Program: 30. Unclear.

Program: 30. Unclear.


Program description and justification of annotation generated by GPT5: Ribosome/Translation and ER co-translational targeting (MYC/MYCN-associated), ubiquitous with strongest activation in adrenergic neuroblastoma cells.

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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 RPL18A 0.0166859 ribosomal protein L18a GTEx DepMap Descartes 6.92 3068.95
2 RPL13 0.0161454 ribosomal protein L13 GTEx DepMap Descartes 18.00 2459.51
3 RPS2 0.0160635 ribosomal protein S2 GTEx DepMap Descartes 10.51 4193.09
4 RPL10 0.0153615 ribosomal protein L10 GTEx DepMap Descartes 10.55 2725.06
5 RPL32 0.0149610 ribosomal protein L32 GTEx DepMap Descartes 8.75 2596.49
6 RPS18 0.0149211 ribosomal protein S18 GTEx DepMap Descartes 15.68 8546.52
7 RPS23 0.0145858 ribosomal protein S23 GTEx DepMap Descartes 9.47 1802.83
8 RPS15 0.0145565 ribosomal protein S15 GTEx DepMap Descartes 10.13 4004.58
9 RPS19 0.0144405 ribosomal protein S19 GTEx DepMap Descartes 8.95 2557.93
10 RPS27 0.0144188 ribosomal protein S27 GTEx DepMap Descartes 6.70 6659.67
11 RPS3A 0.0143640 ribosomal protein S3A GTEx DepMap Descartes 8.40 3517.66
12 RPS24 0.0141077 ribosomal protein S24 GTEx DepMap Descartes 13.06 2503.22
13 RPS3 0.0140852 ribosomal protein S3 GTEx DepMap Descartes 8.25 2432.67
14 RPL36 0.0139532 ribosomal protein L36 GTEx DepMap Descartes 8.16 5540.31
15 RPS14 0.0139471 ribosomal protein S14 GTEx DepMap Descartes 8.27 1598.89
16 RPS27A 0.0137299 ribosomal protein S27a GTEx DepMap Descartes 8.61 4415.76
17 RPL35A 0.0137022 ribosomal protein L35a GTEx DepMap Descartes 5.85 2921.88
18 RPLP1 0.0136827 ribosomal protein lateral stalk subunit P1 GTEx DepMap Descartes 11.89 3629.98
19 RPS4X 0.0135370 ribosomal protein S4 X-linked GTEx DepMap Descartes 6.56 2122.64
20 RPL18 0.0135158 ribosomal protein L18 GTEx DepMap Descartes 6.87 1064.24
21 RPL29 0.0135010 ribosomal protein L29 GTEx DepMap Descartes 6.58 4402.35
22 RPL3 0.0133817 ribosomal protein L3 GTEx DepMap Descartes 9.42 2618.05
23 RPL7A 0.0133248 ribosomal protein L7a GTEx DepMap Descartes 6.93 3447.70
24 RPS7 0.0131780 ribosomal protein S7 GTEx DepMap Descartes 8.82 985.96
25 RPS28 0.0130954 ribosomal protein S28 GTEx DepMap Descartes 5.06 1950.01
26 RPL24 0.0130127 ribosomal protein L24 GTEx DepMap Descartes 6.15 2052.29
27 RPL30 0.0129978 ribosomal protein L30 GTEx DepMap Descartes 7.73 4239.91
28 RPS12 0.0128531 ribosomal protein S12 GTEx DepMap Descartes 5.93 5674.27
29 RPL34 0.0127722 ribosomal protein L34 GTEx DepMap Descartes 7.68 1826.40
30 RPLP0 0.0126641 ribosomal protein lateral stalk subunit P0 GTEx DepMap Descartes 6.42 1504.56
31 RPL37A 0.0126633 ribosomal protein L37a GTEx DepMap Descartes 9.86 1993.94
32 RPL13A 0.0125852 ribosomal protein L13a GTEx DepMap Descartes 7.08 1915.49
33 RPL19 0.0125551 ribosomal protein L19 GTEx DepMap Descartes 9.87 4886.10
34 RPSA 0.0125436 ribosomal protein SA GTEx DepMap Descartes 6.36 1789.86
35 RPS15A 0.0125356 ribosomal protein S15a GTEx DepMap Descartes 4.12 692.64
36 RPS6 0.0125108 ribosomal protein S6 GTEx DepMap Descartes 5.97 2720.72
37 RPL15 0.0124386 ribosomal protein L15 GTEx DepMap Descartes 7.02 1290.05
38 RPS13 0.0124109 ribosomal protein S13 GTEx DepMap Descartes 5.24 4271.61
39 RACK1 0.0123656 receptor for activated C kinase 1 GTEx DepMap Descartes 4.71 NA
40 RPL41 0.0122859 ribosomal protein L41 GTEx DepMap Descartes 6.27 5388.55
41 RPL8 0.0122837 ribosomal protein L8 GTEx DepMap Descartes 8.60 4927.99
42 RPL12 0.0122804 ribosomal protein L12 GTEx DepMap Descartes 4.56 1281.90
43 RPL6 0.0122444 ribosomal protein L6 GTEx DepMap Descartes 6.91 2127.11
44 RPS5 0.0122322 ribosomal protein S5 GTEx DepMap Descartes 4.52 1526.89
45 RPL14 0.0122169 ribosomal protein L14 GTEx DepMap Descartes 5.92 489.17
46 RPL37 0.0122168 ribosomal protein L37 GTEx DepMap Descartes 6.59 545.65
47 RPS16 0.0121238 ribosomal protein S16 GTEx DepMap Descartes 4.67 1207.33
48 EEF1A1 0.0121184 eukaryotic translation elongation factor 1 alpha 1 GTEx DepMap Descartes 7.90 1059.34
49 RPL11 0.0120315 ribosomal protein L11 GTEx DepMap Descartes 8.85 3384.12
50 RPL5 0.0116748 ribosomal protein L5 GTEx DepMap Descartes 5.88 2956.87


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UMAP plots showing activity of gene expression program identified in GEP 30. Unclear:

Interactive UMAP Plot
Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 30. Unclear:
Interactive Boxplot
Interactive Boxplot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
RUBENSTEIN_SKELETAL_MUSCLE_T_CELLS 6.16e-107 Inf 2100.51 4.13e-104 4.13e-104
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 181
RUBENSTEIN_SKELETAL_MUSCLE_SATELLITE_CELLS 5.95e-94 Inf 1050.26 7.99e-92 4.00e-91
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 310
BUSSLINGER_GASTRIC_PPP1R1B_POSITIVE_CELLS 1.12e-95 1976.54 791.12 2.50e-93 7.50e-93
44RPL18A, RPL13, RPS2, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS28, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 121
RUBENSTEIN_SKELETAL_MUSCLE_B_CELLS 1.34e-96 2341.84 760.13 4.50e-94 9.01e-94
47RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL30, RPS12, RPL34, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, EEF1A1, RPL11, RPL5
 177
BUSSLINGER_DUODENAL_TRANSIT_AMPLIFYING_CELLS 1.83e-94 2087.76 690.91 3.07e-92 1.23e-91
47RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 194
TRAVAGLINI_LUNG_CD4_NAIVE_T_CELL 1.18e-93 1735.10 671.22 1.32e-91 7.90e-91
44RPL18A, RPL13, RPS2, RPL10, RPL32, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPL18, RPL29, RPL3, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 132
BUSSLINGER_DUODENAL_DIFFERENTIATING_STEM_CELLS 9.99e-91 3775.62 668.68 9.58e-89 6.71e-88
49RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 305
BUSSLINGER_GASTRIC_LYZ_POSITIVE_CELLS 4.16e-88 1360.97 600.92 3.49e-86 2.79e-85
41RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS27, RPS3A, RPS3, RPL36, RPS14, RPL35A, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL19, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL12, RPL6, RPS5, RPL14, RPL37, EEF1A1, RPL11, RPL5
 111
TRAVAGLINI_LUNG_BRONCHIAL_VESSEL_1_CELL 4.81e-88 1329.18 478.71 3.58e-86 3.23e-85
46RPL18A, RPL13, RPS2, RPL10, RPL32, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 224
BUSSLINGER_DUODENAL_STEM_CELLS 6.08e-81 896.42 320.24 4.08e-79 4.08e-78
46RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPL37A, RPL13A, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 311
TRAVAGLINI_LUNG_CLUB_CELL 5.44e-70 601.41 304.13 2.15e-68 3.65e-67
35RPL18A, RPL13, RPL10, RPL32, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPL35A, RPL18, RPL29, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPL37A, RPL13A, RPL19, RPS15A, RPS6, RPL15, RPS13, RPL12, RPS5, RPL37, RPS16, RPL11, RPL5
 114
FAN_OVARY_CL0_XBP1_SELK_HIGH_STROMAL_CELL 3.94e-74 621.03 302.39 2.03e-72 2.64e-71
38RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL3, RPL24, RPL30, RPS12, RPL34, RPL13A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL11, RPL5
 143
LAKE_ADULT_KIDNEY_C7_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S3 1.06e-69 531.01 271.26 3.96e-68 7.12e-67
36RPL13, RPL32, RPS18, RPS23, RPS15, RPS19, RPS3A, RPS24, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPS12, RPL34, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPS13, RPL8, RPL12, RPL6, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 135
LAKE_ADULT_KIDNEY_C19_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_A_MEDULLA 4.09e-77 657.54 258.22 2.49e-75 2.74e-74
45RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPS16, EEF1A1, RPL11, RPL5
 326
LAKE_ADULT_KIDNEY_C8_DECENDING_THIN_LIMB 7.17e-75 536.14 236.51 4.01e-73 4.81e-72
43RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS14, RPS27A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPS16, EEF1A1, RPL11, RPL5
 278
LAKE_ADULT_KIDNEY_C12_THICK_ASCENDING_LIMB 6.45e-74 550.07 217.37 3.09e-72 4.33e-71
45RPL13, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 381
LAKE_ADULT_KIDNEY_C18_COLLECTING_DUCT_PRINCIPAL_CELLS_MEDULLA 5.85e-72 454.36 199.45 2.62e-70 3.93e-69
43RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS14, RPS27A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPS16, EEF1A1, RPL11, RPL5
 322
LAKE_ADULT_KIDNEY_C9_THIN_ASCENDING_LIMB 2.75e-70 412.25 194.25 1.15e-68 1.85e-67
41RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS3A, RPS24, RPS3, RPS14, RPS27A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPL15, RPS13, RACK1, RPL8, RPL12, RPL6, RPS5, RPL14, RPS16, EEF1A1, RPL11, RPL5
 268
TRAVAGLINI_LUNG_PROXIMAL_BASAL_CELL 4.99e-69 548.55 176.67 1.76e-67 3.35e-66
47RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL30, RPS12, RPL34, RPLP0, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 629
LAKE_ADULT_KIDNEY_C10_THIN_ASCENDING_LIMB 1.32e-67 342.85 159.69 4.42e-66 8.84e-65
42RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS14, RPS27A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPS16, EEF1A1, RPL11, RPL5
 353

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_MYC_TARGETS_V1 3.99e-11 27.00 11.87 1.99e-09 1.99e-09
10RPS2, RPS3, RPL18, RPL34, RPLP0, RPS6, RACK1, RPL6, RPS5, RPL14
 200
HALLMARK_P53_PATHWAY 1.36e-03 9.11 2.36 3.39e-02 6.78e-02
4RPL36, RPL18, RPS12, RACK1
 200
HALLMARK_ALLOGRAFT_REJECTION 8.36e-02 4.32 0.51 1.00e+00 1.00e+00
2RPS19, RPS3A
 200
HALLMARK_UNFOLDED_PROTEIN_RESPONSE 2.40e-01 3.74 0.09 1.00e+00 1.00e+00
1RPS14
 113
HALLMARK_TNFA_SIGNALING_VIA_NFKB 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_HYPOXIA 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 74
HALLMARK_MITOTIC_SPINDLE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 199
HALLMARK_WNT_BETA_CATENIN_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 42
HALLMARK_TGF_BETA_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 54
HALLMARK_IL6_JAK_STAT3_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 87
HALLMARK_DNA_REPAIR 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 150
HALLMARK_G2M_CHECKPOINT 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_APOPTOSIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 161
HALLMARK_NOTCH_SIGNALING 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 32
HALLMARK_ADIPOGENESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200
HALLMARK_ANDROGEN_RESPONSE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 100
HALLMARK_MYOGENESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_RIBOSOME 1.70e-114 9969.60 2409.41 3.17e-112 3.17e-112
47RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 88
KEGG_MTOR_SIGNALING_PATHWAY 1.19e-01 8.21 0.20 1.00e+00 1.00e+00
1RPS6
 52
KEGG_INSULIN_SIGNALING_PATHWAY 2.83e-01 3.08 0.08 1.00e+00 1.00e+00
1RPS6
 137
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_GLYCEROLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 49
KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 25
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 77
KEGG_ETHER_LIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 33
KEGG_ARACHIDONIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 58
KEGG_LINOLEIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 29
KEGG_ALPHA_LINOLENIC_ACID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 19
KEGG_SPHINGOLIPID_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 39
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 26
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 14
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15
KEGG_RIBOFLAVIN_METABOLISM 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16

Dowload full table

CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr3p22 6.01e-02 5.25 0.61 1.00e+00 1.00e+00
2RPSA, RPL14
 165
chr19q13 1.92e-01 1.97 0.61 1.00e+00 1.00e+00
5RPS19, RPL18, RPL13A, RPS5, RPS16
 1165
chr19p13 1.06e-01 2.32 0.61 1.00e+00 1.00e+00
4RPL18A, RPS15, RPL36, RPS28
 773
chr12q24 2.38e-01 2.21 0.26 1.00e+00 1.00e+00
2RPLP0, RPL6
 390
chr3q12 1.06e-01 9.31 0.23 1.00e+00 1.00e+00
1RPL24
 46
chr6q13 1.27e-01 7.62 0.19 1.00e+00 1.00e+00
1EEF1A1
 56
chr15q23 1.46e-01 6.55 0.16 1.00e+00 1.00e+00
1RPLP1
 65
chr4q25 1.90e-01 4.87 0.12 1.00e+00 1.00e+00
1RPL34
 87
chr3p24 2.14e-01 4.28 0.11 1.00e+00 1.00e+00
1RPL15
 99
chr6q23 2.27e-01 3.99 0.10 1.00e+00 1.00e+00
1RPS12
 106
chr5q33 2.32e-01 3.88 0.10 1.00e+00 1.00e+00
1RPS14
 109
chr2p16 2.42e-01 3.71 0.09 1.00e+00 1.00e+00
1RPS27A
 114
chr2p25 2.47e-01 3.61 0.09 1.00e+00 1.00e+00
1RPS7
 117
chr3q29 2.56e-01 3.46 0.09 1.00e+00 1.00e+00
1RPL35A
 122
chr2q35 2.63e-01 3.35 0.08 1.00e+00 1.00e+00
1RPL37A
 126
chr5p13 2.67e-01 3.30 0.08 1.00e+00 1.00e+00
1RPL37
 128
chr1p22 2.69e-01 3.27 0.08 1.00e+00 1.00e+00
1RPL5
 129
chr16q24 2.70e-01 3.25 0.08 1.00e+00 1.00e+00
1RPL13
 130
chr5q14 2.70e-01 3.25 0.08 1.00e+00 1.00e+00
1RPS23
 130
chr9q33 2.72e-01 3.22 0.08 1.00e+00 1.00e+00
1RPL12
 131

Dowload full table

Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
ZZZ3_TARGET_GENES 1.96e-20 74.52 36.06 5.55e-18 2.22e-17
14RPS2, RPS18, RPS23, RPS3A, RPS3, RPS14, RPL35A, RPS7, RPL24, RPL37A, RPL41, RPL8, RPL6, RPL37
 121
GTF2A2_TARGET_GENES 6.33e-29 44.88 24.57 3.59e-26 7.17e-26
26RPL13, RPS2, RPL10, RPS18, RPS27, RPS3A, RPS24, RPS3, RPL36, RPLP1, RPL18, RPL29, RPL3, RPS7, RPL24, RPS12, RPLP0, RPL37A, RPSA, RPS6, RPL15, RPL8, RPL12, RPS5, EEF1A1, RPL11
 522
SNRNP70_TARGET_GENES 3.45e-32 40.88 22.03 3.90e-29 3.90e-29
33RPL13, RPS2, RPL10, RPL32, RPS23, RPS15, RPS19, RPS24, RPS3, RPS14, RPL35A, RPL18, RPL3, RPL7A, RPL30, RPLP0, RPL13A, RPL19, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL37, RPS16, EEF1A1, RPL11, RPL5
 1009
TAF9B_TARGET_GENES 6.85e-25 35.04 19.13 2.59e-22 7.76e-22
24RPL10, RPS15, RPS27, RPS24, RPS3, RPS14, RPL35A, RPS4X, RPL29, RPL3, RPL7A, RPS28, RPL34, RPL37A, RPL13A, RPS6, RACK1, RPL41, RPL12, RPL6, RPL14, EEF1A1, RPL11, RPL5
 565
HJURP_TARGET_GENES 6.01e-07 73.99 18.01 2.30e-05 6.80e-04
4RPL3, RPS15A, RACK1, EEF1A1
 28
PER1_TARGET_GENES 1.19e-06 61.45 15.09 4.21e-05 1.35e-03
4RPL3, RPL34, RPL12, EEF1A1
 33
FOXR2_TARGET_GENES 2.55e-13 29.19 13.70 2.63e-11 2.89e-10
12RPL32, RPS18, RPS27, RPS14, RPL34, RPS6, RACK1, RPL8, RPL6, RPS5, RPS16, EEF1A1
 234
ZNF318_TARGET_GENES 3.13e-17 24.22 12.70 5.06e-15 3.55e-14
18RPL13, RPL32, RPS18, RPS3A, RPS24, RPS3, RPS14, RPL29, RPL7A, RPS7, RPL34, RPL37A, RPS15A, RACK1, RPL41, RPL37, EEF1A1, RPL5
 495
FOXE1_TARGET_GENES 1.44e-19 22.87 12.40 3.26e-17 1.63e-16
22RPL13, RPL32, RPS15, RPS27, RPS24, RPS3, RPS14, RPS4X, RPL18, RPL29, RPL3, RPS28, RPS12, RPLP0, RPS15A, RPS6, RPL15, RPL41, RPL12, RPL6, RPL11, RPL5
 728
PSMB5_TARGET_GENES 2.52e-13 24.55 11.84 2.63e-11 2.85e-10
13RPS2, RPL10, RPL32, RPS27, RPLP1, RPL3, RPS28, RPS12, RPLP0, RPL13A, RPSA, RPL12, EEF1A1
 307
ZFHX3_TARGET_GENES 4.04e-19 15.53 8.54 7.63e-17 4.58e-16
29RPL10, RPS18, RPS23, RPS27, RPS24, RPS3, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPL30, RPS12, RPL34, RPLP0, RPL13A, RPL19, RPS15A, RPS6, RPS13, RACK1, RPL8, RPS5, RPL37, EEF1A1, RPL5
 1857
GTF2E2_TARGET_GENES 1.67e-10 16.26 7.67 1.35e-08 1.90e-07
12RPL10, RPL36, RPLP1, RPS28, RPS12, RPLP0, RPS6, RACK1, RPL41, RPL12, RPL37, EEF1A1
 411
RUVBL1_TARGET_GENES 2.39e-07 19.32 7.23 1.12e-05 2.70e-04
7RPS14, RPL18, RPL24, RPS12, RPL41, EEF1A1, RPL11
 180
KAT2A_TARGET_GENES 2.27e-14 13.10 7.08 2.85e-12 2.57e-11
21RPS2, RPS15, RPS3, RPL36, RPL35A, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS12, RPL34, RPL13A, RPS13, RACK1, RPL41, RPL8, RPL6, RPS16, RPL5
 1157
ADA2_TARGET_GENES 3.39e-12 12.77 6.64 3.20e-10 3.84e-09
17RPL13, RPS2, RPL32, RPS18, RPS3A, RPS24, RPS3, RPS14, RPL18, RPL29, RPL3, RPS7, RPL8, RPL37, EEF1A1, RPL11, RPL5
 846
NFRKB_TARGET_GENES 1.06e-14 11.31 6.22 1.49e-12 1.20e-11
25RPL32, RPS18, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPL35A, RPL29, RPL3, RPS7, RPL30, RPL34, RPL13A, RPS15A, RPS6, RPS13, RACK1, RPL41, RPL8, RPL6, RPL14, RPL37, RPL11
 1843
KAT5_TARGET_GENES 1.19e-10 10.81 5.55 1.04e-08 1.35e-07
16RPL18A, RPL13, RPL10, RPL32, RPS23, RPS15, RPS24, RPL36, RPS14, RPL34, RPL37A, RPL19, RPSA, RPS6, EEF1A1, RPL5
 910
CHAF1B_TARGET_GENES 3.41e-10 10.02 5.14 2.42e-08 3.86e-07
16RPS2, RPS27, RPL36, RPLP1, RPL18, RPL3, RPS7, RPL24, RPL30, RPS12, RPL13A, RPS15A, RPL12, RPS16, EEF1A1, RPL5
 981
SETD7_TARGET_GENES 3.93e-10 9.92 5.09 2.62e-08 4.45e-07
16RPL13, RPS2, RPL10, RPS15, RPS19, RPS3A, RPS14, RPL3, RPL13A, RPS15A, RPS6, RPL15, RACK1, RPL14, EEF1A1, RPL5
 991
TET1_TARGET_GENES 5.70e-09 9.50 4.71 3.40e-07 6.45e-06
14RPL18A, RPS19, RPS3A, RPS24, RPL35A, RPL29, RPL3, RPS7, RPS28, RPL24, RPS15A, RPS6, RPL12, RPL5
 855

Dowload full table

GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 7.88e-113 7827.50 2100.51 5.89e-109 5.89e-109
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 107
GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 9.43e-110 6515.45 1794.17 3.53e-106 7.06e-106
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 120
GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 1.56e-109 6432.20 1777.46 3.89e-106 1.17e-105
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 121
GOBP_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 3.25e-104 4731.23 1204.71 6.08e-101 2.43e-100
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 149
GOBP_VIRAL_GENE_EXPRESSION 2.48e-97 3227.55 873.99 3.09e-94 1.86e-93
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 198
GOBP_TRANSLATIONAL_INITIATION 6.16e-98 3335.96 859.01 9.22e-95 4.61e-94
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 193
GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS 3.57e-96 3030.49 810.98 3.34e-93 2.67e-92
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 208
GOBP_PROTEIN_TARGETING_TO_MEMBRANE 3.57e-96 3030.49 810.98 3.34e-93 2.67e-92
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 208
GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE 1.53e-87 3223.65 561.10 1.27e-84 1.15e-83
49RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 351
GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS 2.02e-74 Inf 384.86 1.26e-71 1.51e-70
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 740
GOBP_RNA_CATABOLIC_PROCESS 1.03e-80 1340.25 349.09 7.74e-78 7.74e-77
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 414
GOBP_PROTEIN_TARGETING 1.72e-79 1258.39 331.68 1.17e-76 1.28e-75
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 438
GOBP_AMIDE_BIOSYNTHETIC_PROCESS 9.37e-71 Inf 324.73 4.38e-68 7.01e-67
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 877
GOBP_PEPTIDE_METABOLIC_PROCESS 3.96e-70 Inf 314.82 1.74e-67 2.97e-66
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 903
GOBP_PROTEIN_LOCALIZATION_TO_MEMBRANE 9.40e-74 1629.24 283.36 5.41e-71 7.03e-70
49RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 658
GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE 1.23e-73 931.24 241.99 6.55e-71 9.17e-70
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 576
GOBP_CELLULAR_AMIDE_METABOLIC_PROCESS 2.30e-64 Inf 234.91 8.59e-62 1.72e-60
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 1185
GOBP_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS 1.62e-71 835.23 219.96 8.09e-69 1.21e-67
48RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 637
GOBP_MACROMOLECULE_CATABOLIC_PROCESS 1.83e-60 Inf 195.37 5.96e-58 1.37e-56
50RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, EEF1A1, RPL11, RPL5
 1429
GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_SYMBIOTIC_INTERACTION 5.59e-65 1053.13 181.28 2.32e-62 4.18e-61
49RPL18A, RPL13, RPS2, RPL10, RPL32, RPS18, RPS23, RPS15, RPS19, RPS27, RPS3A, RPS24, RPS3, RPL36, RPS14, RPS27A, RPL35A, RPLP1, RPS4X, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS28, RPL24, RPL30, RPS12, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 997

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 2.28e-65 354.49 181.64 1.11e-61 1.11e-61
37RPL18A, RPL13, RPS2, RPL10, RPS18, RPS23, RPS19, RPS27, RPS3A, RPS3, RPL36, RPS14, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPL24, RPL30, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RACK1, RPL41, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 200
GSE2405_0H_VS_9H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN 7.56e-63 320.65 165.71 1.84e-59 3.68e-59
36RPL18A, RPL13, RPS2, RPL10, RPS18, RPS23, RPS19, RPS27, RPS3A, RPS3, RPL36, RPS14, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPL24, RPL30, RPL34, RPLP0, RPL37A, RPL13A, RPL19, RPSA, RPS15A, RPS6, RACK1, RPL12, RPL6, RPS5, RPL14, RPL37, RPS16, RPL11, RPL5
 200
GSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN 3.54e-44 151.48 81.77 5.75e-41 1.73e-40
28RPL13, RPL10, RPS18, RPS23, RPS3A, RPS3, RPS14, RPLP1, RPS4X, RPL18, RPL3, RPS7, RPL24, RPL34, RPLP0, RPL37A, RPL19, RPSA, RPS15A, RPS6, RACK1, RPL41, RPL12, RPL6, RPS5, RPS16, RPL11, RPL5
 200
GSE41978_KLRG1_HIGH_VS_LOW_EFFECTOR_CD8_TCELL_DN 5.13e-42 138.95 75.21 6.25e-39 2.50e-38
27RPS2, RPL10, RPS18, RPS23, RPS19, RPS3A, RPS3, RPS14, RPLP1, RPS4X, RPL18, RPL3, RPL7A, RPS7, RPL24, RPL34, RPLP0, RPL19, RPS15A, RPS6, RPL12, RPL6, RPS5, RPL37, RPS16, RPL11, RPL5
 200
GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP 5.95e-40 128.59 69.37 5.80e-37 2.90e-36
26RPL10, RPS18, RPS15, RPS19, RPS27, RPS24, RPS14, RPS27A, RPL35A, RPLP1, RPL7A, RPS7, RPL30, RPL34, RPL37A, RPS6, RPL15, RPS13, RACK1, RPL41, RPL8, RPL6, RPS5, RPL37, RPS16, RPL11
 199
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_2H_DN 9.38e-36 107.26 57.88 7.62e-33 4.57e-32
24RPL13, RPL10, RPL32, RPS18, RPS15, RPS24, RPL36, RPL35A, RPL29, RPL7A, RPS7, RPS28, RPL24, RPL30, RPL19, RPS15A, RPS13, RACK1, RPL8, RPL6, RPL14, RPL37, RPS16, RPL11
 200
GSE14000_TRANSLATED_RNA_VS_MRNA_DC_DN 4.59e-32 93.69 49.99 3.20e-29 2.24e-28
22RPL10, RPL32, RPS18, RPS3, RPL36, RPS14, RPLP1, RPL18, RPL30, RPS12, RPLP0, RPL13A, RPL19, RPSA, RPS15A, RPS6, RPS13, RACK1, RPL8, RPL12, RPS5, RPL11
 194
GSE42088_UNINF_VS_LEISHMANIA_INF_DC_4H_DN 8.21e-32 91.05 48.63 5.00e-29 4.00e-28
22RPL13, RPL10, RPL32, RPS18, RPS19, RPS24, RPS14, RPL35A, RPLP1, RPS4X, RPL18, RPS7, RPL30, RPL34, RPL13A, RPS15A, RPS13, RACK1, RPL8, RPL37, RPS16, RPL11
 199
GSE22886_NAIVE_TCELL_VS_DC_UP 7.20e-30 83.45 44.36 3.90e-27 3.51e-26
21RPS18, RPS23, RPS15, RPS27, RPS3, RPL36, RPS14, RPL35A, RPL29, RPL3, RPL7A, RPS7, RPL30, RPL34, RPL13A, RPL19, RPS15A, RPL6, RPL14, RPL11, RPL5
 199
GSE3720_UNSTIM_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_UP 3.47e-27 80.58 42.09 1.69e-24 1.69e-23
19RPS2, RPL32, RPS27, RPS3, RPL36, RPLP1, RPL18, RPL29, RPL3, RPL24, RPL30, RPS12, RPLP0, RPL37A, RPL19, RPSA, RPL12, RPL37, EEF1A1
 175
GSE3720_UNSTIM_VS_LPS_STIM_VD2_GAMMADELTA_TCELL_UP 1.13e-25 77.43 39.97 5.01e-23 5.51e-22
18RPS2, RPL32, RPS19, RPS3, RPL36, RPL18, RPL29, RPL3, RPL30, RPS12, RPLP0, RPL37A, RPSA, RPL8, RPL12, RPL14, RPL37, RPL5
 167
GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_UP 2.63e-24 64.12 33.24 1.07e-21 1.28e-20
18RPL13, RPL10, RPL32, RPS18, RPS23, RPS3A, RPS3, RPS14, RPLP1, RPL18, RPL7A, RPS12, RPL19, RPL15, RACK1, RPL8, RPS5, RPL5
 198
GSE3565_DUSP1_VS_WT_SPLENOCYTES_POST_LPS_INJECTION_UP 2.71e-20 59.08 29.28 8.79e-18 1.32e-16
15RPL13, RPS2, RPL32, RPS15, RPL36, RPL35A, RPLP1, RPL18, RPL29, RPL24, RPLP0, RPL19, RPS15A, RPL8, RPS5
 164
GSE42724_NAIVE_VS_B1_BCELL_DN 1.00e-20 52.75 26.70 3.75e-18 4.88e-17
16RPL13, RPS2, RPS3, RPL29, RPL3, RPL7A, RPS7, RPL34, RPL13A, RPSA, RPS6, RPL15, RACK1, RPL8, RPS5, RPL5
 199
GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_UP 1.09e-20 52.46 26.56 3.78e-18 5.29e-17
16RPL13, RPS3A, RPS3, RPS27A, RPL35A, RPL18, RPL29, RPL3, RPL7A, RPS7, RPS15A, RPL15, RPL6, RPS5, RPL37, RPL5
 200
GSE26156_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_UP 2.38e-17 43.13 21.13 7.23e-15 1.16e-13
14RPL13, RPL10, RPL32, RPS23, RPS27A, RPL29, RPS28, RPL30, RPS12, RPL34, RPS15A, RPS13, RPL37, RPL11
 199
GSE24574_BCL6_HIGH_TFH_VS_TFH_CD4_TCELL_DN 2.55e-17 42.89 21.02 7.30e-15 1.24e-13
14RPL13, RPL10, RPL32, RPS23, RPS27A, RPL29, RPS28, RPL30, RPS12, RPL34, RPS15A, RPS13, RPL37, RPS16
 200
GSE10239_NAIVE_VS_DAY4.5_EFF_CD8_TCELL_UP 9.95e-16 38.77 18.60 2.69e-13 4.85e-12
13RPL13, RPL32, RPS18, RPS3, RPL36, RPS14, RPLP1, RPS7, RPLP0, RPL37A, RPL19, RPS15A, RPL11
 199
GSE5099_CLASSICAL_M1_VS_ALTERNATIVE_M2_MACROPHAGE_UP 2.77e-14 35.61 16.66 7.11e-12 1.35e-10
12RPL13, RPL32, RPS18, RPS19, RPLP1, RPL29, RPL7A, RPL30, RPL13A, RPS15A, RPL12, RPL6
 194
GSE26488_WT_VS_VP16_TRANSGENIC_HDAC7_KO_DOUBLE_POSITIVE_THYMOCYTE_DN 2.13e-13 36.63 16.61 4.95e-11 1.04e-09
11RPL13, RPL32, RPS14, RPS4X, RPL24, RPL37A, RPL19, RPS13, RPL12, RPS5, RPL37
 169

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol Gene Loading Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
RPS27A 16 No ssDNA/RNA binding Not a DNA binding protein No motif None None
RPL7A 23 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
RPL7 63 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None Binds DNA by filter binding (PMID: 8441630), but competition assays suggest it is non-specific. A specific dsRNA structure is thought to be the preferred substrate. RNA-binding has been demonstrated by gel-shift experiments (PMID: 10329420).
UBA52 76 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
NPM1 90 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None No evidence for sequence-specific DNA-binding (PMID: 2223875)
YBX1 92 Yes Known motif Monomer or homomultimer High-throughput in vitro None Might also bind RNA
HNRNPA1 93 No ssDNA/RNA binding Not a DNA binding protein No motif None Binds single stranded DNA in the structure (PDB: 1PGZ)
RPL36A 107 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a ribosomal component
PHB2 117 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein has been shown to bind to TFs and function as a co-repressor. There appears to be no evidence for direct DNA-binding activity (PMID: 18629613)
COMMD6 139 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HMGB1 142 No Unlikely to be sequence specific TF Low specificity DNA-binding protein No motif None In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB½ are non-sequence-specific binding proteins (PMID: 11497996).
SOX11 146 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
ZNF428 158 Yes Likely to be sequence specific TF Monomer or homomultimer No motif Single C2H2 domain None
PHOX2B 160 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TWIST1 161 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Can form both homodimers and heterodimers with TCF3 (PMID: 16502419).
MYCN 185 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
EIF3K 191 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
UBB 216 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
HMGA1 222 Yes Known motif Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain None
PCBP2 226 No ssDNA/RNA binding Not a DNA binding protein No motif None Protein is an RBP. Structure (PDB:2PQU) is with single stranded DNA

Druggable Genes for this Gene Expression Program:

Gene Symbol Gene Loading Rank Drug Names Drug Category GTEx DepMap
TUBB2B 87
9VINCRISTINE, VINORELBINE BASE, ERIBULIN, CABAZITAXEL, IXABEPILONE, DOCETAXEL, COLCHICINE, PACLITAXEL, VINBLASTINE
 Small molecule GTEx DepMap
TUBB2B 87
2BRENTUXIMAB VEDOTIN, TRASTUZUMAB EMTANSINE
 Antibody GTEx DepMap
TUBB 99
9CABAZITAXEL, VINORELBINE BASE, VINCRISTINE, ERIBULIN, IXABEPILONE, DOCETAXEL, COLCHICINE, PACLITAXEL, VINBLASTINE
 Small molecule GTEx DepMap
TUBB 99
2BRENTUXIMAB VEDOTIN, TRASTUZUMAB EMTANSINE
 Antibody GTEx DepMap
IMPDH2 123
3MYCOPHENOLATE MOFETIL, MYCOPHENOLIC ACID, THIOGUANINE
 Small molecule GTEx DepMap
NDUFB11 127
1METFORMIN
 Small molecule GTEx DepMap
NDUFB7 154
1METFORMIN
 Small molecule GTEx DepMap
NDUFC2 204
1METFORMIN
 Small molecule GTEx DepMap
NDUFS5 251
1METFORMIN
 Small molecule GTEx DepMap
NDUFB10 256
1METFORMIN
 Small molecule GTEx DepMap
ODC1 263
1EFLORNITHINE
 Small molecule GTEx DepMap
HDAC2 276
4ROMIDEPSIN, PANOBINOSTAT, VORINOSTAT, BELINOSTAT
 Small molecule GTEx DepMap
NDUFB4 296
1METFORMIN
 Small molecule GTEx DepMap
NDUFB2 300
1METFORMIN
 Small molecule GTEx DepMap
NDUFB8 311
1METFORMIN
 Small molecule GTEx DepMap
NDUFA11 355
1METFORMIN
 Small molecule GTEx DepMap
NDUFS6 363
1METFORMIN
 Small molecule GTEx DepMap
MAP2K2 374
2COBIMETINIB, TRAMETINIB
 Small molecule GTEx DepMap
NDUFB1 391
1METFORMIN
 Small molecule GTEx DepMap
BSG 392
1GAVILIMOMAB
 Antibody GTEx DepMap
FASN 452
1ORLISTAT
 Small molecule GTEx DepMap
NDUFA2 459
1METFORMIN
 Small molecule GTEx DepMap


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
TACCTCGTCTGCTAGA-1_HTA4_1021_4082 Neurons 0.28 1828.95
Raw ScoresNeurons: 0.53, Neuroepithelial_cell: 0.47, Astrocyte: 0.47, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.36, Smooth_muscle_cells: 0.34, Fibroblasts: 0.34, Tissue_stem_cells: 0.33, Endothelial_cells: 0.33
GTTGTAGAGATGGCAC-1_HTA4_1021_4082 Neurons 0.27 777.92
Raw ScoresNeurons: 0.48, Neuroepithelial_cell: 0.44, Astrocyte: 0.41, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.31, Tissue_stem_cells: 0.28, Fibroblasts: 0.27, Endothelial_cells: 0.27, Smooth_muscle_cells: 0.26
GGAGAACGTGACAACG-1_HTA4_1021_4082 Neurons 0.29 758.19
Raw ScoresNeurons: 0.52, Neuroepithelial_cell: 0.47, Astrocyte: 0.46, Embryonic_stem_cells: 0.42, iPS_cells: 0.41, MSC: 0.36, Tissue_stem_cells: 0.32, Fibroblasts: 0.32, Endothelial_cells: 0.31, Smooth_muscle_cells: 0.31
TCCTCGAGTCAAGTTC-1_HTA4_1021_4082 Neurons 0.24 753.16
Raw ScoresNeurons: 0.43, Neuroepithelial_cell: 0.38, Astrocyte: 0.36, Embryonic_stem_cells: 0.34, iPS_cells: 0.34, MSC: 0.27, Fibroblasts: 0.26, Smooth_muscle_cells: 0.25, Endothelial_cells: 0.25, Osteoblasts: 0.25
GGTTGTACAACCGTAT-1_HTA4_1021_4082 Neurons 0.29 738.99
Raw ScoresNeurons: 0.53, Astrocyte: 0.46, Neuroepithelial_cell: 0.46, Embryonic_stem_cells: 0.41, iPS_cells: 0.4, MSC: 0.36, Smooth_muscle_cells: 0.33, Tissue_stem_cells: 0.33, Endothelial_cells: 0.32, Fibroblasts: 0.32
ACGGAAGCATCTGCGG-1_HTA4_1021_4082 Neuroepithelial_cell 0.11 683.27
Raw ScoresNeurons: 0.3, Neuroepithelial_cell: 0.29, Astrocyte: 0.28, Embryonic_stem_cells: 0.26, iPS_cells: 0.25, Smooth_muscle_cells: 0.23, MSC: 0.23, Fibroblasts: 0.22, Tissue_stem_cells: 0.22, Osteoblasts: 0.22
ATGGGTTAGTCCCAGC-1_HTA4_1021_4082 Neurons 0.20 680.01
Raw ScoresNeurons: 0.36, Neuroepithelial_cell: 0.32, Astrocyte: 0.31, Embryonic_stem_cells: 0.27, iPS_cells: 0.26, MSC: 0.21, Endothelial_cells: 0.2, Smooth_muscle_cells: 0.2, Fibroblasts: 0.2, Tissue_stem_cells: 0.19
ATTGGGTAGAGAGTTT-1_HTA4_1008_4030 Neurons 0.27 624.11
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.46, Astrocyte: 0.44, Embryonic_stem_cells: 0.43, iPS_cells: 0.41, MSC: 0.36, Tissue_stem_cells: 0.31, Endothelial_cells: 0.3, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3
TGTAACGGTGATAGAT-1_HTA4_1021_4082 Neurons 0.19 617.38
Raw ScoresNeurons: 0.33, Neuroepithelial_cell: 0.28, Astrocyte: 0.28, Embryonic_stem_cells: 0.25, iPS_cells: 0.24, MSC: 0.2, Smooth_muscle_cells: 0.2, Osteoblasts: 0.2, Chondrocytes: 0.2, Fibroblasts: 0.2
TCGCACTTCCTTGACC-1_HTA4_1021_4083 Neurons 0.13 569.32
Raw ScoresEndothelial_cells: 0.37, Neuroepithelial_cell: 0.35, Astrocyte: 0.34, Neurons: 0.34, MSC: 0.33, Fibroblasts: 0.33, Smooth_muscle_cells: 0.32, Osteoblasts: 0.32, Embryonic_stem_cells: 0.32, Tissue_stem_cells: 0.31
CTTCTCTTCTTCACAT-1_HTA4_1021_4083 Neurons 0.18 561.42
Raw ScoresNeurons: 0.3, Neuroepithelial_cell: 0.27, Astrocyte: 0.26, Embryonic_stem_cells: 0.24, iPS_cells: 0.23, MSC: 0.21, Tissue_stem_cells: 0.18, Endothelial_cells: 0.18, Fibroblasts: 0.18, Smooth_muscle_cells: 0.17
TCCCACACACGGTGTC-1_HTA4_1005_4018 Neurons 0.26 524.24
Raw ScoresNeurons: 0.39, Astrocyte: 0.35, Neuroepithelial_cell: 0.34, Embryonic_stem_cells: 0.29, iPS_cells: 0.28, MSC: 0.23, Smooth_muscle_cells: 0.22, Osteoblasts: 0.21, Fibroblasts: 0.21, Chondrocytes: 0.2
CCGATGGGTCGAGCTC-1_HTA4_1021_4083 Neurons 0.21 488.19
Raw ScoresNeurons: 0.38, Neuroepithelial_cell: 0.33, Astrocyte: 0.32, Embryonic_stem_cells: 0.29, iPS_cells: 0.28, MSC: 0.25, Fibroblasts: 0.22, Endothelial_cells: 0.22, Smooth_muscle_cells: 0.22, Tissue_stem_cells: 0.21
GGTGTTATCGTTGTAG-1_HTA4_1021_4082 Neurons 0.21 470.71
Raw ScoresNeurons: 0.4, Neuroepithelial_cell: 0.34, Astrocyte: 0.33, iPS_cells: 0.3, Embryonic_stem_cells: 0.3, MSC: 0.24, Fibroblasts: 0.23, Smooth_muscle_cells: 0.23, Endothelial_cells: 0.23, Osteoblasts: 0.23
TACGCTCAGAGGCGTT-1_HTA4_1021_4082 Neurons 0.20 465.81
Raw ScoresNeurons: 0.39, Neuroepithelial_cell: 0.35, Astrocyte: 0.33, Embryonic_stem_cells: 0.31, iPS_cells: 0.3, MSC: 0.25, Endothelial_cells: 0.22, Tissue_stem_cells: 0.22, Fibroblasts: 0.21, Pro-B_cell_CD34+: 0.21
TCTATCAAGAAACTAC-1_HTA4_1001_4004 Smooth_muscle_cells 0.15 465.58
Raw ScoresFibroblasts: 0.44, Smooth_muscle_cells: 0.44, Osteoblasts: 0.42, Tissue_stem_cells: 0.42, MSC: 0.42, Chondrocytes: 0.41, Endothelial_cells: 0.41, iPS_cells: 0.41, Astrocyte: 0.4, Neurons: 0.4
GATTCTTCAGAAGTGC-1_HTA4_1021_4082 Neurons 0.21 451.99
Raw ScoresNeurons: 0.39, Neuroepithelial_cell: 0.35, Astrocyte: 0.33, Embryonic_stem_cells: 0.3, iPS_cells: 0.3, MSC: 0.25, Endothelial_cells: 0.24, Smooth_muscle_cells: 0.23, Tissue_stem_cells: 0.23, Fibroblasts: 0.22
TCACGGGCATACTGAC-1_HTA4_1021_4082 Neurons 0.11 449.01
Raw ScoresNeurons: 0.23, Neuroepithelial_cell: 0.21, iPS_cells: 0.2, Embryonic_stem_cells: 0.2, Astrocyte: 0.2, MSC: 0.17, Endothelial_cells: 0.15, Smooth_muscle_cells: 0.15, Tissue_stem_cells: 0.15, Fibroblasts: 0.14
GAGAGGTCAACTTGCA-1_HTA4_1021_4082 Neurons 0.15 448.57
Raw ScoresNeurons: 0.29, Neuroepithelial_cell: 0.27, Astrocyte: 0.26, Embryonic_stem_cells: 0.24, iPS_cells: 0.22, MSC: 0.2, Endothelial_cells: 0.19, Fibroblasts: 0.19, Smooth_muscle_cells: 0.18, Chondrocytes: 0.18
CTACAGAAGGTACAAT-1_HTA4_1021_4083 Neurons 0.13 441.79
Raw ScoresNeurons: 0.3, Neuroepithelial_cell: 0.27, Embryonic_stem_cells: 0.25, iPS_cells: 0.24, Astrocyte: 0.24, MSC: 0.21, Endothelial_cells: 0.19, Fibroblasts: 0.19, Pro-B_cell_CD34+: 0.19, CMP: 0.18
GAGGGTAGTCTAGGTT-1_HTA4_1021_4082 Neurons 0.18 437.57
Raw ScoresNeurons: 0.32, Neuroepithelial_cell: 0.27, Astrocyte: 0.26, Embryonic_stem_cells: 0.24, iPS_cells: 0.23, MSC: 0.21, Endothelial_cells: 0.19, Smooth_muscle_cells: 0.19, Fibroblasts: 0.19, Tissue_stem_cells: 0.19
CTTCTAACAAACTCTG-1_HTA4_1008_4030 Neurons 0.28 434.67
Raw ScoresNeurons: 0.5, Neuroepithelial_cell: 0.45, Astrocyte: 0.43, Embryonic_stem_cells: 0.4, iPS_cells: 0.38, MSC: 0.35, Tissue_stem_cells: 0.31, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3, Endothelial_cells: 0.3
ATTCTTGTCACAGAGG-1_HTA4_1001_4004 Smooth_muscle_cells 0.14 431.53
Raw ScoresFibroblasts: 0.44, Smooth_muscle_cells: 0.43, Tissue_stem_cells: 0.42, MSC: 0.42, Osteoblasts: 0.42, Astrocyte: 0.41, iPS_cells: 0.41, Chondrocytes: 0.41, Neurons: 0.41, Endothelial_cells: 0.4
GTTACGACAAAGTGTA-1_HTA4_1021_4082 Neurons 0.13 417.79
Raw ScoresNeurons: 0.22, Astrocyte: 0.21, Neuroepithelial_cell: 0.2, Embryonic_stem_cells: 0.16, iPS_cells: 0.16, Smooth_muscle_cells: 0.13, MSC: 0.13, Endothelial_cells: 0.12, Chondrocytes: 0.11, Tissue_stem_cells: 0.11
AACTTCTTCTGTGTGA-1_HTA4_1021_4082 Neurons 0.22 416.78
Raw ScoresNeurons: 0.42, Neuroepithelial_cell: 0.36, Astrocyte: 0.34, Embryonic_stem_cells: 0.32, iPS_cells: 0.32, MSC: 0.27, Endothelial_cells: 0.26, Smooth_muscle_cells: 0.25, Fibroblasts: 0.25, Tissue_stem_cells: 0.24
CCAATGAAGCGCCGTT-1_HTA4_1021_4083 Neurons 0.25 416.29
Raw ScoresNeurons: 0.43, Neuroepithelial_cell: 0.38, Astrocyte: 0.37, Embryonic_stem_cells: 0.34, iPS_cells: 0.33, MSC: 0.28, Smooth_muscle_cells: 0.25, Endothelial_cells: 0.25, Fibroblasts: 0.25, Tissue_stem_cells: 0.25
TTACCGCAGATAGTCA-1_HTA4_1021_4082 Neurons 0.27 415.46
Raw ScoresNeurons: 0.48, Astrocyte: 0.44, Neuroepithelial_cell: 0.43, Embryonic_stem_cells: 0.37, iPS_cells: 0.35, MSC: 0.33, Fibroblasts: 0.32, Smooth_muscle_cells: 0.32, Endothelial_cells: 0.31, Osteoblasts: 0.31
AGTCACAAGACCAAAT-1_HTA4_1005_4018 Neurons 0.23 413.87
Raw ScoresNeurons: 0.36, Neuroepithelial_cell: 0.35, Astrocyte: 0.33, Embryonic_stem_cells: 0.29, iPS_cells: 0.28, MSC: 0.23, Smooth_muscle_cells: 0.22, Osteoblasts: 0.22, Fibroblasts: 0.21, Chondrocytes: 0.2
TGGTAGTCAACTCCAA-1_HTA4_1021_4082 Neurons 0.23 412.40
Raw ScoresNeurons: 0.42, Neuroepithelial_cell: 0.37, Astrocyte: 0.37, Embryonic_stem_cells: 0.32, iPS_cells: 0.31, MSC: 0.27, Endothelial_cells: 0.25, Smooth_muscle_cells: 0.24, Tissue_stem_cells: 0.23, Fibroblasts: 0.23
TCCCATGAGCGGTAAC-1_HTA4_1010_4035 Neurons 0.21 409.32
Raw ScoresNeurons: 0.34, Neuroepithelial_cell: 0.29, Astrocyte: 0.28, Embryonic_stem_cells: 0.25, iPS_cells: 0.23, Smooth_muscle_cells: 0.21, MSC: 0.21, Endothelial_cells: 0.2, Fibroblasts: 0.2, Osteoblasts: 0.19
AGTCATGCATTCGGGC-1_HTA4_1021_4082 Neurons 0.17 401.65
Raw ScoresNeurons: 0.3, Neuroepithelial_cell: 0.27, Astrocyte: 0.24, Embryonic_stem_cells: 0.24, iPS_cells: 0.23, MSC: 0.19, Fibroblasts: 0.17, Tissue_stem_cells: 0.16, Smooth_muscle_cells: 0.16, Endothelial_cells: 0.15
GTCTTTACAGATTCGT-1_HTA4_1021_4082 Neurons 0.21 397.34
Raw ScoresNeurons: 0.36, Neuroepithelial_cell: 0.32, Astrocyte: 0.3, Embryonic_stem_cells: 0.27, iPS_cells: 0.26, MSC: 0.23, Fibroblasts: 0.22, Osteoblasts: 0.21, Smooth_muscle_cells: 0.21, Tissue_stem_cells: 0.2
TCTAACTGTTGTCAGT-1_HTA4_1021_4082 Neurons 0.19 394.39
Raw ScoresNeurons: 0.33, Neuroepithelial_cell: 0.28, Astrocyte: 0.27, Embryonic_stem_cells: 0.25, iPS_cells: 0.23, MSC: 0.2, Smooth_muscle_cells: 0.19, Endothelial_cells: 0.18, Tissue_stem_cells: 0.18, Fibroblasts: 0.17
TTCCGGTGTCATAAAG-1_HTA4_1021_4082 Neurons 0.21 394.35
Raw ScoresNeurons: 0.41, Neuroepithelial_cell: 0.36, Astrocyte: 0.35, Embryonic_stem_cells: 0.33, iPS_cells: 0.32, MSC: 0.27, Fibroblasts: 0.26, Smooth_muscle_cells: 0.26, Endothelial_cells: 0.26, Tissue_stem_cells: 0.25
ATACCTTTCCCTATTA-1_HTA4_1021_4082 Neurons 0.21 378.31
Raw ScoresNeurons: 0.36, Neuroepithelial_cell: 0.32, Astrocyte: 0.29, Embryonic_stem_cells: 0.27, iPS_cells: 0.27, MSC: 0.22, Smooth_muscle_cells: 0.19, Fibroblasts: 0.19, Endothelial_cells: 0.19, Tissue_stem_cells: 0.19
AGAGCAGGTACTAACC-1_HTA4_1021_4083 Neurons 0.23 376.12
Raw ScoresNeurons: 0.4, Neuroepithelial_cell: 0.35, Astrocyte: 0.34, Embryonic_stem_cells: 0.31, iPS_cells: 0.3, MSC: 0.25, Endothelial_cells: 0.23, Tissue_stem_cells: 0.23, Fibroblasts: 0.23, Smooth_muscle_cells: 0.22
ACGGAAGGTTACGGAG-1_HTA4_1008_4027 Neurons 0.27 370.48
Raw ScoresNeurons: 0.47, Neuroepithelial_cell: 0.41, Astrocyte: 0.4, Embryonic_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.31, Smooth_muscle_cells: 0.28, Tissue_stem_cells: 0.27, Fibroblasts: 0.27, Endothelial_cells: 0.27
GATGTTGTCCTCTCGA-1_HTA4_1021_4083 Neurons 0.16 369.49
Raw ScoresNeurons: 0.32, Neuroepithelial_cell: 0.31, Astrocyte: 0.28, Embryonic_stem_cells: 0.27, iPS_cells: 0.26, MSC: 0.22, Fibroblasts: 0.21, Endothelial_cells: 0.2, Smooth_muscle_cells: 0.2, Tissue_stem_cells: 0.2
ATTCGTTCACGCCACA-1_HTA4_1021_4082 Neurons 0.24 368.09
Raw ScoresNeurons: 0.44, Neuroepithelial_cell: 0.4, Astrocyte: 0.38, Embryonic_stem_cells: 0.34, iPS_cells: 0.33, MSC: 0.28, Endothelial_cells: 0.26, Tissue_stem_cells: 0.24, Fibroblasts: 0.24, Smooth_muscle_cells: 0.23
TGTTCATCAATCAGCT-1_HTA4_1021_4082 Neurons 0.24 362.96
Raw ScoresNeurons: 0.42, Neuroepithelial_cell: 0.38, Astrocyte: 0.37, Embryonic_stem_cells: 0.33, iPS_cells: 0.32, MSC: 0.27, Tissue_stem_cells: 0.24, Smooth_muscle_cells: 0.24, Endothelial_cells: 0.24, Fibroblasts: 0.23
CGCAGGTGTAGCCCTG-1_HTA4_1021_4083 Neurons 0.24 352.52
Raw ScoresNeurons: 0.43, Neuroepithelial_cell: 0.39, Astrocyte: 0.37, Embryonic_stem_cells: 0.34, iPS_cells: 0.33, MSC: 0.28, Fibroblasts: 0.26, Smooth_muscle_cells: 0.26, Tissue_stem_cells: 0.26, Osteoblasts: 0.25
TCGCTCAGTGTTACTG-1_HTA4_1021_4082 Neurons 0.20 351.37
Raw ScoresNeurons: 0.38, Neuroepithelial_cell: 0.34, Astrocyte: 0.31, Embryonic_stem_cells: 0.3, iPS_cells: 0.29, MSC: 0.25, Endothelial_cells: 0.22, Smooth_muscle_cells: 0.21, Tissue_stem_cells: 0.21, Fibroblasts: 0.21
GGTGATTAGCCTCTGG-1_HTA4_1021_4082 Neurons 0.21 348.35
Raw ScoresNeurons: 0.36, Neuroepithelial_cell: 0.33, Astrocyte: 0.32, Embryonic_stem_cells: 0.28, iPS_cells: 0.26, MSC: 0.24, Smooth_muscle_cells: 0.21, Tissue_stem_cells: 0.21, Fibroblasts: 0.21, Endothelial_cells: 0.2
TTGAACGAGGTAGATT-1_HTA4_1021_4083 Neurons 0.18 345.50
Raw ScoresNeurons: 0.34, Neuroepithelial_cell: 0.31, Astrocyte: 0.28, Embryonic_stem_cells: 0.26, iPS_cells: 0.25, MSC: 0.22, Endothelial_cells: 0.2, Smooth_muscle_cells: 0.2, Tissue_stem_cells: 0.19, Fibroblasts: 0.18
TGCTTCGTCGGCGATC-1_HTA4_1021_4083 Neurons 0.22 343.61
Raw ScoresNeurons: 0.41, Neuroepithelial_cell: 0.37, Astrocyte: 0.36, Embryonic_stem_cells: 0.33, iPS_cells: 0.32, MSC: 0.27, Endothelial_cells: 0.24, Smooth_muscle_cells: 0.24, Fibroblasts: 0.24, Tissue_stem_cells: 0.24
GTGCGTGCAACTACGT-1_HTA4_1010_4035 Neurons 0.20 335.34
Raw ScoresNeurons: 0.31, Neuroepithelial_cell: 0.28, Astrocyte: 0.27, Embryonic_stem_cells: 0.24, iPS_cells: 0.23, MSC: 0.2, Smooth_muscle_cells: 0.18, Fibroblasts: 0.18, Osteoblasts: 0.17, Endothelial_cells: 0.17
CAGCGTGCAGACATCT-1_HTA4_1008_4028 Neurons 0.29 335.33
Raw ScoresNeurons: 0.51, Neuroepithelial_cell: 0.47, Astrocyte: 0.45, Embryonic_stem_cells: 0.42, iPS_cells: 0.4, MSC: 0.36, Tissue_stem_cells: 0.32, Endothelial_cells: 0.3, Fibroblasts: 0.3, Smooth_muscle_cells: 0.3
GTCATTTAGCATATGA-1_HTA4_1021_4082 Neurons 0.16 332.96
Raw ScoresNeurons: 0.28, Neuroepithelial_cell: 0.25, Astrocyte: 0.23, Embryonic_stem_cells: 0.22, iPS_cells: 0.21, MSC: 0.18, Endothelial_cells: 0.18, Fibroblasts: 0.17, Smooth_muscle_cells: 0.17, Osteoblasts: 0.17
GGGACAATCAGGTAAA-1_HTA4_1021_4082 Neurons 0.25 323.89
Raw ScoresNeurons: 0.41, Neuroepithelial_cell: 0.37, Astrocyte: 0.35, Embryonic_stem_cells: 0.32, iPS_cells: 0.3, MSC: 0.26, Endothelial_cells: 0.24, Smooth_muscle_cells: 0.24, Fibroblasts: 0.23, Tissue_stem_cells: 0.23
TGCTTGCAGCGAGTCA-1_HTA4_1021_4082 Neurons 0.24 320.46
Raw ScoresNeurons: 0.46, Neuroepithelial_cell: 0.4, Astrocyte: 0.39, Embryonic_stem_cells: 0.35, iPS_cells: 0.34, MSC: 0.29, Endothelial_cells: 0.27, Fibroblasts: 0.27, Tissue_stem_cells: 0.27, Smooth_muscle_cells: 0.26


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Proliferating Cells
These are canonical marker genes of cycling cells, obtained from Fig. 3 of Hsiao et al. (PMID 32312741):
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.05e-05
Mean rank of genes in gene set: 1210.67
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
H4C3 0.0058577 89 GTEx DepMap Descartes 0.66 NA
UBE2C 0.0013856 688 GTEx DepMap Descartes 0.25 190.35
TOP2A 0.0010713 989 GTEx DepMap Descartes 0.79 88.56
MKI67 0.0006942 1645 GTEx DepMap Descartes 0.28 14.02
H4C5 0.0006049 1882 GTEx DepMap Descartes 0.03 NA
CDK1 0.0005713 1971 GTEx DepMap Descartes 0.18 59.72


Neuroblast (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Neuroblast subcluster, which is part of the Adrenal Medulla cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.16e-04
Mean rank of genes in gene set: 4228.92
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
STMN1 0.0044213 114 GTEx DepMap Descartes 2.61 535.43
STMN2 0.0033906 159 GTEx DepMap Descartes 8.67 2137.58
BASP1 0.0033407 166 GTEx DepMap Descartes 2.71 809.68
CCND1 0.0032207 181 GTEx DepMap Descartes 2.62 340.49
ISL1 0.0021995 339 GTEx DepMap Descartes 0.94 221.35
INA 0.0018520 450 GTEx DepMap Descartes 0.55 89.12
ELAVL4 0.0016600 527 GTEx DepMap Descartes 3.08 368.17
ELAVL3 0.0010804 978 GTEx DepMap Descartes 1.41 148.04
RTN1 0.0009450 1162 GTEx DepMap Descartes 2.42 338.82
TUBB3 0.0001827 4050 GTEx DepMap Descartes 0.03 6.29
NEFM 0.0000023 6470 GTEx DepMap Descartes 0.84 104.26
NEFL -0.0013195 19903 GTEx DepMap Descartes 1.19 103.59
PRPH -0.0019761 20477 GTEx DepMap Descartes 1.52 247.51


Adrenal Premordium (Hanemaaijer)
Marker genes obtained from Supplementary Table SD of Hanemaaijer et al (PMID 33500353). The authors generated single-cell RNA-seq data (sort-seq, 2,229 cells total) from mouse adrenal glads at E13.5, E14.5, E17.5, E18.5, P1 and P5. These were marker genes that matched with a similar dataset generated by Furlan et al (PMID 28684471). This particular set of markers are for the Adrenal Premordium subcluster, which is part of the Cortex cluster.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.23e-04
Mean rank of genes in gene set: 548.6
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RPS2 0.0160635 3 GTEx DepMap Descartes 10.51 4193.09
NPM1 0.0058507 90 GTEx DepMap Descartes 1.91 626.54
MIF 0.0028128 225 GTEx DepMap Descartes 0.46 265.30
TPI1 0.0027771 229 GTEx DepMap Descartes 0.95 294.00
TK1 0.0005089 2196 GTEx DepMap Descartes 0.09 32.69




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.42e-18
Mean rank of genes in gene set: 7578.86
Median rank of genes in gene set: 3750
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TUBB2B 0.0060284 87 GTEx DepMap Descartes 3.63 1054.34
DLK1 0.0058787 88 GTEx DepMap Descartes 1.42 166.70
EEF1A2 0.0051036 100 GTEx DepMap Descartes 2.05 270.68
CCNI 0.0040684 129 GTEx DepMap Descartes 2.32 468.11
SOX11 0.0035339 146 GTEx DepMap Descartes 2.22 145.51
CKB 0.0035270 147 GTEx DepMap Descartes 1.20 446.28
STMN2 0.0033906 159 GTEx DepMap Descartes 8.67 2137.58
PHOX2B 0.0033789 160 GTEx DepMap Descartes 1.63 332.46
NPY 0.0032694 171 GTEx DepMap Descartes 3.49 2692.04
RANBP1 0.0032601 172 GTEx DepMap Descartes 0.74 211.20
CCND1 0.0032207 181 GTEx DepMap Descartes 2.62 340.49
EIF1B 0.0032012 182 GTEx DepMap Descartes 0.72 360.93
CHGA 0.0029321 211 GTEx DepMap Descartes 1.08 286.09
HNRNPA0 0.0028918 215 GTEx DepMap Descartes 0.73 45.96
HMGA1 0.0028512 222 GTEx DepMap Descartes 0.42 122.03
FABP6 0.0026956 245 GTEx DepMap Descartes 0.31 199.47
GDAP1L1 0.0026847 247 GTEx DepMap Descartes 0.56 105.11
LSM3 0.0026671 249 GTEx DepMap Descartes 0.40 64.74
C4orf48 0.0026335 252 GTEx DepMap Descartes 0.94 1001.73
PHPT1 0.0025992 255 GTEx DepMap Descartes 0.65 262.82
GAL 0.0025011 267 GTEx DepMap Descartes 2.19 1228.63
RBP1 0.0023971 290 GTEx DepMap Descartes 0.53 137.11
RGS5 0.0023335 307 GTEx DepMap Descartes 2.31 203.77
DCX 0.0022537 326 GTEx DepMap Descartes 0.77 45.02
ISL1 0.0021995 339 GTEx DepMap Descartes 0.94 221.35
LSM4 0.0021670 348 GTEx DepMap Descartes 0.64 207.05
STMN4 0.0021356 357 GTEx DepMap Descartes 1.07 232.45
CENPV 0.0020648 381 GTEx DepMap Descartes 0.60 184.95
GATA3 0.0020082 387 GTEx DepMap Descartes 1.66 297.09
NNAT 0.0019935 396 GTEx DepMap Descartes 0.61 245.78


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13268.98
Median rank of genes in gene set: 15809.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PPIB 0.0022381 330 GTEx DepMap Descartes 0.66 258.76
VIM 0.0021859 341 GTEx DepMap Descartes 2.10 383.15
PRDX4 0.0019206 414 GTEx DepMap Descartes 0.32 179.17
CD63 0.0015854 567 GTEx DepMap Descartes 1.79 693.59
POLR2L 0.0015596 586 GTEx DepMap Descartes 0.40 215.04
DDOST 0.0014853 621 GTEx DepMap Descartes 0.40 98.74
LAPTM4A 0.0014533 636 GTEx DepMap Descartes 0.75 271.06
PDIA6 0.0013814 693 GTEx DepMap Descartes 0.78 140.98
MANF 0.0013436 731 GTEx DepMap Descartes 0.29 94.67
PRDX6 0.0013407 734 GTEx DepMap Descartes 0.57 164.07
MYDGF 0.0013157 755 GTEx DepMap Descartes 0.38 NA
OSTC 0.0012519 807 GTEx DepMap Descartes 0.45 214.61
ROBO1 0.0011186 932 GTEx DepMap Descartes 10.33 792.53
MYL12B 0.0010901 969 GTEx DepMap Descartes 0.88 305.55
EMILIN1 0.0010722 986 GTEx DepMap Descartes 0.39 54.77
MYL12A 0.0009971 1092 GTEx DepMap Descartes 0.34 126.30
LHX8 0.0009369 1173 GTEx DepMap Descartes 0.04 6.63
SOX9 0.0009099 1225 GTEx DepMap Descartes 0.12 17.65
LGALS1 0.0008972 1243 GTEx DepMap Descartes 1.23 756.80
ABRACL 0.0008564 1314 GTEx DepMap Descartes 0.13 NA
SSBP4 0.0007929 1434 GTEx DepMap Descartes 0.58 156.84
SCRG1 0.0007852 1450 GTEx DepMap Descartes 0.12 14.56
HLA-C 0.0007423 1544 GTEx DepMap Descartes 0.31 65.13
TRIL 0.0007363 1555 GTEx DepMap Descartes 0.11 9.51
GJA1 0.0007224 1579 GTEx DepMap Descartes 0.20 18.63
MEST 0.0007036 1617 GTEx DepMap Descartes 0.43 83.02
TMED9 0.0006838 1671 GTEx DepMap Descartes 0.27 46.01
SSR3 0.0006692 1701 GTEx DepMap Descartes 0.42 52.41
KDM5B 0.0006619 1726 GTEx DepMap Descartes 1.09 56.70
TMBIM4 0.0005434 2062 GTEx DepMap Descartes 0.08 11.76


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13254.64
Median rank of genes in gene set: 16788
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HSPE1 0.0032458 174 GTEx DepMap Descartes 0.86 594.01
HSPD1 0.0027663 234 GTEx DepMap Descartes 2.09 437.23
SGCZ 0.0019905 397 GTEx DepMap Descartes 16.20 1299.50
CYP21A2 0.0013136 758 GTEx DepMap Descartes 0.58 63.58
FDXR 0.0010164 1058 GTEx DepMap Descartes 0.16 22.27
CYP17A1 0.0006888 1658 GTEx DepMap Descartes 0.46 55.33
TM7SF2 0.0005040 2217 GTEx DepMap Descartes 0.21 41.56
STAR 0.0003674 2830 GTEx DepMap Descartes 0.67 48.97
GSTA4 0.0002906 3278 GTEx DepMap Descartes 0.59 140.85
DHCR7 0.0001331 4462 GTEx DepMap Descartes 0.12 18.50
PEG3 0.0000508 5437 GTEx DepMap Descartes 0.01 NA
INHA 0.0000459 5520 GTEx DepMap Descartes 0.03 6.43
CYB5B -0.0000231 8062 GTEx DepMap Descartes 0.60 51.15
JAKMIP2 -0.0000863 10247 GTEx DepMap Descartes 1.40 64.35
FDX1 -0.0002426 13273 GTEx DepMap Descartes 1.84 151.99
HMGCR -0.0002580 13496 GTEx DepMap Descartes 0.58 50.42
DHCR24 -0.0003187 14260 GTEx DepMap Descartes 0.57 31.80
MC2R -0.0004303 15493 GTEx DepMap Descartes 0.14 9.37
SLC16A9 -0.0004346 15537 GTEx DepMap Descartes 0.45 41.36
FREM2 -0.0004410 15592 GTEx DepMap Descartes 0.04 0.71
CYP11B1 -0.0004874 16024 GTEx DepMap Descartes 1.05 66.64
SLC1A2 -0.0005521 16525 GTEx DepMap Descartes 0.79 29.73
DNER -0.0005833 16788 GTEx DepMap Descartes 0.70 70.43
MSMO1 -0.0006205 17057 GTEx DepMap Descartes 0.44 76.95
FDPS -0.0006344 17153 GTEx DepMap Descartes 0.91 177.88
SLC2A14 -0.0006419 17215 GTEx DepMap Descartes 0.05 3.69
SCAP -0.0006791 17475 GTEx DepMap Descartes 0.62 60.18
APOC1 -0.0007265 17757 GTEx DepMap Descartes 0.24 111.92
NPC1 -0.0007315 17778 GTEx DepMap Descartes 0.49 38.93
FRMD5 -0.0007472 17875 GTEx DepMap Descartes 2.91 241.29


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.27e-02
Mean rank of genes in gene set: 8271.07
Median rank of genes in gene set: 4288
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TUBB2B 0.0060284 87 GTEx DepMap Descartes 3.63 1054.34
STMN2 0.0033906 159 GTEx DepMap Descartes 8.67 2137.58
BASP1 0.0033407 166 GTEx DepMap Descartes 2.71 809.68
NPY 0.0032694 171 GTEx DepMap Descartes 3.49 2692.04
CCND1 0.0032207 181 GTEx DepMap Descartes 2.62 340.49
MAB21L2 0.0031090 193 GTEx DepMap Descartes 0.30 81.67
TUBA1A 0.0029708 206 GTEx DepMap Descartes 8.21 2186.52
GAL 0.0025011 267 GTEx DepMap Descartes 2.19 1228.63
ISL1 0.0021995 339 GTEx DepMap Descartes 0.94 221.35
MAB21L1 0.0021786 343 GTEx DepMap Descartes 0.40 77.67
STMN4 0.0021356 357 GTEx DepMap Descartes 1.07 232.45
ELAVL2 0.0015620 580 GTEx DepMap Descartes 2.12 271.78
EPHA6 0.0012351 831 GTEx DepMap Descartes 4.28 501.55
EYA1 0.0009188 1206 GTEx DepMap Descartes 2.51 295.72
KCNB2 0.0008401 1341 GTEx DepMap Descartes 3.15 422.06
MLLT11 0.0007508 1523 GTEx DepMap Descartes 1.16 236.24
RGMB 0.0005230 2131 GTEx DepMap Descartes 0.49 48.68
HS3ST5 0.0005131 2176 GTEx DepMap Descartes 0.82 82.80
FAT3 0.0004965 2255 GTEx DepMap Descartes 1.06 30.01
IL7 0.0003945 2684 GTEx DepMap Descartes 2.18 421.32
CNTFR 0.0002635 3428 GTEx DepMap Descartes 0.34 70.87
SLC44A5 0.0001527 4288 GTEx DepMap Descartes 1.53 154.10
TMEFF2 0.0001485 4331 GTEx DepMap Descartes 0.85 101.14
HMX1 0.0000676 5225 GTEx DepMap Descartes 0.55 126.37
PTCHD1 -0.0000483 9085 GTEx DepMap Descartes 0.46 13.01
GREM1 -0.0000819 10134 GTEx DepMap Descartes 0.06 1.12
SYNPO2 -0.0002190 12943 GTEx DepMap Descartes 1.17 38.91
EYA4 -0.0003712 14863 GTEx DepMap Descartes 0.46 33.23
CNKSR2 -0.0003809 14966 GTEx DepMap Descartes 1.51 77.70
RYR2 -0.0003935 15093 GTEx DepMap Descartes 5.89 146.61


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.74e-01
Mean rank of genes in gene set: 12036.43
Median rank of genes in gene set: 12679
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RAMP2 0.0014511 638 GTEx DepMap Descartes 0.23 133.43
HYAL2 0.0009651 1133 GTEx DepMap Descartes 0.22 25.47
EFNB2 0.0003562 2899 GTEx DepMap Descartes 0.46 46.26
ESM1 0.0002731 3375 GTEx DepMap Descartes 0.06 12.93
SOX18 0.0002120 3797 GTEx DepMap Descartes 0.09 18.85
ID1 0.0001867 4014 GTEx DepMap Descartes 0.23 67.67
ARHGAP29 0.0001718 4129 GTEx DepMap Descartes 0.99 54.48
CHRM3 0.0001405 4402 GTEx DepMap Descartes 1.55 81.31
CLDN5 0.0000946 4875 GTEx DepMap Descartes 0.09 14.39
IRX3 0.0000540 5389 GTEx DepMap Descartes 0.02 3.71
TM4SF18 0.0000351 5689 GTEx DepMap Descartes 0.04 4.41
TMEM88 -0.0000451 8963 GTEx DepMap Descartes 0.04 18.14
CYP26B1 -0.0000634 9595 GTEx DepMap Descartes 0.02 2.44
APLNR -0.0000792 10056 GTEx DepMap Descartes 0.03 3.77
ECSCR -0.0000797 10070 GTEx DepMap Descartes 0.00 0.06
NPR1 -0.0000869 10261 GTEx DepMap Descartes 0.02 1.90
PODXL -0.0001359 11453 GTEx DepMap Descartes 0.27 18.40
MMRN2 -0.0001505 11744 GTEx DepMap Descartes 0.09 8.59
DNASE1L3 -0.0001668 12043 GTEx DepMap Descartes 0.06 11.75
KDR -0.0001878 12415 GTEx DepMap Descartes 0.07 5.19
TIE1 -0.0001955 12544 GTEx DepMap Descartes 0.06 5.72
CRHBP -0.0001987 12598 GTEx DepMap Descartes 0.02 3.10
PLVAP -0.0002086 12760 GTEx DepMap Descartes 0.16 28.73
ROBO4 -0.0002371 13206 GTEx DepMap Descartes 0.05 4.63
RASIP1 -0.0003175 14247 GTEx DepMap Descartes 0.06 7.06
FLT4 -0.0003191 14264 GTEx DepMap Descartes 0.03 2.02
KANK3 -0.0003643 14806 GTEx DepMap Descartes 0.05 6.65
CDH5 -0.0003944 15112 GTEx DepMap Descartes 0.08 7.21
FCGR2B -0.0003981 15144 GTEx DepMap Descartes 0.01 0.94
BTNL9 -0.0003988 15153 GTEx DepMap Descartes 0.06 5.98


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13527.55
Median rank of genes in gene set: 15189
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
PCOLCE 0.0016862 518 GTEx DepMap Descartes 0.61 217.22
PCDH18 0.0003882 2720 GTEx DepMap Descartes 0.06 5.08
CD248 0.0002476 3545 GTEx DepMap Descartes 0.05 10.40
MGP 0.0002353 3621 GTEx DepMap Descartes 1.49 334.95
ZNF385D 0.0001700 4148 GTEx DepMap Descartes 0.85 33.02
C7 0.0001411 4393 GTEx DepMap Descartes 0.71 48.58
POSTN 0.0001219 4564 GTEx DepMap Descartes 0.57 66.78
DKK2 0.0000918 4917 GTEx DepMap Descartes 0.15 19.00
SFRP2 -0.0000508 9164 GTEx DepMap Descartes 0.26 62.62
LRRC17 -0.0000514 9182 GTEx DepMap Descartes 0.09 19.22
CLDN11 -0.0000621 9552 GTEx DepMap Descartes 0.00 0.01
SULT1E1 -0.0000702 9806 GTEx DepMap Descartes 0.00 0.33
OGN -0.0001345 11420 GTEx DepMap Descartes 0.12 13.72
RSPO3 -0.0001553 11826 GTEx DepMap Descartes 0.03 NA
HHIP -0.0002344 13160 GTEx DepMap Descartes 0.33 15.34
PRRX1 -0.0002529 13426 GTEx DepMap Descartes 0.19 17.20
SCARA5 -0.0002632 13559 GTEx DepMap Descartes 0.01 0.71
DCN -0.0002647 13590 GTEx DepMap Descartes 0.45 23.50
MXRA5 -0.0002717 13681 GTEx DepMap Descartes 0.06 1.99
PAMR1 -0.0002946 13969 GTEx DepMap Descartes 0.19 19.44
PDGFRA -0.0003242 14329 GTEx DepMap Descartes 0.06 4.33
ACTA2 -0.0003297 14404 GTEx DepMap Descartes 0.36 99.62
EDNRA -0.0003766 14916 GTEx DepMap Descartes 0.15 13.27
LAMC3 -0.0003814 14969 GTEx DepMap Descartes 0.07 2.63
COL6A3 -0.0004026 15189 GTEx DepMap Descartes 0.55 22.07
COL3A1 -0.0004030 15196 GTEx DepMap Descartes 2.41 175.28
FNDC1 -0.0004550 15716 GTEx DepMap Descartes 0.06 3.65
LUM -0.0004707 15865 GTEx DepMap Descartes 0.44 65.96
IGFBP3 -0.0004831 15984 GTEx DepMap Descartes 0.17 24.62
ABCC9 -0.0004877 16028 GTEx DepMap Descartes 0.09 4.01


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.03e-01
Mean rank of genes in gene set: 10071.77
Median rank of genes in gene set: 12749
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CHGA 0.0029321 211 GTEx DepMap Descartes 1.08 286.09
CHGB 0.0018495 453 GTEx DepMap Descartes 3.47 692.19
GALNTL6 0.0015246 602 GTEx DepMap Descartes 2.12 263.86
HTATSF1 0.0014319 654 GTEx DepMap Descartes 0.35 62.19
PCSK1N 0.0013866 687 GTEx DepMap Descartes 2.59 993.66
KCTD16 0.0013853 689 GTEx DepMap Descartes 3.64 110.54
INSM1 0.0013380 737 GTEx DepMap Descartes 0.18 33.13
TENM1 0.0011495 900 GTEx DepMap Descartes 1.22 NA
ROBO1 0.0011186 932 GTEx DepMap Descartes 10.33 792.53
C1QL1 0.0010504 1012 GTEx DepMap Descartes 0.13 47.35
PCSK2 0.0007568 1512 GTEx DepMap Descartes 0.75 62.98
PENK 0.0007564 1513 GTEx DepMap Descartes 0.05 24.68
SPOCK3 0.0006324 1808 GTEx DepMap Descartes 1.11 179.10
TBX20 0.0004516 2446 GTEx DepMap Descartes 0.31 87.48
UNC80 0.0001963 3925 GTEx DepMap Descartes 1.53 47.83
MGAT4C 0.0001883 4001 GTEx DepMap Descartes 1.57 25.75
PNMT 0.0001737 4112 GTEx DepMap Descartes 0.01 5.87
SORCS3 0.0001149 4635 GTEx DepMap Descartes 0.39 29.00
SLC18A1 0.0000953 4863 GTEx DepMap Descartes 0.13 20.09
LAMA3 -0.0001516 11762 GTEx DepMap Descartes 0.48 21.98
GRM7 -0.0002027 12674 GTEx DepMap Descartes 2.04 236.55
CNTNAP5 -0.0002078 12749 GTEx DepMap Descartes 0.90 72.81
CDH18 -0.0002298 13097 GTEx DepMap Descartes 1.22 106.58
GCH1 -0.0003013 14043 GTEx DepMap Descartes 0.48 74.30
NTNG1 -0.0003025 14059 GTEx DepMap Descartes 2.18 223.11
CNTN3 -0.0003902 15061 GTEx DepMap Descartes 0.13 9.43
FGF14 -0.0004110 15291 GTEx DepMap Descartes 11.52 407.68
ST18 -0.0004977 16106 GTEx DepMap Descartes 0.07 4.43
DGKK -0.0005020 16134 GTEx DepMap Descartes 0.08 4.23
SCG2 -0.0005272 16357 GTEx DepMap Descartes 4.39 572.29


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13211.7
Median rank of genes in gene set: 13717.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CAT 0.0003132 3149 GTEx DepMap Descartes 0.30 58.08
HBB 0.0003079 3174 GTEx DepMap Descartes 0.25 204.62
FECH 0.0002623 3437 GTEx DepMap Descartes 0.21 12.12
GYPC 0.0002594 3458 GTEx DepMap Descartes 0.08 19.80
HBA2 0.0001244 4543 GTEx DepMap Descartes 0.07 60.86
HBA1 0.0000930 4900 GTEx DepMap Descartes 0.03 29.01
RHD 0.0000924 4909 GTEx DepMap Descartes 0.08 12.72
HBG1 0.0000183 6049 GTEx DepMap Descartes 0.00 0.00
HBG2 0.0000000 6896 GTEx DepMap Descartes 0.00 0.00
GYPB -0.0000264 8212 GTEx DepMap Descartes 0.02 14.14
ALAS2 -0.0001120 10922 GTEx DepMap Descartes 0.00 0.61
HEMGN -0.0001313 11352 GTEx DepMap Descartes 0.00 0.56
HBZ -0.0001324 11375 GTEx DepMap Descartes 0.00 2.58
EPB42 -0.0001335 11399 GTEx DepMap Descartes 0.00 0.27
HBM -0.0001370 11479 GTEx DepMap Descartes 0.00 3.38
AHSP -0.0001435 11604 GTEx DepMap Descartes 0.00 0.55
GYPA -0.0001450 11633 GTEx DepMap Descartes 0.01 1.34
SELENBP1 -0.0001471 11675 GTEx DepMap Descartes 0.01 1.27
RHCE -0.0001630 11973 GTEx DepMap Descartes 0.04 9.76
CPOX -0.0001941 12522 GTEx DepMap Descartes 0.03 4.61
SPTB -0.0002243 13022 GTEx DepMap Descartes 0.17 5.88
RHAG -0.0002360 13184 GTEx DepMap Descartes 0.00 0.72
SPTA1 -0.0002656 13605 GTEx DepMap Descartes 0.00 0.10
TMCC2 -0.0002833 13830 GTEx DepMap Descartes 0.09 9.30
SLC4A1 -0.0002932 13949 GTEx DepMap Descartes 0.01 0.58
GYPE -0.0003313 14427 GTEx DepMap Descartes 0.04 9.66
CR1L -0.0003795 14949 GTEx DepMap Descartes 0.02 5.26
TSPAN5 -0.0003829 14980 GTEx DepMap Descartes 1.63 193.13
ABCB10 -0.0004010 15168 GTEx DepMap Descartes 0.24 27.77
XPO7 -0.0004959 16092 GTEx DepMap Descartes 0.72 67.18


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 14396.04
Median rank of genes in gene set: 16255
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
HLA-DPA1 0.0004545 2424 GTEx DepMap Descartes 0.21 19.01
SPP1 0.0004106 2613 GTEx DepMap Descartes 1.06 261.88
RBPJ 0.0003094 3168 GTEx DepMap Descartes 1.52 127.84
C1QC 0.0001540 4279 GTEx DepMap Descartes 0.07 28.42
C1QB 0.0001507 4310 GTEx DepMap Descartes 0.11 45.05
CTSC 0.0000229 5937 GTEx DepMap Descartes 0.33 26.92
C1QA -0.0000032 7200 GTEx DepMap Descartes 0.11 48.04
MS4A7 -0.0000377 8682 GTEx DepMap Descartes 0.01 1.87
CTSD -0.0000491 9107 GTEx DepMap Descartes 0.00 0.01
CD14 -0.0000696 9794 GTEx DepMap Descartes 0.08 19.84
CYBB -0.0000768 9993 GTEx DepMap Descartes 0.01 0.62
FGL2 -0.0001074 10812 GTEx DepMap Descartes 0.06 6.06
HLA-DRA -0.0001196 11095 GTEx DepMap Descartes 0.29 105.29
MPEG1 -0.0001301 11325 GTEx DepMap Descartes 0.03 3.39
RNASE1 -0.0001596 11906 GTEx DepMap Descartes 0.07 28.38
CD74 -0.0001765 12214 GTEx DepMap Descartes 0.59 90.11
LGMN -0.0002527 13421 GTEx DepMap Descartes 0.26 54.74
VSIG4 -0.0002858 13871 GTEx DepMap Descartes 0.01 2.14
IFNGR1 -0.0004127 15305 GTEx DepMap Descartes 0.25 42.99
MS4A6A -0.0004217 15412 GTEx DepMap Descartes 0.09 16.74
CPVL -0.0004276 15472 GTEx DepMap Descartes 0.22 39.94
FGD2 -0.0004329 15511 GTEx DepMap Descartes 0.03 2.30
MS4A4A -0.0004724 15881 GTEx DepMap Descartes 0.06 15.23
HLA-DRB1 -0.0005101 16212 GTEx DepMap Descartes 0.06 20.12
TGFBI -0.0005150 16255 GTEx DepMap Descartes 0.18 14.39
HRH1 -0.0005502 16511 GTEx DepMap Descartes 0.23 14.68
CSF1R -0.0005650 16631 GTEx DepMap Descartes 0.06 6.23
CD163 -0.0005784 16743 GTEx DepMap Descartes 0.04 3.32
SLC1A3 -0.0006716 17418 GTEx DepMap Descartes 0.20 18.13
MS4A4E -0.0006889 17531 GTEx DepMap Descartes 0.05 8.66


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 14344.71
Median rank of genes in gene set: 17142
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MARCKS 0.0041567 125 GTEx DepMap Descartes 2.09 279.84
VIM 0.0021859 341 GTEx DepMap Descartes 2.10 383.15
GFRA3 0.0012971 768 GTEx DepMap Descartes 0.18 51.19
SFRP1 0.0008329 1356 GTEx DepMap Descartes 0.49 45.63
SLC35F1 0.0005241 2124 GTEx DepMap Descartes 1.22 121.65
MDGA2 0.0003438 2976 GTEx DepMap Descartes 0.96 46.33
PTN 0.0001540 4278 GTEx DepMap Descartes 0.48 123.83
SOX5 0.0001478 4336 GTEx DepMap Descartes 3.41 238.68
KCTD12 0.0001464 4350 GTEx DepMap Descartes 0.22 15.18
LRRTM4 0.0000322 5758 GTEx DepMap Descartes 2.98 303.20
PAG1 -0.0001223 11153 GTEx DepMap Descartes 0.98 42.42
HMGA2 -0.0001615 11943 GTEx DepMap Descartes 0.04 2.10
ADAMTS5 -0.0001960 12553 GTEx DepMap Descartes 0.08 3.15
FIGN -0.0002282 13073 GTEx DepMap Descartes 0.64 31.61
IL1RAPL1 -0.0002646 13587 GTEx DepMap Descartes 1.19 118.36
NRXN1 -0.0002709 13675 GTEx DepMap Descartes 9.64 452.83
MPZ -0.0003702 14852 GTEx DepMap Descartes 0.05 7.33
SOX10 -0.0003920 15077 GTEx DepMap Descartes 0.05 6.25
ERBB3 -0.0004299 15489 GTEx DepMap Descartes 0.02 1.30
VCAN -0.0004436 15608 GTEx DepMap Descartes 1.38 50.23
OLFML2A -0.0005367 16425 GTEx DepMap Descartes 0.06 3.07
PLP1 -0.0006030 16928 GTEx DepMap Descartes 0.05 4.75
XKR4 -0.0006202 17055 GTEx DepMap Descartes 0.63 11.12
PTPRZ1 -0.0006290 17114 GTEx DepMap Descartes 0.09 3.53
LAMB1 -0.0006330 17142 GTEx DepMap Descartes 1.04 82.64
SCN7A -0.0006415 17211 GTEx DepMap Descartes 0.58 24.62
IL1RAPL2 -0.0006687 17395 GTEx DepMap Descartes 0.52 75.95
COL25A1 -0.0006720 17424 GTEx DepMap Descartes 0.17 9.79
EDNRB -0.0006771 17457 GTEx DepMap Descartes 0.07 5.95
SORCS1 -0.0006792 17476 GTEx DepMap Descartes 1.76 87.94


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 14982.8
Median rank of genes in gene set: 16305
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ACTB 0.0044160 115 GTEx DepMap Descartes 5.51 1380.08
TMSB4X 0.0038437 138 GTEx DepMap Descartes 4.48 1383.48
PRKAR2B 0.0000258 5877 GTEx DepMap Descartes 1.21 125.09
GP9 0.0000147 6124 GTEx DepMap Descartes 0.00 0.04
TUBB1 0.0000147 6127 GTEx DepMap Descartes 0.01 0.91
PPBP -0.0000344 8543 GTEx DepMap Descartes 0.00 0.55
SPN -0.0000633 9589 GTEx DepMap Descartes 0.00 0.00
PF4 -0.0000817 10128 GTEx DepMap Descartes 0.00 0.54
DOK6 -0.0000972 10556 GTEx DepMap Descartes 1.15 55.87
GP1BA -0.0001002 10630 GTEx DepMap Descartes 0.01 1.41
ITGB3 -0.0001009 10646 GTEx DepMap Descartes 0.00 0.01
MED12L -0.0002336 13151 GTEx DepMap Descartes 0.67 27.87
ANGPT1 -0.0003047 14099 GTEx DepMap Descartes 0.17 15.65
RAB27B -0.0003433 14560 GTEx DepMap Descartes 0.27 15.03
P2RX1 -0.0003675 14827 GTEx DepMap Descartes 0.01 0.94
MMRN1 -0.0003784 14934 GTEx DepMap Descartes 0.08 5.51
BIN2 -0.0003947 15115 GTEx DepMap Descartes 0.03 6.60
CD84 -0.0004274 15470 GTEx DepMap Descartes 0.03 2.17
STOM -0.0004610 15775 GTEx DepMap Descartes 0.34 41.97
PDE3A -0.0004670 15818 GTEx DepMap Descartes 2.11 109.96
FLNA -0.0004764 15911 GTEx DepMap Descartes 0.40 20.71
PLEK -0.0004977 16105 GTEx DepMap Descartes 0.03 4.47
PSTPIP2 -0.0005064 16180 GTEx DepMap Descartes 0.07 9.54
ITGA2B -0.0005151 16256 GTEx DepMap Descartes 0.07 7.84
FERMT3 -0.0005206 16305 GTEx DepMap Descartes 0.04 7.44
TGFB1 -0.0005318 16389 GTEx DepMap Descartes 0.28 41.60
SLC2A3 -0.0005637 16614 GTEx DepMap Descartes 0.43 35.87
STON2 -0.0005686 16658 GTEx DepMap Descartes 0.20 19.63
MYLK -0.0005915 16845 GTEx DepMap Descartes 0.30 10.89
TLN1 -0.0005958 16878 GTEx DepMap Descartes 0.34 15.70


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15163.72
Median rank of genes in gene set: 17490
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TMSB10 0.0080109 78 GTEx DepMap Descartes 8.53 10924.99
HLA-C 0.0007423 1544 GTEx DepMap Descartes 0.31 65.13
FOXP1 0.0005002 2237 GTEx DepMap Descartes 0.30 16.87
HLA-A 0.0001740 4108 GTEx DepMap Descartes 0.65 45.89
TOX 0.0001682 4164 GTEx DepMap Descartes 2.48 333.70
GNG2 0.0001154 4628 GTEx DepMap Descartes 1.16 128.45
SCML4 -0.0000110 7531 GTEx DepMap Descartes 0.50 56.08
NKG7 -0.0000870 10262 GTEx DepMap Descartes 0.01 4.75
EVL -0.0000995 10615 GTEx DepMap Descartes 2.22 287.43
ARHGDIB -0.0001086 10842 GTEx DepMap Descartes 0.08 35.32
BCL2 -0.0001239 11206 GTEx DepMap Descartes 4.86 281.69
LEF1 -0.0001404 11540 GTEx DepMap Descartes 0.33 36.36
HLA-B -0.0002009 12652 GTEx DepMap Descartes 0.35 94.08
SORL1 -0.0002165 12898 GTEx DepMap Descartes 0.58 24.61
PDE3B -0.0003356 14473 GTEx DepMap Descartes 1.54 116.88
CD44 -0.0003483 14613 GTEx DepMap Descartes 1.50 124.62
B2M -0.0003670 14821 GTEx DepMap Descartes 3.71 627.56
ETS1 -0.0003788 14938 GTEx DepMap Descartes 0.34 30.99
CCL5 -0.0003898 15054 GTEx DepMap Descartes 0.02 8.72
ITPKB -0.0005448 16478 GTEx DepMap Descartes 0.16 11.41
LCP1 -0.0006285 17111 GTEx DepMap Descartes 0.12 13.88
RCSD1 -0.0006302 17121 GTEx DepMap Descartes 0.11 10.28
BACH2 -0.0006684 17392 GTEx DepMap Descartes 2.00 94.08
IFI16 -0.0006814 17490 GTEx DepMap Descartes 0.35 33.65
IKZF1 -0.0008223 18265 GTEx DepMap Descartes 0.14 12.30
SKAP1 -0.0008410 18367 GTEx DepMap Descartes 0.24 75.28
CCND3 -0.0008512 18433 GTEx DepMap Descartes 0.51 91.48
STK39 -0.0008545 18443 GTEx DepMap Descartes 1.43 194.07
SAMD3 -0.0009332 18775 GTEx DepMap Descartes 0.50 73.12
MCTP2 -0.0009433 18812 GTEx DepMap Descartes 0.22 10.64


Embryonic Pausing Signatures Up
Embryonic pausing signature upregulated genes from Supplementary Table 6 of Rehman et al. Cell 2021. These genes are upregulated in paused ESCs and diapaused embryos.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.65e-01
Mean rank of genes in gene set: 8759.43
Median rank of genes in gene set: 7236.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
DPP7 0.0009047 1230 GTEx DepMap Descartes 0.44 121.38
CCNG2 0.0005631 2001 GTEx DepMap Descartes 0.34 31.50
APOE 0.0002212 3725 GTEx DepMap Descartes 1.10 355.78
PDCD4 0.0001318 4479 GTEx DepMap Descartes 0.59 75.23
HEXA 0.0001104 4687 GTEx DepMap Descartes 0.04 2.41
ALDH6A1 0.0000435 5556 GTEx DepMap Descartes 0.10 8.59
LY6G6E 0.0000000 6989 GTEx DepMap Descartes 0.00 0.00
SPRY1 -0.0000101 7484 GTEx DepMap Descartes 0.26 37.89
RENBP -0.0000422 8849 GTEx DepMap Descartes 0.07 20.31
CTSL -0.0000814 10120 GTEx DepMap Descartes 0.38 NA
HEXB -0.0003026 14061 GTEx DepMap Descartes 0.22 45.47
ACSS1 -0.0005811 16761 GTEx DepMap Descartes 0.05 3.59
YPEL2 -0.0006298 17119 GTEx DepMap Descartes 0.55 37.97
AUH -0.0011716 19571 GTEx DepMap Descartes 0.98 250.97


Embryonic Pausing Signatures Down
Embryonic pausing signature downregulated genes from Supplementary Table 6 of Rehman et al. Cell 2021. These genes are downregulated in paused ESCs and diapaused embryos.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.33e-26
Mean rank of genes in gene set: 4155.57
Median rank of genes in gene set: 1744
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
RPL41 0.0122859 40 GTEx DepMap Descartes 6.27 5388.55
RANBP1 0.0032601 172 GTEx DepMap Descartes 0.74 211.20
HSPE1 0.0032458 174 GTEx DepMap Descartes 0.86 594.01
PPA1 0.0031751 184 GTEx DepMap Descartes 1.34 197.34
SNRPE 0.0031569 189 GTEx DepMap Descartes 0.61 229.30
SNRPD2 0.0031318 190 GTEx DepMap Descartes 0.65 419.38
SLC25A5 0.0031148 192 GTEx DepMap Descartes 0.40 153.96
RAN 0.0030176 202 GTEx DepMap Descartes 1.43 327.24
HMGA1 0.0028512 222 GTEx DepMap Descartes 0.42 122.03
MDH2 0.0026951 246 GTEx DepMap Descartes 0.65 161.41
POLR2I 0.0024567 282 GTEx DepMap Descartes 0.40 213.81
TMEM258 0.0021373 356 GTEx DepMap Descartes 0.72 NA
PHB 0.0020733 378 GTEx DepMap Descartes 0.67 173.18
RPS27L 0.0020730 379 GTEx DepMap Descartes 0.53 42.58
PA2G4 0.0019946 395 GTEx DepMap Descartes 0.43 105.72
PEBP1 0.0019548 402 GTEx DepMap Descartes 2.56 756.75
UQCR10 0.0019387 408 GTEx DepMap Descartes 0.85 480.63
UQCRQ 0.0019377 409 GTEx DepMap Descartes 0.70 233.95
PDCD5 0.0019001 421 GTEx DepMap Descartes 0.55 148.63
TMEM97 0.0018761 437 GTEx DepMap Descartes 0.25 55.96
PRDX2 0.0017685 485 GTEx DepMap Descartes 0.26 75.81
RPS19BP1 0.0017134 505 GTEx DepMap Descartes 0.40 69.28
NDUFS8 0.0016119 556 GTEx DepMap Descartes 0.49 77.58
DCTPP1 0.0015876 566 GTEx DepMap Descartes 0.16 74.77
NDUFC1 0.0015603 583 GTEx DepMap Descartes 0.41 152.20
POLR2L 0.0015596 586 GTEx DepMap Descartes 0.40 215.04
ELOF1 0.0014486 642 GTEx DepMap Descartes 0.16 38.49
CCDC28B 0.0014270 655 GTEx DepMap Descartes 0.15 63.35
SAC3D1 0.0014246 658 GTEx DepMap Descartes 0.22 67.29
PHGDH 0.0014161 664 GTEx DepMap Descartes 0.22 41.74


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Cycling cells: Cycling T cells (curated markers)
proliferating T lymphocytes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 4.41e-03
Mean rank of genes in gene set: 1307
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
TOP2A 0.0010713 989 GTEx DepMap Descartes 0.79 88.56
CD3D 0.0008723 1287 GTEx DepMap Descartes 0.03 23.95
MKI67 0.0006942 1645 GTEx DepMap Descartes 0.28 14.02


T cells: CD8a/b(entry) (model markers)
T lymphocytes with CD8 alpha/beta heterodimers in the late double-positive (entry) stage during T cell development:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.03e-02
Mean rank of genes in gene set: 5705.56
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RPL10 0.0153615 4 GTEx DepMap Descartes 10.55 2725.06
RPS27 0.0144188 10 GTEx DepMap Descartes 6.70 6659.67
TMSB10 0.0080109 78 GTEx DepMap Descartes 8.53 10924.99
FTL 0.0009297 1188 GTEx DepMap Descartes 4.37 2343.26
MT-ND2 0.0002003 3902 GTEx DepMap Descartes 8.03 3170.55
ITM2A 0.0001411 4394 GTEx DepMap Descartes 0.04 10.33
SATB1 -0.0001020 10679 GTEx DepMap Descartes 0.01 0.47
CD44 -0.0003483 14613 GTEx DepMap Descartes 1.50 124.62
CD1E -0.0005451 16482 GTEx DepMap Descartes 0.01 0.79


HSC/MPP: Early lymphoid/T lymphoid (model markers)
early lymphoid/T lymphocytes with lymphocyte potential in the fetal liver before T cells emerged from the thymus:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.64e-02
Mean rank of genes in gene set: 6235.38
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
RACK1 0.0123656 39 GTEx DepMap Descartes 4.71 NA
ATP5F1E 0.0048155 104 GTEx DepMap Descartes 2.90 NA
HBA2 0.0001244 4543 GTEx DepMap Descartes 0.07 60.86
HBA1 0.0000930 4900 GTEx DepMap Descartes 0.03 29.01
HBG2 0.0000000 6896 GTEx DepMap Descartes 0.00 0.00
IGHV5-78 -0.0000245 8126 GTEx DepMap Descartes 0.00 0.00
SOST -0.0000511 9169 GTEx DepMap Descartes 0.00 0.05
ST18 -0.0004977 16106 GTEx DepMap Descartes 0.07 4.43