Program: 51. Adrenergic Neuroblastoma (HTA4_1021).

Program: 51. Adrenergic Neuroblastoma (HTA4_1021).


Program description and justification of annotation generated by GPT5: MYCN/2p24 amplicon-associated ribosome/translation program in adrenergic malignant neuroblastoma (immature-adrenergic bias).

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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 DDX1 0.0091640 DEAD-box helicase 1 GTEx DepMap Descartes 163.96 26972.11
2 NBAS 0.0077821 NBAS subunit of NRZ tethering complex GTEx DepMap Descartes 103.01 6670.62
3 RPS19 0.0062551 ribosomal protein S19 GTEx DepMap Descartes 18.69 4359.82
4 RPS4X 0.0048275 ribosomal protein S4 X-linked GTEx DepMap Descartes 11.23 2840.93
5 RPS18 0.0047243 ribosomal protein S18 GTEx DepMap Descartes 19.83 7989.20
6 MYCN 0.0047126 MYCN proto-oncogene, bHLH transcription factor GTEx DepMap Descartes 8.27 1356.75
7 RPS3 0.0045218 ribosomal protein S3 GTEx DepMap Descartes 11.22 2399.71
8 RPS21 0.0045117 ribosomal protein S21 GTEx DepMap Descartes 13.83 5663.70
9 FAM149A 0.0044969 family with sequence similarity 149 member A GTEx DepMap Descartes 1.19 196.46
10 RPS7 0.0043685 ribosomal protein S7 GTEx DepMap Descartes 12.27 1020.96
11 BARHL1 0.0041660 BarH like homeobox 1 GTEx DepMap Descartes 0.26 62.88
12 RPL18A 0.0041528 ribosomal protein L18a GTEx DepMap Descartes 8.63 2823.21
13 RPL29 0.0041066 ribosomal protein L29 GTEx DepMap Descartes 8.20 4191.85
14 RPL13 0.0040243 ribosomal protein L13 GTEx DepMap Descartes 22.83 2335.79
15 RBFOX3 0.0039278 RNA binding fox-1 homolog 3 GTEx DepMap Descartes 3.36 493.90
16 RPS3A 0.0039080 ribosomal protein S3A GTEx DepMap Descartes 11.41 3428.71
17 RPL3 0.0038809 ribosomal protein L3 GTEx DepMap Descartes 12.19 2532.20
18 RPL26 0.0038591 ribosomal protein L26 GTEx DepMap Descartes 4.66 2249.57
19 RPL32 0.0038348 ribosomal protein L32 GTEx DepMap Descartes 10.04 2296.74
20 MEIS2 0.0038289 Meis homeobox 2 GTEx DepMap Descartes 10.63 851.79
21 RPL37A 0.0037988 ribosomal protein L37a GTEx DepMap Descartes 14.40 2237.87
22 RPL7A 0.0037891 ribosomal protein L7a GTEx DepMap Descartes 9.13 3423.24
23 SLC17A6 0.0037742 solute carrier family 17 member 6 GTEx DepMap Descartes 0.34 46.46
24 RPL10A 0.0037272 ribosomal protein L10a GTEx DepMap Descartes 5.34 2299.08
25 RPL10 0.0036415 ribosomal protein L10 GTEx DepMap Descartes 12.37 2359.85
26 RPS24 0.0036296 ribosomal protein S24 GTEx DepMap Descartes 16.26 2349.58
27 RACK1 0.0036252 receptor for activated C kinase 1 GTEx DepMap Descartes 6.62 NA
28 RPL14 0.0035953 ribosomal protein L14 GTEx DepMap Descartes 6.85 426.07
29 RPL41 0.0035654 ribosomal protein L41 GTEx DepMap Descartes 7.83 5080.30
30 RPL34 0.0035628 ribosomal protein L34 GTEx DepMap Descartes 10.43 1855.74
31 RPS14 0.0035152 ribosomal protein S14 GTEx DepMap Descartes 10.65 1554.28
32 RPS2 0.0034056 ribosomal protein S2 GTEx DepMap Descartes 12.13 3476.69
33 RPS28 0.0033236 ribosomal protein S28 GTEx DepMap Descartes 6.15 1799.48
34 MT-CO3 0.0032798 NA GTEx DepMap Descartes 66.59 28869.60
35 EEF1B2 0.0032776 eukaryotic translation elongation factor 1 beta 2 GTEx DepMap Descartes 3.94 1677.17
36 RPS6 0.0032537 ribosomal protein S6 GTEx DepMap Descartes 7.52 2512.06
37 ADARB2 0.0031767 adenosine deaminase RNA specific B2 (inactive) GTEx DepMap Descartes 7.31 399.67
38 RPL5 0.0031574 ribosomal protein L5 GTEx DepMap Descartes 6.99 2569.84
39 RPL9 0.0031513 ribosomal protein L9 GTEx DepMap Descartes 7.59 1490.88
40 EEF1A1 0.0031235 eukaryotic translation elongation factor 1 alpha 1 GTEx DepMap Descartes 10.61 1059.66
41 RPL35A 0.0031192 ribosomal protein L35a GTEx DepMap Descartes 6.42 2384.21
42 RPL21 0.0030734 ribosomal protein L21 GTEx DepMap Descartes 6.10 3440.56
43 RPS16 0.0030532 ribosomal protein S16 GTEx DepMap Descartes 6.03 1176.93
44 RPL36 0.0030400 ribosomal protein L36 GTEx DepMap Descartes 9.07 4723.93
45 RPL4 0.0030100 ribosomal protein L4 GTEx DepMap Descartes 4.84 811.19
46 INSM1 0.0030086 INSM transcriptional repressor 1 GTEx DepMap Descartes 0.99 162.50
47 MT-CO2 0.0030081 NA GTEx DepMap Descartes 39.74 19339.18
48 NECTIN4 0.0029759 nectin cell adhesion molecule 4 GTEx DepMap Descartes 0.38 NA
49 NHLH2 0.0029646 nescient helix-loop-helix 2 GTEx DepMap Descartes 0.42 27.23
50 RPS27 0.0029564 ribosomal protein S27 GTEx DepMap Descartes 7.66 5803.47


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UMAP plots showing activity of gene expression program identified in GEP 51. Adrenergic Neuroblastoma (HTA4_1021):

Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 51. Adrenergic Neuroblastoma (HTA4_1021):
Interactive Boxplot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
BUSSLINGER_GASTRIC_PPP1R1B_POSITIVE_CELLS 1.52e-63 454.60 235.37 5.10e-61 1.02e-60
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPS16, RPL36, RPL4, RPS27
 121
BUSSLINGER_GASTRIC_LYZ_POSITIVE_CELLS 1.15e-59 414.61 218.43 1.93e-57 7.71e-57
31RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL36, RPS27
 111
RUBENSTEIN_SKELETAL_MUSCLE_T_CELLS 1.49e-64 362.72 185.94 1.00e-61 1.00e-61
36RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 181
RUBENSTEIN_SKELETAL_MUSCLE_B_CELLS 6.73e-60 303.05 160.09 1.50e-57 4.51e-57
34RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPL36, RPL4, RPS27
 177
TRAVAGLINI_LUNG_CD4_NAIVE_T_CELL 1.22e-49 250.52 133.66 1.03e-47 8.21e-47
28RPS19, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL10A, RPL10, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, EEF1A1, RPL35A, RPS16, RPL36, RPL4, RPS27
 132
BUSSLINGER_DUODENAL_TRANSIT_AMPLIFYING_CELLS 5.12e-56 246.87 130.24 5.73e-54 3.44e-53
33RPS19, RPS4X, RPS18, RPS3, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPS16, RPL36, RPL4
 194
RUBENSTEIN_SKELETAL_MUSCLE_SATELLITE_CELLS 7.20e-58 213.56 109.61 9.67e-56 4.83e-55
37RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, MT-CO3, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 310
FAN_OVARY_CL0_XBP1_SELK_HIGH_STROMAL_CELL 6.18e-44 189.20 101.70 3.77e-42 4.14e-41
26RPS19, RPS4X, RPS18, RPS3, RPL18A, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS6, RPL5, RPL9, RPL35A, RPL21, RPL36, RPS27
 143
TRAVAGLINI_LUNG_CLUB_CELL 9.92e-40 192.70 101.15 3.70e-38 6.66e-37
23RPS19, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL26, RPL32, RPL37A, RPL10, RPS24, RPL34, RPS14, RPS28, RPS6, RPL5, RPL35A, RPL21, RPS16, RPL36, RPS27
 114
LAKE_ADULT_KIDNEY_C7_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S3 4.19e-40 169.77 90.60 1.76e-38 2.81e-37
24RPS19, RPS4X, RPS18, RPS21, RPS7, RPL13, RPS3A, RPL3, RPL32, RPL37A, RPL7A, RPS24, RPL14, RPL34, RPS14, RPS28, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL4
 135
TRAVAGLINI_LUNG_BRONCHIAL_VESSEL_1_CELL 4.78e-47 158.47 85.49 3.21e-45 3.21e-44
30RPS19, RPS4X, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 224
BUSSLINGER_DUODENAL_DIFFERENTIATING_STEM_CELLS 2.36e-51 160.47 85.30 2.27e-49 1.59e-48
34RPS19, RPS4X, RPS18, RPS3, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPS16, RPL36, RPL4, RPS27
 305
BUSSLINGER_DUODENAL_STEM_CELLS 6.95e-49 143.03 76.42 5.18e-47 4.66e-46
33RPS19, RPS4X, RPS18, RPS3, RPS7, RPL18A, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPS16, RPL36, RPL4, RPS27
 311
LAKE_ADULT_KIDNEY_C8_DECENDING_THIN_LIMB 4.88e-42 113.77 61.64 2.52e-40 3.27e-39
29RPS19, RPS4X, RPS18, RPS7, RPL13, RPS3A, RPL3, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL21, RPS16, RPL4, RPS27
 278
LAKE_ADULT_KIDNEY_C19_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_A_MEDULLA 5.61e-42 103.99 56.50 2.69e-40 3.77e-39
30RPS19, RPS4X, RPS18, RPS3, RPS7, RPL13, RPS3A, RPL3, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL4, RPS27
 326
LAKE_ADULT_KIDNEY_C9_THIN_ASCENDING_LIMB 1.83e-36 91.66 49.89 6.14e-35 1.23e-33
26RPS19, RPS4X, RPS18, RPS3, RPS7, RPL13, RPS3A, RPL3, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL34, RPS14, RPS2, RPS6, RPL5, RPL9, EEF1A1, RPL21, RPS16, RPL4
 268
HAY_BONE_MARROW_NAIVE_T_CELL 4.15e-41 89.90 48.79 1.86e-39 2.78e-38
31RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL32, RPL10A, RPL10, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 403
LAKE_ADULT_KIDNEY_C18_COLLECTING_DUCT_PRINCIPAL_CELLS_MEDULLA 3.56e-38 88.79 48.40 1.26e-36 2.39e-35
28RPS19, RPS4X, RPS18, RPS7, RPL13, RPS3A, RPL3, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, EEF1A1, RPL21, RPS16, RPL4, RPS27
 322
LAKE_ADULT_KIDNEY_C12_THICK_ASCENDING_LIMB 6.50e-40 87.73 47.72 2.56e-38 4.36e-37
30RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL13, RPS3A, RPL3, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS28, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL4, RPS27
 381
TRAVAGLINI_LUNG_PROXIMAL_BASAL_CELL 1.93e-42 80.58 42.71 1.08e-40 1.30e-39
35RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, MEIS2, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4
 629

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_MYC_TARGETS_V1 4.84e-07 17.32 6.49 2.42e-05 2.42e-05
7RPS3, RACK1, RPL14, RPL34, RPS2, EEF1B2, RPS6
 200
HALLMARK_P53_PATHWAY 1.23e-02 6.65 1.31 2.06e-01 6.17e-01
3RACK1, RPL36, NHLH2
 200
HALLMARK_ALLOGRAFT_REJECTION 1.23e-02 6.65 1.31 2.06e-01 6.17e-01
3RPS19, RPS3A, RPL9
 200
HALLMARK_PANCREAS_BETA_CELLS 9.26e-02 10.74 0.26 1.00e+00 1.00e+00
1INSM1
 40
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 2.40e-01 3.74 0.09 1.00e+00 1.00e+00
1RPS14
 113
HALLMARK_G2M_CHECKPOINT 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1MEIS2
 200
HALLMARK_APICAL_JUNCTION 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1NECTIN4
 200
HALLMARK_KRAS_SIGNALING_UP 3.84e-01 2.11 0.05 1.00e+00 1.00e+00
1MYCN
 200
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_MITOTIC_SPINDLE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 199
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 87
HALLMARK_DNA_REPAIR 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 150
HALLMARK_APOPTOSIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 161
HALLMARK_NOTCH_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 32
HALLMARK_ADIPOGENESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_RIBOSOME 3.71e-66 639.25 331.50 6.90e-64 6.90e-64
32RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 88
KEGG_CARDIAC_MUSCLE_CONTRACTION 1.57e-02 11.11 1.29 1.00e+00 1.00e+00
2MT-CO3, MT-CO2
 79
KEGG_PARKINSONS_DISEASE 3.94e-02 6.68 0.78 1.00e+00 1.00e+00
2MT-CO3, MT-CO2
 130
KEGG_OXIDATIVE_PHOSPHORYLATION 4.05e-02 6.58 0.77 1.00e+00 1.00e+00
2MT-CO3, MT-CO2
 132
KEGG_ALZHEIMERS_DISEASE 6.07e-02 5.22 0.61 1.00e+00 1.00e+00
2MT-CO3, MT-CO2
 166
KEGG_HUNTINGTONS_DISEASE 7.12e-02 4.75 0.56 1.00e+00 1.00e+00
2MT-CO3, MT-CO2
 182
KEGG_MTOR_SIGNALING_PATHWAY 1.19e-01 8.21 0.20 1.00e+00 1.00e+00
1RPS6
 52
KEGG_ADHERENS_JUNCTION 1.62e-01 5.82 0.14 1.00e+00 1.00e+00
1NECTIN4
 73
KEGG_INSULIN_SIGNALING_PATHWAY 2.83e-01 3.08 0.08 1.00e+00 1.00e+00
1RPS6
 137
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_GLYCEROLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 49
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 25
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 77
KEGG_ETHER_LIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 33
KEGG_ARACHIDONIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 58
KEGG_LINOLEIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 29

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2p24 7.66e-04 18.45 3.59 2.13e-01 2.13e-01
3DDX1, NBAS, MYCN
 74
MT 3.63e-03 24.43 2.77 5.05e-01 1.00e+00
2MT-CO3, MT-CO2
 37
chr19p13 4.29e-01 1.70 0.34 1.00e+00 1.00e+00
3RPL18A, RPS28, RPL36
 773
chr9q34 1.70e-01 2.77 0.32 1.00e+00 1.00e+00
2BARHL1, RPL7A
 311
chr6p21 3.05e-01 1.84 0.22 1.00e+00 1.00e+00
2RPS18, RPL10A
 467
chr11p14 1.27e-01 7.62 0.19 1.00e+00 1.00e+00
1SLC17A6
 56
chr15q14 1.27e-01 7.62 0.19 1.00e+00 1.00e+00
1MEIS2
 56
chr6q13 1.27e-01 7.62 0.19 1.00e+00 1.00e+00
1EEF1A1
 56
chr4p14 1.44e-01 6.65 0.16 1.00e+00 1.00e+00
1RPL9
 64
chr10p15 1.88e-01 4.93 0.12 1.00e+00 1.00e+00
1ADARB2
 86
chr4q25 1.90e-01 4.87 0.12 1.00e+00 1.00e+00
1RPL34
 87
chr4q35 2.25e-01 4.03 0.10 1.00e+00 1.00e+00
1FAM149A
 105
chr5q33 2.32e-01 3.88 0.10 1.00e+00 1.00e+00
1RPS14
 109
chr2p25 2.47e-01 3.61 0.09 1.00e+00 1.00e+00
1RPS7
 117
chr19q13 1.00e+00 0.74 0.09 1.00e+00 1.00e+00
2RPS19, RPS16
 1165
chr3q29 2.56e-01 3.46 0.09 1.00e+00 1.00e+00
1RPL35A
 122
chr15q22 2.60e-01 3.41 0.08 1.00e+00 1.00e+00
1RPL4
 124
chr2q35 2.63e-01 3.35 0.08 1.00e+00 1.00e+00
1RPL37A
 126
chr1p22 2.69e-01 3.27 0.08 1.00e+00 1.00e+00
1RPL5
 129
chr16q24 2.70e-01 3.25 0.08 1.00e+00 1.00e+00
1RPL13
 130

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
ZZZ3_TARGET_GENES 2.68e-13 46.26 20.08 4.34e-11 3.04e-10
10RPS18, RPS3, RPS7, RPS3A, RPL37A, RPL10A, RPL41, RPS14, RPS2, RPL35A
 121
TAF9B_TARGET_GENES 6.85e-25 35.04 19.13 7.76e-22 7.76e-22
24DDX1, RPS4X, RPS3, RPL29, RPL3, RPL26, MEIS2, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS28, RPS6, RPL5, EEF1A1, RPL35A, RPL4, RPS27
 565
PER1_TARGET_GENES 1.19e-06 61.45 15.09 7.92e-05 1.35e-03
4RPL3, RPL34, EEF1A1, RPL21
 33
ZNF318_TARGET_GENES 3.13e-17 24.22 12.70 1.77e-14 3.55e-14
18RPS18, RPS3, RPS7, RPL29, RPL13, RPS3A, RPL26, RPL32, RPL37A, RPL7A, RPS24, RACK1, RPL41, RPL34, RPS14, RPL5, EEF1A1, RPL4
 495
FOXR2_TARGET_GENES 1.84e-10 22.92 10.09 2.08e-08 2.08e-07
10RPS18, RPS21, RPL32, RACK1, RPL34, RPS14, RPS6, EEF1A1, RPS16, RPS27
 234
HJURP_TARGET_GENES 4.21e-05 52.28 9.78 1.71e-03 4.78e-02
3RPL3, RACK1, EEF1A1
 28
GTF2A2_TARGET_GENES 3.54e-14 19.10 9.78 8.01e-12 4.01e-11
16RPS18, RPS3, RPS7, RPL29, RPL13, RPS3A, RPL3, RPL37A, RPL10, RPS24, RPS2, RPS6, EEF1A1, RPL36, RPL4, RPS27
 522
FOXE1_TARGET_GENES 1.22e-15 17.76 9.43 4.61e-13 1.38e-12
19RPS4X, RPS3, BARHL1, RPL29, RPL13, RPL3, RPL26, RPL32, RPL10A, RPS24, RPL41, RPS14, RPS28, RPS6, RPL5, RPL9, RPL4, INSM1, RPS27
 728
SNRNP70_TARGET_GENES 2.54e-14 13.85 7.43 7.19e-12 2.88e-11
20RPS19, RPS3, RPL13, RPL3, RPL26, RPL32, RPL7A, RPL10, RPS24, RACK1, RPL41, RPS14, RPS2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPS16, MT-CO2
 1009
ADA2_TARGET_GENES 4.23e-11 11.64 5.98 5.98e-09 4.79e-08
16DDX1, RPS18, RPS3, RPS7, RPL29, RPL13, RPS3A, RPL3, RPL32, MEIS2, RPS24, RPS14, RPS2, RPL5, RPL9, EEF1A1
 846
NFRKB_TARGET_GENES 1.16e-13 10.43 5.72 2.18e-11 1.31e-10
24DDX1, NBAS, RPS19, RPS18, RPS3, RPS7, RPL29, RPS3A, RPL3, RPL26, RPL32, RPS24, RACK1, RPL14, RPL41, RPL34, EEF1B2, RPS6, RPL9, RPL35A, RPL21, RPL36, RPL4, RPS27
 1843
KAT5_TARGET_GENES 1.19e-10 10.81 5.55 1.50e-08 1.35e-07
16DDX1, RPL18A, RPL13, RPL32, RPL37A, RPL10A, RPL10, RPS24, RPL34, RPS14, MT-CO3, EEF1B2, RPS6, RPL5, EEF1A1, RPL36
 910
CAGNWMCNNNGAC_UNKNOWN 6.08e-05 21.24 5.43 2.15e-03 6.89e-02
4BARHL1, SLC17A6, RPL4, NHLH2
 88
PSMB5_TARGET_GENES 6.23e-07 13.08 5.26 4.71e-05 7.06e-04
8RPL3, RPL32, RPL10A, RPL10, RPS2, RPS28, EEF1A1, RPS27
 307
SETD7_TARGET_GENES 3.82e-09 9.02 4.56 3.61e-07 4.33e-06
15RPS19, RPL13, RPS3A, RPL3, RPL26, MEIS2, RPL10, RACK1, RPL14, RPS14, RPS2, RPS6, RPL5, EEF1A1, RPL4
 991
KAT2A_TARGET_GENES 3.30e-09 8.48 4.35 3.40e-07 3.74e-06
16DDX1, RPS4X, RPS3, RPS7, RPL29, RPL3, RPL7A, RACK1, RPL41, RPL34, RPS2, RPL5, RPL9, RPL35A, RPS16, RPL36
 1157
TMTCGCGANR_UNKNOWN 4.88e-05 14.17 4.33 1.88e-03 5.53e-02
5RPS19, RPS7, RPL26, RPL10A, RPS6
 166
AUTS2_TARGET_GENES 1.02e-06 10.20 4.33 7.19e-05 1.15e-03
9RPS19, MYCN, RPL26, RACK1, RPS28, RPL5, RPL9, RPL4, INSM1
 451
TET1_TARGET_GENES 5.32e-08 8.57 4.17 4.63e-06 6.02e-05
13DDX1, RPS19, RPS7, RPL18A, RPL29, RPS3A, RPL3, RPL10A, RPS24, RPS28, RPS6, RPL5, RPL35A
 855
GGCNKCCATNK_UNKNOWN 2.08e-04 15.26 3.93 6.03e-03 2.35e-01
4RPL18A, RPL32, RPL4, RPS27
 121

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 1.34e-65 538.00 275.82 5.00e-62 9.99e-62
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 107
GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 2.34e-66 503.83 258.42 1.75e-62 1.75e-62
34NBAS, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 120
GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 1.52e-63 454.60 235.37 3.79e-60 1.14e-59
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 121
GOBP_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 3.66e-60 341.56 180.96 6.84e-57 2.74e-56
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 149
GOBP_TRANSLATIONAL_INITIATION 1.66e-58 274.32 143.81 2.48e-55 1.24e-54
34DDX1, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 193
GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS 2.58e-57 251.83 131.28 3.22e-54 1.93e-53
34NBAS, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 208
GOBP_VIRAL_GENE_EXPRESSION 1.06e-55 240.96 127.31 1.13e-52 7.92e-52
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 198
GOBP_PROTEIN_TARGETING_TO_MEMBRANE 6.07e-55 226.30 120.07 5.67e-52 4.54e-51
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 208
GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE 3.26e-49 137.14 73.09 2.71e-46 2.44e-45
34RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 351
GOBP_RNA_CATABOLIC_PROCESS 9.95e-47 115.19 61.03 7.45e-44 7.45e-43
34NBAS, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 414
GOBP_PROTEIN_TARGETING 7.03e-44 98.63 52.80 4.78e-41 5.26e-40
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 438
GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS 9.41e-44 83.28 43.01 5.87e-41 7.04e-40
37DDX1, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 740
GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE 5.79e-40 73.32 39.45 2.55e-37 4.33e-36
33RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 576
GOBP_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS 2.23e-40 72.34 38.61 1.04e-37 1.67e-36
34NBAS, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 637
GOBP_PROTEIN_LOCALIZATION_TO_MEMBRANE 6.59e-40 69.89 37.38 2.74e-37 4.93e-36
34RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 658
GOBP_AMIDE_BIOSYNTHETIC_PROCESS 4.24e-41 69.78 36.05 2.44e-38 3.17e-37
37DDX1, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 877
GOBP_MRNA_METABOLIC_PROCESS 4.60e-41 69.61 35.96 2.46e-38 3.44e-37
37DDX1, NBAS, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RBFOX3, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, ADARB2, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 879
GOBP_PEPTIDE_METABOLIC_PROCESS 1.20e-40 67.69 34.96 6.01e-38 9.01e-37
37DDX1, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, EEF1B2, RPS6, RPL5, RPL9, EEF1A1, RPL35A, RPL21, RPS16, RPL36, RPL4, RPS27
 903
GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_SYMBIOTIC_INTERACTION 2.30e-37 55.01 28.83 9.07e-35 1.72e-33
36DDX1, RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL29, RPL13, RPS3A, RPL3, RPL26, RPL32, RPL37A, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, RPS28, RPS6, RPL5, RPL9, RPL35A, RPL21, RPS16, RPL36, RPL4, NECTIN4, RPS27
 997
GOBP_CYTOPLASMIC_TRANSLATION 7.66e-16 63.56 28.43 1.64e-13 5.73e-12
11RPS21, RPL18A, RPL29, RPL26, RPL32, RPL10A, RPL41, RPS28, RPL9, RPL35A, RPL36
 102

Dowload full table

Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 3.54e-44 151.48 81.77 1.73e-40 1.73e-40
28RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL13, RPS3A, RPL3, RPL26, RPL37A, RPL7A, RPL10, RACK1, RPL14, RPL41, RPL34, RPS14, RPS2, EEF1B2, RPS6, RPL5, RPL9, RPS16, RPL36, RPL4, RPS27
 200
GSE2405_0H_VS_9H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN 5.13e-42 138.95 75.21 1.25e-38 2.50e-38
27RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPL18A, RPL13, RPS3A, RPL3, RPL26, RPL37A, RPL7A, RPL10, RACK1, RPL14, RPL34, RPS14, RPS2, EEF1B2, RPS6, RPL5, RPL9, RPS16, RPL36, RPL4, RPS27
 200
GSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN 4.71e-26 69.47 36.38 7.65e-23 2.30e-22
19RPS4X, RPS18, RPS3, RPS7, RPL13, RPS3A, RPL3, RPL26, RPL37A, RPL10, RACK1, RPL41, RPL34, RPS14, RPS6, RPL5, RPL9, RPS16, RPL4
 200
GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP 2.89e-24 63.79 33.09 3.08e-21 1.41e-20
18RPS19, RPS18, RPS7, RPL26, RPL37A, RPL7A, RPL10, RPS24, RACK1, RPL41, RPL34, RPS14, RPS6, RPL9, RPL35A, RPL21, RPS16, RPS27
 199
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_2H_DN 3.16e-24 63.45 32.89 3.08e-21 1.54e-20
18RPS18, RPS7, RPL29, RPL13, RPL26, RPL32, RPL7A, RPL10A, RPL10, RPS24, RACK1, RPL14, RPS28, RPL35A, RPL21, RPS16, RPL36, RPL4
 200
GSE41978_KLRG1_HIGH_VS_LOW_EFFECTOR_CD8_TCELL_DN 1.94e-22 57.69 29.60 1.58e-19 9.46e-19
17RPS19, RPS4X, RPS18, RPS3, RPS21, RPS7, RPS3A, RPL3, RPL7A, RPL10, RPL34, RPS14, RPS2, RPS6, RPL5, RPL9, RPS16
 200
GSE22886_NAIVE_TCELL_VS_DC_UP 1.00e-20 52.75 26.70 6.97e-18 4.88e-17
16RPS18, RPS3, RPS7, RPL29, RPL3, RPL26, RPL7A, RPL14, RPL34, RPS14, EEF1B2, RPL5, RPL35A, RPL21, RPL36, RPS27
 199
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_4H_DN 5.12e-19 47.74 23.82 3.12e-16 2.49e-15
15RPS19, RPS4X, RPS18, RPS7, RPL13, RPL26, RPL32, RPL10, RPS24, RACK1, RPL34, RPS14, RPL35A, RPL21, RPS16
 199
GSE42724_NAIVE_VS_B1_BCELL_DN 2.38e-17 43.13 21.13 1.29e-14 1.16e-13
14RPS3, RPS7, RPL29, RPL13, RPL3, RPL26, RPL7A, RACK1, RPL34, RPS2, EEF1B2, RPS6, RPL5, RPL4
 199
GSE3720_UNSTIM_VS_LPS_STIM_VD2_GAMMADELTA_TCELL_UP 4.61e-15 41.77 19.51 2.04e-12 2.24e-11
12RPS19, RPS3, RPL29, RPL3, RPL32, RPL37A, RPL14, RPS2, EEF1B2, RPL5, RPL36, RPL4
 167
GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_UP 9.32e-16 38.98 18.70 4.54e-13 4.54e-12
13RPS18, RPS3, RPL13, RPS3A, RPL32, RPL7A, RPL10, RACK1, RPS14, EEF1B2, RPL5, RPL21, RPL4
 198
GSE3720_UNSTIM_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_UP 8.08e-15 39.71 18.57 3.28e-12 3.94e-11
12RPS3, RPL29, RPL3, RPL32, RPL37A, RPL10A, RPS2, EEF1B2, EEF1A1, RPL36, RPL4, RPS27
 175
GSE14000_TRANSLATED_RNA_VS_MRNA_DC_DN 2.77e-14 35.61 16.66 1.04e-11 1.35e-10
12RPS18, RPS3, RPL26, RPL32, RPL10, RACK1, RPS14, EEF1B2, RPS6, RPL21, RPL36, RPL4
 194
GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_UP 3.98e-14 34.48 16.13 1.39e-11 1.94e-10
12RPS3, RPS7, RPL29, RPL13, RPS3A, RPL3, RPL7A, EEF1B2, RPL5, RPL35A, RPL21, RPL4
 200
GSE6269_HEALTHY_VS_FLU_INF_PBMC_UP 3.32e-13 35.08 15.92 1.08e-10 1.62e-09
11RPL18A, RPL13, RPS3A, RPL3, RPL10A, RPL10, RPS14, RPS28, EEF1B2, RPL5, RPL4
 176
GSE6269_FLU_VS_E_COLI_INF_PBMC_DN 5.65e-12 33.32 14.59 1.62e-09 2.75e-08
10MYCN, RPL29, RPL13, RPS3A, RPL3, RPL10, RPS14, EEF1B2, RPL5, RPL4
 164
GSE10239_NAIVE_VS_DAY4.5_EFF_CD8_TCELL_UP 1.27e-12 30.80 14.01 3.85e-10 6.17e-09
11RPS18, RPS3, RPS21, RPS7, RPL13, RPL26, RPL32, RPL37A, RPS14, EEF1B2, RPL36
 199
GSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN 9.21e-10 23.97 10.09 2.23e-07 4.49e-06
9RPS19, RPS18, RPS7, RPL13, RPL26, RPL32, RPL10A, RPS6, RPS27
 197
GSE2124_CTRL_VS_LYMPHOTOXIN_BETA_TREATED_MLN_UP 9.21e-10 23.97 10.09 2.23e-07 4.49e-06
9RPS4X, RPS7, RPS3A, RPL26, RPS14, RPS6, RPL5, RPL9, RPS16
 197
GSE3982_NEUTROPHIL_VS_BCELL_DN 9.63e-10 23.84 10.05 2.23e-07 4.69e-06
9RPS19, RPS4X, RPS18, RPL13, RPL32, RPL9, RPL35A, RPS16, RPS27
 198

Dowload full table

Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol Gene Loading Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
MYCN 6 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
BARHL1 11 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
MEIS2 20 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RPL7A 22 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
INSM1 46 Yes Known motif Monomer or homomultimer In vivo/Misc source None None
NHLH2 49 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
RPL7 72 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA by filter binding (PMID: 8441630), but competition assays suggest it is non-specific. A specific dsRNA structure is thought to be the preferred substrate. RNA-binding has been demonstrated by gel-shift experiments (PMID: 10329420).
RPS27A 79 No ssDNA/RNA binding Not a DNA binding protein No motif None None
EBF3 81 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
SATB2 92 Yes Inferred motif Low specificity DNA-binding protein In vivo/Misc source None SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).
DACH1 94 Yes Likely to be sequence specific TF Monomer or homomultimer No motif Has a putative AT-hook Binds with consensus AAWANAAAWAAWT and AATACAATTAAAT as strongest target sequences based on EMSA and SELEX (PMID: 20351289). Protein contains a winged helix structural domain (PMID: 12057194)
NFIX 102 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
NPM1 104 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for sequence-specific DNA-binding (PMID: 2223875)
EDA2R 116 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Included only because GO says positive regulation of sequence-specific DNA binding transcription factor activity. Not DNA binding.
POU4F1 117 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
ZFHX4 124 Yes Inferred motif Monomer or homomultimer In vivo/Misc source None Curious protein with numerous C2H2 and homeodomain-like domains.
SOX11 130 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
NPAS4 173 Yes Inferred motif Obligate heteromer High-throughput in vitro None Likely dimerizes with ARNT2 (PMID:24263188).
UBA52 174 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
POU4F2 182 Yes Known motif Monomer or homomultimer High-throughput in vitro None None

Druggable Genes for this Gene Expression Program:

Gene Symbol Gene Loading Rank Drug Names Drug Category GTEx DepMap
CACNA2D1 74
4BEPRIDIL, GABAPENTIN ENACARBIL, GABAPENTIN, PREGABALIN
 Small molecule GTEx DepMap
IMPDH2 91
3MYCOPHENOLATE MOFETIL, MYCOPHENOLIC ACID, THIOGUANINE
 Small molecule GTEx DepMap
KCNN4 100
1CHLORZOXAZONE
 Small molecule GTEx DepMap
ERBB4 108
3AFATINIB, OSIMERTINIB, VANDETANIB
 Small molecule GTEx DepMap
PRKCE 119
1(7S)-HYDROXYL-STAUROSPORINE
 Small molecule GTEx DepMap
TUBB2B 151
9VINCRISTINE, VINORELBINE BASE, ERIBULIN, CABAZITAXEL, IXABEPILONE, DOCETAXEL, COLCHICINE, PACLITAXEL, VINBLASTINE
 Small molecule GTEx DepMap
TUBB2B 151
2BRENTUXIMAB VEDOTIN, TRASTUZUMAB EMTANSINE
 Antibody GTEx DepMap
RYR3 231
1DANTROLENE
 Small molecule GTEx DepMap
ODC1 250
1EFLORNITHINE
 Small molecule GTEx DepMap
GRIN1 287
6MEMANTINE, KETAMINE, ORPHENADRINE, ACAMPROSATE, AMANTADINE, FELBAMATE
 Small molecule GTEx DepMap
GRIA4 289
2PERAMPANEL, TOPIRAMATE
 Small molecule GTEx DepMap
EPHA7 292
1VANDETANIB
 Small molecule GTEx DepMap
KCNH8 310
2GUANIDINE, DALFAMPRIDINE
 Small molecule GTEx DepMap
P2RX3 341
1AF-219
 Small molecule GTEx DepMap
PRKCA 382
1(7S)-HYDROXYL-STAUROSPORINE
 Small molecule GTEx DepMap
KCNQ2 429
3GUANIDINE, DALFAMPRIDINE, EZOGABINE
 Small molecule GTEx DepMap
BRD3 440
1GSK525762
 Small molecule GTEx DepMap
TNFRSF10B 498
1TIGATUZUMAB
 Antibody GTEx DepMap
FYN 521
1DASATINIB
 Small molecule GTEx DepMap
MDM2 530
1AMG232
 Small molecule GTEx DepMap
IDH2 547
1ENASIDENIB
 Small molecule GTEx DepMap


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
AAACGCTTCTTCTGTA-1_HTA4_1021_4082 Neurons 0.30 4233.03
Raw ScoresNeurons: 0.53, Astrocyte: 0.47, Neuroepithelial_cell: 0.47, Embryonic_stem_cells: 0.41, iPS_cells: 0.4, MSC: 0.35, Smooth_muscle_cells: 0.33, Fibroblasts: 0.33, Tissue_stem_cells: 0.32, Osteoblasts: 0.32
GATCAGTTCAAGCCTA-1_HTA4_1021_4082 Neurons 0.28 3859.04
Raw ScoresNeurons: 0.52, Neuroepithelial_cell: 0.49, Astrocyte: 0.46, Embryonic_stem_cells: 0.43, iPS_cells: 0.41, MSC: 0.35, Tissue_stem_cells: 0.32, Endothelial_cells: 0.31, Fibroblasts: 0.3, Smooth_muscle_cells: 0.28
CCGTGAGCACAGCTTA-1_HTA4_1021_4082 Neurons 0.28 3748.62
Raw ScoresNeurons: 0.51, Astrocyte: 0.46, Neuroepithelial_cell: 0.46, Embryonic_stem_cells: 0.4, iPS_cells: 0.39, MSC: 0.34, Smooth_muscle_cells: 0.33, Fibroblasts: 0.33, Osteoblasts: 0.32, Chondrocytes: 0.32
GGAGGATCACGTAGTT-1_HTA4_1021_4082 Neurons 0.29 3495.56
Raw ScoresNeurons: 0.56, Neuroepithelial_cell: 0.51, Astrocyte: 0.49, Embryonic_stem_cells: 0.46, iPS_cells: 0.45, MSC: 0.39, Endothelial_cells: 0.35, Tissue_stem_cells: 0.34, Fibroblasts: 0.33, Smooth_muscle_cells: 0.33
CGGTCAGAGGCCTGCT-1_HTA4_1021_4082 Neurons 0.29 3438.63
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.47, Astrocyte: 0.47, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.36, Fibroblasts: 0.33, Tissue_stem_cells: 0.32, Smooth_muscle_cells: 0.32, Endothelial_cells: 0.31
TCTCAGCGTTGCGAAG-1_HTA4_1021_4082 Neurons 0.28 3400.70
Raw ScoresNeurons: 0.52, Neuroepithelial_cell: 0.46, Astrocyte: 0.45, Embryonic_stem_cells: 0.4, iPS_cells: 0.39, MSC: 0.35, Smooth_muscle_cells: 0.34, Fibroblasts: 0.33, Tissue_stem_cells: 0.33, Osteoblasts: 0.32
GGGCTCATCGACATCA-1_HTA4_1021_4083 Neurons 0.29 3071.65
Raw ScoresNeurons: 0.55, Neuroepithelial_cell: 0.5, Astrocyte: 0.47, Embryonic_stem_cells: 0.44, iPS_cells: 0.43, MSC: 0.38, Tissue_stem_cells: 0.34, Endothelial_cells: 0.33, Fibroblasts: 0.33, Smooth_muscle_cells: 0.32
ACCGTTCGTGGAACAC-1_HTA4_1021_4082 Neurons 0.27 3021.97
Raw ScoresNeurons: 0.5, Astrocyte: 0.44, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.38, iPS_cells: 0.37, MSC: 0.32, Smooth_muscle_cells: 0.32, Fibroblasts: 0.32, Osteoblasts: 0.31, Tissue_stem_cells: 0.31
TGATTCTGTTCTTGTT-1_HTA4_1021_4082 Neurons 0.28 2906.29
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.47, Astrocyte: 0.45, Embryonic_stem_cells: 0.42, iPS_cells: 0.4, MSC: 0.35, Tissue_stem_cells: 0.32, Smooth_muscle_cells: 0.32, Fibroblasts: 0.32, Endothelial_cells: 0.32
ACGGTCGCAGCATTGT-1_HTA4_1021_4082 Neurons 0.28 2851.70
Raw ScoresNeurons: 0.51, Astrocyte: 0.44, Neuroepithelial_cell: 0.44, Embryonic_stem_cells: 0.38, iPS_cells: 0.37, MSC: 0.33, Smooth_muscle_cells: 0.33, Fibroblasts: 0.32, Chondrocytes: 0.31, Osteoblasts: 0.31
GGAGAACGTGACAACG-1_HTA4_1021_4082 Neurons 0.29 2735.80
Raw ScoresNeurons: 0.52, Neuroepithelial_cell: 0.47, Astrocyte: 0.46, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.36, Tissue_stem_cells: 0.32, Fibroblasts: 0.32, Endothelial_cells: 0.31, Smooth_muscle_cells: 0.31
TGACCCTCATACCATG-1_HTA4_1021_4082 Neurons 0.27 2727.62
Raw ScoresNeurons: 0.49, Neuroepithelial_cell: 0.44, Astrocyte: 0.43, Embryonic_stem_cells: 0.39, iPS_cells: 0.37, MSC: 0.31, Smooth_muscle_cells: 0.28, Endothelial_cells: 0.28, Fibroblasts: 0.28, Tissue_stem_cells: 0.28
AATGCCACATCAGCGC-1_HTA4_1021_4082 Neurons 0.29 2688.86
Raw ScoresNeurons: 0.51, Astrocyte: 0.44, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.38, iPS_cells: 0.37, MSC: 0.33, Smooth_muscle_cells: 0.32, Fibroblasts: 0.32, Tissue_stem_cells: 0.31, Osteoblasts: 0.3
TTCGATTCAACCCGCA-1_HTA4_1021_4082 Neurons 0.28 2654.86
Raw ScoresNeurons: 0.52, Neuroepithelial_cell: 0.47, Astrocyte: 0.45, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.35, Tissue_stem_cells: 0.31, Endothelial_cells: 0.31, Fibroblasts: 0.31, Smooth_muscle_cells: 0.3
CGGAATTCACACGCCA-1_HTA4_1021_4082 Neurons 0.30 2644.11
Raw ScoresNeurons: 0.54, Neuroepithelial_cell: 0.48, Astrocyte: 0.48, Embryonic_stem_cells: 0.43, iPS_cells: 0.41, MSC: 0.36, Tissue_stem_cells: 0.32, Endothelial_cells: 0.31, Smooth_muscle_cells: 0.31, Fibroblasts: 0.31
TACCTCGTCTGCTAGA-1_HTA4_1021_4082 Neurons 0.28 2589.69
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.47, Astrocyte: 0.47, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.36, Smooth_muscle_cells: 0.34, Fibroblasts: 0.34, Tissue_stem_cells: 0.33, Endothelial_cells: 0.33
CTCAGTCAGGCCACCT-1_HTA4_1021_4082 Neurons 0.28 2484.35
Raw ScoresNeurons: 0.48, Neuroepithelial_cell: 0.43, Astrocyte: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.31, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3, Osteoblasts: 0.29, Tissue_stem_cells: 0.29
CCCTCTCAGTTACGAA-1_HTA4_1021_4082 Neurons 0.28 2471.95
Raw ScoresNeurons: 0.54, Neuroepithelial_cell: 0.5, Astrocyte: 0.46, Embryonic_stem_cells: 0.45, iPS_cells: 0.43, MSC: 0.36, Tissue_stem_cells: 0.32, Endothelial_cells: 0.32, Fibroblasts: 0.3, MEP: 0.3
CCCTCTCTCAAGCCAT-1_HTA4_1021_4082 Neurons 0.27 2411.42
Raw ScoresNeurons: 0.47, Astrocyte: 0.43, Neuroepithelial_cell: 0.42, Embryonic_stem_cells: 0.36, iPS_cells: 0.36, MSC: 0.32, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3, Osteoblasts: 0.29, Tissue_stem_cells: 0.29
CAACGATTCCCTTGTG-1_HTA4_1021_4082 Neurons 0.29 2379.61
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.48, Astrocyte: 0.44, Embryonic_stem_cells: 0.43, iPS_cells: 0.41, MSC: 0.35, Endothelial_cells: 0.31, Tissue_stem_cells: 0.31, MEP: 0.29, Fibroblasts: 0.29
GGTTAACAGACATATG-1_HTA4_1021_4082 Neurons 0.28 2339.88
Raw ScoresNeurons: 0.48, Astrocyte: 0.43, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.32, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3, Tissue_stem_cells: 0.29, Osteoblasts: 0.29
CCGAACGCACTCCACT-1_HTA4_1021_4082 Neurons 0.27 2317.74
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.45, Astrocyte: 0.43, Embryonic_stem_cells: 0.4, iPS_cells: 0.39, MSC: 0.34, Tissue_stem_cells: 0.31, Fibroblasts: 0.3, Endothelial_cells: 0.3, Smooth_muscle_cells: 0.3
GACCAATTCCCGATCT-1_HTA4_1021_4082 Neurons 0.28 2230.53
Raw ScoresNeurons: 0.5, Astrocyte: 0.45, Neuroepithelial_cell: 0.44, Embryonic_stem_cells: 0.39, iPS_cells: 0.38, MSC: 0.33, Fibroblasts: 0.33, Smooth_muscle_cells: 0.33, Osteoblasts: 0.32, Tissue_stem_cells: 0.31
ATTCCTACACGACGCT-1_HTA4_1021_4082 Neurons 0.27 2228.85
Raw ScoresNeurons: 0.46, Neuroepithelial_cell: 0.41, Astrocyte: 0.41, Embryonic_stem_cells: 0.35, iPS_cells: 0.34, MSC: 0.3, Smooth_muscle_cells: 0.29, Fibroblasts: 0.29, Chondrocytes: 0.28, Osteoblasts: 0.28
CCGCAAGGTCGCTGCA-1_HTA4_1021_4082 Neurons 0.25 2213.65
Raw ScoresNeurons: 0.44, Neuroepithelial_cell: 0.4, Astrocyte: 0.4, Embryonic_stem_cells: 0.36, iPS_cells: 0.35, MSC: 0.28, Fibroblasts: 0.28, Smooth_muscle_cells: 0.27, Osteoblasts: 0.27, Tissue_stem_cells: 0.26
AGCCAGCGTCTAACGT-1_HTA4_1021_4082 Neurons 0.29 2204.50
Raw ScoresNeurons: 0.48, Astrocyte: 0.43, Neuroepithelial_cell: 0.42, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.32, Fibroblasts: 0.31, Smooth_muscle_cells: 0.3, Osteoblasts: 0.29, Chondrocytes: 0.28
GCCATGGTCGAAACAA-1_HTA4_1021_4082 Neurons 0.28 2173.01
Raw ScoresNeurons: 0.46, Astrocyte: 0.43, Neuroepithelial_cell: 0.42, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.32, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3, Osteoblasts: 0.29, Tissue_stem_cells: 0.28
GGTGAAGGTTCAGGTT-1_HTA4_1021_4082 Neurons 0.28 2128.53
Raw ScoresNeurons: 0.46, Astrocyte: 0.4, Neuroepithelial_cell: 0.4, Embryonic_stem_cells: 0.34, iPS_cells: 0.33, MSC: 0.3, Smooth_muscle_cells: 0.29, Fibroblasts: 0.28, Osteoblasts: 0.27, Tissue_stem_cells: 0.27
GACATCATCGTTCATT-1_HTA4_1021_4082 Neurons 0.27 2122.94
Raw ScoresNeurons: 0.46, Neuroepithelial_cell: 0.41, Astrocyte: 0.41, Embryonic_stem_cells: 0.36, iPS_cells: 0.34, MSC: 0.3, Smooth_muscle_cells: 0.29, Fibroblasts: 0.28, Tissue_stem_cells: 0.28, Osteoblasts: 0.27
TGGAACTAGTAATCCC-1_HTA4_1021_4083 Neurons 0.28 2103.02
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.42, Astrocyte: 0.42, Embryonic_stem_cells: 0.38, iPS_cells: 0.37, MSC: 0.31, Smooth_muscle_cells: 0.31, Fibroblasts: 0.3, Tissue_stem_cells: 0.3, Osteoblasts: 0.3
TCGATTTAGTTCGGTT-1_HTA4_1021_4082 Neurons 0.27 2096.01
Raw ScoresNeurons: 0.47, Astrocyte: 0.43, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.38, iPS_cells: 0.37, MSC: 0.32, Fibroblasts: 0.32, Smooth_muscle_cells: 0.3, Osteoblasts: 0.3, Chondrocytes: 0.3
TGCTTGCCATGACAAA-1_HTA4_1021_4083 Neurons 0.29 2068.12
Raw ScoresNeurons: 0.49, Astrocyte: 0.43, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.31, Smooth_muscle_cells: 0.3, Fibroblasts: 0.29, Tissue_stem_cells: 0.29, Endothelial_cells: 0.29
TCATATCCATCGGTTA-1_HTA4_1021_4083 Neurons 0.28 2050.92
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.45, Astrocyte: 0.44, Embryonic_stem_cells: 0.4, iPS_cells: 0.39, MSC: 0.33, Endothelial_cells: 0.3, Tissue_stem_cells: 0.3, Smooth_muscle_cells: 0.29, Fibroblasts: 0.28
CAGCCAGTCGTCTACC-1_HTA4_1021_4082 Neurons 0.28 2036.71
Raw ScoresNeurons: 0.49, Astrocyte: 0.45, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.38, iPS_cells: 0.36, Fibroblasts: 0.33, MSC: 0.33, Smooth_muscle_cells: 0.32, Osteoblasts: 0.32, Chondrocytes: 0.31
GATTCGATCTGCATGA-1_HTA4_1021_4082 Neurons 0.28 2031.20
Raw ScoresNeurons: 0.52, Neuroepithelial_cell: 0.47, Astrocyte: 0.45, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.35, Endothelial_cells: 0.31, Tissue_stem_cells: 0.31, Fibroblasts: 0.29, MEP: 0.29
TGGTTAGGTATCAAGA-1_HTA4_1021_4082 Neurons 0.29 1995.68
Raw ScoresNeurons: 0.47, Astrocyte: 0.41, Neuroepithelial_cell: 0.41, Embryonic_stem_cells: 0.36, iPS_cells: 0.35, MSC: 0.3, Smooth_muscle_cells: 0.29, Fibroblasts: 0.29, Tissue_stem_cells: 0.28, Osteoblasts: 0.27
TTCTAACAGCTACGTT-1_HTA4_1021_4082 Neurons 0.26 1964.49
Raw ScoresNeurons: 0.45, Neuroepithelial_cell: 0.4, Astrocyte: 0.39, Embryonic_stem_cells: 0.36, iPS_cells: 0.35, MSC: 0.29, Smooth_muscle_cells: 0.27, Fibroblasts: 0.26, Tissue_stem_cells: 0.25, Osteoblasts: 0.25
CTACTATGTCGCCACA-1_HTA4_1021_4082 Neurons 0.27 1946.07
Raw ScoresNeurons: 0.48, Astrocyte: 0.43, Neuroepithelial_cell: 0.42, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.33, Fibroblasts: 0.32, Smooth_muscle_cells: 0.32, Tissue_stem_cells: 0.31, Osteoblasts: 0.31
TTACCGCAGATAGTCA-1_HTA4_1021_4082 Neurons 0.27 1930.08
Raw ScoresNeurons: 0.48, Astrocyte: 0.44, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.33, Fibroblasts: 0.32, Smooth_muscle_cells: 0.32, Endothelial_cells: 0.31, Osteoblasts: 0.31
CCTCTCCGTTCTGAGT-1_HTA4_1021_4082 Neurons 0.27 1898.72
Raw ScoresNeurons: 0.49, Astrocyte: 0.43, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.32, Fibroblasts: 0.31, Smooth_muscle_cells: 0.31, Osteoblasts: 0.3, Chondrocytes: 0.29
AATGACCGTTGTCTAG-1_HTA4_1021_4082 Neurons 0.28 1893.94
Raw ScoresNeurons: 0.49, Neuroepithelial_cell: 0.44, Astrocyte: 0.43, Embryonic_stem_cells: 0.39, iPS_cells: 0.38, MSC: 0.33, Endothelial_cells: 0.31, Tissue_stem_cells: 0.29, Fibroblasts: 0.29, Smooth_muscle_cells: 0.29
ACGATCAAGTCGCTAT-1_HTA4_1021_4082 Neurons 0.25 1879.12
Raw ScoresNeurons: 0.45, Neuroepithelial_cell: 0.41, Astrocyte: 0.41, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.31, Smooth_muscle_cells: 0.28, Fibroblasts: 0.28, Endothelial_cells: 0.28, Tissue_stem_cells: 0.28
ATCGTGAGTGTCTAAC-1_HTA4_1021_4083 Neurons 0.30 1868.99
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.46, Astrocyte: 0.45, Embryonic_stem_cells: 0.41, iPS_cells: 0.4, MSC: 0.33, Tissue_stem_cells: 0.3, Endothelial_cells: 0.29, Fibroblasts: 0.28, MEP: 0.27
AGAACCTCATTCCTCG-1_HTA4_1021_4082 Neurons 0.28 1868.00
Raw ScoresNeurons: 0.47, Neuroepithelial_cell: 0.43, Astrocyte: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.32, Smooth_muscle_cells: 0.31, Fibroblasts: 0.31, Tissue_stem_cells: 0.3, Osteoblasts: 0.3
AAATGGATCGTCGACG-1_HTA4_1021_4082 Neurons 0.25 1862.99
Raw ScoresNeurons: 0.42, Neuroepithelial_cell: 0.36, Astrocyte: 0.36, Embryonic_stem_cells: 0.33, iPS_cells: 0.31, MSC: 0.27, Smooth_muscle_cells: 0.26, Fibroblasts: 0.26, Osteoblasts: 0.25, Tissue_stem_cells: 0.24
CCGGACACAGAGTTCT-1_HTA4_1021_4083 Neurons 0.29 1861.92
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.45, Astrocyte: 0.43, Embryonic_stem_cells: 0.39, iPS_cells: 0.37, MSC: 0.31, Tissue_stem_cells: 0.28, Fibroblasts: 0.28, Endothelial_cells: 0.28, Smooth_muscle_cells: 0.27
TAGTGCATCCCTCTTT-1_HTA4_1021_4082 Neurons 0.29 1858.56
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.49, Astrocyte: 0.46, Embryonic_stem_cells: 0.44, iPS_cells: 0.42, MSC: 0.35, Tissue_stem_cells: 0.31, Endothelial_cells: 0.31, Fibroblasts: 0.29, MEP: 0.29
TGGTTAGGTTACAGCT-1_HTA4_1021_4082 Neurons 0.29 1839.26
Raw ScoresNeurons: 0.48, Neuroepithelial_cell: 0.42, Astrocyte: 0.42, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.31, Smooth_muscle_cells: 0.3, Fibroblasts: 0.3, Osteoblasts: 0.29, Tissue_stem_cells: 0.29
TGCTTGCTCACTTCTA-1_HTA4_1021_4083 Neurons 0.29 1822.13
Raw ScoresNeurons: 0.47, Astrocyte: 0.43, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.32, Smooth_muscle_cells: 0.31, Fibroblasts: 0.31, Osteoblasts: 0.3, Chondrocytes: 0.29
ATTCCATGTGCCTGCA-1_HTA4_1021_4082 Neurons 0.29 1799.70
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.45, Astrocyte: 0.44, Embryonic_stem_cells: 0.38, iPS_cells: 0.37, MSC: 0.33, Smooth_muscle_cells: 0.31, Fibroblasts: 0.31, Tissue_stem_cells: 0.31, Osteoblasts: 0.31


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Translation (Dong)
Markers obtained in computationally inferred meta program (by NMF applied to their neuroblastoma sc-RNA-seq data) from Fig. 5(a) of Dong et al. (PMID 32946775).:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.70e-03
Mean rank of genes in gene set: 243
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
EIF3L 0.0011974 166 GTEx DepMap Descartes 2.03 266.35
EIF3E 0.0010086 210 GTEx DepMap Descartes 2.11 440.31
EIF3F 0.0007067 353 GTEx DepMap Descartes 1.02 55.16


Definitive Zone (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Definitive Zone subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.20e-03
Mean rank of genes in gene set: 2462.5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CPE 0.0013131 143 GTEx DepMap Descartes 3.89 641.77
GREB1 0.0006002 451 GTEx DepMap Descartes 2.04 91.40
CALN1 0.0000625 3915 GTEx DepMap Descartes 4.02 158.71
CHCHD10 0.0000182 5341 GTEx DepMap Descartes 0.48 131.29


p53 Dependent Senescence (Kinker)
These marker genes were obtained in a pan cancer cell lines NMF analysis of scRNA-eq data in Kinker et al (PMID 33128048) - 10 metaprograms were recovered that manifest across cancers.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.12e-02
Mean rank of genes in gene set: 700
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CDKN1A 0.0006930 364 GTEx DepMap Descartes 0.31 69.22
TP53I3 0.0003221 1036 GTEx DepMap Descartes 0.15 36.98




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.02e-01
Mean rank of genes in gene set: 10130.78
Median rank of genes in gene set: 10830
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
INSM1 0.0030086 46 GTEx DepMap Descartes 0.99 162.50
PRSS12 0.0025636 66 GTEx DepMap Descartes 2.35 207.49
DACH1 0.0018763 94 GTEx DepMap Descartes 5.74 467.71
FAM155A 0.0017074 103 GTEx DepMap Descartes 42.63 1819.92
DLK1 0.0016306 111 GTEx DepMap Descartes 3.15 323.84
SOX11 0.0014479 130 GTEx DepMap Descartes 3.97 185.63
EYA1 0.0014353 131 GTEx DepMap Descartes 4.90 463.59
TUBB2B 0.0012655 151 GTEx DepMap Descartes 4.27 914.44
EEF1A2 0.0012363 154 GTEx DepMap Descartes 2.85 285.62
SLC10A4 0.0012199 157 GTEx DepMap Descartes 0.83 165.60
HS6ST2 0.0012160 159 GTEx DepMap Descartes 3.41 328.06
DCX 0.0012100 161 GTEx DepMap Descartes 1.93 86.94
CCNI 0.0011485 172 GTEx DepMap Descartes 3.08 470.93
NCAN 0.0011081 180 GTEx DepMap Descartes 0.77 49.59
DUSP4 0.0009930 216 GTEx DepMap Descartes 0.46 36.78
RBMS3 0.0009664 220 GTEx DepMap Descartes 7.13 326.13
GPR22 0.0009082 238 GTEx DepMap Descartes 0.47 68.17
ISL1 0.0008740 251 GTEx DepMap Descartes 1.87 322.21
RNF144A 0.0008104 288 GTEx DepMap Descartes 3.30 223.53
CDC42EP3 0.0008087 291 GTEx DepMap Descartes 0.76 60.19
CACNA2D2 0.0007934 293 GTEx DepMap Descartes 0.47 31.93
ATCAY 0.0007850 299 GTEx DepMap Descartes 1.76 136.27
MXI1 0.0007609 308 GTEx DepMap Descartes 1.89 217.77
BEND4 0.0007454 321 GTEx DepMap Descartes 0.24 11.60
CKB 0.0007084 351 GTEx DepMap Descartes 1.43 399.73
TRAP1 0.0006902 367 GTEx DepMap Descartes 1.66 286.79
RALGDS 0.0006834 376 GTEx DepMap Descartes 0.96 63.10
NCAM1 0.0006595 393 GTEx DepMap Descartes 12.20 763.25
GDAP1L1 0.0006367 412 GTEx DepMap Descartes 0.94 133.27
LRRTM2 0.0006294 419 GTEx DepMap Descartes 0.36 24.96


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15223.49
Median rank of genes in gene set: 17413.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EGR1 0.0009053 239 GTEx DepMap Descartes 1.27 163.68
CYP26A1 0.0005748 477 GTEx DepMap Descartes 0.02 3.45
RIN2 0.0005019 572 GTEx DepMap Descartes 1.14 101.34
ADGRG6 0.0004145 743 GTEx DepMap Descartes 0.21 NA
F2R 0.0003963 786 GTEx DepMap Descartes 0.36 39.44
LAPTM4A 0.0003942 792 GTEx DepMap Descartes 0.78 223.00
LIPA 0.0003499 936 GTEx DepMap Descartes 1.16 178.64
PDIA6 0.0003464 947 GTEx DepMap Descartes 0.91 132.54
RCN1 0.0003015 1125 GTEx DepMap Descartes 0.28 44.15
MBTPS1 0.0002926 1175 GTEx DepMap Descartes 0.99 85.54
SOX9 0.0002668 1321 GTEx DepMap Descartes 0.09 9.16
JAM3 0.0002542 1395 GTEx DepMap Descartes 1.41 143.83
PHLDA3 0.0002439 1464 GTEx DepMap Descartes 0.16 23.98
FZD2 0.0002280 1580 GTEx DepMap Descartes 0.05 5.82
ITPRIPL2 0.0002216 1627 GTEx DepMap Descartes 0.18 10.39
ANTXR1 0.0002104 1716 GTEx DepMap Descartes 1.72 108.73
PXDN 0.0002077 1740 GTEx DepMap Descartes 1.25 67.54
SSBP4 0.0002020 1795 GTEx DepMap Descartes 0.69 140.33
DDR2 0.0001984 1840 GTEx DepMap Descartes 0.68 25.87
COL6A1 0.0001970 1853 GTEx DepMap Descartes 0.80 70.10
PRDX4 0.0001868 1944 GTEx DepMap Descartes 0.29 112.33
NBR1 0.0001580 2258 GTEx DepMap Descartes 0.80 63.85
SSR1 0.0001537 2302 GTEx DepMap Descartes 0.57 22.36
HOMER1 0.0001333 2563 GTEx DepMap Descartes 0.99 56.03
MYDGF 0.0001311 2603 GTEx DepMap Descartes 0.35 NA
RECK 0.0001304 2617 GTEx DepMap Descartes 0.74 63.75
ATP8B2 0.0001285 2647 GTEx DepMap Descartes 0.65 41.16
SLC30A1 0.0001075 2978 GTEx DepMap Descartes 0.06 4.09
HS3ST3A1 0.0001038 3036 GTEx DepMap Descartes 0.16 14.52
EGR3 0.0001030 3055 GTEx DepMap Descartes 0.09 7.67


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15588.58
Median rank of genes in gene set: 18061
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HSPD1 0.0005481 510 GTEx DepMap Descartes 2.50 435.56
IGF1R 0.0004127 748 GTEx DepMap Descartes 6.64 210.38
FDXR 0.0003738 837 GTEx DepMap Descartes 0.19 32.71
HSPE1 0.0002726 1289 GTEx DepMap Descartes 0.69 396.46
SCAP 0.0001080 2966 GTEx DepMap Descartes 0.79 66.46
TM7SF2 -0.0000061 7948 GTEx DepMap Descartes 0.20 34.82
GSTA4 -0.0000194 9691 GTEx DepMap Descartes 0.64 138.87
PEG3 -0.0000581 12451 GTEx DepMap Descartes 0.01 NA
FREM2 -0.0000842 13730 GTEx DepMap Descartes 0.01 0.19
JAKMIP2 -0.0000867 13855 GTEx DepMap Descartes 2.17 83.61
INHA -0.0000893 13952 GTEx DepMap Descartes 0.02 4.31
SLC2A14 -0.0001178 15125 GTEx DepMap Descartes 0.03 2.43
SLC16A9 -0.0001363 15761 GTEx DepMap Descartes 0.51 43.61
BAIAP2L1 -0.0001394 15868 GTEx DepMap Descartes 0.11 10.01
DHCR7 -0.0001439 16016 GTEx DepMap Descartes 0.09 10.37
SULT2A1 -0.0001637 16580 GTEx DepMap Descartes 0.01 1.80
CYP11A1 -0.0001764 16869 GTEx DepMap Descartes 0.14 14.17
MC2R -0.0002064 17567 GTEx DepMap Descartes 0.04 2.03
SCARB1 -0.0002147 17722 GTEx DepMap Descartes 1.60 87.01
CYP17A1 -0.0002160 17747 GTEx DepMap Descartes 0.07 6.39
SLC1A2 -0.0002178 17795 GTEx DepMap Descartes 1.13 32.82
APOC1 -0.0002243 17936 GTEx DepMap Descartes 0.06 32.44
PAPSS2 -0.0002318 18061 GTEx DepMap Descartes 0.25 15.76
CYP11B1 -0.0002330 18078 GTEx DepMap Descartes 0.26 12.90
NPC1 -0.0002419 18227 GTEx DepMap Descartes 0.50 34.89
SH3BP5 -0.0002544 18412 GTEx DepMap Descartes 0.88 76.35
FRMD5 -0.0002549 18420 GTEx DepMap Descartes 4.97 355.13
STAR -0.0002557 18436 GTEx DepMap Descartes 0.17 10.36
GRAMD1B -0.0002604 18506 GTEx DepMap Descartes 1.43 52.71
CYB5B -0.0002625 18536 GTEx DepMap Descartes 0.51 42.13


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15095.07
Median rank of genes in gene set: 19300
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
EYA1 0.0014353 131 GTEx DepMap Descartes 4.90 463.59
TUBB2B 0.0012655 151 GTEx DepMap Descartes 4.27 914.44
ISL1 0.0008740 251 GTEx DepMap Descartes 1.87 322.21
STMN4 0.0005601 493 GTEx DepMap Descartes 1.51 257.55
GAL 0.0002986 1135 GTEx DepMap Descartes 2.11 1016.01
MAB21L2 0.0001429 2437 GTEx DepMap Descartes 0.37 59.34
CCND1 0.0001303 2622 GTEx DepMap Descartes 3.11 290.95
PTCHD1 0.0001302 2623 GTEx DepMap Descartes 0.91 23.50
CNTFR 0.0000731 3632 GTEx DepMap Descartes 0.66 120.66
ELAVL2 0.0000498 4244 GTEx DepMap Descartes 2.24 198.48
HMX1 0.0000407 4533 GTEx DepMap Descartes 0.86 160.71
GREM1 -0.0001566 16378 GTEx DepMap Descartes 0.05 0.75
MLLT11 -0.0001632 16566 GTEx DepMap Descartes 0.99 150.21
RPH3A -0.0002376 18157 GTEx DepMap Descartes 0.24 12.52
NTRK1 -0.0002402 18199 GTEx DepMap Descartes 0.31 27.36
TMEM132C -0.0002499 18351 GTEx DepMap Descartes 7.59 568.70
BASP1 -0.0002672 18588 GTEx DepMap Descartes 2.86 572.40
RGMB -0.0002759 18699 GTEx DepMap Descartes 0.60 45.16
MAP1B -0.0002760 18701 GTEx DepMap Descartes 8.94 246.70
PRPH -0.0002839 18798 GTEx DepMap Descartes 1.16 188.35
MAB21L1 -0.0003127 19107 GTEx DepMap Descartes 0.25 27.67
GAP43 -0.0003349 19300 GTEx DepMap Descartes 2.21 391.92
TUBA1A -0.0003715 19588 GTEx DepMap Descartes 5.81 1048.66
CNKSR2 -0.0003879 19697 GTEx DepMap Descartes 2.46 107.69
STMN2 -0.0004322 19925 GTEx DepMap Descartes 6.52 1105.57
TUBB2A -0.0004432 19972 GTEx DepMap Descartes 0.85 136.29
EYA4 -0.0004751 20084 GTEx DepMap Descartes 1.00 55.96
REEP1 -0.0004924 20133 GTEx DepMap Descartes 1.12 78.87
HS3ST5 -0.0005063 20168 GTEx DepMap Descartes 0.74 49.49
PLXNA4 -0.0005219 20204 GTEx DepMap Descartes 1.84 38.75


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13672.59
Median rank of genes in gene set: 14810
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
IRX3 0.0002926 1172 GTEx DepMap Descartes 0.03 5.23
CYP26B1 0.0001985 1839 GTEx DepMap Descartes 0.05 4.25
HYAL2 0.0001252 2693 GTEx DepMap Descartes 0.16 13.82
PODXL 0.0000715 3672 GTEx DepMap Descartes 0.24 14.57
RAMP2 0.0000486 4281 GTEx DepMap Descartes 0.14 60.99
TMEM88 0.0000130 5552 GTEx DepMap Descartes 0.04 16.93
TEK 0.0000005 6361 GTEx DepMap Descartes 0.12 8.70
ECSCR -0.0000060 7933 GTEx DepMap Descartes 0.00 0.00
KANK3 -0.0000610 12591 GTEx DepMap Descartes 0.03 5.00
F8 -0.0000669 12904 GTEx DepMap Descartes 0.09 3.57
SHANK3 -0.0000695 13032 GTEx DepMap Descartes 0.27 11.00
ESM1 -0.0000722 13172 GTEx DepMap Descartes 0.02 3.65
CDH13 -0.0000746 13297 GTEx DepMap Descartes 1.71 75.03
NPR1 -0.0000841 13726 GTEx DepMap Descartes 0.01 0.80
FCGR2B -0.0000871 13872 GTEx DepMap Descartes 0.00 0.33
GALNT15 -0.0000919 14065 GTEx DepMap Descartes 0.06 NA
SOX18 -0.0000975 14304 GTEx DepMap Descartes 0.01 2.21
ROBO4 -0.0000980 14330 GTEx DepMap Descartes 0.02 1.08
CLDN5 -0.0001022 14508 GTEx DepMap Descartes 0.03 4.56
BTNL9 -0.0001029 14534 GTEx DepMap Descartes 0.02 1.44
TM4SF18 -0.0001064 14659 GTEx DepMap Descartes 0.00 0.37
APLNR -0.0001068 14673 GTEx DepMap Descartes 0.01 0.43
NOTCH4 -0.0001130 14947 GTEx DepMap Descartes 0.02 0.77
CRHBP -0.0001139 14982 GTEx DepMap Descartes 0.00 0.53
CEACAM1 -0.0001151 15031 GTEx DepMap Descartes 0.12 11.53
SLCO2A1 -0.0001173 15105 GTEx DepMap Descartes 0.04 2.05
SHE -0.0001261 15410 GTEx DepMap Descartes 0.01 0.55
FLT4 -0.0001360 15750 GTEx DepMap Descartes 0.02 0.93
KDR -0.0001392 15865 GTEx DepMap Descartes 0.02 1.25
TIE1 -0.0001422 15964 GTEx DepMap Descartes 0.02 1.28


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15093.1
Median rank of genes in gene set: 16913
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCOLCE 0.0002206 1633 GTEx DepMap Descartes 0.67 162.35
LAMC3 0.0001271 2666 GTEx DepMap Descartes 0.09 4.33
CD248 0.0000650 3850 GTEx DepMap Descartes 0.03 4.93
GAS2 0.0000349 4716 GTEx DepMap Descartes 0.57 91.36
PDGFRA 0.0000044 6039 GTEx DepMap Descartes 0.06 3.82
CLDN11 -0.0000049 7746 GTEx DepMap Descartes 0.00 0.00
PAMR1 -0.0000145 9156 GTEx DepMap Descartes 0.16 15.27
SULT1E1 -0.0000349 11054 GTEx DepMap Descartes 0.00 0.03
ELN -0.0000516 12103 GTEx DepMap Descartes 0.28 30.54
SCARA5 -0.0000549 12270 GTEx DepMap Descartes 0.01 0.71
RSPO3 -0.0000699 13051 GTEx DepMap Descartes 0.01 NA
DKK2 -0.0000730 13221 GTEx DepMap Descartes 0.12 10.70
PCDH18 -0.0000795 13514 GTEx DepMap Descartes 0.02 1.23
LRRC17 -0.0000816 13600 GTEx DepMap Descartes 0.10 15.28
ACTA2 -0.0000850 13769 GTEx DepMap Descartes 0.24 70.08
SFRP2 -0.0000997 14408 GTEx DepMap Descartes 0.06 7.74
LOX -0.0001035 14557 GTEx DepMap Descartes 0.02 1.38
ISLR -0.0001237 15323 GTEx DepMap Descartes 0.01 1.68
FNDC1 -0.0001283 15491 GTEx DepMap Descartes 0.02 0.76
ABCC9 -0.0001498 16177 GTEx DepMap Descartes 0.04 1.75
MXRA5 -0.0001503 16196 GTEx DepMap Descartes 0.03 0.75
IGFBP3 -0.0001559 16365 GTEx DepMap Descartes 0.06 7.14
EDNRA -0.0001660 16636 GTEx DepMap Descartes 0.05 3.73
COL27A1 -0.0001672 16670 GTEx DepMap Descartes 0.07 2.68
ADAMTSL3 -0.0001785 16913 GTEx DepMap Descartes 0.25 10.48
GLI2 -0.0002036 17500 GTEx DepMap Descartes 0.16 7.81
CCDC102B -0.0002072 17580 GTEx DepMap Descartes 0.76 90.07
C7 -0.0002079 17592 GTEx DepMap Descartes 0.20 7.21
COL1A1 -0.0002120 17670 GTEx DepMap Descartes 0.70 32.22
CCDC80 -0.0002154 17734 GTEx DepMap Descartes 0.08 1.57


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13471.65
Median rank of genes in gene set: 18209
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
INSM1 0.0030086 46 GTEx DepMap Descartes 0.99 162.50
SLC35F3 0.0024424 68 GTEx DepMap Descartes 3.36 488.08
FAM155A 0.0017074 103 GTEx DepMap Descartes 42.63 1819.92
ARC 0.0016321 110 GTEx DepMap Descartes 0.67 88.61
SLC24A2 0.0013030 144 GTEx DepMap Descartes 0.68 23.62
CHGB 0.0005542 501 GTEx DepMap Descartes 6.19 941.70
SPOCK3 0.0004851 601 GTEx DepMap Descartes 1.93 228.83
CCSER1 0.0003135 1074 GTEx DepMap Descartes 14.87 NA
TIAM1 0.0001948 1869 GTEx DepMap Descartes 3.30 177.83
DGKK 0.0001805 1993 GTEx DepMap Descartes 0.28 14.06
PENK 0.0000083 5786 GTEx DepMap Descartes 0.12 35.55
PNMT -0.0000169 9417 GTEx DepMap Descartes 0.02 7.48
HTATSF1 -0.0000187 9601 GTEx DepMap Descartes 0.41 50.67
ROBO1 -0.0000191 9651 GTEx DepMap Descartes 12.43 594.10
CHGA -0.0000376 11228 GTEx DepMap Descartes 1.09 179.58
NTNG1 -0.0000536 12205 GTEx DepMap Descartes 2.47 166.19
TMEM130 -0.0000946 14183 GTEx DepMap Descartes 0.70 58.22
CNTN3 -0.0000971 14286 GTEx DepMap Descartes 0.21 13.52
CNTNAP5 -0.0001256 15393 GTEx DepMap Descartes 1.24 71.74
ST18 -0.0001526 16262 GTEx DepMap Descartes 0.09 5.03
SORCS3 -0.0001986 17399 GTEx DepMap Descartes 0.56 31.11
KSR2 -0.0002409 18209 GTEx DepMap Descartes 1.17 20.41
C1QL1 -0.0002540 18404 GTEx DepMap Descartes 0.10 22.50
SLC18A1 -0.0002856 18824 GTEx DepMap Descartes 0.27 30.41
LAMA3 -0.0003305 19254 GTEx DepMap Descartes 0.55 16.30
UNC80 -0.0003345 19297 GTEx DepMap Descartes 2.41 60.52
TBX20 -0.0003526 19450 GTEx DepMap Descartes 0.60 111.60
TENM1 -0.0003813 19652 GTEx DepMap Descartes 1.84 NA
PCSK1N -0.0003877 19694 GTEx DepMap Descartes 2.07 581.16
SCG2 -0.0004490 19998 GTEx DepMap Descartes 5.16 495.78


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.93e-01
Mean rank of genes in gene set: 12460.35
Median rank of genes in gene set: 13154.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ANK1 0.0004937 588 GTEx DepMap Descartes 1.41 62.52
EPB41 0.0002973 1141 GTEx DepMap Descartes 2.05 125.19
TSPAN5 0.0002484 1433 GTEx DepMap Descartes 2.73 250.55
HBZ 0.0000835 3422 GTEx DepMap Descartes 0.01 4.71
TFR2 0.0000267 5001 GTEx DepMap Descartes 0.32 37.45
SLC25A37 0.0000255 5053 GTEx DepMap Descartes 0.65 49.67
FECH 0.0000117 5618 GTEx DepMap Descartes 0.33 15.40
HBG1 0.0000011 6299 GTEx DepMap Descartes 0.00 0.00
HBG2 0.0000000 6773 GTEx DepMap Descartes 0.00 0.00
DENND4A -0.0000086 8359 GTEx DepMap Descartes 2.64 114.07
HEMGN -0.0000127 8930 GTEx DepMap Descartes 0.00 0.75
HBM -0.0000196 9704 GTEx DepMap Descartes 0.01 3.92
XPO7 -0.0000276 10487 GTEx DepMap Descartes 1.10 83.43
GYPE -0.0000303 10689 GTEx DepMap Descartes 0.05 9.48
HBB -0.0000392 11335 GTEx DepMap Descartes 0.19 106.03
EPB42 -0.0000397 11370 GTEx DepMap Descartes 0.00 0.34
RHCE -0.0000402 11398 GTEx DepMap Descartes 0.05 9.61
RHAG -0.0000599 12535 GTEx DepMap Descartes 0.00 0.60
AHSP -0.0000631 12719 GTEx DepMap Descartes 0.00 0.10
GYPA -0.0000635 12736 GTEx DepMap Descartes 0.01 1.22
ALAS2 -0.0000660 12862 GTEx DepMap Descartes 0.00 0.74
HBA1 -0.0000695 13034 GTEx DepMap Descartes 0.03 16.26
HBA2 -0.0000705 13092 GTEx DepMap Descartes 0.06 42.87
SPTA1 -0.0000730 13217 GTEx DepMap Descartes 0.00 0.06
TMCC2 -0.0000767 13388 GTEx DepMap Descartes 0.11 9.13
CAT -0.0000767 13389 GTEx DepMap Descartes 0.32 50.42
GYPB -0.0000779 13459 GTEx DepMap Descartes 0.02 10.58
SLC4A1 -0.0000780 13463 GTEx DepMap Descartes 0.01 0.54
CPOX -0.0000809 13575 GTEx DepMap Descartes 0.04 4.61
SELENBP1 -0.0000855 13794 GTEx DepMap Descartes 0.00 0.25


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 16211.02
Median rank of genes in gene set: 17701
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ATP8B4 0.0003947 789 GTEx DepMap Descartes 0.48 35.28
RGL1 0.0000967 3176 GTEx DepMap Descartes 0.98 74.19
ABCA1 0.0000895 3315 GTEx DepMap Descartes 0.78 30.64
SFMBT2 0.0000555 4089 GTEx DepMap Descartes 1.09 53.57
CTSD -0.0000072 8119 GTEx DepMap Descartes 0.00 0.01
ADAP2 -0.0000339 10982 GTEx DepMap Descartes 0.17 23.98
CYBB -0.0000778 13454 GTEx DepMap Descartes 0.00 0.11
VSIG4 -0.0000894 13956 GTEx DepMap Descartes 0.00 0.46
MS4A7 -0.0000941 14162 GTEx DepMap Descartes 0.00 0.52
CTSC -0.0001083 14731 GTEx DepMap Descartes 0.22 13.97
RNASE1 -0.0001243 15343 GTEx DepMap Descartes 0.02 6.94
ITPR2 -0.0001275 15459 GTEx DepMap Descartes 1.78 51.77
CPVL -0.0001530 16271 GTEx DepMap Descartes 0.20 30.43
CD163 -0.0001593 16456 GTEx DepMap Descartes 0.02 1.15
MS4A4E -0.0001673 16672 GTEx DepMap Descartes 0.02 2.02
MPEG1 -0.0001786 16916 GTEx DepMap Descartes 0.01 0.92
FGD2 -0.0001853 17064 GTEx DepMap Descartes 0.01 0.71
CSF1R -0.0001918 17226 GTEx DepMap Descartes 0.03 1.74
HCK -0.0001943 17288 GTEx DepMap Descartes 0.02 3.18
RBPJ -0.0002076 17586 GTEx DepMap Descartes 2.18 138.43
MS4A4A -0.0002113 17658 GTEx DepMap Descartes 0.02 3.24
IFNGR1 -0.0002125 17679 GTEx DepMap Descartes 0.26 36.81
HLA-DRB1 -0.0002130 17686 GTEx DepMap Descartes 0.02 3.47
SLC1A3 -0.0002133 17692 GTEx DepMap Descartes 0.09 5.31
FGL2 -0.0002137 17701 GTEx DepMap Descartes 0.02 1.34
C1QC -0.0002250 17946 GTEx DepMap Descartes 0.03 8.06
SLCO2B1 -0.0002342 18103 GTEx DepMap Descartes 0.08 3.58
CD14 -0.0002346 18106 GTEx DepMap Descartes 0.03 5.66
LGMN -0.0002370 18146 GTEx DepMap Descartes 0.19 30.57
MS4A6A -0.0002411 18213 GTEx DepMap Descartes 0.03 3.31


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15404
Median rank of genes in gene set: 17866
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TRPM3 0.0018116 95 GTEx DepMap Descartes 2.64 90.41
ERBB4 0.0016779 108 GTEx DepMap Descartes 7.56 254.75
EGFLAM 0.0007558 315 GTEx DepMap Descartes 1.30 98.37
DST 0.0002835 1223 GTEx DepMap Descartes 10.42 170.38
MARCKS 0.0002575 1375 GTEx DepMap Descartes 2.33 221.81
NLGN4X 0.0001390 2488 GTEx DepMap Descartes 3.80 237.71
GRIK3 0.0000116 5623 GTEx DepMap Descartes 0.35 15.99
ZNF536 0.0000086 5778 GTEx DepMap Descartes 1.99 142.02
IL1RAPL2 -0.0000638 12749 GTEx DepMap Descartes 0.62 70.24
COL25A1 -0.0000679 12949 GTEx DepMap Descartes 0.33 13.52
SOX10 -0.0000912 14037 GTEx DepMap Descartes 0.07 7.97
MPZ -0.0000916 14052 GTEx DepMap Descartes 0.03 4.15
ERBB3 -0.0000996 14402 GTEx DepMap Descartes 0.02 1.03
HMGA2 -0.0001228 15293 GTEx DepMap Descartes 0.02 0.93
OLFML2A -0.0001255 15390 GTEx DepMap Descartes 0.02 0.70
LAMB1 -0.0001324 15636 GTEx DepMap Descartes 1.36 86.12
PLP1 -0.0001482 16130 GTEx DepMap Descartes 0.01 0.74
ADAMTS5 -0.0001526 16263 GTEx DepMap Descartes 0.04 1.07
PTPRZ1 -0.0001541 16304 GTEx DepMap Descartes 0.02 0.67
PLCE1 -0.0001588 16441 GTEx DepMap Descartes 0.51 13.75
EDNRB -0.0001722 16768 GTEx DepMap Descartes 0.02 1.56
CDH19 -0.0001740 16810 GTEx DepMap Descartes 0.07 1.77
KCTD12 -0.0001989 17405 GTEx DepMap Descartes 0.10 4.95
LAMC1 -0.0002172 17784 GTEx DepMap Descartes 0.55 25.06
NRXN1 -0.0002211 17866 GTEx DepMap Descartes 11.77 407.32
PTN -0.0002287 18003 GTEx DepMap Descartes 0.45 89.53
ABCA8 -0.0002383 18167 GTEx DepMap Descartes 0.06 1.77
XKR4 -0.0002890 18860 GTEx DepMap Descartes 0.45 5.18
IL1RAPL1 -0.0002920 18902 GTEx DepMap Descartes 1.27 100.00
COL5A2 -0.0002964 18960 GTEx DepMap Descartes 0.24 11.30


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15928.06
Median rank of genes in gene set: 17754
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
STON2 0.0001409 2459 GTEx DepMap Descartes 0.48 45.17
ITGA2B 0.0000998 3114 GTEx DepMap Descartes 0.17 16.73
PSTPIP2 0.0000216 5207 GTEx DepMap Descartes 0.11 14.43
GP9 -0.0000004 7027 GTEx DepMap Descartes 0.00 0.02
SPN -0.0000070 8088 GTEx DepMap Descartes 0.00 0.00
PF4 -0.0000121 8853 GTEx DepMap Descartes 0.00 0.08
ITGB3 -0.0000140 9093 GTEx DepMap Descartes 0.00 0.01
PPBP -0.0000166 9374 GTEx DepMap Descartes 0.00 0.25
GP1BA -0.0000526 12150 GTEx DepMap Descartes 0.01 1.09
TPM4 -0.0000863 13829 GTEx DepMap Descartes 1.08 82.12
P2RX1 -0.0000909 14023 GTEx DepMap Descartes 0.01 1.20
TUBB1 -0.0000992 14381 GTEx DepMap Descartes 0.01 1.13
ZYX -0.0001037 14566 GTEx DepMap Descartes 0.14 22.80
MMRN1 -0.0001083 14733 GTEx DepMap Descartes 0.01 0.66
FLNA -0.0001246 15353 GTEx DepMap Descartes 0.39 17.63
ANGPT1 -0.0001291 15516 GTEx DepMap Descartes 0.18 12.90
TRPC6 -0.0001303 15553 GTEx DepMap Descartes 0.05 3.16
FERMT3 -0.0001317 15605 GTEx DepMap Descartes 0.06 8.81
TGFB1 -0.0001496 16169 GTEx DepMap Descartes 0.32 43.30
UBASH3B -0.0001554 16352 GTEx DepMap Descartes 0.42 21.84
BIN2 -0.0001693 16712 GTEx DepMap Descartes 0.04 4.61
PLEK -0.0001748 16828 GTEx DepMap Descartes 0.01 1.54
CD84 -0.0001902 17185 GTEx DepMap Descartes 0.01 0.60
STOM -0.0002084 17605 GTEx DepMap Descartes 0.18 19.07
SLC24A3 -0.0002162 17754 GTEx DepMap Descartes 0.61 45.11
MCTP1 -0.0002419 18224 GTEx DepMap Descartes 0.25 12.48
LIMS1 -0.0002546 18418 GTEx DepMap Descartes 1.35 106.27
ARHGAP6 -0.0002607 18512 GTEx DepMap Descartes 0.15 6.11
MYLK -0.0002619 18531 GTEx DepMap Descartes 0.23 6.67
ACTB -0.0002718 18639 GTEx DepMap Descartes 4.24 740.63


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 17433.02
Median rank of genes in gene set: 19291
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
FYN 0.0005414 521 GTEx DepMap Descartes 4.64 498.68
RAP1GAP2 0.0003400 972 GTEx DepMap Descartes 4.36 240.51
HLA-A 0.0000385 4595 GTEx DepMap Descartes 0.61 40.29
FOXP1 0.0000285 4938 GTEx DepMap Descartes 0.32 13.43
ABLIM1 -0.0000322 10830 GTEx DepMap Descartes 2.48 113.51
NKG7 -0.0000817 13603 GTEx DepMap Descartes 0.00 2.18
CELF2 -0.0001121 14902 GTEx DepMap Descartes 1.91 87.87
CCND3 -0.0001127 14935 GTEx DepMap Descartes 0.71 113.42
CCL5 -0.0001194 15173 GTEx DepMap Descartes 0.02 5.70
SORL1 -0.0001273 15452 GTEx DepMap Descartes 0.86 26.98
ARHGDIB -0.0002134 17695 GTEx DepMap Descartes 0.03 9.81
WIPF1 -0.0002367 18140 GTEx DepMap Descartes 0.90 71.59
LEF1 -0.0002394 18181 GTEx DepMap Descartes 0.36 37.16
MCTP2 -0.0002672 18589 GTEx DepMap Descartes 0.18 6.02
SKAP1 -0.0002722 18643 GTEx DepMap Descartes 0.23 46.73
PDE3B -0.0002777 18720 GTEx DepMap Descartes 2.17 123.10
RCSD1 -0.0002834 18791 GTEx DepMap Descartes 0.09 5.35
PRKCH -0.0002853 18819 GTEx DepMap Descartes 0.22 18.18
ITPKB -0.0002919 18900 GTEx DepMap Descartes 0.12 5.80
IKZF1 -0.0002938 18929 GTEx DepMap Descartes 0.14 8.58
PLEKHA2 -0.0002970 18964 GTEx DepMap Descartes 0.21 12.26
LCP1 -0.0002980 18975 GTEx DepMap Descartes 0.09 7.90
SAMD3 -0.0003022 19013 GTEx DepMap Descartes 0.21 14.64
EVL -0.0003342 19291 GTEx DepMap Descartes 3.15 297.46
ETS1 -0.0003372 19320 GTEx DepMap Descartes 0.17 10.56
NCALD -0.0003399 19350 GTEx DepMap Descartes 0.63 49.81
HLA-C -0.0003677 19563 GTEx DepMap Descartes 0.10 13.89
PTPRC -0.0003724 19597 GTEx DepMap Descartes 0.20 13.46
IFI16 -0.0003858 19682 GTEx DepMap Descartes 0.22 15.12
MSN -0.0004078 19818 GTEx DepMap Descartes 0.13 8.77


Embryonic Pausing Signatures Up
Embryonic pausing signature upregulated genes from Supplementary Table 6 of Rehman et al. Cell 2021. These genes are upregulated in paused ESCs and diapaused embryos.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.44e-01
Mean rank of genes in gene set: 8619.43
Median rank of genes in gene set: 5330
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DPP7 0.0007459 320 GTEx DepMap Descartes 0.73 179.76
PDCD4 0.0002408 1490 GTEx DepMap Descartes 0.91 97.27
RENBP 0.0001140 2863 GTEx DepMap Descartes 0.13 34.84
CCNG2 0.0001095 2934 GTEx DepMap Descartes 0.48 33.83
ALDH6A1 0.0000401 4544 GTEx DepMap Descartes 0.12 8.73
AUH 0.0000195 5279 GTEx DepMap Descartes 1.58 373.42
ACSS1 0.0000185 5329 GTEx DepMap Descartes 0.06 4.93
HEXA 0.0000184 5331 GTEx DepMap Descartes 0.04 2.33
LY6G6E 0.0000000 6866 GTEx DepMap Descartes 0.00 0.00
HEXB -0.0000793 13508 GTEx DepMap Descartes 0.25 45.24
SPRY1 -0.0001535 16285 GTEx DepMap Descartes 0.07 7.64
YPEL2 -0.0001862 17092 GTEx DepMap Descartes 0.64 38.11
CTSL -0.0002725 18647 GTEx DepMap Descartes 0.35 NA
APOE -0.0005136 20184 GTEx DepMap Descartes 0.33 82.60


Embryonic Pausing Signatures Down
Embryonic pausing signature downregulated genes from Supplementary Table 6 of Rehman et al. Cell 2021. These genes are downregulated in paused ESCs and diapaused embryos.
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.00e-04
Mean rank of genes in gene set: 8419.89
Median rank of genes in gene set: 6191
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RPL41 0.0035654 29 GTEx DepMap Descartes 7.83 5080.30
PPA1 0.0008626 258 GTEx DepMap Descartes 1.76 205.98
TMEM97 0.0005941 455 GTEx DepMap Descartes 0.40 66.97
EIF3B 0.0005384 525 GTEx DepMap Descartes 1.33 139.33
RPS27L 0.0004748 629 GTEx DepMap Descartes 0.78 58.41
SNRPE 0.0004564 663 GTEx DepMap Descartes 0.63 171.70
SNRPD2 0.0003500 934 GTEx DepMap Descartes 0.67 335.76
PHB 0.0003423 964 GTEx DepMap Descartes 0.62 120.78
SAC3D1 0.0003281 1010 GTEx DepMap Descartes 0.26 69.54
PA2G4 0.0003244 1024 GTEx DepMap Descartes 0.52 91.35
ANKRD37 0.0003182 1052 GTEx DepMap Descartes 0.09 25.66
PHGDH 0.0003097 1091 GTEx DepMap Descartes 0.23 29.53
TMEM258 0.0003015 1126 GTEx DepMap Descartes 0.66 NA
THOP1 0.0003004 1130 GTEx DepMap Descartes 0.36 30.82
HMGA1 0.0002938 1164 GTEx DepMap Descartes 0.49 95.41
HSPE1 0.0002726 1289 GTEx DepMap Descartes 0.69 396.46
ELOF1 0.0002544 1393 GTEx DepMap Descartes 0.16 28.63
RAN 0.0002147 1678 GTEx DepMap Descartes 1.21 192.46
SLC25A5 0.0002091 1726 GTEx DepMap Descartes 0.32 96.03
NABP2 0.0002001 1819 GTEx DepMap Descartes 0.16 NA
RCL1 0.0001985 1838 GTEx DepMap Descartes 0.92 170.25
DCTPP1 0.0001821 1980 GTEx DepMap Descartes 0.17 60.58
POLR2I 0.0001729 2088 GTEx DepMap Descartes 0.37 151.96
BYSL 0.0001552 2288 GTEx DepMap Descartes 0.08 19.97
EXOSC2 0.0001492 2358 GTEx DepMap Descartes 0.21 31.09
ANAPC15 0.0001451 2408 GTEx DepMap Descartes 0.10 NA
EXOSC4 0.0001416 2453 GTEx DepMap Descartes 0.11 38.26
SMS 0.0001348 2539 GTEx DepMap Descartes 1.35 300.55
DRG2 0.0001283 2651 GTEx DepMap Descartes 0.17 12.35
MDH2 0.0001199 2774 GTEx DepMap Descartes 0.53 92.34


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Megakaryocytes/platelets: Megakaryocytes/platelets (curated markers)
large multinucleated cells with numerous azurophilic granules and with mature blood platelets released from the cytoplasm:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.95e-02
Mean rank of genes in gene set: 4635
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
CMTM5 0.0001876 1938 GTEx DepMap Descartes 0.01 2.07
ITGA2B 0.0000998 3114 GTEx DepMap Descartes 0.17 16.73
PF4 -0.0000121 8853 GTEx DepMap Descartes 0.00 0.08


Erythroid: Early erythroid (model markers)
early erythroid cells which are committed to erythroid lineage cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 7.32e-02
Mean rank of genes in gene set: 7242.25
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FAM178B 0.0001105 2915 GTEx DepMap Descartes 0.06 8.18
CD207 0.0000769 3554 GTEx DepMap Descartes 0.01 1.22
PRSS57 0.0000613 3939 GTEx DepMap Descartes 0.01 3.12
PCLAF 0.0000315 4823 GTEx DepMap Descartes 0.01 NA
IL17A -0.0000033 7500 GTEx DepMap Descartes 0.00 0.00
OR2A25 -0.0000094 8470 GTEx DepMap Descartes 0.00 0.01
PRG2 -0.0000117 8801 GTEx DepMap Descartes 0.00 0.00
APOC1 -0.0002243 17936 GTEx DepMap Descartes 0.06 32.44


Erythroid: Mid erythroid (curated markers)
middle erythroid cells in fetal liver:
Wilcoxon ranksum test P-value for gene set overrepresentation: 8.53e-02
Mean rank of genes in gene set: 5591.67
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
KCNH2 0.0003489 941 GTEx DepMap Descartes 0.49 40.73
PRDX2 0.0001007 3098 GTEx DepMap Descartes 0.21 46.11
GYPA -0.0000635 12736 GTEx DepMap Descartes 0.01 1.22