in gene set: 3105.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74
MALAT1	0.0018697	458	GTEx	DepMap	Descartes	316.67	11636.64
CD79A	-0.0001396	8499	GTEx	DepMap	Descartes	0.00	0.00

B-cell lineage: Large pre-B cells (model markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.58e-02
Mean rank of genes in gene set: 1081
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	0.0008392	1081	GTEx	DepMap	Descartes	0.04	5.42

DC: DC1 (model markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.58e-02
Mean rank of genes in gene set: 1081
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	0.0008392	1081	GTEx	DepMap	Descartes	0.04	5.42

Erythrocytes: Erythrocytes (model markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.58e-02
Mean rank of genes in gene set: 1081
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL1RAPL1	0.0008392	1081	GTEx	DepMap	Descartes	0.04	5.42

ETP: ETP (model markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.74e-02
Mean rank of genes in gene set: 2799
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PENK	0.0042416	167	GTEx	DepMap	Descartes	0.37	83.03
WDR49	-0.0000125	5431	GTEx	DepMap	Descartes	0.01	0.40

Mono-mac: Mono-mac (model markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.61e-02
Mean rank of genes in gene set: 3913.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FTH1	0.0011618	754	GTEx	DepMap	Descartes	56.43	13052.39
S100A2	0.0004094	1988	GTEx	DepMap	Descartes	0.02	5.69
SAT1	0.0001605	3370	GTEx	DepMap	Descartes	8.31	1728.99
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91

T cells: Type 1 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.81e-02
Mean rank of genes in gene set: 4181.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	0.0050427	132	GTEx	DepMap	Descartes	0.09	5.45
ANXA1	0.0047934	139	GTEx	DepMap	Descartes	5.58	1043.81
CEBPB	0.0006606	1363	GTEx	DepMap	Descartes	1.36	198.53
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08

T cells: Follicular helper T cells (model markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.95e-02
Mean rank of genes in gene set: 3949
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SOCS3	0.0013152	664	GTEx	DepMap	Descartes	2.48	211.60
HOXB5	0.0010980	808	GTEx	DepMap	Descartes	0.00	0.00
CH25H	0.0000307	4783	GTEx	DepMap	Descartes	0.06	11.17
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91

ILC: ILC (curated markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.12e-01
Mean rank of genes in gene set: 3727.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TLE1	0.0021265	389	GTEx	DepMap	Descartes	0.43	43.73
S100A13	0.0020242	417	GTEx	DepMap	Descartes	1.01	130.94
AREG	-0.0002442	10377	GTEx	DepMap	Descartes	0.35	74.04

Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.24e-01
Mean rank of genes in gene set: 3863
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
NEAT1	0.0012445	696	GTEx	DepMap	Descartes	5.91	66.75
SAT1	0.0001605	3370	GTEx	DepMap	Descartes	8.31	1728.99
TYROBP	-0.0000966	7523	GTEx	DepMap	Descartes	4.80	1676.03

B cells: Germinal center B cells (curated markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.28e-01
Mean rank of genes in gene set: 3370
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD40	0.0003701	2153	GTEx	DepMap	Descartes	0.18	23.50
POU2AF1	0.0000466	4587	GTEx	DepMap	Descartes	0.01	1.57

Cycling cells: Cycling T cells (model markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.29e-01
Mean rank of genes in gene set: 2175
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72

ILC: ILC3 (model markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.29e-01
Mean rank of genes in gene set: 2175
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72

Promyelocytes: Promyelocytes (model markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.29e-01
Mean rank of genes in gene set: 2175
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72

T cells: T(agonist) (model markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.63e-01
Mean rank of genes in gene set: 4928.57
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
B2M	0.0056256	112	GTEx	DepMap	Descartes	98.10	14686.51
CD74	0.0022745	360	GTEx	DepMap	Descartes	24.49	2543.74
BIRC3	0.0009572	935	GTEx	DepMap	Descartes	0.43	17.08
COTL1	0.0002226	2889	GTEx	DepMap	Descartes	1.87	79.84
ITM2A	-0.0000455	6261	GTEx	DepMap	Descartes	0.20	37.32
PTPRC	-0.0004392	11864	GTEx	DepMap	Descartes	0.30	9.61
SMS	-0.0005032	12079	GTEx	DepMap	Descartes	0.88	140.33

Early MK: Early MK (model markers)
early megakaryocytes which are committed to megakaryocyte lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.92e-01
Mean rank of genes in gene set: 4041
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
CCDC175	-0.0000321	5907	GTEx	DepMap	Descartes	0.00	NA

HSC/MPP: CMP (model markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.97e-01
Mean rank of genes in gene set: 4088
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
CPA3	-0.0000350	6001	GTEx	DepMap	Descartes	0.00	0.00

DC: DC2 (model markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.09e-01
Mean rank of genes in gene set: 4581.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CST3	0.0041104	172	GTEx	DepMap	Descartes	18.54	1771.14
AGRP	0.0000423	4641	GTEx	DepMap	Descartes	0.00	0.00
MMP9	-0.0001602	8931	GTEx	DepMap	Descartes	0.50	10.52

B-cell lineage: Small pre-B cells (model markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.28e-01
Mean rank of genes in gene set: 4926.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
AICDA	-0.0000157	5508	GTEx	DepMap	Descartes	0.00	0.00
TLDC2	-0.0000180	5567	GTEx	DepMap	Descartes	0.00	NA
CD79B	-0.0000530	6455	GTEx	DepMap	Descartes	0.03	6.92

T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.37e-01
Mean rank of genes in gene set: 5116.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0018697	458	GTEx	DepMap	Descartes	316.67	11636.64
CD44	0.0007735	1171	GTEx	DepMap	Descartes	0.99	67.87
SATB1	-0.0000139	5457	GTEx	DepMap	Descartes	0.26	9.97
ITM2A	-0.0000455	6261	GTEx	DepMap	Descartes	0.20	37.32
TMSB10	-0.0005837	12236	GTEx	DepMap	Descartes	41.86	23008.43

Double-negative thymocytes: Double-negative thymocytes (curated markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.44e-01
Mean rank of genes in gene set: 4494.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HES1	0.0014551	593	GTEx	DepMap	Descartes	1.25	307.29
FXYD2	-0.0001349	8396	GTEx	DepMap	Descartes	0.01	0.39

Erythroid: Late erythroid (model markers)
late erythroid cells following early and middle erythroid cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.65e-01
Mean rank of genes in gene set: 4662.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
SLC12A3	-0.0000808	7150	GTEx	DepMap	Descartes	0.00	0.00

pDC precursor: pDC precursor (curated markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.67e-01
Mean rank of genes in gene set: 4685
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IRF7	0.0010687	831	GTEx	DepMap	Descartes	0.73	129.12
CCDC50	-0.0001415	8539	GTEx	DepMap	Descartes	0.46	12.74

Erythroid: Early erythroid (model markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.70e-01
Mean rank of genes in gene set: 5164.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FAM178B	0.0010008	895	GTEx	DepMap	Descartes	0.01	1.82
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
PRSS57	-0.0000920	7423	GTEx	DepMap	Descartes	0.01	0.70
APOC1	-0.0002308	10166	GTEx	DepMap	Descartes	6.17	1722.55

T cells: T(agonist) (curated markers)
unconventional T cell subpopulation in the thymus which expresses MIR155HG and shares some signatures with differentiating regulatory T cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.70e-01
Mean rank of genes in gene set: 4994
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BIRC3	0.0009572	935	GTEx	DepMap	Descartes	0.43	17.08
MIR155HG	0.0004164	1968	GTEx	DepMap	Descartes	0.11	13.71
SMS	-0.0005032	12079	GTEx	DepMap	Descartes	0.88	140.33

DC: DC1 (curated markers)
conventional type 1 dendritic cells which constitute a rare dendritic cell population with superior cross-presentation ability:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.96e-01
Mean rank of genes in gene set: 4903
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CADM1	9.24e-05	4076	GTEx	DepMap	Descartes	0.81	27.84
BATF3	-2.47e-05	5730	GTEx	DepMap	Descartes	0.08	6.17

Megakaryocyte precursor: Megakaryocyte precursor (model markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.02e-01
Mean rank of genes in gene set: 4946.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADRA2A	0.0001467	3510	GTEx	DepMap	Descartes	0.04	1.38
SLC10A5	-0.0000502	6383	GTEx	DepMap	Descartes	0.00	0.00

T cells: NKT cells (model markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.13e-01
Mean rank of genes in gene set: 5258
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	0.0050427	132	GTEx	DepMap	Descartes	0.09	5.45
ITM2C	0.0001188	3808	GTEx	DepMap	Descartes	1.09	144.09
CD52	-0.0004332	11834	GTEx	DepMap	Descartes	0.32	169.57

pDC precursor: pDC precursor (model markers)
precursors of plasmacytoid dendritic cells which have intermixed lymphoid and myeloid origins and give rise to plasmacytoid dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.26e-01
Mean rank of genes in gene set: 4641
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AGRP	4.23e-05	4641	GTEx	DepMap	Descartes	0	0

ILC: Transitional NK (model markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.26e-01
Mean rank of genes in gene set: 5459.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRDM16	0.0050427	132	GTEx	DepMap	Descartes	0.09	5.45
AGRP	0.0000423	4641	GTEx	DepMap	Descartes	0.00	0.00
TYROBP	-0.0000966	7523	GTEx	DepMap	Descartes	4.80	1676.03
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91

Epithelial cells: Epithelial cells (model markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.43e-01
Mean rank of genes in gene set: 5242.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WFDC2	0.0002713	2597	GTEx	DepMap	Descartes	0.09	28.46
CDH3	-0.0001125	7888	GTEx	DepMap	Descartes	0.01	0.12

T cells: Tcm/Naive cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.67e-01
Mean rank of genes in gene set: 5405
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
B2M	0.0056256	112	GTEx	DepMap	Descartes	98.10	14686.51
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

B cells: Follicular B cells (curated markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.92e-01
Mean rank of genes in gene set: 5570
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD22	-5.50e-06	5290	GTEx	DepMap	Descartes	0.01	1.44
CXCR5	-2.95e-05	5850	GTEx	DepMap	Descartes	0.00	0.00

T cells: Trm cytotoxic T cells (curated markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.04e-01
Mean rank of genes in gene set: 5654
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA1	0.0004812	1775	GTEx	DepMap	Descartes	0.38	10.54
ITGAE	-0.0001918	9533	GTEx	DepMap	Descartes	0.42	27.96

DC: Migratory DCs (model markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.08e-01
Mean rank of genes in gene set: 5431
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
WDR49	-1.25e-05	5431	GTEx	DepMap	Descartes	0.01	0.4

Macrophages: Hofbauer cells (curated markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.10e-01
Mean rank of genes in gene set: 5448
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCIN	-1.32e-05	5448	GTEx	DepMap	Descartes	0.05	1.7

ILC: CD16+ NK cells (model markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.11e-01
Mean rank of genes in gene set: 5908.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ADAMTS1	0.0004232	1944	GTEx	DepMap	Descartes	0.32	14.79
IGFBP7	0.0000682	4338	GTEx	DepMap	Descartes	21.24	4026.09
PRSS57	-0.0000920	7423	GTEx	DepMap	Descartes	0.01	0.70
TYROBP	-0.0000966	7523	GTEx	DepMap	Descartes	4.80	1676.03
FCER1G	-0.0001311	8315	GTEx	DepMap	Descartes	2.14	730.83

T cells: CD8a/b(entry) (curated markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.11e-01
Mean rank of genes in gene set: 5457
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SATB1	-1.39e-05	5457	GTEx	DepMap	Descartes	0.26	9.97

Cycling cells: Cycling DCs (model markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.13e-01
Mean rank of genes in gene set: 5478
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MMP12	-1.48e-05	5478	GTEx	DepMap	Descartes	4.36	111.86

ILC precursor: ILC precursor (curated markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.19e-01
Mean rank of genes in gene set: 5848.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SCN1B	5.69e-05	4470	GTEx	DepMap	Descartes	0.06	3.42
HPN	-3.54e-05	6008	GTEx	DepMap	Descartes	0.00	0.00
LST1	-7.82e-05	7067	GTEx	DepMap	Descartes	1.06	155.08

T cells: Tem/Effector helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.31e-01
Mean rank of genes in gene set: 5911
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGB1	0.0013102	667	GTEx	DepMap	Descartes	3.26	304.27
AQP3	-0.0000966	7525	GTEx	DepMap	Descartes	0.02	4.38
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91

B cells: Germinal center B cells (model markers)
proliferating mature B cells that undergo somatic hypermutation and class-switch recombination in secondary lymphoid organs:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.40e-01
Mean rank of genes in gene set: 5889
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
AICDA	-1.57e-05	5508	GTEx	DepMap	Descartes	0	0
BMP3	-4.58e-05	6270	GTEx	DepMap	Descartes	0	0

Monocytes: Classical monocytes (curated markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.49e-01
Mean rank of genes in gene set: 5813
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD14	-2.82e-05	5813	GTEx	DepMap	Descartes	1.83	197.54

Monocytes: Non-classical monocytes (model markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.62e-01
Mean rank of genes in gene set: 6100.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RHOC	0.0071720	71	GTEx	DepMap	Descartes	2.66	451.65
BAG3	0.0000738	4266	GTEx	DepMap	Descartes	0.18	16.44
CUX2	-0.0002013	9693	GTEx	DepMap	Descartes	0.02	0.67
ABI3	-0.0002440	10373	GTEx	DepMap	Descartes	0.17	25.68

Mast cells: Mast cells (model markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.70e-01
Mean rank of genes in gene set: 6001
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	-3.5e-05	6001	GTEx	DepMap	Descartes	0	0

Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.75e-01
Mean rank of genes in gene set: 6199.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANGPTL1	0.0013179	662	GTEx	DepMap	Descartes	0.06	4.70
NTRK2	0.0007752	1169	GTEx	DepMap	Descartes	0.27	9.47
EBF2	0.0001861	3166	GTEx	DepMap	Descartes	0.17	9.30
F10	0.0000352	4722	GTEx	DepMap	Descartes	0.04	7.90
PRRX1	0.0000242	4860	GTEx	DepMap	Descartes	0.23	14.32
SFRP1	-0.0001454	8611	GTEx	DepMap	Descartes	0.36	27.93
OLFML1	-0.0002481	10428	GTEx	DepMap	Descartes	0.05	4.08
SMOC2	-0.0003112	11077	GTEx	DepMap	Descartes	0.35	28.08
PDGFRA	-0.0003140	11099	GTEx	DepMap	Descartes	0.11	4.24

HSC/MPP: ELP (curated markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.92e-01
Mean rank of genes in gene set: 6226
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RUNX2	0.0008544	1059	GTEx	DepMap	Descartes	0.07	4.02
LTB	-0.0003536	11393	GTEx	DepMap	Descartes	0.20	46.69

ILC: NK cells (model markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.14e-01
Mean rank of genes in gene set: 6322.29
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IGFBP4	0.0044082	158	GTEx	DepMap	Descartes	4.36	631.16
CST3	0.0041104	172	GTEx	DepMap	Descartes	18.54	1771.14
MALAT1	0.0018697	458	GTEx	DepMap	Descartes	316.67	11636.64
SPINK2	-0.0001735	9174	GTEx	DepMap	Descartes	0.00	0.00
HMOX1	-0.0001862	9419	GTEx	DepMap	Descartes	0.24	29.66
KLHL23	-0.0007803	12417	GTEx	DepMap	Descartes	0.22	6.49
STMN1	-0.0008731	12458	GTEx	DepMap	Descartes	5.00	397.88

HSC/MPP: HSC/MPP (curated markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.17e-01
Mean rank of genes in gene set: 6361.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	0.0000211	4905	GTEx	DepMap	Descartes	0.38	10.98
CRHBP	0.0000126	5006	GTEx	DepMap	Descartes	0.04	3.60
SPINK2	-0.0001735	9174	GTEx	DepMap	Descartes	0.00	0.00

Myelocytes: Myelocytes (model markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.20e-01
Mean rank of genes in gene set: 6357.6
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A6	0.0112022	32	GTEx	DepMap	Descartes	25.86	14753.98
FTH1	0.0011618	754	GTEx	DepMap	Descartes	56.43	13052.39
TYROBP	-0.0000966	7523	GTEx	DepMap	Descartes	4.80	1676.03
SRGN	-0.0003339	11258	GTEx	DepMap	Descartes	3.22	540.18
ACTB	-0.0005728	12221	GTEx	DepMap	Descartes	19.08	2036.48

T cells: Type 17 helper T cells (model markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.33e-01
Mean rank of genes in gene set: 6447.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0047934	139	GTEx	DepMap	Descartes	5.58	1043.81
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91
S100A4	-0.0001989	9662	GTEx	DepMap	Descartes	3.29	1097.78

T cells: Regulatory T cells (curated markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.40e-01
Mean rank of genes in gene set: 6636
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FOXP3	-6.08e-05	6636	GTEx	DepMap	Descartes	0.01	0.24

T cells: Memory CD4+ cytotoxic T cells (curated markers)
CD4+ memory T cells which have cytotoxic activities by secreting granzymes and perforin and by killing target cells on the basis of MHC class II:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.56e-01
Mean rank of genes in gene set: 6636.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL10	0.0001369	3631	GTEx	DepMap	Descartes	0.23	20.97
CD4	-0.0001974	9642	GTEx	DepMap	Descartes	0.21	11.19

Granulocytes: Granulocytes (model markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.58e-01
Mean rank of genes in gene set: 6646.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC10A5	-5.02e-05	6383	GTEx	DepMap	Descartes	0	0
MAK	-7.24e-05	6910	GTEx	DepMap	Descartes	0	0

Mast cells: Mast cells (curated markers)
long-lived innate migrant cells found in most tissues with many large basophilic granules rich in histamine and heparin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.60e-01
Mean rank of genes in gene set: 6664
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	-3.50e-05	6001	GTEx	DepMap	Descartes	0	0
TPSB2	-8.83e-05	7327	GTEx	DepMap	Descartes	0	0

T cells: Follicular helper T cells (curated markers)
specialised CD4+ T cell subpopulation found in the periphery within B cell follicles and stimulating the cognate follicular B cells for class-switching:
Wilcoxon ranksum test P-value for gene set overrepresentation: 5.89e-01
Mean rank of genes in gene set: 6850
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CXCR5	-0.0000295	5850	GTEx	DepMap	Descartes	0	0
PDCD1	-0.0001109	7850	GTEx	DepMap	Descartes	0	0

ILC: ILC3 (curated markers)
innate lymphoid cell subpopulation III that is required for host defense against specific extracellular bacteria and fungi:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.06e-01
Mean rank of genes in gene set: 6837
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL4I1	-0.0000160	5517	GTEx	DepMap	Descartes	0.22	9.55
RORC	-0.0000483	6338	GTEx	DepMap	Descartes	0.00	0.00
KIT	-0.0001473	8656	GTEx	DepMap	Descartes	0.01	0.28

ETP: ETP (curated markers)
early thymic progenitors migrated to the thymus before turning into double-negative thymocytes or other cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.17e-01
Mean rank of genes in gene set: 7039.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD34	0.0000211	4905	GTEx	DepMap	Descartes	0.38	10.98
SPINK2	-0.0001735	9174	GTEx	DepMap	Descartes	0.00	0.00

Macrophages: Kupffer cells (curated markers)
resident macrophages in liver under non-inflammatory conditions which line the hepatic sinusoids and are involved in erythrocyte clearance:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.39e-01
Mean rank of genes in gene set: 7188
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAM1	-0.0000462	6280	GTEx	DepMap	Descartes	0.12	6.98
CD5L	-0.0001221	8096	GTEx	DepMap	Descartes	0.04	1.23

HSC/MPP: Early lymphoid/T lymphoid (model markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.41e-01
Mean rank of genes in gene set: 7578
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-9.87e-05	7578	GTEx	DepMap	Descartes	0	0

Cycling cells: Cycling B cells (model markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.48e-01
Mean rank of genes in gene set: 7071.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
RGS13	-0.0000908	7390	GTEx	DepMap	Descartes	0.01	0.19
GRIN1	-0.0003955	11649	GTEx	DepMap	Descartes	0.06	1.56

B-cell lineage: Small pre-B cells (curated markers)
non-proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.69e-01
Mean rank of genes in gene set: 7856
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0001112	7856	GTEx	DepMap	Descartes	0.02	0.86

B-cell lineage: Pro-B cells (curated markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.69e-01
Mean rank of genes in gene set: 7856
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0001112	7856	GTEx	DepMap	Descartes	0.02	0.86

Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.77e-01
Mean rank of genes in gene set: 7232.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
COL1A2	0.0020028	420	GTEx	DepMap	Descartes	5.06	280.41
COL1A1	-0.0001787	9278	GTEx	DepMap	Descartes	4.94	218.80
DCN	-0.0004754	12000	GTEx	DepMap	Descartes	5.24	206.90

T cells: Type 1 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interferon-gamma and modulating cell-mediated immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.82e-01
Mean rank of genes in gene set: 7486
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TBX21	-0.0000026	5239	GTEx	DepMap	Descartes	0.00	0.00
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08

Granulocytes: Granulocytes (curated markers)
cells of innate immune system with specific granules in the cytoplasm including neutrophils:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.90e-01
Mean rank of genes in gene set: 7313.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CPA3	-0.0000350	6001	GTEx	DepMap	Descartes	0.00	0.00
SLC45A3	-0.0000867	7283	GTEx	DepMap	Descartes	0.01	0.12
KIT	-0.0001473	8656	GTEx	DepMap	Descartes	0.01	0.28

B cells: B cells (curated markers)
B lymphocytes with diverse cell surface immunoglobulin receptors recognising specific antigenic epitopes and mediating humoral immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.96e-01
Mean rank of genes in gene set: 7587.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0000631	6676	GTEx	DepMap	Descartes	0	0
CD79A	-0.0001396	8499	GTEx	DepMap	Descartes	0	0

T cells: Tem/Effector helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.09e-01
Mean rank of genes in gene set: 7087.17
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ANXA1	0.0047934	139	GTEx	DepMap	Descartes	5.58	1043.81
DONSON	0.0000740	4263	GTEx	DepMap	Descartes	0.06	7.13
AQP3	-0.0000966	7525	GTEx	DepMap	Descartes	0.02	4.38
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91
S100A4	-0.0001989	9662	GTEx	DepMap	Descartes	3.29	1097.78
LTB	-0.0003536	11393	GTEx	DepMap	Descartes	0.20	46.69

Macrophages: Macrophages (model markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.09e-01
Mean rank of genes in gene set: 7272
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FTH1	0.0011618	754	GTEx	DepMap	Descartes	56.43	13052.39
CD5L	-0.0001221	8096	GTEx	DepMap	Descartes	0.04	1.23
APOE	-0.0002245	10072	GTEx	DepMap	Descartes	21.14	3549.03
APOC1	-0.0002308	10166	GTEx	DepMap	Descartes	6.17	1722.55

DC: DC3 (model markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.20e-01
Mean rank of genes in gene set: 7767
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0000458	6270	GTEx	DepMap	Descartes	0.00	0.00
OGDHL	-0.0001781	9264	GTEx	DepMap	Descartes	0.02	0.51

ILC precursor: ILC precursor (model markers)
innate lymphoid cell precursors which give rise to innate lymphoid cells and lack the characteristics of their mature progenies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.23e-01
Mean rank of genes in gene set: 7512.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPN	-0.0000354	6008	GTEx	DepMap	Descartes	0.00	0.00
PDZK1	-0.0000750	6985	GTEx	DepMap	Descartes	0.00	0.00
HUNK	-0.0001926	9544	GTEx	DepMap	Descartes	0.02	0.72

ILC: ILC1 (curated markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.36e-01
Mean rank of genes in gene set: 8560
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF3	-0.0001424	8560	GTEx	DepMap	Descartes	0.01	0.35

ILC: CD16- NK cells (curated markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.36e-01
Mean rank of genes in gene set: 8564
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD160	-0.0001424	8564	GTEx	DepMap	Descartes	0	0

B-cell lineage: Pre-pro-B cells (curated markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.39e-01
Mean rank of genes in gene set: 7911
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ZCCHC7	-0.0000459	6274	GTEx	DepMap	Descartes	0.16	17.90
IL7R	-0.0001928	9548	GTEx	DepMap	Descartes	0.06	3.52

T cells: Tcm/Naive helper T cells (model markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.44e-01
Mean rank of genes in gene set: 7461
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
FCGRT	0.0005624	1568	GTEx	DepMap	Descartes	2.28	221.54
CTSL	0.0000417	4647	GTEx	DepMap	Descartes	1.45	NA
LTB	-0.0003536	11393	GTEx	DepMap	Descartes	0.20	46.69
TMSB10	-0.0005837	12236	GTEx	DepMap	Descartes	41.86	23008.43

Cycling cells: Cycling NK cells (model markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.45e-01
Mean rank of genes in gene set: 7960
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KL	0.0000736	4271	GTEx	DepMap	Descartes	0.01	0.32
GRIN1	-0.0003955	11649	GTEx	DepMap	Descartes	0.06	1.56

Granulocytes: Neutrophils (curated markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.58e-01
Mean rank of genes in gene set: 8812
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
LCN2	-0.0001543	8812	GTEx	DepMap	Descartes	0	0

pDC: pDC (curated markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.69e-01
Mean rank of genes in gene set: 8936
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PLD4	-0.0001604	8936	GTEx	DepMap	Descartes	0.3	32.45

HSC/MPP: MEMP (curated markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.86e-01
Mean rank of genes in gene set: 8302.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ITGA2B	0.0000849	4154	GTEx	DepMap	Descartes	0.01	0.64
GATA2	-0.0008528	12451	GTEx	DepMap	Descartes	0.14	5.98

ILC: ILC2 (curated markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.87e-01
Mean rank of genes in gene set: 7941
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
HPGDS	0.0002901	2489	GTEx	DepMap	Descartes	0.10	16.99
KLRG1	-0.0001537	8805	GTEx	DepMap	Descartes	0.06	5.50
GATA3	-0.0012414	12529	GTEx	DepMap	Descartes	0.60	32.19

DC precursor: DC precursor (model markers)
dendritic cell precursors that differentiate into dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.95e-01
Mean rank of genes in gene set: 9264
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
OGDHL	-0.0001781	9264	GTEx	DepMap	Descartes	0.02	0.51

T cells: CD8a/a (model markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.99e-01
Mean rank of genes in gene set: 7420.43
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MALAT1	0.0018697	458	GTEx	DepMap	Descartes	316.67	11636.64
NUCB2	0.0001324	3685	GTEx	DepMap	Descartes	0.62	55.41
LEF1	-0.0000374	6051	GTEx	DepMap	Descartes	0.19	18.40
CTSW	-0.0002323	10193	GTEx	DepMap	Descartes	0.06	21.08
CD27	-0.0002434	10362	GTEx	DepMap	Descartes	0.02	7.45
PRKCH	-0.0002556	10496	GTEx	DepMap	Descartes	0.01	0.18
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

Mono-mac: Mono-mac (curated markers)
mononuclear phagocytes including monocytes and macrophages that are involved in the regulation of innate and adaptive immunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.04e-01
Mean rank of genes in gene set: 8471
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TYROBP	-0.0000966	7523	GTEx	DepMap	Descartes	4.80	1676.03
HMOX1	-0.0001862	9419	GTEx	DepMap	Descartes	0.24	29.66

pDC: pDC (model markers)
rare plasmacytoid dendritic cell subpopulation which serves as the major source of type I interferons when the body is infected by a virus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.16e-01
Mean rank of genes in gene set: 8585
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TRIM71	-0.0001132	7906	GTEx	DepMap	Descartes	0.00	0.00
OGDHL	-0.0001781	9264	GTEx	DepMap	Descartes	0.02	0.51

T cells: Tem/Temra cytotoxic T cells (model markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.17e-01
Mean rank of genes in gene set: 9548
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001928	9548	GTEx	DepMap	Descartes	0.06	3.52

Monocytes: Classical monocytes (model markers)
CD14+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.18e-01
Mean rank of genes in gene set: 8170
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD207	0.0003649	2175	GTEx	DepMap	Descartes	0.01	2.72
CST7	-0.0002064	9789	GTEx	DepMap	Descartes	0.06	31.40
EEF1A1	-0.0016840	12546	GTEx	DepMap	Descartes	39.51	2163.76

Monocyte precursor: Monocyte precursor (model markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.22e-01
Mean rank of genes in gene set: 8635.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ST18	-0.0000987	7578	GTEx	DepMap	Descartes	0.00	0.00
CUX2	-0.0002013	9693	GTEx	DepMap	Descartes	0.02	0.67

HSC/MPP: Neutrophil-myeloid progenitor (model markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.27e-01
Mean rank of genes in gene set: 9693
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CUX2	-0.0002013	9693	GTEx	DepMap	Descartes	0.02	0.67

ILC: Transitional NK (curated markers)
immature natural killer cells which originate from natural killer cell precursors and are committed to mature natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.30e-01
Mean rank of genes in gene set: 9733
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08

T cells: gamma-delta T cells (curated markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.30e-01
Mean rank of genes in gene set: 9733
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08

T cells: Tem/Effector helper T cells PD1+ (curated markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.33e-01
Mean rank of genes in gene set: 8746
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0001109	7850	GTEx	DepMap	Descartes	0.00	0.00
CD4	-0.0001974	9642	GTEx	DepMap	Descartes	0.21	11.19

DC: Migratory DCs (curated markers)
migratory dendritic cells that transport antigens to the draining lymph nodes during both homeostatic conditions and infections:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.38e-01
Mean rank of genes in gene set: 8800.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
EBI3	-0.0000493	6367	GTEx	DepMap	Descartes	0.10	16.39
CCR7	-0.0003304	11234	GTEx	DepMap	Descartes	0.02	0.95

T cells: MAIT cells (curated markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.44e-01
Mean rank of genes in gene set: 8863
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SLC4A10	-0.0001257	8185	GTEx	DepMap	Descartes	0.00	0.00
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91

T cells: Tem/Effector helper T cells PD1+ (model markers)
CD4+ helper T lymphocyte subpopulation in the thymus which features the expression of programmed cell death protein 1 (PD-1):
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.45e-01
Mean rank of genes in gene set: 8879.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
INPP5J	-0.0000513	6414	GTEx	DepMap	Descartes	0.02	2.48
PANX2	-0.0003452	11345	GTEx	DepMap	Descartes	0.02	1.55

B cells: Memory B cells (curated markers)
long-lived mature B lymphocytes which are formed within germinal centers following primary infection and selected for higher-affinity immunoglobulin:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.70e-01
Mean rank of genes in gene set: 10362
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD27	-0.0002434	10362	GTEx	DepMap	Descartes	0.02	7.45

Plasma cells: Plasma cells (model markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.77e-01
Mean rank of genes in gene set: 8371.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TGFBR3L	-0.0000484	6339	GTEx	DepMap	Descartes	0.01	NA
ST18	-0.0000987	7578	GTEx	DepMap	Descartes	0.00	0.00
MZB1	-0.0001347	8388	GTEx	DepMap	Descartes	0.04	NA
XBP1	-0.0003246	11181	GTEx	DepMap	Descartes	0.73	102.14

Macrophages: Macrophages (curated markers)
specialised mononuclear phagocytic cells which recognise:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.78e-01
Mean rank of genes in gene set: 10493
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD68	-0.0002551	10493	GTEx	DepMap	Descartes	1.68	168.02

Endothelial cells: Endothelial cells (model markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.87e-01
Mean rank of genes in gene set: 8463.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
JAM2	0.0004051	2005	GTEx	DepMap	Descartes	0.27	17.93
VWF	-0.0002058	9776	GTEx	DepMap	Descartes	0.13	1.94
MMRN2	-0.0002260	10100	GTEx	DepMap	Descartes	0.02	0.47
RAMP3	-0.0004679	11972	GTEx	DepMap	Descartes	0.06	6.33

T cells: NKT cells (curated markers)
distinct T lymphocyte subpopulation that expresses both alpha/beta T-cell receptors and surface receptors of natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.89e-01
Mean rank of genes in gene set: 10698
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

HSC/MPP: Early lymphoid/T lymphoid (curated markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.90e-01
Mean rank of genes in gene set: 9414
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
ETS1	-0.0000467	6299	GTEx	DepMap	Descartes	0.11	5.97
GATA3	-0.0012414	12529	GTEx	DepMap	Descartes	0.60	32.19

ILC: ILC2 (model markers)
innate lymphoid cell subpopulation II that promotes type 2 inflammation and is involved in immune response against large extracellular pathogens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.90e-01
Mean rank of genes in gene set: 10722
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL17RB	-0.0002741	10722	GTEx	DepMap	Descartes	0.01	0.07

T cells: MAIT cells (model markers)
mucosal-associated invariant T cells which have semi-invariant T-cell receptors and are restricted by the MHC I-like molecule MR1:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.95e-01
Mean rank of genes in gene set: 8541
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
BMP3	-0.0000458	6270	GTEx	DepMap	Descartes	0.00	0.00
KLRG1	-0.0001537	8805	GTEx	DepMap	Descartes	0.06	5.50
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91
IL7R	-0.0001928	9548	GTEx	DepMap	Descartes	0.06	3.52

B-cell lineage: Large pre-B cells (curated markers)
proliferative B lymphocyte precursors derived from Pro-B cells and expressing membrane μ chains with surrogate light chains in their receptors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.06e-01
Mean rank of genes in gene set: 9649
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MME	-0.0001112	7856	GTEx	DepMap	Descartes	0.02	0.86
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64

Plasma cells: Plasma cells (curated markers)
B-lymphocyte white blood cells capable of secreting large quantities of immunoglobulins or antibodies:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.15e-01
Mean rank of genes in gene set: 9784.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MZB1	-0.0001347	8388	GTEx	DepMap	Descartes	0.04	NA
XBP1	-0.0003246	11181	GTEx	DepMap	Descartes	0.73	102.14

Monocyte precursor: Monocyte precursor (curated markers)
monocyte precursors that are committed to the monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.16e-01
Mean rank of genes in gene set: 11266
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VCAN	-0.0003356	11266	GTEx	DepMap	Descartes	0.4	9.93

Macrophages: Hofbauer cells (model markers)
primitive placental resident macrophages with granules and vacuoles found in placenta particularly during early pregnancy:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.19e-01
Mean rank of genes in gene set: 11345
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PANX2	-0.0003452	11345	GTEx	DepMap	Descartes	0.02	1.55

Megakaryocyte precursor: Megakaryocyte precursor (curated markers)
megakaryocyte precursors in the bone marrow that are committed to megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.24e-01
Mean rank of genes in gene set: 9937
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PRSS57	-0.0000920	7423	GTEx	DepMap	Descartes	0.01	0.70
GATA2	-0.0008528	12451	GTEx	DepMap	Descartes	0.14	5.98

B cells: Follicular B cells (model markers)
resting mature B lymphocytes found in the primary and secondary lymphoid follicles and participating in T cell-dependent immune responses:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.24e-01
Mean rank of genes in gene set: 9937
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
VPREB3	-0.0001353	8408	GTEx	DepMap	Descartes	0.00	0.00
CD83	-0.0003651	11466	GTEx	DepMap	Descartes	0.96	77.69

Endothelial cells: Endothelial cells (curated markers)
single-layered lining cells that constitute the interior vasculature:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.24e-01
Mean rank of genes in gene set: 9277.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPARCL1	-0.0001192	8041	GTEx	DepMap	Descartes	1.45	101.37
PLVAP	-0.0001512	8756	GTEx	DepMap	Descartes	0.07	4.47
CLDN5	-0.0003060	11035	GTEx	DepMap	Descartes	0.25	14.93

Erythroid: Early erythroid (curated markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.28e-01
Mean rank of genes in gene set: 9324.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TESPA1	-0.0000090	5356	GTEx	DepMap	Descartes	0.02	NA
APOC1	-0.0002308	10166	GTEx	DepMap	Descartes	6.17	1722.55
GATA2	-0.0008528	12451	GTEx	DepMap	Descartes	0.14	5.98

T cells: Type 17 helper T cells (curated markers)
CD4+ helper T lymphocyte subpopulation which is capable of producing interleukin 17 (IL-17) and mediating protective immunity and autoimmunity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.31e-01
Mean rank of genes in gene set: 10065.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001928	9548	GTEx	DepMap	Descartes	0.06	3.52
ZBTB16	-0.0002624	10583	GTEx	DepMap	Descartes	0.02	0.42

T cells: CD8a/a (curated markers)
unconventional T lymphocytes with CD8 alpha/alpha homodimers binding MHC molecules:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.34e-01
Mean rank of genes in gene set: 10138.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
PDCD1	-0.0001109	7850	GTEx	DepMap	Descartes	0.00	0.00
GNG4	-0.0007965	12427	GTEx	DepMap	Descartes	0.16	3.16

T cells: Tem/Trm cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.38e-01
Mean rank of genes in gene set: 10215.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

T cells: Treg(diff) (curated markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.41e-01
Mean rank of genes in gene set: 9540.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IKZF4	-0.0000764	7025	GTEx	DepMap	Descartes	0.04	1.72
CD27	-0.0002434	10362	GTEx	DepMap	Descartes	0.02	7.45
CCR7	-0.0003304	11234	GTEx	DepMap	Descartes	0.02	0.95

DC: DC (model markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.46e-01
Mean rank of genes in gene set: 12091
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RGS1	-0.0005081	12091	GTEx	DepMap	Descartes	2.62	199.08

HSC/MPP: HSC/MPP (model markers)
hematopoietic stem cells and multipotent progenitor cells with the potential of differentiating into different blood cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.47e-01
Mean rank of genes in gene set: 10411.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
SPINK2	-0.0001735	9174	GTEx	DepMap	Descartes	0.00	0.00
GRIN1	-0.0003955	11649	GTEx	DepMap	Descartes	0.06	1.56

Epithelial cells: Epithelial cells (curated markers)
highly specialised cells which are located in the outer layer of stroma and form the cellular components of the epithelium:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.48e-01
Mean rank of genes in gene set: 12179
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KRT17	-0.000546	12179	GTEx	DepMap	Descartes	0.12	20.08

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (curated markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.56e-01
Mean rank of genes in gene set: 12451
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GATA2	-0.0008528	12451	GTEx	DepMap	Descartes	0.14	5.98

B cells: Transitional B cells (model markers)
immature B cell precursors in the bone marrow which connect Pre-B cells with mature naive B cells and are subject to the process of B cell selection:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 12486
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
GNG3	-0.0009707	12486	GTEx	DepMap	Descartes	0.38	72.93

HSC/MPP: Megakaryocyte-erythroid-mast cell progenitor (model markers)
shared progenitors in the fetal liver which originate from common myeloid progenitors and differentiate into megakaryocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.57e-01
Mean rank of genes in gene set: 12511
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CKB	-0.0010971	12511	GTEx	DepMap	Descartes	0.8	91.5

Cycling cells: Cycling B cells (curated markers)
proliferating B lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.58e-01
Mean rank of genes in gene set: 9891
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD19	-0.0000631	6676	GTEx	DepMap	Descartes	0.00	0.00
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

T cells: Trm cytotoxic T cells (model markers)
tissue resident CD8+ cytotoxic T lymphocytes mainly localized in epithelial tissues such as gut:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.62e-01
Mean rank of genes in gene set: 9993
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
IL7R	-0.0001928	9548	GTEx	DepMap	Descartes	0.06	3.52
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

T cells: Tem/Trm cytotoxic T cells (model markers)
CD8+ cytotoxic T lymphocytes mainly localized in lymphoid and peripheral tissues and presenting an immediate:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.65e-01
Mean rank of genes in gene set: 10073.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CCL5	-0.0002038	9733	GTEx	DepMap	Descartes	0.31	66.08
CST7	-0.0002064	9789	GTEx	DepMap	Descartes	0.06	31.40
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01

T cells: gamma-delta T cells (model markers)
unconventional T lymphocyte subpopulation expressing a gamma-delta T cell receptor complex on the surface to recognise antigens:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.68e-01
Mean rank of genes in gene set: 10145
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRC2	-0.0001348	8389	GTEx	DepMap	Descartes	0.00	0.00
KCNK10	-0.0002461	10397	GTEx	DepMap	Descartes	0.00	0.00
GRIN1	-0.0003955	11649	GTEx	DepMap	Descartes	0.06	1.56

Double-positive thymocytes: Double-positive thymocytes (curated markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.69e-01
Mean rank of genes in gene set: 11040.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01
SMPD3	-0.0003522	11383	GTEx	DepMap	Descartes	0.05	1.73

Cycling cells: Cycling DCs (curated markers)
proliferating dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 11498.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

Cycling cells: Cycling gamma-delta T cells (curated markers)
proliferating gamma-delta (γδ) T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 11498.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

Cycling cells: Cycling monocytes (curated markers)
proliferating monocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 11498.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

Cycling cells: Cycling NK cells (curated markers)
proliferating natural killer cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 11498.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

Cycling cells: Cycling T cells (curated markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.79e-01
Mean rank of genes in gene set: 11498.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MKI67	-0.0003609	11442	GTEx	DepMap	Descartes	0.09	0.64
TOP2A	-0.0003781	11555	GTEx	DepMap	Descartes	0.30	4.32

ILC: CD16- NK cells (model markers)
CD16- granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.80e-01
Mean rank of genes in gene set: 9098.71
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TYROBP	-0.0000966	7523	GTEx	DepMap	Descartes	4.80	1676.03
GSTP1	-0.0001288	8263	GTEx	DepMap	Descartes	4.22	655.28
FCER1G	-0.0001311	8315	GTEx	DepMap	Descartes	2.14	730.83
CLIC3	-0.0001852	9402	GTEx	DepMap	Descartes	0.07	22.73
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91
CXCL3	-0.0002044	9744	GTEx	DepMap	Descartes	0.73	91.26
LDB2	-0.0002905	10903	GTEx	DepMap	Descartes	0.10	5.58

T cells: Tcm/Naive helper T cells (curated markers)
CD4+ helper T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.84e-01
Mean rank of genes in gene set: 10749.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD4	-0.0001974	9642	GTEx	DepMap	Descartes	0.21	11.19
CCR7	-0.0003304	11234	GTEx	DepMap	Descartes	0.02	0.95
SELL	-0.0003502	11372	GTEx	DepMap	Descartes	0.12	10.35

ILC: ILC (model markers)
specialised innate immune cells from the lymphoid lineage but without antigen-specific T-cell receptors on the surface:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.86e-01
Mean rank of genes in gene set: 10278.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KLRB1	-0.0001923	9541	GTEx	DepMap	Descartes	0.13	53.91
IL7R	-0.0001928	9548	GTEx	DepMap	Descartes	0.06	3.52
AREG	-0.0002442	10377	GTEx	DepMap	Descartes	0.35	74.04
GRIN1	-0.0003955	11649	GTEx	DepMap	Descartes	0.06	1.56

T cells: Regulatory T cells (model markers)
T cell subpopulation which modulates immune responses and regulates other cells through direct cell-cell contact and cytokine release:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 10308.25
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
TIGIT	-0.0000685	6824	GTEx	DepMap	Descartes	0.01	0.21
RTKN2	-0.0003092	11060	GTEx	DepMap	Descartes	0.02	0.40
SRGN	-0.0003339	11258	GTEx	DepMap	Descartes	3.22	540.18
RGS1	-0.0005081	12091	GTEx	DepMap	Descartes	2.62	199.08

Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 11979.5
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
KCNH2	-0.0003820	11583	GTEx	DepMap	Descartes	0.04	2.12
PRDX2	-0.0007182	12376	GTEx	DepMap	Descartes	1.88	284.81

Double-positive thymocytes: Double-positive thymocytes (model markers)
immature thymocytes capable of binding MHC class I or II in the double positive (co-receptors CD4+ and CD8+) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.87e-01
Mean rank of genes in gene set: 9585.67
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
RAG2	-0.0000409	6143	GTEx	DepMap	Descartes	0.00	0.00
SH3TC1	-0.0001325	8344	GTEx	DepMap	Descartes	0.05	1.40
ARPP21	-0.0001492	8706	GTEx	DepMap	Descartes	0.02	0.74
ELOVL4	-0.0003142	11104	GTEx	DepMap	Descartes	0.04	3.91
SMPD3	-0.0003522	11383	GTEx	DepMap	Descartes	0.05	1.73
CD52	-0.0004332	11834	GTEx	DepMap	Descartes	0.32	169.57

T cells: Tcm/Naive cytotoxic T cells (curated markers)
CD8+ cytotoxic T lymphocytes mainly localized in secondary lymphoid tissues and sustaining the responses by proliferating and producing new effectors:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.89e-01
Mean rank of genes in gene set: 11101.33
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
CD8A	-0.0002724	10698	GTEx	DepMap	Descartes	0.02	3.01
CCR7	-0.0003304	11234	GTEx	DepMap	Descartes	0.02	0.95
SELL	-0.0003502	11372	GTEx	DepMap	Descartes	0.12	10.35

Double-negative thymocytes: Double-negative thymocytes (model markers)
the early immature thymocytes from the thymus in the double negative (co-receptors CD4- and CD8-) stage:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.96e-01
Mean rank of genes in gene set: 10239.83
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
MZB1	-0.0001347	8388	GTEx	DepMap	Descartes	0.04	NA
FXYD2	-0.0001349	8396	GTEx	DepMap	Descartes	0.01	0.39
MFAP4	-0.0002170	9964	GTEx	DepMap	Descartes	0.10	10.74
CD7	-0.0003282	11212	GTEx	DepMap	Descartes	0.16	25.93
SELL	-0.0003502	11372	GTEx	DepMap	Descartes	0.12	10.35
PDLIM1	-0.0005157	12107	GTEx	DepMap	Descartes	0.51	69.65

T cells: Treg(diff) (model markers)
unconventional T lymphocyte subpopulation in the thymus which connects αβ T cells and canonical regulatory T cells and is still differentiating:
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.98e-01
Mean rank of genes in gene set: 11417.75
Rank on gene expression program of genes in gene set:

Genes	Weight	Rank	GTEx	DepMap	Decartes	Mean.Counts	Mean.TPM
S100A4	-0.0001989	9662	GTEx	DepMap	Descartes	3.29	1097.78
PTPRC	-0.0004392	11864	GTEx	DepMap	Descartes	0.30	9.61
TSC22D3	-0.0004927	12054	GTEx	DepMap	Descartes	0.66	89.94
RGS1	-0.0005081	12091	GTEx	DepMap	Descartes	2.62	199.08

B cells: Naive B cells (curated markers)
mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens:
DC: DC (curated markers)
dendrite-shaped cells which process and present antigens to naïve T cells and induce adaptive immune responses :
DC: DC2 (curated markers)
conventional type 2 dendritic cells which constitute the major subset of myeloid dendritic cells:
DC: DC3 (curated markers)
a dendritic cell subtype found in bone marrow which shares features with monocytes and conventional type 2 dendritic cells:
DC precursor: DC precursor (curated markers)
dendritic cell precursors that differentiate into dendritic cells:
Erythrocytes: Erythrocytes (curated markers)
biconcave enucleated red blood cells filled with hemoglobin to transport oxygen and carbon dioxide between the lungs and tissues:
Erythroid: Late erythroid (curated markers)
late erythroid cells following early and middle erythroid cells:
HSC/MPP: CMP (curated markers)
highly proliferative common myeloid progenitors which later give rise to granulocyte-monocyte progenitors and megakaryocyte-erythroid progenitors:
HSC/MPP: GMP (curated markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: Neutrophil-myeloid progenitor (curated markers)
progenitors of neutrophils and myeloid cells which are transitioned from hematopoietic stem cells and multipotent progenitors:
ILC: CD16+ NK cells (curated markers)
CD16+ granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
ILC: NK cells (curated markers)
granular lymphocytes that play protective roles against both infectious pathogens and cancer using antibody-dependent cell-mediated cytotoxicity:
Monocytes: Non-classical monocytes (curated markers)
CD16+ myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Monocytes: Monocytes (curated markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Myelocytes: Myelocytes (curated markers)
early granulocyte precursors that are derive from promyelocytes and later mature into metamyelocytes:
Promyelocytes: Promyelocytes (curated markers)
early granulocyte progenitors in the bone marrow which are derived from the myeloblasts and develop into the myelocytes:
T cells: Tem/Temra cytotoxic T cells (curated markers)
terminally differentiated CD8+ cytotoxic T lymphocytes with effector memory phenotypes that re-express CD45RA :
B-cell lineage: Pre-pro-B cells (model markers)
the earliest primitive B cell progenitors which express CD34 and SPINK2:
B-cell lineage: Pro-B cells (model markers)
early B lymphocyte progenitors undergoing D-J joining on the H chain chromosome and joining of a V segment to the rearranged D-J:
Cycling cells: Cycling gamma-delta T cells (model markers)
proliferating gamma-delta (γδ) T lymphocytes:
Cycling cells: Cycling monocytes (model markers)
proliferating monocytes:
DC: Transitional DC (model markers)
immature dendritic cells which follow dendritic cell precursors and are committed to the mature dendritic cells:
Erythroid: Mid erythroid (model markers)
middle erythroid cells in fetal liver:
Granulocytes: Neutrophils (model markers)
the most abundant type of granulocytes that contains distinctive cytoplasmic granules and forms an essential part of the innate immune system:
HSC/MPP: ELP (model markers)
early lymphoid progenitors which originate from hematopoietic stem cells of the bone marrow and migrate to the thymus:
HSC/MPP: GMP (model markers)
hematopoietic granulocyte-monocyte progenitors that are committed to the granulocyte and monocyte lineage cells:
HSC/MPP: MEMP (model markers)
shared progenitors which are derived from common myeloid progenitors and will differentiate into megakaryocytes:
ILC: ILC1 (model markers)
innate lymphoid cell subpopulation I that is non-cytotoxic and has overlapping phenotypes and functions with natural killer cells:
Macrophages: Kidney-resident macrophages (model markers)
long-lived macrophages resident in the kidney under non-inflammatory conditions and maintaining homeostasis and resolving inflammation :
Megakaryocytes/platelets: Megakaryocytes/platelets (model markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
MNP: MNP (model markers)
mononuclear phagocytes including dendritic cells: