Program: 29. Cancer-Associated Fibroblasts.

Program: 29. Cancer-Associated Fibroblasts.


Program description and justification of annotation generated by GPT5: Cancer-Associated Fibroblasts (CAF) - myofibroblastic ECM remodeling with TGF-beta/iCAF features; stromal/perivascular continuum.

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QQ-plot of gene loadings, averaged over both independent splits of the data
 This plot highlights the relative contribution of each gene to the GEP

Interactive QQ Plot

Top genes driving this program.
 Note: Decartes website is buggy, try refreshing. Also, Decartes fetal adrenal data have been collected at specific time points (89-122 days), all possible cell types of interest may not be represented, do not overinterpret.
The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.

Gene Loading Gene.Name GTEx DepMap Descartes Mean.Counts Mean.Tpm
1 COL3A1 0.0091022 collagen type III alpha 1 chain GTEx DepMap Descartes 22.70 2636.24
2 COL1A2 0.0090765 collagen type I alpha 2 chain GTEx DepMap Descartes 25.13 2704.87
3 COL1A1 0.0089022 collagen type I alpha 1 chain GTEx DepMap Descartes 26.11 2919.87
4 SFRP4 0.0079158 secreted frizzled related protein 4 GTEx DepMap Descartes 1.85 335.96
5 LUM 0.0079013 lumican GTEx DepMap Descartes 3.34 760.33
6 MGP 0.0076330 matrix Gla protein GTEx DepMap Descartes 9.18 3183.28
7 SPARC 0.0073831 secreted protein acidic and cysteine rich GTEx DepMap Descartes 9.06 1554.29
8 THBS2 0.0063489 thrombospondin 2 GTEx DepMap Descartes 4.80 493.88
9 SFRP2 0.0059625 secreted frizzled related protein 2 GTEx DepMap Descartes 1.48 455.13
10 DCN 0.0057837 decorin GTEx DepMap Descartes 3.84 333.99
11 IGFBP5 0.0055329 insulin like growth factor binding protein 5 GTEx DepMap Descartes 5.40 464.83
12 POSTN 0.0053938 periostin GTEx DepMap Descartes 5.02 937.88
13 TIMP1 0.0052738 TIMP metallopeptidase inhibitor 1 GTEx DepMap Descartes 4.82 2591.36
14 BGN 0.0051920 biglycan GTEx DepMap Descartes 2.39 648.30
15 CCDC80 0.0051759 coiled-coil domain containing 80 GTEx DepMap Descartes 2.32 114.52
16 AEBP1 0.0049027 AE binding protein 1 GTEx DepMap Descartes 2.41 382.98
17 COL10A1 0.0048890 collagen type X alpha 1 chain GTEx DepMap Descartes 0.60 97.47
18 IGFBP7 0.0047647 insulin like growth factor binding protein 7 GTEx DepMap Descartes 19.11 7926.95
19 VCAN 0.0047246 versican GTEx DepMap Descartes 7.91 358.23
20 CTHRC1 0.0045763 collagen triple helix repeat containing 1 GTEx DepMap Descartes 0.99 462.15
21 LOX 0.0045611 lysyl oxidase GTEx DepMap Descartes 0.39 45.05
22 FBLN2 0.0044416 fibulin 2 GTEx DepMap Descartes 0.80 113.59
23 COL5A1 0.0044354 collagen type V alpha 1 chain GTEx DepMap Descartes 4.10 307.10
24 ITGBL1 0.0043320 integrin subunit beta like 1 GTEx DepMap Descartes 2.82 330.12
25 LAMP5 0.0043281 lysosomal associated membrane protein family member 5 GTEx DepMap Descartes 0.32 99.22
26 ISLR 0.0042190 immunoglobulin superfamily containing leucine rich repeat GTEx DepMap Descartes 0.48 125.10
27 COMP 0.0041548 cartilage oligomeric matrix protein GTEx DepMap Descartes 0.27 63.35
28 LTBP2 0.0040403 latent transforming growth factor beta binding protein 2 GTEx DepMap Descartes 1.51 114.21
29 PRSS23 0.0039537 serine protease 23 GTEx DepMap Descartes 2.94 315.18
30 COL6A3 0.0038533 collagen type VI alpha 3 chain GTEx DepMap Descartes 6.38 385.35
31 FNDC1 0.0037311 fibronectin type III domain containing 1 GTEx DepMap Descartes 0.84 81.35
32 C1R 0.0036704 complement C1r GTEx DepMap Descartes 1.10 194.74
33 PRELP 0.0034662 proline and arginine rich end leucine rich repeat protein GTEx DepMap Descartes 0.48 51.27
34 FBN1 0.0034442 fibrillin 1 GTEx DepMap Descartes 3.67 183.67
35 SULF1 0.0034207 sulfatase 1 GTEx DepMap Descartes 9.02 933.45
36 INHBA 0.0033887 inhibin subunit beta A GTEx DepMap Descartes 1.80 170.81
37 FSTL1 0.0033109 follistatin like 1 GTEx DepMap Descartes 2.43 245.20
38 COL6A2 0.0032523 collagen type VI alpha 2 chain GTEx DepMap Descartes 3.53 647.18
39 TMEM119 0.0032448 transmembrane protein 119 GTEx DepMap Descartes 0.28 61.50
40 F2R 0.0031486 coagulation factor II thrombin receptor GTEx DepMap Descartes 1.07 164.79
41 COL6A1 0.0030892 collagen type VI alpha 1 chain GTEx DepMap Descartes 2.51 378.26
42 IGFBP4 0.0030373 insulin like growth factor binding protein 4 GTEx DepMap Descartes 2.09 536.09
43 FAP 0.0030129 fibroblast activation protein alpha GTEx DepMap Descartes 2.08 439.00
44 FN1 0.0029355 fibronectin 1 GTEx DepMap Descartes 11.91 778.73
45 COL14A1 0.0029033 collagen type XIV alpha 1 chain GTEx DepMap Descartes 3.23 243.58
46 LRRC32 0.0028550 leucine rich repeat containing 32 GTEx DepMap Descartes 0.65 88.33
47 CCN2 0.0028457 cellular communication network factor 2 GTEx DepMap Descartes 3.80 NA
48 FMO2 0.0027749 flavin containing dimethylaniline monoxygenase 2 GTEx DepMap Descartes 0.74 77.44
49 S100A11 0.0027685 S100 calcium binding protein A11 GTEx DepMap Descartes 0.95 906.99
50 CDH11 0.0027664 cadherin 11 GTEx DepMap Descartes 4.77 393.24


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UMAP plots showing activity of gene expression program identified in GEP 29. Cancer-Associated Fibroblasts:

Interactive UMAP Plot
Interactive UMAP Plot

Boxlot showing activity of gene expression program identified in GEP 29. Cancer-Associated Fibroblasts:
Interactive Boxplot
Interactive Boxplot

Gene set Enrichments for this program, caculated from top 50 genes


mSigDB Cell Types Gene Set:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
DESCARTES_FETAL_EYE_STROMAL_CELLS 8.33e-45 284.52 148.94 2.80e-42 5.59e-42
24COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, SFRP2, DCN, POSTN, CTHRC1, LOX, COL5A1, ITGBL1, ISLR, COL6A3, FNDC1, C1R, FBN1, INHBA, COL6A2, COL6A1, FN1, COL14A1
 90
DURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_FIBROBLASTS_STROMAL_CELLS 6.86e-34 198.90 100.83 5.12e-32 4.61e-31
19COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, SFRP2, DCN, IGFBP5, POSTN, TIMP1, BGN, AEBP1, IGFBP7, ITGBL1, C1R, COL6A2, IGFBP4, CDH11
 82
DESCARTES_FETAL_THYMUS_STROMAL_CELLS 3.51e-42 182.13 97.22 5.88e-40 2.35e-39
25COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, SFRP2, DCN, IGFBP5, POSTN, TIMP1, BGN, CCDC80, VCAN, LOX, FBLN2, COL5A1, ISLR, FNDC1, C1R, FBN1, FSTL1, COL6A1, COL14A1
 137
CUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL 3.40e-37 169.50 88.79 4.56e-35 2.28e-34
22COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, DCN, TIMP1, IGFBP7, LOX, FBLN2, COL5A1, ISLR, COL6A3, FNDC1, C1R, FBN1, FSTL1, COL6A2, COL6A1, COL14A1, CCN2
 117
AIZARANI_LIVER_C21_STELLATE_CELLS_1 2.15e-42 144.03 77.74 4.82e-40 1.44e-39
27COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, DCN, IGFBP5, TIMP1, BGN, CCDC80, AEBP1, IGFBP7, FBLN2, COL5A1, PRSS23, COL6A3, C1R, PRELP, FBN1, FSTL1, COL6A2, COL6A1, IGFBP4, COL14A1, CCN2
 194
CUI_DEVELOPING_HEART_COMPACT_VENTRICULAR_CARDIOMYOCYTE 1.80e-24 155.30 73.20 7.09e-23 1.21e-21
14COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, DCN, POSTN, COL5A1, COL6A3, FBN1, COL6A2, COL6A1, FN1
 65
GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR 5.41e-30 142.62 72.10 2.79e-28 3.63e-27
18COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, SFRP2, DCN, CCDC80, VCAN, CTHRC1, LOX, COL5A1, ISLR, FNDC1, C1R, COL14A1
 99
CUI_DEVELOPING_HEART_SMOOTH_MUSCLE_CELL 1.10e-19 155.67 66.81 3.88e-18 7.36e-17
11COL3A1, COL1A2, COL1A1, SPARC, SFRP2, BGN, CCDC80, LOX, C1R, IGFBP4, COL14A1
 48
MURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL 4.47e-49 113.54 56.86 3.00e-46 3.00e-46
39COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, SFRP2, DCN, IGFBP5, POSTN, TIMP1, BGN, CCDC80, AEBP1, IGFBP7, VCAN, CTHRC1, LOX, COL5A1, LAMP5, ISLR, LTBP2, COL6A3, C1R, FBN1, SULF1, INHBA, FSTL1, COL6A2, F2R, COL6A1, IGFBP4, FAP, FN1, LRRC32, CCN2, S100A11, CDH11
 680
DESCARTES_FETAL_KIDNEY_STROMAL_CELLS 9.20e-31 108.44 56.73 5.61e-29 6.17e-28
20COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, THBS2, SFRP2, DCN, POSTN, LOX, FBLN2, ISLR, LTBP2, FNDC1, C1R, PRELP, FBN1, SULF1, COL14A1
 146
DESCARTES_FETAL_ADRENAL_STROMAL_CELLS 2.46e-30 102.73 53.77 1.38e-28 1.65e-27
20COL3A1, COL1A1, LUM, MGP, THBS2, SFRP2, DCN, POSTN, CCDC80, LOX, ITGBL1, ISLR, COL6A3, FNDC1, C1R, PRELP, SULF1, TMEM119, FAP, CDH11
 153
RUBENSTEIN_SKELETAL_MUSCLE_FAP_CELLS 7.19e-31 94.10 49.77 4.82e-29 4.82e-28
21COL3A1, COL1A2, COL1A1, SFRP4, LUM, MGP, DCN, TIMP1, CCDC80, IGFBP7, VCAN, FBLN2, ISLR, COL6A3, C1R, FSTL1, COL6A2, COL6A1, FN1, FMO2, S100A11
 179
DESCARTES_MAIN_FETAL_STROMAL_CELLS 1.03e-09 152.05 41.27 2.04e-08 6.93e-07
5COL1A2, COL1A1, THBS2, COL5A1, ITGBL1
 20
HU_FETAL_RETINA_FIBROBLAST 5.60e-36 73.16 39.95 5.37e-34 3.76e-33
28COL3A1, COL1A2, COL1A1, LUM, SPARC, DCN, IGFBP5, TIMP1, BGN, CCDC80, AEBP1, IGFBP7, VCAN, COL5A1, PRSS23, COL6A3, C1R, FBN1, SULF1, FSTL1, COL6A2, TMEM119, F2R, IGFBP4, FN1, CCN2, S100A11, CDH11
 385
MENON_FETAL_KIDNEY_3_STROMAL_CELLS 5.46e-17 82.56 36.62 1.83e-15 3.67e-14
11COL3A1, COL1A2, COL1A1, SPARC, IGFBP5, POSTN, VCAN, COL6A3, FSTL1, FN1, CDH11
 81
TRAVAGLINI_LUNG_MYOFIBROBLAST_CELL 3.86e-14 80.27 32.75 1.08e-12 2.59e-11
9COL3A1, COL1A1, POSTN, VCAN, CTHRC1, COMP, LTBP2, PRELP, CCN2
 65
GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS 1.89e-34 59.50 32.57 1.58e-32 1.27e-31
29COL3A1, COL1A2, COL1A1, LUM, MGP, SPARC, DCN, IGFBP5, POSTN, BGN, CCDC80, AEBP1, IGFBP7, VCAN, LOX, COL5A1, ISLR, LTBP2, COL6A3, C1R, FBN1, SULF1, FSTL1, COL6A2, TMEM119, COL6A1, COL14A1, LRRC32, CDH11
 505
DESCARTES_FETAL_HEART_STROMAL_CELLS 1.90e-10 99.95 32.15 3.87e-09 1.28e-07
6COL1A2, COL1A1, LUM, DCN, ISLR, PRELP
 34
FAN_OVARY_CL6_PUTATIVE_EARLY_ATRETIC_FOLLICLE_THECAL_CELL_2 8.21e-28 58.01 31.23 3.93e-26 5.51e-25
22COL3A1, COL1A2, COL1A1, SFRP4, LUM, MGP, SPARC, DCN, IGFBP5, TIMP1, BGN, CCDC80, AEBP1, COL6A3, C1R, PRELP, FSTL1, COL6A2, COL6A1, IGFBP4, FN1, CDH11
 300
DESCARTES_FETAL_MUSCLE_STROMAL_CELLS 4.86e-16 66.47 29.69 1.55e-14 3.26e-13
11COL3A1, COL1A2, COL1A1, LUM, MGP, DCN, POSTN, ISLR, FNDC1, C1R, TMEM119
 98

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mSigDB Hallmark Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 3.54e-44 151.48 81.77 1.77e-42 1.77e-42
28COL3A1, COL1A2, COL1A1, SFRP4, LUM, MGP, SPARC, THBS2, DCN, POSTN, TIMP1, BGN, VCAN, CTHRC1, LOX, FBLN2, COL5A1, COMP, COL6A3, FBN1, INHBA, FSTL1, COL6A2, IGFBP4, FAP, FN1, CCN2, CDH11
 200
HALLMARK_ANGIOGENESIS 2.74e-10 93.13 30.16 6.86e-09 1.37e-08
6COL3A1, LUM, POSTN, TIMP1, VCAN, FSTL1
 36
HALLMARK_COAGULATION 3.92e-08 25.49 9.50 6.53e-07 1.96e-06
7SPARC, TIMP1, COMP, PRSS23, C1R, FBN1, FN1
 138
HALLMARK_MYOGENESIS 4.84e-07 17.32 6.49 6.05e-06 2.42e-05
7COL3A1, COL1A1, SPARC, AEBP1, IGFBP7, COL6A3, COL6A2
 200
HALLMARK_APOPTOSIS 4.23e-05 14.62 4.47 4.23e-04 2.11e-03
5LUM, DCN, TIMP1, BGN, F2R
 161
HALLMARK_HYPOXIA 1.17e-04 11.70 3.59 9.74e-04 5.85e-03
5DCN, BGN, LOX, COL5A1, CCN2
 200
HALLMARK_UV_RESPONSE_DN 4.01e-04 12.75 3.29 2.87e-03 2.01e-02
4COL3A1, COL1A2, COL1A1, IGFBP5
 144
HALLMARK_APICAL_JUNCTION 1.23e-02 6.65 1.31 5.61e-02 6.17e-01
3VCAN, FBN1, CDH11
 200
HALLMARK_COMPLEMENT 1.23e-02 6.65 1.31 5.61e-02 6.17e-01
3TIMP1, C1R, FN1
 200
HALLMARK_GLYCOLYSIS 1.23e-02 6.65 1.31 5.61e-02 6.17e-01
3DCN, VCAN, COL5A1
 200
HALLMARK_ALLOGRAFT_REJECTION 1.23e-02 6.65 1.31 5.61e-02 6.17e-01
3TIMP1, INHBA, F2R
 200
HALLMARK_ESTROGEN_RESPONSE_EARLY 8.36e-02 4.32 0.51 2.79e-01 1.00e+00
2PRSS23, IGFBP4
 200
HALLMARK_ESTROGEN_RESPONSE_LATE 8.36e-02 4.32 0.51 2.79e-01 1.00e+00
2PRSS23, IGFBP4
 200
HALLMARK_INFLAMMATORY_RESPONSE 8.36e-02 4.32 0.51 2.79e-01 1.00e+00
2TIMP1, INHBA
 200
HALLMARK_KRAS_SIGNALING_UP 8.36e-02 4.32 0.51 2.79e-01 1.00e+00
2ITGBL1, INHBA
 200
HALLMARK_TGF_BETA_SIGNALING 1.23e-01 7.91 0.19 3.84e-01 1.00e+00
1LTBP2
 54
HALLMARK_CHOLESTEROL_HOMEOSTASIS 1.64e-01 5.74 0.14 4.84e-01 1.00e+00
1S100A11
 74
HALLMARK_IL2_STAT5_SIGNALING 3.82e-01 2.12 0.05 8.34e-01 1.00e+00
1COL6A1
 199
HALLMARK_TNFA_SIGNALING_VIA_NFKB 3.84e-01 2.11 0.05 8.34e-01 1.00e+00
1INHBA
 200
HALLMARK_INTERFERON_GAMMA_RESPONSE 3.84e-01 2.11 0.05 8.34e-01 1.00e+00
1C1R
 200

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KEGG Pathways:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
KEGG_ECM_RECEPTOR_INTERACTION 6.36e-15 69.25 29.74 1.18e-12 1.18e-12
10COL3A1, COL1A2, COL1A1, THBS2, COL5A1, COMP, COL6A3, COL6A2, COL6A1, FN1
 84
KEGG_FOCAL_ADHESION 3.80e-11 27.14 11.93 3.53e-09 7.07e-09
10COL3A1, COL1A2, COL1A1, THBS2, COL5A1, COMP, COL6A3, COL6A2, COL6A1, FN1
 199
KEGG_TGF_BETA_SIGNALING_PATHWAY 5.56e-05 21.76 5.56 3.44e-03 1.03e-02
4THBS2, DCN, COMP, INHBA
 86
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 1.22e-02 12.76 1.47 5.65e-01 1.00e+00
2C1R, F2R
 69
KEGG_WNT_SIGNALING_PATHWAY 5.14e-02 5.74 0.67 1.00e+00 1.00e+00
2SFRP4, SFRP2
 151
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 9.29e-02 4.06 0.47 1.00e+00 1.00e+00
2F2R, FN1
 213
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 1.60e-01 5.90 0.14 1.00e+00 1.00e+00
1FMO2
 72
KEGG_SMALL_CELL_LUNG_CANCER 1.84e-01 5.05 0.12 1.00e+00 1.00e+00
1FN1
 84
KEGG_CELL_ADHESION_MOLECULES_CAMS 2.76e-01 3.17 0.08 1.00e+00 1.00e+00
1VCAN
 133
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 2.86e-01 3.04 0.07 1.00e+00 1.00e+00
1C1R
 139
KEGG_CALCIUM_SIGNALING_PATHWAY 3.50e-01 2.37 0.06 1.00e+00 1.00e+00
1F2R
 178
KEGG_ENDOCYTOSIS 3.55e-01 2.33 0.06 1.00e+00 1.00e+00
1F2R
 181
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 4.73e-01 1.59 0.04 1.00e+00 1.00e+00
1INHBA
 265
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 4.82e-01 1.55 0.04 1.00e+00 1.00e+00
1F2R
 272
KEGG_PATHWAYS_IN_CANCER 5.43e-01 1.29 0.03 1.00e+00 1.00e+00
1FN1
 325
KEGG_N_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 46
KEGG_OTHER_GLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 16
KEGG_O_GLYCAN_BIOSYNTHESIS 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 30
KEGG_GLYCOSAMINOGLYCAN_DEGRADATION 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 21
KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.00e+00 0.00 0.00 1.00e+00 1.00e+00
0
 15

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CHR Positional Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
chr2q35 3.72e-02 6.90 0.80 1.00e+00 1.00e+00
2IGFBP5, FN1
 126
chr12q21 3.83e-02 6.79 0.79 1.00e+00 1.00e+00
2LUM, DCN
 128
chr7p14 5.88e-02 5.31 0.62 1.00e+00 1.00e+00
2SFRP4, INHBA
 163
chr3q13 7.46e-02 4.62 0.54 1.00e+00 1.00e+00
2CCDC80, FSTL1
 187
chr21q22 2.06e-01 2.44 0.29 1.00e+00 1.00e+00
2COL6A2, COL6A1
 353
chr17q21 2.96e-01 1.88 0.22 1.00e+00 1.00e+00
2COL1A1, IGFBP4
 457
chr7p13 1.14e-01 8.55 0.21 1.00e+00 1.00e+00
1AEBP1
 50
chr13q33 1.25e-01 7.76 0.19 1.00e+00 1.00e+00
1ITGBL1
 55
chr8q13 1.58e-01 5.99 0.15 1.00e+00 1.00e+00
1SULF1
 71
chr16q21 1.64e-01 5.74 0.14 1.00e+00 1.00e+00
1CDH11
 74
chr6q27 1.66e-01 5.66 0.14 1.00e+00 1.00e+00
1THBS2
 75
chr13q13 1.72e-01 5.44 0.13 1.00e+00 1.00e+00
1POSTN
 78
chr4q12 1.74e-01 5.37 0.13 1.00e+00 1.00e+00
1IGFBP7
 79
chr20p12 2.23e-01 4.07 0.10 1.00e+00 1.00e+00
1LAMP5
 104
chr6q23 2.27e-01 3.99 0.10 1.00e+00 1.00e+00
1CCN2
 106
chr12p12 2.29e-01 3.95 0.10 1.00e+00 1.00e+00
1MGP
 107
chr2q32 2.30e-01 3.92 0.10 1.00e+00 1.00e+00
1COL3A1
 108
chr5q33 2.32e-01 3.88 0.10 1.00e+00 1.00e+00
1SPARC
 109
chr5q23 2.36e-01 3.81 0.09 1.00e+00 1.00e+00
1LOX
 111
chr15q24 2.45e-01 3.64 0.09 1.00e+00 1.00e+00
1ISLR
 116

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Transcription Factor Targets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
MZF1_01 2.29e-05 11.97 4.13 8.64e-03 2.59e-02
6DCN, IGFBP5, PRELP, SULF1, TMEM119, CCN2
 240
AAANWWTGC_UNKNOWN 1.04e-04 12.01 3.68 2.94e-02 1.18e-01
5THBS2, SFRP2, LOX, INHBA, FN1
 195
TGGAAA_NFAT_Q4_01 7.42e-08 6.03 3.18 8.41e-05 8.41e-05
18COL1A2, SFRP4, MGP, DCN, IGFBP5, CCDC80, IGFBP7, VCAN, CTHRC1, LOX, LTBP2, PRELP, SULF1, INHBA, FSTL1, FAP, FN1, CCN2
 1934
TATAAA_TATA_01 5.55e-06 5.53 2.69 3.14e-03 6.29e-03
13COL1A2, COL1A1, MGP, THBS2, POSTN, COL10A1, CTHRC1, LAMP5, SULF1, INHBA, IGFBP4, FN1, CCN2
 1317
TGGNNNNNNKCCAR_UNKNOWN 5.65e-04 6.51 2.26 1.07e-01 6.40e-01
6SFRP2, IGFBP5, CTHRC1, LOX, COL6A3, FAP
 436
AGCYRWTTC_UNKNOWN 3.12e-03 11.11 2.18 4.32e-01 1.00e+00
3LAMP5, FSTL1, FAP
 121
AP3_Q6 3.07e-03 7.23 1.88 4.32e-01 1.00e+00
4SPARC, SULF1, FSTL1, FN1
 251
AACTTT_UNKNOWN 2.22e-04 3.77 1.84 5.04e-02 2.52e-01
13COL3A1, COL1A2, LUM, SPARC, DCN, POSTN, CCDC80, VCAN, LOX, ITGBL1, LAMP5, INHBA, CDH11
 1928
POU3F2_02 3.71e-03 6.84 1.78 4.32e-01 1.00e+00
4SFRP2, DCN, CCDC80, LOX
 265
CEBPB_01 3.81e-03 6.79 1.76 4.32e-01 1.00e+00
4DCN, IGFBP5, SULF1, FAP
 267
MSX1_01 8.63e-03 7.62 1.50 5.86e-01 1.00e+00
3POSTN, COL6A3, INHBA
 175
PIAS4_TARGET_GENES 1.53e-02 11.25 1.30 5.86e-01 1.00e+00
2VCAN, COL6A1
 78
CTTTGA_LEF1_Q2 6.99e-03 3.16 1.28 5.86e-01 1.00e+00
8SFRP2, DCN, BGN, CTHRC1, COL5A1, LAMP5, SULF1, INHBA
 1247
CEBP_C 1.35e-02 6.42 1.27 5.86e-01 1.00e+00
3DCN, FSTL1, CCN2
 207
FOX_Q2 1.46e-02 6.24 1.23 5.86e-01 1.00e+00
3CTHRC1, ITGBL1, FSTL1
 213
GGGTGGRR_PAX4_03 9.14e-03 3.01 1.22 5.86e-01 1.00e+00
8COL1A1, SPARC, DCN, IGFBP5, VCAN, COL6A3, PRELP, TMEM119
 1310
WGGAATGY_TEF1_Q6 1.35e-02 4.66 1.21 5.86e-01 1.00e+00
4SPARC, INHBA, FSTL1, CCN2
 387
TAATTA_CHX10_01 1.19e-02 3.43 1.19 5.86e-01 1.00e+00
6COL1A1, DCN, COL10A1, ITGBL1, SULF1, FAP
 823
TGTYNNNNNRGCARM_UNKNOWN 1.92e-02 9.95 1.15 5.86e-01 1.00e+00
2MGP, SPARC
 88
RYTTCCTG_ETS2_B 1.33e-02 3.03 1.15 5.86e-01 1.00e+00
7SPARC, THBS2, TIMP1, CCDC80, COL6A3, FSTL1, IGFBP4
 1112

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GO Biological Processes:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GOBP_COLLAGEN_FIBRIL_ORGANIZATION 5.90e-17 116.32 48.81 1.47e-13 4.41e-13
10COL3A1, COL1A2, COL1A1, LUM, SFRP2, AEBP1, LOX, COL5A1, COMP, COL14A1
 54
GOBP_EXTERNAL_ENCAPSULATING_STRUCTURE_ORGANIZATION 8.39e-34 65.32 35.72 6.28e-30 6.28e-30
27COL3A1, COL1A2, COL1A1, LUM, SPARC, SFRP2, DCN, POSTN, TIMP1, BGN, CCDC80, AEBP1, COL10A1, VCAN, LOX, FBLN2, COL5A1, COMP, COL6A3, FBN1, SULF1, COL6A2, COL6A1, FAP, FN1, COL14A1, CCN2
 396
GOBP_DERMATAN_SULFATE_METABOLIC_PROCESS 3.78e-06 130.51 22.38 6.56e-04 2.83e-02
3DCN, BGN, VCAN
 13
GOBP_CHONDROITIN_SULFATE_CATABOLIC_PROCESS 4.81e-06 118.70 20.61 7.87e-04 3.60e-02
3DCN, BGN, VCAN
 14
GOBP_PEPTIDE_CROSS_LINKING_VIA_CHONDROITIN_4_SULFATE_GLYCOSAMINOGLYCAN 8.61e-05 211.61 18.81 8.59e-03 6.44e-01
2DCN, BGN
 6
GOBP_NEGATIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY 8.61e-05 211.61 18.81 8.59e-03 6.44e-01
2SFRP4, SFRP2
 6
GOBP_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS 7.37e-06 100.75 17.79 1.03e-03 5.51e-02
3DCN, BGN, VCAN
 16
GOBP_TENDON_DEVELOPMENT 1.20e-04 169.99 15.84 1.11e-02 9.01e-01
2COL5A1, COMP
 7
GOBP_REGULATION_OF_BONE_DEVELOPMENT 1.20e-04 169.99 15.84 1.11e-02 9.01e-01
2LOX, TMEM119
 7
GOBP_SKELETAL_SYSTEM_DEVELOPMENT 8.40e-19 27.02 14.31 3.14e-15 6.29e-15
19COL3A1, COL1A2, COL1A1, SFRP4, LUM, MGP, SFRP2, TIMP1, BGN, COL10A1, VCAN, LOX, COMP, PRELP, FBN1, SULF1, TMEM119, CCN2, CDH11
 485
GOBP_PEPTIDE_CROSS_LINKING 1.51e-06 57.50 14.18 3.54e-04 1.13e-02
4COL3A1, DCN, BGN, FN1
 35
GOBP_WOUND_HEALING_INVOLVED_IN_INFLAMMATORY_RESPONSE 1.60e-04 141.92 13.68 1.38e-02 1.00e+00
2TIMP1, F2R
 8
GOBP_SULFUR_COMPOUND_CATABOLIC_PROCESS 2.36e-07 44.66 13.30 6.78e-05 1.77e-03
5LUM, DCN, BGN, VCAN, PRELP
 56
GOBP_CONNECTIVE_TISSUE_DEVELOPMENT 1.04e-11 25.05 11.43 1.11e-08 7.78e-08
11COL1A1, LUM, MGP, SFRP2, TIMP1, BGN, LOX, COL5A1, COMP, SULF1, CCN2
 242
GOBP_ENDODERMAL_CELL_DIFFERENTIATION 3.86e-06 44.56 11.13 6.56e-04 2.89e-02
4COL5A1, INHBA, COL6A1, FN1
 44
GOBP_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS 2.98e-05 59.46 11.02 3.53e-03 2.23e-01
3DCN, BGN, VCAN
 25
GOBP_AMINOGLYCAN_CATABOLIC_PROCESS 6.29e-07 36.16 10.85 1.68e-04 4.71e-03
5LUM, DCN, BGN, VCAN, PRELP
 68
GOBP_CARTILAGE_DEVELOPMENT 5.06e-10 25.74 10.83 2.70e-07 3.79e-06
9COL1A1, LUM, MGP, SFRP2, TIMP1, BGN, COMP, SULF1, CCN2
 184
GOBP_BONE_DEVELOPMENT 7.36e-10 24.62 10.37 3.67e-07 5.50e-06
9COL1A1, SFRP4, SFRP2, BGN, LOX, COMP, FBN1, SULF1, TMEM119
 192
GOBP_OSSIFICATION 3.24e-13 20.75 10.25 4.85e-10 2.42e-09
14COL1A2, COL1A1, MGP, SPARC, SFRP2, IGFBP5, VCAN, CTHRC1, LOX, COMP, TMEM119, COL6A1, CCN2, CDH11
 399

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Immunological Gene Sets:

P-value OR Lower 95% CI FDR FWER Genes Found Gene Set Size
GSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN 9.01e-09 23.27 9.29 2.36e-05 4.39e-05
8MGP, SPARC, CCDC80, LOX, TMEM119, F2R, LRRC32, FMO2
 176
GSE2405_0H_VS_1.5H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 2.42e-08 20.36 8.15 2.36e-05 1.18e-04
8COL3A1, COL1A2, SFRP4, MGP, CCDC80, C1R, PRELP, S100A11
 200
GSE4748_CTRL_VS_LPS_STIM_DC_3H_UP 2.42e-08 20.36 8.15 2.36e-05 1.18e-04
8COL3A1, POSTN, PRSS23, FBN1, INHBA, FSTL1, CCN2, CDH11
 200
GSE28737_BCL6_HET_VS_BCL6_KO_FOLLICULAR_BCELL_DN 2.42e-08 20.36 8.15 2.36e-05 1.18e-04
8COL1A2, COL1A1, SPARC, BGN, LOX, FBLN2, COL6A3, FSTL1
 200
GSE43955_1H_VS_10H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN 2.42e-08 20.36 8.15 2.36e-05 1.18e-04
8COL1A2, DCN, BGN, FBLN2, LTBP2, FN1, CCN2, S100A11
 200
GSE26488_WT_VS_HDAC7_DELTAP_TG_OT2_THYMOCYTE_WITH_PEPTIDE_INJECTION_DN 4.68e-07 17.41 6.52 2.36e-04 2.28e-03
7POSTN, BGN, FBLN2, PRSS23, FSTL1, COL6A2, CCN2
 199
GSE2405_0H_VS_3H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_UP 4.84e-07 17.32 6.49 2.36e-04 2.36e-03
7COL1A2, TIMP1, BGN, IGFBP7, LTBP2, COL6A3, S100A11
 200
GSE8835_HEALTHY_VS_CLL_CD8_TCELL_DN 4.84e-07 17.32 6.49 2.36e-04 2.36e-03
7COL3A1, COL1A2, COL1A1, LUM, DCN, COL5A1, TMEM119
 200
GSE2585_CTEC_VS_THYMIC_MACROPHAGE_UP 4.84e-07 17.32 6.49 2.36e-04 2.36e-03
7COL1A1, DCN, IGFBP7, PRSS23, FSTL1, TMEM119, COL14A1
 200
GSE43955_10H_VS_60H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN 4.84e-07 17.32 6.49 2.36e-04 2.36e-03
7COL1A2, COL1A1, MGP, THBS2, AEBP1, INHBA, S100A11
 200
GSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_UP 7.77e-06 14.58 5.02 2.50e-03 3.78e-02
6THBS2, VCAN, COL6A3, COL6A1, IGFBP4, FN1
 198
GSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_24H_UP 7.99e-06 14.51 4.99 2.50e-03 3.89e-02
6COL1A1, SPARC, THBS2, CTHRC1, FSTL1, COL14A1
 199
GSE3039_CD4_TCELL_VS_B2_BCELL_UP 8.22e-06 14.43 4.97 2.50e-03 4.01e-02
6BGN, FSTL1, IGFBP4, FN1, S100A11, CDH11
 200
GSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_UP 8.22e-06 14.43 4.97 2.50e-03 4.01e-02
6COL3A1, LUM, DCN, TIMP1, C1R, COL6A1
 200
GSE37301_RAG2_KO_VS_RAG2_AND_ETS1_KO_NK_CELL_UP 8.22e-06 14.43 4.97 2.50e-03 4.01e-02
6COL1A1, CCDC80, FBN1, COL6A2, COL6A1, COL14A1
 200
GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN 8.22e-06 14.43 4.97 2.50e-03 4.01e-02
6COL1A2, MGP, DCN, AEBP1, COL10A1, FBN1
 200
GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_DN 5.46e-05 13.83 4.23 1.57e-02 2.66e-01
5COL1A1, DCN, IGFBP5, FBLN2, FSTL1
 170
GSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN 1.14e-04 11.76 3.60 2.48e-02 5.57e-01
5SPARC, THBS2, COL6A3, COL6A1, IGFBP4
 199
GSE17721_0.5H_VS_24H_CPG_BMDC_DN 1.17e-04 11.70 3.59 2.48e-02 5.70e-01
5LOX, COL5A1, FSTL1, TMEM119, IGFBP4
 200
GSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN 1.17e-04 11.70 3.59 2.48e-02 5.70e-01
5SPARC, AEBP1, LTBP2, SULF1, COL6A1
 200

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Top Ranked Transcription Factors for this Gene Expression Program:

Gene Symbol Gene Loading Rank DNA Binding Domain Motif Status IUPAC PWM GTEx DepMap Decartes
SFRP4 4 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
AEBP1 16 Yes Likely to be sequence specific TF Monomer or homomultimer No motif None This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).
FBN1 34 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
GAS6 52 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
ID3 62 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
NR2F2 64 Yes Known motif Monomer or homomultimer 100 perc ID - in vitro None None
PTGIS 76 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None It is a cytochrome p450 enzyme
PRRX1 92 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CYP1B1 108 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
FZD4 111 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None
SIX1 118 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
TNFSF18 123 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Protein is a cytokine
MN1 124 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Evidence for DNA binding not strong in (PMID: 12569362)
FHL2 147 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None LIM ZF proteins are unlikely to bind DNA. Experimental evidence does not support a role for FHL2 as a sequence-specific DNA-binding protein (PMID:10654935)
ID4 155 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None ID bHLH proteins lack the basic region and should not be able to bind DNA. The HT-SELEX motif for ID4 is likely by a co-precipitated protein or it is a contamination
NR2F1 160 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
CREB3L1 162 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FLNA 169 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None Go annotation is based on (PMID: 15684392), which shows that it binds FOXC1 and PBX1 but doesnt show evidence for binding to DNA
HIC1 172 Yes Known motif Monomer or homomultimer High-throughput in vitro None None
FZD1 175 No Unlikely to be sequence specific TF Not a DNA binding protein No motif None None

Druggable Genes for this Gene Expression Program:

Gene Symbol Gene Loading Rank Drug Names Drug Category GTEx DepMap
F2R 40
1VORAPAXAR
 Small molecule GTEx DepMap
ITGB1 66
1VOLOCIXIMAB
 Antibody GTEx DepMap
PDGFRA 69
4REGORAFENIB, PAZOPANIB, NINTEDANIB, SUNITINIB
 Small molecule GTEx DepMap
ANO1 97
1CROFELEMER
 Small molecule GTEx DepMap
EDNRA 131
3MACITENTAN, BOSENTAN, AMBRISENTAN
 Small molecule GTEx DepMap
FZD7 145
1VANTICTUMAB
 Antibody GTEx DepMap
PDE1A 146
2PENTOXIFYLLINE, DIPYRIDAMOLE
 Small molecule GTEx DepMap
FZD1 175
1VANTICTUMAB
 Antibody GTEx DepMap
FZD8 177
1VANTICTUMAB
 Antibody GTEx DepMap
EPHA3 210
1VANDETANIB
 Small molecule GTEx DepMap
PDGFRB 294
7SORAFENIB, IMATINIB, REGORAFENIB, PAZOPANIB, NINTEDANIB, SUNITINIB, DASATINIB
 Small molecule GTEx DepMap
HTR2B 303
2METHYLERGONOVINE, METHYSERGIDE
 Small molecule GTEx DepMap
RARG 340
7TAZAROTENE, ALITRETINOIN, TRETINOIN, ISOTRETINOIN, ETRETINATE, ADAPALENE, ACITRETIN
 Small molecule GTEx DepMap
DHFR 373
3PEMETREXED DISODIUM, PRALATREXATE, METHOTREXATE
 Small molecule GTEx DepMap
ACVRL1 439
1Panulisib
 Small molecule GTEx DepMap
ACVRL1 439
1PF-03446962
 Antibody GTEx DepMap
PGR 440
19ETHYNODIOL DIACETATE, MIFEPRISTONE, NORGESTREL, HYDROXYPROGESTERONE CAPROATE, DYDROGESTERONE, NORGESTIMATE, NORELGESTROMIN, MEGESTROL ACETATE, NORETHINDRONE ACETATE, MEDROXYPROGESTERONE ACETATE, PROGESTERONE, NORETHYNODREL, LEVONORGESTREL, NORETHINDRONE, DROSPIRENONE, ETONOGESTREL, DESOGESTREL, ULIPRISTAL ACETATE, DANAZOL
 Small molecule GTEx DepMap
SLC29A1 484
1DIPYRIDAMOLE
 Small molecule GTEx DepMap
S1PR5 535
1FINGOLIMOD
 Small molecule GTEx DepMap
ADH1B 544
1FOMEPIZOLE
 Small molecule GTEx DepMap
FZD2 594
1VANTICTUMAB
 Antibody GTEx DepMap


QQ Plot showing correlations with other GEPs in this dataset, calculated by Spearman correlation:

Interactive QQ-plot of gene loadings:

Interactive QQ Plot

A similar QQ-plot as above, but only for instances where the H value is e.g. > 25, i.e. we are confident that the expression program is active above noise. Agreemenet between these binary vectors is tested using the Jaccard Index, with the P-values calculated by an exact test:

Interactive QQ-plot:

Interactive QQ Plot

Singler cell type annotations for the top 50 cells on this program.

Cell ID Singler label Singler Delta Activity Score Top Singler Raw Scores
CTGGACGTCCGCGATG-1_HTA4_1018_4071 Fibroblasts 0.34 3994.31
Raw ScoresFibroblasts: 0.43, Osteoblasts: 0.42, Chondrocytes: 0.42, Tissue_stem_cells: 0.41, Smooth_muscle_cells: 0.4, MSC: 0.38, iPS_cells: 0.38, Neurons: 0.32, Endothelial_cells: 0.27, Neuroepithelial_cell: 0.26
GACGTTAGTCAAGCCC-1_HTA4_1018_4070 Smooth_muscle_cells 0.34 3816.26
Raw ScoresFibroblasts: 0.51, Osteoblasts: 0.5, Chondrocytes: 0.49, Smooth_muscle_cells: 0.48, Tissue_stem_cells: 0.47, iPS_cells: 0.45, MSC: 0.44, Neurons: 0.37, Endothelial_cells: 0.34, Astrocyte: 0.32
TGAGGGACAAAGCACG-1_HTA4_1018_4071 Smooth_muscle_cells 0.35 3813.16
Raw ScoresFibroblasts: 0.53, Chondrocytes: 0.51, Smooth_muscle_cells: 0.51, Osteoblasts: 0.5, Tissue_stem_cells: 0.48, iPS_cells: 0.47, MSC: 0.46, Neurons: 0.4, Endothelial_cells: 0.36, Astrocyte: 0.34
GAATAGAAGAACAGGA-1_HTA4_1018_4070 Fibroblasts 0.36 2970.42
Raw ScoresFibroblasts: 0.53, Smooth_muscle_cells: 0.51, Osteoblasts: 0.51, Chondrocytes: 0.51, Tissue_stem_cells: 0.49, iPS_cells: 0.47, MSC: 0.46, Neurons: 0.41, Endothelial_cells: 0.37, Astrocyte: 0.33
GTCTCACTCAAAGGAT-1_HTA4_1012_4045 Smooth_muscle_cells 0.32 2614.50
Raw ScoresFibroblasts: 0.55, Osteoblasts: 0.55, Smooth_muscle_cells: 0.54, MSC: 0.52, iPS_cells: 0.51, Tissue_stem_cells: 0.51, Chondrocytes: 0.51, Neurons: 0.44, Endothelial_cells: 0.43, Astrocyte: 0.37
ATTACTCGTACTTCCC-1_HTA4_1018_4071 Tissue_stem_cells 0.31 2393.31
Raw ScoresFibroblasts: 0.43, Chondrocytes: 0.42, Smooth_muscle_cells: 0.42, Osteoblasts: 0.41, Tissue_stem_cells: 0.41, iPS_cells: 0.38, MSC: 0.36, Neurons: 0.32, Endothelial_cells: 0.27, Astrocyte: 0.24
GCTCAAATCCTTTGAT-1_HTA4_1018_4071 Fibroblasts 0.38 2308.16
Raw ScoresFibroblasts: 0.5, Osteoblasts: 0.47, Smooth_muscle_cells: 0.46, Chondrocytes: 0.46, Tissue_stem_cells: 0.44, iPS_cells: 0.43, MSC: 0.42, Neurons: 0.34, Endothelial_cells: 0.32, Astrocyte: 0.29
TGTTGGATCCCAGGCA-1_HTA4_1018_4070 Fibroblasts 0.34 2240.68
Raw ScoresFibroblasts: 0.44, Chondrocytes: 0.42, Smooth_muscle_cells: 0.41, Osteoblasts: 0.41, Tissue_stem_cells: 0.4, iPS_cells: 0.38, MSC: 0.36, Neurons: 0.32, Endothelial_cells: 0.28, Astrocyte: 0.24
TCATCCGGTGGTACAG-1_HTA4_1018_4071 Tissue_stem_cells 0.30 2049.54
Raw ScoresFibroblasts: 0.42, Chondrocytes: 0.42, Osteoblasts: 0.41, Tissue_stem_cells: 0.4, Smooth_muscle_cells: 0.39, iPS_cells: 0.37, MSC: 0.37, Neurons: 0.32, Endothelial_cells: 0.28, Neuroepithelial_cell: 0.25
AAGACAACAGGATGAC-1_HTA4_1018_4070 Smooth_muscle_cells 0.34 1855.21
Raw ScoresFibroblasts: 0.51, Osteoblasts: 0.49, Chondrocytes: 0.49, Smooth_muscle_cells: 0.49, Tissue_stem_cells: 0.46, iPS_cells: 0.44, MSC: 0.43, Neurons: 0.39, Endothelial_cells: 0.34, Astrocyte: 0.33
TCCTAATCATGGCCAC-1_HTA4_1018_4070 Chondrocytes 0.32 1848.28
Raw ScoresFibroblasts: 0.39, Chondrocytes: 0.38, Osteoblasts: 0.38, Smooth_muscle_cells: 0.36, Tissue_stem_cells: 0.36, iPS_cells: 0.34, MSC: 0.33, Neurons: 0.28, Endothelial_cells: 0.24, Neuroepithelial_cell: 0.22
GAGTCATTCCCATGGG-1_HTA4_1018_4070 Smooth_muscle_cells 0.34 1825.16
Raw ScoresFibroblasts: 0.52, Osteoblasts: 0.49, Smooth_muscle_cells: 0.49, Chondrocytes: 0.49, Tissue_stem_cells: 0.47, iPS_cells: 0.46, MSC: 0.46, Neurons: 0.38, Endothelial_cells: 0.36, Astrocyte: 0.33
CTTCGGTGTAGCGCTC-1_HTA4_1018_4070 Fibroblasts 0.30 1812.39
Raw ScoresFibroblasts: 0.42, Osteoblasts: 0.42, Chondrocytes: 0.41, Tissue_stem_cells: 0.4, Smooth_muscle_cells: 0.4, MSC: 0.38, iPS_cells: 0.38, Neurons: 0.33, Endothelial_cells: 0.29, Astrocyte: 0.25
CACAACAGTTACCCAA-1_HTA4_1018_4071 Fibroblasts 0.36 1747.78
Raw ScoresFibroblasts: 0.47, Osteoblasts: 0.45, Smooth_muscle_cells: 0.45, Chondrocytes: 0.44, Tissue_stem_cells: 0.43, MSC: 0.41, iPS_cells: 0.41, Neurons: 0.34, Endothelial_cells: 0.31, Astrocyte: 0.28
TGATCAGAGTCCGCGT-1_HTA4_1009_4031 Fibroblasts 0.34 1738.37
Raw ScoresFibroblasts: 0.48, Osteoblasts: 0.47, Chondrocytes: 0.45, Smooth_muscle_cells: 0.45, Tissue_stem_cells: 0.44, iPS_cells: 0.42, MSC: 0.42, Neurons: 0.36, Astrocyte: 0.33, Endothelial_cells: 0.32
GAAGGGTAGCTCGCAC-1_HTA4_1020_4077 Smooth_muscle_cells 0.30 1682.81
Raw ScoresOsteoblasts: 0.53, Fibroblasts: 0.53, Smooth_muscle_cells: 0.51, Tissue_stem_cells: 0.5, Chondrocytes: 0.5, MSC: 0.48, iPS_cells: 0.47, Neurons: 0.4, Endothelial_cells: 0.4, Astrocyte: 0.36
TCTTCCTGTCCTTGTC-1_HTA4_1018_4071 Fibroblasts 0.33 1672.51
Raw ScoresFibroblasts: 0.43, Osteoblasts: 0.42, Chondrocytes: 0.42, Smooth_muscle_cells: 0.41, Tissue_stem_cells: 0.4, iPS_cells: 0.38, MSC: 0.38, Neurons: 0.33, Endothelial_cells: 0.29, Astrocyte: 0.26
ATTTACCCATGGGAAC-1_HTA4_1002_4008 Smooth_muscle_cells 0.17 1669.13
Raw ScoresFibroblasts: 0.32, Osteoblasts: 0.31, Chondrocytes: 0.31, Smooth_muscle_cells: 0.31, Tissue_stem_cells: 0.29, iPS_cells: 0.28, MSC: 0.28, Neurons: 0.24, Astrocyte: 0.23, Endothelial_cells: 0.22
GTAGATCCAGCGTATT-1_HTA4_1018_4071 Smooth_muscle_cells 0.30 1632.83
Raw ScoresFibroblasts: 0.37, Chondrocytes: 0.36, Smooth_muscle_cells: 0.36, Osteoblasts: 0.35, Tissue_stem_cells: 0.34, iPS_cells: 0.32, MSC: 0.31, Neurons: 0.26, Endothelial_cells: 0.22, Astrocyte: 0.21
CCTCCAAAGGTCACTT-1_HTA4_1018_4066 Smooth_muscle_cells 0.28 1631.64
Raw ScoresFibroblasts: 0.47, Osteoblasts: 0.47, Smooth_muscle_cells: 0.44, Chondrocytes: 0.43, Tissue_stem_cells: 0.43, iPS_cells: 0.41, MSC: 0.41, Neurons: 0.35, Endothelial_cells: 0.34, Astrocyte: 0.32
TACGGGCTCAAATAGG-1_HTA4_1018_4071 Chondrocytes 0.32 1614.00
Raw ScoresFibroblasts: 0.46, Osteoblasts: 0.45, Smooth_muscle_cells: 0.45, Chondrocytes: 0.45, Tissue_stem_cells: 0.44, iPS_cells: 0.42, MSC: 0.41, Neurons: 0.35, Endothelial_cells: 0.3, Astrocyte: 0.27
TCCTTCTTCCGCATAA-1_HTA4_1012_4046 Smooth_muscle_cells 0.29 1599.77
Raw ScoresFibroblasts: 0.5, Smooth_muscle_cells: 0.48, Chondrocytes: 0.48, Osteoblasts: 0.47, Tissue_stem_cells: 0.46, iPS_cells: 0.44, MSC: 0.44, Neurons: 0.37, Endothelial_cells: 0.36, Embryonic_stem_cells: 0.34
GAAATGACATAGGCGA-1_HTA4_1018_4070 Smooth_muscle_cells 0.29 1578.69
Raw ScoresFibroblasts: 0.41, Chondrocytes: 0.4, Smooth_muscle_cells: 0.4, Osteoblasts: 0.39, Tissue_stem_cells: 0.38, iPS_cells: 0.36, MSC: 0.36, Neurons: 0.31, Endothelial_cells: 0.27, Neuroepithelial_cell: 0.23
CTGCCTATCATTTGGG-1_HTA4_1018_4070 Smooth_muscle_cells 0.32 1577.23
Raw ScoresFibroblasts: 0.49, Osteoblasts: 0.47, Smooth_muscle_cells: 0.47, Chondrocytes: 0.46, Tissue_stem_cells: 0.45, iPS_cells: 0.43, MSC: 0.41, Neurons: 0.36, Endothelial_cells: 0.33, Astrocyte: 0.3
CTCAATTAGGATACGC-1_HTA4_1021_4082 Fibroblasts 0.29 1557.47
Raw ScoresFibroblasts: 0.46, Smooth_muscle_cells: 0.44, Chondrocytes: 0.44, Osteoblasts: 0.43, Tissue_stem_cells: 0.42, iPS_cells: 0.4, MSC: 0.4, Astrocyte: 0.36, Neurons: 0.35, Neuroepithelial_cell: 0.35
AGTTCGACATTGACCA-1_HTA4_1018_4070 Smooth_muscle_cells 0.31 1493.49
Raw ScoresFibroblasts: 0.45, Smooth_muscle_cells: 0.44, Osteoblasts: 0.43, Chondrocytes: 0.42, Tissue_stem_cells: 0.41, iPS_cells: 0.4, MSC: 0.39, Neurons: 0.34, Endothelial_cells: 0.32, Neuroepithelial_cell: 0.28
CATAAGCAGAGAGTTT-1_HTA4_1018_4071 Fibroblasts 0.37 1488.36
Raw ScoresFibroblasts: 0.51, Chondrocytes: 0.48, Osteoblasts: 0.48, Smooth_muscle_cells: 0.47, Tissue_stem_cells: 0.45, iPS_cells: 0.44, MSC: 0.43, Neurons: 0.38, Endothelial_cells: 0.34, Astrocyte: 0.33
TTGGATGTCGAAACAA-1_HTA4_1018_4071 Fibroblasts 0.26 1385.87
Raw ScoresChondrocytes: 0.36, Fibroblasts: 0.36, Osteoblasts: 0.35, Tissue_stem_cells: 0.35, Smooth_muscle_cells: 0.34, iPS_cells: 0.32, MSC: 0.31, Neurons: 0.27, Endothelial_cells: 0.24, Embryonic_stem_cells: 0.2
GACTGATCATGGCTGC-1_HTA4_1018_4070 Smooth_muscle_cells 0.24 1361.70
Raw ScoresFibroblasts: 0.39, Smooth_muscle_cells: 0.39, Chondrocytes: 0.37, Tissue_stem_cells: 0.37, Osteoblasts: 0.37, iPS_cells: 0.36, MSC: 0.36, Neurons: 0.32, Endothelial_cells: 0.29, Neuroepithelial_cell: 0.25
CATTTCAGTTAGGGAC-1_HTA4_1018_4071 Fibroblasts 0.32 1360.67
Raw ScoresFibroblasts: 0.42, Osteoblasts: 0.4, Chondrocytes: 0.4, Smooth_muscle_cells: 0.4, Tissue_stem_cells: 0.39, iPS_cells: 0.37, MSC: 0.36, Neurons: 0.31, Endothelial_cells: 0.27, Neuroepithelial_cell: 0.23
CATACAGAGTGATAGT-1_HTA4_1018_4071 Fibroblasts 0.30 1344.62
Raw ScoresFibroblasts: 0.41, Osteoblasts: 0.4, Chondrocytes: 0.39, Smooth_muscle_cells: 0.38, Tissue_stem_cells: 0.38, iPS_cells: 0.36, MSC: 0.36, Neurons: 0.31, Endothelial_cells: 0.26, Neuroepithelial_cell: 0.24
ATTTCTGTCGTAATGC-1_HTA4_1018_4070 Smooth_muscle_cells 0.30 1344.60
Raw ScoresFibroblasts: 0.45, Smooth_muscle_cells: 0.43, Osteoblasts: 0.43, Chondrocytes: 0.42, Tissue_stem_cells: 0.42, iPS_cells: 0.4, MSC: 0.39, Neurons: 0.34, Endothelial_cells: 0.32, Neuroepithelial_cell: 0.27
GGAGCAAAGTGAATAC-1_HTA4_1018_4071 Fibroblasts 0.32 1338.35
Raw ScoresFibroblasts: 0.42, Chondrocytes: 0.41, Smooth_muscle_cells: 0.4, Osteoblasts: 0.4, Tissue_stem_cells: 0.39, iPS_cells: 0.36, MSC: 0.36, Neurons: 0.3, Endothelial_cells: 0.27, Neuroepithelial_cell: 0.25
ATTCTACTCAAACGAA-1_HTA4_1018_4071 Chondrocytes 0.29 1335.56
Raw ScoresChondrocytes: 0.35, Fibroblasts: 0.34, Osteoblasts: 0.34, Tissue_stem_cells: 0.33, Smooth_muscle_cells: 0.33, iPS_cells: 0.3, MSC: 0.3, Neurons: 0.25, Endothelial_cells: 0.2, Astrocyte: 0.2
CTTCTCTCACACAGAG-1_HTA4_1018_4070 Chondrocytes 0.30 1248.65
Raw ScoresFibroblasts: 0.4, Chondrocytes: 0.39, Osteoblasts: 0.38, Tissue_stem_cells: 0.38, Smooth_muscle_cells: 0.37, iPS_cells: 0.35, MSC: 0.33, Neurons: 0.29, Endothelial_cells: 0.24, Astrocyte: 0.22
ATGAGTCCAGGTGTGA-1_HTA4_1020_4077 Osteoblasts 0.28 1243.63
Raw ScoresOsteoblasts: 0.39, Smooth_muscle_cells: 0.38, Fibroblasts: 0.38, Chondrocytes: 0.38, Tissue_stem_cells: 0.38, MSC: 0.37, iPS_cells: 0.36, Neurons: 0.31, Endothelial_cells: 0.29, Neuroepithelial_cell: 0.25
ATCGATGTCTAGGCAT-1_HTA4_1018_4070 Smooth_muscle_cells 0.28 1242.07
Raw ScoresFibroblasts: 0.35, Smooth_muscle_cells: 0.34, Chondrocytes: 0.34, Osteoblasts: 0.34, Tissue_stem_cells: 0.33, iPS_cells: 0.31, MSC: 0.3, Neurons: 0.25, Neuroepithelial_cell: 0.22, Endothelial_cells: 0.21
ATCAGGTCACAAGCCC-1_HTA4_1018_4070 Fibroblasts 0.29 1231.38
Raw ScoresFibroblasts: 0.41, Chondrocytes: 0.4, Osteoblasts: 0.39, Tissue_stem_cells: 0.39, Smooth_muscle_cells: 0.38, iPS_cells: 0.37, MSC: 0.36, Neurons: 0.31, Endothelial_cells: 0.26, Neuroepithelial_cell: 0.23
AAACGAACAAGGTCGA-1_HTA4_1018_4070 Smooth_muscle_cells 0.27 1191.27
Raw ScoresChondrocytes: 0.35, Fibroblasts: 0.35, Osteoblasts: 0.34, Smooth_muscle_cells: 0.33, Tissue_stem_cells: 0.33, iPS_cells: 0.31, MSC: 0.3, Neurons: 0.25, Endothelial_cells: 0.21, Astrocyte: 0.19
ATATCCTCAGGACATG-1_HTA4_1018_4071 Smooth_muscle_cells 0.28 1190.83
Raw ScoresFibroblasts: 0.4, Chondrocytes: 0.38, Osteoblasts: 0.38, Smooth_muscle_cells: 0.37, Tissue_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.34, Neurons: 0.31, Endothelial_cells: 0.25, Neuroepithelial_cell: 0.23
ACGATCATCCCAAGTA-1_HTA4_1004_4014 Tissue_stem_cells 0.25 1184.76
Raw ScoresFibroblasts: 0.46, Osteoblasts: 0.45, Tissue_stem_cells: 0.45, Smooth_muscle_cells: 0.44, Chondrocytes: 0.44, iPS_cells: 0.41, MSC: 0.41, Neurons: 0.38, Endothelial_cells: 0.35, Astrocyte: 0.32
GGGTCACGTCTATGAC-1_HTA4_1018_4070 Smooth_muscle_cells 0.30 1149.26
Raw ScoresFibroblasts: 0.4, Osteoblasts: 0.39, Chondrocytes: 0.38, Smooth_muscle_cells: 0.38, Tissue_stem_cells: 0.37, iPS_cells: 0.36, MSC: 0.35, Neurons: 0.31, Endothelial_cells: 0.26, Embryonic_stem_cells: 0.22
ATAGACCCATCGTGCG-1_HTA4_1009_4033 Fibroblasts 0.31 1121.33
Raw ScoresFibroblasts: 0.47, Osteoblasts: 0.44, Chondrocytes: 0.43, Smooth_muscle_cells: 0.42, Tissue_stem_cells: 0.41, iPS_cells: 0.41, MSC: 0.4, Neurons: 0.35, Astrocyte: 0.32, Endothelial_cells: 0.31
ATTTACCAGAAATTCG-1_HTA4_1018_4070 Fibroblasts 0.39 1120.95
Raw ScoresFibroblasts: 0.55, Osteoblasts: 0.52, Smooth_muscle_cells: 0.52, Chondrocytes: 0.51, Tissue_stem_cells: 0.49, iPS_cells: 0.48, MSC: 0.48, Neurons: 0.4, Endothelial_cells: 0.38, Astrocyte: 0.37
TGCATCCCAATAACCC-1_HTA4_1018_4071 Smooth_muscle_cells 0.28 1111.43
Raw ScoresFibroblasts: 0.38, Chondrocytes: 0.37, Osteoblasts: 0.37, Smooth_muscle_cells: 0.37, Tissue_stem_cells: 0.36, iPS_cells: 0.34, MSC: 0.33, Neurons: 0.27, Endothelial_cells: 0.23, Astrocyte: 0.21
AGAAGCGAGCACGGAT-1_HTA4_1012_4046 Fibroblasts 0.28 1107.80
Raw ScoresFibroblasts: 0.43, Smooth_muscle_cells: 0.4, Osteoblasts: 0.4, Chondrocytes: 0.4, Tissue_stem_cells: 0.39, iPS_cells: 0.38, MSC: 0.37, Neurons: 0.32, Endothelial_cells: 0.29, Astrocyte: 0.27
AGCGTATGTATGCGTT-1_HTA4_1018_4070 Fibroblasts 0.31 1104.20
Raw ScoresFibroblasts: 0.43, Smooth_muscle_cells: 0.42, Osteoblasts: 0.41, Chondrocytes: 0.41, Tissue_stem_cells: 0.39, iPS_cells: 0.37, MSC: 0.37, Neurons: 0.32, Endothelial_cells: 0.29, Astrocyte: 0.28
GGGACAAGTGTACGCC-1_HTA4_1020_4077 Smooth_muscle_cells 0.28 1099.41
Raw ScoresOsteoblasts: 0.43, Fibroblasts: 0.43, Smooth_muscle_cells: 0.41, Chondrocytes: 0.41, Tissue_stem_cells: 0.4, MSC: 0.38, iPS_cells: 0.38, Endothelial_cells: 0.31, Neurons: 0.31, Astrocyte: 0.28
AAAGGGCCAACACGAG-1_HTA4_1009_4031 Smooth_muscle_cells 0.28 1096.44
Raw ScoresFibroblasts: 0.43, Smooth_muscle_cells: 0.43, Osteoblasts: 0.42, Chondrocytes: 0.41, Tissue_stem_cells: 0.4, MSC: 0.39, iPS_cells: 0.39, Neurons: 0.36, Astrocyte: 0.33, Endothelial_cells: 0.31
CCAAGCGCAGGTGACA-1_HTA4_1009_4031 Tissue_stem_cells 0.29 1095.12
Raw ScoresFibroblasts: 0.48, Chondrocytes: 0.47, Tissue_stem_cells: 0.47, Osteoblasts: 0.47, Smooth_muscle_cells: 0.46, iPS_cells: 0.44, MSC: 0.43, Neurons: 0.38, Endothelial_cells: 0.33, Astrocyte: 0.32


Below shows the significant enrichments of this GEP for literature curated gene lists
   This data was procured from existing single cell RNA-seq maps of neuroblastoma or related relevant data.
  High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by the P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Myofibroblastic CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain myofibroblastic specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.78e-16
Mean rank of genes in gene set: 3458.06
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL3A1 0.0091022 1 GTEx DepMap Descartes 22.70 2636.24
COL1A2 0.0090765 2 GTEx DepMap Descartes 25.13 2704.87
COL1A1 0.0089022 3 GTEx DepMap Descartes 26.11 2919.87
LUM 0.0079013 5 GTEx DepMap Descartes 3.34 760.33
THBS2 0.0063489 8 GTEx DepMap Descartes 4.80 493.88
DCN 0.0057837 10 GTEx DepMap Descartes 3.84 333.99
POSTN 0.0053938 12 GTEx DepMap Descartes 5.02 937.88
BGN 0.0051920 14 GTEx DepMap Descartes 2.39 648.30
COL10A1 0.0048890 17 GTEx DepMap Descartes 0.60 97.47
IGFBP7 0.0047647 18 GTEx DepMap Descartes 19.11 7926.95
VCAN 0.0047246 19 GTEx DepMap Descartes 7.91 358.23
COL5A1 0.0044354 23 GTEx DepMap Descartes 4.10 307.10
TMEM119 0.0032448 39 GTEx DepMap Descartes 0.28 61.50
FN1 0.0029355 44 GTEx DepMap Descartes 11.91 778.73
COL14A1 0.0029033 45 GTEx DepMap Descartes 3.23 243.58
COL5A2 0.0026329 57 GTEx DepMap Descartes 5.51 475.88
COL8A1 0.0025133 63 GTEx DepMap Descartes 3.67 347.57
TAGLN 0.0024799 65 GTEx DepMap Descartes 2.21 346.56
IGFBP3 0.0021357 74 GTEx DepMap Descartes 0.61 120.08
THY1 0.0019204 82 GTEx DepMap Descartes 1.98 236.48
COL4A1 0.0014065 125 GTEx DepMap Descartes 9.74 879.09
TPM2 0.0013033 142 GTEx DepMap Descartes 0.89 325.20
MYL9 0.0012771 152 GTEx DepMap Descartes 0.98 201.36
COL12A1 0.0011773 170 GTEx DepMap Descartes 3.33 163.95
COL11A1 0.0010560 206 GTEx DepMap Descartes 1.01 71.52
MMP2 0.0010396 208 GTEx DepMap Descartes 0.53 91.05
HOPX 0.0009420 229 GTEx DepMap Descartes 0.30 44.65
MMP11 0.0009313 234 GTEx DepMap Descartes 0.36 58.32
THBS1 0.0008961 248 GTEx DepMap Descartes 4.47 326.27
ACTA2 0.0007501 296 GTEx DepMap Descartes 1.95 823.55
CNN2 0.0005511 438 GTEx DepMap Descartes 0.28 71.99
CNN3 0.0004164 582 GTEx DepMap Descartes 1.41 371.95
MYLK 0.0003943 617 GTEx DepMap Descartes 1.14 64.38
TPM1 0.0003800 648 GTEx DepMap Descartes 3.97 576.88
COL15A1 0.0003518 713 GTEx DepMap Descartes 1.49 129.08
TGFB1 0.0002654 942 GTEx DepMap Descartes 0.65 128.24
WNT5A 0.0002463 1018 GTEx DepMap Descartes 0.08 7.04
TGFBR2 0.0001725 1458 GTEx DepMap Descartes 2.02 172.10
TGFBR1 0.0001315 1843 GTEx DepMap Descartes 1.09 89.46
PGF 0.0000782 2845 GTEx DepMap Descartes 0.13 19.67
TGFB2 0.0000569 3517 GTEx DepMap Descartes 0.33 28.03
COL13A1 -0.0000490 15118 GTEx DepMap Descartes 0.05 7.48
ACTG2 -0.0000949 17410 GTEx DepMap Descartes 0.05 13.38
VEGFA -0.0000992 17582 GTEx DepMap Descartes 0.69 26.11
TNC -0.0003171 20261 GTEx DepMap Descartes 2.96 201.34
MEF2C -0.0003462 20343 GTEx DepMap Descartes 1.86 110.18
ITGA7 -0.0003911 20435 GTEx DepMap Descartes 0.19 22.55
RGS5 -0.0004533 20500 GTEx DepMap Descartes 1.47 122.86
MYH11 -0.0005925 20564 GTEx DepMap Descartes 0.41 34.79


Inflammatory CAF
These marker genes were curated across cancer subtypes in multiple organ systems as reviewed in Lavie et. al. (PMID 35883004) and contain inflammatory specific CAF genes:
Wilcoxon ranksum test P-value for gene set overrepresentation: 2.72e-10
Mean rank of genes in gene set: 4467.85
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
C1R 0.0036704 32 GTEx DepMap Descartes 1.10 194.74
C1S 0.0024464 67 GTEx DepMap Descartes 1.60 311.81
PDGFRA 0.0022798 69 GTEx DepMap Descartes 0.42 37.37
IGFBP6 0.0016459 100 GTEx DepMap Descartes 0.35 167.39
C7 0.0014879 117 GTEx DepMap Descartes 6.19 686.04
IGF1 0.0013623 132 GTEx DepMap Descartes 1.01 77.96
CXCL12 0.0013291 140 GTEx DepMap Descartes 0.75 123.25
SERPING1 0.0012778 151 GTEx DepMap Descartes 0.64 165.25
CCL2 0.0009713 218 GTEx DepMap Descartes 0.95 557.22
PDGFRB 0.0007614 294 GTEx DepMap Descartes 1.99 214.50
CFD 0.0007242 311 GTEx DepMap Descartes 0.22 123.05
PDGFD 0.0006118 387 GTEx DepMap Descartes 1.95 241.63
ADH1B 0.0004416 544 GTEx DepMap Descartes 0.46 49.08
CXCL14 0.0003648 678 GTEx DepMap Descartes 0.17 50.32
C3 0.0003016 820 GTEx DepMap Descartes 0.98 119.39
SCARA5 0.0002925 844 GTEx DepMap Descartes 0.04 5.99
HGF 0.0002778 900 GTEx DepMap Descartes 0.45 40.13
IL33 0.0001844 1361 GTEx DepMap Descartes 0.40 85.67
CXCL10 0.0001821 1381 GTEx DepMap Descartes 0.05 19.70
SAA1 0.0001798 1405 GTEx DepMap Descartes 0.04 17.59
C1QA 0.0000969 2401 GTEx DepMap Descartes 0.20 107.30
C1QC 0.0000889 2568 GTEx DepMap Descartes 0.13 58.50
SCARA3 0.0000807 2776 GTEx DepMap Descartes 0.11 13.65
LIF 0.0000804 2785 GTEx DepMap Descartes 0.05 5.83
CXCL9 0.0000770 2870 GTEx DepMap Descartes 0.04 8.29
CFB 0.0000432 4091 GTEx DepMap Descartes 0.01 1.60
C4B 0.0000401 4243 GTEx DepMap Descartes 0.00 0.15
CXCL1 0.0000389 4301 GTEx DepMap Descartes 0.03 12.42
CCL21 0.0000230 5183 GTEx DepMap Descartes 0.60 363.13
CCL7 0.0000059 6730 GTEx DepMap Descartes 0.00 1.96
RGMA -0.0000009 8623 GTEx DepMap Descartes 0.13 5.94
GPX3 -0.0000016 8865 GTEx DepMap Descartes 0.27 78.40
IL10 -0.0000057 10040 GTEx DepMap Descartes 0.00 0.75
IL1R1 -0.0000073 10421 GTEx DepMap Descartes 1.34 148.51
SOD2 -0.0000254 13147 GTEx DepMap Descartes 0.02 0.76
CCL8 -0.0000285 13434 GTEx DepMap Descartes 0.01 6.52
CXCL13 -0.0000552 15546 GTEx DepMap Descartes 0.03 13.09
IL6 -0.0000750 16607 GTEx DepMap Descartes 0.09 29.96
PDPN -0.0000825 16936 GTEx DepMap Descartes 0.10 14.34
CXCL2 -0.0000889 17196 GTEx DepMap Descartes 0.11 49.74


Mesenchymal Fig 1D (Olsen)
Selected mesenchymal marker genes shown in Fig. 1D of Olsen et al. https://www.biorxiv.org/content/10.1101/2020.05.04.077057v1 - these are highly expressed in their mesenchymal cluster on their UMAP.:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.20e-08
Mean rank of genes in gene set: 1099.46
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL3A1 0.0091022 1 GTEx DepMap Descartes 22.70 2636.24
COL1A2 0.0090765 2 GTEx DepMap Descartes 25.13 2704.87
COL1A1 0.0089022 3 GTEx DepMap Descartes 26.11 2919.87
LUM 0.0079013 5 GTEx DepMap Descartes 3.34 760.33
MGP 0.0076330 6 GTEx DepMap Descartes 9.18 3183.28
SPARC 0.0073831 7 GTEx DepMap Descartes 9.06 1554.29
DCN 0.0057837 10 GTEx DepMap Descartes 3.84 333.99
BGN 0.0051920 14 GTEx DepMap Descartes 2.39 648.30
COL6A2 0.0032523 38 GTEx DepMap Descartes 3.53 647.18
PDGFRA 0.0022798 69 GTEx DepMap Descartes 0.42 37.37
PRRX1 0.0017384 92 GTEx DepMap Descartes 2.56 370.34
CALD1 0.0006346 369 GTEx DepMap Descartes 12.44 1425.69
LEPR -0.0000312 13677 GTEx DepMap Descartes 0.62 37.68




Below shows ranks on this GEP for literature curated gene lists for large gene sets
  These include those reported as mesenchymal/adrenergic by Van Groningen et al.
  High ranks indicate this gene is a driver of this GEP (note these results are not ordered).
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


VanGroningen Adrenergic Genes
Adrenergic marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 15875.65
Median rank of genes in gene set: 18024
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
STRA6 0.0007362 304 GTEx DepMap Descartes 0.13 23.25
CYGB 0.0005301 451 GTEx DepMap Descartes 0.42 124.46
HEY1 0.0002147 1179 GTEx DepMap Descartes 0.09 11.01
CD200 0.0002146 1181 GTEx DepMap Descartes 0.67 159.05
DNAJB1 0.0001839 1367 GTEx DepMap Descartes 0.26 60.39
NPTX2 0.0001796 1407 GTEx DepMap Descartes 0.07 14.35
TENM4 0.0001587 1589 GTEx DepMap Descartes 3.43 NA
NAP1L5 0.0001586 1590 GTEx DepMap Descartes 0.31 85.58
GLRX 0.0001503 1671 GTEx DepMap Descartes 0.35 51.17
SETD7 0.0001299 1865 GTEx DepMap Descartes 0.48 32.31
EIF1B 0.0001283 1887 GTEx DepMap Descartes 0.41 227.73
ZNF22 0.0001256 1925 GTEx DepMap Descartes 0.17 43.04
LSM3 0.0001081 2197 GTEx DepMap Descartes 0.23 37.31
TUBB4B 0.0000921 2504 GTEx DepMap Descartes 0.42 103.98
GGCT 0.0000915 2513 GTEx DepMap Descartes 0.13 61.39
MMD 0.0000887 2572 GTEx DepMap Descartes 0.57 96.30
FABP6 0.0000880 2589 GTEx DepMap Descartes 0.18 147.02
DKK1 0.0000864 2628 GTEx DepMap Descartes 0.01 2.77
SCG2 0.0000848 2672 GTEx DepMap Descartes 4.50 990.71
PHPT1 0.0000794 2810 GTEx DepMap Descartes 0.42 176.18
SCG3 0.0000726 3005 GTEx DepMap Descartes 0.67 112.23
PTS 0.0000724 3013 GTEx DepMap Descartes 0.69 307.93
RBP1 0.0000629 3317 GTEx DepMap Descartes 0.51 143.14
C4orf48 0.0000580 3470 GTEx DepMap Descartes 0.61 744.58
CDC42EP3 0.0000575 3487 GTEx DepMap Descartes 0.39 36.08
TCEAL7 0.0000500 3797 GTEx DepMap Descartes 0.35 169.86
TUBB2A 0.0000420 4156 GTEx DepMap Descartes 1.54 523.09
OLFM1 0.0000407 4215 GTEx DepMap Descartes 0.44 70.37
ARL6IP1 0.0000347 4528 GTEx DepMap Descartes 0.03 6.53
AHSA1 0.0000332 4609 GTEx DepMap Descartes 0.26 96.78


VanGroningen Mesenchymal Genes
Mesenchymal marker genes from Supplementary Table 2 of Van Groningen et al. Nature Genetics 2017. These genes were identified by differential expression analysis of mesenchymal-like and adrenergic-like neuroblastoma cell lines.
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.68e-78
Mean rank of genes in gene set: 5232.09
Median rank of genes in gene set: 1205.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL3A1 0.0091022 1 GTEx DepMap Descartes 22.70 2636.24
COL1A1 0.0089022 3 GTEx DepMap Descartes 26.11 2919.87
MGP 0.0076330 6 GTEx DepMap Descartes 9.18 3183.28
SPARC 0.0073831 7 GTEx DepMap Descartes 9.06 1554.29
IGFBP5 0.0055329 11 GTEx DepMap Descartes 5.40 464.83
POSTN 0.0053938 12 GTEx DepMap Descartes 5.02 937.88
TIMP1 0.0052738 13 GTEx DepMap Descartes 4.82 2591.36
BGN 0.0051920 14 GTEx DepMap Descartes 2.39 648.30
CCDC80 0.0051759 15 GTEx DepMap Descartes 2.32 114.52
AEBP1 0.0049027 16 GTEx DepMap Descartes 2.41 382.98
COL5A1 0.0044354 23 GTEx DepMap Descartes 4.10 307.10
COL6A3 0.0038533 30 GTEx DepMap Descartes 6.38 385.35
FBN1 0.0034442 34 GTEx DepMap Descartes 3.67 183.67
FSTL1 0.0033109 37 GTEx DepMap Descartes 2.43 245.20
COL6A2 0.0032523 38 GTEx DepMap Descartes 3.53 647.18
F2R 0.0031486 40 GTEx DepMap Descartes 1.07 164.79
COL6A1 0.0030892 41 GTEx DepMap Descartes 2.51 378.26
FN1 0.0029355 44 GTEx DepMap Descartes 11.91 778.73
CDH11 0.0027664 50 GTEx DepMap Descartes 4.77 393.24
FMOD 0.0027489 51 GTEx DepMap Descartes 0.22 44.49
GPX8 0.0027340 53 GTEx DepMap Descartes 0.30 44.59
SERPINH1 0.0027234 54 GTEx DepMap Descartes 0.95 162.72
COL5A2 0.0026329 57 GTEx DepMap Descartes 5.51 475.88
PPIC 0.0026274 58 GTEx DepMap Descartes 0.30 126.37
ID3 0.0025160 62 GTEx DepMap Descartes 1.08 622.50
ITGB1 0.0024489 66 GTEx DepMap Descartes 3.87 557.66
TM4SF1 0.0022070 70 GTEx DepMap Descartes 0.56 80.27
CYBRD1 0.0021736 73 GTEx DepMap Descartes 0.86 118.83
MXRA5 0.0021195 77 GTEx DepMap Descartes 0.42 26.05
EMILIN1 0.0020923 78 GTEx DepMap Descartes 0.84 136.63


Descartes adrenocortical markers
Top 50 marker genes of adrenocortical cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/adrenocortical/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 14451.22
Median rank of genes in gene set: 14862
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SH3PXD2B 0.0001259 1919 GTEx DepMap Descartes 1.33 90.12
PAPSS2 0.0000449 4004 GTEx DepMap Descartes 1.28 147.16
CYP17A1 0.0000335 4588 GTEx DepMap Descartes 0.27 34.52
PEG3 0.0000291 4823 GTEx DepMap Descartes 0.01 NA
INHA 0.0000168 5660 GTEx DepMap Descartes 0.03 8.36
APOC1 -0.0000005 8477 GTEx DepMap Descartes 0.31 218.40
GSTA4 -0.0000084 10651 GTEx DepMap Descartes 0.50 127.09
HSPE1 -0.0000109 11164 GTEx DepMap Descartes 0.48 328.23
DNER -0.0000145 11754 GTEx DepMap Descartes 0.50 62.85
SCAP -0.0000147 11794 GTEx DepMap Descartes 0.44 44.70
SLC2A14 -0.0000211 12686 GTEx DepMap Descartes 0.06 5.84
SH3BP5 -0.0000213 12702 GTEx DepMap Descartes 1.68 194.83
FDXR -0.0000251 13107 GTEx DepMap Descartes 0.12 17.13
CYP11A1 -0.0000276 13351 GTEx DepMap Descartes 0.38 44.65
MC2R -0.0000285 13432 GTEx DepMap Descartes 0.10 6.61
CYP21A2 -0.0000302 13581 GTEx DepMap Descartes 0.38 41.28
CYP11B1 -0.0000304 13607 GTEx DepMap Descartes 0.66 39.71
STAR -0.0000311 13659 GTEx DepMap Descartes 0.45 34.09
DHCR7 -0.0000348 14009 GTEx DepMap Descartes 0.07 11.55
SCARB1 -0.0000396 14386 GTEx DepMap Descartes 2.17 95.98
FREM2 -0.0000417 14533 GTEx DepMap Descartes 0.05 1.08
FDX1 -0.0000433 14680 GTEx DepMap Descartes 1.52 133.13
CYB5B -0.0000460 14862 GTEx DepMap Descartes 0.60 55.92
NPC1 -0.0000494 15150 GTEx DepMap Descartes 0.60 58.88
TM7SF2 -0.0000567 15651 GTEx DepMap Descartes 0.13 28.53
GRAMD1B -0.0000597 15818 GTEx DepMap Descartes 1.73 58.03
ERN1 -0.0000602 15851 GTEx DepMap Descartes 0.85 39.43
POR -0.0000687 16287 GTEx DepMap Descartes 0.70 109.85
DHCR24 -0.0000867 17120 GTEx DepMap Descartes 0.35 22.35
CLU -0.0000889 17197 GTEx DepMap Descartes 3.25 428.14


Descartes chromaffin markers
Top 50 marker genes of chromaffin cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/chromaffin/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 18457.98
Median rank of genes in gene set: 18976
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
TUBB2A 0.0000420 4156 GTEx DepMap Descartes 1.54 523.09
RPH3A -0.0000367 14164 GTEx DepMap Descartes 0.10 6.24
NPY -0.0000580 15713 GTEx DepMap Descartes 2.29 2423.55
SLC6A2 -0.0000812 16881 GTEx DepMap Descartes 0.12 14.07
MAB21L1 -0.0000900 17242 GTEx DepMap Descartes 0.17 32.68
TMEFF2 -0.0000907 17279 GTEx DepMap Descartes 0.43 54.06
REEP1 -0.0000961 17466 GTEx DepMap Descartes 0.64 62.23
EYA4 -0.0000967 17485 GTEx DepMap Descartes 0.24 15.86
PLXNA4 -0.0000995 17593 GTEx DepMap Descartes 0.89 25.46
ANKFN1 -0.0001018 17688 GTEx DepMap Descartes 0.43 40.11
CNTFR -0.0001045 17789 GTEx DepMap Descartes 0.19 37.98
PTCHD1 -0.0001080 17901 GTEx DepMap Descartes 0.27 6.89
RGMB -0.0001135 18049 GTEx DepMap Descartes 0.31 31.13
IL7 -0.0001158 18132 GTEx DepMap Descartes 1.84 431.75
NTRK1 -0.0001224 18311 GTEx DepMap Descartes 0.31 33.31
CNKSR2 -0.0001280 18432 GTEx DepMap Descartes 1.08 44.84
EPHA6 -0.0001332 18545 GTEx DepMap Descartes 1.15 101.99
GREM1 -0.0001363 18605 GTEx DepMap Descartes 0.44 15.53
RBFOX1 -0.0001399 18696 GTEx DepMap Descartes 9.52 698.45
HS3ST5 -0.0001470 18814 GTEx DepMap Descartes 0.78 86.45
STMN4 -0.0001479 18829 GTEx DepMap Descartes 0.50 119.42
GAL -0.0001558 18976 GTEx DepMap Descartes 0.70 552.64
TUBA1A -0.0001597 19043 GTEx DepMap Descartes 5.30 1578.77
GAP43 -0.0001702 19206 GTEx DepMap Descartes 2.06 477.82
HMX1 -0.0001836 19380 GTEx DepMap Descartes 0.27 50.19
SLC44A5 -0.0001839 19384 GTEx DepMap Descartes 0.73 54.38
STMN2 -0.0002090 19651 GTEx DepMap Descartes 4.62 1319.86
MAP1B -0.0002129 19689 GTEx DepMap Descartes 7.31 298.95
EYA1 -0.0002136 19698 GTEx DepMap Descartes 0.58 50.60
BASP1 -0.0002169 19724 GTEx DepMap Descartes 1.50 445.62


Descartes Vascular_endothelial markers
Top 50 marker genes of Vascular_endothelial cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/vascular_endothelial/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.95e-01
Mean rank of genes in gene set: 9524.84
Median rank of genes in gene set: 9424.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ID1 0.0002325 1074 GTEx DepMap Descartes 0.35 122.09
APLNR 0.0002173 1166 GTEx DepMap Descartes 0.10 15.21
HYAL2 0.0002045 1236 GTEx DepMap Descartes 0.22 23.98
CALCRL 0.0001850 1355 GTEx DepMap Descartes 1.09 84.97
NPR1 0.0001682 1497 GTEx DepMap Descartes 0.05 6.06
ESM1 0.0001569 1607 GTEx DepMap Descartes 0.12 24.63
SOX18 0.0001340 1813 GTEx DepMap Descartes 0.14 32.98
TEK 0.0000992 2363 GTEx DepMap Descartes 0.23 19.07
RAMP2 0.0000958 2423 GTEx DepMap Descartes 0.21 109.74
PODXL 0.0000920 2507 GTEx DepMap Descartes 0.37 24.36
KDR 0.0000712 3045 GTEx DepMap Descartes 0.14 10.72
MMRN2 0.0000698 3091 GTEx DepMap Descartes 0.14 15.45
PLVAP 0.0000663 3209 GTEx DepMap Descartes 0.26 46.07
RASIP1 0.0000543 3603 GTEx DepMap Descartes 0.09 12.70
TM4SF18 0.0000517 3720 GTEx DepMap Descartes 0.06 6.28
SHE 0.0000487 3846 GTEx DepMap Descartes 0.10 6.27
EHD3 0.0000478 3877 GTEx DepMap Descartes 0.35 27.90
CLDN5 0.0000257 5015 GTEx DepMap Descartes 0.16 24.46
CDH5 0.0000173 5621 GTEx DepMap Descartes 0.14 13.07
CRHBP 0.0000162 5720 GTEx DepMap Descartes 0.03 7.90
ROBO4 0.0000090 6392 GTEx DepMap Descartes 0.08 7.91
ECSCR -0.0000005 8475 GTEx DepMap Descartes 0.00 0.18
FCGR2B -0.0000071 10374 GTEx DepMap Descartes 0.02 2.39
F8 -0.0000072 10384 GTEx DepMap Descartes 0.15 7.41
TIE1 -0.0000124 11413 GTEx DepMap Descartes 0.10 10.05
FLT4 -0.0000230 12890 GTEx DepMap Descartes 0.05 3.47
DNASE1L3 -0.0000330 13851 GTEx DepMap Descartes 0.07 13.52
CYP26B1 -0.0000398 14402 GTEx DepMap Descartes 0.04 3.95
BTNL9 -0.0000481 15048 GTEx DepMap Descartes 0.08 8.46
IRX3 -0.0000490 15115 GTEx DepMap Descartes 0.01 1.69


Descartes stromal markers
Top 50 marker genes of stromal cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/stromal/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.24e-19
Mean rank of genes in gene set: 2670.84
Median rank of genes in gene set: 150
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
COL3A1 0.0091022 1 GTEx DepMap Descartes 22.70 2636.24
COL1A2 0.0090765 2 GTEx DepMap Descartes 25.13 2704.87
COL1A1 0.0089022 3 GTEx DepMap Descartes 26.11 2919.87
LUM 0.0079013 5 GTEx DepMap Descartes 3.34 760.33
MGP 0.0076330 6 GTEx DepMap Descartes 9.18 3183.28
SFRP2 0.0059625 9 GTEx DepMap Descartes 1.48 455.13
DCN 0.0057837 10 GTEx DepMap Descartes 3.84 333.99
POSTN 0.0053938 12 GTEx DepMap Descartes 5.02 937.88
CCDC80 0.0051759 15 GTEx DepMap Descartes 2.32 114.52
LOX 0.0045611 21 GTEx DepMap Descartes 0.39 45.05
ISLR 0.0042190 26 GTEx DepMap Descartes 0.48 125.10
COL6A3 0.0038533 30 GTEx DepMap Descartes 6.38 385.35
FNDC1 0.0037311 31 GTEx DepMap Descartes 0.84 81.35
CDH11 0.0027664 50 GTEx DepMap Descartes 4.77 393.24
PDGFRA 0.0022798 69 GTEx DepMap Descartes 0.42 37.37
PRICKLE1 0.0021912 72 GTEx DepMap Descartes 4.81 471.50
IGFBP3 0.0021357 74 GTEx DepMap Descartes 0.61 120.08
MXRA5 0.0021195 77 GTEx DepMap Descartes 0.42 26.05
PRRX1 0.0017384 92 GTEx DepMap Descartes 2.56 370.34
CD248 0.0015997 105 GTEx DepMap Descartes 0.18 39.76
C7 0.0014879 117 GTEx DepMap Descartes 6.19 686.04
PCOLCE 0.0014044 126 GTEx DepMap Descartes 0.73 282.32
ITGA11 0.0013903 128 GTEx DepMap Descartes 1.65 103.67
EDNRA 0.0013743 131 GTEx DepMap Descartes 1.35 192.89
OGN 0.0012791 150 GTEx DepMap Descartes 0.39 64.58
COL12A1 0.0011773 170 GTEx DepMap Descartes 3.33 163.95
DKK2 0.0010957 188 GTEx DepMap Descartes 0.49 67.30
ADAMTS2 0.0010937 190 GTEx DepMap Descartes 1.91 178.69
PCDH18 0.0009684 219 GTEx DepMap Descartes 0.21 21.68
GLI2 0.0009255 239 GTEx DepMap Descartes 1.34 122.23


Descartes sympathoblasts markers
Top 50 marker genes of sympathoblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/sympathoblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 17640.37
Median rank of genes in gene set: 18612
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
SCG2 0.0000848 2672 GTEx DepMap Descartes 4.50 990.71
TMEM130 0.0000005 7615 GTEx DepMap Descartes 0.36 41.04
PNMT -0.0000178 12257 GTEx DepMap Descartes 0.01 6.92
HTATSF1 -0.0000390 14342 GTEx DepMap Descartes 0.24 43.68
ST18 -0.0000426 14628 GTEx DepMap Descartes 0.09 5.25
SORCS3 -0.0000463 14892 GTEx DepMap Descartes 0.25 15.63
SLC24A2 -0.0000495 15159 GTEx DepMap Descartes 0.15 4.54
GRID2 -0.0000619 15938 GTEx DepMap Descartes 0.55 31.70
SLC35F3 -0.0000654 16113 GTEx DepMap Descartes 0.43 33.68
DGKK -0.0000792 16805 GTEx DepMap Descartes 0.05 2.45
PCSK1N -0.0000806 16858 GTEx DepMap Descartes 1.73 853.06
C1QL1 -0.0000874 17149 GTEx DepMap Descartes 0.07 22.20
CDH12 -0.0000940 17385 GTEx DepMap Descartes 0.89 71.55
SLC18A1 -0.0000994 17588 GTEx DepMap Descartes 0.05 6.50
PENK -0.0001113 17992 GTEx DepMap Descartes 0.03 15.83
ARC -0.0001149 18101 GTEx DepMap Descartes 0.04 6.64
PCSK2 -0.0001229 18322 GTEx DepMap Descartes 0.27 19.52
INSM1 -0.0001233 18328 GTEx DepMap Descartes 0.04 7.45
CNTN3 -0.0001245 18360 GTEx DepMap Descartes 0.17 12.19
CDH18 -0.0001254 18376 GTEx DepMap Descartes 0.43 27.21
CNTNAP5 -0.0001261 18383 GTEx DepMap Descartes 0.39 18.50
EML6 -0.0001366 18612 GTEx DepMap Descartes 0.71 20.65
GRM7 -0.0001416 18722 GTEx DepMap Descartes 0.66 67.33
KSR2 -0.0001417 18728 GTEx DepMap Descartes 0.31 5.58
NTNG1 -0.0001488 18845 GTEx DepMap Descartes 0.79 59.64
FGF14 -0.0001500 18867 GTEx DepMap Descartes 4.20 133.45
CHGA -0.0001568 18997 GTEx DepMap Descartes 0.43 117.58
PACRG -0.0001577 19013 GTEx DepMap Descartes 0.49 111.62
SPOCK3 -0.0001612 19067 GTEx DepMap Descartes 0.21 27.90
MGAT4C -0.0001696 19199 GTEx DepMap Descartes 1.33 31.08


Descartes erythroblasts markers
Top 50 marker genes of erythroblasts cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/erythroblasts/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13446.35
Median rank of genes in gene set: 13591
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
MICAL2 0.0007909 280 GTEx DepMap Descartes 2.39 212.30
GYPC 0.0002221 1137 GTEx DepMap Descartes 0.23 70.09
SELENBP1 0.0000502 3784 GTEx DepMap Descartes 0.04 9.04
HBB 0.0000252 5050 GTEx DepMap Descartes 0.21 188.35
CPOX 0.0000154 5765 GTEx DepMap Descartes 0.04 7.39
GYPE 0.0000071 6583 GTEx DepMap Descartes 0.05 13.04
CAT 0.0000030 7120 GTEx DepMap Descartes 0.29 59.81
HBG1 0.0000022 7262 GTEx DepMap Descartes 0.00 0.07
HBG2 0.0000000 8122 GTEx DepMap Descartes 0.00 0.00
GYPB -0.0000025 9147 GTEx DepMap Descartes 0.01 6.45
GYPA -0.0000051 9869 GTEx DepMap Descartes 0.00 0.61
RHCE -0.0000079 10558 GTEx DepMap Descartes 0.04 10.01
HBZ -0.0000091 10813 GTEx DepMap Descartes 0.00 3.33
HEMGN -0.0000113 11234 GTEx DepMap Descartes 0.00 0.68
SPTA1 -0.0000143 11729 GTEx DepMap Descartes 0.00 0.27
HBA2 -0.0000151 11843 GTEx DepMap Descartes 0.06 58.20
HBA1 -0.0000180 12280 GTEx DepMap Descartes 0.02 20.20
AHSP -0.0000183 12321 GTEx DepMap Descartes 0.00 0.26
EPB42 -0.0000204 12581 GTEx DepMap Descartes 0.00 0.21
ALAS2 -0.0000248 13077 GTEx DepMap Descartes 0.00 0.67
HBM -0.0000264 13229 GTEx DepMap Descartes 0.00 1.04
SLC25A37 -0.0000267 13257 GTEx DepMap Descartes 0.61 58.05
ABCB10 -0.0000288 13459 GTEx DepMap Descartes 0.29 37.36
FECH -0.0000317 13723 GTEx DepMap Descartes 0.14 8.42
SLC4A1 -0.0000328 13836 GTEx DepMap Descartes 0.00 0.40
SLC25A21 -0.0000360 14104 GTEx DepMap Descartes 0.11 13.75
RHAG -0.0000366 14156 GTEx DepMap Descartes 0.00 0.71
CR1L -0.0000423 14600 GTEx DepMap Descartes 0.03 7.39
BLVRB -0.0000468 14927 GTEx DepMap Descartes 0.22 81.64
TMCC2 -0.0000592 15789 GTEx DepMap Descartes 0.07 7.88


Descartes myeloid markers
Top 50 marker genes of myeloid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/myeloid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.56e-01
Mean rank of genes in gene set: 9437.8
Median rank of genes in gene set: 6201
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
CST3 0.0014681 121 GTEx DepMap Descartes 1.78 298.75
CTSC 0.0006952 333 GTEx DepMap Descartes 0.81 71.29
TGFBI 0.0005205 457 GTEx DepMap Descartes 0.77 90.61
CTSB 0.0003577 698 GTEx DepMap Descartes 1.17 153.26
ABCA1 0.0002173 1167 GTEx DepMap Descartes 1.64 82.91
SPP1 0.0001911 1322 GTEx DepMap Descartes 1.55 467.28
FGL2 0.0001833 1373 GTEx DepMap Descartes 0.15 19.74
HLA-DPA1 0.0001796 1408 GTEx DepMap Descartes 0.36 38.59
ITPR2 0.0001410 1757 GTEx DepMap Descartes 2.93 115.88
HLA-DRA 0.0001335 1818 GTEx DepMap Descartes 0.59 238.05
LGMN 0.0001239 1948 GTEx DepMap Descartes 0.58 131.31
CD14 0.0001238 1951 GTEx DepMap Descartes 0.16 53.57
C1QB 0.0001131 2113 GTEx DepMap Descartes 0.19 101.72
RNASE1 0.0001076 2209 GTEx DepMap Descartes 0.14 69.16
IFNGR1 0.0000995 2353 GTEx DepMap Descartes 0.49 99.09
C1QA 0.0000969 2401 GTEx DepMap Descartes 0.20 107.30
C1QC 0.0000889 2568 GTEx DepMap Descartes 0.13 58.50
CTSS 0.0000775 2862 GTEx DepMap Descartes 0.35 42.04
HLA-DRB1 0.0000668 3180 GTEx DepMap Descartes 0.16 61.99
CD74 0.0000590 3445 GTEx DepMap Descartes 1.09 173.68
MS4A7 0.0000309 4722 GTEx DepMap Descartes 0.02 3.84
MPEG1 0.0000264 4978 GTEx DepMap Descartes 0.06 7.38
CYBB 0.0000185 5522 GTEx DepMap Descartes 0.01 1.32
CTSD 0.0000150 5790 GTEx DepMap Descartes 0.00 0.02
VSIG4 0.0000107 6201 GTEx DepMap Descartes 0.03 5.38
MS4A6A -0.0000071 10367 GTEx DepMap Descartes 0.19 37.37
CPVL -0.0000129 11516 GTEx DepMap Descartes 0.30 61.46
MS4A4A -0.0000276 13352 GTEx DepMap Descartes 0.14 35.70
CSF1R -0.0000425 14619 GTEx DepMap Descartes 0.17 20.69
AXL -0.0000510 15256 GTEx DepMap Descartes 0.90 103.70


Descartes Schwann markers
Top 50 marker genes of Schwann cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/schwann/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 9.99e-01
Mean rank of genes in gene set: 12936.33
Median rank of genes in gene set: 19002
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
VCAN 0.0047246 19 GTEx DepMap Descartes 7.91 358.23
COL5A2 0.0026329 57 GTEx DepMap Descartes 5.51 475.88
VIM 0.0017469 91 GTEx DepMap Descartes 4.66 950.51
SFRP1 0.0015817 107 GTEx DepMap Descartes 0.83 100.21
KCTD12 0.0010582 205 GTEx DepMap Descartes 0.55 44.21
MARCKS 0.0008674 251 GTEx DepMap Descartes 1.98 253.14
COL18A1 0.0006522 356 GTEx DepMap Descartes 3.12 277.87
PMP22 0.0006177 380 GTEx DepMap Descartes 1.33 364.10
LAMA4 0.0005382 446 GTEx DepMap Descartes 2.88 215.20
LAMB1 0.0004795 494 GTEx DepMap Descartes 2.70 263.55
ERBB4 0.0002056 1231 GTEx DepMap Descartes 2.37 67.46
LAMC1 0.0001981 1280 GTEx DepMap Descartes 1.88 127.15
ADAMTS5 0.0001469 1699 GTEx DepMap Descartes 0.21 10.62
PLP1 0.0001191 2024 GTEx DepMap Descartes 0.19 25.92
PTN 0.0000533 3644 GTEx DepMap Descartes 0.38 121.95
MDGA2 0.0000338 4573 GTEx DepMap Descartes 0.93 57.55
FIGN -0.0000116 11276 GTEx DepMap Descartes 1.98 113.02
MPZ -0.0000263 13216 GTEx DepMap Descartes 0.12 25.66
NRXN3 -0.0000311 13662 GTEx DepMap Descartes 5.23 274.17
TRPM3 -0.0000476 14988 GTEx DepMap Descartes 0.72 19.20
SOX10 -0.0000508 15250 GTEx DepMap Descartes 0.09 13.02
GAS7 -0.0000572 15677 GTEx DepMap Descartes 2.09 142.46
ERBB3 -0.0000886 17182 GTEx DepMap Descartes 0.05 3.82
PTPRZ1 -0.0001230 18324 GTEx DepMap Descartes 0.41 21.52
GFRA3 -0.0001570 19002 GTEx DepMap Descartes 0.10 24.14
HMGA2 -0.0001637 19106 GTEx DepMap Descartes 0.17 11.86
PPP2R2B -0.0001692 19195 GTEx DepMap Descartes 2.72 79.33
LRRTM4 -0.0001767 19282 GTEx DepMap Descartes 1.99 194.02
XKR4 -0.0001879 19423 GTEx DepMap Descartes 1.52 28.88
ZNF536 -0.0002038 19597 GTEx DepMap Descartes 0.91 63.49


Descartes Megakaryocytes markers
Top 50 marker genes of Megakaryocytes cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/megakaryocytes/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.83e-01
Mean rank of genes in gene set: 10696.24
Median rank of genes in gene set: 10841
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
GSN 0.0016426 101 GTEx DepMap Descartes 2.33 203.34
FLNA 0.0011797 169 GTEx DepMap Descartes 1.21 78.73
THBS1 0.0008961 248 GTEx DepMap Descartes 4.47 326.27
TMSB4X 0.0008092 269 GTEx DepMap Descartes 5.47 1804.71
ACTB 0.0007354 305 GTEx DepMap Descartes 5.18 1307.56
MYLK 0.0003943 617 GTEx DepMap Descartes 1.14 64.38
TLN1 0.0003858 638 GTEx DepMap Descartes 0.69 41.83
TGFB1 0.0002654 942 GTEx DepMap Descartes 0.65 128.24
MYH9 0.0002572 973 GTEx DepMap Descartes 2.73 196.75
CD9 0.0002501 1005 GTEx DepMap Descartes 1.04 270.21
TPM4 0.0001942 1309 GTEx DepMap Descartes 2.45 270.35
SLC24A3 0.0001855 1354 GTEx DepMap Descartes 1.90 282.50
DOK6 0.0001270 1901 GTEx DepMap Descartes 1.57 93.67
STOM 0.0001252 1931 GTEx DepMap Descartes 0.68 104.05
PPBP 0.0000256 5026 GTEx DepMap Descartes 0.00 0.26
ZYX 0.0000229 5190 GTEx DepMap Descartes 0.27 62.23
PF4 0.0000185 5521 GTEx DepMap Descartes 0.00 0.46
FERMT3 0.0000165 5681 GTEx DepMap Descartes 0.08 15.49
GP1BA 0.0000112 6144 GTEx DepMap Descartes 0.02 4.39
TUBB1 0.0000075 6541 GTEx DepMap Descartes 0.01 1.58
SPN 0.0000020 7306 GTEx DepMap Descartes 0.00 0.00
GP9 -0.0000038 9516 GTEx DepMap Descartes 0.00 0.00
ITGB3 -0.0000041 9622 GTEx DepMap Descartes 0.00 0.08
CD84 -0.0000067 10266 GTEx DepMap Descartes 0.09 4.98
PSTPIP2 -0.0000092 10841 GTEx DepMap Descartes 0.14 24.60
PLEK -0.0000144 11745 GTEx DepMap Descartes 0.08 12.02
P2RX1 -0.0000441 14729 GTEx DepMap Descartes 0.02 3.40
LTBP1 -0.0000506 15237 GTEx DepMap Descartes 1.52 125.03
BIN2 -0.0000597 15820 GTEx DepMap Descartes 0.05 9.45
ITGA2B -0.0000601 15838 GTEx DepMap Descartes 0.05 5.99


Descartes Lyphoid markers
Top 50 marker genes of Lyphoid cells in the Decartes fetal adrenal single cell map (https://atlas.brotmanbaty.org/bbi/human-gene-expression-during-development/cell/lymphoid/in/adrenal)
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.00e+00
Mean rank of genes in gene set: 13584.34
Median rank of genes in gene set: 18536
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
B2M 0.0006123 383 GTEx DepMap Descartes 6.32 1422.81
HLA-C 0.0004832 490 GTEx DepMap Descartes 0.57 156.96
HLA-A 0.0004661 508 GTEx DepMap Descartes 1.11 106.21
HLA-B 0.0004113 592 GTEx DepMap Descartes 0.77 246.04
TMSB10 0.0003942 618 GTEx DepMap Descartes 5.35 6704.91
FOXP1 0.0003344 742 GTEx DepMap Descartes 0.45 26.38
IFI16 0.0003039 808 GTEx DepMap Descartes 1.14 148.57
SAMD3 0.0001823 1380 GTEx DepMap Descartes 0.55 81.10
LEF1 0.0001819 1384 GTEx DepMap Descartes 0.98 136.00
SP100 0.0000975 2392 GTEx DepMap Descartes 1.41 144.10
MCTP2 0.0000914 2514 GTEx DepMap Descartes 0.38 23.15
CCL5 0.0000274 4914 GTEx DepMap Descartes 0.05 20.68
MSN 0.0000221 5254 GTEx DepMap Descartes 0.94 116.32
ARHGDIB 0.0000096 6331 GTEx DepMap Descartes 0.17 80.30
NKG7 0.0000070 6599 GTEx DepMap Descartes 0.01 9.71
PLEKHA2 -0.0000128 11506 GTEx DepMap Descartes 0.96 93.78
WIPF1 -0.0000279 13382 GTEx DepMap Descartes 1.26 136.61
LCP1 -0.0000637 16033 GTEx DepMap Descartes 0.14 16.60
GNG2 -0.0000822 16922 GTEx DepMap Descartes 1.09 137.81
PTPRC -0.0000970 17491 GTEx DepMap Descartes 0.47 43.07
IKZF1 -0.0001037 17755 GTEx DepMap Descartes 0.20 15.81
ITPKB -0.0001097 17944 GTEx DepMap Descartes 0.49 38.50
SKAP1 -0.0001111 17987 GTEx DepMap Descartes 0.24 64.87
PRKCH -0.0001326 18536 GTEx DepMap Descartes 0.93 121.22
SORL1 -0.0001344 18564 GTEx DepMap Descartes 0.36 15.33
CCND3 -0.0001634 19099 GTEx DepMap Descartes 0.98 227.93
SCML4 -0.0001648 19120 GTEx DepMap Descartes 0.18 14.82
FYN -0.0001944 19505 GTEx DepMap Descartes 2.20 286.60
STK39 -0.0001980 19538 GTEx DepMap Descartes 1.38 196.67
DOCK10 -0.0001989 19549 GTEx DepMap Descartes 2.10 151.13


Embryonic Pausing Signatures Up
Embryonic pausing signature upregulated genes from Supplementary Table 6 of Rehman et al. Cell 2021. These genes are upregulated in paused ESCs and diapaused embryos.
Wilcoxon ranksum test P-value for gene set overrepresentation: 6.88e-04
Mean rank of genes in gene set: 5225.43
Median rank of genes in gene set: 3924.5
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
APOE 0.0011160 185 GTEx DepMap Descartes 2.96 1405.34
HEXB 0.0005071 466 GTEx DepMap Descartes 0.43 110.08
SPRY1 0.0004274 563 GTEx DepMap Descartes 0.71 142.98
HEXA 0.0003277 756 GTEx DepMap Descartes 0.07 5.09
CTSL 0.0002877 859 GTEx DepMap Descartes 0.60 NA
DPP7 0.0002496 1008 GTEx DepMap Descartes 0.35 119.03
PDCD4 0.0000571 3508 GTEx DepMap Descartes 0.77 105.31
CCNG2 0.0000381 4341 GTEx DepMap Descartes 0.27 26.38
YPEL2 0.0000375 4371 GTEx DepMap Descartes 0.97 92.75
ALDH6A1 0.0000307 4737 GTEx DepMap Descartes 0.11 10.46
LY6G6E 0.0000000 8215 GTEx DepMap Descartes 0.00 0.00
RENBP -0.0000044 9702 GTEx DepMap Descartes 0.07 27.44
ACSS1 -0.0000593 15796 GTEx DepMap Descartes 0.15 16.95
AUH -0.0001380 18649 GTEx DepMap Descartes 1.19 347.81


Embryonic Pausing Signatures Down
Embryonic pausing signature downregulated genes from Supplementary Table 6 of Rehman et al. Cell 2021. These genes are downregulated in paused ESCs and diapaused embryos.
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.47e-06
Mean rank of genes in gene set: 7589.32
Median rank of genes in gene set: 5494
Rank on gene expression program of top 30 genes in gene set:

Genes Weight Rank GTEx DepMap Descartes Mean.Counts Mean.TPM
ID3 0.0025160 62 GTEx DepMap Descartes 1.08 622.50
ARPC1B 0.0007914 279 GTEx DepMap Descartes 0.25 68.91
P4HB 0.0006255 372 GTEx DepMap Descartes 0.96 207.05
TMEM109 0.0003879 633 GTEx DepMap Descartes 0.14 33.04
DAD1 0.0003162 777 GTEx DepMap Descartes 0.48 382.71
RPS27L 0.0002949 835 GTEx DepMap Descartes 0.70 61.76
HDLBP 0.0002928 842 GTEx DepMap Descartes 1.33 110.49
POLR2L 0.0002681 932 GTEx DepMap Descartes 0.38 223.08
SLC25A5 0.0002581 968 GTEx DepMap Descartes 0.31 128.23
S100A6 0.0002257 1118 GTEx DepMap Descartes 2.94 1934.59
NDUFC1 0.0002251 1121 GTEx DepMap Descartes 0.40 163.77
ANKRD37 0.0002240 1132 GTEx DepMap Descartes 0.09 31.06
PRADC1 0.0002212 1145 GTEx DepMap Descartes 0.08 35.65
RPL41 0.0002082 1221 GTEx DepMap Descartes 2.52 1984.71
SEC13 0.0001869 1343 GTEx DepMap Descartes 0.47 106.80
PGAM1 0.0001716 1464 GTEx DepMap Descartes 0.35 103.17
TMEM258 0.0001675 1508 GTEx DepMap Descartes 0.54 NA
RPS19BP1 0.0001619 1550 GTEx DepMap Descartes 0.28 53.23
UQCR10 0.0001328 1826 GTEx DepMap Descartes 0.62 372.21
ATOX1 0.0001259 1918 GTEx DepMap Descartes 0.50 61.89
HILPDA 0.0001231 1958 GTEx DepMap Descartes 0.09 37.54
MRPL18 0.0001215 1983 GTEx DepMap Descartes 0.22 106.93
PDCD5 0.0001166 2056 GTEx DepMap Descartes 0.43 131.11
CAPG 0.0001017 2319 GTEx DepMap Descartes 0.06 26.30
NAA10 0.0001003 2344 GTEx DepMap Descartes 0.06 19.43
GNG10 0.0000949 2447 GTEx DepMap Descartes 0.01 3.11
PSMB10 0.0000922 2499 GTEx DepMap Descartes 0.03 18.37
UQCRQ 0.0000863 2631 GTEx DepMap Descartes 0.50 176.56
UBE2V1 0.0000842 2685 GTEx DepMap Descartes 0.02 4.54
PRDX2 0.0000827 2727 GTEx DepMap Descartes 0.19 63.65


Below shows the ranks on this GEP for immune marker gene lists curated by CellTypist (https://www.celltypist.org/encyclopedia).
   High ranks indicate this gene is a driver of this GEP.
  These curated gene list are ranked by P-value (on this GEP) of their constituent genes.
  The Mean Count column shows the mean read count in cells scoring highly (H > 50) on this gene expression program.


Fibroblasts: Fibroblasts (model markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.98e-05
Mean rank of genes in gene set: 2572.2
Rank on gene expression program of genes in gene set:
Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
PDGFRA 0.0022798 69 GTEx DepMap Descartes 0.42 37.37
MXRA5 0.0021195 77 GTEx DepMap Descartes 0.42 26.05
PRRX1 0.0017384 92 GTEx DepMap Descartes 2.56 370.34
SFRP1 0.0015817 107 GTEx DepMap Descartes 0.83 100.21
OLFML1 0.0007686 289 GTEx DepMap Descartes 0.10 21.14
SMOC2 0.0004403 546 GTEx DepMap Descartes 1.35 253.06
NTRK2 0.0003362 741 GTEx DepMap Descartes 1.03 62.90
ANGPTL1 0.0002124 1196 GTEx DepMap Descartes 0.22 32.30
F10 0.0001124 2119 GTEx DepMap Descartes 0.05 18.48
EBF2 -0.0004346 20486 GTEx DepMap Descartes 1.59 173.65


Fibroblasts: Fibroblasts (curated markers)
the most common cells of connective tissues which synthesize the extracellular matrix and collagen to maintain tissue homeostasis:
Wilcoxon ranksum test P-value for gene set overrepresentation: 1.36e-03
Mean rank of genes in gene set: 5
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
COL1A2 0.0090765 2 GTEx DepMap Descartes 25.13 2704.87
COL1A1 0.0089022 3 GTEx DepMap Descartes 26.11 2919.87
DCN 0.0057837 10 GTEx DepMap Descartes 3.84 333.99


Monocytes: Monocytes (model markers)
myeloid mononuclear recirculating leukocytes that are capable of differentiating into macrophages and myeloid lineage dendritic cells:
Wilcoxon ranksum test P-value for gene set overrepresentation: 3.87e-03
Mean rank of genes in gene set: 5019
Rank on gene expression program of genes in gene set:

Genes Weight Rank GTEx DepMap Decartes Mean.Counts Mean.TPM
FTL 0.0005620 429 GTEx DepMap Descartes 5.19 3123.53
HLA-DPB1 0.0001573 1602 GTEx DepMap Descartes 0.35 46.67
TYROBP 0.0000745 2954 GTEx DepMap Descartes 0.12 94.69
RPS17 0.0000450 3998 GTEx DepMap Descartes 0.15 41.12
LYZ 0.0000346 4531 GTEx DepMap Descartes 0.19 64.15
SAT1 0.0000282 4873 GTEx DepMap Descartes 1.87 748.22
TRAC 0.0000033 7069 GTEx DepMap Descartes 0.02 12.51
IGLC2 0.0000030 7109 GTEx DepMap Descartes 0.24 351.34
IGKC -0.0000205 12606 GTEx DepMap Descartes 0.83 1040.95